1. Genome sequence, comparative analysis and population genetics of the domestic horse
- Author
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Elisa Magnani, Sarah Fryc, Teri L. Lear, James R. Mickelson, Evan Mauceli, Loren C. Skow, Tosso Leeb, Emmeline W. Hill, Ann-Christine Syvänen, Joy M. Raison, Snaevar Sigurdsson, S. Searle, J. Vogel, Leif Andersson, Robert C. Onofrio, Helmut Blöcker, Bhanu P. Chowdhary, Eric S. Lander, Teruaki Tozaki, Kerstin Lindblad-Toh, Ottmar Distl, Mariano Rocchi, Matthew M. Binns, Ted Sharpe, Claire M. Wade, Solomon G. Nergadze, Tara Biagi, Manuel Garber, T. Hasegawa, Sante Gnerre, Freyja Imsland, Anna Kiialainen, Maria Cecilia T. Penedo, Robert C. Edgar, M. F. Piras, Oliver A. Ryder, David L. Adelson, G. Della Valle, James N. MacLeod, Jerzy Jurka, Elena Giulotto, Gabriella Lindgren, June E Swinburne, K. H. Røed, James D. Murray, S. Pedroni, Terje Raudsepp, Jared White, S.J. Coleman, Monica Zoli, Michael C. Zody, Douglas F. Antczak, Jinze Liu, Mark Vaudin, Rebecca R. Bellone, Ernest Bailey, Gérard Guérin, Stephanie J. Valberg, Broad Institute [Cambridge], Harvard University [Cambridge]-Massachusetts Institute of Technology (MIT), Center for Human Genetic Research, Massachusetts General Hospital [Boston], Faculty of Veterinary Sciences, The University of Sydney, Dipartimento di Genetica e Microbiologia, Università di Pavia, Department of Medical Biochemistry and Microbiology, Uppsala University, Dipartimento di Biologia, Alma Mater Studiorum University of Bologna (UNIBO), Maxwell H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, University of Adelaide, University of Tampa, Helmholtz Centre for Infection Research (HZI), Institute of Animal Breeding and Genetics, University of Veterinary Medecine Hannover, 45 Monterey Drive, Institute of Genetics, University of Bern, Veterinary Genetics Laboratory, University of California, The Wellcome Trust Sanger Institute [Cambridge], Cornell University, Royal Veterinary College, Génétique Animale et Biologie Intégrative (GABI), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Equine Research Institute, Japan Racing Association, Animal Genomics Laboratory, School of Agriculture, Food Science and Veterinary Medicine, University College Dublin [Dublin] (UCD), Genetic Information Research Institute, Department of Medical Sciences, Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences (SLU), Department of Computer Science, College of Veterinary Medecine, University of Minnesota [Twin Cities], University of Minnesota System-University of Minnesota System, Population Health and Reproduction, School of Veterinary Medicine, Department of Genetics and Microbiology, Università degli studi di Bari, San Diego Zoo's Institute for Conservation Research, College of Veterinary Medicine, Texas A&M University System, Animal Health Trust (AHT), Department of Molecular Genetics, Laboratory of Racing Chemistry, Department of Biology, Massachusetts Institute of Technology (MIT)-Howard Hugues Medical Institute, Massachusetts Institute of Technology (MIT)-Harvard University [Cambridge], Howard Hugues Medical Institute-Massachusetts Institute of Technology (MIT), Università degli Studi di Pavia, Cornell University [New York], Department of Animal Bredding and Genetics, University of Minnesota [Twin Cities] (UMN), Università degli studi di Bari Aldo Moro (UNIBA), and Howard Hughes Medical Institute (HHMI)-Massachusetts Institute of Technology (MIT)
- Subjects
Genetics ,Whole genome sequencing ,0303 health sciences ,Multidisciplinary ,040301 veterinary sciences ,[SDV]Life Sciences [q-bio] ,Haplotype ,complete genome ,Chromosome ,04 agricultural and veterinary sciences ,sequencing ,Biology ,Genome ,horse ,0403 veterinary science ,03 medical and health sciences ,Horse genome ,Evolutionary biology ,Centromere ,evolution ,030304 developmental biology ,Segmental duplication ,Synteny - Abstract
A Horse Is a Horse, of Course The history of horse domestication is closely tied to the history of the human society. Wade et al. (p. 865 ) report on the sequencing and provide a single nucleotide polymorphism map of the horse ( Equus caballus ) genome. Horses are a member of the order perissodactyla (odd-toed animals with hooves). The analysis reveals an evolutionarily new centromere on equine chromosome 11 that displays properties of an immature but fully functioning centromere and is devoid of centromeric satellite sequence. The findings clarify the nature of genetic diversity within and across horse breeds and suggest that the horse was domesticated from a relatively large number of females, but few males.
- Published
- 2009
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