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报告1例以分泌性中耳炎为首发表现的抗中性粒细胞胞质抗体（anti-neutrophil cytoplasmic antibodies，ANCA）相关肥厚性硬脑膜炎患者的诊断和治疗经过。患者青年女性，分泌性中耳炎后1个月出现头痛，头强化核磁提示弥漫性肥厚性硬脑膜炎，考虑免疫系统疾病，抗核抗体阴性、核周型抗中性粒细胞胞质抗体（P-ANCA）升高、脑脊液免疫球蛋白G升高，给予激素及环磷酰胺治疗有效，但在激素减量过程中出现病情反复，故给予生物制剂利妥昔单抗治疗，患者病情控制稳定。以分泌性中耳炎为首发表现的ANCA相关肥厚性硬脑膜炎病例临床少见，目前尚缺乏治疗指南或专家共识，在临床工作中，中耳炎后头痛的病例往往会首先想到颅内感染，从而忽略免疫系统疾病，故特此报道该病例以引起耳鼻喉科医师的关注。.

The honeycomb sandwich structure reflector panel is a multilayer structure formed by three-layer aluminum plate and two-layer honeycomb bonded by epoxy resin adhesive, and its thermal deformation behavior is complicated. In this study, the thermal deformation behavior of the reflector panel is studied by a combination of experiment and finite element simulation. Firstly, the thermal deformation analysis finite element model of reflector panels with honeycomb sandwich structure is established. The three-layer aluminum plate is modeled according to actual geometric parameters and adopts shell element model. The honeycomb core is equivalent to a homogeneous orthotropic layer with a constant thickness. The elastic modulus of the equivalent model of the honeycomb core with adhesive are obtained through the tensile and compressive mechanical performance tests. Then, the temperature deformation experiment of the honeycomb sandwich structure panel is carried out. Combined with the experimental results and the thermal deformation simulation analysis model, the multi-island genetic algorithm is used to modify the thermal expansion coefficient of the honeycomb core layer. Finally, the thermal deformation behavior of the reflector is verified by finite element simulation and experiment. The results show that the profile error distribution caused by the panel thermal deformation has continuous symmetry. From the error distribution trend and numerical deviation, the established simulation model can be used to predict the thermal deformation of sandwich panels.

We investigated the physical properties of ZrCuSiAs-type oxypnictide CeCrAsO polycrystals by electrical transport, magnetic and thermodynamic measurements below room temperature. No superconductivity is found down to the lowest temperature measured (1.8 K). A first-order magnetic transition is consistently observed at . A Schottky anomaly is observed around 14 K and the ground-state doublet of Ce ions splits by 3.75 meV. It is suggested that the magnetic moments of Cr ions, which show long-range order above room temperature, reorient at . Meanwhile the generated internal magnetic field induces a short-range antiferromagnetic order of Ce moments, serving as a good probe for demonstrating the interplay between Cr-3 d and Ce-4 f electrons and further investigating the magnetism of Cr ions.

In this paper, a kind of multi-functional polylactic acid-based membrane with adjustable aggregate thickness and properties was prepared. When the number of assembled layers was 20 bilayers, the mean thickness of every bilayer was found to be 10.75±0.25 nm, and the tensile strength was increased by 20% compared with the polylactic acid (PLA) films. The assembled layered double hydroxides (LDHs) could serve as a type of promising organic-inorganic luminescent material, and endow PLA with photoluminescent properties. Besides, the photoluminescence of the composite films was discovered to be highly tunable by simply adjusting the structural constituents of LDHs, and the fluorescence intensity was uniformly enhanced as the number of assembled layers increases, which was not eliminated by the isolation due to cellulose nanocrystals (CNCs). Moreover, the composite films exhibited excellent fluorescence stability in comparison with the literature. After being repeatedly bleached 1000 times by confocal laser scanning fluorescence microscope, the fluorescence intensity of the PLA/(CNCs/Mg-Al-Eu LDHs)10 film remained 96%. It could be concluded that the immobilization of CNCs and LDHs realized the microscopic controllability of the optical functional molecular spacing. With satisfactory fluorescence, the resulting PLA-based membranes exhibited considerable application potential in optoelectronic devices and anti-counterfeiting packaging.

报告一例以听力下降为首发症状的隐球菌脑膜炎患者的诊断和治疗经过，42岁男性患者，病程中出现发热、头痛，测听示双耳对称性感音神经性听力损失。头颅增强MRI示面听神经、硬脑膜强化；脑脊液培养示隐球菌，脑脊液墨汁染色阳性、隐球菌荚膜抗原阳性；肺部病变组织六胺银染色阳性。确诊为隐球菌脑膜炎、隐球菌肺炎。给予两性霉素B及氟胞嘧啶治疗后症状明显好转，听力逐渐恢复。以听力下降为首发临床表现的隐球菌脑膜炎病例少见，特此报道以引起临床医师关注，尤其是无隐球菌感染危险因素的脑膜炎患者，也应常规筛查隐球菌，避免漏诊。.

本文报道了山东大学附属山东省耳鼻喉医院耳内科诊治的1例突发性聋伴黑棘皮病及格林-巴利综合征的患者。患者中年男性，主诉突发右耳听力下降46 d，入院后进行既往病史收集、系统查体、听力学和前庭功能评估、实验室检查及影像学检查，给予改善内耳微循环、激素和降纤酶等药物治疗和前庭康复训练，治疗12 d，预后差。.

患儿 女，2岁7月龄，因"反应迟、竖头不稳"就诊。临床表现为全面性发育迟缓、肌张力障碍、肌张力增高、小头畸形、斜视、生长障碍、身材矮小、语言障碍、吞咽障碍、频繁呕吐、过度哭闹等。患儿全外显子测序结果显示细胞色素b5还原酶3基因的纯合移码变异，诊断为先天性高铁血红蛋白血症Ⅱ型，该病临床罕见。.

To uncover the role of microRNA-127-5p (miRNA-127-5p) in aggravating motor dysfunction following spinal cord injury (SCI) by regulating the mitogen-activated protein kinase 1 (MAPK1) level.In vivo SCI model in mice was established by constructing spinal cord hitting injury. Mice were classified into sham group, SCI group, SCI+miRNA-127-5p mimics group, and SCI+miRNA-127-5p mimics+MAPK1 group, respectively. Grip strengths of mouse pair forepaws, right forepaw, and left forepaw at different time points were determined. Expression levels of miRNA-127-5p and MAPK1 in mice of each group at post-SCI were detected. Potential binding sites in promoter regions of miRNA-127-5p and MAPK1 were predicted by bioinformatics and further confirmed by Dual-Luciferase reporter gene assay and Western blot.Grip strengths of SCI mice were much lower than those in sham group at different time points after SCI procedures. MiRNA-127-5p was markedly downregulated on the postoperative 3rd day in SCI group, and its level time-dependently decreased since after. In vivo overexpression of miRNA-127-5p in SCI mice improved their grip strengths from the postoperative 7th day. MAPK1 was the direct target of miRNA-127-5p. Transfection of miRNA-127-5p mimics downregulated protein level of MAPK1 in 293T cells. Overexpression of MAPK1 abolished the protective effect of miRNA-127-5p on motor function recovery following SCI.Downregulation of miRNA-127-5p aggravates SCI-induced motor dysfunction through negatively regulating MAPK1 level.

Characterization and gene cloning of acetylecholinesterase (AChE) in the insecticide-resistant (R) and -susceptible (S) insects have been reported in the past. However, the studies focused mostly on herbivorous pests, rather than predacious species, such as ladybird beetles. Using R and S Propylaea japonica (thunberg), a full-length cDNA sequence (2928 bp) of the ace1-type AChE gene was determined for the first time. The ace1 encoding a protein of 645 amino acids contained typical conserved motifs, such as FGESAG domains, catalytic triad, acyl pocket, oxyanino hole, choline binding site, peripheral anionic site, omega loop and conserved aromatic residues. R P. japonica displayed 50-times greater resistance to chlorpyrifos or mathamidophos with a significantly lower AChE sensitivity to paraoxon, malaoxon, chlorpyrifos or methamidophos than its S counterpart. Five amino acids in the ace1 of R P. japonica differed from those found in S P. japonica. One of them, F358S, located in the acyl-binding pocket, might play a crucial role in the resistance of the insect to organophosphates (OPs). Whereas, K493E and I538V, which were close to some of the conserved aromatic amino acids (i.e., H509, Y511, and W499) in the gorge, and G571R and T576A near C593 that formed the disulfide bonds with C471, might also involve in the change of insecticide resistance in P. japonica. AChE insensitivity and amino acid replacements, particularly F358S, might be the determining factors in the alteration of OPs-resistance in P. japonica.

Saline-sodic stress is a major abiotic constraint responsiblefor rice (Oryza sativa L.) yield reductions in Northeast China.The rice root system is crucial for yield development, and it is usuallyrecognized as the key for improving future crop productivity. However,most of the saline-sodic soils in these areas contain high levelsof soluble Na2CO3 and NaHCO3, which results in a high pH (>8.5),clay dispersion, soil swelling, and overall poor soil physical properties.Isolation, washing and measurement of the rice crown roots is highlytime-demanding in this kind of soil. Our aim was to explore whetherdifferences in shoot characters could be reliable indicators, and a lowcost and easy method for estimating crown root numbers in rice. Inthis study, 97 randomly selected field-grown rice hill plants, with728 stem samples, of three genotypes at the heading stage were usedin saline-sodic soils. Results gave a reliable estimation of values forcrown root numbers as indicated by high positive correlations withnumber of stems (0.788***) and tillers (0.801***); diameter of long(0.545***), short (0.555***), and mean stems (0.586**), and hill (i.e.,equal to 5 plants) circumference (0.796***) and mean hill diameter(0.366***) (P

Electromagnetic functional ceramics added iron tailings were prepared using the burning method, and the EMWA properties were tested through the arch testing method at 2–18 GHz. It was found that the minimum reflection loss (RL) peak was −16.0 dB at 17.0 GHz, and that the thickness of ceramics was 2.00 cm. With the thickness increasing, the RL value went up, and the RL peak number also increased. The magnetic and dielectric losses of tailing powders acting as an absorbent were the main mechanisms of EMWA properties for ceramics, which could be used for electromagnetic radiation protection of architectural spaces.

SUMMARYSaline-sodic soils are widely distributed in the western Songnen Plain of Northeast China and planting rice has been found to be an effective and feasible approach for improving saline-sodic soil and increasing food production. Assessment of the effectiveness and sustainability of this method requires monitoring of the changes in soil salinity and nutrient content. The objective of the current study was to investigate the changes of soil salinity and nitrogen (N) contents over 1, 3, 6 and 9 years of cultivation, four application rates of N (N0: no N, N1: 100 kg N/ha, N2: 200 kg N/ha and N3: 300 kg N/ha) and two irrigation water types: ground water irrigation (GWI) and river water irrigation (RWI). Salinity and N contents of soil and water samples were analysed before planting and after harvest throughout the experiments. Soil pH and electrical conductivity (EC), especially in the surface layer of 0–40 cm depth, decreased with years of cultivation with both GWI and RWI, while soil inorganic N and total N contents increased. Moreover, with increasing N application rates, soil inorganic N and total N contents increased significantly in the 0–20 cm soil layer. Increasing N application had little effect on soil pH and EC. Reclaiming and planting rice promoted desalination of the surface and formation of a fertile tillage layer in saline-sodic paddy fields. In terms of irrigation and drainage in saline-sodic paddy fields, both soil salinity and N contents increased. Soil total salinity increased annually by 34 and 12·8 kg/ha, and inorganic N contents increased annually by 9 and 13·5 kg/ha with GWI and RWI, respectively. Therefore, comprehensive agricultural practices should be adopted for improving and cropping rice in saline-sodic paddy fields.

Background A meta-analysis of randomized controlled trials (RCTs) was conducted to compare the effects of right ventricular nonapical (RVNA) and right ventricular apical (RVA) pacing on cardiac function. Methods A systematic literature search was performed using MEDLINE, EMBASE, and the Cochrane Library to identify RCTs comparing RVNA pacing with RVA pacing with follow-up ≥2 months. Twenty RCTs involving 1,114 patients were included. Results Compared with RVA pacing, RVNA (mainly right ventricular septum [RVS]) pacing exhibited not only excellent pacing threshold and R-wave amplitude but also higher impedance. RVNA pacing showed a significant increase in left ventricular ejection fraction (LVEF) at the end of follow-up (weighted mean difference = 3.58, 95% confidence interval = 1.80–5.35), and the effects were observed in the following subgroups: 6-month follow-up, ≤12-month follow-up, >12-month follow-up, baseline LVEF ≤45%, and baseline LVEF >45%. RVS and RVA pacing significantly differed in improving LVEF (weighted mean difference = 4.82, 95% confidence interval = 2.78–6.87). In addition, RVNA pacing resulted in a narrower QRS duration, a smaller left ventricular end-systolic volume, and a lower New York Heart Association functional class. Conclusions This meta-analysis found that RVNA (mainly RVS) pacing exhibited satisfactory long-term lead performance compared with RVA pacing and demonstrated beneficial effects in improving LVEF after the 6-month follow-up. Furthermore, it proved superior to RVA pacing in terms of interventricular synchrony and cardiac function.

This paper reports a high accuracy oil-filled MEMS absolute pressure sensor based on quartz crystal double-ended tuning fork (DETF) resonator, which is suitable for application in ocean, petroleum, meteorological, aerospace and spacecraft field, etc. The pressure sensing unit is mainly composed of DETF resonator, diaphragm and back cavity structure. These pieces are all fabricated by quartz crystal using MEMS process, and are bonded together as ‘sandwich’ structure to form the absolute pressure sensing unit using glass frit under low temperature and vacuum condition. This process could effectively eliminate the thermal stress effect and form the reference vacuum cavity. The isolated packaged pressure sensor is composed of corrugated stainless steel diaphragm, silicone oil, pressure sensing unit and ceramic base package. The experimental results show that the accuracy is up to ±0.033% FS in the pressure range 0~300 kPa over the temperature range −20 °C~+45 °C.

Earthquake-triggered landslides have drawn much attention around the world because of the severe hazards they pose. The 20 April 2013 Ms = 7.0 Lushan Earthquake, which occurred in the Longmen Shan region in Sichuan province, China, triggered more than 1000 landslides throughout an area of about 2200 km2, and completely blocked many roads and exacerbated overall transportation problems in the mountainous terrain. Preliminary landslide inventory is complied immediately following the earthquake, mainly based on the high-resolution remote sensing images. At the same time, the distribution of these landslides is statistically investigated to determine how the occurrence of landslides correlates with distance from the earthquake epicenter, slope steepness, seismic intensity and rock type. Statistic analysis is conducted using landslide point density (LPD), which is defined as the number of landslides per square kilometer. It is found that LPD has a strong positive correlation with slope gradients and a negative-exponential decline with the distance from the epicenter. The higher LPD values occur in younger strata systems like Quaternary and Tertiary sediments in the study area. Spatially, the triggered landslides are controlled by the causative faults and mainly concentrated around the epicenter. All the landslides are located within the area with seismic intensity ≥ VII and in line with seismic intensity. Generally, LPD value decreases with increasing distance from the epicenter, and sometimes landslides are densely distributed along the roads in the mountainous region. Also, this study reveals that the empirical relationship between distance and seismic magnitude is more suitable for estimating the landslide concentration area during the Lushan earthquake compared to other methods.

In order to make a better understanding of force transition and stability mechanism of granular materials in meso-scale, a series of photoelastic experiments are carried out. The formation and evolution of force chains in the process of particle flowing are observed. Under varies loading and flowing conditions, the mesoscopic structures of force chain are observed within granular media. It shows that arching phenomena can be recognized near the flowing site as particle flowing. When particles flow through the bottom gate, a parabolic arch formed by strong force chains grows; and a semi-arch deviates, when particles flow through a lateral gate. The arching effect shield stress from transferring to the flowing region. As a result, a great number of weak force chains concentrate around the flowing spot. And the arch changes in a periodic pattern and the force chain network is updated continually as particle flowing continues. The development trend of force chains as a whole depends on particle flowing as well as loading directions. Compared with the vertical growth of force chains under a tangential load, they extend mainly along a horizontal trend when a tangential load is applied to the model.

The mechanical properties of granular system are more complicated, compared with that of other systems. It is difficult to describe the interactions between particles. The force chain structures, as a result of particle contacts, can be showed directly by photoelastic experiments. In order to have a better understanding of mechanical properties and natural qualities in particle material, it is of great importance and convenience to study the characteristics of force chain distribution in granular systems. This work carries out a series of photoelastic experiments simulating certain geological conditions, provides an access to identify and extract the force chains using the ArcGIS software, and compares the analysis results with the experimental phenomena. It shows that the force chain structure can be presented clearly and completely after identified by ArcGIS. The evolution process of force chains, obtained through this method, confirms to the experimental expression. It is a significant attempt to analyze results of photoelastic experiments.

In order to solve the issues in the production and application of titanium dioxide, an amorphous silica/anatase composite was prepared through mechanochemical method. The prepared composite was characterised by laser particle size analyser, hiding power test, X-ray diffraction, SEM and infrared spectroscopy methods. The results showed that the properties of the composite are similar to those of titania. The optimum ratio of amorphous silica to anatase, rotation speed, reaction time, slurry density and dispersants amount for the preparation of the composite are 3∶7, 1400 rev min−1, 80 min, 10% and 4% respectively. The hiding power of the amorphous silica/anatase composite could reach 13·07 g m−2, which is better than pure anatase, indicating that the composite could replace titanium dioxide in some areas.

To create image objects for subsequent classification in object-based image analysis, an optimal segmentation threshold (OST) is a pre-requisite for image segmentation. However, an OST is practically acquired by assessing and ranking an exhaustive segment data stack constructed after foregoing image segmentation. In this paper, we propose an iterative exploration method via recognition of the Euclidean distance 2 (ED2)–scale parameter (SP) pattern with the least five tiles of segment data stack in each cycle among the Potential Segmentation Error (PSE)–Number-of-Segments Ratio (NSR)–ED2 patterns along with SP. We conducted two experiments. In the first experiment, we validated the general italic U-shaped ED2–SP pattern by constructing exhaustive segment data stacks and corresponding segment data stacks. In the second experiment, we adopted the proposed iterative exploration method for OST selection based on the ED2–SP pattern with respect to five equal-spacing SPs in each cycle. The bottom of the pattern was persistently approached by constructing updated segment data stacks and corresponding segment data stacks with five dynamically adjusted tiles. Our results showed that the PSE–NSR–ED2 discrepancy measure system is advantageous to OST selection

The traditional Chinese medicine Chan Su (toad venom) comprises dried secretions of the ear-side gland of Bufo gargarizans. Chan Su is known for its small molecular components, which include telocinobufagin, marinobufagin, and bufalin, while in other amphibians, studies mainly focus on peptide components. Until recently, no genes expressed in the ear-side gland of B. gargarizans gland had been cloned. In this study, cathelicidin-Bg, a coding sequence of anti-microbial peptide (AMP), was cloned. The predicted amino acid sequence of cathelicidin-Bg was very similar to that from other amphibians, with a 34-amino acid mature peptide predicted in the C-terminus. The functions of this mature peptide were verified by microbe and tumor cell inhibition assays. Our results showed that the mature peptide of cathelicidin-Bg could inhibit the proliferation of Staphylococcus aureus and Pseudomonas aeruginosa. The mature peptide was also shown to selectively inhibit tumor cells. These results indicate that the identified coding sequence represents an active peptide of Chan Su.

This paper presents a millimeter-wave network analyzer incorporating two six-port correlators for the measurement of the reflection and transmission coefficients of a device under test in the frequency band 59-61 GHz. An instrumentation integrating the hardware and software resources, including advantages such as robustness, compactness, relatively low cost, small size, and real-time operation, is developed. The millimeter-wave part of the system is implemented on a thin alumina ceramic substrate. The proposed solution eliminates the need for complex heterodyne schemes and for bulky tuning mechanisms generally found in dual six-port network analyzers. Associated to this system, an explicit calibration procedure is proposed. The performance, in terms of measurement accuracy, is evaluated by comparing the results obtained from the system proposed with those given by a conventional network analyzer.