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1. Quantifying Argonaute 2 (Ago2) expression to stratify breast cancer

Author

M.C. Casey, A. Prakash, E. Holian, A. McGuire, O. Kalinina, A. Shalaby, C. Curran, M. Webber, G. Callagy, E. Bourke, M. J. Kerin, and J. A. Brown

Subjects
Ago2, EIF2C2, Staining, Tumour, IHC, Pattern, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Argonaute-2 (Ago2) is an essential component of microRNA biogenesis implicated in tumourigenesis. However Ago2 expression and localisation in breast cancer remains undetermined. The aim was to define Ago2 expression (mRNA and protein) and localisation in breast cancer, and investigate associations with clinicopathological details. Methods Ago2 protein was stained in breast cancer cell lines and tissue microarrays (TMAs), with intensity and localization assessed. Staining intensity was correlated with clinicopathological details. Using independent databases, Ago2 mRNA expression and gene alterations in breast cancer were investigated. Results In the breast cancer TMAs, 4 distinct staining intensities were observed (Negative, Weak, Moderate, Strong), with 64.2% of samples stained weak or negatively for Ago2 protein. An association was found between strong Ago2 staining and, the Her2 positive or basal subtypes, and between Ago2 intensity and receptor status (Estrogen or Progesterone). In tumours Ago2 mRNA expression correlated with reduced relapse free survival. Conversely, Ago2 mRNA was expressed significantly lower in SK-BR-3 (HER2 positive) and BT-20 (Basal/Triple negative) cell lines. Interestingly, high levels of Ago2 gene amplification (10–27%) were observed in breast cancer across multiple patient datasets. Importantly, knowledge of Ago2 expression improves predictions of breast cancer subtype by 20%, ER status by 15.7% and PR status by 17.5%. Conclusions Quantification of Ago2 improves the stratification of breast cancer and suggests a differential role for Ago2 in breast cancer subtypes, based on levels and cellular localisation. Further investigation of the mechanisms affecting Ago2 dysregulation will reveal insights into the molecular differences underpinning breast cancer subtypes.

Published
2019
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2. Breast cancer subtype discordance: impact on post-recurrence survival and potential treatment options

Author

Peter F. McAnena, Andrew McGuire, A. Ramli, C. Curran, C. Malone, R. McLaughlin, K. Barry, James A.L. Brown, and M. J. Kerin

Subjects
Breast cancer, Subtype, Discordance, Post-recurrence survival, Triple negative, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Recent studies have shown that breast cancer subtype can change from the primary tumour to the recurrence. Discordance between primary and recurrent breast cancer has implications for further treatment and ultimately prognosis. The aim of the study was to determine the rate of change between primary and recurrence of breast cancer and to assess the impact of these changes on survival and potential treatment options. Methods Patient demographics were collected on those who underwent surgery for breast cancer between 2001 and 2014 and had a recurrence with biopsy results and pathology scoring of both the primary and recurrence. Results One hundred thirty two consecutive patients were included. There were 31 (23.5%) changes in subtype. Discordance occurred most frequently in luminal A breast cancer (n = 20), followed by triple negative (n = 4), luminal B (n = 3) and HER2 (n = 3). Patients who changed from luminal A to triple negative (n = 18) had a significantly worse post-recurrence survival (p

Published
2018
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3. Correction to: Breast cancer subtype discordance: impact on post-recurrence survival and potential treatment options

Author

Peter F. McAnena, Andrew McGuire, A. Ramli, C. Curran, C. Malone, R. McLaughlin, K. Barry, James A. L. Brown, and M. J. Kerin

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract It has been highlighted that the original manuscript [1] contains a typesetting error regarding the authorship.

Published
2018
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4. The accuracy of breast MRI radiomic methodologies in predicting pathological complete response to neoadjuvant chemotherapy: A systematic review and network meta-analysis

Author

J P M, O'Donnell, S A, Gasior, M G, Davey, E, O'Malley, A J, Lowery, J, McGarry, A M, O'Connell, M J, Kerin, and P, McCarthy

Subjects
Network Meta-Analysis, Antineoplastic Combined Chemotherapy Protocols, Humans, Female, Breast Neoplasms, Radiology, Nuclear Medicine and imaging, Breast, General Medicine, Magnetic Resonance Imaging, Neoadjuvant Therapy, Retrospective Studies
Abstract

Achieving pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) improves survival outcomes for breast cancer patients. Currently, conventional histopathological biomarkers predicting such responses are inconsistent. Studies investigating radiomic texture analysis from breast magnetic resonance imaging (MRI) to predict pCR have varied radiomic protocols introducing heterogeneity between results. Thus, the efficacy of radiomic profiles compared to conventional strategies to predict pCR are inconclusive.Comparing the predictive accuracy of different breast MRI radiomic protocols to identify the optimal strategy in predicting pCR to NAC.A systematic review and network meta-analysis was performed according to PRISMA guidelines. Four databases were searched up to October 4th, 2021. Nine predictive strategies were compared, including conventional biomarker parameters, MRI radiomic analysis conducted before, during, or after NAC, combination strategies and nomographic methodology.14 studies included radiomic data from 2,722 breast cancers, of which 994 were used in validation cohorts. All MRI derived radiomic features improved predictive accuracy when compared to biomarkers, except for pre-NAC MRI radiomics (odds ratio [OR]: 0.00; 95 % CI: -0.07-0.08). During-NAC and post-NAC MRI improved predictive accuracy compared to Pre-NAC MRI (OR: 0.14, 95 % CI: 0.02-0.26) and (OR: 0.26, 95 % CI: 0.07-0.45) respectively. Combining multiple MRIs did not improve predictive performance compared to Mid- or Post-NAC MRIs individually.Radiomic analysis of breast MRIs improve identification of patients likely to achieve a pCR to NAC. Post-NAC MRI are the most accurate imaging method to extrapolate radiomic data to predict pCR.

Published
2022

5. British Society of Breast Radiology Annual Scientific Meeting 2016

Author

Ameerah Mohd Azmil, Gaurav Jyoti Bansal, Eleri Davies, Matthew Wallis, Fleur Kilburn-Toppin, Sian Taylor-Phillip, Anne Buckley, Nuala Healy, Aine Quinn, Sylvia O’Keeffe, Teri Ang, Anthony Maxwell, Yit Y. Lim, Elaine Harkness, Richard Emsley, Susan Astley, Soujanya Gadde, Jennifer Ferguson, Guy Stevens, Robert Hills, Kate Gower Thomas, Sabrina Rajan, Nisha Sharma, Ajit Kishore, John O’ Dowd, Claire Murphy, Ken Lindsay, Guneesh Dadayal, Anne Nielsen Moody, Madeleine Whitaker, Stephen Wolstenhulme, Jane Bull, Anne-Marie Culpan, Natalia Roszkowski, Alexis Grima, Michaela Stahnke, Caroline Rubin, Ruth Walker, Rachel Oeppen, Srikanth Puttagunta, Karen Gray, Shama Puri, Rebecca Millican-Slater, Sana Pascaline, Mohamad Hajaj, Janet Flinn, Kim Thomson, Beatrix Elsberger, Anne Turnbull, Mark Bagnall, Joanne York, Stuart Benney, Amit Goyal, Ashley Topps, Simon Barr, Panagiotis Pikoulas, Susan Pritchard, Sophie Greenhalgh, Muthyala Sreenivas, Anju Nandhra, Sheetal Sharma, Archita Gulati, Furhan Razzaq, Sana Khan, Jacqueline McKillen, Rupert Larkin, Sachin Kamat, Carla Goncalves, Alan Tan, Asha Eleti, Nithya Vidyaprakash, Michelle A. McMahon, Barbara J. G. Dall, Faisal Majid, Ramachadra Rattehalli, Vandana Gaur, Alistair Mackenzie, Lucy Warren, Mishal Patel, Mark Halling-Brown, Louise Wilkinson, Kenneth Young, James Tanner, Rachael Currie, Sharron Balyes, Julie Wragg, Georgiana Zamfir, Pallavi Ayra, Max Marsden, James Butterworth, Shona Sinha, Anil Desai, Anna Metafa, Anne Nielsen-Moody, Laura Ward, Samantha Heller, Sue Hudson, Kathryn Taylor, Argyro Xyda, Steven Allen, Elizabeth Orlowski, Kate Downey, Richard Sidebottom, Ahmad Lodhi, Anthony Howell, Gareth Evans, Yit Lim, Yan Chen, Elizabeth Lepine-Williams, Steven Henderson, Janet Litherland, Naveed Altaf, Yvonne Bury, Nerys Forester, Mei Chan Chin, Caroline Taylor, Pippa Skippage, Aneet Sian, Rita McAvinchey, Tom Evans, Sian Nisbet, Alex Murray, Raquel Clark Castillo, Hannah Markham, Timothy Thomas, Anil Jain, Jaanilka Molderson, Joseph Wan, Helen Newman, Simon Lowes, Linsley Lunt, Sadia Sultana, Varun Chillal, Rebecca Dalton, David Reeves, Jamie Sergeant, Liz Edwards, Kate Jenkins, Shaheeda Shaikh, Elizabeth O’Flynn, Laura Bombroffe, Julie Hughes, Erica Scurr, Robin Wilson, Lyn Jones, Sasirekha Govindarajulu, Ajay K. Sahu, Matthew Brown, Steve Allen, Liz O’Flynn, Nandita deSouza, Rumana Rahim, Rema Wasan, Jane Goligher, Shalini Wijesuriya, Juliet Morel, Clare Peacock, Michael Michell, Asif Iqbal, David Evans, Bhavna Batohi, Tavleen Wasan, Vivien Phillips, Eden Manuel, Gillian Bowman, Keshthra Satchithananda, Cheng Fang, Chirag Shah, Leanne Hodkin, Keiran Horgan, David Dodwell, BM Moloney, M. C. Casey, A. Breathnach, R. M. Dwyer, R. McLoughlin, K. J. Sweeney, C. Malone, M. J. Healy, M. J. Kerin, Elizabeth Mitchell, Maureen Twiddy, Hilary Dobson, Sarah Vinnicombe, Andrew Evans, David Grant, Briony Bishop, Roxanne Giggens, Shaheel Bhuva, Jennifer Royds, Francesca Camilleri, Gauripriya Babu, Carolyn Beveridge, Rebecca Geach, Katherine Klimczak, Helen Massey, Iain Lyburn, Seema Salehi-Bird, Sahithi Nishtala, Liz Gunning, Deepthi Vinayan Changaradil, Jyoti Bansal, Joanna Davis, Ashwini Sharma, Elena Del Voscovo, Harriet Etheridge, Aisling Butler, David S. J. Fenne, Gary Rubin, Helen Burt, Nick Ridley, Sarah Taylor, Subodh Seth, and Archana Seth

Subjects
0301 basic medicine, medicine.medical_specialty, Digital mammography, Interval cancer, business.industry, Screening mammography, medicine.disease, 3. Good health, Screening programme, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Breast cancer, 030220 oncology & carcinogenesis, Family medicine, Chi-square test, Retrospective analysis, Medicine, business, Pre and post
Abstract

Jennifer Ferguson2, Guy Stevens1, Robert Hills2, Kate Gower Thomas1 1Breast Test Wales, Cardiff, UK; 2Cardiff University School of Medicine, Cardiff, UK Correspondence: Jennifer Ferguson Introduction To determine the rate and classification of interval breast cancer (IC) in the two years preceeding and following the introduction of digital mammography in 2011 in a national screening programme. Methods Two 2-year bands were used to ensure completed data for pre and post digital groups. Retrospective analysis of a prospectively collected database of IC was undertaken, identifying women who had undergone screening in the two years prior to and after the introduction of digital screening mammography (1.1.10 until 31.12.11 and 1.1.12 until 31.12.13). Chi squared analysis was used to compare the rate between the two groups and the rate of false negative (FN) and minimal signs (MS) categories considered together. Results Of 87,868 screened before digital between 1.1.10 and 31.12.11, 103 developed IC (0.12%) and of 100,672 screened with digital between 1.1.12 and 31.12.13, 145 developed IC (0.14%) (p = 0.12). Those women with FN and MS interval cancer numbered 17 (16.5%) predigital and 41 (28.3%) with digital; (p = 0.04). The number of true IC was similar in the pre (49.5%) and post (46.9%) groups. Conclusion The rate if IC is similar to the NHSBSP standard (1.2 per 1000 women screened). Despite earlier groups indicating that digital technology will lessen the number of IC, especially those ‘missed’ (FN and MS groups) which are often asymmetric densities and poorly defined masses, this has not been found in our study. The reasons for this will be discussed and examples will be shown.

Published
2016

6. Follow-up arrangements for breast cancer patients; is it appropriate to transfer surveillance to general practitioners?

Author

D, Kerrigan, P, Waters, M, Ryan, M, Irfan, J, Hanaghan, W, Khan, M J, Kerin, and K, Barry

Subjects
Adult, Attitude of Health Personnel, Surveys and Questionnaires, General Practice, Humans, Physicians, Family, Breast Neoplasms, Female, Patient Preference, Postoperative Period, Survivors, Medical Oncology, Delivery of Health Care
Abstract

The aim of this study was to examine the evidence for hospital follow up of breast cancer survivors and to identify patient preferences for hospital or community follow-up. We surveyed General Practitioner attitudes towards community follow-up and quantified the incidence of new or recurrent cancers within a patient cohort to identify their primary symptoms and thus cancer detection in the community. A 22 item questionnaire was distributed to 101 breast cancer survivors from a cohort of 921 treated patients. A 9 item questionnaire was distributed to 81 General Practitioners. Patients are reassured by hospital outpatient appointments, n=63 (74%) but have high levels of confidence in General Practitioner follow-up, n=57 (67%). General Practitioners are equally divided regarding their support for the transfer of follow-up (51%, 49%). Ten of the 14 new cancer episodes were associated with obvious clinical signs (p0.05). The proposed transfer of follow-up for patients to general practice by the national cancer control programme is appropriate.

Published
2014

7. Irish Society of Gastroenterology

Author

P. K. Neelamakam, E. Brazil, S. Attwood, O. Traynor, J. Yaqoob, M. I. Khan, D. O’Toole, N. Noonan, C. Carey, D. Kelleher, D. G. Weir, P. W. N. Keeling, D. Monahan, L. Cogan, R. Willoughby, J. Jackson, A. Whelan, C. Feighery, G. Z. Kaminski, A. Conroy, S. Dooley, N. A. Parfrey, P. McEneaney, C. O’Morain, J. P. McGrath, R. C. Stuart, J. Hill, P. J. Byrne, C. Timon, S. C. S. Chung, A. VanHasselt, T. P. J. Hennessy, D. Hamilton, D. Mulcahy, D. Walsh, C. Farrely, W. Tormey, J. Fielding, G. Watson, A. Cherukuri, M. Maloney, D. O. Toole, M. Corcoran, J. Coffey, F. Butt, D. McAvinchey, P. V. Delaney, G. J. Burke, S. Youngprapakorn, U. Srinivasan, N. Leonard, C. O’Farrelly, C. O. Morain, C. A. Whelan, E. Barry, C. Collins, P. Costello, C. O’Herlihy, D. P. O’Donoghue, C. Clabby, J. McCarthy, E. Kenny-Walsh, M. J. Whelton, M. Morrin, F. Khan, P. Delaney, J. O’Keeffe, K. Mills, M. A. Bennett, E. W. Kay, H. Mulcahy, M. Leader, D. T. Croke, X. G. Fan, I. Khan, S. Keating, C. Morrison, M. Buckley, F. M. O’Reilly, C. Darby, M. G. Courtney, G. M. Murphy, J. F. Fielding, C. J. O’Boyle, T. J. Boyle, K. Mulhall, M. J. Kerin, D. Courtney, D. S. Quill, H. F. Given, S. Kehoe, R. Quirke, R. B. Stephens, S. Norris, G. McEntee, J. Hegarty, C. Farrelly, D. Thottaparambil, R. Thomas, G. Houghton, S. Sachithanandan, A. Geoghegan, S. Doyle, C. McCaul, T. N. Walsh, R. Farrell, B. Gusau, M. S. O’Mahoney, S. AlBloushi, J. Sachithanandan, J. Walshe, M. Carmody, J. Donohoe, A. G. Shattock, N. Parfrey, S. Lynch, L. Madrigal, J. McEntee, R. Murphy, Z. Ahmed, M. Ryan, C. Montwill, A. Morgan, P. Smith, F. Walker, A. Murphy, M. Moloney, S. McGrath, E. Taraneweh, A. K. Bhatia, D. O’Keeffe, P. McCarthy, E. Rajan, S. Albloushi, B. O’ Farrell, A. Shattock, D. Kearney, J. Lee, F. Gleeson, B. McNamara, J. Cuffe, G. C. O’Sullivan, B. J. Harvey, B. Curran, E. Kay, L. Lawler, S. E. A. Attwood, G. Bourke, J. Hyland, W. A. Owens, C. M. Loughrey, J. A. McAleer, K. G. McManus, J. F. Dillon, F. C. Wong, T. C. N. Lo, K. H. Chan, J. N. Plevris, N. D. C. Finlayson, J. D. Miller, I. A. D. Bouchier, P. C. Hayes, S. V. Walsh, L. J. Egan, C. E. Connolly, F. M. Stevens, E. L. Egan, C. F. McCarthy, Q. Y. Ma, G. D. Magee, J. E. Ardill, K. D. Buchanan, B. J. Rowlands, P. McGettigan, R. Chan, B. O’ Shea, J. McManus, J. Feely, J. Donoghue, N. Fanning, J. Mathias, P. Gillen, W. A. Tanner, F. B. V. Keane, D. M. Campbell, V. Donnelly, D. O’Connell, M. Behan, P. R. O’Connell, C. S. Ko, K. Mealy, B. M. Gusau, M. Goggins, J. Yakoub, R. J. Farrell, and N. Mahmud

Subjects
medicine.medical_specialty, Irish, business.industry, Ophthalmology, medicine, language, Library science, General Medicine, business, language.human_language
Published
1995

8. Sir Peter Freyer Memorial Lecture and Surgical Symposium 15th and 16th September, 1995

Author

J. Calleary, C. Tansey, J. McCormack, S. Kapur, J. Doyle, J. Flynn, A. J. Curran, D. Smyth, B. Kane, M. Toner, C. V. I. Timon, K. J. Cronin, J. O’Donoghue, F. X. Darmanin, J. McCann, F. Campbell, H. P. Redmond, C. Condron, D. Bouchier-Hayes, K. Aizaz, S. W. MacGowan, A. F. O’Donnell, D. A. Luke, E. McGovern, M. Morrin, F. Khan, P. V. Delaney, S. M. Lavelle, B. Kanagaratnam, V. Cuervas-Mons, A. Gauthier, C. Gips, R. Marques dos Santos, G. P. Molino, A. Theodossi, D. D. Tsiftsis, C. J. O. Boyle, T. J. Boyle, M. J. Kerin, D. M. Courtney, D. S. Quill, H. F. Given, D. F. O’Brien, E. J. Kelly, J. Kelly, D. Richardson, N. F. Fanning, R. Brennan, P. G. Horgan, F. B. V. Keane, S. Reid, C. Walsh, R. Patock, J. Hall, D. Evoy, M. Magd-Eldin, D. Curran, P. Keeling, N. Ade-Ajayi, L. Spitz, E. Kiely, D. Drake, N. Klein, D. M. O’Hanlon, D. Karat, K. Callanan, W. Crisp, S. M. Griffin, P. M. Murchan, B. Mancey-Jones, P. Sedman, C. J. Mitchell, J. Macfie, D. Scott, S. Raimes, C. J. O’Boyle, D. Maher, P. C. Willsher, J. F. R. Robertson, M. Hilaly, R. W. Blarney, S. G. Shering, S. Mitrovic, A. Rahim, E. W. McDermott, N. J. O’Higgins, C. A. Murphy, D. Morgan, C. W. Elston, I. O. Ellis, M. P. O’Sullivan, M. G. O’Riordain, J. P. Stack, M. K. Barry, J. T. Ennis, J. M. Fitzpatrick, T. F. Gorey, J. Kollis, H. Mullet, D. F. Smith, A. Zbar, M. J. Murray, E. W. M. McDermott, P. P. A. Smyth, N. Kapucouglu, S. Holmes, P. Holland, P. T. McCollum, A. da Silva, L. de Cossart, D. Hamilton, C. J. Kelly, K. Stokes, P. Broe, J. Crinnion, P. A. Grace, N. Morton, N. Ross, S. Naidu, P. Gervaz, R. J. Holdsworth, P. A. Stonebridge, A. O’Donnell, K. Carson, D. Phelan, S. McBrinn, D. McCarthy, H. Javadpour, J. McCarthy, M. Neligan, M. T. P. Caldwell, J. P. McGrath, P. J. Byrne, T. N. Walsh, P. Lawlor, C. Timon, R. C. Stuart, K. Murray, A. Carney, J. G. Johnston, B. Egan, P. R. O’Connell, J. Donoghue, A. Pollock, D. Hyde, D. Hourihan, W. A. Tanner, J. Donohue, N. Fanning, P. Horgan, A. Mahmood, K. Dave, J. Stewart, A. Cole, R. Hartley, T. G. Brennan, J. M. O’Donoghue, S. T. O’Sullivan, E. Beausang, J. Panchal, M. O’Shaughnessy, P. O’Grady, R. W. G. Watson, D. Johnstone, J. O’Donnell, E. McCarthy, N. Flynn, T. O’Dwyer, C. Curran, S. Duggan, S. Tierney, Z. Qian, P. A. Lipsett, H. A. Pitt, K. D. Lillemoe, J. Kollias, D. A. L. Morgan, I. S. Young, M. C. Regan, J. G. Geraghty, C. B. O. Suilleabhain, M. L. Rodrick, A. F. Horgan, J. A. Mannick, J. A. Lederer, T. P. J. Hennessy, M. Canney, K. Feeley, C. E. Connolly, H. Abdih, N. Finnegan, M. Da Costa, M. Shafii, A. J. Martin, D. Mulcahy, M. Dolan, M. Stephens, F. McManus, M. Walsh, D. P. O’Brien, J. P. Phillips, T. A. Carroll, D. O’Brien, D. Rawluk, T. Sullivan, K. Herbert, M. Kerins, M. O’Donnell, D. Lawlor, M. McHugh, G. Edwards, J. Rice, J. P. McCabe, J. Sparkes, S. Hayes, M. Corcoran, H. Bredin, D. O’Keeffe, J. Candon, E. D. Mulligan, T. H. Lynch, D. Mulvin, L. Vingers, J. M. Smith, H. Corby, K. Barry, I. Eardley, J. Frick, B. Goldwasser, P. Wiklund, E. Rogers, R. Weaver, P. T. Scardino, R. Kumar, P. Puri, A. B. Adeyoju, T. Lynch, J. Corr, T. E. D. McDermott, R. Grainger, J. Thornhill, M. Butler, D. Keegan, N. Hegarty, P. McCarthy, A. H. Mirza, M. O’Sullivan, P. Neary, T. P. F. O’Connor, D. McCormack, K. Cunningham, N. Cassidy, K. Mulhall, M. Murphy, A. Puri, B. Dhaif, P. D. Carey, R. J. Delicata, F. Abbasakoor, R. B. Stephens, A. J. Hussey, B. Garrihy, D. J. Nolan, O. J. McAnena, R. Fitzgerald, D. Watson, B. J. Coventry, P. Malycha, S. C. Ward, S. P. Y. Kwok, W. Y. Lau, J. W. Bergman, G. E. B. Hacking, C. Metreweli, A. K. C. Li, P. Madhavan, J. Donohoe, M. O’Donohue, D. A. McNamara, and M. K. O’Donohoe

Subjects
business.industry, Medicine, General Medicine, business, Classics
Published
1995

9. Circulating miR-34a levels are reduced in colorectal cancer

Author

M, Nugent, N, Miller, and M J, Kerin

Subjects
Adult, Aged, 80 and over, Male, Adolescent, Middle Aged, MicroRNAs, Young Adult, Case-Control Studies, Biomarkers, Tumor, Humans, Female, Prospective Studies, Colorectal Neoplasms, Aged
Abstract

MicroRNAs (miRNAs) are small, non-coding RNA segments that regulate gene expression via post-transcriptional inhibition and have roles in cell differentiation, proliferation, and apoptosis. Expression differs between tumor and normal tissue in several malignancies. Most work has focused on tissue and cell expression with few reports of circulating miRNAs in colorectal cancer. Available biomarkers for colorectal cancer have limited sensitivity and specificity, thus there is a need for new markers.This study aimed to identify miRNAs that are differentially expressed in the blood of colorectal cancer patients compared to controls and to establish if this is specific to colorectal cancer and thus could be utilized as potential tumor markers.Blood samples were collected from 63 colorectal cancer patients and 45 controls. Expression of 7 target miRNAs (miR-143, miR-145, miR-21, miR-30a-3p, miR-31, miR-34a, and miR-92) was measured using RQ-PCR. Results were correlated with clinicopathological data and analyzed. Analysis of differentially expressed circulating miRNAs was expanded to include 62 patients with prostate, renal, breast, and melanoma cancers.Analysis of the relative quantification of the target miRNAs showed significantly reduced expression (P = 0.004) of miR-34a in colorectal cancer. MiR-34a was also significantly reduced in breast cancer (P = 0.019).This study demonstrates significantly reduced expression of circulating miR-34a in colorectal and breast cancer. This may have future application as part of a biomarker profile.

Published
2012

10. 19th Sir peter freyer memorial lecture and surgical symposium 16th and 17th September 1994

Author

D. A. McEvoy, B. Connolly, V. Donohue, D. O’Halpin, H. Rowley, T. P. O’Dywer, C. Timon, J. A. McKeever, M. A. Stokes, J. G. Bannigan, M. J. Early, D. M. Baker, Van-Tam Nguyen, D. Bush, J. Jones, J. B. Bourke, K. S. Cross, G. Durkan, M. Stokes, T. Carroll, T. Gorey, K. O’Malley, D. Mulcahy, D. McCormack, J. McElwain, S. C. Natin, T. N. Walsh, T. P. J. Hennessy, K. Carson, R. Page, W. Blunnie, D. C. Moriarty, R. W. G. Watson, D. M. Bouchier-Hayes, H. Abdih, C. J. Kelly, M. Barry, P. Burke, A. Tanner, D. J. Bouchier-Hayes, T. O’Sullivan, A. F. Horgan, D. H. L. Chin, J. A. Mannick, M. L. Rodrick, N. Finnegan, S. T. O’Sullivan, S. F. Wolf, M. C. Barry, C. Condron, R. G. K. Watson, J. D. Evans, C. A. Maxwell-Armstrong, M. K. Barry, K. K. Singh, P. Ralston, C. D. Auld, M. Henderson, J. McCormick, A. D. F. Walls, I. Keogh, M. Kerin, D. O’Hanlon, S. Walsh, P. Kent, J. Callaghan, H. F. Given, P. Madhavan, B. Golden, F. Khan, E. Murphy, N. Couse, G. Burke, P. V. Delaney, R. McLoughlin, P. Kenny, D . O’Hanlon, H. Grimes, S. Reid, P. Neary, M. Nassralla, T. K. Neelamekam, P. Horgan, O. Traynor, P. G. Horgan, J. Hyland, D. M. O’Hanlon, C. O’Boyle, M. J. Duffy, E. W. M. McDermott, D. Reilly, J. J. Fennelly, N. J. O’Higgins, A. McNamara, H. Mullett, D. O’Riordan, E. McDermott, M. Sharp, N. O’Higgins, M. Murphy, M. Little, D. Maher, A. Khalid, P. McCarthy, I. F. Given, C. Bolger, J. P. Phillips, C. Gilligan, S. Zareb, C. Roake, D. S. O’Riordain, D. Farley, C. Grant, J. van Heerden, D. P. O’Brien, M. J. Flynn, F. B. V. Keane, B. Sweeney, D. O’Riordain, A. J. Curran, W. Joyce, D. Smith, H. Gallagher, M. A. Walsh, D. Bouchier-Hayes, J. Phillips, T. O’Brien, S. W. Yusuf, A. C. Perkins, M. Frier, P. W. Wenham, B. R. Hopkinson, G. S. Makin, R. Hind, W. Yusuf, S. C. Whitaker, R. E. Hind, T. A. M. Chuter, G. C. Durkan, M. J. Grenell, M. C. Regan, T. F. Gorey, C. F. Castineira, S. J. Sheehan, M. Wali, M. P. Colgan, D. J. Moore, G. D. Shanik, G. McGreal, J. Kelly, D. Hehir, M. P. Brady, D. M. Sibbering, P. A. M. Holland, A. R. M. Wilson, R. W. Blarney, M. Khurrum Baig, N. Mulligan, B. Farrell, F. O. Cunningham, M. Magd-Eldin, P. Keeling, Y. A. Gul, S. W. Yeo, U. D. Khan, F. Lennon, M. F. Shine, V. Kalidasan, O. Fulena, E. J. Guiney, R. J. Fitzgerald, M. Corbally, A. E. Wood, C. M. Reardon, G. T. McGreal, D. J. Hehir, J. A. O’Donnell, W. O. Kirwan, A. A. Mahomed, A. Keshgar, R. Surna, M. T. Corbally, S. O’Rourke, I. Beckingham, M. C. Bishop, J. Husain, N. Hegarty, J. Calleary, I. Rafi, M. Gilmore, S. M. Saleem, H. P. Singh, T. Aherne, H. P. Redmond, J. McCarthy, D. M. Mulcahy, P. Nicholson, P. Harrington, T. Sharif, H. Smyth, G. Fenelon, J. Pegum, J. Corrigan, A. Jenkinson, A. A. El-Magbri, M. A. Gussail, M. A. Smew, A. Martin, M. Bennett, M. A. Farrell, C. Curran, M. J. Kerin, M. T. P. Caldwell, P. J. Byrne, S. Duggan, A. S. Jones, J. K. Field, D. Monaghan, C. Condren, S. Crerand, M. Kavanagh, P. Dervan, B. Hurson, K. Aiyaswami, D. Evoy, M. Walsh, B. Garrihy, S. Kaf Al-Ghazal, J. O’Donoghue, J. McCann, S. Wagstaff, C. Conroy, M. Dolan, L. Smith, L. Klenerman, J. Noel, V. Waide, D. O’Sullivan, C. Biyani, C. Powell, M. Heal, R. Surana, A. Khan, T. Lynch, T. Sami, W. Baluch, D. Hickey, M. Donovan, P. McLean, D. Murphy, S. Johnston, V. Rastogi, J. Doyle, J. R. Flynn, P. Kelly, M. F. Neligan, S. W. MacGowan, O. Sharkey, A. Bhojwani, C. Barry Walsh, E. Kay, C. Milbum, M. Leader, J. McDermott, D. Moriarty, P. Caushaj, J. M. Fitzpatrick, D. Byrne, W. P. Hederman, N. K. O’Malley, K. H. Chan, P. Fleming, G. C. O’Sullivan, K. Aizaz, A. F. O’Donnell, D. A. Luke, E. M. McGovern, N. Patil, P. Gormley, and P. M. McCarthy

Subjects
medicine.medical_specialty, business.industry, medicine, Physiology, Medical physics, General Medicine, Session (computer science), business
Published
1994

11. Seventeenth Sir Peter Freyer memorial lecture and surgical symposium

Author

E. O’Broin, J. Donohoe, K. Mealy, M. Kerin, P. Gillen, W. A. Tanner, F. B. V. Keane, P. McCarthy, S. Rubesin, H. Herlinger, I. Laufer, M. T. P. Caldwell, P. Lawlor, P. J. Byrne, T. N. Walsh, T. P. J. Hennessy, A. J. Curran, P. Gormley, K. Barry, M. McGuire, P. Marks, A. Syed Asad, B. Lane, H. I. Browne, P. Keeling, M. K. Barry, C. J. Yeo, P. K. Sauter, K. D. Lillemoe, H. A. Pitt, J. L. Cameron, S. Sostre, D. A. O’Donovan, C. J. Kelly, D. M. Bouchier-Hayes, H. P. Redmond, P. Burke, W. S. Monkhouse, J. Burke, N. Williams, T. Gorey, N. H. Afdhal, A. I. Butt, M. H. Vazir, R. Sullivan, C. E. Connolly, H. C. Bredin, J. P. Sweeney, D. Greene, R. Harkin, J. Thornton, M. R. Butler, T. E. D. McDermott, R. Grainger, J. Thornhill, M. J. Kerin, J. Wilkie, J. R. T. Monson, S. Duggan, J. McCarthy, R. G. W. Watson, D. T. Croke, M. McDermott, D. Croke, P. B. V. Keane, R. W. G. Watson, R. O’Donnell, A. F. Horgan, D. S. O’Riordain, I. Saporoschetz, J. A. Mannick, M. L. Rodrick, D. M. Baker, J. A. Jones, J. S. Nguyen-Van-Tam, D. L. Morris, J. D. Hardcastle, R. J. C. Steele, J. B. Bourke, J. H. Lloyd, S. Brown, S. E. A. Attwood, J. McGrath, M. Regan, S. McCann, R. B. Stephens, A. T. Devitt, T. J. O’Sullivan, B. J. Hurson, M. C. Regan, M. Hurson, S. J. Kirk, H. L. Wasserkrug, A. Barbul, E. R. Naidu, Tracy Sullivan, M. Colreavy, S. Kaf Al-Ghazal, J. McCann, M. Rodrick, K. J. Cronin, P. Butler, M. McHugh, G. Edwards, J. G. Geoghegan, D. J. Hehir, W. O. Kirwan, M. P. Brady, J. A. O’Donnell, D. Evoy, S. T. O’Sullivan, C. M. Reardon, M. A. Stokes, F. Bergin, P. Mercer, D. Murphy, N. O’Higgins, P. M. Cannon, J. F. R. Robertson, I. O. Ellis, R. W. Blarney, D. L. Manning, R. I. Nicolson, E. Mulligan, P. Kent, J. Ennis, M. Dowling, P. Dervan, J. M. Fitzpatrick, T. F. Gorey, D. M. Sibbering, M. H. Galea, D. A. L. Morgan, A. P. Locker, C. W. Elston, R. W. Blamey, S. P. M. Cannon, S. O’Rourke, M. Galea, A. Evans, I. Ellis, S. Johnston, J. Byrne, P. Horgan, M. Kennedy, J. Callaghan, H. F. Given, E. Mooney, S. Donohue, D. M. O’Hanlon, R. Waldron, J. Johnston, M. Stokes, E. MeDermott, M. Sharp, M. Duffy, J. Murphy, G. T. McGreal, W. Kealy, M. Neligan, K. O’Malley, G. McEntee, F. Khan, M. Morrin, P. Delaney, N. Brindley, S. Dudeney, J. Drebin, J. Geraghty, P. Broe, M. Fynes, P. G. Horgan, P. R. O’Connell, B. Golden, F. Loughnane, S. Baldota, M. O’Donnell, S. Chen, P. W. Eustace, J. G. Johnston, T. Gaffney, S. El Tawil, F. Cunningham, E. Brazil, J. Reynolds, A. Ireland, O. Traynor, D. Little, M. Barry, F. Thornton, S. Sheehan, D. J. Bouchier-Hayes, P. Fitzgerald, P. Grace, Y. Gul, D. Waldron, M. Wali, M. P. Colgan, D. J. Moore, D. G. Shanik, J. MacNamara, V. P. Lynch, H. Abdih, W. Watson, J. D. Aloisi, T. J. Boyle, H. Kim Lyerly, C. Kelly, D. O’Donovan, W. Monkhouse, J. M. O’Donoghue, C. Curran, D. O’Hanlon, D. Maher, C. Homer, M. O’Brien, M. Caldwell, R. Sheehan, P. Crean, T. O’Brien, C. Grant, J. A. Van Heerden, J. A. Lynn, B. G. O’Donovan, D. S. Quill, C. P. Delaney, J. Phillips, J. A. McKeever, M. J. Earley, A. C. B. Hooper, S. K. Al-Ghazal, K. Khan, M. McKiernan, R. McQuillan, J. R. McCabe, D. O’Farrell, J. O’Byrne, B. O’Donovan, I. Rafi, M. Gilmore, F. Fitzgerald, R. Moran, D. O’Brien, C. Pidgeon, S. Young, D. Allcutt, D. Rawluk, D. P. O’Brien, J. P. Phillips, I. Beckingham, M. Hinwood, K. Rigg, M. Bishop, H. Rowley, T. P. O’Dwyer, I. J. Beckingham, J. S. O’Rourke, M. J. S. Dennis, P. R. F. Bell, M. L. Nicholson, N. Akhtar, M. O. Corcoran, T. H. Lynch, G. Connellan, D. Mulvin, B. Boyle, M. O’Donoghue, Y. El-Tayeb, J. O’Donoghue, L. Parke, D. A. Evoy, S. E. Attwood, P. W. N. Keeling, J. Doyle, J. R. Flynn, J. Hurley, A. E. Wood, C. Duncan, A. Quershi, A. Leahy, D. Hayes, H. Osborne, H. Mashali, and R. G. K. Watson

Subjects
business.industry, Medicine, General Medicine, business, Classics
Published
1994

12. Radionuclide limb blood flow measurements to resolve diagnostic problems in vascular surgery

Author

M. J. Kerin, P. J. Robinson, A. Parkin, J. Maughan, Wilkinson D, and R. C. Kester

Subjects
medicine.medical_specialty, Reference Values, medicine, Humans, Radiology, Nuclear Medicine and imaging, Radionuclide Imaging, Technetium Tc 99m Aggregated Albumin, Peripheral Vascular Diseases, Leg, medicine.diagnostic_test, business.industry, Vascular disease, General Medicine, Blood flow, Intermittent Claudication, Vascular surgery, medicine.disease, Surgery, body regions, Stenosis, medicine.anatomical_structure, Regional Blood Flow, Angiography, Radiology, Ankle, business, Myelography, Blood vessel
Abstract

This paper describes the application of radionuclide limb blood flow measurements in 60 patients presenting to the vascular surgeons with exercise-induced leg pain. All patients were considered to be diagnostic problems since either their symptoms were atypical for peripheral vascular disease, or they had normal peripheral pulses and/or a normal ankle/brachial pressure index. Thirty-one patients were ultimately shown to have peripheral vascular disease and underwent treatment. In all these cases the limb blood flow to one or both legs was below the normal range. Twenty-three patients were shown, by myelography, computed tomography or plain radiography, to have orthopaedic disease and in all cases their limb blood flow to both legs was within the normal range. In five patients, the limb blood flow was normal and the symptoms spontaneously resolved, no cause for the leg pain having been found (one patient refused angiography). Radionuclide limb blood flow is a simple and reliable diagnostic test which is superior to the assessment of peripheral pulses or their ankle to brachial pressure index in resolving diagnostic problems in vascular surgery.

Published
1994

13. NCCP breast cancer referral guidelines--are breast cancer patients prioritised?

Author

M, Neary, A J, Lowery, A, O'Conghaile, M, Pervaz, M J, Kerin, and K J, Sweeney

Subjects
Adult, Aged, 80 and over, Adolescent, Breast Neoplasms, Middle Aged, Young Adult, Humans, Female, Guideline Adherence, Practice Patterns, Physicians', Triage, Child, Ireland, Referral and Consultation, Aged
Abstract

Following centralisation of breast cancer services, the National Cancer Control Programme (NCCP) introduced referral guidelines indicating which patients require urgent, early and routine review. This study prospectively analysed referrals to a symptomatic breast unit over 3 months to measure Primary Care Physician (GP) uptake of the NCCP referral guidelines, compare triage patterns of GP and consultant breast surgeon and evaluate the efficacy of the guidelines at identifying patients with breast cancer. 1044 consecutive referrals were categorised according to NCCP guidelines. 637 (61%) were referred using the NCCP form. GP referrals correlated well with consultant breast surgeon for patients requiring urgent review (r = 0.71, p0.001; Pearson). Patients categorised as "urgent" were more likely to have a breast biopsy compared to those categorised as "routine" (p0.0001; Chi2). The overall cancer incidence was 34 (3.3%) and significantly higher in the "urgent" group at 10.5%. NCCP guidelines were 91% sensitive for triaging breast cancer patients into the correct (urgent) category. The NCCP guidelines are accurate and should be considered the gold-standard for referral to the symptomatic breast service. Consideration should be given to a GP-delivered service to patients outside the "urgent" category.

Published
2011

14. The routine use of post-operative drains in thyroid surgery: an outdated concept

Author

R S, Prichard, R, Murphy, A, Lowry, R, McLaughlin, C, Malone, and M J, Kerin

Subjects
Adult, Aged, 80 and over, Male, Hematoma, Adolescent, Middle Aged, Thyroid Diseases, Postoperative Complications, Thyroidectomy, Drainage, Humans, Female, Aged, Retrospective Studies
Abstract

The use of surgical drains in patients undergoing thyroid surgery is standard surgical teaching. Life-threatening complications, arising from post-operative haematomas, mandates their utilization. There is increasing evidence to suggest that this is an outdated practice. This paper determines whether thyroid surgery can be safely performed without the routine use of drains. A retrospective review of patients undergoing thyroid surgery, over a three year period was performed and post-operative complications documented. One hundred and four thyroidectomies were performed. 63 (60.6%) patients had a partial thyroidectomy, 27 (25.9%) had a total thyroidectomy and 14 (13.5%) had a sub-total thyroidectomy. Suction drains were not inserted in any patient. A cervical haematoma did not develop in any patient in this series and no patient required re-operation. There is no evidence to suggest the routine use of surgical drains following uncomplicated thyroid surgery reduces the rate of haematoma formation or re-operation rates and indeed is now unwarranted.

Published
2010

15. Pregnancy associated breast cancer

Author

M, Makgasa, R S, Prichard, C, Malone, and M J, Kerin

Subjects
Adult, Survival Rate, Pregnancy, Case-Control Studies, Lymphatic Metastasis, Pregnancy Outcome, Humans, Breast Neoplasms, Female, Neoplasm Recurrence, Local, Ireland, Pregnancy Complications, Neoplastic, Retrospective Studies
Abstract

Treatment of pregnancy associated breast cancer (PABC) is usually compromised as both foetal and maternal health has to be taken into consideration. We have identified on our database twelve patients with PABC and twenty-four age-matched controls diagnosed in the same time-frame. The mean age was 36 and 38 years respectively. There was no difference in time to presentation between the two groups. The mean tumour size was 48.72 mm and 26.30 mm respectively (p = 0.001). Lymphovascular invasion and lymph node involvement were more common in the PABC group. In the PABC group, 5 patients (42%) were treated with neo-adjuvant chemotherapy including one patient in first trimester. All patients underwent surgery. Adjuvant chemotherapy was given to seven (58.3%) of the PABC patients. At median follow up of 36 months, there was a single mortality and two patients (17%) had developed recurrent disease. All children are healthy with no deformity or learning disability.

Published
2010

16. Irish society of gastroenterology

Author

A. Brannigan, N. N. Williams, M. Grahn, N. S. Williams, J. M. Fitzpatrick, P. R. O’Connell, C. V. Soong, P. Blair, M. I. Halliday, J. M. Hood, B. J. Rowlands, A. A. B. Barros D’sa, R. J. Cahill, S. Beattie, H. Hamilton, C. O’Morain, S. J. Kelly, K. E. O’Malley, W. A. Stack, D. O’Donoghue, A. W. Baird, K. J. Cronin, M. J. Kerin, J. Crowe, P. MacMathuna, J. Lennon, T. F. Gorey, A. Chua, V. O’Kane, T. G. Dinan, P. W. N. Keeling, E. Mulligan, K. L. Cronin, P. Dervan, A. Ireland, D. Murphy, G. O’Sullivan, E. Ryan, P. Kelly, J. Gilvarry, S. Sant, X. J. Fan, C. N. Shahi, M. O’Connell, D. G. Weir, D. Kelleher, J. McDevitt, J. M. O’Donoghue, P. G. Horgan, W. J. Byrne, M. McGuire, H. F. Given, M. A. Daw, P. Kavanagh, P. O’Mahony, T. Joy, F. Gleeson, A. Mullan, M. Gibney, Anne Mannion, F. M. Stevens, C. F. McCarthy, A. A. Killeen, P. M. Murchan, J. V. Reynolds, N. Leonard, P. Marks, F. B. V. Keane, W. A. Tanner, M. A. O’Connell, B. Corridan, R. Collins, R. Shannon, R. Cahill, W. P. Joyce, M. Goggin, J. Hyland, O. Traynor, A. Qureshi, M. DaCosta, N. Brindley, P. Burke, P. Grace, D. Bouchier-Hayes, A. L. Leahy, G. Courtney, H. Osbome, N. O’Donovan, M. O’Donoghue, J. K. Collins, D. Morrissey, J. E. McCarthy, H. P. Redmond, A. D. K. Hill, P. A. Grace, H. Naama, O. M. Austin, D. M. Bouchier-Hayes, J. M. Daly, D. Breslin, C. P. Delaney, S. T. O’Sullivan, G. C. O’Sullivan, W. O. Kirwan, C. D. Weir, L. T. McGrath, S. Maynard, N. H. Anderson, C. Gokulan, T. A. O’Gorman, E. Breshihan, Pin Yin Lam, R. Skehill, H. Grimes, J. A. McKeever, M. A. Stokes, D. Mehigan, T. V. Keaveny, J. Meehan, A. Molloy, C. Q’Farrelly, J. Scott, M. S. Dudeney, A. Leahy, P. A. Grace., G. McEntee, N. D. Hcaton, V. Douglas, R. Mondragon, J. O’Grady, R. Williams, K. C. Tan, H. X. Xia, C. T. Keane, C. A. O’Morain, A. O’Mahony, A. Corbett, P. Harte, H. Mulcahy, S. Patchett, W. Stack, M. Gallagher, K. Connolly, J. Doyle, J. R. Flynn, M. Maher, D. Hehir, A. Horgan, R. Stuart, M. P. Brady, P. W. Johnston, B. T. Johnston, B. J. Collins, J. S. A. Collins, A. H. G. Love, S. G. Marshall, T. G. Parks, R. A. J. Spence, H. J. O’Connor, K. Cunnane, M. Duggan, P. MacMalhuna, M. Kerin, S. E. A. Attwood, L. Viani, M. Jeffers, T. N. Walsh, P. J. Byrne, I. Frazer, T. P. J. Hennessy, G. L. Hill, W. Dickey, S. A. McMillan, C. Bharucha, K. G. Porter, H. Rolfe, J. Thornton, J. Coleman, R. B. Stephens, S. Hone, K. Holmes, I. P. Kelly, T. P. Corrigan, D. McCrory, M. McCaigue, G. R. Barclay, M. Quirke, J. E. Hegarty, D. P. O’Donoghue, D. O’Hanlon, and J. Byrne

Subjects
medicine.medical_specialty, Irish, business.industry, Ophthalmology, language, Medicine, Library science, General Medicine, business, language.human_language
Published
1992

17. Sixteenth sir peter freyer memorial lecture and surgical symposium September 13th & 14th, 1991 Session I

Author

J. Coulter, R. G. Molloy, K. T. Moran, R. Waldron, W. O. Kirwan, C. O’Suilleabhain, A. Horgan, K. Mealy, P. Burke, J. Hyland, A. F. Horgan, M. Sheehan, R. M. Browne, O. Austin, A. P. Clery, J. M. Deasy, S. Sulaiman-Shoaib, J. Soeda, D. S. O’Briain, P. Puri, E. C. Coveney, V. McAllister, E. W. M. McDermott, N. J. O’Higgins, M. Maher, M. T. P. Caldwell, P. Murchan, W. Beesley, T. M. Feeley, W. A. Tanner, F. B. V. Keane, F. Abbasakoor, S. E. A. Attwood, L P. McGrath, R. B. Stephens, E. O’Broin, M. G. Davies, J. McGinley, C. Mannion, S. Gupta, M. F. Shine, F. Lennon, G. Ninan, R. J. Fitzgerald, E. J. Guiney, B. O’Donnell, A. F. O’Donnell, D. Luke, A. E. Wood, P. G. Murphy, T. N. Walsh, A. D. K. Hill, H. Li, T. P. J. Hennessy, N. Noonan, B. Breslin, P. W. N. Keeling, A. J. Curran, D. B. Gough, I. R. Davidson, P. Keeling, D. P. O’Leary, A. Smythe, N. C. Bird, A. G. Johnson, P. Nicholson, O. Traynor, K. Dawson, J. Aitken, B. A. Cooke, S. P. Parbhoo, N. N.Williams, J. M. Daly, M. Herlyn, D. Bouchier-Hayes, R. C. Stuart, M. J. Allen, W. D. Thompson, A. L. G. Peel, D. T. Hehir, K. Cronin, A. McCann, P. A. Dervan, S. J. Heffernan, W. P. Hederman, M. H. Galea, B. Dilks, A. Gilmour, L. O. Ellis, C. W. Elston, R. W. Blarney, S. O’Rourke, A. Mookens, R. Carter, D. Parkin, N. F. Couse, C. P. Delaney, P. G. Horgan, J. M. Fitzpatrick, T. F. Gorey, J. M. O’Byrne, J. P. McCabe, M. Stephens, F. McManus, J. L.Mangan, D. A. Barr, G. J. Mulvenna, P. Maginn, W. G. Kernohan, R. A. B. Mollan, S. J. O’Flanagan, J. P. Stack, P. Dervan, B. Hurson, S. Tierney, P. Fitzgerald, T. O’Sullivan, P. Grace, J. P. Wyatt, R. J. Evans, S. P. Cusack, S. McGowan, E. McGovem, S. D. Schwaitzberg, R. J. Connolly, R. P. Sullivan, G. Mortimer, J. G. Geraghty, P. J. O’Dwyer, B. S. McGlone, D. P. O’Brien, H. A. Younis, H. F. Given, C. Phelan, J. Byrne, K. Barry, D. Gough, L. Hanrahan, F. Given, J. P. Sweeney, A. M. Korebrits, J. V Reynolds, T. F Gorey, D. M. O’Hanlon, M. A. Stokes, H. P. Redmond, J. McCarthy, P. Losty, M. Murphy, P. E. M. Butler, P. G. Grace, J. R. Novell, S. K. Hobbs, O. Smith, G. Hazlehurst, B. Brozovic, K. Rolles, A. Burroughs, S. Mallett, A. Mehta, D. Buckley, D. Waldron, D. O’Brien, C. Curran, L. Grey, A. Leahy, A. Darzi, D. Leader, P. Broe, J. G. Geoghegan, C. A. Cheng, D. C. Lawson, T. N. Pappas, D. O’Sullivan, M. M. Lieber, T. V Colby, D. M. Barrett, E. Rogers, J. Greally, H. C. Bredin, M. O. Corcoran, M. Kenny, P. Horgan, D. Headon, A. Grace, P. A. Grace, S. Cross, D. Hehir, S. O’Briain, P. Hartigan, M. P. Colgan, D. Moore, G. Shanik, S. Z. Zaidi, D. J. Hehir, K. S. Cross, D. J. Moore, D. G. Shanik, P. Lacy, J. E. Coleman, C. S. McEnroe, J. A. Gelfand, T. F. O’Donnell, A. D. Callow, D. J. Buckley, D. S. O’Riordain, J. A. O’Donnell, P. Meagher, K. Boos, P. Gillen, T. Corrigan, R. Vashisht, M. Sian, E. J Sharp, M. K. O’Malley, M. J. Kerin, D. Wilkinson, A. Parkin, R. C. Kester, M. M. Maher, R. P. Waldron, D. J. Waldron, M. P. Brady, M. Allen, T. H Lyncy, B. Waymont, L. Emtage, G. R. Blackledge, M. A. Hughes, D. M. A. Wallace, L. Mynderse, H. Grimes, F. Chambers, D. Lowe, B. Prasad, D. C. O’Sullivan, M. Barry P. Gillen, M. McNicholas, H. Bredin, T. H. O’Dowd, M. Corcoran, J. M. O’Donoghue, M. McGuire, A. McNamara, T. Creagh, R. Grainger, T. B. D. McDermott, M. R. Butler, M. Gleeson, T. E. D. McDermott, J. P. Hurley, R. Hone, M. Neligan, J. Hurley, M. White, P. McDonagh, D. Phelan, E. McGovern, F. Quinn, F. Breatnach, A. O’Meara, J. P. McGrath, S. R. McCann, E. F. Gaffney, A Hennessy, M. Leader, F. S. Taleb, M. V. McKiernan, P. J. Leyden, J. J. McCann, J. Coleman, A. Quereshi, N. Ajayi, G. McEntee, H. Osborne, D. J. Bouchier-Hayes, S. Johnston, K. O’Malley, E. Smyth, D. L Bouchier-Hayes, P. R. O’Connell, T. Gorey, O. J. McAnena, M. W. Reed, J. L. Duncan, C. S. Reilly, C. McGibney, P. Lawlor, B. Lawless, E. McGuinness, and S. Leahy

Subjects
business.industry, Medicine, General Medicine, Session (computer science), business, Classics
Published
1992

18. Fifteenth Sir Peter Freyer Memorial Lecture and Surgical Symposium Proceedings of meeting held 14th & 15th September, 1990 at University College, Galway

Author

C. Bolger, G. Fry, D. Coakley, J. Philips, N. Sheahan, J. Malone, W. P. Gray, M. O’Sullivan, T. F. Buckley, T. P. O’Dwyer, P. J. Gullane, B. P. Kneafsey, K. T. Moran, S. T. O’Sullivan, M. P. Brady, E. C. Coveney, J. G. Geraghty, N. J. O’Higgins, J. O’Beirne, P. Seighe, J. P. McElwain, J. P. McCabe, B. Waldron, J. Byme, N. Hickey, J. McCabe, J. McMahon, J. Colville, B. J. Moran, R. A. Frost, M. J. Kerin, J. J. Jaeger, C. J. Mitchell, J. MacFie, T. O’Hanrahan, N. A. Scott, D. Leinhardt, M. H. Irving, D. Gough, M. White, M. Morrin, W. Joyce, D. Phelan, J. Fitzpatrick, T. Gorey, D. Wilkinson, A. Parkin, R. C. Kester, E. J. Gibney, K. McGrath, A. J. Cunningham, D. Bouchier-Hayes, M. Barry, M. Farrell, W. Monkhouse, K. J. Dawson, D. Hehir, G. Hamilton, P. A. Grace, A. Quereschi, R. Keane, P. Broe, G. Stansby, B. Fuller, A. Connolly, J. O’Donnell, D. Little, R. M. Keane, M. Regan, P. G. Horgan, C. Curran, D. O’Brien, D. Waldron, E. Mooney, J. Greally, H. F. Given, M. J. Duffy, D. Reilly, E. Coveney, J. Geraghty, J. J. Fennelly, N. O’Higgins, C. M. O’Hare, P. L. Jones, T. A. Zoma, G. P. Hemstreet, R. G. Postier, J. E. Coleman, E. L. Chaikof, E. W. Merrill, A. D. Callow, N. N. Williams, J. M. Daly, M. Herlyn, R. Gaffney, M. Walsh, D. McShane, C. Timon, D. Hamilton, J. Connolly, P. J. Byrne, R. B. Stuart, E. Kay, T. P. J. Hennessy, D. P. O’Leary, M. Booker, T. E. Scott, W. W. LaMorte, J. G. Geraty, W. A. Angerson, D. C. Carter, J. Lyons, A. Stack, J. M. Fitzpatrick, C. Kelly, C. Augustine, J. Kennedy, T. Creagh, D. Mannion, P. Seigne, G. Fitzpatrick, M. Feeley, P. Butler, P. Grace, M. Leader, B. Curren, C. Barry-Walsh, R. Waldron, M. Shearer, S. O’Rourke, M. Galea, A. Gilmour, R. Carter, D. Parkin, R. W. Blarney, D. J. Hehir, S. P. Parbhoo, N. Rothnie, J. Crowe, C. Wells, F. Sherry, P. O’Grady, J. Byrne, S. England, J. O’Callaghan, H. Grimes, Ursula Mulcahy, P. P. A. Smyth, V. McAlister, M. J. Murray, M. J. O’Higgins, R. O. Laoide, J. B. Hourihane, E. F. Mooney, C. Brougham, D. R. Headon, C. Coleman, E. C. Coveny, S. Jazawi, T. N. Walsh, P. Lawlor, H. Li, H. Sanfey, W. P. Joyce, D. B. Gough, P. V. Delaney, T. F. Gorey, S. E. A. Attwood, A. Watson, E. Rogers, R. P. Waldron, G. Glynn, K. U. El-Bouri, J. Flynn, P. Keeling, M. G. Davies, J. Lavelle, M. F. Shine, F. Lennon, R. C. Stewart, T. P. Hennessy, M. V. McKiernan, J. G. Johnston, L. Hanrahan, H. C. Bredin, M. O. Corcoran, M. Norton, R. Flynn, M. Gleeson, R. Grainger, T. E. D. McDermott, D. Lanigan, P. McLean, B. Curran, M. J. Gleeson, D. P. Griffin, H. J. Gallagher, T. A. Creagh, D. M. Mulvin, M. G. Donovan, D. M. Murphy, P. A. McLean, D. W. Mulvin, A. O’Brien, K. L. O’Flynn, R. McDonagh, D. G. Thomas, T. H. Lynch, P. Anderson, A. T. M. Vaughan, R. P. Beaney, D. M. A. Wallace, L. Solomon, D. S. O’Riordain, P. R. O’Connell, W. O. Kirwan, Hui Li, R. C. Stuart, S. Jazrawi, T. N. Koh, S. J. Sheehan, J. McKeever, J. Donohoe, M. Carmody, D. H. Osborne, D. E. Waldron, E. Rodgers, F. Patel, P. Horgan, M. Corcoran, K. Walsh, J. M. O’Donoghue, O. J. McAnena, M. McGuire, J. Smyth, G. Keye, A. Bahadursingh, C. Delaney, A. J. Richie, J. R. P. Gibbons, M. Marples, J. Banacewicz, H. Troidl, L. Cassidy, E. J. Prenderville, P. E. Burke, M. -.P Colgan, B. L. Wee, D. J. Moore, G. D. Shanik, K. S. Cross, M. El-Sanadiki, J. J. Murray, E. Mikat, R. McCann, P. -O. Hagen, T. R. Cheatle, E. Steibe, P. D. Colebridge Smith, J. H. Scurr, K. Barry, E. Bresnihan, D. F. Courtney, D. S. Quill, D. Buckley, D. S. O’Riordan, J. A. O’Donncll, J. A. O’Donnell, A. D. K. Hill, P. J. O’Dwycr, D. P. MacErlean, N. F. Couse, D. Campbell, K. McBride, D. MacErlean, J. J. Murphy, K. Kaar, H. Docrat, S. Malik, J. Egan, I. R. Davidson, J. Hurley, and H. Rowley

Subjects
Artificial urinary sphincter, medicine.medical_specialty, Fifteenth, Chronic venous insufficiency, business.industry, Intestinal failure, General surgery, medicine, General Medicine, medicine.disease, business, Laparoscopic cholecystectomy
Published
1991

19. Irish society of gastroenterology

Author

E. J. Fitzgerald, A. Chua, C. Clabby, P. W. N. Keeling, J. M. Gilvarry, F. Keeling, O. Fitzgerald, J. F. Fielding, Elizabeth Mathai, T. O’Riordan, A. Tobin, S. Beattie, M. Cafferkey, C. T. Keane, C. O’Morain, P. J. O’Dwyer, A. Hassan, J. J. Murphy, N. J. Higgins, D. Kelly, G. P. McEntee, K. F. McGeeney, J. M. Fitzpatrick, D. P. Halpin, P. M. O’Byme, G. McEntee, T. P. Hermessy, R. B. Stephens, J. P. Hurley, P. Keeling, S. O’Brien, M. Keoghan, N. Afdhal, J. E. Hegarty, P. Burke, M. Sharp, O. Traynor, R. G. Molloy, M. G. O’Riordan, P. Gillen, W. O. Kirwan, E. Mathai, T. Keane, P. T. Byrne, R. Stuart, P. Lawlor, G. O’Sullivan, T. P. J. Hennessy, J. Hourihane, R. Stephens, F. J. Mullan, G. R. Campbell, J. Rowlands, S. T. D. McKelvey, F. I. Mullan, H. K. Wilson, W. Majury, J. Mills, A. J. Cromie, M. J. Kerin, D. O’Farrell, R. P. Waldron, J. G. Johnson, K. C. Trimble, D. P. Nunes, M. G. Courtney, L. Pomeroy, A. G. Shattock, F. M. Mulcahy, D. G. Weir, S. Ah-Kion, N. Noonan, J. Murphy, J. McNulty, M. Casey, M. X. Fitzgerald, B. Waldon, P. T. Cullen, D. Hopwood, D. Sutton, N. Kennedy, F. C. Campbell, N. MacMahon, B. Hogan, J. Murray, J. S. Doyle, J. M. Deasy, J. Carr, C. Bouchier-Hayes, A. P. Cleary, T. N. Walsh, W. F. Gawley, P. M. O’Byrne, M. I. Gleeson, D. T. Calthorpe, B. E. Lane, S. J. Heffernan, H. Sanfey, J. Steer, D. Cottell, M. Steer, T. F. Gorey, N. Nolan, P. Byme, R. Stewart, E. Nolan, E. Jones, M. MacMahon, P. Brennan, E. Carmody, D. Nizar, H. Osbome, R. L. O’Dwyer, F. Stevens, F. McCarthy, A. P. Clery, D. Bouchier-Hayes, S. Crerand, T. M. Feeley, R. Waldron, T. Corrigan, W. Hederman, and F. O’Cormell

Subjects
endocrine system, medicine.medical_specialty, endocrine system diseases, business.industry, Thyroid, General Medicine, Dapsone, medicine.disease, Asymptomatic, Gastroenterology, Anti-thyroid autoantibodies, Coeliac disease, medicine.anatomical_structure, Internal medicine, Dermatitis herpetiformis, medicine, Gluten free, Thyroid function, medicine.symptom, business, medicine.drug
Abstract

Abnormalities of the thyroid gland are said to be common in patients with dermatitis herpetiformis (DH), treated with dapsone (Thyroid abnormalities in dermatitis herpetiformis. Cunningham andZone, Annals Int.Med. 1985: 102, 194-196). Thepossibility that the goitrogenic effects of dapsone may play a role in this has not been evaluated. We therefore studied thyroid abnormalities in 40 patients with DH, 25 of whom were taking dapsone and 15 of whom were on a gluten free diet alone. All patients were examined clinically for evidence of thyroid dysfunction and blood was drawn for total thyroxine, thyrotrophin levels and thyroid microsomal antibdy titres. Six (24%) of dapsone treated patients had thyroid abnormalities, compared to 1 (7%) of the 15 patients treated with diet alone. Two patients became thyrotoxic when on treatment with dapsone. One patient had myxoedema prior to diagnosis of DH and one developed myxoedema while on dapsone. Two patients with asymptomatic goitres at the time of screening were taking dapsone and one patient on dapsone had thyroid antibodies. Thus it seems likely that the increased incidence of thyroid abnormalities in DH may be related to the effects of the sulphonamide on thyroid function.

Published
1991

20. Royal academy of medicine in ireland section of biological sciences

Author

J. P. McCabe, R. P. Waldron, M. J. Kerin, D. F. Courtney, H. F. Given, O. J. McAnena, H. Grimes, P. M. Tymkewycz, P. S. Gascoine, P. J. Gaffney, P. Felle, S. Gaine, J. Cox, R. England, J. Walsh, D. Coakley, J. Feely, E. O’Brien, K. O’Malley, L. Daly, B. L. Sheppard, E. Carroll, B. Hennelly, J. Bonnar, M. M. Fahy, V. Carragher, M. T. Kane, S. McGuinness, I. Pratt, M. P. Ryan, P. A. Cahill, S. Daly, A. K. Keenan, R. P. Barrett, M. J. Rowan, Maria Smyth, G. O’Cuinn, S. C. Sharma, S. Feely, M. Kennedy, R. G. O’Regan, Gwen Hughes, J. M. Allen, N. G. McHale, K. D. Thombury, S. Croal, J. McC Anderson, J. D. Allen, J. P. Jamison, C. G. Mercer, A. E. Gracey, N. Flynn, D. P. Otoole, A. P. Clery, A. J. Cunningham, J. W. Dundee, R. G. Ghaly, Jing Yang, A. B. Etwebi, A. A. Alazreg, S. M. Lavelle, A. Etwebi, F. R. Comerford, N. Donohoe, Godeliver A. B. Kagashe, B. E. Leonard, J. P. Kelly, C. Bannon, P. Nolan, A. Bradford, H. McGlynn, B. Kavanagh, Caroline G. Bullock, Brigid A. O’Connor, Corinna J. Pippard, W. F. M. Wallace, P. C. Holland, M. Blake, E. Redmond, E. M. Redmond, M. Brennan, R. Anwyl, A. Gaynor, R. G. Luckwill, M. Caldwell, O. Lyons, D. McNamara, A. Lynott, F. Fleming, R. Walsh, L. Farrell, C. H. Homer, P. Glacken, M. O’Brien, J. Caird, A. Grogan, C. Y. Ng, A. Arora, M. Carroll, E. McKone, D. O’Gradaigh, P. M. R. O’Reilly, M. J. T. FitzGerald, S. Tierney, J. Russell, and J. C. Folan

Subjects
business.industry, Section (typography), Medicine, Library science, General Medicine, business, Biological sciences
Published
1990

21. The clinical and pathological differences in prevalent round screen-detected and symptomatic invasive breast cancer

Author

K J, Sweeney, M R, Kell, N A, Aziz, N, Prunty, P, Holloway, M, Kennedy, F, Flanagan, and M J, Kerin

Subjects
Treatment Outcome, Disease Progression, Prevalence, Health Status Indicators, Humans, Mass Screening, Breast Neoplasms, Female, Neoplasm Invasiveness, Prospective Studies, Middle Aged, Prognosis, Ireland
Abstract

The potential benefits of breast cancer screening include the detection of cancers at a more favourable stage, however, cancers detected during the prevalent round of screening may differ from true screen-detected cancers. These differences are poorly defined. This study prospectively assessed all women between 50 and 64 years of age undergoing curative surgery for breast cancer, both screen-detected and symptomatic, in one screening centre during the prevalent round of the national breast cancer-screening programme. Four hundred and thirty seven patients (364 screen-detected and 73 symptomatic patients) underwent surgery for breast cancer. Symptomatic breast cancers were of a higher grade (p0.0001; Chi2) and less likely to be oestrogen receptor positive (49% versus 88%; p0.0001; Fisher's exact test); however there was no difference in size of tumour or axillary nodal positivity. This study suggests that tumours detected by screening during the prevalent round of a screening programme are of a more prognostically favourable type than symptomatic breast cancers in the same age group.

Published
2007

22. Estrogen receptor alpha and beta profiling in human breast cancer

Author

P, Balfe, A, McCann, A, McGoldrick, K, McAllister, M, Kennedy, P, Dervan, and M J, Kerin

Subjects
Adult, Aged, 80 and over, Reverse Transcriptase Polymerase Chain Reaction, Gene Expression Profiling, Carcinoma, Ductal, Breast, Estrogen Receptor alpha, Breast Neoplasms, Middle Aged, Immunohistochemistry, Carcinoma, Lobular, Receptors, Estrogen, Risk Factors, Biomarkers, Tumor, Estrogen Receptor beta, Humans, Women's Health, Female, Prospective Studies, Aged
Abstract

The identification of a second estrogen receptor (ER-beta) has significant implications for therapeutic strategy in breast cancer management arising from the potential agonist effect of Tamoxifen at estrogen receptor sites and as such, antiestrogen therapy may be inappropriate in patients with a dominance of ER-beta.To determine the proportion of breast cancer patients who may be so at risk, we developed a novel multiplexed RT-PCR technique to establish the relative ER-alpha and ER-beta levels in 53 primary breast cancers, 11 normal breast tissues and six cell lines. We further assessed the prognostic significance of receptor status relative to the Nottingham prognostic index (NPI). The ER-alpha and ER-beta status was also determined by immunohistochemistry using previously published and 'in-house' scoring systems.Using RT-PCR analysis, 46 tumours were hormone receptor positive (ER+) with 42 displaying ER-alpha predominance. Comparison with immunohistochemistry demonstrated 44/53 (ER-alpha) and 27/50 (ER-beta) concordance rates. There was no significant difference in the NPI between ER-alpha and ER-beta predominant cohorts or between ER+ and ER- cohorts.This study identifies the existence of a subgroup of ER+ patients in whom Tamoxifen therapy may be inappropriate and has significant implications for adjuvant therapy of primary breast cancer.

Published
2004

23. The value of axillary lymphadenectomy

Author

M R, Kell, M J, Kerin, and M R, Kelly

Subjects
medicine.medical_specialty, business.industry, Sentinel Lymph Node Biopsy, Breast Neoplasms, General Medicine, Prognosis, Oncology, Axillary Lymphadenectomy, Predictive Value of Tests, Lymphatic Metastasis, Axilla, medicine, Humans, Lymph Node Excision, Surgery, Female, Radiology, business, Value (mathematics), Randomized Controlled Trials as Topic
Published
2003

24. Serum vascular endothelial growth factor in breast cancer: its relation with cancer type and estrogen receptor status

Author

K, Heer, H, Kumar, J R, Read, J N, Fox, J R, Monson, and M J, Kerin

Subjects
Vascular Endothelial Growth Factor A, Lymphokines, Vascular Endothelial Growth Factors, Carcinoma, Ductal, Breast, Mucin-1, Breast Neoplasms, Endothelial Growth Factors, Carcinoembryonic Antigen, Carcinoma, Lobular, Receptors, Estrogen, Humans, Female, Lymph Nodes, Carcinoma in Situ, Neoplasm Staging
Abstract

Angiogenesis is essential for tumor growth. Vascular endothelial growth factor (VEGF) is one of the most potent angiogenic cytokines. In breast cancer, tumor VEGF has been shown to have a good correlation with relapse-free survival. The aim of this study was to determine the relation of serum VEGF levels to the various indices of breast cancer and known tumor markers carcinoembryonic antigen and CA15.3.Preoperative serum VEGF levels were determined in 200 women with breast cancer and compared with serum VEGF levels in 88 healthy female controls.The serum VEGF levels of the cancer patients as a group were significantly elevated compared with those of the controls (P0.0005). VEGF levels were elevated in patients with invasive cancer of ductal/no specific type, ductal carcinoma in situ, and estrogen receptor (ER)-positive tumors. Patients with lobular carcinoma and ER-negative tumors had serum VEGF levels comparable with those in the controls. VEGF was more sensitive than CA15.3 and carcinoembryonic antigen in detecting breast cancer.Preoperative serum VEGF detects breast cancer with a sensitivity of 62.1%. The relationship to cancer type and ER status may have future therapeutic implications. Additional long-term studies are required to determine the prognostic significance of serum VEGF.

Published
2001

25. Genetic changes in breast cancer detected by comparative genomic hybridisation

Author

R L, Loveday, J, Greenman, D L, Simcox, V, Speirs, P J, Drew, J R, Monson, and M J, Kerin

Subjects
Adult, Chromosome Aberrations, Gene Dosage, Humans, Nucleic Acid Hybridization, Breast Neoplasms, Female, Middle Aged, Aged
Abstract

Breast cancer is characterised by a number of genetic aberrations. Our purpose was to use comparative genomic hybridisation (CGH) to screen breast carcinomas for copy number changes: 44 ductal and 8 lobular carcinomas were studied and a large number of genetic aberrations identified. Many of these showed similarity to previous CGH results, however, a number of loci not previously shown to have undergone frequent change were identified. This included copy number gains affecting chromosomes 1p, 4q, 5q, 6q and 13q. Furthermore, we have identified 2 regions of copy number change, the gain on 5p and deletion of 16q, which correlated with lobular carcinomas. Our results highlight several areas of the genome that may be important in the molecular genetics of breast cancer.

Published
2000

26. Increased expression of estrogen receptor beta mRNA in tamoxifen-resistant breast cancer patients

Author

V, Speirs, C, Malone, D S, Walton, M J, Kerin, and S L, Atkin

Subjects
Male, DNA, Complementary, Antineoplastic Agents, Hormonal, Reverse Transcriptase Polymerase Chain Reaction, Breast Neoplasms, Middle Aged, Gene Expression Regulation, Neoplastic, Tamoxifen, Receptors, Estrogen, Drug Resistance, Neoplasm, Transforming Growth Factor beta, Case-Control Studies, Testis, Tumor Cells, Cultured, Estrogen Receptor beta, Humans, Female, RNA, Messenger, Aged
Abstract

Tamoxifen is currently the first-line therapy for treatment of hormone-dependent breast cancer. However, despite initial benefits, most patients eventually relapse. Two groups of patients were identified: (a) a tamoxifen-sensitive group (n = 8); and (b) a tamoxifen-resistant group (n = 9). Using reverse transcription-PCR, the relative expression of mRNA for both estrogen receptor (ER) beta and transforming growth factor beta1 was determined in each patient group and quantified against a known reference standard. ER-beta mRNA was significantly up-regulated in the tamoxifen-resistant group as compared with the tamoxifen-sensitive group (P = 0.001 by Fisher's exact test), and, consistent with previous findings, transforming growth factor beta1 was also up-regulated in the tamoxifen-resistant cohort (P = 0.02). The importance of ER-beta in tamoxifen resistance was validated using tamoxifen-sensitive and -resistant cell lines, in which it was demonstrated that ER-beta mRNA was significantly up-regulated in the resistant cells. These results lend further support to a role for ER-beta as a poor prognostic factor in breast cancer.

Published
1999

27. Genetic changes associated with telomerase activity in breast cancer

Author

R L, Loveday, J, Greenman, P J, Drew, J R, Monson, and M J, Kerin

Subjects
Chromosome Aberrations, Genes, myc, Humans, Breast Neoplasms, Female, Genes, p53, Telomerase, Chromosomes, Human, Pair 8
Abstract

Telomerase, the enzyme responsible for maintenance of the telomeres, is absent from the vast majority of somatic cells but is present in most tumours. Little is known about how telomerase is activated in cancer, although it is thought vital for immortalisation to occur. The aim of our study was to identify genetic changes associated with telomerase activity. Thirty-three breast carcinomas were assessed for telomerase activity using the PCR based TRAP assay, and genetic changes by comparative genomic hybridisation (CGH). Seventy-five percent of the tumours were telomerase positive, and these were further divided into low or high level telomerase activity groups. A large number of genetic aberrations were identified but 4 chromosomal regions were identified that correlated with the telomerase status of the tumour. Gain of 1q correlated with telomerase negative tumours, gain of 3q correlated with high level telomerase activity. Gain of 8q correlated with telomerase positive tumours and furthermore with high level telomerase activity; deletion of 17p also correlated with high level telomerase activity. CGH analysis of breast tumours in conjunction with telomerase status has supported early results suggesting the involvement of the telomerase hTR, c-myc and p53 genes in the control of telomerase activity. These genes are located on chromosomes 3q, 8q and 17p. Most importantly, our results have identified the involvement of gene(s) located on chromosome 1q in telomerase expression.

Published
1999

29. Optimal education techniques for basic surgical trainees: lessons from education theory

Author

P J, Drew, N, Cule, M, Gough, K, Heer, J R, Monson, P W, Lee, M J, Kerin, and G S, Duthie

Subjects
Adult, General Surgery, Surveys and Questionnaires, Teaching, Humans, Learning
Abstract

"Calmanisation" of surgical training and the introduction of the "New Deal" on doctor's hours has led to a reduction in "in service" training and a proliferation of training courses. Little research has been done into the optimum design of these courses. Education theory has shown that individuals have optimal learning styles and that these styles tend to be generalised across professional groups. It was decided, therefore, to investigate the optimal learning styles of basic surgical trainees. A learning style inventory was used to assess the preferred learning style of 52 basic surgical trainees. The predominant learning styles (86.5%) were convergent (n = 31) or accommodative (n = 14) whilst only 5 (9.6%) assimilative and 2 (3.9%) divergent styles were detected. Convergent and accommodative learners rely principally on hands on experience and problem solving as their optimal learning technique. Given the shorter hours and duration of Basic Surgical Training, in service practical training and surgical courses should be structured accordingly.

Published
1999

30. Coexpression of estrogen receptor alpha and beta: poor prognostic factors in human breast cancer?

Author

V, Speirs, A T, Parkes, M J, Kerin, D S, Walton, P J, Carleton, J N, Fox, and S L, Atkin

Subjects
Adult, Aged, 80 and over, Reverse Transcriptase Polymerase Chain Reaction, Estrogen Receptor alpha, Breast Neoplasms, Middle Aged, Prognosis, Receptors, Estrogen, Reference Values, Estrogen Receptor beta, Humans, Protein Isoforms, Female, Breast, Aged
Abstract

The cloning of a second estrogen receptor (ER), ER beta, has prompted a reevaluation of the role of ERs in breast cancer. The aim of this study was to determine the expression of both ER isoforms in normal (n = 23) and malignant (n = 60) human breast tissue by reverse transcription-PCR and correlate this information with known prognostic factors including tumor grade and node status. In normal breast tissue, expression of ER beta predominated, with 22% of samples exclusively expressing ER beta; this was not observed in any of the breast tumor samples investigated. Most breast tumors expressed ER alpha, either alone or in combination with ER beta. Interestingly, those tumors that coexpressed ER alpha and ER beta were node positive (P = 0.02; Fisher's exact test) and tended to be of higher grade. Because antiestrogens are agonists when signaling through the AP1 element, overexpression of ER beta in tumors expressing both ER subtypes may explain the failure of antiestrogen therapy in some breast cancer patients. Thus, ER beta may be a useful prognostic factor in patients with breast cancer.

Published
1999

31. Primary small intestinal tumours: increased incidence of lymphoma and improved survival

Author

C J, O'Boyle, M J, Kerin, K, Feeley, and H F, Given

Subjects
Adult, Aged, 80 and over, Male, Lymphoma, Non-Hodgkin, Adenocarcinoma, Middle Aged, Survival Rate, Intestinal Neoplasms, Intestine, Small, Humans, Female, Aged, Follow-Up Studies, Research Article
Abstract

Small intestinal malignancies are rare and may have a delayed presentation owing to insidious growth. We have reviewed the case notes of 25 patients presenting with primary small bowel tumours over a 10-year period. Abdominal pain, weight loss and vomiting were the most common symptoms. The median duration of symptoms was 6 months. Physical examination was normal in 24% of patients. An abdominal mass was present in 46% of cases. Emergency laparotomy was undertaken in 28% of patients. Lymphomas were identified in 72% and adenocarcinomas were present in 16%. The predominance of small bowel lymphoma is an unusual finding and may be related to the high incidence of coeliac disease in the region. The median survival in the lymphoma group was 36 months, which compares favourably with reported series.

Published
1998

33. Preoperative serum vascular endothelial growth factor can predict stage in colorectal cancer

Author

H, Kumar, K, Heer, P W, Lee, G S, Duthie, A W, MacDonald, J, Greenman, M J, Kerin, and J R, Monson

Subjects
Adult, Male, Vascular Endothelial Growth Factor A, Analysis of Variance, Lymphokines, Vascular Endothelial Growth Factors, Liver Neoplasms, Endothelial Growth Factors, Prognosis, Neoplasm Proteins, Humans, Female, Colorectal Neoplasms, Neoplasm Staging
Abstract

Neovascularization has been shown to be essential for the growth of solid tumors. Vascular endothelial growth factor (VEGF) is one of the most important mediators of angiogenesis. This study was conducted to determine the significance of this cytokine as a tumor marker for staging colorectal cancer. Preoperative serum VEGF was measured in 108 colorectal cancer patients and in 136 normal healthy controls. The results of this study showed a significant difference between the four T classes, Union International Contre Cancer (UICC) stages, and Dukes' stages. In comparison to serum levels in controls (median, 173.8 pg/ml), VEGF levels were significantly elevated in T2 (P = 0.003), T3, and T4 (P0.0005); UICC I (P = 0.001), UICC II, UICC III, and UICC IV (P0.0005); and Dukes' A (P = 0.001), Dukes' B, and Dukes' C (P0.0005). Serum VEGF showed a significant elevation over control in node-negative (P0.0005) and in node-positive colorectal cancer (P0.0005) patients. Node-positive cancer had a significant elevation of serum VEGF compared to node-negative cancer (P = 0.008). This study reveals that preoperative serum VEGF can detect all but very early colorectal cancer i.e., T1 (P = 0.06).

Published
1998

34. A prospective evaluation of CA15-3 in stage I carcinoma of the breast

Author

D M, O'Hanlon, M J, Kerin, P J, Kent, R, Skehill, D, Maher, H, Grimes, and H F, Given

Subjects
Adult, Aged, 80 and over, Mucin-1, Bone Neoplasms, Breast Neoplasms, Middle Aged, Prognosis, Predictive Value of Tests, Biomarkers, Tumor, Humans, Female, Prospective Studies, Neoplasm Recurrence, Local, Aged, Neoplasm Staging
Abstract

Carcinoma of the breast is characterized by a variable course with prognosis dependent on disease stage at presentation. Paradoxically, some patients with early malignancy demonstrate disease progression within a short time. The role of tumor markers in the management of carcinoma of the breast is controversial. While CA15-3 is the most widely used tumor marker in carcinoma of the breast, its role in the management of patients with early disease is controversial.Since 1986, all patients presenting to our unit with carcinoma of the breast have had serial CA15-3 levels measured. This study evaluates the role of serial CA15-3 levels in the management of a consecutive series of 168 patients with Stage I disease at presentation.The mean preoperative CA15-3 levels at presentation were significantly elevated in patients with Stage I disease compared with patients with benign disease. Sixteen patients had either locoregional (five patients) or metastatic recurrence (11 patients). CA15-3 levels were not elevated in patients with locoregional disease and were significantly elevated in patients with bony metastases and gave a mean lead time of 6.3 months over bone scintigraphy.Serial CA15-3 measurements are an efficient and cost-effective method of monitoring disease progression and have advantages over conventional investigations in patients with early carcinoma of the breast.

Published
1995

36. Comparison of three methods for measuring cigarette smoking in patients with vascular disease

Author

K T, Galvin, M J, Kerin, G, Williams, K L, Gorst, R H, Morgan, and R C, Kester

Subjects
Male, Carboxyhemoglobin, Risk Factors, Smoking, Methods, Humans, Female, Vascular Diseases, Carbon Dioxide, Middle Aged, Sensitivity and Specificity, Thiocyanates, Aged
Abstract

Although smoking has been identified as an independent risk factor in peripheral vascular disease, smokers do not accurately report their habit. Therefore, a cheap, non-invasive, objective method of measuring smoking behaviour in vascular surgical units is desirable. The value of end-expiratory carbon monoxide monitoring, which is both simple and inexpensive, was compared with two well-established, validated techniques (serum thiocyanate and blood carboxyhaemoglobin levels). Some 33 surgical patients with peripheral vascular disease provided samples of expired air for measurement of carbon monoxide and blood for carboxyhaemoglobin and thiocyanate levels. Carboxyhaemoglobin was the most sensitive test (90%) and had a high specificity (100%). Expired carbon monoxide was the least sensitive (60%) but had a high specificity (100%). The carbon monoxide and carboxyhaemoglobin levels correlated significantly (r = 0.829; P = 0.0001). Serum thiocyanate was relatively sensitive (80%) but had a lower specificity (70%). Conventional methods for assessing smoking behaviour have not gained widespread use because they are time-consuming, relatively invasive and require technical support. Non-invasive measurement of carbon monoxide gives immediate accurate results and is a useful inexpensive method for measuring cigarette smoking in patients attending a follow-up vascular unit.

Published
1994

37. Seventeenth sir peter freyer memorial lecture and surgical symposium

Author

D. O’Gradaigh, P. J. Byrne, P. Gillen, P. Lawlor, T. N. Walsh, T. P. J. Hennessy, S. T. O’Sullivan, G. C. O’Sullivan, W. O. Kirwan, H. Li, M. T. P. Caldwell, S. Hone, S. E. A. Attwood, I. P. Kelly, T. P. Corrigan, E. Mulligan, M. J. Kerin, N. N. Williams, K. J. Cronin, M. El Sadar, P. Dervan, J. M. Fitzpatrick, T. F. Gorey, M. Maher, D. Hehir, A. Horgan, R. Stuart, J. A. O’Donnell, M. P. Brady, J. M. O’Donoghue, J. R. Flynn, J. Doyle, M. Gallagher, K. Connolly, M. Barry, M. G Davies, M. West, E. O’Broin, J. A. Connolly, D. Long, M. F. Shine, F. Lennon, K. J. Dawson, J. R. Novell, A. K. Burroughs, K. Rolles, W. P. Joyce, J. Dolan, J. Hyland, O. Traynor, M. Bennett, O. Tighe, H. Mulcahy, D. O’Donoghue, D. Bouchier-Hayes, D. T. Croke, G. Santos, G. Khoury, M. C. Winslet, A. A. M. Lewis, E. Beausang, K. Mealy, L. Joyce, M. McNicholls, D. McErlean, M. A. Stokes, K. Barry, R. Sullivan, J. Byrne, J. Callaghan, T. O’Gorman°, H. F. Given, M. S. Dudeney, M. P. Redmond, J. M. Deasy, V. K. Young, R. G. K. Watson, G. O’Kane, K. Murphy, C. McDowell, K. Khan, S. K. Al-Ghazal, J. McCann, R. C. Stuart, M. O’Connor, J. McCabe, J. O’Byrne, D. O’Farrell, M. Walsh, J. O’Beirne, S. O’Flannagan, A. McGuinness, O. Brady, W. Quinlan, J. P. McCabe, B. Curtin, M. Stephens, J. Stack, P. McCarthy, M. Schnall, H. Pollack, T. H. Lynch, B. Waymont, J. A. Dunn, M. A. Hughes, D. M. A. Wallace, T. E. D. McDermott, R. Grainger, E. Rogers, M. Corcoran, H. Bredin, H. Grimes, D. Lanigan, C. Roobottom, P. A. Dubbins, R. G. Choa, T. Creagh, M. R. Butler, K. J. O’Flynn, R. P. MacDonagh, D. G. Thomas, K. Dawson, J. Aitken, B. Cooke, S. P. Parbhoo, P. M. Cannon, S. C. Low, A. Dixon, I. O. Ellis, C. W. Elston, R. W. Blarney, E. D. Mulligan, K. Cronin, A. Stack, J. Ennis, F. Abbaskoor, M. K. O’Donoghue, G. Fulton, W. A. Tanner, F. B. V. Keane, B. V. Joseph, F. O. Cunningham, M. Dowling, E. Conveney, J. G. Geraghty, P. Byrne, G. Clarke, J. Duffy, N. O’Higgins, D. O’Hanlon, P. G. Horgan, D. O’Brien, C. Phelan, P. Given, P. Kent, S. Sheehan, M. P. Colgan, D. Moore, G. Shanik, P. Murphy, R. Vashisht, M. Sian, P. Franks, M. K. O’Malley, Y. Gul, D. Waldron, W. P. Hederman, H. P. Singh, S. Dias, T. Aherne, D. J. Hehir, J. A. McKeever, C. A. Bannon, D. Mehigan, T. V. Keaveney, T. F. Browne, U. M. Sivananthan, M. R. Rees, S. Whittaker, G. A. Davies, R. Vashisght, E. Sharp, A. Coady, A. Sterpetti, R. M. Greenhalgh, D. P. O’Brien, D. B. Gough, M. C. Regan, I. E. Efron, S. I. Kirk, M. Hurson, H. L. Wasserkrug, A. Barbul, S. Haynes, J. Thornton, J. Sparkes, A. D. K. Hill, C. J. Kelly, J. Gallagher, L. Modyka, H. P. Redmond, J. M. Daly, O. M. Austin, R. J. Cunney, P. A. Grace, C. Curran, J. O’Donoghue, M. Abernathy, N. Sharpe, M. Lucy, E. W. D. McDermott, P. M. Mercer, N. J. O’Higgins, G. Murugasu, A. Groeschel, M. Carmody, J. Donohue, D. H. Osborne, M. McLaughlin, J. Devlin, J. P. Phillips, Y. Ellias, M. Tahir, J. McKeever, M. Tighe, V. Lynch, M. Ahmed, P. P. A. Smyth, A. M. Hetherton, P. Horgan, M. Little, D. S. Quill, C. O. Duncan, M. O’Donnell, J. A. E. Hobby, D. Little, M. Murphy, P. Burke, P. Broe, M. McKiernan, S. J. Kirk, J. Crowe, P. MacMathuna, J. Lennon, T. Corrigan, R. O’Connell, A. Browne, A. Quershi, A. Leahy, G. Courtney, P. Grace, H. Osborne, D. J. Buckley, M. Goggin, T. A. Farrell, J. Geraghty, F. K. Keeling, P. R. O’Connell, H. Naama, E. Moore, E. Barry, C. Duffy, P. Hogan, G. Nee, M. Fahy, D. P. Kenny, V. Ellias, E. Gibney, W. Joyce, E. Gaffney, J. McMahon, M. McCabe, P. Kelly, M. Leader, C. I. Timon, P. Gullane, I. Dardick, I. McCarthy, N. F. Couse, M. Morrin, and P. V. Delaney

Subjects
General Medicine
Published
1994

38. Diagnostic pitfalls of fine needle aspiration cytology for breast disease

Author

M J, Kerin, O J, McAnena, R P, Waldron, M, McGuire, and H F, Given

Subjects
Biopsy, Needle, Carcinoma, Ductal, Breast, Humans, Breast Neoplasms, False Positive Reactions, Female, Neoplasm Invasiveness, Diagnostic Errors, False Negative Reactions, Ireland, Carcinoma in Situ, Mastectomy
Abstract

We analysed 1500 consecutive fine needle aspiration cytology (FNAC) specimens to ascertain the reasons for diagnostic failure. Of 221 tumours proven malignant following open biopsy, 184 (83%) were correctly diagnosed on FNAC. Of 1082 aspirates classified 'benign', 787 (73%) underwent open biopsy and of these 33 (4%) were diagnosed malignant. All three cases of ductal carcinoma in-situ (DCIS) and eight of 16 lobular carcinomas in this study were missed using FNAC alone. Twelve of the 22 patients with invasive carcinoma not diagnosed on cytology had tumours measuring less than 1 cm diameter. Six of 1500 FNAC reports (0.4%) gave false positive diagnoses, five were classified as 'suspicious of malignancy; and one as 'frankly malignant'. The overall sensitivity was 84%, specificity 99% and positive predictive value 97%. Though these results confirm the value of FNAC as a rapid means of diagnosing most breast cancers, it it unreliable in patients with invasive carcinomas less than 1 cm in diameter and for the detection of lobular and in-situ carcinoma.

Published
1993

39. Preventable perioperative mortality from colorectal cancer

Author

M J, Kerin, D, O'Farrell, R P, Waldron, and J G, Johnson

Subjects
Male, Liver Neoplasms, Humans, Female, Hospital Mortality, Colorectal Neoplasms, Aged
Abstract

Of 271 patients with primary colorectal cancer, 70 (26%) had detectable hepatic metastases. A primary tumour resection was possible for 225 (83%) of patients overall. Of the 46 patients with non resectable tumours, 38 (82%) had hepatic metastases. 23 (33%) of the patients with Dukes' D tumours died perioperatively relative to 13 (6%) of those with localised tumours (p.001). Seventeen (70%) of the twenty three patients with Dukes' D cancers who died perioperatively had locally advanced disease but were not obstructed and had neither a resection or a stoma performed. Perioperative mortality is unacceptably high in patients with hepatic metastases but may be reduced by more specialised investigation of patients with suspected advanced disease to assess the degree of local dissemination and liver seeding prior to considering laparotomy.

Published
1993

41. Combined endoscopic cytology and biopsies in the diagnosis of duodenal malignancy

Author

A J, King, J, McCabe, M, Waldron, M J, Kerin, M, McGuire, and H F, Given

Subjects
Male, Duodenal Neoplasms, Biopsy, Cytodiagnosis, Humans, Female, Duodenoscopy
Abstract

The value of combined cytohistochemical examination in the diagnosis of malignant duodenal lesions was assessed in 78 patients with suspicious duodenal lesions seen at endoscopy. Cytological smears were taken using the direct-vision brushing technique and all were processed by the same experienced cytologist. Duodenal malignancy was confirmed histologically in four patients. Endoscopic biopsy was positive for malignancy in three of the patients and cytology was suspicious of malignant change in two patients and positive for malignant change in one patient. Cytology alone confirmed the diagnosis of malignancy in one patient. The cumulative diagnostic yield using both biopsy and cytology was 100%.

Published
1990

42. Oncology

Author

D. A. Browell, J. A. Kirby, K. Gilmore, B. K. Shenton, T. W. J. Lennard, D. J. A. Orr, L. E. Hughes, K. Horgan, A. Darzi, R. Goldin, P. J. Guillou, J. R. T. Monson, M. J. Dworkin, S. Earlam, T. G. Allen-Mersh, M. J. Kerin, E. Mulligan, N. N. Williams, K. J. Cronin, P. Dervan, J. M. Fitzpatrick, T. F. Gorey, D. H. Reinbach, J. R. McGregor, P. J. O’Dwyer, J. V. Reynolds, N. Nolan, A. McCann, M. J. Duffy, E. W. M. McDermott, and N. J. O’Higgins

Subjects
General Medicine
Published
1992

43. Rupture of False Aneurysm Secondary to Passage of Ureteric Stent

Author

M. J. Kerin, H. J. Jaeger, G. H. Kruegener, and J. MacFIE

Subjects
Male, medicine.medical_specialty, Urology, medicine.medical_treatment, Hydronephrosis, urologic and male genital diseases, Iliac Artery, Aneurysm, Ureter, medicine, Humans, cardiovascular diseases, Ureteric stent, Aged, Rupture, Iliac artery, business.industry, nutritional and metabolic diseases, medicine.disease, nervous system diseases, Surgery, surgical procedures, operative, medicine.anatomical_structure, Stents, Radiology, Complication, business, Ureteral Obstruction
Abstract

We report the first case of rupture of a false aneurysm of the iliac artery due to retrograde passage of a ureteric stent.

Published
1991

45. Royal Academy of Medicine in Ireland Surgical Section Proceedings of Registrars’ Prize Meeting, held on Friday, 15th April, 1988

Author

J. J. McCann, C. A. Vanderkolk, K. Knight, B. McC O’Brien, P. Gillen, P. A. Grace, M. McDermott, P. Dervan, J. M. Smith, J. M. Fitzpatrick, P. T. Cullen, F. C. Campbell, B. E. Storey, A. Cuschieri, P. D. Carey, T. M. Feeley, J. R. T. Monson, A. Darzi, F. B. Keane, W. A. Tanner, C. Shinkwin, W. O. Kirwan, M. Feely, G. Coughlan, Phillippa Marks, A. Gleeson, F. B. V. Keane, M. R. O’Donohoe, K. K. Ratnaval, E. J. Prendiville, F. O. Cunningham, E. W. M. McDermott, P. J. O’Dwyer, N. J. O’Higgins, E. Rogers, K. S. Cross, V. P. O’Malley, K. O’Malley, H. F. Given, P. Keeling, M. J. Kerin, O. J. McAnena, H. Grimes, G. M. Lennon, R. C. Stuart, T. F. Gorey, P. J. Byrne, P. Marks, and T. P. J. Hennessy

Subjects
medicine.medical_specialty, business.industry, Ophthalmology, Family medicine, medicine, General Medicine, business, Surgical section
Published
1988

46. Royal Academy of Medicine in Ireland Section of Sugery

Author

I. M. Reid, J. R. T. Monson, F. B. V. Keane, W. A. Tanner, A. Darzi, C. O’Morain, W. A. Taner, J. V. Reynolds, J. M. Daly, N. N. Williams, M. Herlyn, K. Moran, D. Kelly, S. Sheehan, P. Dervan, J. M. Fitzpatrick, S. J. Sheehan, P. A. Grace, K. T. Moran, D. J. Dowsett, J. P. Hurley, E. Tiernan, S. MacGowan, F. Lennon, W. P. Joyce, J. L. Provan, F. M. Ameli, P. McEwan, S. Jelenich, D. P. Jones, B. J. Jones, D. Fenton, P. Nowlan, H. P. Voorheis, P. C. Ryan, M. R. Butler, G. McEntee, K. McGeeney, R. C. Stuart, P. Marks, P. Lawlor, P. J. Byrne, T. F. Gorey, T. P. J. Hennessy, M. J. Kerin, J. Neilan, R. P. Waldron, O. J. McAnena, F. X. Gannon, and H. F. Given

Subjects
medicine.medical_specialty, business.industry, Ophthalmology, Section (typography), Medicine, Library science, General Medicine, business
Published
1989

47. Investigating the association of rs2910164 with cancer predisposition in an Irish cohort

Author

T P McVeigh, R J Mulligan, U M McVeigh, P W Owens, M Bell, F Sebag, C Guerin, D S Quill, J B Weidhaas, M J Kerin, and A J Lowery

Subjects
thyroid, endocrine cancers, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Introduction: MicroRNAs (miRNAs) are small noncoding RNA molecules that exert post-transcriptional effects on gene expression by binding with cis-regulatory regions in target messenger RNA (mRNA). Polymorphisms in genes encoding miRNAs or in miRNA–mRNA binding sites confer deleterious epigenetic effects on cancer risk. miR-146a has a role in inflammation and may have a role as a tumour suppressor. The polymorphism rs2910164 in the MIR146A gene encoding pre-miR-146a has been implicated in several inflammatory pathologies, including cancers of the breast and thyroid, although evidence for the associations has been conflicting in different populations. We aimed to further investigate the association of this variant with these two cancers in an Irish cohort. Methods: The study group comprised patients with breast cancer (BC), patients with differentiated thyroid cancer (DTC) and unaffected controls. Germline DNA was extracted from blood or from saliva collected using the DNA Genotek Oragene 575 collection kit, using crystallisation precipitation, and genotyped using TaqMan-based PCR. Data were analysed using SPSS, v22. Results: The total study group included 1516 participants. This comprised 1386 Irish participants; 724 unaffected individuals (controls), 523 patients with breast cancer (BC), 136 patients with differentiated thyroid cancer (DTC) and three patients with dual primary breast and thyroid cancer. An additional cohort of 130 patients with DTC from the South of France was also genotyped for the variant. The variant was detected with a minor allele frequency (MAF) of 0.19 in controls, 0.22 in BC and 0.27 and 0.26 in DTC cases from Ireland and France, respectively. The variant was not significantly associated with BC (per allele odds ratio = 1.20 (0.98–1.46), P = 0.07), but was associated with DTC in Irish patients (per allele OR = 1.59 (1.18–2.14), P = 0.002). Conclusion: The rs2910164 variant in MIR146A is significantly associated with DTC, but is not significantly associated with BC in this cohort.

Published
2017
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