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The article is devoted to the creation of a method for generating anthropomorphic brain models based on magnetic resonance imaging. The selection of the magnetic field amplitude for transcranial magnetic stimulation (TMS) is carried out through modeling using the finite element method (FEM). These FEM models graphically demonstrate information on the distribution of the magnetic field and, therefore, on the occurring neurophysiological and behavioral changes based on the dose of the TMS, the specific resistance of the head tissue and its anatomy. Thus, these models are an integral tool used to design, configure, and program TMS devices, as well as to study parameters such as magnetic field strength and tension. A distinctive aspect of this work is the quality of the resulting head models. When creating the calculated FEM models, an MRI image of the head was used to perform segmentation in the FreeSurfer environment. Next, the image was converted in the Matlab environment. After the assembly of the head model in COMSOL Multiphysics, the TMS was simulated. The results of the transformations is a head model made in the form of a three-dimensional grid, which is suitable for modeling. The obtained data can be used to personalize the TMS method in medicine.

The purpose of the work was to conduct modeling of hemodynamics of blood flow and study the hemodynamic characteristics of blood vessels. 3D models of the carotid artery were constructed based on images of a computer tomography in the 3D SLICER software package. The resulting model phantoms are modeled in the FlowVision software package using the finite element method. The most dangerous pathologies of the geometry of the vascular bed affecting the change in the hemodynamic characteristics of the blood flow were identified. The greatest danger in lowering the flow velocity in the lumen of the vessel was the tortuosity pathology (up to 30%). Pathology during the formation of aneurysms to a small extent influenced the decrease in speed (up to 8%). The danger of this pathology was to increase the pressure exerted by the blood stream on the wall of the aneurysm. The formation of atherosclerotic plaques in the lumen of the vessel led to a slowdown (up to 25%) and an increase in pressure in the area of plaque formation.

In modern clinical practice, the assessment of the state of blood microcirculation and the diagnosis of microcirculatory disorders are extremely relevant in a variety of diseases: in cardiology, diabetology, oncology, dermatology, dentistry, surgery and resuscitation. Microcirculatory disorders are very diverse both in their pathogenesis and in clinical manifestations. Therefore, in the pattern of various diseases and extreme conditions, as well as in the correction of microcirculatory disorders the methods are needed for both operative assessment of the state of blood flow at tissue level and for its long-term monitoring. The interest in the study of the microvascular bed of the circulatory system is sparked by the significant role of capillaries in the implementation of the basic processes of the body's vital activity, in the trophic support of organs and their direct participation in tissue and cellular respiration. The health and life expectancy of a person depend on the coordinated work of the heart, large blood lines, and microcirculation vessels. The authors have studied modern optical methods for diagnosing microcirculation. The feasibility of using the speckle imaging method for noninvasive rapid assessment of the state of the microvasculature of human surface biological tissues has been substantiated. To implement the speckle-visualization method, methodological and software have been developed. The processing parameters that are most optimal from the point of view of the ratio of spatiotemporal resolution and computation time have been experimentally substantiated. The purpose of this work is the experimental testing of the developed methodological and hardware speckle imaging for the diagnosis of microcirculation of human surface biological tissues. The authors have carried out the studies of the state of microcirculation in the superficial blood vessels of the skin during physiotherapeutic procedures and in the imitation of pathology. The results of the studies have proved the feasibility of using the developed software for a high-quality diagnosis of the state of microcirculation of human surface biological tissues: primary changes in microcirculation are revealed, further changes to occur during physiotherapeutic procedures are visualized.

The methodical and hardware-software on the basis of processing and analysis of speech signals for operative and objective diagnostics of neurological pathologies accompanied by speech function disorders are offered. The testing of developed methodological and software tools was carried out on the basis of the Republican Scientific and Practical Center of Neurology and Neurosurgery of the Ministry of Healthcare of Belarus and the Belarusian State University of Informatics and Radioelectronics. The results of testing revealed qualitative (based on the obtained spectrogram, kepstrogram, histogram) and quantitative (based on calculated parameters) differences between the parameters of speech signals in normal and bulbar syndrome. Preliminary results of the research confirmed the feasibility of using the methodological and hardware-software for registration and processing speech signals for diagnosis of neurological diseases.

The method of physiological efficiency assessment of electrical stimulation signals signals with various parameters on the base of time-frequency analysis of stimulated muscle global electromyogram is developed. As criterion of efficiency it is offered to use an indicator of relative change of ratio of amplitude to effective bandwidth frequency of global electromyograms registered before and after electrical stimulation. The above described method is used for the efficiency assessment of rectangular bipolar signals with frequency of 50-1000 Hz and the sinusoidal modulated currents with carrying frequency of 2-5 kHz and frequency of modulation of 25-150 Hz. The results of this work can be interesting for developer of the electromyography and electrical stimulation systems, as well as for electrophysiologists and physiatrists.

The method of qualitative and quantitative differential diagnosis of bulbar palsy has been offered on the basis of digital processing of speech signals. The software with the graphic user interface has been developed by authors for implementation of this method which allows to increase the accuracy and speed of diagnosis.

The device has been developed to restore the human body functional state. The device provides the effect of low intensity infrared (IR) radiation. It is a closed cabin with door, air ventilation system, IR sources, reflectors to protect a person's head, sensors of temperature and humidity, timer. Infrared cabin increases the efficiency of IR heating of human body through the use of the primarily near infrared range emitters. The advantages are also the lack of excessive heat load on the cardiovascular system and minimize energy costs.

The article is devoted to the problem of the analysis of person motion pattern stability. The estimation of person motion pattern variability on the basis of electrophysiological and biomechanical parameters of movement has been offered. Such approach allows defining stability of the motion action result without dependence from the movement force, but in consideration of level of the muscles participation and level of the movement phases importance. Investigation of the person motion pattern variability for the test movement has been executed.

Methodical and software has designed to implement the method of speckle visualization. The treatment options has experimentally grounded. They are the most optimal from the point of view of compliance with the space-time resolution and computation time.