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6 results on '"M. Klebes"'

1. Effects of tissue-tolerable plasma on psoriasis vulgaris treatment compared to conventional local treatment: A pilot study

Author

Juergen Lademann, Alexa Patzelt, Axel Kramer, Sandra Philipp, K.-D. Weltmann, Bernhard Lange-Asschenfeldt, Claas Ulrich, Wolfram Sterry, Franziska Kluschke, M. Klebes, and M. Ulmer

Subjects
medicine.medical_specialty, Dermatology, respiratory system, medicine.disease, Gastroenterology, chemistry.chemical_compound, Bacterial colonization, chemistry, hemic and lymphatic diseases, Internal medicine, Psoriasis, Dithranol, medicine, heterocyclic compounds, Surgery, Skin lesion, therapeutics, human activities, Infiltration (medical), Salicylic acid, medicine.drug
Abstract

The effect of tissue-tolerable plasma (TTP) on inflammatory diseases such as psoriasis was investigated. Three plaques of six psoriatic patients were subjected to different treatments (A: TTP, brine baths (BB)+5% salicylic acid ointment (SAO); B: BB+SAO; C: BB, UV irradiation, SAO+dithranol). While redness and infiltration was reduced in groups A and C, scaling was reduced in group C. TTP temporarily reduced the bacterial colonization on the skin lesions. In summary, the treatment of psoriatic plaques with TTP showed no significant advantage over conventional therapies.

Published
2014
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2. Risk assessment of the application of tissue-tolerable plasma on human skin

Author

Axel Kramer, Alexa Patzelt, Olaf Lademann, Franziska Kluschke, Bernhard Lange-Asschenfeldt, Juergen Lademann, K.-D. Weltmann, C. Ulrich, Heike Richter, and M. Klebes

Subjects
medicine.medical_specialty, Chemistry, medicine.drug_class, Urology, Plasma jet, Atmospheric-pressure plasma, Human skin, Dermatology, Plasma, respiratory system, Surgery, Antiseptic, In vivo, medicine, Porcine skin, Risk assessment
Abstract

The results of the risk assessment of the tissue-tolerable plasma (TTP) jet kINPen med ® and first results of pilot clinical studies are presented. Producing an atmospheric pressure plasma, this plasma jet entails no risk for humans in terms of temperature increase, UV radiation or free radical formation by the plasma. The antiseptic efficacy in vitro on porcine skin and in vivo on human skin was compared to that of octenidine. TTP could significantly reduce the bacterial load in comparison to untreated skin. However, the slightly reduced antiseptic properties of TTP are attributed to the current parameter set-up and technical limitations.

Published
2013
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5. Dapsone as Second-Line Treatment for Cutaneous Lupus Erythematosus? A Retrospective Analysis of 34 Patients and a Review of the Literature.

Author

Klebes M, Wutte N, and Aberer E

Subjects
Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Retrospective Studies, Antimalarials therapeutic use, Dapsone therapeutic use, Lupus Erythematosus, Cutaneous drug therapy
Abstract

Background: A variety of therapeutic options have been reported for cutaneous lupus erythematosus (CLE); one of these is dapsone. However, no high priority has been given to this drug., Objective: To determine whether dapsone is an effective and safe treatment alternative in patients with LE., Methods: We reviewed the literature and analyzed retrospectively 34 CLE patients who were treated with dapsone as monotherapy or combined with antimalarials. We assessed the course of the disease under treatment, response, concomitant treatment and side effects., Results: Six patients went into remission, 14 patients improved, and in 6 patients disease remained constant during the observation period. Dapsone was discontinued in 9 patients: in 4 due to reversible side effects and in 5 patients due to poor efficacy., Conclusion: Our data confirm that dapsone with/without antimalarials is effective in more than 50% of patients with CLE and could be used as second-line therapy for CLE., (© 2015 S. Karger AG, Basel.)

Published
2016
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6. Combined antibacterial effects of tissue-tolerable plasma and a modern conventional liquid antiseptic on chronic wound treatment.

Author

Klebes M, Ulrich C, Kluschke F, Patzelt A, Vandersee S, Richter H, Bob A, von Hutten J, Krediet JT, Kramer A, Lademann J, and Lange-Asschenfeld B

Subjects
Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents adverse effects, Anti-Bacterial Agents therapeutic use, Anti-Infective Agents, Local adverse effects, Anti-Infective Agents, Local therapeutic use, Drug Interactions, Exudates and Transudates drug effects, Female, Humans, Leg Ulcer drug therapy, Leg Ulcer microbiology, Leg Ulcer pathology, Leg Ulcer physiopathology, Male, Middle Aged, Pain chemically induced, Plasma Gases adverse effects, Plasma Gases therapeutic use, Anti-Bacterial Agents pharmacology, Anti-Infective Agents, Local pharmacology, Plasma Gases pharmacology, Wound Healing drug effects
Abstract

Potential antimicrobial effects of sequential applications of tissue-tolerable plasma (TTP) and the conventional liquid antiseptic octenidine dihydrochloride (ODC) were investigated. 34 patients with chronic leg ulcers were treated with TTP, ODC or a combination of both. The bacterial colonization was measured semi-quantitatively before and immediately after treatment and changes in the microbial strains' compositions before and after antiseptic treatments were analyzed. All antiseptic procedures reduced the bacterial counts significantly. The sequential application of TTP and ODC displayed the highest antimicrobial efficacy. Me combined use of TTP and conventional antiseptics might represent the most efficient strategy for antiseptic treatment of chronic wounds., (© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2015
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