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1. Corrigendum: 'Measurement of 73Ge(n,γ) cross sections and implications for stellar nucleosynthesis' [Phys. Lett. B 790 (2019) 458–465]

Author: C. Lederer-Woods, U. Battino, P. Ferreira, A. Gawlik, C. Guerrero, F. Gunsing, S. Heinitz, J. Lerendegui-Marco, A. Mengoni, R. Reifarth, A. Tattersall, S. Valenta, C. Weiss, O. Aberle, J. Andrzejewski, L. Audouin, V. Bécares, M. Bacak, J. Balibrea, M. Barbagallo, S. Barros, F. Bečvář, C. Beinrucker, F. Belloni, E. Berthoumieux, J. Billowes, D. Bosnar, M. Brugger, M. Caamaño, F. Calviño, M. Calviani, D. Cano-Ott, F. Cerutti, E. Chiaveri, N. Colonna, G. Cortés, M.A. Cortés-Giraldo, L. Cosentino, L.A. Damone, K. Deo, M. Diakaki, M. Dietz, C. Domingo-Pardo, R. Dressler, E. Dupont, I. Durán, B. Fernández-Domínguez, A. Ferrari, P. Finocchiaro, R.J.W. Frost, V. Furman, K. Göbel, A.R. García, I. Gheorghe, T. Glodariu, I.F. Gonçalves, E. González-Romero, A. Goverdovski, E. Griesmayer, H. Harada, T. Heftrich, A. Hernández-Prieto, J. Heyse, D.G. Jenkins, E. Jericha, F. Käppeler, Y. Kadi, T. Katabuchi, P. Kavrigin, V. Ketlerov, V. Khryachkov, A. Kimura, N. Kivel, I. Knapova, M. Kokkoris, M. Krtička, E. Leal-Cidoncha, H. Leeb, M. Licata, S. Lo Meo, R. Losito, D. Macina, J. Marganiec, T. Martínez, C. Massimi, P. Mastinu, M. Mastromarco, F. Matteucci, E. Mendoza, P.M. Milazzo, F. Mingrone, M. Mirea, S. Montesano, A. Musumarra, R. Nolte, F.R. Palomo-Pinto, C. Paradela, N. Patronis, A. Pavlik, J. Perkowski, J.I. Porras, J. Praena, J.M. Quesada, T. Rauscher, A. Riego-Perez, M. Robles, C. Rubbia, J.A. Ryan, M. Sabaté-Gilarte, A. Saxena, P. Schillebeeckx, S. Schmidt, D. Schumann, P. Sedyshev, A.G. Smith, A. Stamatopoulos, S.V. Suryanarayana, G. Tagliente, J.L. Tain, A. Tarifeño-Saldivia, L. Tassan-Got, A. Tsinganis, G. Vannini, V. Variale, P. Vaz, A. Ventura, V. Vlachoudis, R. Vlastou, A. Wallner, S. Warren, M. Weigand, T. Wright, and P. Žugec
Subjects: Physics, QC1-999
Published: 2023
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2. Enhancing clinician participation in quality improvement training: implementation and impact of an evidence-based initiative to maximise antenatal clinician participation in training regarding women’s alcohol consumption during pregnancy

Author: J. Dray, M. Licata, E. Doherty, B. Tully, B. Williams, S. Curtin, D. White, C. Lecathelinais, S. Ward, S. Hasson, E. J. Elliott, J. Wiggers, and M. Kingsland
Subjects: Training, Quality improvement, Maternity, Alcohol, Public aspects of medicine, RA1-1270
Abstract: Abstract Background There are significant challenges in ensuring sufficient clinician participation in quality improvement training. Clinician capability has been identified as a barrier to the delivery of evidence-based care. Clinician training is an effective strategy to address this barrier, however, there are significant challenges in ensuring adequate clinician participation in training. This study aimed to assess the extent of participation by antenatal clinicians in evidence-based training to address alcohol consumption during pregnancy, and to assess differences in participation by profession. Methods A 7-month training initiative based on six evidence-based principles was implemented in a maternity service in New South Wales, Australia. Descriptive statistics described participation in training (% attending: any training; six evidence-based principles of training; all principles). Regression analyses examined differences by profession. Results Almost all antenatal clinicians participated in some training (182/186; 98%); 69% participated in ≥1 h of training (μ = 88.2mins, SD:56.56). The proportion of clinicians participating in training that satisfied each of the six principles ranged from 35% (training from peers and experts) to 82% (training was educational and instructional). Only 7% participated in training that satisfied all principles. A significantly higher proportion of midwifery compared to medical clinicians participated in training satisfying five of the six training principles. Conclusions A training initiative based on evidence-based principles resulted in almost all clinicians receiving some training and 69% participating in at least 1 h of training. Variability between professions suggests training needs to be tailored to such groups. Further research is required to determine possible associations with care delivery outcomes. Trial registration Australian and New Zealand Clinical Trials Registry, No. ACTRN12617000882325 (date registered: 16/06/2017).
Published: 2022
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3. Measurement of 73Ge(n,γ) cross sections and implications for stellar nucleosynthesis

Author: C. Lederer-Woods, U. Battino, P. Ferreira, A. Gawlik, C. Guerrero, F. Gunsing, S. Heinitz, J. Lerendegui-Marco, A. Mengoni, R. Reifarth, A. Tattersall, S. Valenta, C. Weiss, O. Aberle, J. Andrzejewski, L. Audouin, V. Bécares, M. Bacak, J. Balibrea, M. Barbagallo, S. Barros, F. Bečvář, C. Beinrucker, F. Belloni, E. Berthoumieux, J. Billowes, D. Bosnar, M. Brugger, M. Caamaño, F. Calviño, M. Calviani, D. Cano-Ott, F. Cerutti, E. Chiaveri, N. Colonna, G. Cortés, M.A. Cortés-Giraldo, L. Cosentino, L.A. Damone, K. Deo, M. Diakaki, M. Dietz, C. Domingo-Pardo, R. Dressler, E. Dupont, I. Durán, B. Fernández-Domínguez, A. Ferrari, P. Finocchiaro, R.J.W. Frost, V. Furman, K. Göbel, A.R. García, I. Gheorghe, T. Glodariu, I.F. Gonçalves, E. González-Romero, A. Goverdovski, E. Griesmayer, H. Harada, T. Heftrich, A. Hernández-Prieto, J. Heyse, D.G. Jenkins, E. Jericha, F. Käppeler, Y. Kadi, T. Katabuchi, P. Kavrigin, V. Ketlerov, V. Khryachkov, A. Kimura, N. Kivel, I. Knapova, M. Kokkoris, M. Krtička, E. Leal-Cidoncha, H. Leeb, M. Licata, S. Lo Meo, R. Losito, D. Macina, J. Marganiec, T. Martínez, C. Massimi, P. Mastinu, M. Mastromarco, F. Matteucci, E. Mendoza, P.M. Milazzo, F. Mingrone, M. Mirea, S. Montesano, A. Musumarra, R. Nolte, F.R. Palomo-Pinto, C. Paradela, N. Patronis, A. Pavlik, J. Perkowski, J.I. Porras, J. Praena, J.M. Quesada, T. Rauscher, A. Riego-Perez, M. Robles, C. Rubbia, J.A. Ryan, M. Sabaté-Gilarte, A. Saxena, P. Schillebeeckx, S. Schmidt, D. Schumann, P. Sedyshev, A.G. Smith, A. Stamatopoulos, S.V. Suryanarayana, G. Tagliente, J.L. Tain, A. Tarifeño-Saldivia, L. Tassan-Got, A. Tsinganis, G. Vannini, V. Variale, P. Vaz, A. Ventura, V. Vlachoudis, R. Vlastou, A. Wallner, S. Warren, M. Weigand, T. Wright, and P. Žugec
Subjects: Physics, QC1-999
Abstract: 73Ge(n,γ) cross sections were measured at the neutron time-of-flight facility n_TOF at CERN up to neutron energies of 300 keV, providing for the first time experimental data above 8 keV. Results indicate that the stellar cross section at kT=30 keV is 1.5 to 1.7 times higher than most theoretical predictions. The new cross sections result in a substantial decrease of 73Ge produced in stars, which would explain the low isotopic abundance of 73Ge in the solar system. Keywords: Nucleosynthesis, Neutron capture, s process, Germanium, n_TOF
Published: 2019
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4. Agronomic Evaluation of Ethiopian Mustard (brassica Carinata A. Braun) Germplasm and Physical-energy Characterization of Crop Residues in a Semi-arid Area of Sicily (italy)

Author: M. Licata, S. La Bella, C. Leto, G. Bonsangue, M.C. Gennaro, and T. Tuttolomondo
Subjects: Chemical engineering, TP155-156, Computer engineering. Computer hardware, TK7885-7895
Abstract: Brassica carinata A. Braun is one of the most interesting oilseed crops suited to arid and semi-arid areas for energy purposes. Several studies have highlighted the possibility of introducing this species into cropping systems, typical of Mediterranean region. The aims of this study were to evaluate the agronomic performance of Brassica carinata germplasm under Mediterranean climatic conditions and to assess the physical and energy characteristics of crop residues and pellets made from the residues. A total of 20 different accessions of Brassica carinata were compared in a semi-arid area of Sicily (Italy). In the two-year test period, the main morphological and yield parameters of the accessions were recorded. Crop residues were characterized by determining the moisture content, the ash content and the gross calorific value. The crop residues were tested for pellet-making and the end product was analysed for its physical and energy properties by determining the ash content, gross calorific value and mechanical durability. For crop residues, differences were found to be highly significant for the moisture content and not significant for the gross calorific value. For pellet, differences were highly significant for all parameters in the study.
Published: 2017
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5. Elementary sensory-motor transformations underlying olfactory navigation in walking fruit-flies

Author: Efrén Álvarez-Salvado, Angela M Licata, Erin G Connor, Margaret K McHugh, Benjamin MN King, Nicholas Stavropoulos, Jonathan D Victor, John P Crimaldi, and Katherine I Nagel
Subjects: olfaction, behavior, navigation, computation, Medicine, Science, Biology (General), QH301-705.5
Abstract: Odor attraction in walking Drosophila melanogaster is commonly used to relate neural function to behavior, but the algorithms underlying attraction are unclear. Here, we develop a high-throughput assay to measure olfactory behavior in response to well-controlled sensory stimuli. We show that odor evokes two behaviors: an upwind run during odor (ON response), and a local search at odor offset (OFF response). Wind orientation requires antennal mechanoreceptors, but search is driven solely by odor. Using dynamic odor stimuli, we measure the dependence of these two behaviors on odor intensity and history. Based on these data, we develop a navigation model that recapitulates the behavior of flies in our apparatus, and generates realistic trajectories when run in a turbulent boundary layer plume. The ability to parse olfactory navigation into quantifiable elementary sensori-motor transformations provides a foundation for dissecting neural circuits that govern olfactory behavior.
Published: 2018
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6. Wildflowers: opportunities for urban landscapes

Author: D. Farruggia, N. Iacuzzi, M. Licata, S. La Bella, T. Tuttolomondo, G. Virga, Davide Farruggia, Nicolò Iacuzzi, Mario Licata, Salvatore La Bella, Teresa Tuttolomondo, and Giuseppe Virga
Subjects: wildflower, ornamental plants, urban sustainability, biometric characteristic, biodiversity, Horticulture, Settore AGR/02 - Agronomia E Coltivazioni Erbacee
Abstract: The concept of “sustainability” is also becoming of great interest in the management of ornamental and territorial greenery. The new trends in the design of green spaces are aimed both at enhancing their “natural” aspects and at researching schemes characterized by lower maintenance costs. Spontaneous vegetation represents a characteristic component of the urban environment and is always adequate to the conditions of the site in which it is located. In this context, the role of spontaneous herbaceous plants becomes fundamental and constitutes an effective response to the current demand for the defence, conservation and enhancement of biodiversity. So far, the use of spontaneous vegetation for ornamental purposes, in public and private areas, is somewhat limited. The full potential of wild herbaceous species is often not achieved due to a lack of planning, management and limited species-specific knowledge. The objective of the work concerned the determination of some biometric characteristics of spontaneous herbaceous species found in the urban area of the city of Palermo in order to identify the best ones such as wildflower. The survey involved 18 species belonging to 13 different botanical families. The most represented families are Asteraceae, Poaceae and Brassicaceae. It emerged that the plants had diversified sizes always characterized by a high showiness of the floral structures. Although the Mediterranean flora is generally dominated by yellow flower structures, during the survey plants with white, pink, lilac, orange, lilac-violet and violet flowers were found, which are interesting for a possible use as wildflowers. Finally, the heterogeneity of the height found in the different plants allows us to support the possibility of using the species in various combinations in relation to the type of area to be planted.
Published: 2022

7. Spontaneous urban weeds: a resource against environmental pollution

Author: N. Iacuzzi, D. Farruggia, M. Licata, Y. Bellone, T. Tuttolomondo, G. Virga, Nicolò Iacuzzi, Davide Farruggia, Mario Licata, yuri Bellone, Teresa Tuttolomondo, and Giuseppe Virga
Subjects: potentially toxic metals, weeds, biomonitoring, urban areas, Horticulture, Settore AGR/02 - Agronomia E Coltivazioni Erbacee
Abstract: Quality of the environment and social well-being, both at a collective and individual level, are closely interrelated issues. It is, in fact, a relationship that invests values of primary importance, such as those relating to human health and safety, heritage and resources to be passed on to future generations. Plant growth and survival can be challenged by harsh urban conditions. Many studies show the persistence of endemic species in built-up areas and document the ecosystem services provided. With this research we wanted to investigate the bioaccumulation of heavy metals such as cobalt (Co), nickel (Ni), copper (Cu), zinc (Zn), arsenic (As), molibden (Mo), cadmium (Cd), lead (Pb) and mercury (Hg), in some spontaneous plants found along Viale Regione Siciliana, the most important thoroughfare of the city of Palermo with high traffic intensity. In two distinct seasons (spring and summer), the most present spontaneous plants were collected: Daucus carota, Verbascum sinuatum, Sorghum halepense and Plantago lanceolata; after, the plants were subjected to drying and analysis for the survey of heavy metals. The results were comforting as the four species all accumulated the metals investigated, albeit with different selectivity. In both seasons, the most present element was Zn, while the other elements, such as Co, Ni, As, Mo, Cd, Cu and Cd, underwent significant fluctuations. Only Hg exceeded the critical values in both seasons and in all the species examined. Furthermore, it had an opposite trend compared to the other elements, finding itself in greater concentration in the tissues of plants during the summer season. The investigation, albeit preliminary, confirmed the ability of some herbaceous plants to accumulate heavy metals, suggesting the use of a set of herbaceous plants for biomonitoring in response to the need for monitoring and verifying environmental sustainability.
Published: 2022

8. Constructed wetlands as nature-based solution for sustainable wastewater management in urban areas: a critical assessment by experimental studies and literature

Author: M. Licata, G. Virga, C. Leto, D. Farruggia, Y. Bellone, N. Iacuzzi, Mario Licata, Giuseppe Virga, Claudio Leto, Davide Farruggia, Yuri Bellone, and Nicolò Iacuzzi
Subjects: constructed wetlands, stormwater, urban wastewater, reuse, sustainability, Horticulture, Settore AGR/02 - Agronomia E Coltivazioni Erbacee
Abstract: In urban areas, constructed wetland systems (CWS) have been recognized as one of the most valid technologies for sustainable wastewater management. They represent green infrastructure and provide solutions to treatment of wastewaters that cities and peri-urban areas produce in large amount. In particular, CWS offer the advantages of wastewater reuse for parklands irrigation, water storage and peak-flow attenuation, control of stormwater runoff, nutrient cycling and uptake, heavy metals sequestration, removal of organic compounds. In greener cities, these systems have the potential to perform not just hydrological and wastewater treatment functions, but also urban design and ecological aspects as demonstrated by numerous applications around the world. CWS, in fact, can function as urban wildlife sites, educational or recreational facilities, landscape engineering and ecological areas. The aim of this paper was to highlight the potential functionality of CWS in urban areas by a critical assessment of two experimental studies and literature. In particular, the two studies were carried out in Sicily (Italy) in order to evaluate: i) the pollutant removal efficiency of two CWS to treat urban wastewater and first-flush stormwater; ii) the reuse of treated wastewater for irrigation of plants. The results confirm that CWS are efficient in the treatment and reuse of wastewater for irrigation purposes in modern cities. Furthermore, CWS showed very high organic pollutant removal and a good efficiency in reducing excess of nutrients and trace metals, highlighting their important role in the treatment of stormwater in urban areas.
Published: 2022

9. A neural circuit for wind-guided olfactory navigation

Author: Andrew M.M. Matheson, Aaron J. Lanz, Al M. Licata, Mubarak Hussain Syed, Timothy A. Currier, and Katherine I. Nagel
Subjects: Multidisciplinary, Computer science, General Physics and Astronomy, General Chemistry, Wind, Wind direction, ENCODE, General Biochemistry, Genetics and Molecular Biology, Smell, Odor, Odorants, Connectome, Spatial cues, Animals, Drosophila, Cues, Olfactory navigation, Neuroscience, Spatial analysis
Abstract: To navigate towards a food source, animals must frequently combine odor cues, that tell them what sources are useful, with spatial cues such as wind direction that tell them where the odor can be found. Previous studies have identified wind-direction inputs that provide spatial information to the Drosophila navigation center, but olfactory inputs to this structure have not been functionally characterized. Here we use a high-throughput behavioral screen to identify a pathway linking olfactory centers to a part of the navigation center called the fan-shaped body (FB). We show that neurons throughout this pathway promote upwind movement, but encode odor independent of wind direction. We identify a type of FB local neuron that receives input from both wind-encoding and odor-encoding pathways, integrates these cues, and drives turning behavior. Based on connectome data, we develop a computational model that shows how the architecture of the FB enables odor input to flexibly gate behavioral responses to wind direction. Our work supports a model in which spatial and non-spatial information enter the FB through anatomically distinct pathways, and are integrated in FB local neurons to promote context-appropriate navigation behaviors.
Published: 2021

10. Strands algebras and the affine highest weight property for equivariant hypertoric categories

Author: Aaron D. Lauda, Anthony M. Licata, and Andrew Manion
Subjects: 16G99, 57K18, 14M25, 17B37, 17B15, Mathematics - Geometric Topology, Mathematics::K-Theory and Homology, General Mathematics, Mathematics - Quantum Algebra, FOS: Mathematics, Quantum Algebra (math.QA), Geometric Topology (math.GT), Representation Theory (math.RT), Mathematics::Representation Theory, Mathematics::Geometric Topology, Mathematics::Symplectic Geometry, Mathematics - Representation Theory
Abstract: We show that the equivariant hypertoric convolution algebras introduced by Braden-Licata-Proudfoot-Webster are affine quasi hereditary in the sense of Kleshchev and compute the Ext groups between standard modules. Together with the main result of arXiv:2009.03981, this implies a number of new homological results about the bordered Floer algebras of Ozsvath-Szabo, including the existence of standard modules over these algebras. We prove that the Ext groups between standard modules are isomorphic to the homology of a variant of the Lipshitz-Ozsvath-Thurston bordered strands dg algebras., v2 corrects typos and adds several examples
Published: 2021

11. Enhancing clinician participation in quality improvement training: implementation and impact of an evidence-based initiative to maximise antenatal clinician participation in training regarding women's alcohol consumption during pregnancy

Author: J. Dray, M. Licata, E. Doherty, B. Tully, B. Williams, S. Curtin, D. White, C. Lecathelinais, S. Ward, S. Hasson, E. J. Elliott, J. Wiggers, and M. Kingsland
Subjects: Alcohol Drinking, Pregnancy, Health Policy, education, Australia, Humans, Female, New South Wales, Midwifery, Quality Improvement
Abstract: Background There are significant challenges in ensuring sufficient clinician participation in quality improvement training. Clinician capability has been identified as a barrier to the delivery of evidence-based care. Clinician training is an effective strategy to address this barrier, however, there are significant challenges in ensuring adequate clinician participation in training. This study aimed to assess the extent of participation by antenatal clinicians in evidence-based training to address alcohol consumption during pregnancy, and to assess differences in participation by profession. Methods A 7-month training initiative based on six evidence-based principles was implemented in a maternity service in New South Wales, Australia. Descriptive statistics described participation in training (% attending: any training; six evidence-based principles of training; all principles). Regression analyses examined differences by profession. Results Almost all antenatal clinicians participated in some training (182/186; 98%); 69% participated in ≥1 h of training (μ = 88.2mins, SD:56.56). The proportion of clinicians participating in training that satisfied each of the six principles ranged from 35% (training from peers and experts) to 82% (training was educational and instructional). Only 7% participated in training that satisfied all principles. A significantly higher proportion of midwifery compared to medical clinicians participated in training satisfying five of the six training principles. Conclusions A training initiative based on evidence-based principles resulted in almost all clinicians receiving some training and 69% participating in at least 1 h of training. Variability between professions suggests training needs to be tailored to such groups. Further research is required to determine possible associations with care delivery outcomes. Trial registration Australian and New Zealand Clinical Trials Registry, No. ACTRN12617000882325 (date registered: 16/06/2017).
Published: 2021

12. Museums and human remains: Ethical issues in curating and displaying

Author: M. Licata, Rosagemma Ciliberti, F. Monza, and R. D’Anastasio
Subjects: Cultural heritage, Issues, ethics and legal aspects, Health (social science), History, Ethical issues, Mental hospital, Health Policy, Donation, Subject (philosophy), Environmental ethics, Exposition (narrative), Italian literature
Abstract: Summary In this contribution, we would like to address the ethical issues concerning detention and exposition in museums of human remains. Italian literature on the subject is still very poor in contrast with other countries. We will present two emblematic examples of complex cases involving Italian museums, requiring ethical reflection. The first is the case of the Gorini Collection (Lodi) and the recent donation of the mummies of the “Giuseppe Paravicini Collection” belonged to incurable patients of the mental hospital of Mombello, near Milan. The second is the case of the mummified remains of the head of a Celano child in the anthropological section of Chieti's University Museum, also known as “Celano child”. These cases highlight and examine the difficult and problematic issues of accessibility and providing safeguard for cultural heritage and also ethical order.
Published: 2019

13. Gastrointestinal Bleeding In Covid-19 Patients: A Systematic Review And Meta-Analysis

Author: M. Licata, Vincenzo Stanghellini, Giovanni Marasco, Cesare Cremon, Giovanni Barbara, M. Maida, and Gaetano Cristian Morreale
Subjects: Gastrointestinal bleeding, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Geographic area, business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Confounding, MEDLINE, Cochrane Library, medicine.disease, Meta-analysis, Internal medicine, Medicine, business
Abstract: Aims The novel SARS-CoV-2 disease (COVID-19) has been reported to affect the gastrointestinal (GI) system with a widevariety of symptoms, including GI bleeding. The aim of this meta-analysis is to estimate the rate of GI bleeding of patientsinfected with SARS-CoV-2. Methods MEDLINE via PubMed, Ovid Embase, Scopus and Cochrane Library were systematically searched through October,10th 2020. Studies simultaneously reporting cohorts of COVID-19 patients with and without GI bleeding were included. Arandom-effect model was applied for pooling results;heterogeneity was expressed as I . Impact of confounding covariateson the meta-analytic results was evaluated using meta-regression analysis. Results Seven studies (including a total of 1047 COVID-19 patients) met the inclusion criteria and were included in theanalysis. Among COVID-19 patients with gastrointestinal bleeding, 93 experienced upper and 21 lower GI bleeding. The mean age ofparticipants ranged from 45.3 to 73.7 years. Four studies have been carried out in Western countries (2 in the US, 1 in Italyand 1 in Israel), and 3 in Eastern countries (China). Three studies reported the rate of patients taking anticoagulants orantiplatelets, ranging from 37.4 % to 100 %. The overall pooled bleeding rate was 9 % [95 % CI: 2 % to 20 %], with highheterogeneity (I 96.4 %), and no “small study effect” observed using the Egger test (p = 0.979). The pooled uppergastrointestinal bleeding rate was 7 % (95 % CI: 1 % to 17 %, I 95.3 %, Egger test p = 0.835), whereas the pooled lowergastrointestinal bleeding rate was 1 % (95 % CI: 0 % to 4 %, I 82.4 %, Egger test p = 0.437). Meta-regression analysisshowed that overall risk bleeding was significantly affected by the geographic area of the study (β 0.899±0.027) and theupper source of bleeding (β 1.010±0.003). Conclusions In this meta-analysis of published studies, individuals with SARS-CoV-2 infections were found to be at risk forGI bleeding, especially upper GI bleeding.
Published: 2021

14. Investigation of the Pu240(n,f) reaction at the n_TOF/EAR2 facility in the 9 meV–6 MeV range

Author: R. J. W. Frost, A. Goverdovski, A. Mengoni, M. Krtička, V. Furman, T. J. Wright, I. Duran, G. Tagliente, Petar Žugec, Javier Praena, S. Lo Meo, T. Martinez, L. Cosentino, K. Deo, G. Vannini, V. Ketlerov, D. Bosnar, E. Dupont, A. Musumarra, Tatsuya Katabuchi, A. Ventura, M. Mirea, M. Mastromarco, S. Warren, A. Kimura, S. Heinitz, V. Variale, S. Barros, A. Tsinganis, Massimo Barbagallo, F. R. Palomo-Pinto, M. Caamaño, Rene Reifarth, E. Chiaveri, D. G. Jenkins, Anton Wallner, Stefan Schmidt, C. Paradela, Rugard Dressler, F. Calviño, Tanja Heftrich, P. F. Mastinu, L. Audouin, M. Licata, H. Leeb, J. M. Quesada, L. Tassan-Got, J. Balibrea, S. V. Suryanarayana, F. Mingrone, C. Lederer, I. Knapova, A. Riego-Perez, J. Perkowski, R. Vlastou, J. Marganiec, S. Valenta, Ariel Tarifeño-Saldivia, A. J. M. Plompen, F. Gunsing, P. Vaz, N. Colonna, Marco Calviani, E. Berthoumieux, P. Kavrigin, Ralf Nolte, A. G. Smith, M. A. Cortés-Giraldo, F. Cerutti, Cristian Massimi, A. Pavlik, E. Leal-Cidoncha, O. Aberle, E. Griesmayer, L. A. Damone, C. Domingo-Pardo, Hideo Harada, A. Hernández-Prieto, M. Sabaté-Gilarte, Kathrin Göbel, Vasilis Vlachoudis, V. Bécares, M. S. Robles, Thomas Rauscher, Jan Heyse, M. Kokkoris, C. Rubbia, Pedro G. Ferreira, Mario Weigand, C. Weiss, D. Cano-Ott, Y. Kadi, M. Diakaki, F. Bečvář, M. Bacak, E. Mendoza, Peter Schillebeeckx, J. Lerendegui-Marco, D. Macina, Carlos Guerrero, J. L. Tain, J. I. Porras, T. Glodariu, Roberto Losito, I. F. Gonçalves, Niko Kivel, B. Fernández-Domínguez, E. González-Romero, F. Käppeler, Fabio Belloni, A. R. García, Francesca Matteucci, M. Brugger, C. Beinrucker, V. Khryachkov, P. M. Milazzo, Ioana Gheorghe, N. Patronis, A. K. Saxena, Arnaud Ferrari, S. Montesano, J. Billowes, E. Jericha, A. Stamatopoulos, Paolo Finocchiaro, Dorothea Schumann, J. A. Ryan, P. V. Sedyshev, J. Andrzejewski, and G. Cortes
Subjects: Physics, Nuclear transmutation, 010308 nuclear & particles physics, Fission, Monte Carlo method, Radioactive waste, MicroMegas detector, 7. Clean energy, 01 natural sciences, Neutron temperature, Spent nuclear fuel, Nuclear physics, 0103 physical sciences, Neutron, Nuclear Experiment, 010306 general physics
Abstract: Background: Nuclear waste management is considered amongst the major challenges in the field of nuclear energy. A possible means of addressing this issue is waste transmutation in advanced nuclear systems, whose operation requires a fast neutron spectrum. In this regard, the accurate knowledge of neutron-induced reaction cross sections of several (minor) actinide isotopes is essential for design optimization and improvement of safety margins of such systems. One such case is Pu240, due to its accumulation in spent nuclear fuel of thermal reactors and its usage in fast reactor fuel. The measurement of the Pu240(n,f) cross section was previously attempted at the CERN n_TOF facility EAR1 measuring station using the time-of-flight technique. Due to the low amount of available material and the given flux at EAR1, the measurement had to last several months to achieve a sufficient statistical accuracy. This long duration led to detector deterioration due to the prolonged exposure to the high α activity of the fission foils, therefore the measurement could not be successfully completed. Purpose: It is aimed to determine whether it is feasible to study neutron-induced fission at n_TOF/EAR2 and provide data on the Pu240(n,f) reaction in energy regions requested for applications. Methods: The study of the Pu240(n,f) reaction was made at a new experimental area (EAR2) with a shorter flight path which delivered on average 30 times higher flux at fast neutron energies. This enabled the measurement to be performed much faster, thus limiting the exposure of the detectors to the intrinsic activity of the fission foils. The experimental setup was based on microbulk Micromegas detectors and the time-of-flight data were analyzed with an optimized pulse-shape analysis algorithm. Special attention was dedicated to the estimation of the non-negligible counting loss corrections with the development of a new methodology, and other corrections were estimated via Monte Carlo simulations of the experimental setup. Results: This new measurement of the Pu240(n,f) cross section yielded data from 9meV up to 6MeV incident neutron energy and fission resonance kernels were extracted up to 10keV. Conclusions: Neutron-induced fission of high activity samples can be successfully studied at the n_TOF/EAR2 facility at CERN covering a wide range of neutron energies, from thermal to a few MeV.
Published: 2020

15. RESIST-HCV criteria are able to rule out esophageal varices progression in patients with HCV cirrhosis treated by Direct-acting Antiviral Agents(DAAs)

Author: V. Calvaruso, S. Petta, M. Licata, F. Simone, L. Di Marco, L. Crapanzano, C. Cammà, A. Craxì, and V. Di Marco
Subjects: Hepatology, Gastroenterology
Published: 2021

16. AF.87 RESIST-HCV CRITERIA ARE ABLE TO RULE OUT ESOPHAGEAL VARICES PROGRESSION IN PATIENTS WITH HCV CIRRHOSIS TREATED BY DIRECT-ACTING ANTIVIRAL AGENTS(DAAS)

Author: M. Licata, Antonio Craxì, Y. Abdel Hadi, L. Crapanzano, V. Di Martino, S. Petta, L. Di Marco, V. Di Marco, C. Cammà, F. Simone, and Vincenza Calvaruso
Subjects: medicine.medical_specialty, Cirrhosis, Esophageal varices, Hepatology, business.industry, Internal medicine, Gastroenterology, medicine, In patient, medicine.disease, business, Direct acting
Published: 2021

17. Measurement of 73Ge(n,g) cross sections and implications for stellar nucleosynthesis

Author: S. Montesano, V. Khryachkov, A. Tsinganis, Alfredo Ferrari, F. R. Palomo-Pinto, Nicola Colonna, E. Dupont, A. Goverdovski, G. Tagliente, J. Heyse, A. Musumarra, Claudia Lederer-Woods, M. Mastromarco, F. Gunsing, Cristian Massimi, Pedro G. Ferreira, Mario Weigand, I. Duran, E. Mendoza, Anton Wallner, M. Bacak, P. V. Sedyshev, M. Mirea, J. Balibrea, V. Furman, F. Calviño, H. Leeb, Ioana Gheorghe, J. Perkowski, Tanja Heftrich, S. Heinitz, J. Billowes, M. Sabaté-Gilarte, A. Kimura, Francesca Matteucci, A. Riego-Perez, T. Glodariu, M. Krtička, A. Hernández-Prieto, S. Warren, V. Bécares, L. Cosentino, N. Patronis, R. Dressler, Roberto Losito, M. S. Robles, T. Martinez, E. Jericha, C. Weiss, D. Macina, R. Vlastou, V. Variale, Paolo Finocchiaro, A. Stamatopoulos, P. M. Milazzo, O. Aberle, J. A. Ryan, D. G. Jenkins, E. Berthoumieux, Mario Barbagallo, M. Diakaki, Alberto Mengoni, J. Marganiec, Carlos Guerrero, F. Bečvář, A. Saxena, S. V. Suryanarayana, D. Schumann, Damir Bosnar, Y. Kadi, E. González-Romero, P. F. Mastinu, A. Tattersall, P. Schillebeeckx, Hideo Harada, M. A. Cortés-Giraldo, P. Kavrigin, F. Mingrone, S. Valenta, J. Andrzejewski, Ralf Nolte, Marco Calviani, V. Vlachoudis, M. Kokkoris, Rene Reifarth, E. Griesmayer, A. G. Smith, Petar Žugec, C. Paradela, M. Dietz, Stefan Schmidt, L. A. Damone, L. Audouin, J. M. Quesada, L. Tassan-Got, K. Göbel, B. Fernández-Domínguez, F. Käppeler, T. Wright, Tatsuya Katabuchi, S. Barros, U. Battino, A. Pavlik, C. Domingo-Pardo, E. Chiaveri, D. Cano-Ott, J. I. Porras, I. Knapova, P. Vaz, Alberto Ventura, C. Rubbia, J. L. Tain, Niko Kivel, G. Cortes, J. Lerendegui-Marco, A. R. García, M. Brugger, I. F. Gonçalves, R. J. W. Frost, C. Beinrucker, E. Leal-Cidoncha, Javier Praena, S. Lo Meo, Fabio Belloni, G. Vannini, A. Gawlik, Thomas Rauscher, Ariel Tarifeño-Saldivia, M. Licata, K. Deo, M. Caamaño, V. Ketlerov, F. Cerutti, Lederer-Woods, C., Battino, U., Ferreira, P., Gawlik, A., Guerrero, C., Gunsing, F., Heinitz, S., Lerendegui-Marco, J., Mengoni, A., Reifarth, R., Tattersall, A., Valenta, S., Weiss, C., Aberle, O., Andrzejewski, J., Audouin, L., Becares, V., Bacak, M., Balibrea, J., Barbagallo, M., Barros, S., Becvar, F., Beinrucker, C., Belloni, F., Berthoumieux, E., Billowes, J., Bosnar, D., Brugger, M., Caamano, M., Calvino, F., Calviani, M., Cano-Ott, D., Cerutti, F., Chiaveri, E., Colonna, N., Cortes, G., Cortes-Giraldo, M. A., Cosentino, L., Damone, L. A., Deo, K., Diakaki, M., Dietz, M., Domingo-Pardo, C., Dressler, R., Dupont, E., Duran, I., Fernandez-Dominguez, B., Ferrari, A., Finocchiaro, P., Frost, R. J. W., Furman, V., Gobel, K., Garcia, A. R., Gheorghe, I., Glodariu, T., Goncalves, I. F., Gonzalez-Romero, E., Goverdovski, A., Griesmayer, E., Harada, H., Heftrich, T., Hernandez-Prieto, A., Heyse, J., Jenkins, D. G., Jericha, E., Kappeler, F., Kadi, Y., Katabuchi, T., Kavrigin, P., Ketlerov, V., Khryachkov, V., Kimura, A., Kivel, N., Knapova, I., Kokkoris, M., Krticka, M., Leal-Cidoncha, E., Leeb, H., Licata, M., Lo Meo, S., Losito, R., Macina, D., Marganiec, J., Martinez, T., Massimi, C., Mastinu, P., Mastromarco, M., Matteucci, F., Mendoza, E., Milazzo, P. M., Mingrone, F., Mirea, M., Montesano, S., Musumarra, A., Nolte, R., Palomo-Pinto, F. R., Paradela, C., Patronis, N., Pavlik, A., Perkowski, J., Porras, J. I., Praena, J., Quesada, J. M., Rauscher, T., Riego-Perez, A., Robles, M., Rubbia, C., Ryan, J. A., Sabate-Gilarte, M., Saxena, A., Schillebeeckx, P., Schmidt, S., Schumann, D., Sedyshev, P., Smith, A. G., Stamatopoulos, A., Suryanarayana, S. V., Tagliente, G., Tain, J. L., Tarifeno-Saldivia, A., Tassan-Got, L., Tsinganis, A., Vannini, G., Variale, V., Vaz, P., Ventura, A., Vlachoudis, V., Vlastou, R., Wallner, A., Warren, S., Weigand, M., Wright, T., Zugec, P., Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), n_TOF, Ministerio de Economía y Competitividad (España), Bécares, V., Bečvář, F., Caamaño, M., Calviño, F., Cortés, G., Cortés-Giraldo, M.A., Damone, L.A., Durán, I., Fernández-Domínguez, B., Frost, R.J.W., Göbel, K., García, A.R., Gonçalves, I.F., González-Romero, E., Hernández-Prieto, A., Jenkins, D.G., Käppeler, F., Krtička, M., Martínez, T., Milazzo, P.M., Palomo-Pinto, F.R., Porras, J.I., Quesada, J.M., Ryan, J.A., Sabaté-Gilarte, M., Smith, A.G., Suryanarayana, S.V., Tain, J.L., Tarifeño-Saldivia, A., Žugec, P., Universitat Politècnica de Catalunya. Departament de Física, Universitat Politècnica de Catalunya. ANT - Advanced Nuclear Technologies Research Group, and Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)
Subjects: Nucleosynthesis, Neutron capture, s process, Germanium, n_TOF, s proce, Nuclear reaction, Natural abundance, nucl-ex, 01 natural sciences, 7. Clean energy, Stellar nucleosynthesis, CERN, Astrophysics::Solar and Stellar Astrophysics, n_TOF, Nuclear Experiment (nucl-ex), Nuclear Experiment, Physics, Cross section, Germanium, lcsh:QC1-999, PRIRODNE ZNANOSTI. Fizika, Neutron capture, Nucleosynthesis, s process, Nucleosíntesi, Nuclear and High Energy Physics, nTOF, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Neutron, Neutrons--Captura, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], Neutrons--Capture, Nuclear physics, 0103 physical sciences, Nuclear Physics - Experiment, 010306 general physics, Nucleosynthesi, Energies::Energia nuclear [Àrees temàtiques de la UPC], Física [Àrees temàtiques de la UPC], 010308 nuclear & particles physics, Capture cross section, NATURAL SCIENCES. Physics, Stars, 13. Climate action, s-process, lcsh:Physics
Abstract: 73Ge(n, γ) cross sections were measured at the neutron time-of-flight facility n_TOF at CERN up to neutron energies of 300keV, providing for the first time experimental data above 8keV. Results indicate that the stellar cross section at kT=30keV is 1.5 to 1.7 times higher than most theoretical predictions. The new cross sections result in a substantial decrease of 73Ge produced in stars, which would explain the low isotopic abundance of 73Ge in the solar system., This work was supported by the Austrian Science Fund FWF (J3503), the Adolf Messer Foundation (Germany), the UK Science and Facilities Council (ST/M006085/1), and the European Research Council ERC-2015-StG Nr.677497.
Published: 2019
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18. Elementary sensory-motor transformations underlying olfactory navigation in walking fruit-flies

Author: John P. Crimaldi, Efrén Álvarez-Salvado, Jonathan D. Victor, Benjamin M.N. King, Angela M. Licata, Margaret K. McHugh, Nicholas Stavropoulos, Erin Connor, and Katherine I. Nagel
Subjects: 0301 basic medicine, computation, QH301-705.5, Computer science, Science, Sensory system, Olfaction, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, Biological neural network, Biology (General), Olfactory navigation, navigation, Acetic Acid, Sensory motor, General Immunology and Microbiology, D. melanogaster, behavior, General Neuroscience, General Medicine, Attraction, 030104 developmental biology, Odor, Odorants, Medicine, Off response, Neuroscience, 030217 neurology & neurosurgery, psychological phenomena and processes, Research Article, olfaction
Abstract: Odor attraction in walking Drosophila melanogaster is commonly used to relate neural function to behavior, but the algorithms underlying attraction are unclear. Here, we develop a high-throughput assay to measure olfactory behavior in response to well-controlled sensory stimuli. We show that odor evokes two behaviors: an upwind run during odor (ON response), and a local search at odor offset (OFF response). Wind orientation requires antennal mechanoreceptors, but search is driven solely by odor. Using dynamic odor stimuli, we measure the dependence of these two behaviors on odor intensity and history. Based on these data, we develop a navigation model that recapitulates the behavior of flies in our apparatus, and generates realistic trajectories when run in a turbulent boundary layer plume. The ability to parse olfactory navigation into quantifiable elementary sensori-motor transformations provides a foundation for dissecting neural circuits that govern olfactory behavior., eLife digest All kinds of animals use their sense of smell to find things. Doing this is difficult because odors in air travel as plumes, which meander downwind and break apart. Scientists are interested in learning the rules that animals use to decipher these odor signals and trace them back to their source. For example, do animals use patterns of timing in the odor, differences between smell at the two nostrils, or the direction of the wind? Scientists would also like to know how animal’s brain circuits decipher this information. Tiny fruit flies make a good model for studying the way animals detect odors because scientists have already learned a great deal about how their brains work. There are also many tools available to help scientists study the brain circuits of fruit flies. Now, Álvarez-Salvado et al. show that fruit flies use multiple senses to track odors to their source. In the experiments, fruit flies that were blind and could not fly were placed in tiny wind tunnels and their behavior in response to a smell or no smell in the tunnel was carefully documented. When the flies detected an odor, they turned to face the wind using their antennae to detect wind direction and run toward it. When flies lost track of an odor they began to search for it at the spot where they last smelled it. Next, Álvarez-Salvado et al. created a computer model that recreated the flies’ behavior and was able to find the odor source as well as real flies. The model added together these basic behaviors to successfully recreate the flies’ odor-search strategy. Other animals are often better than humans at finding odor sources. As a result, people use pigs to find truffles and dogs to find lost hikers. The computer model Álvarez-Salvado et al. developed might help design robots that can search for truffles, hikers, or landmines, without risking the lives of animals. It might also be useful for designing autonomous vehicles that must respond to many types of information in changing environments to make decisions.
Published: 2018

19. Author response: Elementary sensory-motor transformations underlying olfactory navigation in walking fruit-flies

Author: Nicholas Stavropoulos, Katherine I. Nagel, Margaret K. McHugh, Erin Connor, Efrén Álvarez-Salvado, Benjamin Mn King, Jonathan D. Victor, Angela M. Licata, and John P. Crimaldi
Subjects: Sensory motor, Psychology, Olfactory navigation, Neuroscience
Published: 2018

20. Measurement and analysis of theAm241neutron capture cross section at the n_TOF facility at CERN

Author: J. Lerendegui-Marco, Carlos Guerrero, S. Andriamonje, I. Dillmann, Jan Heyse, P. E. Koehler, E. Leal-Cidoncha, C. Eleftheriadis, S. Altstadt, I. F. Gonçalves, E. Chiaveri, P. F. Mastinu, Thomas Rauscher, Fabio Belloni, C. Weiss, G. Tagliente, M. Mirea, S. Heinitz, V. Bécares, D. Karadimos, M. Mastromarco, P. V. Sedyshev, A. Mengoni, M. S. Robles, D. López, Massimo Barbagallo, Roberto Losito, N. Colonna, A. K. Saxena, F. Mingrone, C. Lederer, I. Duran, Tatsuya Katabuchi, A. Ventura, M. P. W. Chin, V. Ketlerov, F. Roman, Srinivasan Ganesan, F. Calviño, H. Leeb, C. Carrapiço, Arnaud Ferrari, C. Paradela, Anton Wallner, Ariel Tarifeño-Saldivia, M. B. Gomez-Hornillos, B. Berthier, F. Cerutti, J. Billowes, P. Gurusamy, L. Audouin, J. Balibrea, A. Goverdovski, M. J. Vermeulen, V. Khryachkov, A. Tsinganis, J. Andrzejewski, Tanja Heftrich, A. Hernández-Prieto, F. Bečvář, E. González, Jeri Kroll, P. Vaz, S. Valenta, J. Perkowski, L.S. Leong, A. Riego-Perez, P. M. Milazzo, D. Cano-Ott, A. R. García, Marco Calviani, T. Ware, Vasilis Vlachoudis, K. Fraval, R. Sarmento, M. Brugger, F. Gramegna, M. Kokkoris, E. Mendoza, E. Griesmayer, A. J. M. Plompen, M. Krtička, M. Diakaki, Javier Praena, F. Käppeler, V. Variale, Peter Schillebeeckx, N. Dzysiuk, Rene Reifarth, T. Martinez, Roberto Versaci, Willy Mondelaers, Christoph Langer, G. Giubrone, Stefan Schmidt, C. Lampoudis, A. Pavlik, Y. Kadi, C. Rubbia, Mario Weigand, A. Manousos, C. Domingo-Pardo, J. M. Quesada, L. Tassan-Got, E. Jericha, J. Marganiec, M. Sabaté-Gilarte, Dorothea Schumann, J. A. Ryan, F. Gunsing, J. L. Tain, D. Bosnar, Cristian Massimi, R. Vlastou, E. Berthoumieux, M. A. Cortés-Giraldo, Petar Žugec, G. Cortes, D. Tarrío, V. Furman, T. J. Wright, G. Vannini, D. G. Jenkins, and M. Licata
Subjects: Nuclear reaction, Physics, 010308 nuclear & particles physics, Resonance, 01 natural sciences, 7. Clean energy, Neutron temperature, Calorimeter, Nuclear physics, Cross section (physics), Neutron capture, 0103 physical sciences, Neutron cross section, Neutron, 010306 general physics
Abstract: The Am241(n,γ) cross section has been measured at the n-TOF facility at CERN with the n-TOF BaF2 Total Absorption Calorimeter in the energy range between 0.2 eV and 10 keV. Our results are analyzed as resolved resonances up to 700 eV, allowing a more detailed description of the cross section than in the current evaluations, which contain resolved resonances only up to 150-160 eV. The cross section in the unresolved resonance region is perfectly consistent with the predictions based on the average resonance parameters deduced from the resolved resonances, thus obtaining a consistent description of the cross section in the full neutron energy range under study. Below 20 eV, our results are in reasonable agreement with JEFF-3.2 as well as with the most recent direct measurements of the resonance integral, and differ up to 20-30% with other experimental data. Between 20 eV and 1 keV, the disagreement with other experimental data and evaluations gradually decreases, in general, with the neutron energy. Above 1 keV, we find compatible results with previously existing values.
Published: 2018

21. The course of oesophagogastric varices in patients with cirrhosis after DAA-induced HCV clearance

Author: Anna Licata, Elisabetta Conte, V. Di Marco, Antonio Craxì, Vincenza Calvaruso, Irene Cacciola, G. Raimondo, F. Simone, Salvatore Petta, Giuseppa Caccamo, Maria Giovanna Minissale, M. Licata, Giovanni Squadrito, Calvaruso, V., Cacciola, I., Petta, S., Caccamo, G., Conte, E., Minissale, M.G., Licata, M., Simone, F., Squadrito, G., Licata, A., Raimondo, G., Craxì, A., and Di Marco, V.
Subjects: medicine.medical_specialty, Cirrhosis, Hepatology, business.industry, Gastroenterology, Hcv clearance, medicine.disease, Internal medicine, oesophagogastric varices, cirrhosis, DAA, medicine, In patient, Varices, business
Abstract: Background and aims: Use of direct acting antivirals (DAAs) has allowed to clear HCV in almost all patients even in the presence of advanced cirrhosis. Although it has been suggested that cirrhotic portal hypertension may regress after SVR, the ultimate effect of HCV clearance on the development and progression of oesophagogastric varices (OV) is still unexplored. We assessed in a prospective cohort of patients with cirrhosis the evolution of endoscopic features of portal hypertension induced by SVR obtained with DAAs. Method: 321 consecutive patients (mean age: 65.1 ± 10.5, males: 58%) with HCV Child-Pugh A cirrhosis treated with DAAs were enrolled between January 2015 and May 2016. All patients underwent esophagogastroscopy (EGS), liver ultrasound (US), liver stiffness measurement (LSM) by Transient Elastography and laboratory tests before the starting DAAs and after achieving SVR. LS * spleen diameter/platelet ratio (LSPS) was calculated as previously described [1]. Results: Forty-one patients were excluded from the analysis, 32(10%) since they had F2/F3 OV at baseline, and 9(2.8%) since they did not achieve SVR. Overall, 280 SVR patients were analysed. At baseline, 100 patients (35.7%) did not have OV and 180(64.3%) had small OV. None received beta-blockers. After a median time of 24.6 months EGS showed de novo development of OV in 24/100(24%) patients and progression from F1 to F2/F3 OV in 30/180 patients (16.7%), p = 0.68 by Kaplan–Meier. By Cox regression analysis, LSPS as continuum variable (HR: 1.06, CI95%: 1.01–1.11, p = 0.025) or at a cut off ≥ 3(HR: 3.16, CI95%: 1.64–6.09, p = 0.001) was associated with OV progression. Age (p = 0.15), gender (p = 0.93) and BMI (p = 0.07) did not correlate with progression of OV. Conclusion: Progression of clinically significant portal hypertension, as assessed by the evolution of oesophagogastric varices, is not uncommon among patients with HCV cirrhosis after HCV clearance. Non-invasive evaluation using combined data of LS, spleen diameter, and platelet count can assist in identifying patients in whom portal hypertension is likely to progress notwithstanding SVR.
Published: 2018

22. Braid groups of type ADE, Garside monoids, and the categorified root lattice

Author: Anthony M. Licata, Hoel Queffélec, Institut Montpelliérain Alexander Grothendieck (IMAG), and Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: General Mathematics, Mathematics::Category Theory, Mathematics - Quantum Algebra, FOS: Mathematics, Quantum Algebra (math.QA), Group Theory (math.GR), [MATH]Mathematics [math], Representation Theory (math.RT), Mathematics - Group Theory, Mathematics - Representation Theory, ComputingMilieux_MISCELLANEOUS
Abstract: We study Artin-Tits braid groups $\mathbb{B}_W$ of type ADE via the action of $\mathbb{B}_W$ on the homotopy category $\mathcal{K}$ of graded projective zigzag modules (which categorifies the action of the Weyl group $W$ on the root lattice). Following Brav-Thomas, we define a metric on $\mathbb{B}_W$ induced by the canonical $t$-structure on $\mathcal{K}$, and prove that this metric on $\mathbb{B}_W$ agrees with the word-length metric in the canonical generators of the standard positive monoid $\mathbb{B}_W^+$ of the braid group. We also define, for each choice of a Coxeter element $c$ in $W$, a baric structure on $\mathcal{K}$. We use these baric structures to define metrics on the braid group, and we identify these metrics with the word-length metrics in the Birman-Ko-Lee/Bessis dual generators of the associated dual positive monoid $\mathbb{B}_{W.c}^\vee$. As consequences, we give new proofs that the standard and dual positive monoids inject into the group, give linear-algebraic solutions to the membership problem in the standard and dual positive monoids, and provide new proofs of the faithfulness of the action of $\mathbb{B}_W$ on $\mathcal{K}$. Finally, we use the compatibility of the baric and $t$-structures on $\mathcal{K}$ to prove a conjecture of Digne and Gobet regarding the canonical word-length of the dual simple generators of ADE braid groups., Comment: 40 pages
Published: 2017
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23. High-accuracy determination of the neutron flux in the new experimental area n_TOF-EAR2 at CERN

Author: D. Cano-Ott, A. Pavlik, C. Domingo-Pardo, P. Vaz, Alberto Ventura, G. Vannini, Y. H. Chen, F. Bečvář, M. Caamaño, G. Tagliente, C. Wolf, M. Licata, Peter Schillebeeckx, J. Billowes, V. Bécares, O. Aberle, A. Villacorta, R. J. W. Frost, M. S. Robles, F. Belloni, J. Andrzejewski, M. Bacak, D. G. Jenkins, M. Sabaté-Gilarte, V. Ketlerov, E. Jericha, R. Baccomi, F. R. Palomo-Pinto, E. González, F. Cerutti, M. Diakaki, Paolo Finocchiaro, K. Rajeev, Dorothea Schumann, Francesca Matteucci, Luigi Cosentino, M. A. Cortés-Giraldo, C. Weiss, J. I. Porras, T. Glodariu, Roberto Losito, J. A. Ryan, B. Fernández-Domínguez, A. R. García, F. Käppeler, A. Oprea, Y. Kadi, C. Rubbia, M. Brugger, J. Lerendegui-Marco, N. Patronis, C. Beinrucker, A. K. Saxena, R. Cardella, Hideo Harada, M. Mastromarco, I. F. Gonçalves, E. Leal-Cidoncha, Arnaud Ferrari, V. Khryachkov, A. Gawlik, Anton Wallner, Thomas Rauscher, Rugard Dressler, P. M. Milazzo, J. L. Tain, Javier Praena, S. Lo Meo, J. Balibrea, Niko Kivel, P. Kavrigin, A. Tsinganis, Ralf Nolte, A. Casanovas, M. Piscopo, Nicola Colonna, E. Griesmayer, Ariel Tarifeño-Saldivia, S. J. Lonsdale, M. Krtička, Emilio Andrea Maugeri, Vasilis Vlachoudis, Tatsuya Katabuchi, S. Valenta, Alberto Mengoni, T. Martinez, Marco Calviani, T. Papaevangelou, M. Kokkoris, S. Barros, A. G. Smith, I. Duran, Philip Woods, A. Hernández-Prieto, L. A. Damone, Rene Reifarth, J. Marganiec, Stefan Schmidt, J. M. Quesada, L. Tassan-Got, E. Chiaveri, G. Cortés, P. F. Mastinu, S. Warren, V. Variale, P. V. Sedyshev, A. Musumarra, K. Deo, D. M. Castelluccio, Tanja Heftrich, A. Riego-Perez, D. Macina, Carlos Guerrero, C. Paradela, S. Heinitz, L. Audouin, Kathrin Göbel, Jan Heyse, V. Furman, T. J. Wright, E. Mendoza, R. Vlastou, E. Berthoumieux, Petar Žugec, A. Kimura, Mario Barbagallo, S. V. Suryanarayana, A. Goverdovski, M. Mirea, F. Calviño, H. Leeb, J. Perkowski, Pedro G. Ferreira, Mario Weigand, F. Gunsing, Cristian Massimi, E. Dupont, Ioana Gheorghe, S. Montesano, A. Stamatopoulos, P. C. Rout, F. Mingrone, C. Lederer, D. Bosnar, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Sabaté-Gilarte, M., Barbagallo, M., Colonna, N., Gunsing, F., Žugec, P., Vlachoudis, V., Chen, Y. H., Stamatopoulos, A., Lerendegui-Marco, J., Cortés-Giraldo, M. A., Villacorta, A., Guerrero, C., Damone, L., Audouin, L., Berthoumieux, E., Cosentino, L., Diakaki, M., Finocchiaro, P., Musumarra, A., Papaevangelou, T., Piscopo, M., Tassan-Got, L., Aberle, O., Andrzejewski, J., Bécares, V., Bacak, M., Baccomi, R., Balibrea, J., Barros, S., Bečvář, F., Beinrucker, C., Belloni, F., Billowes, J., Bosnar, D., Brugger, M., Caamaño, M., Calviño, F., Calviani, M., Cano-Ott, D., Cardella, R., Casanovas, A., Castelluccio, D. M., Cerutti, F., Chiaveri, E., Cortés, G., Deo, K., Domingo-Pardo, C., Dressler, R., Dupont, E., Durán, I., Fernández-Domínguez, B., Ferrari, A., Ferreira, P., Frost, R. J. W., Furman, V., Göbel, K., García, A. R., Gawlik, A., Gheorghe, I., Glodariu, T., Gonçalves, I. F., González, E., Goverdovski, A., Griesmayer, E., Harada, H., Heftrich, T., Heinitz, S., Hernández-Prieto, A., Heyse, J., Jenkins, D. G., Jericha, E., Käppeler, F., Kadi, Y., Katabuchi, T., Kavrigin, P., Ketlerov, V., Khryachkov, V., Kimura, A., Kivel, N., Kokkoris, M., Krtička, M., Leal-Cidoncha, E., Lederer, C., Leeb, H., Licata, M., Lo Meo, S., Lonsdale, S. J., Losito, R., Macina, D., Marganiec, J., Martínez, T., Massimi, C., Mastinu, P., Mastromarco, M., Matteucci, F., Maugeri, E. A., Mendoza, E., Mengoni, A., Milazzo, P. M., Mingrone, F., Mirea, M., Montesano, S., Nolte, R., Oprea, A., Palomo-Pinto, F. R., Paradela, C., Patronis, N., Pavlik, A., Perkowski, J., Porras, J. I., Praena, J., Quesada, J. M., Rajeev, K., Rauscher, T., Reifarth, R., Riego-Perez, A., Robles, M. S., Rout, P. C., Rubbia, C., Ryan, J. A., Saxena, A., Schillebeeckx, P., Schmidt, S., Schumann, D., Sedyshev, P., Smith, A. G., Suryanarayana, S. V., Tagliente, G., Tain, J. L., Tarifeño-Saldivia, A., Tsinganis, A., Valenta, S., Vannini, G., Variale, V., Vaz, P., Ventura, A., Vlastou, R., Wallner, A., Warren, S., Weigand, M., Wolf, C., Woods, P. J., Weiss, C., Wright, T., Universitat Politècnica de Catalunya. Departament de Física, Universitat Politècnica de Catalunya. Institut de Tècniques Energètiques, and Universitat Politècnica de Catalunya. ANT - Advanced Nuclear Technologies Research Group
Subjects: Nuclear and High Energy Physics, Astrophysics::High Energy Astrophysical Phenomena, Flux, Neutron, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 7. Clean energy, 01 natural sciences, Nuclear physics, n-tof, Neutron flux, 0103 physical sciences, CERN, Spallation, 010306 general physics, Nuclear Experiment, n_TOF, EAR2, neutron flux measurement, Physics, Energies::Energia nuclear [Àrees temàtiques de la UPC], Neutrons, Física [Àrees temàtiques de la UPC], 010308 nuclear & particles physics, Neutron radiation, Neutron temperature, Radiation flux, Physics::Accelerator Physics, Beam (structure)
Abstract: A new high flux experimental area has recently become operational at the n_TOF facility at CERN. This new measuring station, n_TOF-EAR2, is placed at the end of a vertical beam line at a distance of approximately 20m from the spallation target. The characterization of the neutron beam, in terms of flux, spatial profile and resolution function, is of crucial importance for the feasibility study and data analysis of all measurements to be performed in the new area. In this paper, the measurement of the neutron flux, performed with different solid-state and gaseous detection systems, and using three neutron-converting reactions considered standard in different energy regions is reported. The results of the various measurements have been combined, yielding an evaluated neutron energy distribution in a wide energy range, from 2meV to 100MeV, with an accuracy ranging from 2%, at low energy, to 6% in the high-energy region. In addition, an absolute normalization of the n_TOF-EAR2 neutron flux has been obtained by means of an activation measurement performed with 197Au foils in the beam. © 2017, SIF, Springer-Verlag GmbH Germany.
Published: 2017

24. Measurement of the 241Am neutron capture cross section at the n-TOF facility at CERN

Author: C. Carrapiço, Tanja Heftrich, Rene Reifarth, I. Duran, M. S. Robles, A. Mengoni, M. P. W. Chin, V. Ketlerov, F. Roman, Javier Praena, E. Leal-Cidoncha, M. Mastromarco, Anton Wallner, Srinivasan Ganesan, J. Balibrea, Mario Barbagallo, F. Mingrone, J. Andrzejewski, C. Paradela, L. Audouin, A. Riego-Perez, M. Diakaki, D. Cano-Ott, P. Gurusamy, E. González, F. Käppeler, Jeri Kroll, C. Eleftheriadis, Thomas Rauscher, D. Karadimos, C. Domingo-Pardo, G. Vannini, Stefan Schmidt, A. Goverdovski, Vittorio Boccone, J. M. Quesada, L. Tassan-Got, Iris Dillmann, A. Hernández-Prieto, A. K. Saxena, Arnaud Ferrari, A. R. García, M. Brugger, L. S. Leong, Jan Heyse, M. Sabaté-Gilarte, A. Manousos, Mario Weigand, J. Billowes, G. Tagliente, F. Cerutti, F. Gunsing, M. Krtička, Tatsuya Katabuchi, P. E. Koehler, M. Fernandez-Ordonez, Cristian Massimi, P. V. Sedyshev, M. Licata, G. Giubrone, A. J. M. Plompen, F. Bečvář, T. Martinez, V. Khryachkov, Roberto Losito, T. Ware, P. M. Milazzo, F. Gramegna, M. Kokkoris, C. Weiss, E. Griesmayer, G. Cortes, E. Mendoza, D. Tarrío, J. Marganiec, S. Andriamonje, M. Mirea, Peter Schillebeeckx, Carlos Guerrero, V. Furman, T. J. Wright, N. Dzysiuk, M. A. Cortés-Giraldo, E. Chiaveri, S. Heinitz, F. Calviño, P. F. Mastinu, H. Leeb, J. Perkowski, C. Rubbia, V. Bécares, Petar Žugec, K. Fraval, S. Altstadt, M. B. Gómez-Hornillos, Christoph Langer, C. Lampoudis, A. Pavlik, A. Tsinganis, J. L. Tain, Nicola Colonna, E. Jericha, Vasilis Vlachoudis, Ariel Tarifeño-Saldivia, Dorothea Schumann, J. A. Ryan, R. Sarmento, R. Vlastou, J. Lerendegui-Marco, P. Vaz, E. Berthoumieux, Alberto Ventura, I. F. Gonçalves, D. G. Jenkins, Fabio Belloni, W. Mondelaers, V. Variale, Roberto Versaci, C. Lederer, Damir Bosnar, Y. Kadi, M. J. Vermeulen, B. Berthier, S. Valenta, Marco Calviani, Universidad de Sevilla. Departamento de Física Atómica, Molecular y Nuclear, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), n_TOF, Mengoni, A., Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Universitat Politècnica de Catalunya. Departament de Física, Universitat Politècnica de Catalunya. Departament de Física i Enginyeria Nuclear, Universitat Politècnica de Catalunya. ANT - Advanced Nuclear Technologies Research Group, Mendoza, E., Cano-Ott, D., Altstadt, S., Andriamonje, S., Andrzejewski, J., Audouin, L., Balibrea, J., Bécares, V., Barbagallo, M., Bečvář, F., Belloni, F., Berthier, B., Berthoumieux, E., Billowes, J., Boccone, V., Bosnar, D., Brugger, M., Calviño, F., Calviani, M., Carrapiço, C., Cerutti, F., Chiaveri, E., Chin, M., Colonna, N., Cortés, G., Cortés-Giraldo, M.A., Diakaki, M., Dillmann, I., Domingo-Pardo, C., Durán, I., Dzysiuk, N., Eleftheriadis, C., Fernández-Ordóñez, M., Ferrari, A., Fraval, K., Furman, V., Gómez-Hornillos, M.B., Ganesan, S., García, A.R., Giubrone, G., Gonçalves, I.F., González, E., Goverdovski, A., Gramegna, F., Griesmayer, E., Guerrero, C., Gunsing, F., Gurusamy, P., Heftrich, T., Heinitz, S., Hernández-Prieto, A., Heyse, J., Jenkins, D.G., Jericha, E., Käppeler, F., Kadi, Y., Karadimos, D., Katabuchi, T., Ketlerov, V., Khryachkov, V., Koehler, P., Kokkoris, M., Kroll, J., Krtička, M., Lampoudis, C., Langer, C., Leal-Cidoncha, E., Lederer, C., Leeb, H., Leong, L.S., Lerendegui-Marco, J., Licata, M., Losito, R., Manousos, A., Marganiec, J., Martínez, T., Massimi, C., Mastinu, P., Mastromarco, M., Milazzo, P.M., Mingrone, F., Mirea, M., Mondelaers, W., Paradela, C., Pavlik, A., Perkowski, J., Plompen, A.J.M., Praena, J., Quesada, J.M., Rauscher, T., Reifarth, R., Riego-Perez, A., Robles, M., Roman, F., Rubbia, C., Ryan, J.A., Sabaté-Gilarte, M., Sarmento, R., Saxena, A., Schillebeeckx, P., Schmidt, S., Schumann, D., Sedyshev, P., Tagliente, G., Tain, J.L., Tarifeño-Saldivia, A., Tarrío, D., Tassan-Got, L., Tsinganis, A., Valenta, S., Vannini, G., Variale, V., Vaz, P., Ventura, A., Vermeulen, M.J., Versaci, R., Vlachoudis, V., Vlastou, R., Wallner, A., Ware, T., Weigand, M., Weiss, C., Wright, T., and Ž Ugec, P.
Subjects: Nuclear reaction, Nuclear transmutation, nTOF, QC1-999, Neutron, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 01 natural sciences, 7. Clean energy, Nuclear physics, Physics and Astronomy (all), Cross section (physics), Nuclear reactors, Reactors nuclears, 0103 physical sciences, CERN, Neutron cross section, Nuclear Physics - Experiment, ddc:530, 010306 general physics, Absorption (electromagnetic radiation), Physics, Neutrons, Energies::Energia nuclear [Àrees temàtiques de la UPC], Large Hadron Collider, Cross section, Física [Àrees temàtiques de la UPC], 010308 nuclear & particles physics, Calorimeter
Abstract: New neutron cross section measurements of minor actinides have been performed recently in order to reduce the uncertainties in the evaluated data, which is important for the design of advanced nuclear reactors and, in particular, for determining their performance in the transmutation of nuclear waste. We have measured the 241 Am(n,γ) cross section at the n TOF facility between 0.2 eV and 10 keV with a BaF2 Total Absorption Calorimeter, and the analysis of the measurement has been recently concluded. Our results are in reasonable agreement below 20 eV with the ones published by C. Lampoudis et al. in 2013, who reported a 22% larger capture cross section up to 110 eV compared to experimental and evaluated data published before. Our results also indicate that the 241 Am(n,γ) cross section is underestimated in the present evaluated libraries between 20 eV and 2 keV by 25%, on average, and up to 35% for certain evaluations and energy ranges. Plan Nacional I+D+I FPA2014-53290-C2-1 Comisión Europea, ANDES FP7- 249671 Comisión Europea, CHANDA FP7-605203
Published: 2017

25. Measurement of the neutron capture cross section of the fissile isotope 235U with the CERN n-TOF total absorption calorimeter and a fission tagging based on micromegas detectors

Author: E. Jericha, Dorothea Schumann, J. A. Ryan, C. Paradela, G. Cortes, M. Mastromarco, V. Khryachkov, Rugard Dressler, P. M. Milazzo, M. A. Cortés-Giraldo, D. Tarrío, Rene Reifarth, A. Goverdovski, L. Audouin, C. Rubbia, J. Balibrea-Correa, A. Tsinganis, M. S. Robles, Nicola Colonna, Anton Wallner, Stefan Schmidt, Javier Praena, P. V. Sedyshev, Vasilis Vlachoudis, Jeri Kroll, S. Altstadt, G. Tagliente, P. E. Koehler, Srinivasan Ganesan, M. B. Gómez-Hornillos, Christoph Langer, K. Fraval, Petar Žugec, Mario Weigand, M. Diakaki, A. Mallick, J. M. Quesada, D. Cano-Ott, V. Bécares, G. Vannini, L. Tassan-Got, E. Mendoza, A. J. M. Plompen, G. Giubrone, C. Carrapiço, L. S. Leong, Mario Barbagallo, Carlos Guerrero, M. Krtička, A. Manousos, J. L. Tain, S. Heinitz, C. Weiss, F. Mingrone, J. Andrzejewski, V. Boccone, F. Bečvář, F. Cerutti, Niko Kivel, I. Duran, M. Sabaté-Gilarte, C. Lederer, C. Lampoudis, Roberto Losito, M. Licata, T. Martinez, A. Pavlik, Peter Schillebeeckx, C. Domingo-Pardo, Kathrin Göbel, J. Marganiec, M. Mirea, J. Lerendegui-Marco, Tatsuya Katabuchi, E. Chiaveri, P. F. Mastinu, F. Käppeler, Jan Heyse, R. Sarmento, D. G. Jenkins, P. Vaz, R. Vlastou, F. Calviño, H. Leeb, A. Hernández-Prieto, Alberto Ventura, E. Berthoumieux, J. Perkowski, F. Gunsing, I. F. Gonçalves, Cristian Massimi, W. Mondelaers, E. González, V. Furman, T. J. Wright, V. Variale, Tanja Heftrich, A. Riego-Perez, Fabio Belloni, M. Kokkoris, A. K. Saxena, Arnaud Ferrari, J. Billowes, Ariel Tarifeño-Saldivia, S. Valenta, Marco Calviani, M. J. Vermeulen, E. Leal-Cidoncha, C. Eleftheriadis, Damir Bosnar, Thomas Rauscher, Y. Kadi, D. Karadimos, T. Ware, E. Griesmayer, A. R. García, M. Brugger, A. Mengoni, M. P. W. Chin, V. Ketlerov, Mengoni, A., Universidad de Sevilla. Departamento de Física Atómica, Molecular y Nuclear, Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, n_TOF, Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Balibrea-Correa, J., Mendoza, E., Cano-Ott, D., Krtička, M., Altstadt, S., Andrzejewski, J., Audouin, L., Bécares, V., Barbagallo, M., Bečvář, F., Belloni, F., Berthoumieux, E., Billowes, J., Boccone, V., Bosnar, D., Brugger, M., Calviño, F., Calviani, M., Carrapiço, C., Cerutti, F., Chiaveri, E., Chin, M., Colonna, N., Cortés, G., Cortés-Giraldo, M.A., Diakaki, M., Domingo-Pardo, C., Dressler, R., Durán, I., Eleftheriadis, C., Ferrari, A., Fraval, K., Furman, V., Göbel, K., Guerrero, C., Gómez-Hornillos, M.B., Ganesan, S., García, A.R., Giubrone, G., Gonçalves, I.F., González, E., Goverdovski, A., Griesmayer, E., Gunsing, F., Heftrich, T., Heinitz, S., Hernández-Prieto, A., Heyse, J., Jenkins, D.G., Jericha, E., Käppeler, F., Kadi, Y., Karadimos, D., Katabuchi, T., Ketlerov, V., Khryachkov, V., Kivel, N., Koehler, P., Kokkoris, M., Kroll, J., Lampoudis, C., Langer, C., Leal-Cidoncha, E., Lederer, C., Leeb, H., Leong, L.S., Lerendegui-Marco, J., Licata, M., Losito, R., Mallick, A., Manousos, A., Marganiec, J., Martínez, T., Massimi, C., Mastinu, P., Mastromarco, M., Milazzo, P.M., Mingrone, F., Mirea, M., Mondelaers, W., Paradela, C., Pavlik, A., Perkowski, J., Plompen, A.J.M., Praena, J., Quesada, J.M., Rauscher, T., Reifarth, R., Riego-Perez, A., Robles, M., Rubbia, C., Ryan, J.A., Sabaté-Gilarte, M., Sarmento, R., Saxena, A., Schillebeeckx, P., Schmidt, S., Schumann, D., Sedyshev, P., Tagliente, G., Tain, J.L., Tarifeño-Saldivia, A., Tarrío, D., Tassan-Got, L., Tsinganis, A., Valenta, S., Vannini, G., Variale, V., Vaz, P., Ventura, A., Vermeulen, M.J., Vlachoudis, V., Vlastou, R., Wallner, A., Ware, T., Weigand, M., Weiss, C., Wright, T., Žugec, P., Universitat Politècnica de Catalunya. Departament de Física, Universitat Politècnica de Catalunya. Departament de Física i Enginyeria Nuclear, and Universitat Politècnica de Catalunya. ANT - Advanced Nuclear Technologies Research Group
Subjects: Nuclear reaction, nTOF, Fission, Physics::Instrumentation and Detectors, QC1-999, Nuclear Theory, Neutron, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 7. Clean energy, 01 natural sciences, Nuclear physics, Physics and Astronomy (all), 0103 physical sciences, CERN, Neutron cross section, ddc:530, Nuclear Physics - Experiment, 010306 general physics, Nuclear Experiment, Physics, Neutrons, Radioisotopes, Isòtops radioactius, Calorimeter (particle physics), Fissile material, cross section, 010308 nuclear & particles physics, Nuclear data, MicroMegas detector
Abstract: The accuracy on neutron capture cross section of fissile isotopes must be improved for the design of future nuclear systems such as Gen-IV reactors and Accelerator Driven Systems. The High Priority Request List of the Nuclear Energy Agency, which lists the most important nuclear data requirements, includes also the neutron capture cross sections of fissile isotopes such as 233,235U and 239,241Pu. A specific experimental setup has been used at the CERN n TOF facility for the measurement of the neutron capture cross section of 235U by a set of micromegas fission detectors placed inside a segmented BaF2 Total Absorption Calorimeter. Plan Nacional de I+D+I Física de particulas FPA2014-53290-C2-1
Published: 2017

26. The course of oesophagogastric varices in patients with cirrhosis after DAA-induced HCV clearance

Author: V. Calvaruso, I. Cacciola, S. Petta, G. Caccamo, E. Conte, M. Licata, F. Simone, G. Squadrito, G. Raimondo, A. Craxi, and V. DI Marco
Subjects: Hepatology
Published: 2018

27. Screening and linkage to care of prisoners with HCV infection: the RESIST-HCV project

Author: F. Cartabellota, Marcos A. Rossi, A. Busacca, S. Marchese, R. Insinna, Giacomo Emanuele Maria Rizzo, A. Di Lorenzo, F. Scalici, M. Licata, V. Di Marco, Maurizio Milesi, Tullio Prestileo, Ciro Celsa, and L. Di Marco
Subjects: Linkage (software), medicine.medical_specialty, Hepatology, business.industry, Family medicine, Gastroenterology, Medicine, business
Published: 2019

28. Nuclear data activities at the n_TOF facility at CERN

Author: Rene Reifarth, Stefan Schmidt, D. Radeck, J. M. Quesada, E. Berthoumieux, A. R. García, S. Montesano, P. Vaz, Rugard Dressler, I. Porras, G. Vannini, M. Brugger, P. C. Rout, Emilio Andrea Maugeri, A. Casanovas, A. Goverdovski, M. Caamaño, Alberto Ventura, C. Rubbia, C. Lederer, C. Beinrucker, M. Kokkoris, J. Balibrea-Correa, A. Tsinganis, F. Gunsing, M. Licata, M. Krtička, Nicola Colonna, Cristian Massimi, V. Furman, T. J. Wright, Tatsuya Katabuchi, A. Oprea, G. Cortes, D. Tarrío, Annamaria Mazzone, Petar Žugec, K. Deo, T. Martinez, V. Ketlerov, S. Warren, S. Barros, A. Kimura, D. Cano-Ott, Srinivasan Ganesan, K. Rajeev, J. Marganiec, J. L. Tain, V. Variale, R. J. W. Frost, V. Khryachkov, Francesca Matteucci, D. G. Jenkins, P. Kavrigin, M. Mirea, E. Mendoza, N. Patronis, E. Leal-Cidoncha, Niko Kivel, E. Chiaveri, Laurent Tassan-Got, F. R. Palomo-Pinto, E. Jericha, Hideo Harada, A. Pavlik, Ralf Nolte, Kathrin Göbel, C. Domingo-Pardo, A. K. Saxena, Arnaud Ferrari, A. Hernández-Prieto, P. F. Mastinu, J. Billowes, Mario Barbagallo, A. Gawlik, E. Griesmayer, Thomas Rauscher, F. Calviño, H. Leeb, L. A. Damone, Paolo Finocchiaro, Dorothea Schumann, J. A. Ryan, M. Mastromarco, S. Heinitz, Jan Heyse, M. S. Robles, A. Stamatopoulos, M. A. Cortés-Giraldo, Anton Wallner, I. F. Gonçalves, J. Perkowski, C. Paradela, M. Bacak, Y. H. Chen, M. Diakaki, Ioana Gheorghe, V. Bécares, E. González, I. Duran, Alberto Mengoni, T. Glodariu, Alessandro Masi, Roberto Losito, O. Aberle, P. M. Milazzo, Fabio Belloni, M. Sabaté-Gilarte, F. Bečvář, Pedro G. Ferreira, Mario Weigand, C. Wolf, Ariel Tarifeño-Saldivia, S. J. Lonsdale, Peter Schillebeeckx, Saraswatula Venkata Suryanarayana, J. Lerendegui, E. Dupont, Luigi Cosentino, B. Fernández-Domínguez, F. Käppeler, R. Cardella, F. Mingrone, J. Andrzejewski, V. Vlachoudis, L. Audouin, A. Musumarra, Javier Praena, S. Lo Meo, Tanja Heftrich, A. Riego-Perez, A. G. Smith, F. Cerutti, P. V. Sedyshev, D. M. Castelluccio, D. Macina, Carlos Guerrero, G. Tagliente, C. Weiss, R. Vlastou, Damir Bosnar, Y. Kadi, S. Valenta, Marco Calviani, Philip Woods, Universitat Politècnica de Catalunya. Departament de Física, Universitat Politècnica de Catalunya. Institut de Tècniques Energètiques, Universitat Politècnica de Catalunya. ANT - Advanced Nuclear Technologies Research Group, Mengoni, A., Lo Meo, S., Castelluccio, D. M., Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), n_TOF Collaboration, The n_TOF Collaboration, Null, Gunsing, F., Aberle, O., Andrzejewski, J., Audouin, L., Bécares, V., Bacak, M., Balibrea-Correa, J., Barbagallo, M., Barros, S., Bečvář, F., Beinrucker, C., Belloni, F., Berthoumieux, E., Billowes, J., Bosnar, D., Brugger, M., Caamaño, M., Calviño, F., Calviani, M., Cano-Ott, D., Cardella, R., Casanovas, A., Castelluccio, D.M., Cerutti, F., Chen, Y.H., Chiaveri, E., Colonna, N., Cortés-Giraldo, M.A., Cortés, G., Cosentino, L., Damone, L.A., Deo, K., Diakaki, M., Domingo-Pardo, C., Dressler, R., Dupont, E., Durán, I., Fernández-Domínguez, B., Ferrari, A., Ferreira, P., Finocchiaro, P., Frost, R.J.W., Furman, V., Ganesan, S., García, A.R., Gawlik, A., Gheorghe, I., Glodariu, T., Gonçalves, I.F., González, E., Goverdovski, A., Griesmayer, E., Guerrero, C., Göbel, K., Harada, H., Heftrich, T., Heinitz, S., Hernández-Prieto, A., Heyse, J., Jenkins, D.G., Jericha, E., Käppeler, F., Kadi, Y., Katabuchi, T., Kavrigin, P., Ketlerov, V., Khryachkov, V., Kimura, A., Kivel, N., Kokkoris, M., Krtička, M., Leal-Cidoncha, E., Lederer, C., Leeb, H., Lerendegui, J., Licata, M., Lonsdale, S.J., Losito, R., Macina, D., Marganiec, J., Martínez, T., Masi, A., Massimi, C., Mastinu, P., Mastromarco, M., Matteucci, F., Maugeri, E.A., Mazzone, A., Mendoza, E., Milazzo, P.M., Mingrone, F., Mirea, M., Montesano, S., Musumarra, A., Nolte, R., Oprea, A., Palomo-Pinto, F.R., Paradela, C., Patronis, N., Pavlik, A., Perkowski, J., Porras, I., Praena, J., Quesada, J.M., Rajeev, K., Rauscher, T., Reifarth, R., Riego-Perez, A., Robles, M., Rout, P., Radeck, D., Rubbia, C., Ryan, J.A., Sabaté-Gilarte, M., Saxena, A., Schillebeeckx, P., Schmidt, S., Schumann, D., Sedyshev, P., Smith, A.G., Stamatopoulos, A., Suryanarayana, S.V., Tagliente, G., Tain, J.L., Tarifeño-Saldivia, A., Tarrío, D., Tassan-Got, L., Tsinganis, A., Valenta, S., Vannini, G., Variale, V., Vaz, P., Ventura, A., Vlachoudis, V., Vlastou, R., Wallner, A., Warren, S., Weigand, M., Weiss, C., Wolf, C., Woods, P.J., Wright, T., Žugec, P., and Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Nuclear reaction, U-235, Nuclear transmutation, nTOF, CAPTURE CROSS-SECTION, Nuclear data, TOTAL ABSORPTION CALORIMETER, General Physics and Astronomy, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], COLLABORATION, 7. Clean energy, 01 natural sciences, PHYSICS, Nuclear physics, Physics and Astronomy (all), neutron, DESIGN, Radiation dosimetry, 0103 physical sciences, CERN, n_TOF, Nuclear Physics - Experiment, Neutron, 010306 general physics, nuclear data, n_TOF, CERN, Physics, Energies::Energia nuclear [Àrees temàtiques de la UPC], Neutrons, FRAGMENT ANGULAR-DISTRIBUTION, Large Hadron Collider, ntof, Física [Àrees temàtiques de la UPC], Cross section, 010308 nuclear & particles physics, cern, Experimental data, Radioactive waste, nuclear data, NATURAL SCIENCES. Physics, Radiació--Dosimetria, PRIRODNE ZNANOSTI. Fizika, Nuclear technology, CAPTURE CROSS-SECTION, TOTAL ABSORPTION CALORIMETER, FRAGMENT ANGULAR-DISTRIBUTION, NEUTRON, TH-232, U-235, C6D6, COLLABORATION, PHYSICS, DESIGN, NEUTRON, TH-232, C6D6
Abstract: International audience; Nuclear data in general, and neutron-induced reaction cross sections in particular, are important for a wide variety of research fields. They play a key role in the safety and criticality assessment of nuclear technology, not only for existing power reactors but also for radiation dosimetry, medical applications, the transmutation of nuclear waste, accelerator-driven systems, fuel cycle investigations and future reactor systems as in Generation IV. Applications of nuclear data are also related to research fields as the study of nuclear level densities and stellar nucleosynthesis. Simulations and calculations of nuclear technology applications largely rely on evaluated nuclear data libraries. The evaluations in these libraries are based both on experimental data and theoretical models. Experimental nuclear reaction data are compiled on a worldwide basis by the international network of Nuclear Reaction Data Centres (NRDC) in the EXFOR database. The EXFOR database forms an important link between nuclear data measurements and the evaluated data libraries. CERN's neutron time-of-flight facility n TOF has produced a considerable amount of experimental data since it has become fully operational with the start of the scientific measurement programme in 2001. While for a long period a single measurement station (EAR1) located at 185 m from the neutron production target was available, the construction of a second beam line at 20 m (EAR2) in 2014 has substantially increased the measurement capabilities of the facility. An outline of the experimental nuclear data activities at CERN's neutron time-of-flight facility n TOF will be presented.
Published: 2016

29. Posterior parietal cortex guides visual decisions in rats

Author: Anne K. Churchland, Angela M. Licata, David Raposo, John P. Sheppard, Michael B. Ryan, and Matthew T. Kaufman
Subjects: 0301 basic medicine, Auditory perception, Male, Visual perception, genetic structures, Nerve net, Decision Making, Posterior parietal cortex, Sensory system, Stimulus (physiology), Spike count, 03 medical and health sciences, 0302 clinical medicine, Reward, Parietal Lobe, Biological neural network, medicine, Animals, Rats, Long-Evans, Visual dominance, Research Articles, Communication, business.industry, General Neuroscience, Parietal lobe, Rats, Electrophysiology, Visual evidence, 030104 developmental biology, medicine.anatomical_structure, Auditory Perception, Visual Perception, Nerve Net, Psychology, business, Neuroscience, 030217 neurology & neurosurgery
Abstract: Neurons in putative decision-making structures can reflect both sensory and decision signals, making their causal role in decisions unclear. Here, we tested whether rat posterior parietal cortex (PPC) is causal for processing visual sensory signals or instead for accumulating evidence for decision alternatives. We disrupted PPC activity optogenetically during decision making and compared effects on decisions guided by auditory versus visual evidence. Deficits were largely restricted to visual decisions. To further test for visual dominance in PPC, we evaluated electrophysiological responses after individual sensory events and observed much larger response modulation after visual stimuli than auditory stimuli. Finally, we measured trial-to-trial spike count variability during stimulus presentation and decision formation. Variability decreased sharply, suggesting that the network is stabilized by inputs, unlike what would be expected if sensory signals were locally accumulated. Our findings suggest that PPC plays a causal role in processing visual signals that are accumulated elsewhere.SIGNIFICANCE STATEMENTDefining the neural circuits that support decision making bridges a gap between our understanding of simple sensorimotor reflexes and our understanding of truly complex behavior. However, identifying brain areas that play a causal role in decision making has proved challenging. We tested the causal role of a candidate component of decision circuits, the rat posterior parietal cortex (PPC). Our interpretation of the data benefited from our use of animals trained to make decisions guided by either visual or auditory evidence. Our results suggest that PPC plays a causal role specifically in visual decision making and may support sensory aspects of the decision, such as interpreting the visual signals so that evidence for a decision can be accumulated elsewhere.
Published: 2016
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30. Measurement of the 240Pu(n,f) cross-section at the CERN n TOF facility: First results from experimental area II (EAR-2)

Author: J. Marganiec, A. Kimura, E. Jericha, P. F. Mastinu, S. Montesano, Pedro G. Ferreira, J. A. Ryan, M. Mastromarco, Francesca Matteucci, Mario Barbagallo, S. V. Suryanarayana, D. Schumann, F. Mingrone, J. Andrzejewski, A. Pavlik, C. Domingo-Pardo, Carlo Rubbia, M. Kokkoris, A. Tsinganis, Anton Wallner, Variale, F. Calviño, Nicola Colonna, H. Leeb, J. Balibrea, T. Wright, M. Krtička, J. Perkowski, D. G. Jenkins, G. Tagliente, M. B. Gómez-Hornillos, C. Lederer, T. Martinez, Ketlerov, N. Patronis, F. Gunsing, A. K. Saxena, M. Licata, Bécares, E. Mendoza, Petar Žugec, Cristian Massimi, M. A. Cortés-Giraldo, F. Bečvář, O. Aberle, P. M. Milazzo, A. Stamatopoulos, A. Goverdovski, P. Schillebeeckx, I. Duran, Hideo Harada, S. Heinitz, L. Cosentino, J. Billowes, Alfredo Ferrari, F. R. Palomo-Pinto, S. Warren, C. Paradela, M. Bacak, S. Valenta, E. Dupont, R. Dressler, P. Kavrigin, Marco Calviani, A. Musumarra, Ioana Gheorghe, A. G. Smith, Ralf Nolte, M. S. Robles, T. Glodariu, B. Fernández-Domínguez, F. Käppeler, Furman, E. Griesmayer, Tanja Heftrich, L. A. Damone, C. Weiss, S. Schmidt, R. Vlastou, A. J. M. Plompen, M. Diakaki, A. Riego-Perez, Damir Bosnar, Y. Kadi, N. Kivel, E. González, R. Losito, E. Berthoumieux, Rene Reifarth, J. M. Quesada, L. Tassan-Got, Tatsuya Katabuchi, D. Macina, Carlos Guerrero, S. Barros, P. Vaz, L. Audouin, Alberto Ventura, E. Chiaveri, D. Cano-Ott, Khryachkov, A. Hernández-Prieto, J. I. Porras, M. Mirea, P. V. Sedyshev, Kathrin Göbel, Jan Heyse, J. L. Tain, Vlachoudis, P. Finocchiaro, Alberto Mengoni, G. Vannini, M. Caamaño, M. Weigand, Javier Praena, S. Lo Meo, F. Belloni, G. Cortes, R. J. W. Frost, F. Cerutti, J. Lerendegui-Marco, I. F. Gonçalves, K. Deo, Boccone, A. R. García, M. Brugger, C. Beinrucker, E. Leal-Cidoncha, Ariel Tarifeño-Saldivia, Thomas Rauscher, M. Sabaté-Gilarte, Universitat Politècnica de Catalunya. Departament de Física, Universitat Politècnica de Catalunya. ANT - Advanced Nuclear Technologies Research Group, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), n_TOF, Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Stamatopoulos, A., Tsinganis, A., Colonna, N., Vlastou, R., Kokkoris, M., Schillebeeckx, P., Plompen, A., Heyse, J., Ugec, P., Barbagallo, M., Calviani, M., Berthoumieux, E., Chiaveri, E., Aberle, O., Andrzejewski, J., Audouin, L., Bécares, V., Bacak, M., Balibrea, J., Barros, S., Bečvář, F., Beinrucker, C., Belloni, F., Billowes, J., Boccone, V., Bosnar, D., Brugger, M., Caamaño, M., Calviño, F., Cano-Ott, D., Cerutti, F., Cortés, G., Cortés-Giraldo, M.A., Cosentino, L., Damone, L.A., Deo, K., Diakaki, M., Domingo-Pardo, C., Dressler, R., Dupont, E., Durán, I., Fernández-Domínguez, B., Ferrari, A., Ferreira, P., Finocchiaro, P., Frost, R.J.W., Furman, V., Göbel, K., Gómez-Hornillos, M.B., García, A.R., Gheorghe, I., Glodariu, T., Gonçalves, I.F., González, E., Goverdovski, A., Griesmayer, E., Guerrero, C., Gunsing, F., Harada, H., Heftrich, T., Heinitz, S., Hernández-Prieto, A., Jenkins, D.G., Jericha, E., Käppeler, F., Kadi, Y., Katabuchi, T., Kavrigin, P., Ketlerov, V., Khryachkov, V., Kimura, A., Kivel, N., Krtička, M., Leal-Cidoncha, E., Lederer, C., Leeb, H., Lerendegui-Marco, J., Licata, M., Meo, S. Lo, Losito, R., Macina, D., Marganiec, J., Martínez, T., Massimi, C., Mastinu, P., Mastromarco, M., Matteucci, F., Mendoza, E., Mengoni, A., Milazzo, P.M., Mingrone, F., Mirea, M., Montesano, S., Musumarra, A., Nolte, R., Palomo-Pinto, F.R., Paradela, C., Patronis, N., Pavlik, A., Perkowski, J., Porras, J.I., Praena, J., Quesada, J.M., Rauscher, T., Reifarth, R., Riego-Perez, A., Robles, M., Rubbia, C., Ryan, J.A., Sabaté-Gilarte, M., Saxena, A., Schmidt, S., Schumann, D., Sedyshev, P., Smith, A.G., Suryanarayana, S.V., Tagliente, G., Tain, J.L., Tarifeño-Saldivia, A., Tassan-Got, L., Valenta, S., Vannini, G., Variale, V., Vaz, P., Ventura, A., Vlachoudis, V., Wallner, A., Warren, S., Weigand, M., Weiss, C., Wright, T., Universidad de Sevilla. Departamento de Física Atómica, Molecular y Nuclear, and Universidad de Sevilla. Departamento de Ingeniería Electrónica
Subjects: Nuclear fuel cycle, Fission, nTOF, QC1-999, Nuclear Theory, Neutron, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 01 natural sciences, 7. Clean energy, Nuclear physics, Physics and Astronomy (all), Neutron flux, 0103 physical sciences, CERN, Fusió nuclear, ddc:530, Nuclear Physics - Experiment, 010306 general physics, Nuclear Experiment, Physics, Energies::Energia nuclear [Àrees temàtiques de la UPC], Neutrons, Large Hadron Collider, Física [Àrees temàtiques de la UPC], Cross section, 010308 nuclear & particles physics, MicroMegas detector, Actinide, 13. Climate action, Nuclear fission, Nuclear fusion
Abstract: The accurate knowledge of the neutron-induced fission cross-sections of actinides and other isotopes involved in the nuclear fuel cycle is essential for the design of advanced nuclear systems, such as Generation-IV nuclear reactors. Such experimental data can also provide the necessary feedback for the adjustment of nuclear model parameters used in the evaluation process, resulting in the further development of nuclear fission models. In the present work, the 240Pu(n,f) cross-section was measured at CERN’s n TOF facility relative to the well-known 235U(n,f) cross section, over a wide range of neutron energies, from meV to almost MeV, using the time-of-flight technique and a set-up based on Micromegas detectors. This measurement was the first experiment to be performed at n TOF’s new experimental area (EAR-2), which offers a significantly higher neutron flux compared to the already existing experimental area (EAR-1). Preliminary results as well as the experimental procedure, including a description of the facility and the data handling and analysis, are presented., Support of the European Commission under the ANDES, ERINDA and CHANDA projects (7th Framework Programme).
Published: 2016

31. The 236U neutron capture cross-section measured at the n TOF CERN facility

Author: A. J. M. Plompen, Rene Reifarth, Stefan Schmidt, J. M. Quesada, L. Tassan-Got, C. Lampoudis, M. P. W. Chin, C. Domingo-Pardo, M. Sabaté-Gilarte, M. B. Gómez-Hornillos, Tanja Heftrich, V. Ketlerov, Christoph Langer, F. Roman, A. Riego-Perez, M. S. Robles, G. Vannini, G. Tagliente, C. Paradela, Srinivasan Ganesan, R. Sarmento, F. Cerutti, A. R. García, P. Vaz, D. Cano-Ott, R. Vlastou, M. Mirea, L. Audouin, M. J. Vermeulen, M. Diakaki, Alberto Ventura, E. Berthoumieux, I. Duran, W. Mondelaers, G. Giubrone, C. Lederer, Mario Barbagallo, M. Brugger, M. Kokkoris, A. Pavlik, P. V. Sedyshev, D. G. Jenkins, A. Manousos, Jeri Kroll, A. Goverdovski, M. Licata, V. Variale, A. Tsinganis, M. Mastromarco, F. Käppeler, Roberto Versaci, Damir Bosnar, F. Mingrone, M. A. Cortés-Giraldo, Y. Kadi, J. Andrzejewski, K. Fraval, Petar Žugec, Nicola Colonna, J. Marganiec, E. Leal-Cidoncha, Anton Wallner, G. Cortes, Vasilis Vlachoudis, C. Carrapiço, C. Eleftheriadis, A. K. Saxena, C. Weiss, S. Valenta, D. Tarrío, J. L. Tain, L. S. Leong, Arnaud Ferrari, Javier Praena, T. Ware, Thomas Rauscher, Alberto Mengoni, Marco Calviani, E. Chiaveri, J. Billowes, P. F. Mastinu, E. Griesmayer, D. Karadimos, Roberto Losito, Jan Heyse, S. Heinitz, P. Koehler, M. Krtička, T. Martinez, Carlos Guerrero, V. Furman, T. J. Wright, Ariel Tarifeño-Saldivia, A. Hernández-Prieto, J. Lerendegui-Marco, I. F. Gonçalves, T. Katabuchi, Fabio Belloni, F. Calviño, H. Leeb, P. Gurusamy, J. Perkowski, E. González, Mario Weigand, C. Rubbia, F. Gunsing, Cristian Massimi, F. Bečvář, E. Mendoza, Peter Schillebeeckx, N. Dzysiuk, V. Bécares, V. Khryachkov, P. M. Milazzo, S. Altstadt, E. Jericha, Dorothea Schumann, J. A. Ryan, Universitat Politècnica de Catalunya. Departament de Física, Universitat Politècnica de Catalunya. Departament de Física i Enginyeria Nuclear, Universitat Politècnica de Catalunya. ANT - Advanced Nuclear Technologies Research Group, Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, n_TOF, Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Universidad de Sevilla. Departamento de Física Atómica, Molecular y Nuclear, Mastromarco, M., Barbagallo, M., Vermeulen, M.J., Colonna, N., Altstadt, S., Andrzejewski, J., Audouin, L., Bécares, V., Bečvář, F., Belloni, F., Berthoumieux, E., Billowes, J., Bosnar, D., Brugger, M., Calviño, F., Calviani, M., Cano-Ott, D., Carrapiço, C., Cerutti, F., Chiaveri, E., Chin, M., Cortés, G., Cortés-Giraldo, M.A., Diakaki, M., Domingo-Pardo, C., Durán, I., Dzysiuk, N., Eleftheriadis, C., Ferrari, A., Fraval, K., Furman, V., Gómez-Hornillos, M.B., Ganesan, S., García, A.R., Giubrone, G., Gonçalves, I.F., González, E., Goverdovski, A., Griesmayer, E., Guerrero, C., Gunsing, F., Gurusamy, P., Heftrich, T., Heinitz, S., Hernández-Prieto, A., Heyse, J., Jenkins, D.G., Jericha, E., Käppeler, F., Kadi, Y., Karadimos, D., Katabuchi, T., Ketlerov, V., Khryachkov, V., Koehler, P., Kokkoris, M., Kroll, J., Krtička, M., Lampoudis, C., Langer, C., Leal-Cidoncha, E., Lederer, C., Leeb, H., Leong, L.S., Lerendegui-Marco, J., Licata, M., Losito, R., Manousos, A., Marganiec, J., Martínez, T., Massimi, C., Mastinu, P., Mendoza, E., Mengoni, A., Milazzo, P.M., Mingrone, F., Mirea, M., Mondelaers, W., Paradela, C., Pavlik, A., Perkowski, J., Plompen, A.J.M., Praena, J., Quesada, J.M., Rauscher, T., Reifarth, R., Riego-Perez, A., Robles, M., Roman, F., Rubbia, C., Ryan, J.A., Sabaté-Gilarte, M., Sarmento, R., Saxena, A., Schillebeeckx, P., Schmidt, S., Schumann, D., Sedyshev, P., Tagliente, G., Tain, J.L., Tarifeño-Saldivia, A., Tarrío, D., Tassan-Got, L., Tsinganis, A., Valenta, S., Vannini, G., Variale, V., Vaz, P., Ventura, A., Versaci, R., Vlachoudis, V., Vlastou, R., Wallner, A., Ware, T., Weigand, M., Weiss, C., Wright, T., and Ž Ugec, P.
Subjects: Nuclear reaction, nTOF, QC1-999, Neutron, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 01 natural sciences, 7. Clean energy, Nuclear physics, Physics and Astronomy (all), Cross section (physics), 0103 physical sciences, CERN, Neutron cross section, Nuclear Physics - Experiment, ddc:530, 010306 general physics, Absorption (electromagnetic radiation), Physics, Neutrons, Energies::Energia nuclear [Àrees temàtiques de la UPC], Isotope, Cross section, Reaccions nuclears, Física [Àrees temàtiques de la UPC], 010308 nuclear & particles physics, Resonance, Calorimeter, 13. Climate action, Nuclear reactions
Abstract: International audience; The $^{236}$U isotope plays an important role in nuclear systems, both for future and currently operating ones. The actual knowledge of the capture reaction of this isotope is satisfactory in the thermal region, but it is considered insufficient for Fast Reactor and ADS applications. For this reason the $^{236} \text{U}(n, \gamma)$ reaction cross-section has been measured for the first time in the whole energy region from thermal energy up to 1 MeV at the n_TOF facility with two different detection systems: an array of C$_6$D$_6$ detectors, employing the total energy deposited method, and a 4$\pi$ total absorption calorimeter (TAC), made of 40 BaF$_2$ crystals. The two n_TOF data sets agree with each other within the statistical uncertainty in the Resolved Resonance Region up to 800 eV, while sizable differences (up to ≃ 20%) are found relative to the current evaluated data libraries. Moreover two new resonances have been found in the n_TOF data. In the Unresolved Resonance Region up to 200 keV, the n_TOF results show a reasonable agreement with previous measurements and evaluated data.
Published: 2016
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32. Störungsbilder

Author: M. Ziegler, M. Licata, T. Besier, U. Ziegenhain, S. Wiegand-Grefe, and M. Schieche
Published: 2016

33. The Central Role of Community-Practicing Pediatricians in Contemporary Concussion Care: A Case Study of Children's Healthcare of Atlanta's Concussion Program

Author: Kim E. Ono, Susan Palasis, Larry B. Hall, Steve Kroll, Joshua J. Chern, Gerald H. Clark, Laura L. Hayes, Robert H. Wiskind, Elizabeth Hogan, Kimberly M. Speake, Andrew T. Reisner, Thomas G. Burns, Robert M. Licata, Joshua A. Vova, Shabnam Jain, Ton DeGrauw, David M Popoli, Brad C. Weselman, Blaire H. Holbrook, and David L. Marshall
Subjects: Program evaluation, medicine.medical_specialty, Georgia, Child Health Services, MEDLINE, Child health services, Pediatrics, Tertiary Care Centers, Concussion, Health care, medicine, Humans, Psychiatry, Child, Referral and Consultation, Brain Concussion, biology, business.industry, medicine.disease, biology.organism_classification, Hospitals, Pediatric, Atlanta, Family medicine, Pediatrics, Perinatology and Child Health, business, Program Evaluation
Published: 2015

34. A luciferase-based budding assay for Ebola virus

Author: Ronald N. Harty, Sarah E. McCarthy, and Jillian M. Licata
Subjects: Budding, Ebola virus, Viral matrix protein, biology, Viral Core Proteins, Virus Assembly, viruses, virus diseases, Filoviridae, Ebolavirus, biology.organism_classification, medicine.disease_cause, Virology, Virus, Cell Line, Nucleoproteins, VP40, Genes, Reporter, Luciferases, Firefly, Luminescent Measurements, medicine, Humans, Luciferase, Mononegavirales
Abstract: The VP40 matrix protein of Ebola virus (EBOV) is capable of budding from mammalian cells as a virus-like particle (VLP) and is the major protein involved in virus egress. A functional budding assay has been developed based upon this characteristic of VP40 to assess the contributions of VP40 sequences as well as host proteins to the budding process. This well-defined assay has been modified for potential use in a high-throughput format in which the detection and quantification of firefly luciferase protein in VLPs represents a direct measure of VP40 budding efficiency. Luciferase was found to be incorporated into budding VP40 VLPs. Furthermore, co-expression of EBOV glycoprotein (GP) enhances release of VLPs containing VP40 and luciferase. In contrast, when luciferase is co-expressed with a budding deficient mutant of VP40, luciferase levels in the VLP fraction decrease significantly. This assay represents a promising high-throughput approach to identify inhibitors of EBOV budding.
Published: 2006

35. Functional Analysis of Late-Budding Domain Activity Associated with the PSAP Motif within the Vesicular Stomatitis Virus M Protein

Author: Himangi R. Jayakar, Ronald N. Harty, Jillian M. Licata, Peter Bell, Takashi Irie, and Michael A. Whitt
Subjects: Gene Expression Regulation, Viral, viruses, Amino Acid Motifs, Molecular Sequence Data, Immunology, Mutant, Viral Plaque Assay, Vesicular stomatitis Indiana virus, Microbiology, Virus, Cell Line, Viral Matrix Proteins, Cricetinae, Virology, Animals, Amino Acid Sequence, Mononegavirales, Recombination, Genetic, Viral matrix protein, biology, Rhabdoviridae, biology.organism_classification, Molecular biology, Reverse genetics, Virus-Cell Interactions, Microscopy, Electron, Vesicular stomatitis virus, Insect Science, Mutation
Abstract: A PPPY motif within the M protein of vesicular stomatitis virus (VSV) functions as a late-budding domain (L-domain); however, L-domain activity has yet to be associated with a downstream PSAP motif. VSV recombinants with mutations in the PPPY and/or PSAP motif were recovered by reverse genetics and examined for growth kinetics, plaque size, and budding efficiency by electron microscopy. Results indicate that unlike the PPPY motif, the PSAP motif alone does not possess L-domain activity. Finally, the insertion of the human immunodeficiency virus type 1 p6 L-domain and flanking sequences into the PSAP region of M protein rescued budding of a PPPY mutant of VSV to wild-type levels.
Published: 2004

36. Budding of PPxY-Containing Rhabdoviruses Is Not Dependent on Host Proteins TGS101 and VPS4A

Author: Ronald N. Harty, Jillian M. Licata, Takashi Irie, James P. McGettigan, and Matthias J. Schnell
Subjects: Recombinant Fusion Proteins, viruses, Amino Acid Motifs, Immunology, macromolecular substances, medicine.disease_cause, Microbiology, Vesicular stomatitis Indiana virus, Virus, Cell Line, Viral Matrix Proteins, VP40, Virology, medicine, Animals, Humans, TSG101, Adenosine Triphosphatases, Budding, Viral matrix protein, Ebola virus, Endosomal Sorting Complexes Required for Transport, biology, Viral Core Proteins, Virus Assembly, Virion, VPS4A, Ebolavirus, biology.organism_classification, Virus-Cell Interactions, DNA-Binding Proteins, Nucleoproteins, Vesicular stomatitis virus, Insect Science, COS Cells, Transcription Factors
Abstract: Viral matrix proteins of several enveloped RNA viruses play important roles in virus assembly and budding and are by themselves able to bud from the cell surface in the form of lipid-enveloped, virus-like particles (VLPs). Three motifs (PT/SAP, PPxY, and YxxL) have been identified as late budding domains (L-domains) responsible for efficient budding. L-domains can functionally interact with cellular proteins involved in vacuolar sorting (VPS4A and TSG101) and endocytic pathways (Nedd4), suggesting involvement of these pathways in virus budding. Ebola virus VP40 has overlapping PTAP and PPEY motifs, which can functionally interact with TSG101 and Nedd4, respectively. As for vesicular stomatitis virus (VSV), a PPPY motif within M protein can interact with Nedd4. In addition, M protein has a PSAP sequence downstream of the PPPY motif, but the function of PSAP in budding is not clear. In this study, we compared L-domain functions between Ebola virus and VSV by constructing a chimeric M protein (M40), in which the PPPY motif of VSV M is replaced by the L domains of VP40. The budding efficiency of M40 was 10-fold higher than that of wild-type (wt) M protein. Overexpression of a dominant negative mutant of VPS4A or depletion of cellular TSG101 reduced the budding of only M40-containing VLPs but not that of wt M VLPs or live VSV. These findings suggest that the PSAP motif of M protein is not critical for budding and that there are fundamental differences between PTAP-containing viruses (Ebola virus and human immunodeficiency virus type 1) and PPPY-containing viruses (VSV and rabies virus) regarding their dependence on specific host factors for efficient budding.
Published: 2004

37. RHABDOVIRUSES AND APOPTOSIS

Author: Jillian M. Licata and Ronald N. Harty
Subjects: Host (biology), viruses, Immunology, Rabies virus, Apoptosis, Viremia, Biology, medicine.disease, medicine.disease_cause, biology.organism_classification, Virology, Vesicular stomatitis Indiana virus, Virus, Viral Matrix Proteins, Viral Proteins, Vesicular stomatitis virus, Rhabdoviridae Infections, Veterinary virology, medicine, Animals, Immunology and Allergy, sense organs, Rhabdoviridae, Stomatitis
Abstract: Viral-induced apoptosis is recognized as a common method utilized by viruses to overcome the host. Recent evidence indicates that infection by rhabdoviruses such as vesicular stomatitis virus (VSV), spring viremia of carp virus (SVCV), and rabies virus results in apoptotic cell death. Similar morphological changes and host cell proteins are induced in cells infected with these different viruses; however, the viral proteins responsible for these changes vary. In addition, the molecular mechanism(s) utilized by these viruses to induce apoptosis are on the brink of discovery. This article serves to summarize our current understanding of the apoptotic process during rhabdovirus infection and to illustrate forthcoming areas of study in the field
Published: 2003

38. The measurement programme at the neutron time-of-flight facility n_TOF at CERN

Author: M. Krtička, T. Martinez, M. Mastromarco, M. Licata, Y. H. Chen, J. Marganiec, E. Chiaveri, P. F. Mastinu, I. Porras, F. Bečvář, E. Leal-Cidoncha, Anton Wallner, C. Wolf, P. Kavrigin, C. Rubbia, Rene Reifarth, Stefan Schmidt, E. Mendoza, G. Vannini, Ralf Nolte, A. Gawlik, N. Patronis, A. K. Saxena, Peter Schillebeeckx, A. S. Brown, P. C. Rout, F. Mingrone, C. Lederer, J. M. Quesada, Arnaud Ferrari, L. Tassan-Got, Thomas Rauscher, Javier Praena, S. Lo Meo, A. Goverdovski, G. Tagliente, F. R. Palomo-Pinto, D. M. Castelluccio, A. Kimura, Srinivasan Ganesan, J. Andrzejewski, E. Griesmayer, Alberto Mengoni, C. Paradela, D. Macina, Carlos Guerrero, M. Caamaño, S. Heinitz, J. Billowes, O. Aberle, V. Khryachkov, J. L. Tain, L. Audouin, P. M. Milazzo, M. S. Robles, Tatsuya Katabuchi, D. Cano-Ott, S. Montesano, A. R. García, V. Bécares, Ariel Tarifeño-Saldivia, S. J. Lonsdale, Mario Barbagallo, Deniz Kurtulgil, P. V. Sedyshev, Emilio Andrea Maugeri, S. V. Suryanarayana, Niko Kivel, F. Cerutti, M. Kokkoris, L. Cosentino, S. Barros, I. Duran, M. Brugger, E. Jericha, G. Cortes, A. Musumarra, C. Beinrucker, Paolo Finocchiaro, D. Tarrío, K. Rajeev, Dorothea Schumann, J. A. Ryan, K. Deo, Simone Gilardoni, A. Hernández-Prieto, Francesca Matteucci, V. Ketlerov, E. González, R. J. W. Frost, A. Casanovas, M. Diakaki, R. Cardella, I. F. Gonçalves, Alexandru Negret, J. Balibrea-Correa, B. Fernández-Domínguez, F. Käppeler, C. Weiss, Tanja Heftrich, A. Oprea, P. Vaz, S. Warren, A. Riego-Perez, Kathrin Göbel, Damir Bosnar, Y. Kadi, L. A. Damone, Alberto Ventura, Jan Heyse, A. Stamatopoulos, S. Valenta, V. Variale, Marco Calviani, A. Pavlik, A. Kalamara, A. G. Smith, C. Domingo-Pardo, Philip Woods, Fabio Belloni, Hideo Harada, M. Sabaté-Gilarte, F. Gunsing, Cristian Massimi, A. Masi, D. G. Jenkins, M. Mirea, F. Calviño, H. Leeb, M. A. Cortés-Giraldo, J. Perkowski, Pedro G. Ferreira, Mario Weigand, R. Vlastou, D. Radeck, E. Berthoumieux, N. V. Sosnin, Annamaria Mazzone, Petar Žugec, Rugard Dressler, V. Furman, T. J. Wright, A. Tsinganis, Nicola Colonna, Vasilis Vlachoudis, M. Bacak, T. Glodariu, Roberto Losito, E. Dupont, Ioana Gheorghe, J. Lerendegui, Mengoni, A., Lo Meo, S., Castelluccio, D. M., Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), n_TOF, Universidad de Sevilla. Departamento de Física Atómica, Molecular y Nuclear, Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Universitat Politècnica de Catalunya. Departament de Física, Universitat Politècnica de Catalunya. Institut de Tècniques Energètiques, Universitat Politècnica de Catalunya. ANT - Advanced Nuclear Technologies Research Group, Gunsing, F., Aberle, O., Andrzejewski, J., Audouin, L., Bécares, V., Bacak, M., Balibrea-Correa, J., Barbagallo, M., Barros, S., Bečvář, F., Beinrucker, C., Belloni, F., Berthoumieux, E., Billowes, J., Bosnar, D., Brown, A., Brugger, M., Caamaño, M., Calviño, F., Calviani, M., Cano-Ott, D., Cardella, R., Casanovas, A., Castelluccio, D.M., Cerutti, F., Chen, Y.H., Chiaveri, E., Colonna, N., Cortés-Giraldo, M.A., Cortés, G., Cosentino, L., Damone, L.A., Deo, K., Diakaki, M., Domingo-Pardo, C., Dressler, R., Dupont, E., Durán, I., Fernández-Domínguez, B., Ferrari, A., Ferreira, P., Finocchiaro, P., Frost, R.J.W., Furman, V., Ganesan, S., García, A.R., Gawlik, A., Gheorghe, I., Gilardoni, S., Glodariu, T., Gonçalves, I.F., González, E., Goverdovski, A., Griesmayer, E., Guerrero, C., Göbel, K., Harada, H., Heftrich, T., Heinitz, S., Hernández-Prieto, A., Heyse, J., Jenkins, D.G., Jericha, E., Käppeler, F., Kadi, Y., Kalamara, A., Katabuchi, T., Kavrigin, P., Ketlerov, V., Khryachkov, V., Kimura, A., Kivel, N., Kokkoris, M., Krtička, M., Kurtulgil, D., Leal-Cidoncha, E., Lederer, C., Leeb, H., Lerendegui, J., Licata, M., Meo, S. Lo, Lonsdale, S.J., Losito, R., Macina, D., Marganiec, J., Martínez, T., Masi, A., Massimi, C., Mastinu, P., Mastromarco, M., Matteucci, F., Maugeri, E.A., Mazzone, A., Mendoza, E., Milazzo, P.M., Mingrone, F., Mirea, M., Montesano, S., Musumarra, A., Nolte, R., Negret, A., Oprea, A., Palomo-Pinto, F.R., Paradela, C., Patronis, N., Pavlik, A., Perkowski, J., Porras, I., Praena, J., Quesada, J.M., Radeck, D., Rajeev, K., Rauscher, T., Reifarth, R., Riego-Perez, A., Robles, M., Rout, P., Rubbia, C., Ryan, J.A., Sabaté-Gilarte, M., Saxena, A., Schillebeeckx, P., Schmidt, S., Schumann, D., Sedyshev, P., Smith, A.G., Sosnin, N.V., Stamatopoulos, A., Suryanarayana, S.V., Tagliente, G., Tain, J.L., Tarifeño-Saldivia, A., Tarrío, D., Tassan-Got, L., Tsinganis, A., Valenta, S., Vannini, G., Variale, V., Vaz, P., Ventura, A., Vlachoudis, V., Vlastou, R., Wallner, A., Warren, S., Weigand, M., Weiss, C., Wolf, C., Woods, P.J., Wright, T., and Ž Ugec, P.
Subjects: Engineering, Nuclear transmutation, QC1-999, Nuclear engineering, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 7. Clean energy, 01 natural sciences, Nuclear physics, Physics and Astronomy (all), 0103 physical sciences, Física::Electromagnetisme [Àrees temàtiques de la UPC], ddc:530, Nuclear Physics - Experiment, Neutron, 010306 general physics, Neutrons, Energies::Energia nuclear [Àrees temàtiques de la UPC], Large Hadron Collider, 010308 nuclear & particles physics, business.industry, Physics, Nuclear data, Radioactive waste, Nuclear technology, Beamline, Criticality, business
Abstract: Neutron-induced reaction cross sections are important for a wide variety of research fields ranging from the study of nuclear level densities, nucleosynthesis to applications of nuclear technology like design, and criticality and safety assessment of existing and future nuclear reactors, radiation dosimetry, medical applications, nuclear waste transmutation, accelerator-driven systems and fuel cycle investigations. Simulations and calculations of nuclear technology applications largely rely on evaluated nuclear data libraries. The evaluations in these libraries are based both on experimental data and theoretical models. CERN’s neutron time-of-flight facility n TOF has produced a considerable amount of experimental data since it has become fully operational with the start of its scientific measurement programme in 2001. While for a long period a single measurement station (EAR1) located at 185 m from the neutron production target was available, the construction of a second beam line at 20 m (EAR2) in 2014 has substantially increased the measurement capabilities of the facility. An outline of the experimental nuclear data activities at n TOF will be presented.
Published: 2017

39. Post-tenure Review: National Trends, Questions and Concerns

Author: Christine M. Licata and Joseph C. Morreale
Subjects: Higher education, Management science, business.industry, Political science, Evaluation methods, Policy initiatives, National trends, Faculty development, Public relations, business, Education, Personnel policy
Abstract: Evaluation and development of tenured faculty, commonly referred to as post-tenure review, is one of the most controversial policy initiatives of this decade. Reaction to these policies has been mixed. The authors discuss the evolution of such policies, review current practices, describe common approaches, and summarize unifying principles that lead to successful implementation. Lingering questions regarding impact, outcomes, cost, and benefit are explored.
Published: 1999

40. Modeling the Environmental Impact of Aquacultural Facilities - A Foundation for Future Management

Author: Dale M. Licata
Subjects: Aquaculture, modeling, Electronic computers. Computer science, QA75.5-76.95
Abstract: A numerical model for computing the oxygen consumption and leakage of nutrients and organic matter from an aquacultural facility has been implemented. It is based upon the energy equation for fish and accounts for metabolism and growth over a range of temperatures and fish weight classes.
Published: 1986
Full Text: View/download PDF

41. Role of diagnostic imaging in evaluation of the dental implant patient

Author: A M DelBalso, M Licata, and F G Greiner
Subjects: business.industry, Radiography, medicine.medical_treatment, Dental Implantation, Endosseous, food and beverages, Dentistry, Mandible, Fixture, Osseointegration, Maxilla, Radiography, Dental, Alveolar ridge, Medical imaging, Humans, Medicine, Radiology, Nuclear Medicine and imaging, Implant, business, Dental implant, Abutment (dentistry)
Abstract: Dental implants have become an accepted form of permanent tooth replacement. Nearly all implants currently being placed are of the osseointegrated type. These typically consist of three parts: a fixture, an abutment, and a screw or threaded rod. The fixture, usually composed of titanium, can be placed in either a surgically created site in the alveolar ridge or a fresh extraction socket. Diagnostic imaging can play an important role in evaluating patients with such implants. Useful imaging studies include plain panoramic radiography, computed tomography, and computer-reformatted cross-sectional, panoramic, and three-dimensional imaging. Advanced imaging studies can be used to determine the suitability of implant placement, appropriate sites for implant placement, the size of the implant that can be placed, and the need for preimplantation ridge surgery. Postoperatively, advanced imaging studies can show failure of an endosseous implant to osseointegrate, improper placement of an implant, and violation of important structures.
Published: 1994

42. Genetics of addiction in legal medicine and forensic investigation: SNPs variations associated with nicotine and cannabis dependence

Author: Giovanni Beduschi, D. Vandelli, Susi Pelotti, Gianmarco Ferri, M. Licata, Milena Alù, L. Picchini, Beatrice Corradini, G. Ferri, M. Alù, B. Corradini, L. Picchini, M. Licata, S. Pelotti, D. Vandelli, and G. Beduschi
Subjects: Drug, Genetics, medicine.medical_specialty, biology, business.industry, Addiction, media_common.quotation_subject, Medical jurisprudence, SNP, Heritability, biology.organism_classification, Pathology and Forensic Medicine, Nicotine, FORENSIC GENETICS, DRUG ADDICTION, DEPENDENCE, Epidemiology, medicine, Cannabis, Cannabis Dependence, business, media_common, medicine.drug
Abstract: Substance addiction is a complex chronic brain disorder, characterized by neurobiological changes leading to compulsive drug seeking and taking. Although environmental factors contribute to drug addiction, evidence showed that genetic factors with multiple genes also play a significant role. Cannabis and tobacco result as the most common widely abused substances. Epidemiological studies have strongly implicated genetics in nicotine and marijuana consuming and vulnerability to subsequent dependence, estimating the range of heritability from 34% to 78% for cannabis and approximately from 50% to 70% for nicotine. Furthermore, varying aspects of impulsive personality and principal psychiatric disorders co-occur with tobacco and cannabis dependence status. We evaluate the possibility of identifying an individual's risk probability to become an addict, based on a genotype analysis and the different possible applications in legal medicine and forensic genetics.
Published: 2009

43. FACULTY LEADERS' RESPONSES TO POST‐TENURE EVALUATION PRACTICES

Author: Christine M. Licata and Hans A. Andrews
Subjects: Medical education, North central, media_common.quotation_subject, General Medicine, Plan (drawing), Formative assessment, Summative assessment, Pedagogy, Evaluation methods, Institution, Suspect, Faculty development, Psychology, media_common
Abstract: Faculty leaders (union head or faculty association head) from the 305 member colleges in the 19‐state North Central Region were surveyed to determine the status and effectiveness of post‐tenure evaluation within each institution. Responses indicate that there is overwhelming support for the need to review tenured faculty for purposes of development and improvement. However, the effectiveness of current systems in accomplishing this goal is suspect. The major reasons cited for ineffectiveness include the inability of the evaluation to tie directly to faculty development and the lack of credible mechanisms to reward meritorious teaching and deal effectively with substandard teaching. Suggestions for improvement include development of an evaluation plan which, over time, can join formative and summative results.
Published: 1992

44. Administrative perceptions of existing evaluation systems

Author: Christine M. Licata and Hans A. Andrews
Subjects: Medical education, Evaluation system, Higher education, business.industry, media_common.quotation_subject, Education, Perception, Human resource management, Pedagogy, Evaluation methods, Faculty development, business, Psychology, media_common
Abstract: This research study focused on a number of issues related to the status and effectiveness of post-tenure evaluation practices within the two-year college sector.
Published: 1991

45. Metformin-induced lactic acidosis in a type 2 diabetic patient with acute renal failure

Author: A, Di Grande, F, Vancheri, V, Giustolisi, C, Giuffrida, G, Narbone, M, Licata, C, Le Moli, S, Riccobene, A, Burgio, S, Bartolotta, F, Nigro, and V, Cannone
Subjects: Diarrhea, Dehydration, Diabetes Mellitus, Type 2, Humans, Hypoglycemic Agents, Acidosis, Lactic, Female, Disease Susceptibility, Acute Kidney Injury, Emergencies, Combined Modality Therapy, Metformin, Aged
Abstract: Metformin is a biguanide commonly used in type 2 diabetes mellitus (DM). Lactic acidosis, a potentially life-threatening metabolic disorder, may be due to a number of different causes, including metformin therapy. We present a case of a severe metformin-induced lactic acidosis in a patient with type 2 DM, admitted to the emergency department with a history of dehydration due to diarrhoea and complicated by acute renal failure. Patient complained malaise and severe weakness and was tachypneic (Kussmaul's respiration), agitated and confused, with a Glasgow Coma Scale score of 13/15. Heart rate was 75 b/min and blood pressure 110/80 mmHg. The pH was 6.87, HCO3- 3 mmol/l, lactate 15 mmol/l, potassium 6.9 mEq/l. The renal function was markedly impaired with a creatinine of 9.75 mg/dl, and pancreatic enzymes, amylase and lipase, were also increased in absence of abdominal pain. Patient was treated with intravenous fluids, bicarbonate infusion and haemodialysis with bicarbonate buffered replacement fluid. Clinical conditions improved rapidly, with a progressive normalization of the acid-base balance and the other laboratory data. Authors discuss the pathophysiologic mechanisms of these alterations with particular regard to the role played by metformin as potential cause of lactic acidosis.
Published: 2008

46. The Status of Tenured Faculty Evaluation in the Community College

Author: Christine M. Licata and Hans A. Andrews
Subjects: Medical education, 0502 economics and business, 05 social sciences, Evaluation methods, 050301 education, Sociology, 050207 economics, Community college, 0503 education, Education
Published: 1990

47. Permeabilization of the plasma membrane by Ebola virus GP2

Author: Jason Paragas, Jillian M. Licata, Ronald N. Harty, and Ziying Han
Subjects: Cell Membrane Permeability, Membrane permeability, Protein subunit, Recombinant Fusion Proteins, Cell, DNA Mutational Analysis, Molecular Sequence Data, Biology, Viral Nonstructural Proteins, medicine.disease_cause, Virus, VP40, Viral Envelope Proteins, Virology, Chlorocebus aethiops, Genetics, medicine, Animals, Humans, Amino Acid Sequence, Molecular Biology, Cells, Cultured, chemistry.chemical_classification, Ebola virus, Brefeldin A, Dose-Response Relationship, Drug, Cell Membrane, General Medicine, Transmembrane protein, Cell biology, Anti-Bacterial Agents, Protein Structure, Tertiary, medicine.anatomical_structure, chemistry, COS Cells, Hygromycin B, Glycoprotein
Abstract: The glycoprotein (GP) of Ebola virus (EBOV) is a multifunctional protein known to play a role in virus attachment and entry, cell rounding and cytotoxicity, down-regulation of host surface proteins, and enhancement of virus assembly and budding. EBOV GP is synthesized as a precursor which is subsequently cleaved to yield two disulfide-linked subunits: GP1 (surface-exposed [SU] subunit) and GP2 (membrane-anchored [TM] subunit). We sought to determine the effect of membrane-anchored GP2 protein expression on the integrity of host cell lipid membranes. Our findings indicated that: (i) expression of GP2 enhanced membrane permeability to hygromycin-B (hyg-B), (ii) the transmembrane (TM) domain of GP2 was essential for enhanced membrane permeability, (iii) amino acids (aa) 667ALF669 within the TM region of GP2 were important for enhanced membrane permeability, and (iv) EBOV infected cells were more permeable to hyg-B than mock infected cells. Together, these data suggest that the TM region of GP2 modifies the permeability of the plasma membrane. These findings may have important implications for GP-induced cell damage and pathogenesis of EBOV infection.
Published: 2005

48. Antiviral Strategies for Ebola Virus

Author: Jillian M. Licata and Ronald N. Harty
Subjects: Ebola virus, Biology, medicine.disease_cause, Virology, Microbiology, Marburg virus, Pathogenesis, VP40, Viral replication, medicine, biology.protein, Replicon, Antibody, Lipid raft
Published: 2005

49. Contribution of Ebola Virus Glycoprotein, Nucleoprotein, and VP24 to Budding of VP40 Virus-Like Particles

Author: Reed F. Johnson, Jillian M. Licata, Ziying Han, and Ronald N. Harty
Subjects: Gene Expression Regulation, Viral, viruses, Immunology, Filoviridae, medicine.disease_cause, Microbiology, complex mixtures, Virus, Cell Line, Viral Proteins, VP40, Virus-like particle, Virology, medicine, Animals, Humans, Mononegavirales, Glycoproteins, Ebola virus, Viral matrix protein, biology, Structure and Assembly, Viral Core Proteins, Virion, virus diseases, biology.organism_classification, Ebolavirus, Nucleoprotein, Nucleoproteins, Insect Science, COS Cells
Abstract: The VP40 matrix protein of Ebola virus buds from cells in the form of virus-like particles (VLPs) and plays a central role in virus assembly and budding. In this study, we utilized a functional budding assay and cotransfection experiments to examine the contributions of the glycoprotein (GP), nucleoprotein (NP), and VP24 of Ebola virus in facilitating release of VP40 VLPs. We demonstrate that VP24 alone does not affect VP40 VLP release, whereas NP and GP enhance release of VP40 VLPs, individually and to a greater degree in concert. We demonstrate further the following: (i) VP40 L domains are not required for GP-mediated enhancement of budding; (ii) the membrane-bound form of GP is necessary for enhancement of VP40 VLP release; (iii) NP appears to physically interact with VP40 as judged by detection of NP in VP40-containing VLPs; and (iv) the C-terminal 50 amino acids of NP may be important for interacting with and enhancing release of VP40 VLPs. These findings provide a more complete understanding of the role of VP40 and additional Ebola virus proteins during budding.
Published: 2004

50. Budding of PPxY-Containing Rhabdoviruses Is Not Dependent on Host Proteins TSG101 and VPS4A

Author: Takashi Irie, Jillian M. Licata, James P. McGettigan, Matthias J. Schnell, and Ronald N. Harty
Subjects: Errata, Virology, Insect Science, Immunology, Microbiology
Published: 2004

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