119 results on '"M. Maple"'
Search Results
2. Acute sleep deprivation upregulates serotonin 2A receptors in the frontal cortex of mice via the immediate early gene Egr3
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Xiuli Zhao, Annika B. Ozols, Kimberly T. Meyers, Janet Campbell, Andrew McBride, Ketan K. Marballi, Amanda M. Maple, Carren Raskin, Abhinav Mishra, Serena M. Noss, Kelsey L. Beck, Rami Khoshaba, Amulya Bhaskara, Meghna N. Godbole, James R. Lish, Paul Kang, Chengcheng Hu, Mikael Palner, Agnete Overgaard, Gitte M. Knudsen, and Amelia L. Gallitano
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Mice ,Serotonin ,Cellular and Molecular Neuroscience ,Psychiatry and Mental health ,Animals ,Sleep Deprivation ,Receptor, Serotonin, 5-HT2A ,RNA, Messenger ,Early Growth Response Protein 3 ,Genes, Immediate-Early ,Molecular Biology ,Frontal Lobe - Abstract
Serotonin 2A receptors (5-HT
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- 2022
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3. SDG5 Gender Equality during the COVID-19 pandemic: an international comparative policy assessment
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E Kuhlmann, G Lotta, M Fernandez, A Herten-Crabb, J-M Maple, L MacFehr, L Paina, C Wenham, and K Willis
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Public Health, Environmental and Occupational Health - Abstract
Background The COVID-19 pandemic caused severe disruptions in healthcare systems and societies and exacerbated existing inequalities for women and girls across every sphere. Our study explores health systems responses to gender equality goals during the COVID-19 pandemic and which role these goals play in pandemic recovery policies. Methods We apply a qualitative comparative approach. Country case studies (expert information, secondary sources) were collected in March/April 2022. The sample comprised Australia, Brazil, Germany, United Kingdom and USA, reflecting conditions of high to upper-middle income countries with established public health systems, democratic political institutions and gender equality policies. Selected topics: maternity care/reproductive services, violence against women, and gender equality/female leadership. Results All countries tried to keep essential maternity and reproductive services open, but strong limitations applied especially for prevention and counselling services; at the same time, digitalisation/telemedicine supported service expansion. Violence against women and children strongly increased during the pandemic. Routine services were partly kept open and new helplines occasionally established, but no action was taken to scale-up mental health support and respond to new demand. A push-back of gender equality was observed across countries in all areas of health and social care, often coupled with strong increase in intersecting social inequalities; participation of women in decision-making bodies was generally weak and not monitored. Conclusions Across countries, gender equality policies cracked under the pressure of the COVID-19 pandemic; this is true for countries with male and female political leaders, and for different areas of SDG5 and health. There is an urgent need for more effective intersectional gender equality policies and improved participation of women in global health and in health system recovery plans. Key messages • Health systems failed to take action to protect SDG5 goals; gender and intersecting inequalities strongly increased during the pandemic. • Building back better after COVID-19 will only be possible with an intersectional gender equality programme and feminist policy approaches.
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- 2022
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4. Activity-regulated cytoskeleton-associated protein predicts symptom response to cognitive behavioral therapy among individuals with first-episode psychosis
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Nicholas J K Breitborde, Aubrey M. Moe, Jacob G. Pine, Amelia L. Gallitano, and Amanda M. Maple
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Treatment outcome ,MEDLINE ,Nerve Tissue Proteins ,Young Adult ,First episode psychosis ,medicine ,Humans ,Young adult ,Psychiatry ,General Psychology ,Cognitive Behavioral Therapy ,business.industry ,General Medicine ,Prognosis ,Cognitive behavioral therapy ,Psychiatry and Mental health ,Cytoskeletal Proteins ,Treatment Outcome ,Psychotic Disorders ,Female ,business - Published
- 2019
5. Sleep deprivation rapidly upregulates serotonin 2A receptor expression via the immediate early gene Egr3
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X. Zhao, K. T. Meyers, A. McBride, K. K. Marballi, A. M. Maple, K. L. Beck, P. Kang, M. Palner, A. Overgaard, G. M. Knudsen, and A. L. Gallitano
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0303 health sciences ,Stimulus (physiology) ,Biology ,medicine.disease ,In vitro ,Cell biology ,03 medical and health sciences ,0302 clinical medicine ,Downregulation and upregulation ,In vivo ,Schizophrenia ,medicine ,Binding site ,Immediate early gene ,Transcription factor ,030217 neurology & neurosurgery ,030304 developmental biology - Abstract
Serotonin 2A receptors (5-HT2ARs) mediate the effects of hallucinogenic drugs and antipsychotic medications, and are reduced in schizophrenia patients’ brains. However, the mechanisms that regulate 5-HT2AR expression remain poorly understood. We show that an environmental stimulus, sleep deprivation, upregulates 5-HT2ARs in the mouse frontal cortex (FC) in just 6-8 hours. This induction requires the immediate early gene transcription factor early growth response 3 (Egr3). Further, EGR3 binds to the Htr2a promoter in the FC in vivo, and drives reporter construct expression in vitro via two Htr2a promoter binding sites. These findings suggest that EGR3 directly regulates FC Htr2a expression in response to physiologic stimuli, providing a mechanism by which environment rapidly alters levels of a brain receptor that mediates symptoms, and treatment, of mental illness.One Sentence SummaryJust 6-8 hours of sleep deprivation upregulates brain levels of the receptor that mediates the response to hallucinogens.
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- 2019
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6. Activity-regulated cytoskeleton-associated protein predicts response to cognitive remediation among individuals with first-episode psychosis
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Emily K. Bell, Amanda M. Maple, Cindy Woolverton, Nicholas J K Breitborde, Spencer C. Dawson, Patricia Harrison-Monroe, and Amelia L. Gallitano
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,MEDLINE ,Nerve Tissue Proteins ,Polymorphism, Single Nucleotide ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Polymorphism (computer science) ,First episode psychosis ,medicine ,Humans ,RNA, Messenger ,Young adult ,Psychiatry ,Biological Psychiatry ,Chi-Square Distribution ,Follow up studies ,Cognitive Remediation ,Ether-A-Go-Go Potassium Channels ,030227 psychiatry ,Cytoskeletal Proteins ,Psychiatry and Mental health ,Gene Expression Regulation ,Psychotic Disorders ,Cognitive remediation therapy ,Female ,Psychology ,Chi-squared distribution ,030217 neurology & neurosurgery ,Follow-Up Studies - Published
- 2017
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7. Influence of Schizophrenia-Associated Gene Egr3 on Sleep Behavior and Circadian Rhythms in Mice
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Amelia L. Gallitano, Rachel K. Rowe, Fabian Fernandez, Amanda M. Maple, and Jonathan Lifshitz
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Physiology ,Population ,Constant darkness ,Motor Activity ,Article ,03 medical and health sciences ,Mice ,0302 clinical medicine ,Physiology (medical) ,Medicine ,Animals ,Circadian rhythm ,education ,Gene ,Constant light ,Early Growth Response Protein 3 ,Mice, Knockout ,education.field_of_study ,business.industry ,Darkness ,030227 psychiatry ,Circadian Rhythm ,Sleep behavior ,Schizophrenia ,Female ,Entrainment (chronobiology) ,business ,Sleep ,Immediate early gene ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Up to 80% of people meeting DSM-IV definitions for schizophrenia will exhibit difficulties with sleep, along with a breakdown in circadian entrainment and rhythmicity. The changes to the sleep and circadian systems in this population are thought to be interdependent, as evidenced by the frequent use of the combined term “sleep and circadian rhythm disruption” or “SCRD” to describe their occurrence. To understand links between sleep and circadian problems in the schizophrenia population, we analyzed the duration and rhythmicity of sleep behavior in mice lacking function of the immediate early gene early growth response 3 ( Egr3). EGR3 has been associated with schizophrenia risk in humans, and Egr3-deficient (-/-) mice display various features of schizophrenia that are responsive to antipsychotic treatment. While Egr3-/- mice slept less than their wildtype (WT) littermates, they showed no evidence of circadian disorganization; in fact, circadian rhythms of activity were more robust in these mice compared with WT, as measured by time series analysis and the relative amplitude index of Van Someren’s suite of non-parametric circadian rhythm analyses. Differences in circadian robustness were maintained when the animals were transferred to several weeks of housing under constant darkness or constant light. Together, our results suggest that Egr3-/- mice retain control over the circadian timekeeping of sleep and wake, while showing impaired sleep. The findings are compatible with those from a surprising array of mouse models of schizophrenia and raise the possibility that SCRD may be 2 separate disorders in the schizophrenia population requiring different treatment strategies.
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- 2018
8. Attenuated Late-Phase Arc Transcription in the Dentate Gyrus of Mice Lacking Egr3
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Amanda M. Maple, Rachel E. Lackie, Collin Xa, Diana I. Elizalde, Amelia L. Gallitano, Stephanie L. Grella, Diano F. Marrone, and Chelsey C. Damphousse
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0301 basic medicine ,medicine.diagnostic_test ,Article Subject ,Dentate gyrus ,Stimulation ,Biology ,Cell biology ,lcsh:RC321-571 ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Neurology ,Transcription (biology) ,Late phase ,Time course ,medicine ,Neurology (clinical) ,Early Growth Response Protein 3 ,Cytoskeleton ,Neuroscience ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,030217 neurology & neurosurgery ,Fluorescence in situ hybridization - Abstract
The dentate gyrus (DG) engages in sustainedArctranscription for at least 8 hours following behavioral induction, and this time course may be functionally coupled to the unique role of the DG in hippocampus-dependent learning and memory. The factors that regulate long-term DGArcexpression, however, remain poorly understood. Animals lackingEgr3show lessArcexpression following convulsive stimulation, but the effect ofEgr3ablation on behaviorally inducedArcremains unknown. To address this,Egr3−/−and wild-type (WT) mice explored novel spatial environments and were sacrificed either immediately or after 5, 60, 240, or 480 minutes, andArcexpression was quantified by fluorescence in situ hybridization. Although short-term (i.e., within 60 min)Arcexpression was equivalent across genotypes, DGArcexpression was selectively reduced at 240 and 480 minutes in mice lackingEgr3. These data demonstrate the involvement ofEgr3in regulating the late protein-dependent phase ofArcexpression in the DG.
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- 2017
9. Neuronal reorganization in adult rats neonatally exposed to (±)-3,4-methylenedioxymethamphetamine
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Matthew R. Skelton, Kimberly N. Huggins, Charles V. Vorhees, Amanda M. Maple, Michael T. Williams, Russell W. Brown, and Ian D. Longacre
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medicine.medical_specialty ,EC, entorhinal cortex ,Health, Toxicology and Mutagenesis ,Biology ,Nucleus accumbens ,Development ,Toxicology ,Article ,Golgi–Cox staining ,Neurochemical ,lcsh:RA1190-1270 ,Internal medicine ,mental disorders ,medicine ,Dentate gyrus ,Psychiatry ,5-HT receptor ,5-HT, serotonin ,ANOVA, analysis of variance ,lcsh:Toxicology. Poisons ,SAL, saline ,Entorhinal cortex ,P, postnatal day ,DG, dentate gyrus ,MDMA ,CWM, Cincinnati water maze ,Endocrinology ,MWM, Morris water maze ,Gestation ,Serotonin ,NAcc, nucleus accumbens ,psychological phenomena and processes ,MDMA, methylenedioxymethamphetamine ,medicine.drug - Abstract
The abuse of methylenedioxymethamphetamine (MDMA) during pregnancy is of concern. MDMA treatment of rats during a period of brain growth analogous to late human gestation leads to neurochemical and behavioral changes. MDMA from postnatal day (P)11–20 in rats produces reductions in serotonin and deficits in spatial and route-based navigation. In this experiment we examined the impact of MDMA from P11 to P20 (20 mg/kg twice daily, 8 h apart) on neuronal architecture. Golgi impregnated sections showed significant changes. In the nucleus accumbens, the dendrites were shorter with fewer spines, whereas in the dentate gyrus the dendritic length was decreased but with more spines, and for the entorhinal cortex, reductions in basilar and apical dendritic lengths in MDMA animals compared with saline animals were seen. The data show that neuronal cytoarchitectural changes are long-lasting following developmental MDMA exposure and are in regions consistent with the learning and memory deficits observed in such animals.
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- 2014
10. The Jovian Auroral Distributions Experiment (JADE) on the Juno Mission to Jupiter
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N. Alexander, d. T. Everett, Tiffany J. Finley, B. Rodriguez, George Clark, J. Johnson, R.D. Hill, M. Maple, Fran Bagenal, P. Louarn, C. Loeffler, Daniel Santos-Costa, A. Gribanova, M. Reno, David J. McComas, Robert Wilson, J. Dickinson, F. J. Crary, Phil Valek, W. Mills, Craig J. Pollock, D. White, Frederic Allegrini, P. Wilson, Chip R. Beebe, A. De Los Santos, M. I. Desai, Jean-Noël Rouzaud, C. Kofoed, S. Weidner, and D. Demkee
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Physics ,010504 meteorology & atmospheric sciences ,Spacecraft ,business.industry ,Magnetosphere ,Astronomy ,Astronomy and Astrophysics ,Field of view ,01 natural sciences ,JADE (particle detector) ,Jovian ,Jupiter ,Planetary science ,Exploration of Jupiter ,Space and Planetary Science ,0103 physical sciences ,business ,010303 astronomy & astrophysics ,0105 earth and related environmental sciences - Abstract
The Jovian Auroral Distributions Experiment (JADE) on Juno provides the critical in situ measurements of electrons and ions needed to understand the plasma energy particles and processes that fill the Jovian magnetosphere and ultimately produce its strong aurora. JADE is an instrument suite that includes three essentially identical electron sensors (JADE-Es), a single ion sensor (JADE-I), and a highly capable Electronics Box (EBox) that resides in the Juno Radiation Vault and provides all necessary control, low and high voltages, and computing support for the four sensors. The three JADE-Es are arrayed 120∘ apart around the Juno spacecraft to measure complete electron distributions from ∼0.1 to 100 keV and provide detailed electron pitch-angle distributions at a 1 s cadence, independent of spacecraft spin phase. JADE-I measures ions from ∼5 eV to ∼50 keV over an instantaneous field of view of 270∘×90∘ in 4 s and makes observations over all directions in space each 30 s rotation of the Juno spacecraft. JADE-I also provides ion composition measurements from 1 to 50 amu with m/Δm∼2.5, which is sufficient to separate the heavy and light ions, as well as O+ vs S+, in the Jovian magnetosphere. All four sensors were extensively tested and calibrated in specialized facilities, ensuring excellent on-orbit observations at Jupiter. This paper documents the JADE design, construction, calibration, and planned science operations, data processing, and data products. Finally, the Appendix describes the Southwest Research Institute [SwRI] electron calibration facility, which was developed and used for all JADE-E calibrations. Collectively, JADE provides remarkably broad and detailed measurements of the Jovian auroral region and magnetospheric plasmas, which will surely revolutionize our understanding of these important and complex regions.
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- 2013
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11. Helium, Oxygen, Proton, and Electron (HOPE) Mass Spectrometer for the Radiation Belt Storm Probes Mission
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Ruth M. Skoug, Michelle F. Thomsen, Kevin Henderson, Jennifer Hanley, J.-M. Jahn, A. D. Puckett, E. Edlund, Reiner Friedel, James Lake, R. W. Harper, Brian A. Larsen, M. Freeman, J. R. Baldonado, K. H. Kihara, Herbert O. Funsten, C. Urdiales, Elizabeth MacDonald, Harlan E. Spence, A. De Los Santos, J. T. Niehof, Jie Chen, G. Dunn, Michael G. Henderson, J. A. Cravens, Geoffrey D. Reeves, A. A. Guthrie, L. L. Suther, M. Maple, M. Ferris, W. Toczynski, D. E. George, C. Nunez, S. Cortinas, V. J. Vigil, and T. Taylor
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Physics ,Proton ,Spacecraft ,business.industry ,Astronomy and Astrophysics ,Electron ,Mass spectrometry ,Ion ,symbols.namesake ,Space and Planetary Science ,Van Allen radiation belt ,Physics::Space Physics ,symbols ,Van Allen Probes ,Astrophysical plasma ,Astrophysics::Earth and Planetary Astrophysics ,Atomic physics ,business - Abstract
The HOPE mass spectrometer of the Radiation Belt Storm Probes (RBSP) mission (renamed the Van Allen Probes) is designed to measure the in situ plasma ion and electron fluxes over 4π sr at each RBSP spacecraft within the terrestrial radiation belts. The scientific goal is to understand the underlying physical processes that govern the radiation belt structure and dynamics. Spectral measurements for both ions and electrons are acquired over 1 eV to 50 keV in 36 log-spaced steps at an energy resolution ΔE FWHM/E≈15 %. The dominant ion species (H+, He+, and O+) of the magnetosphere are identified using foil-based time-of-flight (TOF) mass spectrometry with channel electron multiplier (CEM) detectors. Angular measurements are derived using five polar pixels coplanar with the spacecraft spin axis, and up to 16 azimuthal bins are acquired for each polar pixel over time as the spacecraft spins. Ion and electron measurements are acquired on alternate spacecraft spins. HOPE incorporates several new methods to minimize and monitor the background induced by penetrating particles in the harsh environment of the radiation belts. The absolute efficiencies of detection are continuously monitored, enabling precise, quantitative measurements of electron and ion fluxes and ion species abundances throughout the mission. We describe the engineering approaches for plasma measurements in the radiation belts and present summaries of HOPE measurement strategy and performance.
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- 2013
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12. Schizophrenia and Substance Abuse Comorbidity: Nicotine Addiction and the Neonatal Quinpirole Model
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Zackary A. Cope, A. Brianna Sheppard, Richard M. Kostrzewa, Amanda M. Maple, Russell W. Brown, and Marla K. Perna
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Nicotine ,medicine.medical_specialty ,Quinpirole ,media_common.quotation_subject ,Population ,Neurochemical ,Developmental Neuroscience ,mental disorders ,medicine ,Animals ,education ,Psychiatry ,media_common ,education.field_of_study ,Addiction ,Anhedonia ,Tobacco Use Disorder ,medicine.disease ,Behavior, Addictive ,Substance abuse ,Disease Models, Animal ,Neurology ,Schizophrenia ,medicine.symptom ,Psychology ,medicine.drug ,Clinical psychology - Abstract
This review focuses on nicotine comorbidity in schizophrenia, and the insight into this problem provided by rodent models of schizophrenia. A particular focus is on age differences in the response to nicotine, and how this relates to the development of the disease and difficulties in treatment. Schizophrenia is a particularly difficult disease to model in rodents due to the fact that it has a plethora of symptoms ranging from paranoia and delusions of grandeur to anhedonia and negative affect. The basis of these symptoms is believed to be due to neurochemical abnormalities and neuropathology in the brain, which most models have attempted to emulate. A brief review of findings regarding nicotine use and abuse in schizophrenics is presented, with findings using rodent models that have been able to provide insight into the mechanisms of addiction. A common clinical approach to the treatment of nicotine addiction in the schizophrenic population has been that these drugs are used for self-medication purposes, and it is clear that self-medication may actually be directed at several symptoms, including cognitive impairment and anhedonia. Finally, our laboratory has reported across a series of studies that neonatal treatment with the dopamine D2/D3 receptor agonist quinpirole results in long-term increases in dopamine-like receptor sensitivity, consistent with data reporting increases in dopamine D2 receptor function in schizophrenia. Across these studies, we have reported several behavioral, neurochemical, and genetic consistencies with the disease, and present a hypothesis for what we believe to be the basis of psychostimulant addiction in schizophrenia.
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- 2012
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13. The Interstellar Boundary Explorer High Energy (IBEX-Hi) Neutral Atom Imager
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M. Granoff, Phil Valek, M. J. Fagan, Peter Bochsler, B. Rodriguez, K. H. Kihara, Jennifer Hanley, Peter Wurz, L. Saul, G. Dunn, d. T. Everett, S. Turco, Harald Kucharek, Mike Gruntman, M. P. Manzo, Herbert O. Funsten, K. Mashburn, M. Maple, J. Nolin, Frederic Allegrini, S. Weidner, Eberhard Moebius, D. Heirtzler, R. W. Harper, Daniel B. Reisenfeld, S. Zaffke, P. H. Janzen, Stephen A. Fuselier, S. Pope, A. A. Guthrie, B. King, S. Ellis, Daniele Piazza, Edmond C. Roelof, and David J. McComas
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Physics ,Range (particle radiation) ,Energetic neutral atom ,media_common.quotation_subject ,Ecliptic ,Astronomy ,Astronomy and Astrophysics ,Interstellar medium ,Space and Planetary Science ,Sky ,Ionization ,Physics::Space Physics ,Noise (radio) ,Heliosphere ,media_common - Abstract
The IBEX-Hi Neutral Atom Imager of the Interstellar Boundary Explorer (IBEX) mission is designed to measure energetic neutral atoms (ENAs) originating from the interaction region between the heliosphere and the local interstellar medium (LISM). These ENAs are plasma ions that have been heated in the interaction region and neutralized by charge exchange with the cold neutral atoms of the LISM that freely flow through the interaction region. IBEX-Hi is a single pixel ENA imager that covers the ENA spectral range from 0.38 to 6 keV and shares significant energy overlap and overall design philosophy with the IBEX-Lo sensor. Because of the anticipated low flux of these ENAs at 1 AU, the sensor has a large geometric factor and incorporates numerous techniques to minimize noise and backgrounds. The IBEX-Hi sensor has a field-of-view (FOV) of 6.5°×6.5° FWHM, and a 6.5°×360° swath of the sky is imaged over each spacecraft spin. IBEX-Hi utilizes an ultrathin carbon foil to ionize ENAs in order to measure their energy by subsequent electrostatic analysis. A multiple coincidence detection scheme using channel electron multiplier (CEM) detectors enables reliable detection of ENAs in the presence of substantial noise. During normal operation, the sensor steps through six energy steps every 12 spacecraft spins. Over a single IBEX orbit of about 8 days, a single 6.5°×360° swath of the sky is viewed, and re-pointing of the spin axis toward the Sun near perigee of each IBEX orbit moves the ecliptic longitude by about 8° every orbit such that a full sky map is acquired every six months. These global maps, covering the spectral range of IBEX-Hi and coupled to the IBEX-Lo maps at lower and overlapping energies, will answer fundamental questions about the structure and dynamics of the interaction region between the heliosphere and the LISM.
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- 2009
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14. Nicotine sensitization in adult male and female rats quinpirole-primed as neonates
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Amanda M. Maple, Zackary A. Cope, Jennifer A. Correll, Ian D. Longacre, Marla K. Perna, and Russell W. Brown
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Male ,Nicotine ,medicine.medical_specialty ,Quinpirole ,Population ,Motor Activity ,Dopamine agonist ,Rats, Sprague-Dawley ,Sex Factors ,Dopamine ,Dopamine receptor D2 ,Internal medicine ,Administration, Inhalation ,medicine ,Animals ,education ,Sensitization ,Pharmacology ,education.field_of_study ,Dose-Response Relationship, Drug ,Receptors, Dopamine D2 ,business.industry ,Brain ,Rats ,medicine.anatomical_structure ,Endocrinology ,Animals, Newborn ,Dopamine receptor ,Exploratory Behavior ,Female ,Yawning ,business ,Injections, Intraperitoneal ,medicine.drug - Abstract
Increases in dopamine D2-like receptor function are common in several psychological disorders that demonstrate a four to five fold increase in nicotine abuse compared to the general population.The objective of this study was to analyze the interaction of sex differences and sensitization to nicotine in rats D2 receptor primed as neonates.A total of 32 male and 32 female Sprague-Dawley rats derived from eight litters were ontogenetically treated with quinpirole (1 mg/kg) or saline from postnatal days (P) 1-21 and raised to adulthood. At P60, all animals were given an acute injection of quinpirole HCl (100 microg/kg) and yawns were counted for 1 h. Yawning has been shown to be a behavioral event mediated by D2-like receptors. Beginning on P61-65, animals were habituated to a locomotor arena and subsequently administered either nicotine (0.5 mg/kg free base) or saline (intraperitoneal) every second day for 3 weeks. Approximately 15 min after each injection, animals were placed into the arena and horizontal activity and vertical rears were recorded.A robust increase of yawning was observed at P60 in D2 primed as compared to saline controls. Priming of D2-like receptors increased the locomotor response to nicotine in horizontal activity in both males and females, but females demonstrated a more robust hypoactive locomotor response to initial nicotine treatment when compared to saline-treated females. Nicotine also produced a significant decrease of vertical rearing in both males and females.It appears that D2 receptor priming enhances sensitization to nicotine in adult rats, and females may be more behaviorally sensitive to nicotine than males.
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- 2008
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15. Adulthood olanzapine treatment fails to alleviate decreases of ChAT and BDNF RNA expression in rats quinpirole-primed as neonates
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Marla K. Perna, Russell W. Brown, Barney E. Miller, Amanda M. Maple, and Tracy D. Wilson
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Male ,Agonist ,Olanzapine ,Aging ,medicine.medical_specialty ,Quinpirole ,medicine.drug_class ,Down-Regulation ,Morris water navigation task ,Atypical antipsychotic ,Hippocampus ,Choline O-Acetyltransferase ,Time ,Rats, Sprague-Dawley ,Benzodiazepines ,Cognition ,Dopamine ,Internal medicine ,medicine ,Animals ,Hippocampus (mythology) ,RNA, Messenger ,Maze Learning ,Molecular Biology ,Brain-derived neurotrophic factor ,Learning Disabilities ,Receptors, Dopamine D2 ,Brain-Derived Neurotrophic Factor ,General Neuroscience ,Acetylcholine ,Rats ,Endocrinology ,Animals, Newborn ,Dopamine Agonists ,Female ,Neurology (clinical) ,Cognition Disorders ,Psychology ,Neuroscience ,Antipsychotic Agents ,Developmental Biology ,medicine.drug - Abstract
Neonatal quinpirole (dopamine D(2)/D(3) agonist) treatment to rats has been shown to increase dopamine D(2) receptor sensitivity throughout the animal's lifetime. Male and female Sprague-Dawley rats were neonatalally treated with quinpirole (1 mg/kg) from postnatal days (P) 1-21 and raised to adulthood. Beginning on P62, rats were administered the atypical antipsychotic olanzapine (2.5 mg/kg) twice daily for 28 days. Starting 1 day after the end of olanzapine treatment, animals were behaviorally tested on the place and match-to-place version of the Morris water maze (MWM) over seven consecutive days, and a yawning behavioral test was also performed to test for sensitivity of the D(2) receptor 1 day following MWM testing. Similar to results from a past study, olanzapine alleviated cognitive impairment on the MWM place version and increases in yawning produced by neonatal quinpirole treatment. Brain tissue analyses showed that neonatal quinpirole treatment resulted in a significant decrease of hipppocampal ChAT and BDNF RNA expression that were unaffected by adulthood olanzapine treatment, although adulthood olanzapine treatment produced a significant increase in cerebellar ChAT RNA expression. There were no significant effects of drug treatment on NGF RNA expression in any brain area. These results show that neonatal quinpirole treatment produced significant decreases of protein RNA expression that is specific to the hippocampus. Although olanzapine alleviated cognitive deficits produced by neonatal quinpirole treatment, it did not affect expression of proteins known to be important in cognitive performance.
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- 2008
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16. Ontogenetic quinpirole treatment produces long-lasting decreases in the expression of Rgs9, but increases Rgs17 in the striatum, nucleus accumbens and frontal cortex
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Joshua P. Parlaman, Gregg D. Stanwood, Amanda M. Maple, Russell W. Brown, and Marla K. Perna
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Agonist ,medicine.medical_specialty ,medicine.drug_class ,General Neuroscience ,Striatum ,In situ hybridization ,Biology ,Nucleus accumbens ,Quinpirole ,Endocrinology ,Dopamine ,Internal medicine ,medicine ,RGS9 ,Receptor ,medicine.drug - Abstract
Ontogenetic treatment of rats with the dopamine D(2)-like receptor agonist quinpirole produces a significant increase in dopamine D(2) receptor sensitivity that persists throughout the animal's lifetime, a phenomenon known as D(2) priming. The present study was designed to investigate the effects of priming of the D(2) receptor on the expression of three different members of the regulator of G-protein signaling (RGS) family: Rgs4, Rgs9 and Rgs17. Male offspring were ontogenetically treated with quinpirole or saline from postnatal days (P)1-21 and raised to adulthood. On approximately P65, animals were given an acute quinipirole injection (0.1 mg/kg) and the number of yawns was recorded for 1 h after the injection. Yawning has been shown to be a behavioural event mediated by the dopamine D(2)/D(3) receptor. Animals ontogenetically treated with quinpirole demonstrated a significant 2.5-fold increase in yawning as compared to controls. Rgs transcripts were analysed through in situ hybridization several weeks later. Rats ontogenetically treated with quinpirole demonstrated a significant decrease in Rgs9 expression in the frontal cortex, but a more robust decrease in the striatum and nucleus accumbens as compared to controls. Regarding Rgs17, ontogenetic quinpirole produced a modest but significant increase in expression in the same brain areas. There were no significant differences in Rgs4 expression produced by drug treatment in any of the brain regions analysed. This study demonstrates that ontogenetic quinpirole treatment, which results in priming of the D(2) receptor, results in significant decreases in Rgs9, which has been shown to regulate G-protein coupling to D(2) receptors.
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- 2007
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17. Neonatal quinpirole treatment produces prepulse inhibition deficits in adult male and female rats
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Marla K. Perna, Amanda M. Maple, Russell W. Brown, and Katherine J. Smith
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Agonist ,Male ,medicine.medical_specialty ,Quinpirole ,medicine.drug_class ,Clinical Biochemistry ,Toxicology ,Biochemistry ,Rats, Sprague-Dawley ,Behavioral Neuroscience ,Dopamine ,Dopamine receptor D2 ,Internal medicine ,medicine ,Animals ,Receptor ,Biological Psychiatry ,Prepulse inhibition ,Pharmacology ,Sensory gating ,Prepulse Inhibition ,Interstimulus interval ,Age Factors ,Sensory Gating ,Rats ,Endocrinology ,medicine.anatomical_structure ,Acoustic Stimulation ,Animals, Newborn ,Dopamine Agonists ,Female ,Yawning ,Psychology ,medicine.drug - Abstract
We have shown that repeated neonatal quinpirole (QUIN; a dopamine D2-like receptor agonist) treatment in rats produces long-lasting supersensitization of dopamine D2 receptors that persists into adulthood but without producing a change in receptor number. The current study was designed to analyze the effects of neonatal QUIN on auditory sensorimotor gating as measured through prepulse inhibition (PPI). Male and female Sprague-Dawley rats were neonatally treated with QUIN (1mg/kg) or saline from postnatal days (P)1-21. At P60, the number of yawns was recorded for a 1h period in response to an acute QUIN (1mg/kg) injection as yawning is a D2-like receptor mediated behavioral event. Five days later, rats began (PPI) behavioral testing in two phases. In phase I, three different prepulse intensities (73, 76, and 82dB) were administered 100-ms before a 115dB pulse on 10 consecutive days. In phase II, three different interstimulus intervals (ISI; 50, 100, and 150ms) were inserted between the 73 or 76dB prepulse and 115dB pulse over 10 consecutive days of testing. A PPI probe trial was administered at the end of each phase after an acute 100μg/kgi.p. injection of QUIN to all animals. Replicating previous work, neonatal QUIN enhanced yawning compared to controls, verifying D2 receptor supersensitization. Regarding PPI, neonatal QUIN resulted in deficits across both phases of testing persistent across all testing days. Probe trial results revealed that acute QUIN treatment resulted in more robust PPI deficits in neonatal QUIN animals, although this deficit was related to prepulse intensity and ISI. These findings provide evidence that neonatal QUIN treatment results in deficits of auditory sensorimotor gating in adulthood as measured through PPI.
- Published
- 2015
18. Htr2a Expression Responds Rapidly to Environmental Stimuli in an Egr3-Dependent Manner
- Author
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Amanda M. Maple, Andrew McBride, Diana I. Elizalde, Xiuli Zhao, and Amelia L. Gallitano
- Subjects
Male ,Candidate gene ,medicine.medical_specialty ,Physiology ,Cognitive Neuroscience ,Green Fluorescent Proteins ,Mice, Transgenic ,Real-Time Polymerase Chain Reaction ,Biochemistry ,Article ,Internal medicine ,Genetic predisposition ,medicine ,Animals ,Receptor, Serotonin, 5-HT2A ,RNA, Messenger ,Receptor ,Early Growth Response Protein 3 ,Cerebral Cortex ,Mice, Knockout ,Cell Biology ,General Medicine ,medicine.disease ,Immunohistochemistry ,Mice, Inbred C57BL ,Sleep deprivation ,Disease Models, Animal ,medicine.anatomical_structure ,Endocrinology ,Cerebral cortex ,Schizophrenia ,Acute Disease ,Sleep Deprivation ,medicine.symptom ,Psychology ,Immediate early gene ,Stress, Psychological - Abstract
Pharmacologic and genetic findings have implicated the serotonin 2A receptor (5-HT2AR) in the etiology of schizophrenia. Recent studies have shown reduced 5-HT2AR levels in schizophrenia patients, yet the cause of this difference is unknown. Environmental factors, such as stress, also influence schizophrenia risk, yet little is known about how environment may affect this receptor. To determine if acute stress alters 5-HT2AR expression, we examined the effect of sleep deprivation on cortical Htr2a mRNA in mice. We found that 6 hours of sleep deprivation induces a 2-fold increase in Htr2a mRNA, a more rapid effect than has been previously reported. This effect requires the immediate early gene early growth response 3 (Egr3), as sleep deprivation failed to induce Htr2a expression in Egr3−/− mice. These findings provide a functional link between two schizophrenia candidate genes and an explanation of how environment may influence a genetic predisposition for schizophrenia.
- Published
- 2015
19. Performances of CYTOPTM low-k dielectric layer bridged GaAs-based enhancement mode pHEMT for wireless power application
- Author
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M.J. Jennison, M. Bramlett, S.D. Strathman, C. Wilhelmi, F.K. Oshita, J. Wei, C.H. Lin, P.C. Chang, R. Parkhurst, and M. Maple
- Subjects
Power gain ,Power-added efficiency ,Materials science ,Passivation ,business.industry ,Transistor ,Electrical engineering ,Low-k dielectric ,Dielectric ,High-electron-mobility transistor ,Condensed Matter Physics ,Electronic, Optical and Magnetic Materials ,law.invention ,law ,Materials Chemistry ,Dissipation factor ,Optoelectronics ,Electrical and Electronic Engineering ,business - Abstract
Cyclized-perfluoropolymer, which is commercialized under the trade name CYTOPTM, possesses the desirable properties of low dielectric constant (er = 2.1) and low dissipation factor (tan δ = 0.0007). We have developed a method to integrate CYTOPTM dielectric interlayer with state-of-the-art power GaAs-based enhancement mode pseudomorphic high electron mobility transistor. CYTOPTM thin films with approximately 3.5 μm in thickness was spin-coated and patterned on wafers with completed transistor and nitride passivation processes. Au-based interconnect metal was then fabricated using sputtering and plating processes over the CYTOPTM dielectric layer. The whole integrated structure was found to be stable at annealing temperatures up to 200 °C. Moreover, output power, gain, and power added efficiency of the CYTOPTM-integrated 0.5 μm gate transistor was measured and compared with standard air-bridged devices. The studies show that the CYTOPTM low-k dielectric layer has negligible effect on the device performances as compared with the air-bridged devices.
- Published
- 2005
- Full Text
- View/download PDF
20. Erythromycin serum concentrations following administration in acid-resistant tablets
- Author
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W M M, KIRBY, F M, MAPLE, and B, O'LEARY
- Subjects
Humans ,Erythromycin ,Tablets - Published
- 2014
21. Serum concentrations of erythromycin following intravenous administration
- Author
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F M, MAPLE, B, O'LEARY, and W M, KIRBY
- Subjects
Humans ,Administration, Intravenous ,Infusions, Intravenous ,Erythromycin - Published
- 2014
22. The Jovian Auroral Distributions Experiment (JADE) on the Juno Mission to Jupiter
- Author
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D. J. McComas, N. Alexander, F. Allegrini, F. Bagenal, C. Beebe, G. Clark, F. Crary, M. I. Desai, A. De Los Santos, D. Demkee, J. Dickinson, D. Everett, T. Finley, A. Gribanova, R. Hill, J. Johnson, C. Kofoed, C. Loeffler, P. Louarn, M. Maple, W. Mills, C. Pollock, M. Reno, B. Rodriguez, J. Rouzaud, D. Santos-Costa, P. Valek, S. Weidner, P. Wilson, R. J. Wilson, and D. White
- Published
- 2013
- Full Text
- View/download PDF
23. The Interstellar Boundary Explorer High Energy (IBEX-Hi) Neutral Atom Imager
- Author
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H. O. Funsten, F. Allegrini, P. Bochsler, G. Dunn, S. Ellis, D. Everett, M. J. Fagan, S. A. Fuselier, M. Granoff, M. Gruntman, A. A. Guthrie, J. Hanley, R. W. Harper, D. Heirtzler, P. Janzen, K. H. Kihara, B. King, H. Kucharek, M. P. Manzo, M. Maple, K. Mashburn, D. J. McComas, E. Moebius, J. Nolin, D. Piazza, S. Pope, D. B. Reisenfeld, B. Rodriguez, E. C. Roelof, L. Saul, S. Turco, P. Valek, S. Weidner, P. Wurz, and S. Zaffke
- Published
- 2009
- Full Text
- View/download PDF
24. Ontogenetic quinpirole treatment produces long-lasting decreases in the expression of Rgs9, but increases Rgs17 in the striatum, nucleus accumbens and frontal cortex
- Author
-
Amanda M, Maple, Marla K, Perna, Joshua P, Parlaman, Gregg D, Stanwood, and Russell W, Brown
- Subjects
Male ,Quinpirole ,Receptors, Dopamine D2 ,Dopamine ,Brain ,Corpus Striatum ,Nucleus Accumbens ,Frontal Lobe ,Rats ,Receptors, G-Protein-Coupled ,Time ,Rats, Sprague-Dawley ,Animals, Newborn ,Gene Expression Regulation ,GTP-Binding Proteins ,Dopamine Agonists ,Animals ,Female ,Yawning ,RGS Proteins - Abstract
Ontogenetic treatment of rats with the dopamine D(2)-like receptor agonist quinpirole produces a significant increase in dopamine D(2) receptor sensitivity that persists throughout the animal's lifetime, a phenomenon known as D(2) priming. The present study was designed to investigate the effects of priming of the D(2) receptor on the expression of three different members of the regulator of G-protein signaling (RGS) family: Rgs4, Rgs9 and Rgs17. Male offspring were ontogenetically treated with quinpirole or saline from postnatal days (P)1-21 and raised to adulthood. On approximately P65, animals were given an acute quinipirole injection (0.1 mg/kg) and the number of yawns was recorded for 1 h after the injection. Yawning has been shown to be a behavioural event mediated by the dopamine D(2)/D(3) receptor. Animals ontogenetically treated with quinpirole demonstrated a significant 2.5-fold increase in yawning as compared to controls. Rgs transcripts were analysed through in situ hybridization several weeks later. Rats ontogenetically treated with quinpirole demonstrated a significant decrease in Rgs9 expression in the frontal cortex, but a more robust decrease in the striatum and nucleus accumbens as compared to controls. Regarding Rgs17, ontogenetic quinpirole produced a modest but significant increase in expression in the same brain areas. There were no significant differences in Rgs4 expression produced by drug treatment in any of the brain regions analysed. This study demonstrates that ontogenetic quinpirole treatment, which results in priming of the D(2) receptor, results in significant decreases in Rgs9, which has been shown to regulate G-protein coupling to D(2) receptors.
- Published
- 2007
25. TEST: A Modular Scientific Nanosatellite
- Author
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A. Kirchoff, Art White, J. Dailey, J. Hibbs, M. Maple, J. J. Zapf, David L. Voss, D. P. Hagerman, Hank D. Voss, and Farzad Kamalabadi
- Subjects
Engineering ,Spectrometer ,business.industry ,Instrumentation ,Photometer ,Modular design ,Lightning ,law.invention ,Satellite bus ,law ,Satellite ,Very low frequency ,business ,Remote sensing - Abstract
A powerfully instrumented, reliable, low -cost, and 3 -axis stabilized nanosatellite is being developed as part of the Air Force University Nanosatellite -3 Program. The Thunderstorm Effects in Space: Technology (TEST) nanosatellite imple ments a new, highly modular satellite bus structure and common electrical interface that is conducive to satellite modeling, development, testing, and integration flow. TEST is a low -cost ($0.2 M) nanosatellite (30kg) in final development by Taylor Univer sity and the University of Illinois. TEST implements a variety of plasma, energetic particle, and remote sensing instrumentation with the objective of understanding how lightning and thunderstorms influence the upper atmosphere and the near -space environme nt. The TEST modular design and instrumentation challenges portions of satellite systems (such as future DOD DMSP and NASA LWS Geospace Missions), while complementing large multi -probe and remote sensing programs. TEST includes a variety of proven instrume ntation: two 1m Electric Field (EP) probes, a thermal plasma density Langmuir Probe (LP), a 5 to 100 kHz Very Low Frequency (VLF) Receiver, two large geometric factor cooled ( -60 ° C) Solid State Detector (SSD) spectrometers for energetic electrons and ions (10 keV< E
- Published
- 2004
- Full Text
- View/download PDF
26. Investigation of the Double Superconducting Transition and Low-Temperature Specific Heat of Pr(Os1-xRux)4Sb12.
- Author
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N. Frederick, T. Sayles, and M. Maple
- Subjects
SUPERCONDUCTORS ,LOW temperatures ,MAGNETIC fields ,SUPERCONDUCTIVITY - Abstract
The double superconducting transition in PrOs
4 Sb12 , first observed in specific heat C(T) measurements on single crystal samples, was studied by means of specific heat measurements on PrOs4 Sb12 crystals that had been subjected to applied magnetic fields, substitution of up to 4 Ru for Os, and annealing. The double superconducting transitions of a batch of single crystals were measured before and after annealing for 5 days at 500°C, to remove strains and promote homogeniety, with no observed change. Measurements of C(T) near Tc for PrOs4 Sb12 in several magnetic fields are also presented, detailing the evolution of the double transition up to 1 T. Samples of Pr(Os1-x Rux )Sb12 with 0.01 ≤ x ≤ 0.04 also appear to display a double superconducting transition in specific heat. In addition, samples with the smallest Ru concentration measured (x = 0.01) may even display a more isotropic type of superconductivity than pure PrOs4 Sb12 (x = 0). [ABSTRACT FROM AUTHOR]- Published
- 2007
- Full Text
- View/download PDF
27. Same day surgery centers: landmines or goldmines?
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M, Maple
- Subjects
Ambulatory Surgical Procedures ,Surgicenters ,Humans ,Physicians' Offices - Published
- 1987
28. Involving physicians in hospital governance
- Author
-
M, Maple
- Subjects
Governing Board ,Hospital Administration ,Attitude of Health Personnel ,Physicians ,Surveys and Questionnaires ,Texas - Published
- 1974
29. Treatment of staphylococcic infections with erythromycin
- Author
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William M. M. Kirby, Francis M. Maple, and Trygve Forland
- Subjects
Chlortetracycline ,medicine.medical_specialty ,Staphylococcus aureus ,Hospitalized patients ,medicine.drug_class ,business.industry ,Chloramphenicol ,Antibiotics ,Erythromycin ,Bacitracin ,Oxytetracycline ,Infections ,Microbiology ,Micrococcus ,Antibiotic therapy ,Internal medicine ,Internal Medicine ,medicine ,business ,medicine.drug - Abstract
FROM THE standpoint of antibiotic therapy, infections caused by staphylococci constitute one of the major problems at the present time. In hospitalized patients approximately 70% of staphylococcic infections are caused by penicillin-resistant organisms and 40 to 60% are resistant to chlortetracycline (aureomycin) and oxytetracycline. 1 In many instances, the only antibiotics available for treatment are bacitracin and chloramphenicol, both of which must be administered with caution because of possible toxic reactions. In vitro studies indicate that a new antibiotic, erythromycin, should be a highly effective agent for the therapy of staphylococcic infections. To date, only isolated case reports have appeared. 2 During the past several months we have had the opportunity of observing the effects of erythromycin therapy in 34 patients with infections caused by antibiotic-resistant staphylococci. Results of treatment were uniformly good and will be described in the present report. PLAN OF STUDY Selection of Patients. —Thirty-four patients with
- Published
- 1953
30. TREATMENT OF BACTERIAL PNEUMONIA WITH ERYTHROMYCIN
- Author
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Francis M. Maple, Wayne S. Waddington, and William M. M. Kirby
- Subjects
Gram-negative bacteria ,biology ,medicine.drug_class ,business.industry ,Gram-positive bacteria ,Antibiotics ,Bacterial pneumonia ,Erythromycin ,Pneumonia ,biology.organism_classification ,medicine.disease ,Macrolide Antibiotics ,Microbiology ,Penicillin ,Pneumonia, Bacterial ,Internal Medicine ,medicine ,Humans ,Sputum ,medicine.symptom ,business ,medicine.drug - Abstract
ERYTHROMYCIN, a derivative of Streptomyces erythreus, is effective chiefly against Gram-positive bacteria, and in this respect it resembles penicillin. 1 Perhaps the most promising attribute of this antibiotic is its effectiveness against strains of staphylococci which are penicillin-resistant. Pneumococci and streptococci are also highly sensitive to erythromycin, and blood levels which are highly effective against these organisms are readily obtained following oral administration of the drug. 2 Side-reactions are rare and consist for the most part of mild gastrointestinal disturbances. The present study was undertaken to evaluate erythromycin in the treatment of adult patients with pneumonia caused by Gram-positive bacteria. METHODS AND MATERIALS Seventy-five adult patients admitted to the infectious disease ward of King County Hospital from July, 1952, to July, 1953, with bacterial pneumonia were treated with erythromycin. The patients were predominantly in the older age groups. Many were suffering from the multiple concomitant diseases which are so common
- Published
- 1954
- Full Text
- View/download PDF
31. Investigation of the Double Superconducting Transition and Low-Temperature Specific Heat of Pr(Os1-xRux)4Sb12.
- Author
-
N. Frederick, T. Sayles, and M. Maple
- Subjects
- *
SUPERCONDUCTORS , *LOW temperatures , *MAGNETIC fields , *SUPERCONDUCTIVITY - Abstract
The double superconducting transition in PrOs4Sb12, first observed in specific heat C(T) measurements on single crystal samples, was studied by means of specific heat measurements on PrOs4Sb12crystals that had been subjected to applied magnetic fields, substitution of up to 4 Ru for Os, and annealing. The double superconducting transitions of a batch of single crystals were measured before and after annealing for 5 days at 500°C, to remove strains and promote homogeniety, with no observed change. Measurements of C(T) near Tcfor PrOs4Sb12in several magnetic fields are also presented, detailing the evolution of the double transition up to 1 T. Samples of Pr(Os1-xRux)Sb12with 0.01 ≤ x ≤ 0.04 also appear to display a double superconducting transition in specific heat. In addition, samples with the smallest Ru concentration measured (x = 0.01) may even display a more isotropic type of superconductivity than pure PrOs4Sb12(x = 0). [ABSTRACT FROM AUTHOR]
- Published
- 2007
- Full Text
- View/download PDF
32. Neuronal reorganization in adult rats neonatally exposed to (±)-3,4-methylenedioxymethamphetamine
- Author
-
Michael T. Williams, Matthew R. Skelton, Ian D. Longacre, Kimberly N. Huggins, Amanda M. Maple, Charles V. Vorhees, and Russell W. Brown
- Subjects
Development ,Golgi–Cox staining ,Dentate gyrus ,Entorhinal cortex ,Toxicology. Poisons ,RA1190-1270 - Abstract
The abuse of methylenedioxymethamphetamine (MDMA) during pregnancy is of concern. MDMA treatment of rats during a period of brain growth analogous to late human gestation leads to neurochemical and behavioral changes. MDMA from postnatal day (P)11–20 in rats produces reductions in serotonin and deficits in spatial and route-based navigation. In this experiment we examined the impact of MDMA from P11 to P20 (20 mg/kg twice daily, 8 h apart) on neuronal architecture. Golgi impregnated sections showed significant changes. In the nucleus accumbens, the dendrites were shorter with fewer spines, whereas in the dentate gyrus the dendritic length was decreased but with more spines, and for the entorhinal cortex, reductions in basilar and apical dendritic lengths in MDMA animals compared with saline animals were seen. The data show that neuronal cytoarchitectural changes are long-lasting following developmental MDMA exposure and are in regions consistent with the learning and memory deficits observed in such animals.
- Published
- 2014
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- View/download PDF
33. Effectiveness of Brief Contact Interventions for Bereavement: A Systematic Review.
- Author
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McGill K, Bhullar N, Pearce T, Batterham PJ, Wayland S, and Maple M
- Subjects
- Humans, Psychotherapy, Brief methods, Social Support, Bereavement
- Abstract
Brief contact interventions are an efficient and cost-effective way of providing support to individuals. Whether they are an effective bereavement intervention is not clear. This systematic review included articles from 2014 to 2021.711 studies were identified, with 15 meeting inclusion criteria. The brief contact interventions included informational and emotional supports. Narrative synthesis identified that participants valued brief contact interventions, however some did not find them helpful. Exposure to a brief contact intervention was typically associated with improvements in wellbeing. Studies with comparison groups typically found significant but modest improvements in grief, depression symptoms and wellbeing associated with the intervention. However, one intervention was associated with significant deterioration of depression symptoms. Existing brief contact interventions for bereavement appear feasible, generally acceptable to the target population and are associated with improvements in wellbeing. Further development and evaluation to account for why improvements occur, and to identify any unintended impacts, is required., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
- Published
- 2024
- Full Text
- View/download PDF
34. Measuring the outcomes of support provided to people after a suicide or other sudden bereavement: A scoping review.
- Author
-
Jackson B, Wayland S, Ball SA, Lamperd A, Potter A, and Maple M
- Abstract
Systematic collection of outcome measures within suicide bereavement support is vital in building the sector's evidence base. However, there is currently limited understanding around the appropriate and sensitive use of outcome measures. Following the scoping review methodology, a literature review was undertaken to map how programs and interventions that assist individuals bereaved by suicide or other sudden, traumatic deaths gather outcome measures. The search strategy identified 1145 papers, of which 49 met the inclusion criteria. The review identified many ways that outcomes are captured, with custom tools being commonplace. Among standardized tools, the Grief Experience Questionnaire (GEQ) and Beck Depression Inventory (BDI-II) emerged as frequently used. Most articles provided some form of justification for their chosen outcome measure methodology, often citing psychometric robustness over consideration of the impact on service users. The review underscores the need for careful consideration when selecting outcome measure tools or approaches in sudden death bereavement interventions.
- Published
- 2024
- Full Text
- View/download PDF
35. The impact of relationship type and closeness on mental health following suicide loss.
- Author
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Brown HL, Selbe SM, Flesaker M, Rosellini AJ, Maple M, Gradus JL, and Cerel J
- Subjects
- Humans, Male, Female, Adult, Middle Aged, Mental Health, Depression psychology, Bereavement, Family psychology, Interpersonal Relations, Aged, Anxiety psychology, Adolescent, Young Adult, Friends psychology, Stress Disorders, Post-Traumatic psychology, Grief, Suicide psychology
- Abstract
Background: Most research investigating the effect of suicide on loss survivors has been limited to first-degree family members. Few studies examine the impact of suicide on others outside the immediate family and the influence of relationship type and closeness on mental health., Methods: This study used data from a sample obtained through random digit dialing (n = 805) to assess exposure to suicide loss, relationship types, perceived closeness, and mental health symptoms (prolonged grief, depression, anxiety, and posttraumatic stress disorder)., Results: Familial status, friend status, and higher perceived closeness were associated with prolonged grief, depression, and posttraumatic stress disorder, with the strongest adjusted associations observed for posttraumatic stress disorder and prolonged grief. In general, the magnitude of adjusted standardized associations for closeness and mental health symptoms was stronger than those observed for familial status and mental health symptoms and friend status and mental health symptoms., Conclusion: Closeness, familial status, and friend status are associated with mental health symptoms experienced after suicide loss, but the magnitude of associations was strongest for closeness. Future studies should examine perceived closeness in addition to other factors related to relationship type and dynamics to assess the complexities of suicide bereavement reactions., (© 2024 American Association of Suicidology.)
- Published
- 2024
- Full Text
- View/download PDF
36. Effectiveness and Acceptability of Interventions Offered for Those Bereaved by Parental Loss to Suicide in Childhood: A Mixed Methods Systematic Review.
- Author
-
Graham F, Bartik W, Wayland S, and Maple M
- Abstract
Objectives: Identify interventions offered for children bereaved by parental suicide, investigate reported effectiveness and explore the acceptability of identified interventions., Method: Six electronic databases were systematically searched for primary studies investigating intervention effectiveness and acceptability, (August 2011 to June 2023). Eligibility required inclusion of participants bereaved by parental suicide during childhood among sample populations. Methodological quality was evaluated applying JBI critical appraisal tools. Narrative synthesis was conducted using parallel-results convergent design., Results: Of the 22 eligible reports, 19 articles reported on 12 manual-based supports provided during childhood; three papers described users' experiences of various specified intervention types offered following childhood loss. Twenty-one studies reported on interventions offered for heterogeneous participant groups that included children bereaved by parental suicide. Time from loss to intervention generally included both recent (1 < 30mths) and more distant loss, with just one intervention described as solely for recently bereaved children. Eight interventions ( n = 12 studies) demonstrated significant positive effects (p < 0.05), for maladaptive grief, mental health, quality of life. Only one study investigated suicide-related outcomes. Qualitative findings (n = 8 studies) facilitated development of four acceptability themes: Perceived utility, Relationships, Components and Delivery., Conclusions: Heterogeneity in causes of loss/trauma and relationships with the deceased limit specific conclusions regarding effectiveness/acceptability of reviewed interventions for children bereaved by parental suicide. Few sub-group analyses of effects were reported, and qualitative evidence specifically from children bereaved by parental suicide was limited. Further research is recommended regarding mixed-user interventions, specifically for children bereaved by parental suicide.
- Published
- 2024
- Full Text
- View/download PDF
37. Operationalizing the Consolidated Framework for Implementation Research to build and support the lived experience workforce in direct health service provision.
- Author
-
Carrandi A, Hu Y, McGill K, Wayland S, Karger S, and Maple M
- Subjects
- Humans, Implementation Science, Delivery of Health Care, Integrated organization & administration
- Abstract
Background: The involvement of people with lived experience (LEX) workers in the development, design, and delivery of integrated health services seeks to improve service user engagement and health outcomes and reduce healthcare gaps. Yet, LEX workers report feeling undervalued and having limited influence on service delivery. There is a need for systematic improvements in how LEX workforces are engaged and supported to ensure the LEX workforce can fully contribute to integrated systems of care., Objective: This study aimed to operationalize the Consolidated Framework for Implementation Research (CFIR) using a rigorous scoping review methodology and co-creation process, so it could be used by health services seeking to build and strengthen their LEX workforce., Search Strategy: A systematic literature search of four databases was undertaken to identify peer-reviewed studies published between 2016 and 2022 providing evidence of the inclusion of LEX workers in direct health service provision., Data Extraction and Synthesis: A descriptive-analytical method was used to map current evidence of LEX workers onto the CFIR. Then, co-creation sessions with LEX workers (n = 4) and their counterparts-nonpeer workers (n = 2)-further clarified the structural policies and strategies that allow people with LEX to actively participate in the provision and enhancement of integrated health service delivery., Main Results: Essential components underpinning the successful integration of LEX roles included: the capacity to engage in a co-creation process with individuals with LEX before the implementation of the role or intervention; and enhanced representation of LEX across organizational structures., Discussion and Conclusion: The adapted CFIR for LEX workers (CFIR-LEX) that was developed as a result of this work clarifies contextual components that support the successful integration of LEX roles into the development, design, and delivery of integrated health services. Further work must be done to operationalize the framework in a local context and to better understand the ongoing application of the framework in a health setting., Patient or Public Contribution: People with LEX were involved in the operationalization of the CFIR, including contributing their expertise to the domain adaptations that were relevant to the LEX workforce., (© 2024 The Authors. Health Expectations published by John Wiley & Sons Ltd.)
- Published
- 2024
- Full Text
- View/download PDF
38. Understanding solastalgia from a decolonised, Indigenist lens: a scoping review.
- Author
-
Upward K, Usher K, Saunders V, and Maple M
- Subjects
- Australia, Indigenous Peoples, Climate Change, Australian Aboriginal and Torres Strait Islander Peoples psychology
- Abstract
The objective of this review is to use a decolonised, Indigenist lens to understand the definition of solastalgia from an Aboriginal perspective, as a potential emotional response experienced by Aboriginal communities impacted by increasingly frequent natural disasters, such as bushfires. Initial search results revealed a lack of literature referencing solastalgia in an Aboriginal-specific context. Indigenist research methodologies such as Heuristic inquiry and Aboriginal Participatory Action Research (APAR) contributed to the identification of alternative terminologies, which led to the majority of the included publications referring to solastalgia-related concepts, with one included publication mentioning solastalgia specifically. These methods were consequently used to synthesize data, confirm results and contribute to final discussions. Lastly, our results determined that at this stage there is insufficient evidence to conclusively suggest that Aboriginal Peoples in a general sense, experience solastalgia. Acknowledging the ethical dilemma and potential harm of generalising personal philosophies and experiences based on Culture. Thereby, signify the need for further research in this space and in particular, from a decolonised, Indigenist perspective., Preface: In the context of this review, we as co-authors are mindful of and respect the tensions or politics associated with proclaiming or discussing the identities of Australia's First Peoples. Therefore, in the context of this review, the often preferred term Aboriginal refers to the traditional owners of Australia. Where possible, traditional place/tribe names are written to acknowledge the ownership and origins of the information referenced within this review. Furthermore, we wish to acknowledge the storeys and traditional knowledge shared by the authors of the studies referenced within this review. These words of Country and Kin have contributed to the development and conceptualisation of this literature review, and we wish to pay our respects and appreciation., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Upward, Usher, Saunders and Maple.)
- Published
- 2024
- Full Text
- View/download PDF
39. Impacts of exposure to suicide of a military colleague from the lived experience of veterans: Informing postvention responses from a military cultural perspective.
- Author
-
Jamieson SK, Cerel J, and Maple M
- Subjects
- Humans, Male, Female, Adult, Middle Aged, United States, Qualitative Research, Veterans psychology, Suicide psychology, Military Personnel psychology
- Abstract
Although exposure to the suicide death of a military colleague has been shown quantitatively to increase suicide risk factors among veterans, there are very few studies where veterans have been asked about this experience. This article presents a qualitative analysis of 38 interviews with U.S. veterans with exposure to the suicide death of a military colleague in past war operations. Participants described the impact of exposure in relation to the military context and official response to the death, which had long-term ramifications. Our findings suggest suicide prevention and postvention responses for veterans should be informed by the lived experience of veterans, including those for whom this experience occurred significantly in the past, as the impacts of different military policies and practices in response to suicide deaths over time are relevant to the impact of exposure to death of a military colleague in the short and long term.
- Published
- 2024
- Full Text
- View/download PDF
40. Examining the Association Between Moral Injury and Suicidal Behavior in Military Populations: A Systematic Review.
- Author
-
Jamieson N, Carey LB, Jamieson A, and Maple M
- Subjects
- Humans, Male, Adult, Suicidal Ideation, Suicide, Attempted psychology, Risk Factors, Military Personnel psychology, Stress Disorders, Post-Traumatic epidemiology, Stress Disorders, Post-Traumatic psychology, Veterans psychology
- Abstract
The increasing number of suicides among military populations cannot be fully accounted for by conventional risk factors like Post-Traumatic Stress Disorder (PTSD). As a result, researchers and theorists propose that delving into the concept of Moral Injury could offer a more comprehensive understanding of the phenomenon of suicide. Moral Injury is not currently a recognized mental health disorder but can be associated with PTSD. Moral Injury is a multi-dimensional issue that profoundly affects emotional, psychological, behavioral, social, and spiritual well-being. The objective of this systematic review is to examine the association between Moral Injury and suicidal behavior (suicide ideation, plans and or suicide attempt) within military populations. The review will specifically concentrate on identifying and analyzing studies that have investigated the connection between these variables, with a specific focus on the context of military personnel both serving and former serving members. Of the 2214 articles identified as part of this review, 12 studies satisfied the research criteria with a total participant sample having an average age of 40.7 years. The male population accounted for 78.6% of the overall sample. Two studies were identified as high-quality, while the remaining ten were rated as moderate. The analysis of these twelve studies consistently affirms a connection between Moral Injury and suicidal behavior; most obviously, that exposure to morally injurious events substantially amplify the risk of suicide, with higher levels of potential exposure being linked to increased Moral Injury and heightened levels of suicidal behavior. Our review uncovered noteworthy findings regarding the association between Moral Injury and suicidal behavior, marking a pioneering effort in exploring this association and offering valuable insights into this emerging issue. Several limitations are noted regarding this review and recommendations are made concerning the need to prioritize, expand and employ longitudinal research designs that include non-military populations such as first responders (e.g., police, paramedics, firefighters) and medical, nursing, or allied health professionals-all disciplines known to be impacted by Moral Injury., (© 2023. Crown.)
- Published
- 2023
- Full Text
- View/download PDF
41. School-based multidisciplinary student-led clinics in health and Australian accreditation standards: A scoping review.
- Author
-
Maple M, O'Neill K, Gartshore S, Clark J, White J, and Pearce T
- Subjects
- Child, Humans, Adolescent, Australia, Health Personnel education, Learning, Health Promotion, Students
- Abstract
Introduction: Student-led clinics can provide health services to marginalised groups where service offerings are sparse or difficult to access, such as rural areas. Offering these services to children and young people can promote health and well-being by addressing the individual challenges and the social determinants of health. There is uncertainty, however, as to whether student-led clinics can meet Australian accreditation standards for health professionals completing degree programs., Objective: This study aims to determine the capacity for health student placements in school-based student-led clinics to meet accreditation standards., Design: A systematic scoping review was conducted based on Arksey and O'Malley's framework and the PRISMA-ScR statement., Setting: Several databases were examined, including Ebsco (Academic Source and CINAHL), ProQuest (PsycINFO, ERIC) and grey literature sources along with a desktop review of accreditation standards across seven health disciplines. Two independent reviewers screened eligible studies., Findings: The search retrieved 1037 records with 65 full-text papers assessed for eligibility. Eleven papers met the inclusion criteria. Based on the evidence, both nursing and exercise and sports science accreditation standards were best suited to student-led clinics., Discussion: Although broad categories of work-integrated learning activities were applied, it appears feasible to expect accreditation standards for health disciplines at an Australian university to be a good fit for health student-led school-based clinics., Conclusion: Increasing health student placement opportunities within student-led clinics can improve the health and well-being of children and young people in regional, rural and remote (RRR) areas of Australia who may otherwise have limited access to allied health services., (© 2023 The Authors. Australian Journal of Rural Health published by John Wiley & Sons Australia, Ltd on behalf of National Rural Health Alliance Ltd.)
- Published
- 2023
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42. Prevalence and risk factors of physical and psychological health among readymade garment workers in Bangladesh.
- Author
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Kabir H, Bhullar N, Islam MS, Usher K, Haque ME, and Maple M
- Subjects
- Adult, Male, Humans, Female, Bangladesh epidemiology, Prevalence, Cross-Sectional Studies, Risk Factors, Clothing
- Abstract
Objective . Poor health outcomes of Bangladeshi readymade garment (RMG) workers tend to be associated with a variety of occupational factors. This study aimed to investigate the prevalence of, and risk factors associated with, the physical and psychological health outcomes of Bangladeshi RMG workers. Methods . Responses to a cross-sectional survey from a convenience sample of 411 adult Bangladeshi RMG workers (mean age = 26.24 years; SD 6.40 years; female = 80%) were analysed using bivariate and multivariate (logistic regression models) analyses. Results . More than half of the participants reported headaches (61.6%) and colds/flu (51.3%), followed by fever (37.2%), diarrhoea (32.8%), bodily pain (29.9%) and respiratory infections (20.9%). For psychological health, stress (69.1%), anxiety (66.2%) and boredom (64.5%) were most prevalent, followed by sleeplessness (51.3%), depression (48.2%) and fear (34.3%). RMG workers from the factories located in Chattogram (a peripheral region compared to Dhaka) reported poorer physical and psychological health outcomes than those working in factories in Dhaka (the capital city of Bangladesh). Overall, compared to males, female RMG workers were more likely to be vulnerable to both physical and psychological health outcomes. Conclusion . Improvement in workplace conditions and safety programmes is needed to safeguard the overall health outcomes of Bangladeshi RMG workers.
- Published
- 2023
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43. Unpacking the Meaning of Closeness, Reconsidering the Concept of Impact in Suicide Exposure, and Expanding Beyond Bereavement: "Just, I Hope You Don't Forget About Us".
- Author
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Sanford RL, Frey LM, Thind N, Butcher B, and Maple M
- Abstract
Suicide exposure research has relied on samples of treatment-seeking kin, resulting in an attachment-based model centering bereavement as the most significant form of impact and obscuring other forms of significant and life-altering impact. From a community-based sample ( N = 3010) exposed to suicide, we examine a subset ( n = 104) with perceived high impact from the death yet low reported closeness to the person who died and analyze qualitative comments ( n = 50). On average and out of 5.00, participants rated closeness as 1.56 but impact of death as 4.51. We illustrate dimensions of low closeness and identify themes on the meaning of impact: impact through society and systemic circumstances, impact through history and repeated exposure, impact through other people, impact as a motivator for reflection or change, and impact through shared resonance. Participants reported impact of death as significant or devastating, yet none of their comments reflected experiences typical of bereavement., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: At the time of the study, M.M. was a member elected Director on the Board of Suicide Prevention Australia.
- Published
- 2023
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44. Qualitative research in suicidology: a systematic review of the literature of low-and middle-income countries.
- Author
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Kabir H, Wayland S, and Maple M
- Subjects
- Humans, Qualitative Research, Developing Countries, Suicide
- Abstract
Background: Suicide is more prevalent among disadvantaged, discriminated, and marginalised people with the majority of global suicide deaths occurring in the low-and middle-income countries (LMICs). This can be attributed to sociocultural contexts and exacerbated by access to limited resources and services that can assist with early identification, treatment, and support. Accurate information on the personal experiences of suicide is lacking, as many LMICs legislate that suicide is illegal., Methods: This study aims to review the qualitative literature to explore the experiences of suicide in LMICs from the first-person perspective. Following the PRISMA-2020 guidelines, the search for qualitative literature published between January 2010 and December 2021 was undertaken. A total number of 110 qualitative articles from 2569 primary studies met the inclusion criteria. Included records were appraised, extracted, and synthesised., Results: The results provide lived experience insight into suicide from those living in LMICs, including understanding variations of the causes of suicides, the impacts on others exposed to suicide, existing support systems, and prevention measures to reduce suicide among LMICs. The study offers a contemporaryunderstanding of how people in LMIC experience suicide., Conclusions: The findings and recommendations are derived from the similarities and differences within the existing knowledge base that is dominated by evidence from high-income countries. Timely suggestions for future researchers, stakeholders, and policymakers are provided., (© 2023. The Author(s).)
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- 2023
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45. Predictors of Caregiver Burden Among Carers of Suicide Attempt Survivors.
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Maple M, Wayland S, Sanford RL, and Bhullar N
- Subjects
- Humans, Female, Male, Caregiver Burden, Cross-Sectional Studies, Survivors, Caregivers psychology, Suicide, Attempted
- Abstract
Background: Family members often provide informal care following a suicide attempt. Carers may be vulnerable to caregiver burden. Yet, little is known about what contributes to this. Aims: To determine the predictors of caregiver burden in those carers who support people who have attempted suicide. Method: An online survey of 435 participants assessed exposure to suicide, caring behaviors, and psychological variables and caregiver burden. Results: A multivariate model explained 52% of variance in caregiver burden. Being female, closeness to the person, impact of suicide attempt, frequency of contact pre-attempt, and psychological distress were positively associated with caregiver burden. Confidence in supporting the person after suicide attempt, perceived adequacy of healthcare the person received and the support the carer received, and suicidal ideation of the carer were negatively associated with caregiver burden. Moderation analysis suggested that carers with high levels of distress reported negative association between suicidal ideation and caregiver burden. Limitations: The cross-sectional online survey design of self-identified carers is a limitation of the study. Conclusion: Carers are highly distressed, and if unsupported report increased suicide ideation. In their caring roles they may have contact with support services, thus attending to their needs may ameliorate caregiver burden and associated negative outcomes.
- Published
- 2023
- Full Text
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46. Key issues, challenges, and preferred supports for those bereaved by suicide: Insights from postvention experts.
- Author
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McGill K, Bhullar N, Batterham PJ, Carrandi A, Wayland S, and Maple M
- Subjects
- Humans, Grief, Surveys and Questionnaires, Bereavement, Suicide
- Abstract
For many, suicide bereavement is challenging. Postvention responses are few and evidence to inform them is lacking. Eighteen postvention experts completed an online survey regarding the key issues, challenges, and supports available to people bereaved by suicide. Participants were asked to identify the issues, then rank them in terms of importance at key times during the first 2 years after death, with navigating grief, managing relationships, and dealing with practical challenges identified. Access to information, practical assistance and non-judgmental support were most important early in the bereavement period. These findings provide a foundation for recommendations for postvention interventions.
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- 2023
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47. Co-creation of new knowledge: Good fortune or good management?
- Author
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Pearce T, Maple M, McKay K, Shakeshaft A, and Wayland S
- Abstract
Background: Potential solutions to bridging the research practice gap include collaborative frameworks and models. Yet there is little evidence demonstrating their application in practice. In addressing this knowledge gap, this in-depth case study explored how the co-creation of new knowledge framework and its four collaborative processes (co-ideation, co-design, co-implementation, and co-evaluation) are utilised to support people who had attempted suicide through an Australian psychoeducational program known as Eclipse., Methods: Using a case study design and a thematic analysis methodology, multiple sources of qualitative data (collaborative group discussion, personal communications) were analysed inductively and deductively to examine the implementation of co-creation and explore the perspectives of researchers and stakeholders about co-creation and collaborative relationships., Results: Three broad themes were identified: (1) understanding the language and practice of co-creation, (2) perception of trust formation, and (3) the value of co-creation opportunities. Ultimately, implementing co-creation with or between researchers, industry and people with lived experience requires trust, reciprocity, good fortune, and good management. While implementing co-creation, the co-creation framework was revised to include additional elements identified as missing from the initially proposed framework., Conclusion: Co-creation of new knowledge poses many challenges to researchers and stakeholders, particularly regarding its "messiness" and non-linear approach to implementation and evaluation. However, as this case study demonstrates, it has the potential to become an alternative framework of best practice for public health interventions in third sector organisations, most notably as it eliminates the often-lengthy gap reported between research evidence and translation into practice. The research highlights the need for co-creation to further study its effectiveness in integrating research and service delivery to generate new knowledge. This may lead to a cultural and behavioural change in the service provider's approach to research, offering better outcomes for providers, clients, policymakers, universities, and funders., (© 2022. The Author(s).)
- Published
- 2022
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48. A Psychoeducational Support Group Intervention for People Who Have Attempted Suicide: An Open Trial with Promising Preliminary Findings.
- Author
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Maple M, Wayland S, Pearce T, Sanford R, and Bhullar N
- Subjects
- Humans, Risk Factors, Suicidal Ideation, Self-Help Groups, Suicide, Attempted prevention & control
- Abstract
Psychoeducational groups have been used to address many health needs. Yet, there are few such options available for people who have attempted suicide. This study presents preliminary findings from an open trial of Eclipse, an 8-week closed, psychoeducational group for people who have attempted suicide. It examined the effectiveness of the Eclipse program in reducing suicidal ideation, depressive symptoms, perceived burdensomeness and thwarted belongingness, and increasing resilience and help-seeking. Results showed statistically significant improvements in depressive symptoms, perceived burdensomeness, resilience and help-seeking from baseline (T1) to immediate post-test (T2), and in perceived burdensomeness from T1 to 1-month follow-up (T3). A pervasiveness analysis showed that over half of the participants reported improvements in key study outcomes, respectively, as a result of participating in the Eclipse group. Psychoeducational support groups could provide broad application for those who have previously attempted suicide in decreasing severity of suicidal thinking by reductions in depressive symptoms, burdensomeness, and thwarted belongingness., (© 2022. The Author(s).)
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- 2022
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49. Evidence of co-creation practices in suicide prevention in government policy: a directed and summative content analysis.
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Pearce T, Maple M, Wayland S, McKay K, Shakeshaft A, and Woodward A
- Subjects
- Australia, Government, Humans, Health Policy, Suicide Prevention
- Abstract
Background: In Australia, the collaborative involvement of stakeholders, especially those with lived experience in mental health and suicide prevention, has become important to government policy and practice at Federal and State levels. However, little is known about how governments translate this intention into frameworks of co-creation for policy, funding programs, service improvement, and research and evaluation. We investigated the extent to which publicly available government policies refer to collaborative practice using an established translation model., Methods: An exploratory directed and summative content analysis approach was used to analyse the contents of Federal (also known as Commonwealth), State and Territories policy documents on mental health and suicide prevention published in Australia between 2010 and 2021. The data was extracted, compared to an existing translation model, and summated to demonstrate the evidence of co-creation-related concepts between government and stakeholders., Results: 40 policy documents (nine at the Federal and 31 at the State and Territory level) were identified and included in the analysis. Only 63% of policy documents contained references to the concept of co-design. Six of the State policies contained references to the concept of co-production. Across all policy documents, there were no references to other concepts in the model adopted for this study, such as co-creation, co-ideation, co-implementation, and co-evaluation., Conclusion: Although the government at Federal, State and Territory levels appear to support collaborative practice through partnership and co-design, this study suggests a narrow approach to the theoretical model for co-creation at a policy level. Implications for both research and practice are discussed., (© 2022. The Author(s).)
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- 2022
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50. Suicide exposure experience screener for use in therapeutic settings: A validation report.
- Author
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Maple M, Cerel J, Sanford R, Shand F, Batterham PJ, and Bhullar N
- Subjects
- Humans, Cross-Sectional Studies, Grief, Surveys and Questionnaires, Suicide psychology, Bereavement, Suicide Prevention
- Abstract
Introduction: A brief screener assessing experience of exposure to suicide for use in therapeutic settings is warranted. To examine the concurrent validity of such a screening tool, labeled as the Suicide Exposure Experience Screener (SEES), the associations of the two SEES items: (i) reported closeness with the person who died by suicide and (ii) perceived impact of suicide death with psychological distress are presented., Methods: Five separate datasets comprising surveys from Australia, Canada, and the United States (N
combined = 7782) were used to provide evidence of concurrent validity of closeness and impact of suicide exposure., Results: Overall, closeness and impact were significantly correlated with measures of global distress across five different datasets, showing small to medium effect sizes. Closeness and impact were also intercorrelated demonstrating a large effect size across all surveys. This report used cross-sectional data and comprised varied sample sizes across different datasets that influenced statistical significance of obtained effects and did not tease apart the roles of cumulative exposure of suicide and prolonged bereavement in experiencing global distress., Conclusion: The SEES has clinical utility in determining psychological distress in bereaved individuals and is recommended for use in therapeutic settings., (© 2022 The Authors. Suicide and Life-Threatening Behavior published by Wiley Periodicals LLC on behalf of American Association of Suicidology.)- Published
- 2022
- Full Text
- View/download PDF
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