Search

Due to requirement of unique architectural appearance of building, the regularity in plan, mass and stiffness may get disturbed and may lead to development of torsion in the structure. The two most significant aspects of new structures are form and function, which are growing more sophisticated as elements of equally sophisticated "systems" that we live in. Both the shape and the structural system must be sound in order for the construction to be both aesthetically pleasing and functionally successful. Nowadays, it is usual to see structures that are irregularly shaped or sculptural in nature. The irregular shape building differs from regular building in terms of shape, structure, reliability, economy and aesthetic appearance. The study focuses on design and load analysis of an irregular steel structure which is in the shape of a ship. The design and analysis is performed in STAAD PRO software.

The present study investigated on the effect of zinc solubilizing microorganisms on microbial population in soil of pigeonpea [Cajanus cajan] on vertisol. The field experiment was carried out in experimental field of department of soil science and agricultural chemistry at College of Agriculture, Vasantrao Naik Marathwada Krishi Vidyapeeth, Parbhani during kharif season 2018-19 and 2019-20 in factorial randomized block design with 3 replications. The pigeonpea variety BDN-711 was used for study. The studies revealed that, at flowering, pod formation and at harvesting stage significantly the maximum value of soil bacteria were recorded in Pseudomonas striata along with 30 kg ZnSO4 ha-1 treated plots (64.00, 74.00 and 57.90 CFU x 10-7 g-1 of soil) during 2018-19; (76.11, 87.44 and 68.67 CFU x 10-7 g-1 of soil) during 2019-20, respectively. At flowering, pod formation and at harvesting stage significantly the highest fungal population was noticed in treatment receving Trichoderma viride alongwith ZnSO4 30 kg ha-1 (9.67, 8.00 and 8.33 CFU x 10-4 g-1 of soil) during 2018-19; (10.67, 9.78 and 8.89 CFU x 10-4 g-1 of soil) during 2019-20, respectively. Also, at flowering, pod formation and at harvesting stage the actinomycetes population was found to be increased with the application of different zinc solubilizing cultures which ranged from (27.28 to 32.64, 30.45 to 38.83 and 26.86 to 30.47 CFU X 10-5g-1 of soil) during 2018-19; (31.64 to 38.67, 34.67 to 43.61 and 28.36 to 34.81 CFU X 10-5g-1 of soil) during 2019-20.

Buspirone is a psychotropic drug which belongs to the class of compounds known as azaspirodecanediones. Buspirone used primarily as an anxiolytic. It specifically used for generalized anxiety disorder. As an anxiolytic drug buspirone is as potent as benzodiazepines, but it does not cause the adverse side effects, for example sedation, anti-convulsion or muscle relaxation. Buspirone was first approved in 1986 by USFDA. Therefore, the main objective of this analysis of Buspirone in pharmaceutical and biological formulation is in both qualitative and quantitative terms. In this review article, we have summarized UV/Vis spectroscopy, high- performance liquid chromatography (HPLC), High-performance thin-layer chromatography (HPTLC), Liquid chromatography-mass spectroscopy-mass spectroscopy (LC-MS/MS) etc. based methods for estimation of Buspirone. In addition to that, we have discussed the bioanalytical methods for Buspirone analysis. In conclusion, this review article will help to research scholars for further method development for drug estimation in pharmaceutical dosage forms and biological fluids.

Heme is an essential cofactor for many human proteins as well as the primary transporter of oxygen in blood. Recent studies have also established heme as a signaling molecule, imparting its effects through binding with protein partners rather than through reactivity of its metal center. However, the comprehensive annotation of such heme-binding proteins in the human proteome remains incomplete. Here, we describe a strategy which utilizes a heme-based photoaffinity probe integrated with quantitative proteomics to map heme-protein interactions across the proteome. In these studies, we identified 350+ unique heme-protein interactions, the vast majority of which were heretofore unknown and consist of targets from diverse functional classes, including transporters, receptors, enzymes, transcription factors, and chaperones. Among these proteins is the immune-related interleukin receptor-associated kinase 1 (IRAK1), where we provide preliminary evidence that heme agonizes its catalytic activity. Our findings should improve the current understanding of heme's regulation as well as its signaling functions and facilitate new insights of its roles in human disease.

Forest ecosystems are the regions where there is least human interference and therefore we see luxury of plant growth. Sithkhandi forest is one of the least human interfered forests present near Bhokar region of Nanded district in Maharashtra. Arbuscular mycorrhizal fungi (AM fungi) develops symbiotic relation with most of the land plants. This association is very common in the terrestrial ecosystem throughout the world. The objective of the current study is to identify and determine frequency of various AM fungal species. Five GPS marked sampling sites were selected for isolation of mycorrhizal spores. A total 34 species belonging to genera Glomus, Acaulospora, Scutellospora, Gigaspora, Diversispora, Enterophora and Pascispora were reported. Little variation is seen in their frequency. In this study, more species diversity among Glomus followed by Acaulospora were found. High frequency percentage of Glomus mosseae has been reported at all study sites.

Nanded is one of the most biodiversity rich region of Maharastra. This area is having deciduousregions known asKinwat, Mahurand Shita-khandi forest. The regional peoples uses many traditional medicines for the treatments ofvarious diseases. The aim of current research is to survey and documentsethno-medicinal usages of family Myrtaceae.For this data collectionmany time field visits were given.All the collected data and information were confirmed using availableliterature. Total six plants of Myrtaceae were reported in the study.Syzygiun cumini(Jamun),Psidium guajava L. (Guava),Eucalyptus globules(Nilgiri) are the common plantsreported in survey includingCallistemon citrinus( Bottle brush),Syzygium aromaticum L. (Laong), andSyzygiumjambos L. The plants reported in the present study were found to be used by local peoples for the treatments of different aliments. &nbsp

In this study, we are reporting biogenic synthesis of silver nanoparticles and hydrothermal synthesis of zinc oxide nanoparticles. Using convenient mechanical milling methods, nanocomposites with superior photocatalytic and catalytic properties are synthesized. Herein, we have adopted a green, eco-friendly, and economical route for the synthesis of Ag nanoparticles using Zingiber officinalae rhizome extract in an aqueous solution. The synthesized materials were characterized using UV-Vis spectroscopy, XRD, SEMFE-SEM, FT-IR, Raman, and a particle size analyzer with zeta potential analysis. The photocatalytic activities of Ag, ZnO and their composites were studied by observing the degradation of methylene blue and crystal violet dyes under natural sunlight. Then the catalytic efficacies of synthesized nanoparticles for various organic transformation reactions were studied. Ag-ZnO nanocomposites were predicted to have improved photocatalytic activity and organic transformation reactions, allowing them to be used in environmental remediation applications.

The present day human rights advocacy can be justified on grounds of ‘positive view of freedom’. This entails ‘the view that individual freedom in the full sense involves having an opportunity for self- realization... The political content of the positive view is that, if certain resources, powers or abilities are needed for self-realization to be effectively achievable, then having these resources must be considered part of freedom itself. It is on this basis that modem revisionary liberals have defended the welfare state as a freedom- enhancing institution: it is alleged to confer needed resources on individuals and thereby to expand their chances of freedom’.( Gray.l986:pp.57,58). The view of Bentham on natural rights and the statement of Maurice Cranston on human rights sets in motion the contemporary debate on human rights. On natural rights Bentham opined that “Right is the child of law; from real laws come real rights, but from imaginary law, from “laws of nature”, come imaginary rights...Natural rights is simple nonsense,, natural and imprescriptibly rights...rhetorical nonsense, nonsense upon stilts’.(Quoted in Cranston, Maurice 1967:p.44). According to Maurice Cranston, “The traditional human rights are political and civil rights such as the right to life, liberty and a fair trial. What are now being put forward as universal human rights human rights are social and economic rights such as the right to unemployment insurance, old-age pensions, medical services and holidays with pay. I have both a philosophical and political objection to this. The philosophical objection is that the new theory of human rights does not make sense. The Political objection is that the circulation of a confused notion of human rights hinders the effective protection of what are correctly seen as human rights.(Ibid.p.43). The views expressed by Cranston appealed to me as relevant on perusal of the Vienna declaration and Programme of action adopted by the World Conference on Human rights in Vienna on 25 June 1993.

More than 70% of farms in Scarcity Zone of Maharashtra are small and marginal and are thus vulnerable to climate variability. Some factors, such as increased temperatures and longer droughts periods, are likely to depress production. Managing climate risks is a major challenge of today and for the future. To extend the period of forecast for 3-7 days i.e., medium range weather forecast for the benefit of farming, community the India Meteorological Department has been issuing district level medium range forecast to the 127 agrometeorological field units in the country. Under this project apart from weather forecasts, agro-advisories based on weather are also being issued for the benefit of farming community by the AMFU’s. Advisories are farmers bulletin, which take into account the prevailing weather, soil and crop condition, weather forecasts and, suggest measures to minimize the losses (crop or livestock) and effective utilization of inputs (irrigation, fertilizers pesticides etc.,) and also suggest contingent crop planning.The following points are to be kept in mind for preparing effective agro-advisory bulletins:Identification of weather sensitive field operations, Accurate weather forecast taking into cognizance local weather. Real time information on crops (major crops, varieties, sowing time, phonological stage, status of pests and diseases etc.). Reliable source of information .Crop weather calendars, easily understandable language.The feedback is collected from the contact progressive farmers, on usefulness of the advisories as well as suggestions for its improvements. Systemtic study conducted by this unit on economic impact of the project in six villages in Solapur District revealed that there is a benefit of 12- 23% due to adoption of agromet advisories. The contingency plans are needed if following conditions prevail :Failure of south-West Monsoon, Delayed onset or early withdrawal of monsoon, Deficit or erratic rainfall, Damage to crops due to cyclones floods etc. Crop loss due to droughts, Insufficient supply of irrigation water or late release of canal water, Long dry spells, Heat or cold waves, Severe pest or disease outbreaks due to favorable weather conditions.Medium range weather forecast is useful in issuing location specific weather based Agro-advisors to tailor the agricultural operations. By closely monitoring seasonal conditions and using medium range weather forecast an effective contingency cropping strategy is possible. Timely dissemination of these advisories/ contingency crop plans/measures will help the farmers to maximize the yield by optimum use of inputs and enhance the economic returns of the farmers.

Coumarin 2H-1-benzopyran-2-one core has been a field of attention due to its exclusive propensity to accept variable classes of replacements which proves it as the origin for multi-disciplinary activities. Many researchers replicates that coumarin derivatives synthesized by structural modifications & alterations that exhibits diverse pharmacological activities like Anticancer, Carbonic Anhydrase Inhibition, Anti-bacterial, Antifungal, Antiviral, Anticoagulant, Anti Alzheimer activity, Anticonvulsant Activity, Anti-inflammatory etc.The motive of this study is to review, various substituted coumarin derivatives and provide the opportunity of designing & synthesizing novel coumarin based drugs and exploring their possible derivatives in the cure of numerous disorders. This review summerizes the recent development in synthesis of Coumarin based derivatives with various biological activities.

Objectives A retrospective study was undertaken to investigate the circulating dengue virus (DENV) serotypes and genotypes in India in 2018. Methods In total, 4963 samples referred to virus research diagnostic laboratories (n=21), the Indian Council of Medical Research-National Institute of Virology (ICMR-NIV) and ICMR-NIV field units (n=2) for diagnosis of dengue in 2018 were tested using a real-time reverse transcription polymerase chain reaction assay for the presence of DENV serotypes. Representative samples were sequenced for the envelope (E) gene. Results Regional diversity was observed with regard to the dominant circulating serotypes. DENV-2 was found to be the most common serotype in many states. Thrombocytopenia, petechiae and malaise were associated with DENV-2 infection. Phylogenetic analyses of DENV E gene sequences revealed the circulation of genotypes I and V of DENV-1, two lineages of DENV-2 genotype IV, DENV-3 genotype III and DENV-4 genotype I. Conclusions This study found regional differences in the prevalence of circulating DENV serotypes in India, and provides baseline data for continuous molecular surveillance. Molecular surveillance may have implications for predicting large-scale outbreaks of dengue if regional shifts in the predominantly circulating serotypes and genotypes are detected during the early phase of the dengue season.

ObjectiveTo evaluate pertussis antibody status of pregnant women and their newborns, and the impact of antenatal immunisation.DesignObservational study.SettingHospitals in urban western India.ParticipantsPregnant women and their newborns.MethodsPertussis antibody titres in mothers and their newborns were determined. Vaccinated and unvaccinated mothers and their newborns were compared for baseline characteristics, geometric mean titres (GMTs) and placental transfer ratio of antibodies. Multivariate logistic regression was performed to understand the influence of different factors on protective antibody titres.ResultsOf 284 mother–infant pairs, 75 mothers and 73 of their newborns were seropositive for anti-pertussis toxin (PT) IgG antibodies. 94 women were vaccinated in pregnancy; 51 (54.3%) of these mothers and newborns were PT IgG positive, compared with 24 (12.3%) of the women (and 22 newborns) not vaccinated in pregnancy. Women vaccinated in pregnancy and their newborns had higher GMT (30.88 and 32.54 IU/mL), compared with women who were not vaccinated (12.63%, 2.24 IU/mL) and their newborns (11.58%, 2.53 IU/mL). Placental transfer ratios in newborns of mothers vaccinated in pregnancy and those who had childhood immunisation or natural immunity were similar (1.05 and 1.12, respectively). Protective titres of antibodies at birth (>20 IU/mL) were observed in 72.3% vs 21% of newborns of vaccinated and unvaccinated pregnant women, respectively; influenced by mother’s vaccination status and seropositivity.ConclusionProtection against pertussis is low in newborns of mothers who are only immunised during childhood. Vaccination early in pregnancy boosts maternal and neonatal immunity.

Cadmium (Cd2+)-substituted cobalt ferrite thin films with configuration Co1−xCdxFe2O4 (x = 0.0 to 1.0 in steps of 0.2) were grown via spray pyrolysis. The influence of Cd2+ substitution on structural and functional properties was investigated. X-ray diffraction analysis clearly shows a single-phase cubic spinel geometry (Fd3m space group). The ultrafine nanocrystallites with average crystallite dimensions of 11–15 nm were obtained. The surface topography was inspected by scanning electron microscopy. The uniform distribution of the crystallites in nanosize dimensions (10–14 nm) was also supported by transmission electron microscopy. The contact angle measurements of the fabricated thin films demonstrate special affinity towards water molecules. FTIR spectra affirmed the construction of spinel ferrite structure and the band position was influenced by Cd2+-substitution. The optical band gap energy (Eg) can be tuned by Cd2+ -substitution and decreases from 2.98 to 2.10 eV viewing the semiconducting performance. The PL investigation showed the distinguishing near-band-edge emission at about 700 nm, which can be ascribed to the re-grouping of electrons with light-produced holes in oxygen vacancies and creation of intrinsic defects. Magnetic properties, i.e. saturation magnetization (Ms, 412.84–111.47 emu/cc), remanence magnetization (Mr, 44.83–2.18 emu/cc) and coercivity (Hc, 402.12–78.12 Oe), decreased with increasing diamagnetic Cd2+ substitution due to a decrease in net magnetization.

SLC15A4 is an endolysosome-resident transporter that is intimately linked with autoinflammation and autoimmunity. Specifically, SLC15A4 is critical for Toll-like receptor (TLR) 7, 8, and 9 as well as the nucleotide-binding oligomerization domain-containing protein (NOD) 2 signaling in several immune cell subsets. Notably, SLC15A4 is essential for the development of systemic lupus erythematosus in murine models and is associated with autoimmune conditions in humans. Despite its therapeutic potential, to our knowledge no pharmacological tools have been developed that target SLC15A4. Here, we use an integrated chemical proteomics approach to develop a suite of chemical tools, including first-in-class functional inhibitors, for SLC15A4. We demonstrate SLC15A4 inhibitors suppress endosomal TLR and NOD functions in a variety of human and mouse immune cells and provide early evidence of their ability to suppress inflammation in vivo and in clinical settings. Our findings establish SLC15A4 as a druggable target for the treatment of autoimmune/autoinflammatory conditions.One-Sentence SummaryDiscovery and characterization of SLC15A4 inhibitors with anti-inflammatory activity.

Heart failure with preserved ejection fraction (HFpEF) accounts for 15–20% of patients with heart failure (HF) in India. Diagnosis is by clinical features supported by biomarkers and echocardiography. Lifestyle modifications, control of risk factors to optimum levels, and treatment of comorbidities are essential in the management of HFpEF. Spironolactone and sacubitril-valsartan [angiotensin receptor neprilysin inhibitor (ARNI)] are beneficial in subsets of HFpEF, especially with lower range of ejection fraction (EF). Sodium-glucose co-transporter-2 inhibitors (SGLT2i)—empagliflozin and dapagliflozin and probably sotagliflozin are the only currently available drugs which have shown benefits in HFpEF, mostly by reducing hospitalizations. The benefit of SGLT2i is evident in both diabetic and nondiabetic subsets.

Garlic (Allium sativum L.) is an important constituent of many of traditional medicines. The nutrient composition and biochemical ingredients of garlic vary among varieties and locations. The current experiment was conducted with 35 genotypes of garlic to study variation in morphological and biochemical properties among these genotypes. The weight of bulbs ranged from 6.9 g to 22.6 g. Highest number of clove bulb-1 was recorded in collection -286 (44.6) followed by GG-2 (40.6). Clove weight was higher in collection - 316 (1.41 g). The dry weight ranged from 28.6 per cent to 38.65 per cent. Highest total soluble solids were found in collection -79 (35.1°Brix). Potassium, iron and zinc content were higher in GG-2 (1.70%, 47 ppm and 19.2 ppm, respectively). Sulphur and copper content were higher in G-41. Manganese content ranged from 6.90 to 23.1 ppm. Highest anthocyanin pigment was found in the peel of cv. Godavari (5.35 mg). There was not much difference in anthocyanin content in pulp of purple and white colour varieties. Pyruvic acid content ranged from 20.9 µ mol ml-1 to 24.9 µ mol ml-1. Over all cvs. G-50, G-41, collection -316 were found superior over others.

Waterborne polyurethane dispersions used in surface coatings have recently gained a lot of interest as the need for more and more alternatives in the case of chemical components has arisen. Nevertheless, WPUDs can be used to obtain coatings with superior qualities. Hence, a study of various research papers, articles, and other literature is being presented in the following review article. We have studied various aspects of improvement and advancement in the field of WPUDs. We have focused mainly on thermal and mechanical property elevation brought about by physical and chemical modifications. We have also described raw materials and the basic chemistry of WPUDs taking into consideration how properties can be achieved by alterations in these two aspects as well.

In this study, a novel synthetic method for cobalt oxide (Co3O4) nanoparticles using Bos taurus (A-2) urine as a reducing agent was developed. In addition to this ZnO nanorods were produced hydrothermally and a nanocomposite is formed through a solid-state reaction. The synthesized materials were characterized through modern characterization techniques such as XRD, FE-SEM with EDS, DLS, zeta potential, FT-IR, Raman spectroscopic analysis, and TGA with DSC. The free radical destructive activity was determined using two different methods viz. ABTS and DPPH. The potential for BSA denaturation in vitro, which is measured in comparison to heat-induced denaturation of egg albumin and results in anti-inflammatory effects of nanomaterial was studied. All synthesized nanomaterials have excellent antibacterial properties, particularly against Salmonella typhi and Staphylococcus aureus. The composite exhibits excellent antioxidant and anti-inflammatory activities in comparison to pure nanomaterials. This reveals that these nanomaterials are advantageous in medicine and drug administration.

A host association for Syncola crypsimorpha (Meyrick, 1922) is discovered after 100 years, since its original description. In India, two blastobasid species, Syncola crypsimorpha (Meyrick, 1922) and S. pulverea (Meyrick, 1907) (Lepidoptera: Gelechioidea), are predators of cultured lac, Kerria lacca (Kerr, 1782) (Hemiptera: Kerridae). Descriptions, diagnoses, and images and illustrations of the adult stage, including the male and female genitalia, for these two species are provided to facilitate identifications. A lectotype for Syncola crypsimorpha is designated herein.

The nanoparticles of ZnxNi1-xFe2O4 (0.0 ≤ x ≤ 1 in steps 0.5) were prepared with the application of urea (CH4N2O) as a fuel in the sol-gel auto combustion technique and also used to remove the Rhodamine B (RhB) from the industrial waste-water. Before the process of water treatment began, the Ni–Zn ferrite nanoparticles were characterized by XRD, FT-IR, FE-SEM, VSM, and UV–Vis spectrophotometer. The measurement of XRD confirms that the cubic structure with the Fd-3m space group and the crystalline size was also calculated with the help of the Williamson-Hall (W–H) plot. The FT-IR spectra of Ni–Zn ferrite nanoparticles show two prominent absorption bands in the range of 390–560 cm−1. Optical properties of the prepared nanoparticles were evaluated using UV–Vis spectrophotometer and PL studies. The photocatalytic activity of the prepared NPs was studied under the sunlight and the percentage of maximum degradation was found to be 90%, 94%, and 98%, respectively, under 180 min.

Monodispersed Mn0.5Zn0.5Fe2O4 (~ 14 nm) nanoparticles were prepared by using a chemical co-precipitation technique. The direct mixing method has been used to prepare ferrofluid (base fluid-water) and to investigate their properties for the application of magnetic hyperthermia. Phase identification, crystal structure, and average crystallite size of the prepared samples were revealed in the XRD analysis. It confirms the Fd3m space group cubic spinel structure and average crystallite size ~ 14 nm. From TEM evaluation, the average particle size was found at ~ 16 nm. The 41.12 emu/g magnetization value of the Manganese Zinc Ferrite (MZF) nanoparticles (NPs) was found at room temperature. A negligible coercivity and remanence values confirm the superparamagnetic behavior of MZF nanoparticles at room temperature were confirmed by vibrating sample magnetometer (VSM) analysis. The induction heating analysis on water dispersed MZF Magnetic NPs at 4 kA/m AC magnetic field amplitude and 280 kHz frequency was conducted to use them in the application of hyperthermia. The result specifies that the heating potential of prepared ferrofluids can be reached within 65 s of hyperthermia temperature (42 °C) at lower 4 mg/mL content, indicating that the prepared material can be used as a heating agent for the treatment of magnetic hyperthermia. The specific absorption rate (SAR) was found to be 110.90 W/g. Thus, the obtained results suggest that the prepared MZF nanoparticles are a promising candidate for hyperthermia therapy due to their high heat-generating ability with less time at a lower concentration.

The time lag between the identification and the initiation of the actuation protocol is more in conventional fire combat system. This in turn increases the response time resulting in financial loss as well as injuries to human beings. In this paper an efficient method of fire combat is proposed to eliminate resource loss. This system extinguishes fire before it reaches its destructive level. It eliminates all the flaws of the conventional fire extinguishers and improves the damage limitation by raising an alarm. Further by applying HAAR cascade classifier machine learning algorithm, accuracy of 70-75 % is achieved to detect fire. It also provides minimum latency and optimal response in detecting fires and differentiating them from false triggers. It is observed that the response time of proposed fire combat system is 2-4 seconds. The automatic mode is reliable in the presence of multiple units that are deployed in the same area of interest. The system is able to cover the entire hemispheric 3D volume of the room as per the industrial and domestic safety standards.

Crystalline (ZnF NPs) ZnFe2O4 nanoparticles were successfully prepared via the sol–gel auto-combustion approach using a citric acid polymer as a fuel for ignition. The prepared ZnF samples were analyzed by XRD, FT-IR, and EDAX affirming the formation of a single-phase, cubic, normal type spinel structure with the $${\text{Fd}}_{3\text{m}}-{\text{O}}_{\text{h}}^{7}$$ space group. An exposure of ZnF nanoparticles to the 50 kGy and 100 kGy gamma-ray leads to the significant expansion of cubic structure which increases the lattice parameter (a) to some extend. FEG-SEM images revealed the compact arrangement of homogeneous nanoparticles, roughly spherical shape of grains, and fairly vivid pores after γ-irradiation. Functional group analysis of un-irradiated and γ-irradiated ZnF NPs was carried out at room temperature (RT) by FT-IR which confirmed the companionship of the associated metal oxide bands. The temperature dependence DC- electrical resistivity of ZnF NPs was measured by a two-point probe technique and drift mobility was determined. The activation energy of conduction (∆E) was determined in the range of 0.129 eV to 0.281 eV. Moreover, an optimized dose of gamma irradiation may affect the physical properties of ZnF NPs and make them a potential candidate for various technological applications.