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Your search keyword '"M. G. Bruzzone"' showing total 6 results
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6 results on '"M. G. Bruzzone"'

1. P1359: USING GENE-MODIFIED AUTOLOGOUS STEM CELLS PROGENY TO REEDUCATE THE TUMOR IMMUNE MICROENVIRONMENT OF SOLID TUMORS (TEM-GBM STUDY)

Author

F. Farina, B. Gentner, M. Eoli, G. Finocchiaro, A. Capotondo, V. Cuccarini, M. M. Naldini, M. Barcella, E. Anghileri, V. Brambilla, M. G. Bruzzone, M. Carrabba, G. D’Alessandris, F. Di Meco, V. Ferla, A. Franzin, P. Ferroli, F. Gagliardi, F. Legnani, S. Mazzoleni, P. Mortini, A. Olivi, R. Pallini, M. Patanè, R. Paterra, B. Pollo, M. Saini, S. Snider, L. Naldini, C. Russo, and F. Ciceri

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2022
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2. CLIN-IMMUNOTHERAPY/BIOLOGIC THERAPIES

Author

I. F. Pollack, R. I. Jakacki, L. Butterfield, H. Okada, Y. Chiba, N. Hashimoto, N. Kagawa, M. Kinoshita, N. Kijima, R. Hirayama, Y. Oji, A. Tsuboi, Y. Oka, H. Sugiyama, T. Yoshimine, R. D. Valle, S. Tejada, S. Inoges, M. A. Idoate, A. L. D. de Cerio, J. Espinos, J. Aristu, J. Gallego, J. P. Calvo, M. Bendandi, J. Zhu, C. Chen, A. Ravelo, E. Yu, R. Dhanda, I. D. Schnadig, L. Zhang, H. Fan, I. Zhang, X. Chen, H. Wang, A. Da Fonseca, B. Badie, L. H. Butterfield, R. L. Hamilton, A. H. Mintz, J. A. Engh, J. Drappatz, M. O. Lively, M. D. Chan, A. M. Salazar, D. M. Potter, E. G. Shaw, F. S. Lieberman, J. Wei, L.-Y. Kong, F. Wang, S. Xu, T. A. Doucette, S. D. Ferguson, Y. Yang, K. McEnery, K. Jethwa, O. Gjyshi, W. Qiao, F. F. Lang, G. Rao, G. N. Fuller, G. A. Calin, A. B. Heimberger, S. Yang, G. E. Archer, H. Miao, X. Cui, W. Xie, D. Snyder, A. J. Pretorian, A. Dechkovskaia, E. Reap, L. A. S. Perez, P. Norberg, R. Schmittling, D. A. Mitchell, J. H. Sampson, F. Lang, G. Calin, D. G. Walker, T. Crough, L. Beagley, C. Smith, L. Jones, R. Khanna, Y. Kanemura, M. Sumida, E. Yoshioka, A. Yamamoto, D. Kanematsu, Y. Matsumoto, H. Fukusumi, A. Takada, M. Nonaka, S. Nakajima, K. Mori, S. Goto, T. Kamigaki, R. Maekawa, T. Shofuda, S. Moriuchi, M. Yamasaki, J. T. Yeung, R. Hamilton, R. Jakacki, I. Pollack, S. Pellegatta, M. Eoli, C. Antozzi, S. Frigerio, M. G. Bruzzone, L. Cuppini, S. Nava, E. Anghileri, G. Cantini, E. Prodi, E. Ciusani, P. Ferroli, M. Saini, G. Broggi, R. Mantegazza, E. A. Parati, G. Finocchiaro, M. Hegde, A. Corder, K. K. Chow, M. Mukherjee, V. S. Brawley, H. E. Heslop, S. Gottschalk, E. Yvon, N. Ahmed, D. M. Gibo, W. Debinski, J. Bonomo, J. Rossmeisl, J. Robertson, P. Dickinson, M. E. Salacz, P. J. Camarata, M. Ots, J. McIntire, D. Lovick, G. Archer, D. Bigner, H. Friedman, D. Lally-Goss, B. Perry, J. Herndon, S. McGehee, R. McLendon, R. E. Coleman, J. Sampson, Z. Grada, T. Byrd, D. R. Shaffer, A. Ghazi, K. Schonfeld, G. Dotti, H. Heslop, W. Wels, M. L. Baker, J. M. Robbins, P. J. Dickinson, D. York, B. K. Sturges, B. Martin, R. J. Higgins, J. Bringas, K. Bankiewicz, H. E. Gruber, D. J. Jolly, A. Narayana, M. Mathew, R. Kannan, K. Madden, J. Golfinos, E. Parker, P. Ott, A. Pavlick, D. A. Bota, C. Pretto, P. Hantos, F. M. Hofman, T. C. Chen, J. A. Carrillo, V. E. Schijns, A. A. Stathopoulos, R. M. Prins, R. Everson, H. Soto, D. N. Lisiero, E. Young, L. M. Liau, A. Friedman, D. D. Bigner, D. Boczkowski, S. G. Gururangan, G. Grant, T. Driscoll, J. King, S. Nair, H. Fuchs, J. Kurtzberg, M. A. Shevtsov, A. V. Pozdnyakov, A. V. Kim, K. A. Samochernych, I. V. Guzhova, I. V. Romanova, B. A. Margulis, and W. A. Khachatryan

Subjects
Abstracts, Cancer Research, Oncology, business.industry, medicine.medical_treatment, Biologic therapies, Medicine, Neurology (clinical), Immunotherapy, Bioinformatics, business
Published
2012
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3. CT and MRI of brain tumors

Author

M G, Bruzzone, L, D'Incerti, L L, Farina, V, Cuccarini, and G, Finocchiaro

Subjects
Brain Neoplasms, Brain, Humans, Image Enhancement, Tomography, X-Ray Computed, Magnetic Resonance Imaging
Abstract

Imaging plays a crucial role in the management of patients with brain tumors. The technical improvement of computed tomography (CT) and magnetic resonance (MRI) with the development of, new imaging techniques strongly improved the detection and characterization of brain tumors. For the optimal therapeutic management of the oncologic patient not only the recognition of the lesion is needed, but also the exclusion of other diseases that can mimic brain tumors. The preoperative assessment of malignancy and of relationships of the tumor with surrounding eloquent structures are also necessary to allow the correct choice of therapy and to warn surgeons of possible risks of the surgical approach. This article is an overview of the current state of neuroimaging of the most frequent brain tumors including CT and MRI, perfusion weighted imaging (PWI), diffusion weighted imaging (DWI), diffusion tensor imaging (DTI), proton magnetic resonance spectroscopy (1H-MRS) and functional MRI based on blood oxygen level (fMRI BOLD). Indeed, in the last years, a transition took place from a purely anatomy-based radiology to one that incorporates functional, hemodynamic, metabolic, cellular, and cytoarchitectural alterations. Neuroimaging has evolved into a comprehensive diagnostic tool that allows the characterization of morphologic as well as biologic alterations to diagnose and grade brain tumors and to monitor and assess treatment response and patient prognosis.

Published
2012

4. IL-4 gene transfer for the treatment of experimental gliomas

Author

S, Benedetti, F, Di Meco, N, Cirenei, M G, Bruzzone, B, Pollo, N, Florio, L, Caposio, M P, Colombo, E, Cattaneo, and G, Finocchiaro

Subjects
Neurons, Brain Neoplasms, Gene Transfer Techniques, DNA, Neoplasm, Glioma, Embryo, Mammalian, Magnetic Resonance Imaging, Corpus Striatum, Recombinant Proteins, Cell Line, Rats, Rats, Sprague-Dawley, Retroviridae, Tumor Cells, Cultured, Animals, Female, Interleukin-4
Published
1999

5. Gene transfer of suicide genes for the treatment of malignant gliomas: efficacy, limitations, and perspectives for a combined immunotherapy

Author

S, Benedetti, F, Di Meco, B, Pollo, M G, Bruzzone, N, Cirenei, R, Spreafico, C L, Solero, G, Broggi, S, Di Donato, and G, Finocchiaro

Subjects
Cell Death, Gene Transfer Techniques, Genetic Therapy, Combined Modality Therapy, Thymidine Kinase, Gene Expression Regulation, Neoplastic, Mice, Animals, Humans, Simplexvirus, Immunotherapy, Interleukin-4, Ganciclovir, Cell Division
Abstract

The potential of gene therapy strategies for malignant gliomas that are based on retroviral-mediated transfer of a "suicide gene" such as Herpes Simplex Virus-thymidine kinase HSV-tk and subsequent treatment by a prodrug (ganciclovir, for example), has been emphasized by the promising results obtained by several groups. However, further experimental data as well as preliminary clinical results indicate that the low efficiency of retroviral-mediated gene transfer in vivo as well as difficulties for the diffusion of the prodrug inside the tumour mass can limit the efficacy of this form of gene therapy. To achieve a more effective limitation of tumour growth other approaches may be combined with the "suicide gene" strategy and the enhancement of the immunological response to the tumour by cytokine gene transfer is prominent among these approaches. The authors' experiments in nude mice confirm the antineoplastic role of IL-4 and encourage testing the effects of the simultaneous transfer of IL-4 and HSV-tk genes in immunocompetent animals.

Published
1997

6. Book review

Author

M. G. Bruzzone

Subjects
Psychiatry and Mental health, General Neuroscience, Neurology (clinical), Dermatology, General Medicine
Published
1996
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