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Your search keyword '"M. I. Gonçalves"' showing total 3 results
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3 results on '"M. I. Gonçalves"'

1. Study protocol to investigate biomolecular muscle profile as predictors of long-term urinary incontinence in women with gestational diabetes mellitus

Author

Marilza V. C. Rudge, Fátima P. Souza, Joelcio F. Abbade, Raghavendra L. S. Hallur, João Paulo C. Marcondes, Fernanda Piculo, Gabriela Marini, Giovana Vesentini, Lehana Thabane, Steven S. Witkin, Iracema M. P. Calderon, Angélica M. P. Barbosa, The Diamater Study Group, M. V. Rudge, A. M. P. Barbosa, I. M. P. Calderon, F. P. Souza, J. F. Abbade, L. S. R. Hallur, F. Piculo, G. Marini, G. Vesentini, L. Thabane, M. S. Palma, C. F. O. Graeff, R. K. Arni, R. D. Herculano, D. F. Salvadori, S. Mateus, M. Dal Pai Silva, C. G. Magalhães, R. A. Costa, S. A. M. Lima, S. L. Felisbino, W. Barbosa, A. Atallah, M. J. B. Girão, Z. Di Bella, S. M. Uchoa, S. Payão, A. Hijas, B. Berghman, R. De Bie, L. Sobrevia, B. Junginger, F. C. B. Alves, P. S. Rossignoli, C. B. Prudencio, M. I. G. Orlandi, M. I. Gonçalves, S. K. Nunes, B. B. Catinelli, S. Quiroz, B. V. Sarmento, F. A. Pinheiro, C. I. Sartorão, R. R. Lucas, D. R. A. Reyes, S. B. C. V. Quiroz, E. M. A. Enriquez, R. G. Oliveira, J. F. Floriano, J. P. C. Marcondes, S. Barneze, T. D. Dangió, T. Pascon, P. Rossignoli, J. V. Freitas, L. Takano, F. Reis, T. D. Caldeirão, J. N. Fernandes, A. M. Carr, M. V. C. Gaitero, J. E. Corrente, H. R. C. Nunes, A. F. Candido, S. M. B. Costa, J. V. F. Melo, F. V. D. S. Reis, G. A. Garcia, G. B. Rabadan, H. C. M. Bassin, K. S. Suyama, L. N. Damasceno, M. L. S. Takemoto, M. D. Menezes, D. G. Bussaneli, V. K. C. Nogueira, P. R. Lima, I. O. Lourenço, J. Marostica de Sá, R. A. Megid, I. P. Caruso, L. T. Rasmussen, G. M. Prata, M. A. Arantes, G. A. R. Ferraz, L. P. Camargo, and M. R. Kron

Subjects
Gestational diabetes mellitus, Hyperglycemic myopathy, Pelvic floor muscles, Rectus abdominis muscles, Urinary incontinence, Proteomics, Gynecology and obstetrics, RG1-991
Abstract

Abstract Background Pelvic floor muscles (PFM) and rectus abdominis muscles (RAM) of pregnant diabetic rats exhibit atrophy, co-localization of fast and slow fibers and an increased collagen type I/III ratio. However, the role of similar PFM or RAM hyperglycemic-related myopathy in women with gestational diabetes mellitus (GDM) remains poorly investigated. This study aims to assess the frequency of pelvic floor muscle disorders and pregnancy-specific urinary incontinence (PS-UI) 12 months after the Cesarean (C) section in women with GDM. Specifically, differences in PFM/RAM hyperglycemic myopathy will be evaluated. Methods The Diamater is an ongoing cohort study of four groups of 59 pregnant women each from the Perinatal Diabetes Research Centre (PDRC), Botucatu Medical School (FMB)-UNESP (São Paulo State University), Brazil. Diagnosis of GDM and PS-UI will be made at 24–26 weeks, with a follow-up at 34–38 weeks of gestation. Inclusion in the study will occur at the time of C-section, and patients will be followed at 24–48 h, 6 weeks and 6 and 12 months postpartum. Study groups will be classified as (1) GDM plus PS-UI; (2) GDM without PS-UI; (3) Non-GDM plus PS-UI; and (4) Non-GDM without PS-UI. We will analyze relationships between GDM, PS-UI and hyperglycemic myopathy at 12 months after C-section. The mediator variables to be evaluated include digital palpation, vaginal squeeze pressure, 3D pelvic floor ultrasound, and 3D RAM ultrasound. RAM samples obtained during C-section will be analyzed for ex-vivo contractility, morphological, molecular and OMICS profiles to further characterize the hyperglycemic myopathy. Additional variables to be evaluated include maternal age, socioeconomic status, educational level, ethnicity, body mass index, weight gain during pregnancy, quality of glycemic control and insulin therapy. Discussion To our knowledge, this will be the first study to provide data on the prevalence of PS-UI and RAM and PFM physical and biomolecular muscle profiles after C-section in mothers with GDM. The longitudinal design allows for the assessment of cause-effect relationships between GDM, PS-UI, and PFMs and RAMs myopathy. The findings may reveal previously undetermined consequences of GDM.

Published
2020
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2. Genital schistosomiasis mansoni concomitant to genital tumor in areas of low endemicity: challenging diagnosis

Author

Marta G, Cavalcanti, Margareth M I, Gonçalves, Magali M, Barreto, Aline Helen da, Silva, Kalil, Madi, José Mauro, Peralta, and Ricardo P, Igreja

Subjects
Adult, Feces, Schistosomicides, Animals, Humans, Female, Ovarian Diseases, Schistosoma mansoni, Parasite Egg Count, Schistosomiasis mansoni
Abstract

Genital infection by Schistosoma mansoni is usually misdiagnosed in individuals who reside in, or travel to endemic areas. We describe two cases of genital tumor associated with S. mansoni infection manifested by methrorragy. Surgical specimens revealed leiomyomas in both cases associated with S. mansoni. In one of them, granulomas were found in the ovary and in the other they were found in the uterine tube. Although none presented intestinal/hepatic disease, fecal egg excretion was detected in one. Both had elevated pretreatment antibody reactivity to S. mansoni antigen, but follow-up showed different outcomes. Schistosomiasis should be considered as a diagnosis in individuals with methrorragy residing in or having traveled to endemic areas. Since diagnosis follows genital amputation, and cure control is troublesome, improvement of diagnostic tools and follow-up markers are important priorities to decrease schistosomiasis morbidity.

Published
2009

3. Diagnosis of bacterial meningitis and septicemia by serum counterimmunoelectrophoresis

Author

M G, Alkmin, I M, Landgraf, M F, Vieira, M C, Camargo, and M I, Gonçalves

Subjects
Antigens, Bacterial, Counterimmunoelectrophoresis, Sepsis, Humans, Neisseria meningitidis, Meningitis, Bacterial, Retrospective Studies
Abstract

We compare the results obtained by counterimmunoelectrophoresis in samples of serum and cerebrospinal fluid with microbiologic methods for 3,298 patients suspected of bacterial meningitis and/or septicemia at Instituto Adolfo Lutz, São Paulo, in a retrospective study of the period from July 1998 to July 1994. Of the 415 patients (12.6% of the total cases studied) who were positive by the serum test, only 249 (7.6% of the total cases studied) were also positive when cerebrospinal fluid was assayed. Thus, 40% of the positives (5.6% of the total) were identifiable by analysis of serum but not of cerebrospinal fluid. Neisseria meningitidis accounted for 77.7% (129) and Haemophilus influenzae for 22.3% (37) of the positive results obtained only when serum was examined. These data show that although sensitivity and specificity of serum counterimmunoelectrophoresis are relatively low compared to cerebrospinal fluid counterimmunoelectrophoresis, the serum test is necessary to complement cerebrospinal fluid counterimmunoelectrophoresis data.

Published
1995

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