Search

Magnetic fields can be reorganized by plasma flows and lead to effects such as magnetic reconnection. Here the authors explore the evolution of magnetized-plasma bubbles in a semi-collisional regime and the role of pressure anisotropy in influencing the flow of the laser-produced plasma.

This review summarizes the available literature on the knowledge of reproduction in white whales or belugas (Delphinapterus leucas). We discuss reproductive anatomy, physiology, endocrinology, and behavior prior to conception. Following a description of these basic reproductive parameters for each sex, the review describes the mating system of belugas as it is currently understood and summarizes the ontogeny of reproductive behavior and its relationship with hormones. Finally, we highlight gaps that currently exist in our functional understanding of reproductive behavior in belugas. Future research emphasizes the need to understand mate choice in belugas and how it manifests across the lifespan and potentially settings. Specifically, does the quality of belugas’ display behaviors influence reproductive success? Managing wild populations of belugas and caring for belugas in human care both benefit from the knowledge that can be gained from the research topics discussed in this review.

Abstract Objective To identify and assess the globally available valid, reliable and acceptable tools for assessing health research partnership outcomes and impacts. Methods We searched Ovid MEDLINE, Embase, CINAHL Plus and PsycINFO from origin to 2 June 2021, without limits, using an a priori strategy and registered protocol. We screened citations independently and in duplicate, resolving discrepancies by consensus and retaining studies involving health research partnerships, the development, use and/or assessment of tools to evaluate partnership outcomes and impacts, and reporting empirical psychometric evidence. Study, tool, psychometric and pragmatic characteristics were abstracted using a hybrid approach, then synthesized using descriptive statistics and thematic analysis. Study quality was assessed using the quality of survey studies in psychology (Q-SSP) checklist. Results From 56 123 total citations, we screened 36 027 citations, assessed 2784 full-text papers, abstracted data from 48 studies and one companion report, and identified 58 tools. Most tools comprised surveys, questionnaires and scales. Studies used cross-sectional or mixed-method/embedded survey designs and employed quantitative and mixed methods. Both studies and tools were conceptually well grounded, focusing mainly on outcomes, then process, and less frequently on impact measurement. Multiple forms of empirical validity and reliability evidence was present for most tools; however, psychometric characteristics were inconsistently assessed and reported. We identified a subset of studies (22) and accompanying tools distinguished by their empirical psychometric, pragmatic and study quality characteristics. While our review demonstrated psychometric and pragmatic improvements over previous reviews, challenges related to health research partnership assessment and the nascency of partnership science persist. Conclusion This systematic review identified multiple tools demonstrating empirical psychometric evidence, pragmatic strength and moderate study quality. Increased attention to psychometric and pragmatic requirements in tool development, testing and reporting is key to advancing health research partnership assessment and partnership science. PROSPERO CRD42021137932

Abstract Background Although a number of imprinted genes are known to be highly expressed in the brain, and in certain brain regions in particular, whether they are truly over-represented in the brain has never been formally tested. Using thirteen single-cell RNA sequencing datasets we systematically investigated imprinted gene over-representation at the organ, brain region, and cell-specific levels. Results We established that imprinted genes are indeed over-represented in the adult brain, and in neurons particularly compared to other brain cell-types. We then examined brain-wide datasets to test enrichment within distinct brain regions and neuron subpopulations and demonstrated over-representation of imprinted genes in the hypothalamus, ventral midbrain, pons and medulla. Finally, using datasets focusing on these regions of enrichment, we identified hypothalamic neuroendocrine populations and the monoaminergic hindbrain neurons as specific hotspots of imprinted gene expression. Conclusions These analyses provide the first robust assessment of the neural systems on which imprinted genes converge. Moreover, the unbiased approach, with each analysis informed by the findings of the previous level, permits highly informed inferences about the functions on which imprinted gene expression converges. Our findings indicate the neuronal regulation of motivated behaviours such as feeding and sleep, alongside the regulation of pituitary function, as functional hotspots for imprinting. This adds statistical rigour to prior assumptions and provides testable predictions for novel neural and behavioural phenotypes associated with specific genes and imprinted gene networks. In turn, this work sheds further light on the potential evolutionary drivers of genomic imprinting in the brain.

Abstract Strong evidence demonstrates a significant association between cerebral amyloid angiopathy (CAA) and Alzheimer’s disease (AD). For this reason, interest in understanding the underlying vascular pathologies that contribute to AD remain. CAA research has primarily focused on arterioles and capillaries, overlooking the draining venules. Therefore, this study sought to examine venular amyloid pathology and its relationship to arteriolar amyloidosis throughout AD progression in the TgF344-AD rat model. Antibodies targeting the amyloid-beta peptide (Aβ) sequence suggest morphological differences between arteriolar and venular amyloid. Mass spectrometric analyses of isolated cortical parenchymal plaques, arteriolar and venular amyloid demonstrated presence of Aβ in all three samples, as well as proteins known to be associated with AD. Histopathological analysis indicates a significant age effect for both arteriolar and venular amyloid accumulation, with accumulation initiated in the somatosensory cortex followed by the motor and cingulate cortex. Lastly, significant arteriolar amyloid accumulates relative to venular amyloid deposition in AD progression. Overall, understanding venular and arteriolar amyloid pathology provides insight into the complex connection between CAA and AD.

We present an event observed by Parker Solar Probe (PSP) at ∼0.2 au on 2022 March 2 in which imaging and in situ measurements coincide. During this event, PSP passed through structures on the flank of a streamer blowout coronal mass ejection (CME) including an isolated flux tube in front of the CME, a turbulent sheath, and the CME itself. Imaging observations and in situ helicity and principal variance signatures consistently show the presence of flux ropes internal to the CME. In both the sheath and the CME interval, the distributions are more isotropic, the spectra are softer, and the abundance ratios of Fe/O and He/H are lower than those in the isolated flux tube, and yet elevated relative to typical plasma and solar energetic particle abundances. These signatures in the sheath and the CME indicate that both flare populations and those from the plasma are accelerated to form the observed energetic particle enhancements. In contrast, the isolated flux tube shows large streaming, hard spectra, and large Fe/O and He/H ratios, indicating flare sources. Energetic particle fluxes are most enhanced within the CME interval from suprathermal through energetic particle energies (∼keV to >10 MeV), indicating particle acceleration, as well as confinement local to the closed magnetic structure. The flux-rope morphology of the CME helps to enable local modulation and trapping of energetic particles, in particular along helicity channels and other plasma boundaries. Thus, the CME acts to build up energetic particle populations, allowing them to be fed into subsequent higher-energy particle acceleration throughout the inner heliosphere where a compression or shock forms on the CME front.

High-energy neutral solar radiation in the form of γ -rays and neutrons is produced as secondary products in solar flares. The characteristics of this emission can provide key information regarding the energization of charged particles, particularly when primary particles remain trapped in the corona. The Integrated Science Investigation of the Sun (IS⊙IS) suite on Parker Solar Probe is composed of instruments primarily intended to measure energetic charged particles. However, the High Energy Telescope (HET) in IS⊙IS was also designed with a supplementary neutral mode intended to measure γ -rays and neutrons. HET observed its first clear solar γ -ray event in connection with a hard X-ray flare, the eruption of a coronal mass ejection, and a solar energetic particle event on 2022 September 5. The X-ray spectral shape was observed to harden over the course of the event, culminating with the observation of γ -rays by HET. A coincident enhancement in the lower-energy Energetic Particle Instrument (EPI-Lo) was also observed, likely produced by incident solar γ -rays despite the EPI-Lo instrument not having any special neutral measurement capabilities. We use Monte Carlo modeling to reconstruct the incident γ -ray spectrum based on the measured spectrum to demonstrate that the combination of IS⊙IS instruments can measure hard X-rays and γ -rays from ∼60 keV–7 MeV. Despite the fact that this is a supplemental science goal of the mission, the capability of the IS⊙IS instruments to measure γ -rays is important for the study of this population due to the very limited instruments currently observing the Sun in γ -rays.

On 2022 September 5, Parker Solar Probe (Parker) observed a large solar energetic particle (SEP) event at the unprecedented distance of only 15 R _S from the Sun. The observations from the Integrated Science Investigation of the Sun (IS⊙IS) obtained over the course of this event are remarkably rich, and an overview is presented here. IS⊙IS is capable of measuring ions from 20 keV to over 100 MeV nuc ^−1 and electrons from 30 keV to 6 MeV; here, we primarily focus on the proton and helium measurements above 80 keV. Among the surprising results are evidence of inverse velocity dispersion at energies above 1 MeV during the onset of the event, a sharp decrease in the energetic particle intensities at all energies at the interplanetary shock crossing, and repeated short durations of highly anisotropic sunward flow. Many changes in the SEP intensities, anisotropy, and spectral steepness are coincident with solar wind structure boundaries identified using the Parker solar wind magnetic field and plasma data. However, there are significant changes that are not correlated with any clearly visible solar wind variation. The observations presented here serve as an introduction to a complex event with numerous opportunities for future, more in-depth studies.

Parker Solar Probe (PSP) observations of a small dispersive event on 2022 February 27 and 28 indicate scatter-free propagation as the dominant transport mechanism between the low corona and greater than 35 solar radii. The event occurred during unique orbital conditions that prevailed along specific flux tubes that PSP encountered repeatedly between 25 and 35 R _s during outbound orbit 11. This segment of the PSP orbit exhibits almost stationary angular motion relative to the rotating solar surface, such that in the rotating frame, PSP’s motion is essentially radial. The time dispersion often observed in impulsive solar energetic particle (SEP) events continues in this case down to velocities including the core solar-wind ion velocities. Especially at the onset of this event, the ^3 He content is much larger than the usual SEP abundances seen in the energy range from ∼100 keV to several MeV for helium. Later in the event, iron is enhanced. The compositional signatures suggest this to be an example of an acceleration mechanism for generating the seed energetic particles required by shock (or compression) acceleration models in SEP events to account for the enrichment of various species above solar abundances in such events. A preliminary search of similar orbital conditions over the PSP mission has not revealed additional such events, although favorable conditions (isolated impulsive acceleration and well-ordered magnetic field connection with minimal magnetic field fluctuation) that would be required are infrequently realized, given the small fraction of the PSP trajectory that meets these observation conditions.

The recently published Interstellar Probe (ISP) study report describes a pragmatic mission concept with a launch window that starts in 2036 and is expected to reach several hundreds of astronomical units past the heliopause within a time frame of ≥50 years (https://interstellarprobe.jhuapl.edu/Interstellar-Probe-MCR.pdf). Following the ISP report, this paper, that will also be accessible from the Bulletin of the AAS (BAAS) in the framework of the Decadal Survey for Solar and Space Physics (Heliophysics) 2024–2033 (Dialynas et al., A future Interstellar Probe on the dynamic heliosphere and its interaction with the very local interstellar medium: In-situ particle and fields measurements and remotely sensed ENAs, 2022a), aims to highlight the importance of studying the physics of the interactions pertaining to the expanding solar wind that meets the plasma, gas and dust flows of the very local interstellar medium, forming the complex and vast region of our astrosphere. We focus on three fundamental open science questions that reveal the dynamical nature of the heliosphere A) Where are the heliosphere boundaries and how thick is the heliosheath B) Is there a “missing” pressure component towards exploring the dynamics of the global heliosheath and its interaction with the very local interstellar medium C) Why does the shape and size of the global heliosphere appear different in different Energetic Neutral Atom energies? We argue that these questions can only be addressed by exploiting a combination of in-situ charged particle, plasma waves and fields measurements with remotely sensed Energetic Neutral Atoms that can be measured simultaneously from the instruments of a future Interstellar Probe mission, along its trajectory from interplanetary space through the heliosheath and out to the very local interstellar medium.

Animal documentary films such as Blackfish, considered nonfiction accounts of reality, nonetheless use rhetorical devices to engage viewers and shape their emotional experience for maximum effect. Such devices can also influence attitudes and alter behavior. In animal documentaries, anthropomorphic impressions of the animals by audiences are key. Using general population samples in the US, three online experiments assessed the influence of background music and narrative setting on how viewers emotionally appraised the emotional state of a killer whale (Orcinus orca) and subsequently donated to causes affiliated with killer whales. While happy music led to perceptions of a happy whale, sad music led to perceptions of a sad whale. mediation analyses showed that these perceptions indirectly influence donation behavior, via beliefs about the killer whale's welfare and wellbeing. Analyses also indicated that the highest donation amounts towards killer whales were elicited from footage depicting a killer whale in the wild, with sad background music. These findings highlight the potential power that animal and nature documentaries have over viewers, which, when combined with human tendencies toward anthropomorphism, can have significant influence on conservation attitudes and behavior.

For dolphins, the strongest bond documented is typically that between a mother and her pre-weaned offspring, but outside of the maternal relationship, our knowledge of calf behavior is limited. We examined how 23 bottlenose dolphin (Tursiops truncatus) calves (11 females and 12 males from 9 matrilines) initiated pectoral fin contact (PFC) exchanges with their mothers and kin (n = 362) versus with non-kin (n = 950). Calves initiated PFC exchanges with preferred partners (primarily their mothers) over individuals who were simply available to them. For calves with mothers as their only kin available, there was a difference in how they shared PFC with non-kin adults versus non-kin young. A calf was twice as likely to initiate PFC with an adult (mother or adult non-kin) as with another young dolphin. Male and female calves were different in how they initiated PFC with kin and non-kin, which supports previous research that identified a sex difference in calf behavior. These results support the observation that kin and non-kin dolphins share PFC differently. It is also likely that kin (mothers and calves, siblings, etc.) use other forms of contact to share information and potentially develop their relationships. Understanding all types of tactile contact would facilitate a more detailed understanding of how touch might be used by dolphins when relationships are established and maintained.

Belugas (Delphinapterus leucas) in managed care have been reported to show seasonal variation in socio-sexual behaviour, hormone levels and respiration rates; however, little is known about the social interactions of wild belugas when they are not in summer, near-shore congregations. To better understand if belugas show seasonal variation in social interactions, this study recorded the behaviour of 10 belugas (five females, five males, ranging from birth to 10 years of age) housed in managed care. Social interactions typically peaked in the summer months but persisted at very low levels during the rest of the year. Seasonal variation was most dramatic for socio-sexual behaviour but was generally mirrored in pattern by agonistic and affiliative interactions. Subjects closer to maturity displayed more seasonal variation than younger subjects, and males displayed more seasonal variation compared to females. The peak in social interactions found in this study aligns rather closely with wild belugas’ summer, near-shore congregations, where belugas have increased opportunities for socializing. Although belugas in managed care do not experience a seasonal change in habitat, they do show seasonal changes in social behaviour, which are likely driven by seasonal fluctuations in hormone levels. It is therefore expected that wild beluga populations would show similar behavioural patterns if they were observed throughout the remainder of the year. This research has applications for belugas in managed care and may provide a framework for understanding the social behaviour of wild belugas.

Behavioural observations of captive beluga whales have complemented and extended much of what has been learnt about this species in the wild. Aquarium-based research has provided finer-scale specificity for many topics, including the seasonal breeding pattern that is characteristic of this species, as well as socio-sexual behaviour that appears to be an important part of the behavioural repertoire of this species. One example is a strong propensity for male–male social interactions that begin to develop at an early age. In addition, detailed behavioural milestones in calves have been documented in ways that extend that which have been collected from wild populations. These include swim positions with mother, separations/reunions with mother, and other social interactions, and play. Characteristics of beluga maternal care have also been studied more often in captive settings than in the wild, particularly with respect to details pertaining to nursing behaviour, individual differences in maternal style and allomaternal care. Other topics that have received scientific scrutiny in zoological settings include individual differences and behavioural laterality. Thus, a greater understanding of beluga behavioural biology has the potential to emerge as a consequence of synergy between research conducted in the two settings.

Adult bottlenose dolphins share pectoral fin contacts (PFC) to manage their social relationships but less is known about how mothers share PFC with their calves. Using a dataset collected over 16 years, we analyzed how 10 matrilines, including three second generation female dolphins in a maternal role, used PFC with their pre-weaned calves. Mothers had different rates of initiation with their calves forming a continuum from those initiating few contacts (15%) to those initiating more (44%). For mothers with all-aged calves, the lateral side was contacted the most to start interactions with mothers contacting body parts at a similar rate. All mothers assumed the same posture regardless of their role as initiator or receiver, with horizontal the most prevalent posture. Two maternal styles were found for PFC: high and low use of PFC. Within the high PFC group, there was individual variation that was related to calf sex. Even though evidence of maternal style was confirmed in PFC exchanges between adult female dolphins and their calves, the number of PFC shared between these kin was only ~9% of all documented PFC contacts (N = 4,345) over 16 years, suggesting that other forms of tactile contact may be more important within the confines of the mother-offspring relationship in delphinids.

The Stratospheric Aerosol and Gas Experiment III (SAGE III, 2018) instrument was launched on 19 February 2017 from the NASA Kennedy Space Center and was integrated aboard the International Space Station (ISS). SAGE III-ISS has been providing ozone profile measurements since June 2017. This paper presents an early validation of the Level 2 solar and lunar occultation ozone data products using ground-based lidar and ozonesondes from Hohenpeißenberg and Lauder as well as satellite ozone vertical products from the Atmospheric Chemistry Experiment Fourier Transform Spectrometer (ACE-FTS) instrument. Average differences in the ozone concentration between SAGE III-ISS and Hohenpeißenberg lidar observations for 1 year are less than 10 % between 16 and 42 km and less than 5 % between 20 and 40 km. Hohenpeißenberg ozonesonde comparisons are mostly within 10 % between 18 and 30 km. The Lauder lidar comparison results are less than 10 % between 17 and 37 km, and the Lauder ozonesonde comparison results are less than 10 % between 19 and 31 km. The seasonal average differences in the ozone concentration between SAGE III-ISS and ACE-FTS are mostly less than 5 % between 20 and 45 km for both the Northern Hemisphere and Southern Hemisphere. All results from these comparisons show that the SAGE III-ISS ozone solar data compare well with correlative measurements throughout the stratosphere. With few comparisons available, the percentage difference between the SAGE III-ISS lunar ozone data and the ozonesonde data is less than 10 % between 19 and 27 km. The percentage difference between the SAGE III-ISS lunar ozone data and the ACE-FTS ozone data is less than 10 % between 20 and 40 km.

We present analyses of 0.05–2 MeV ions from the 2022 February 16 energetic storm particle event observed by Parker Solar Probe's (PSP) IS⊙IS/EPI-Lo instrument at 0.35 au from the Sun. This event was characterized by an enhancement in ion fluxes from a quiet background, increasing gradually with time with a nearly flat spectrum, rising sharply near the arrival of the coronal mass ejection (CME)–driven shock, becoming nearly a power-law spectrum, then decaying exponentially afterward, with a rate that was independent of energy. From the observed fluxes, we determine diffusion coefficients, finding that far upstream of the shock the diffusion coefficients are nearly independent of energy, with a value of 10 ^20 cm ^2 s ^−1 . Near the shock, the diffusion coefficients are more than 1 order of magnitude smaller and increase nearly linearly with energy. We also determine the source of energetic particles, by comparing ratios of the intensities at the shock to estimates of the quiet-time intensity to predictions from diffusive shock acceleration theory. We conclude that the source of energetic ions is mostly the solar wind for this event. We also present potential interpretations of the near-exponential decay of the intensity behind the shock. One possibility we suggest is that the shock was overexpanding when it crossed PSP and the energetic particle intensity decreased behind the shock to fill the expanding volume. Overexpanding CMEs could well be more common closer to the Sun, and this is an example of such a case.

We use Parker Solar Probe (PSP) observations to report the first direct measurements of the particle and field environments while crossing the leg of a coronal mass ejection (CME) very close to the Sun (∼14 Rs). An analysis that combines imaging from 1 au and PSP with a CME model, predicts an encounter time and duration that correspond to an unusual, complete dropout in low-energy solar energetic ions from H–Fe, observed by the Integrated Science Investigation of the Sun (IS⊙IS). The surrounding regions are populated with low-intensity protons and heavy ions from 10s to 100 keV, typical of some quiet times close in to the Sun. In contrast, the magnetic field and solar wind plasma show no similarly abrupt changes at the boundaries of the dropout. Together, the IS⊙IS energetic particle observations, combined with remote sensing of the CME and a dearth of other “typical” CME signatures, indicate that this CME leg is significantly different from the magnetic and plasma structure normally assumed for CMEs near the Sun and observed in interplanetary CMEs farther out in the solar wind. The dropout in low-energy energetic ions may be due to the cooling of suprathermal ions at the base of the CME leg flux tube, owing to the rapid outward expansion during the release of the CME.

Energetic charged particles are pervasive throughout the heliosphere with contributions from solar energetic particle events, stream and corotating interaction regions, galactic cosmic rays, anomalous cosmic rays, and suprathermal ions. The Integrated Science Investigation of the Sun (IS⊙IS) on board the Parker Solar Probe is a suite of energetic particle detectors covering the energy range ∼20 keV–200 MeV nuc ^−1 . IS⊙IS measures energetic particles closer to the Sun than any instrument suite in history, providing a singular view of the energetic particle population in a previously unexplored region. To enable the global research community to efficiently use IS⊙IS data, we have developed an online living catalog of energetic particle enhancements observed by the IS⊙IS instruments. Event identification methodology, information on accessing the catalog, highlights of several events, and a summary of the overall trends are presented. Also included is a summary Event Catalog showing many of the key event parameters for IS⊙IS events to the time of writing.

Abstract Extracellular vesicles (EVs) are small, lipid-bound particles containing nucleic acid and protein cargo which are excreted from cells under a variety of normal and pathological conditions. EVs have garnered substantial research interest in recent years, due to their potential utility as circulating biomarkers for a variety of diseases, including numerous types of cancer. The following review will discuss the current understanding of the form and function of EVs, their specific role in cancer pathogenesis and their potential for non-invasive disease diagnosis and/or monitoring. This review will also highlight several key issues for this field, including the importance of implementing robust and reproducible sample handling protocols, and the challenge of extracting an EV-specific biomarker signal from a complex biological background.

The glucose and dehydroascorbic acid (DHA) transporter GLUT1 contains a phosphorylation site, S490, for ataxia telangiectasia mutated (ATM). The objective of this study was to determine whether ATM and GLUT1-S490 regulate GLUT1.L6 myoblasts and mouse skeletal muscles were used to study the effects of ATM inhibition, ATM activation, and S490 mutation on GLUT1 localization, trafficking, and transport activity.In myoblasts, inhibition of ATM significantly diminished cell surface GLUT1, glucose and DHA transport, GLUT1 externalization, and association of GLUT1 with Gα-interacting protein-interacting protein, C-terminus (GIPC1), which has been implicated in recycling of endosomal proteins. In contrast, ATM activation by doxorubicin (DXR) increased DHA transport, cell surface GLUT1, and the GLUT1/GIPC1 association. S490A mutation decreased glucose and DHA transport, cell surface GLUT1, and interaction of GLUT1 with GIPC1, while S490D mutation increased transport, cell surface GLUT1, and the GLUT1/GIPC1 interaction. ATM dysfunction or ATM inhibition reduced DHA transport in extensor digitorum longus (EDL) muscles and decreased glucose transport in EDL and soleus. In contrast, DXR increased DHA transport in EDL.These results provide evidence that ATM and GLUT1-S490 promote cell surface GLUT1 and GLUT1-mediated transport in skeletal muscle associated with upregulation of the GLUT1/GIPC1 interaction.

The conceptual design for a nonscaling fixed field alternating gradient accelerator suitable for charged particle therapy (the use of protons and other light ions to treat some forms of cancer) is described.