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131 results on '"M. Drlicek"'

1. Neocortical neurones may be targeted by immune attack in anti-Yo paraneoplastic syndrome

Author: V. Buxhofer-Ausch, Herbert Budka, M. Drlicek, Hans Lassmann, Romana Höftberger, Fahmy Aboul-Enein, and Wolfgang Kristoferitsch
Subjects: Pathology, medicine.medical_specialty, Histology, Neocortex, Central nervous system, Autoantibody, Biology, medicine.disease, Paraneoplastic cerebellar degeneration, Blotting western, Pathology and Forensic Medicine, medicine.anatomical_structure, Immune system, Neurology, Cerebral cortex, Physiology (medical), medicine, Adenocarcinoma, Neurology (clinical)
Published: 2008
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2. Überlegungen zu einem Verabschiedungsraum

Author: M. Drlicek and P. Kraml
Subjects: Pathology and Forensic Medicine
Abstract: Viele Patienten versterben in Krankenhausern oder Pflegeeinrichtungen. Es besteht daher die Notwendigkeit, sowohl fur den Sterbenden als auch fur die Angehorigen ein Umfeld zu schaffen, das einen wurdevollen Tod, aber auch anschliesend einen wurdevollen Abschied ermoglicht. Fur den Abschied und die Trauer der Angehorigen sollte ein besonderer Verabschiedungsraum vorhanden sein. Dieser Raum sollte eine moglichst neutrale Ausstattung erhalten und dennoch unterschiedlichen kulturellen und religiosen Bedurfnissen gerecht werden. Um den Abschied auch symbolisch vollziehen zu konnen, ist die Ausrichtung des Verstorbenen auf ein Licht (Fenster) von groser Bedeutung.
Published: 2006
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3. Fluorescent In Situ Hybridization on Isolated Tumor Cell Nuclei: A Sensitive Method for 1p and 19q Deletion Analysis in Paraffin-Embedded Oligodendroglial Tumor Specimens

Author: Karl Rössler, Ellen Gelpi, Michael Huemer, Herbert Budka, Peter F. Ambros, Reinhold Kleinert, Brigitte Gatterbauer, Peter Birner, Ingeborg Fischer, Johann Anton, A. Luegmayr, Hans Maier, Johannes A. Hainfellner, M. Drlicek, and Inge M. Ambros
Subjects: Cell Nucleus, Pathology, medicine.medical_specialty, Paraffin Embedding, Oligoastrocytoma, Brain Neoplasms, Oligodendroglioma, Brain tumor, Astrocytoma, DNA, Neoplasm, In situ hybridization, Biology, medicine.disease, Neuroblastic Tumor, Pathology and Forensic Medicine, Chromosomes, Human, Pair 1, Neuroblastoma, medicine, Humans, Oligodendroglial Tumor, Chromosome Deletion, Chromosomes, Human, Pair 19, In Situ Hybridization, Fluorescence, Neoplasm Staging
Abstract: In oligodendroglial neoplasms, losses of chromosomal material at 1p and 19q associate with chemosensitivity and prolonged survival. Thus, 1p/19q testing is increasingly proposed for use in brain tumor diagnosis and prognostic assessment. Fluorescent in situ hybridization (FISH) is a classic technique for investigation of 1p/19q status in paraffin-embedded tissues. A major limitation of this method is truncation of tumor cell nuclei complicating assessment of hybridization results. In our study, we analyzed 1p and 19q status in a series of 79 oligodendroglial neoplasms (49 oligodendrogliomas, 30 oligoastrocytomas, WHO: 57 Grade II, 22 Grade III tumors) and controls (gliotic brain tissue: n = 4, diffuse low-grade astrocytoma: n = 4) using FISH on isolated whole tumor cell nuclei, prepared as cytospin preparations, thus bypassing the problem of nuclear truncation. For interpretation of FISH results, we used consensus criteria as defined by the SIOP-Europe Neuroblastoma Study Group for analysis of peripheral neuroblastic tumors. FISH yielded interpretable results in 98.7% for 1p and 92.1% for 19q. Chromosome 1p/19q alterations comprised deletions (1p: 79.5%, 19q: 80%) and imbalances (1p: 11.5%, 19q: 12.9%). 1p aberrations were more frequent in oligodendroglioma than in oligoastrocytoma (100% versus 75.9%, P =.001). The frequency of 1p/19q alterations was not significantly different in WHO Grade II or Grade III tumors or in primary and recurrent tumors. We conclude that FISH on isolated cell nuclei, with application of the SIOP Europe Neuroblastoma consensus criteria, is a sensitive method for detection and interpretation of 1p and 19q aberrations in paraffin-embedded tissue specimens of oligodendroglial neoplasms.
Published: 2003
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4. Neuropathology and general autopsy findings in AIDS during the last 15 years

Author: G. Böhm, U. Setinek, A. Steurer, Felix Lintner, M. Drlicek, and Kurt A. Jellinger
Subjects: Adult, Male, Adolescent, Neuropathology, Opportunistic Infections, Pathology and Forensic Medicine, Cohort Studies, Cellular and Molecular Neuroscience, Acquired immunodeficiency syndrome (AIDS), Immunopathology, Cadaver, Pneumocystosis, Humans, Medicine, Child, Kaposi's sarcoma, Aged, Retrospective Studies, Acquired Immunodeficiency Syndrome, business.industry, Progressive multifocal leukoencephalopathy, Brain, Middle Aged, medicine.disease, Toxoplasmosis, Child, Preschool, Immunology, Female, Neurology (clinical), business, Encephalitis
Abstract: A retrospective study of 450 consecutive AIDS autopsy cases (397 males, 53 females; mean age at death 38.4 years) in Vienna, Austria, between 1984 and 1999 compares the central nervous system (CNS) findings in three cohorts: 1984-1992 (190 cases), 1993-1995 (162 cases) and 1996-1999 (98 cases, after introduction of triple antiretroviral therapy) and the relationship of CNS findings to systemic AIDS pathology in the latter two cohorts. In these two groups, following involvement of the lung (85% and 75%, respectively), the brain continued to be the second most frequently involved organ (decrease from 80% to 60%, respectively). Extracerebral protozoal (Pneumocystis carinii, toxoplasmosis), Mycobacterium avium complex, viral [e.g., cytomegalovirus (CMV)], multiple opportunistic organ and CNS infections, and Kaposi sarcoma significantly decreased over time. There was less decrease in fungal infections, while bacterial organ and CNS infections (except for mycobacteriosis), lymphomas, HIV-associated CNS lesions (around 30%), non HIV-associated changes (vascular, metabolic, etc.) and negative CNS findings (10-11%) remained unchanged. Nonspecific CNS changes (e.g., meningeal fibrosis) increased. Extracerebral pathology in subjects with advanced HIV-related CNS lesions showed more frequent but decreasing systemic bacterial and CMV infections than those with negative or nonspecific neuropathology, while other opportunistic and multiple organ infections and lymphomas showed no differences between both groups. In a cohort of drug abusers, HIV encephalitis, progressive multifocal leukoencephalopathy, bacterial infections, hepatic encephalopathy, and negative CNS findings were more frequent than in non-users who showed increased incidence of CMV, toxoplasmosis, or other opportunistic CNS infections, and nonspecific CNS findings; the frequency of lymphomas was similar in both drug abusers and non-users. Similar to a recent autopsy study from San Diego, these data suggest that despite the beneficial effects of modern antiretroviral combination therapy, involvement of the brain in AIDS subjects continues to be a frequent autopsy finding, while the increased incidence of HIV encephalitis in our small cohort of drug users was less than observed in other recent autopsy studies.
Published: 2000
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5. T cell-mediated paraneoplastic ganglionitis - An autopsy case

Author: G. Tucek, U. Setinek, M. Drlicek, Wolfgang Grisold, S. Urbanits, and A. Bodenteich
Subjects: Paraneoplastic Subacute Sensory Neuronopathy, Pathology, medicine.medical_specialty, T-Lymphocytes, T cell, Nerve Tissue Proteins, Autopsy, Pathology and Forensic Medicine, Lymphocytic Infiltrate, Cellular and Molecular Neuroscience, Fatal Outcome, Ganglia, Spinal, Humans, Paraneoplastic Polyneuropathy, Medicine, Lung cancer, Autoantibodies, business.industry, Respiratory disease, RNA-Binding Proteins, Histology, Middle Aged, medicine.disease, medicine.anatomical_structure, ELAV Proteins, Immunology, Female, Neurology (clinical), business, Sensory nerve
Abstract: A 57-year-old woman presented with subacute sensory, ataxic neuronopathy. Clinical investigation revealed a right-sided non-small-cell lung cancer. Serum investigation for specific antineuronal antibodies was negative. Histology showed T lymphocytic infiltrates in dorsal root ganglia. The observed histological pattern is similar to that described in antibody-positive cases. Thus, these findings suggest similar pathways in specific antineuronal antibody-negative and -positive cases of paraneoplastic subacute sensory neuronopathy.
Published: 2000
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6. Cortical areas abundant in extracellular matrix chondroitin sulphate proteoglycans are less affected by cytoskeletal changes in Alzheimer's disease

Author: Dirk Hausen, Th. Arendt, Gert Brückner, M. Drlicek, Wolfgang Härtig, and Kurt Brauer
Subjects: Male, Tau protein, Auditory cortex, Alzheimer Disease, Reference Values, medicine, Humans, Cytoskeleton, Aged, Aged, 80 and over, Cerebral Cortex, Amyloid beta-Peptides, biology, General Neuroscience, Perineuronal net, Neurodegeneration, Human brain, Middle Aged, Entorhinal cortex, medicine.disease, Extracellular Matrix, medicine.anatomical_structure, Chondroitin Sulfate Proteoglycans, Cerebral cortex, Neurofibrils, biology.protein, Female, Primary motor cortex, Neuroscience
Abstract: In the human brain, the distribution of perineuronal nets occurring as lattice-like neuronal coatings of extracellular matrix proteoglycans ensheathing several types of non-pyramidal neurons and subpopulations of pyramidal cells in the cerebral cortex is largely unknown. Since proteoglycans are presumably involved in the pathogenesis of Alzheimer's disease, we analysed the distribution pattern of extracellular chondroitin sulphate proteoglycans in cortical areas, including primary motor, primary auditory and several prefrontal and temporal association areas, in normal human brains and in those showing neuropathological criteria of Alzheimer's disease. In both groups, neurons with perineuronal nets were most numerous in the primary motor cortex (approximately 10% in Brodmann's area 4) and in the primary auditory cortex as a representative of the primary sensory areas. Their number was lower in secondary and higher order association areas. Net-associated pyramidal cells occurred predominantly in layers III and V in motor areas, as well as throughout lower parts of layer III in the primary auditory cortex and neocortical association areas. In the entorhinal cortex, net-associated pyramidal cells were extremely rare. In brains showing hallmarks of Alzheimer's disease, the characteristic patterns of hyperphosphorylated tau protein, stained with the AT8 antibody, largely excluded the zones abundant in perineuronal nets and neuropil-associated chondroitin sulphate proteoglycans. As shown in double-stained sections, pyramidal and non-pyramidal neurons ensheathed by perineuronal nets were virtually unaffected by the formation of neurofibrillary tangles even in severely damaged regions. The distribution patterns of amyloid B deposits overlapped but showed no congruence with that of the extracellular chondroitin sulphate proteoglycans. It can be concluded that low susceptibility of neurons and cortical areas to neurofibrillary changes corresponds with high proportions of aggregating chondroitin sulphate proteoglycans in the neuronal microenvironment.
Published: 1999
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7. Ganglionitis in paraneoplastic subacute sensory neuronopathy: A morphologic study

Author: W. Kristoferitsch, M. Drlicek, Julia Wanschitz, Herbert Budka, and Johannes A. Hainfellner
Subjects: Paraneoplastic Subacute Sensory Neuronopathy, Pathology, medicine.medical_specialty, Paraneoplastic Syndromes, Encephalomyelitis, Autonomic ganglion, CD8-Positive T-Lymphocytes, Small-cell carcinoma, Neuritis, Ganglia, Spinal, Biopsy, medicine, Humans, Ganglia, Autonomic, Aged, medicine.diagnostic_test, business.industry, medicine.disease, Immunohistochemistry, Ganglion, medicine.anatomical_structure, Sensation Disorders, Female, Neurology (clinical), business, Polyneuropathy, Sensory nerve
Abstract: A 69-year-old woman presented with subacute sensory neuropathy and autonomic dysfunction of 9 months' duration, associated with high serum titers of anti-Hu antibodies. A small cell carcinoma of the lung was diagnosed by biopsy. She died after cardiorespiratory arrest. At autopsy, spinal and autonomic ganglia showed subacute inflammation with diffuse endoneurial T-cell, B-cell, and plasma cell infiltration. The cytoplasm and nuclei of some ganglion neurons displayed IgG immunocytochemical positivity. CD8+ T cells were tightly attached to, and indented the cell surface of, IgG-positive and IgG-negative neurons. This observation suggests that both cytotoxic T-cell-mediated attack against neurons and humoral mechanisms play a role in paraneoplastic subacute sensory neuronopathy.
Published: 1997
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8. Cytomegalovirus infection of the brain in AIDS: a clinicopathological study

Author: Kurt A. Jellinger, A. Steuer, E. Wondrusch, U. Setinek, Wolfgang Grisold, Felix Lintner, and M. Drlicek
Subjects: Adult, Male, Pathology, medicine.medical_specialty, Congenital cytomegalovirus infection, medicine.disease_cause, Herpesviridae, Pathology and Forensic Medicine, Central nervous system disease, Cellular and Molecular Neuroscience, Betaherpesvirinae, Immunopathology, medicine, Ventriculitis, Humans, Acquired Immunodeficiency Syndrome, biology, business.industry, Brain, Middle Aged, medicine.disease, biology.organism_classification, Cytomegalovirus Infections, Immunology, Female, Neurology (clinical), Complication, business, Encephalitis
Abstract: Based on neuropathological findings, a retrospective case control study of 39 patients with acquired immune deficiency syndrome (AIDS) and confirmed cytomegalovirus (CMV) infection of the brain is presented. Since 1989, the incidence has increased progressively and, in 1994, CMV was the most frequent opportunistic central nervous system (CNS) infection. Of the patients with CMV infections of the brain 16 had one or more coexisting secondary opportunistic and/or tumorous lesions in the CNS. Cerebral involvement by CMV was more frequent in patients with multiple extracerebral organ infections, while 7 among the 39 reported cases showed isolated CMV infection of the brain. The evaluation of the clinical records of 21 patients revealed neuropsychiatric signs and symptoms in 10, while these were absent in 11. All of these patients revealed various types of cerebral lesions related to CMV infection: ventriculitis, focal lesions, and microglial nodule encephalitis. The extent and distribution of cerebral lesions showed no significant correlations with clinical, radiological, or laboratory findings. Further clinicopathological studies are warranted to recognize CMV infections of the CNS and to allow earlier and more efficient treatment of this rather frequent complication of AIDS.
Published: 1995
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9. Guidelines on the detection of paraneoplastic anti-neuronal-specific antibodies: Report from the Workshop to the Fourth Meeting of the International Society of Neuro-Immunology on paraneoplastic neurological disease, held October 22-23, 1994, in Rotterdam, The Netherlands

Author: Kurt A. Jaeckle, J.Y. Delattre, K. Tanaka, J.W.B. Moll, H. R. Brashear, M. Drlicek, J. Honnorat, Charles J. Vecht, Edward J. Dropcho, J. C. Antoine, Francesc Graus, John E. Greenlee, and B. Giometto
Subjects: Pathology, medicine.medical_specialty, biology, medicine.diagnostic_test, Paraneoplastic Syndromes, business.industry, Encephalomyelitis, Limbic encephalitis, Myelitis, Disease, medicine.disease, Antigen, Western blot, Immunology, medicine, biology.protein, Humans, Immunohistochemistry, Neurology (clinical), Antibody, business, Autoantibodies
Abstract: Paraneoplastic syndromes of the central nervous system (PNS) consist of a variety of neurologic disorders including encephalomyelitis (limbic encephalitis, brainstem encephalitis, and acute myelitis), sensory neuronopathy, subacute cerebellar degeneration, visual paraneoplastic syndrome, stiffman syndrome, and motor neuron disease. [1-3] For the clinician, it is often difficult to arrive at a reliable diagnosis of the neurologic syndrome and to detect the underlying tumor. Neurologic signs and symptoms, although often stereotypic, are not specific. In two-thirds of cases the underlying tumor is not discovered until after the first neurologic symptoms. [4] Furthermore, the neoplasm may be small and difficult to detect. [5-7] PNS are frequently associated with serum autoantibodies reactive with neuronal antigens that are also present in the underlying tumor. These antibodies include (1) the anti-Yo antibody, also called "type 1 anti-Purkinje cell antibody" (PCA-1), "APCA-1," or "type I antibody"; (2) the anti-Hu antibody, also called "type 1 anti-neuronal nuclear antibody" (ANNA-1) or "type IIa antibody"; and (3) the anti-Ri antibody, also called "type 2 anti-neuronal nuclear antibody" (ANNA-2) or "type IIb antibody" Table 1. A clinical diagnosis of PNS is supported by the finding of these specific anti-neuronal antibodies. The detection of these antibodies should also lead to a focused search for specific underlying neoplasms. [8-12] View this table: Table 1. Criteria for identification of paraneoplastic anti-neuronal antibodies A major problem in comparing results obtained by different groups of investigators has been that individual laboratories have employed different laboratory techniques for detection of these antibodies. Although identification of these antibodies has rested on immunohistochemistry and Western blot analysis, not all laboratories have used Western blot analysis to identify the molecular weight of detected antigens. Furthermore, material from a number of animal species has been used, methods of preparing substrates for Western blot are not always spelled out, and concentrations of serum and …
Published: 1995
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10. Fourth meeting of the European Neurological Society 25–29 June 1994 Barcelona, Spain

Author: H. Hattig, C. Delli Pizzi, M. C. Addonizio, Michelle Davis, A. R. Giovagnoli, L. Florensa, M. Roth, J. de Kruijk, Francisco Lacruz, Ph. Dewailly, A. Toygar, C. Avendano, P.P. De Deyn, J. F. Hurtevent, F. Lomeila, T. W. Wong, Gordon T. Plant, M. Bud, H. J. Willison, DH Miller, D. W. Langdon, R. Cioni, J. Servan, A. Kaygisiz, E. Racadot, D. B. Schens, E. Picciola, L. Falip, C. Bouchard, J. Jotova, A. Jorge-Santamaria, P. Misra, A. Dufour, C. P. Panagopoulos, A. Venneri, B. Sredni, B. Angelard, M. Janelidze, M. Carreno, J. Obenberger, J. Pouget, H. W. Moser, R. Kaufmann, J. A. Molina, D. Linden, A. Martin Urda, E. Uvestad, A. Krone, J. P. Cochin, J. Mallecourt, A. Cambon-Thomsen, K. Violleau, P. Osschmann, A. M. Durocher, E. Bussaglia, D. M. Danielle, H. Efendi, C. Van Broeckhoven, K. G. Jordan, W. Rautenberg, C. Iniguez, J. M. Delgado, Graham Watson, M. Lawden, Gareth J. Barker, K. Stiasny, James T. Becker, G. Campanella, E. Peghi, A. Poli, A. Haddad, T. Yamawaki, Giacomo P. Comi, S. Sotgiu, B. Ersmark, A. Pomes, M. Ziegler, P. Ferrante, P. Ruppi, H. KuÇukoglu, R. Bouton, U. K. Rinne, P. Vieregge, M. Dary, P. Giunti, Peter J. Goadsby, S. Jung, E. Secor, A. Steinberg, N. Vila, M. A. Hernandez, M. Cursi, A. Enqelhardt, A. Engelhardt, J. Veitch, F. Di Silverio, F. Arnaud, B. Neundörfer, R. Brucher, Dominique Caparros-Lefebvre, B. Meyer, Marianne Dieterich, M. H. Snidaro, R. Gomez, R. Cerbo, M. Ragno, J. M. Vance, S. Nemni, A. Caliskan, F. Barros, I. Velcheva, D. Ceballos-Baumann, V. Barak, A. Avila, N. Antonova, F. Resche, S. Pappata, L. Varela, S. R. Silveira Santos, A. Cammarota, L. Naccache, Y. Nara, E. Tournier-Lasserves, R. Mobner, T. Chase, A. Ensenyat, J. Ulrich, G. Giegerich, M. Rother, M. Revilla, N. Nitschke, K. Honczarenko, E. Basart Tarrats, J. Blin, B. Jacob, J. Santamaria, S. Knezevic, J. L. Castillo, M. Antem, J. Colomer, O. Busse, Didier Hannequin, S. Carrier, J. B. Ruidavets, C. Rozman, J. Bogoussslavsky, J. Pascual Calvet, E. Monros, J. M. Polo, M. Zucconl, Javier Muruzabal, R. R. Allen, R. Rivolta, K. Haugaard, A. Nespolo, K. Hoang-Xuang, G. Bussone, T. Avramidis, E. Corsini, Christiana Franke, T. Vinogradova, H. Boot, K. Vestergaard, G. H. Jansen, N. Argentino, M. Raltzig, W. Linssen, Mark B. Pepys, P. Roblot, L. Lauritzen, E. Fainardi, D. Morin, T. X. Arbizu Urdiain, J. Wollenhaupt, S. Bostantjopoulou, G. Pavesi, A. D. Forman, Giovanni Fabbrini, D. Jean, J. J. Archelos, M. I. Blanchs, M. Del Gobbo, Anna Carla Turconi, Ch. Derouesné, Elio Scarpini, A. Visbeck, P. Castejon, J. P. Renou, F. Mounier-Vehier, G. Potagas, Ch. Duyckaerts, A. Filla, R. Schneider, G. Ronen, K. Nagata, J. P. Vedel, A. Henneberg, G. van Melle, C. Baratti, H. Knott, M. C. Prevett, A. Bes, B. Metin, Jos V. Reempts, L. Martorell, Mefkure Eraksoy, H. O. Handwerker, D. S. Younger, O. Oktem, D. Frongillo, C. Soriano-Soriano, L. Niehaus, F. Zipp, A. Tartaro, S Newman, R. H. Browne, P. Davous, R. Sanchez, M. Muros, M. E. Kornhuber, A. Lavarone, M. Mohr, M. R. Garcia, S. Russell, H. Kellar-Wood, M. R. Tola, B. Ostermeyer, Ch. Tzekov, K. Sartor, E. B. Ringelstein, P. P. Gazzaniga, Paul Krack, H. Fidaner, H. Rico, T. Dbaiss, F. Alameda, E. Torchiana, L. Rumbach, I. Charques, J. M. Bogaard, C. D. Frith, L. J. Rappelle, R. Brenner, A. Joutel, K. Fuxe, G. HÄcker, M. J. Blaser, J. Valls-SolÇ, G. Ulm, M. Alberdi, A. Bock, F. W. Bertelsmann, U. Wieshmann, J. Visa, J. R. Lupski, D. D'Amico, L. M. P. Ramos, A. A. Vanderbark, R. Horn, M. Warmuth, Dietmar Kühne, Mark S. Palmer, C. Ehrenheim, E. Canga, S. Viola, O. Scarpino, P. Naldi, R. Almeida, A. A. Raymond, J. Gamez, Stephan Arnold, A. DiGiovanni, J. Dalmau, C. C. Chari, H. F. Beer, J. C. Koetsier, J. Iriarte, E. Yunis, J. Casadevall, E. Le Guern, E. Stenager, S. R. Benbadis, J. M. Warter, F. Burklin, I. Theodorou, L. Johannesen, G. A. Graveland, X. Leclerc, I. Vecchio, L. Ozelius, G. Nicoletti, R. K. Gherardi, E. Esperet, M. L. Delodovici, F. Cattin, F. Paiau, Giorgio Sacilotto, C. A. J. Broere, D. Chavdarov, J. P. Willmer, C. H. Hawkes, Th. Naegele, E. Ellie, E. Dartigues, M. J. Guardiola, S. Hesse, Z. Levic, Marco Rovaris, P. Saugeir-Veber, B. A. Yaqub, H. F. Durwen, R. Larumbe, J. Ballabrina, M. Sendtner, J. Röther, M. Horstink, C. Kluglein, M.P. Montesi, H. Apaydin, J. Montoya, E. Waubant, Ch. Verellen-Dunoulin, A. Nicolai, J. Lopez-Delval, R. Lemon, G. Cantinho, E. Granieri, A. Zeviani, Wolfgang H. Oertel, U. Ficola, V. Di Piero, V. Fragola, K. Sabev, M. V. Guitera, I. Turki, F. Bolgert, P. Ingrand, J. M. Gobernado, L. M. E. Grimaldi, S. Baybas, B. Eymard, Y. Rolland, Y. Robitaille, Ta. Pampols, P. J. Koehler, A. Carroacedo, J. Vilchez, S. Di Vittorio, I. R. Rise, T. Nagy, M. Kuffner, E. Palazzini, A. Ott, J. Pruim, T. X. Arbizu, E. Manetti, C. Cervera, S. Felber, G. Gursoy, J. Scholz, G. A. Buscaino, M. S. Chen, A. Pascual, J. Hazan, J. U. Gajda, J. G. Cea, G. Bottini, G. Damalik, F. Le Doze, G. Bonaldi, J. M. Hew, C. Messina, A. M. Kennedy, J. M. Carney, N. M. F. Murray, M. Parent, M. Koepp, V. Dimova, D. De Leo, K. Jellinger, G. Salemi, S. Mientus, M. L. Hansen, F. Mazzucchelli, J. Vieth, M. Mauri, E. Bartels, L. Johannsen, C. Humphreys, J. Emile, D. N. Landon, E. Kansu, R. Sanchez-Pernaute, Rsj Frackowiak, M. Gonzalez Torres, L. Oller, C. Machedo, J. Kother, M. Billiard, H. Durak, T. Schindler, A. Frank, A. Uncini, A. Sbriccoli, C. Farinas, D. W. Paty, N. Fast, A. T. Zangaladze, A. Kerkhofs, J. M. Pino Garcia, I. De la Fuente, B. Marini, L. Gomez, I. Rubio, Alessandra Bardoni, C. Brodie, P. Acin, U. Sliwka, S. A. Hawkins, S. Tardieu, F. Vitullo, J. M. Pereira Monteino, R. Gagliardi, T. Jezewski, A. Cano, T. Lempert, F. Abad Alegria, G. Rotondo, D. Ince, C. Martinez Parra, Y. Huang, H. Luders, Y. Steinvil, F. G. A. Van Der Meche, R. Bianchi, A. Sanchez, T. Sevilla, J. M. Ketelslegers, A. Domzal-Stryga, M. Pandolfo, M. O. Josse, K. W. Neff, I. Blanco, G. W. Bruyn, O. W. Witte, J. L. Thibault, G. Andersen, J. Pariset, A. Marcone, R. J. M. Lane, A. Hofman, M. Verin, T. Matilla, P. Bedoucha, J. Roche, M. Lai, M. Collard, A. Ugarte, F. Gallecho, D. Silbersweig, C. Kennard, J. P. Azulay, T. W. Ho, P. L. I. Dellemijn, R. Girardello, F. Baas, B. Voss, F. Rozenberg, E. M. Brocker, V. Stanev, A. A. J. Soeterboek, A. Marra, A. Rey, E. Ertem, M. Sawradewicz-Rybak, J. De Keyser, P. Cavallari, F. Proust, Y. Chevalier, H. C. Hansen, D. Leys, C. A. Davie, K. Hoang-Xuan, C. Bairati, H. van Crevel, Thomas T. Warner, B. Bompais, A. Dobbeleir, T Campbell, C. Macko, C. J. M. Klijn, M. Dussallant, T. P. Berlit, W. Rozenbaum, M. J. van den Bent, W. A. Rocca, M. Muller, H. Hundemer, U. Zifko, M. Campera, F. Drislane, D. Ranoux, T. M. Kloss, Anil Kumar, I. Ruolt, C. Bargnani, B. Marescau, N. A. Losseff, S. Notermans, B. Kint, E. T. Burke, C. Aykut, J. Matias Guiu, P. Maquet, T. Drogendijk, M. Leone, K. von Ammon, M. Pepeliarska, C. Prados, L. DiGiamberardino, T. Logtenberg, G. Lenoir, I. Castaldo, Damhaut, M. Radionova, G. Sirabian, R. Navon, Giovanni Antonini, K. Al Moutaery, E. Chamas, R. Schönhuber, M. Giannini, B. Debilly, I. Labatut, H. Henon, J. A. Egido, M. Baudrimont, J. N. Lorenzo, J. E. C. Bromberg, R. Antonacci, J. J. Vilchez, T. Moulin, B. Rautenstrauss, Giovanni Meola, J. Noth, S Mammi, P. Laforet, F. Lopez, C. Gehring, S. Bort, G. Rancurel, D. Decamps, S. Kostadinova, Y. Shapira, B. Neundoerfer, D. Chavrot, M. Solimena, J. P. Salier, W. Deberdt, R. Hoff-Jörgensen, A. Messina, S. Meairs, G. Rosoklija, E. Nelis, I. Bertran, C. Ertekin, J. Lohmeyer, Mitermayer Galvao dos Reis, L. Calo, E. Maccagnano, A. P. Hays, J. Verlooy, M. G. Forno, T. Blanco, L. Bail, Gabriella Silvestri, J. Montero, F. Bertrand, R. T. Ghnassia, C. Besses, T. Sereghy, F. Shalit, G. Bogliun, S. Braghi, St. Baykouchev, C. Franke, A. Lasa, L. C. Archard, J. Kriebel, S. Shaunak, M. Nocito, Alexander Tsiskaridze, E. Manfredini, T. Seigal, David G. Gadian, M. Barlas, J. D. Degos, C. Seeber, J. Caemert, J. L. Mas, R. B. Pepinsky, M. G. 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Santoro, J. Roda, A. Bordoni, D. J. Taylor, S. Ertas, H. H. Emmen, J. Vichez, V. BesanÇon, R. E. Passingham, M. L. Malosio, A. Vérier, M. Bamberg, A. W. Hansen, E. Mostacero, G. Gaudriault, Marie Vidailhet, B. Birebent, K. Strijckmans, F. Giannini, T. Kammer, I. Araujo, J. Nowicki, E. Nikolov, A. Hutzelmann, R. Gherardi, J. Verroust, L. Austoni, A. Scheller, A. Vazquez, S. Matheron, H. Holthausen, J. M. Gerard, M. Bataillard, S. Dethy, V. H. Patterson, V. Ivanez, N. P. Hirsch, F. Ozer, M. Sutter, C. Jacomet, M. Mora, Bruno Colombo, A. Sarropoulos, T. H. Papapetropoulos, M. Schwarz, D. S. Dinner, N. Acarin, B. Iandolo, J. O. Riis, P. R. J. Barnes, F. Taroni, J. Kazenwadel, L. Torre, A. Lugaresi, I. L. Henriques, S. Pauli, S. Alfonso, Pedro Quesada, A. S. T. Planting, J. M. Castilla, Thomas Gasser, M. Van der Linden, A. Alfaro, E. Nobile-Orazio, G. Popova, W. Vaalburg, F. G. A. van der Mech, L. Williams, F. Medina, J. P. Vernant, J. Yaouanq, B. Storch-Hagenlocher, A. Potemkowski, R. Riva, M. H. Mahagne, M. Ozturk, Ve. Drory, N. Konic, C. Jungreis, A. Pou Serradell, J. L. Gauvrit, G. J. Chelune, S. Hermandez, T. Dingus, L. Hewer, Ch. Koch, M. N. Metz-Lutz, G. Parlato, M. Sinaki, Charles Pierrot-Deseilligny, H. C. Diener, J. Broeckx, J. Weill-Fulazza, M. L. Villar, M. Rizzo, O. Ganslandt, C. Duran, N. A. Fletcher, G. Di Giovacchino, Susan T. Iannaccone, C. Kolig, N. Fabre, H. A. Crockard, Rita Bella, M. Tazir, E. Papagiannuli, K. Overgaard, Emma Ciafaloni, I. Lorenzetti, F. Viader, P. A. H. Millac, I. Montiel, L. H. Visser, M. Palomar, P. L. Murgia, H. Pedersen, Rafael Blesa, S. Seddigh, W. O. Renier, I. Lemahieu, H. M. L. Jansen, L. Rosin, J. Galofre, K. Mattos, M. Pondal, G. M. Hadjigeorgiou, D. Francis, L. Cantin, D. Stegeman, M. Rango, A. B. M. F. Karim, S. Schraff, B. Castellotti, I. Iriarte, E. Laborde, T. J. Tjan, R. Mutani, D. Toni, B. Bergaasco, J. G. Young, C. Klotzsch, A. Zincone, X. Ducrocq, M. Uchuya, O. J. Kolar, A. Quattrone, T. Bauermann, Nereo Bresolin, J. Vallée, B. C. Jacobs, A. Campos, Werner Poewe, J. A. Villanueva, A. W. Kornhuber, A. Malafosse, E. Diez-Tejedor, G. Jungreia, M. J. A. Puchner, A. Komiyama, O. Saribas, V. Volpini, L. Geremia, S. Bressi, A. Nibbio, Timothy E. Bates, T. z. Tzonev, E. Ideman, G. A. Damlacik, G. Martino, G. Crepaldi, T. Martino, Kjell Någren, E. Idiman, D. Samuel, J. M. Perez Trullen, Y. van der Graaf, J. O. Thorell, M. J. M. Dupuis, E. Sieber, R. D'Alessandro, C. Cazzaniga, J. Faiss, A. Tanguy, A. Schick, I. Hoksergen, A. Cardozo, R. Shakarishvili, G. K. Wennlng, J. L. Marti-Vilalta, J. Weissenbach, I. L. Simone, Amalia C. Bruni, Darius J. Adams, C. Weiller, A. Pietrangeli, F. Croria, C. Vigo-Pelfrey, Patricia Limousin, A. Ducros, G. Conti, O. Lindvall, E. Richter, M. Zuffi, A. Nappo, T. Riise, J. Wijdenes, M. J. Fernandez, J. Rosell, P. Vermersh, S. Servidei, M. S. C. Verdugo, F. Gouttiere, W. Solbach, M. Malbezin, I. S. Watanabe, A. Tumac, W. I. McDonald, D. A. Butterfield, P. P. Costa, F. deRino, F. Bamonti, J. M. Cesar, C. H. Lahoz, I. Mosely, M. Starck, M. H. Lemaitre, K. M. Stephan, S. Tex, R. Bokonjic, I. Mollee, L. Pastena, M. Gutierrez, F. Boiler, M. C. Martinez-Para, M. Velicogna, O. Obuz, A. Grinspan, M. Guarino, L. M. Cartier, E. Ruiz, D. Gambi, S. Messina, M. Villa, Michael G. Hanna, J. Valk, Leone Pascual, M. Clanet, Z. Argov, B. Ryniewicz, E. Magni, B. Berlanga, K. S. Wong, C. Gellera, C. Prevost, F. Gonzalez-Huix, R. Petraroli, J. E. G. Benedikz, I. Kojder, C. Bommelaer, L. Perusse, M. R. Bangioanni, Guy M. McKhann, A. Molina, C. Fresquet, E. Sindern, Florence Pasquier, M. J. Rosas, M. Altieri, O. Simoncini, M. Koutroumanidis, C. A. F. Tulleken, M. Dary-Auriol, S. Oueslati, H. Kruyer, I. Nishisho, C. R. Horning, A. Vital, G. V. Czettritz, J. Ph. Neau, B. Mihout, A. Ameri, M. Francis, S. Quasthoff, D. Taussig, S. Blunt, P. Valentin, C. Y. Gao, O. Heinzlef, H. d'Allens, C. Coudero, M. Erfas, G. Borghero, P. J. Modrego Pardo, M. C. Patrosso, N. L. Gershfeld, P. A. J. M. Boon, O. Sabouraud, M. Lara, J. Svennevig, G. L. Lenzi, A. Barrio, H. Villaroya, JosÇ M. Manubens, O. Boespflug-Tanguy, M. Carreras, D. A. Costiga, J. P. Breux, S. Lynn, C. Oliveras Ley, A. G. Herbaut, J. Nos, C. Tornali, Y. A. Hekster, J. L. Chopard, J. M. Manubens, P. Chemouilli, A. Jovicic, F. Dworzak, S. Smirne, S. E. Soudain, B. Gallano, D. Lubach, G. Masullo, G. Izquierdo, A. Pascual Leone Pascual, A. Sessa, V. Freitas, O. Crambes, L. Ouss, G. W. Van Dijk, P. Marchettini, P. Confalonieri, M. Donaghy, A. Munnich, M. Corbo, and M. E. L. van der Burg
Subjects: Neurology, business.industry, Media studies, Library science, Medicine, Neurology (clinical), business
Published: 1994
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11. Abstracts

Author: J. M. Derlon, M. C. Petit-taboué, F. Dauphin, P. Courtheoux, F. Chapon, P. Creissard, F. Darcel, J. P. Houtteville, B. Kaschten, B. Sadzot, A. Stevenaert, Juri G. Tjuvajev, Homer A. Macapinlac, Farhad Daghighian, James Z. Ginos, Ronald D. Finn, M. S. Jiaju Zhang, Bradley Beattie, Martin Graham, Steven M. Larson, Ronald G. Blasberg, M. Levivier, S. Goldman, B. Pirotte, J. M. Brucher, D. Balériaux, A. Luxen, J. Hildebrand, J. Brotchi, K. G. Go, R. L. Kamman, E. L. Mooyaart, M. A. A. M. Heesters, P. E. Sijens, M. Oudksrk, P. van Dijk, P. C. Levendag, Ch. J. Vecht, R. J. Metz, D. N. Kennedy, B. R. Rosen, F. H. Hochberg, A. J. Fishman, P. A. Filipek, V. S. Caviness, M. W. Gross, F. X. Weinzierl, A. E. Trappe, W. E. Goebel, A. M. Frank, Georg Becker, Andreas Krone, Karsten Schmidt, Erich Hofmann, Ulrich Bogdahn, H. Bencsch, S. Fclber, G. Finkenstedt, C. Kremser, G. Sfockhammer, F. Aichner, U. Bogdahn, T. Fröhlich, G. Becker, A. Krone, R. Schlief, J. Schürmann, P. Jachimczak, E. Hofmann, W. Roggendorf, K. Roosen, C. M. Carapella, G. Carpinelli, R. Passalacqua, L. Raus, M. Giannini, R. Mastrostefano, F. Podo, A. Tofani, R. Maslrostefano, M. Mottoles, A. Ferraironi, M. G. Scelsa, P. Oppido, A. Riccio, C. L. Maini, L. Collombier, L. Taillandier, M. Dcbouverie, M. H. Laurens, P. Thouvenot, M. Weber, A. Bertrand, G. S. Cruickshank, J. Patterson, D. Hadley, Olivier De Witte, Jerzy Hildebrand, André Luxen, Serge Goldman, R. -I. Ernestus, K. Bockhorst, M. Eis, T. Els, M. Hoehn-Berlage, M. Gliese, R. Fründ, A. Geissler, C. Woertgen, M. Holzschuh, O. Hausmann, A. Merlo, E. Jerrnann, J. Uirich, R. Chiquet-Ehrismann, J. Müller, H. Mäcke, O. Gratzl, K. Herholz, M. Ghaemi, M. Würker, U. Pietrzyk, W. -D. Heiss, K. Kotitschke, M. Brandl, J. C. Tonn, A. Haase, S. Muigg, S. Felber, M. Woydt, Heinrich Lanfermann, Walter Heindel, Harald Kugel, Ralf -Ingo Erneslus, Gabricle Röhn, Klaus Lackner, F. S. Pardo, S. Kutke, A. G. Sorensen, L. L. Mechtler, S. Withiam-Lench, K. Shin, W. R. Klnkel, M. Patel, B. Truax, P. Kinkel, L. Mechtler, M. Ricci, P. Pantano, A. Maleci, S. Pierallini, D. Di Stefano, L. Bozzao, G. P. Cantore, Gabriele Röhn, R. Schröder, R. Ruda, C. Mocellini, R. Soffietti, M. Campana, R. Ropolo, A. Riva, P. G. de Filippi, D. Schiffer, D. Salgado, M. Rodrigues, L. Salgado, A. T. Fonseca, M. R. Vieira, J. M. Bravo Marques, H. Satoh, T. Uozumi, K. Kiya, K. Kurisu, K. Arita, M. Sumida, F. Ikawa, Tz. Tzuk-Shina, J. M. Gomori, R. Rubinstein, A. Lossos, T. Siegal, W. Vaalburg, A. M. J. Paans, A. T. M. Willemsen, A. van Waarde, J. Pruim, G. M. Visser, S. Valentini, Y. L. T. Ting, R. De Rose, G. Chidichimo, G. Corricro, Karin van Lcycn-Pilgram, Ralf -Ingo Erncslus, Norfried Klug, K. van Leyen-Pilgram, N. Klug, U. Neumann, Karl H. Plate, Georg Breier, Birgit Millaucr, Herbert A. Weich, Axel Ullrich, Werner Risau, N. Roosen, R. K. Chopra, T. Mikkelsen, S. D. Rosenblum, P. S. Yan, R. Knight, J. Windham, M. L. Rosenblum, A. Attanasio, P. Cavalla, A. Chio, M. T. Giordana, A. Migheli, V. Amberger, T. Hensel, M. E. Schwab, Luigi Cervoni, Paolo Celli, Roberto Tarantino, C. Huettner, U. Berweiler, I. Salmon, S. Rorive, K. Rombaut, J. Haot, R. Kiss, C. Maugard-Louboutin, J. Charrier, G. Fayet, C. Sagan, P. Cuillioere, G. Ricolleau, S. Martin, D. Menegalli-Bogeelli, Y. Lajat, F. Resche, Péter Molnàr, Helga Bárdos, Róza Ádány, J. P. Rogers, G. J. Pilkington, B. Pollo, G. Giaccone, A. Allegranza, O. Bugiani, J. Prim, J. Badia, E. Ribas, F. Coello, E. Shezen, O. Abramsky, M. Scerrati, R. Roselli, M. Iacoangeli, A. Pompucci, G. F. Rossi, Saleh M. Al. Deeb, Osama Koreich, Basim Yaqub, Khalaf R. Al. Moutaery, S. Marino, M. C. Vigliani, V. Deburghgraeve, D. Gedouin, M. Ben Hassel, Y. Guegan, B. Jeremic, D. Grujicic, V. Antunovic, M. Matovic, Y. Shibamoto, Merja Kallio, Helena Huhmar, Ch. Kudoh, A. Detta, K. Sugiura, E. R. Hitchcock, R. Di Russo, M. Cipriani§, E. M. Occhipinti, E. M. S. Conti, A. Clowegeser, M. Ortler, M. Seiwald, H. Kostron, B. Rajan, G. Ross, C. Lim, S. Ashlcy, D. Goode, D. Traish, M. Brada, G. A. C. vd Sanden, L. J. Schouten, J. W. W. Coebergh, P. P. A. Razenberg, A. Twijnstra, A. Snilders-Keilholz, J. H. C. Voormolen, J. Hermans, J. W. H. Leer, F. Baylac, M. Dcbouvcrie, R. Anxionnal, S. Bracard, J. M. Vignand, A. Duprcz, M. Winking, D. K. Böker, T. Simmet, David Rothbart, John Strugar, Jeroen Balledux, Gregory R. Criscuolo, Piotr Jachimczak, Armin Blesch, Birgit Heβdörfer, Ralf -Ingo Ernestus, Roland Schröder, Norfrid Klug, H. G. J. Krouwer, S. G. v. Duinen, A. Algra, J. Zentner, H. K. Wolf, B. Ostertun, A. Hufnagel, M. G. Campos, L. Solymosi, J. Schramm, E. S. Newlands, S. M. O'Reilly, M. Brampton, R. Sciolla, D. Seliak, R. Henriksson, A. T. Bergenheim, P. Björk, P. -O. Gunnarsson, Ml. Hariz, R. Grant, D. Collie, A. Gregor, K. P. Ebmeier, G. Jarvis, F. Lander, A. Cull, R. Sellar, C. Thomas, S. Elyan, F. Hines, S. Ashley, S. Stenning, J. J. Bernstein, W. J. Goldberg, U. Roelcke, K. Von Ammon, E. W. Radu, D. Kaech, K. L. Leenders, M. M. Fitzek, J. Efird Aronen, F. Hochberg, M. Gruber, E. Schmidt, B. Rosen, A. Flschman, P. Pardo, U. M. U. Afra, L. Sipos, F. Slouik, A. Boiardi, A. Salmaggi, A. Pozzi, L. Farinotti, L. Fariselli, A. Silvani, A. Brandes, E. Scelzi, A. Rigon, P. Zampieri, M. Pignataro, P. D'. Amanzo, P. Amista, A. Rotilio, M. V. Fiorentino, R. Thomas, L. Brazil, A. M. O'Connor, Maurizio Salvati, Fabrizio Puzzilli, Michele Raguso, R. Duckworth, R. Rumpling, M. Rottuci, G. Broggi, N. G. Plrint, E. Sabattini, V. Manetto, H. Gambacorta, S. Poggi, S. Pileri, R. Ferracini, D. V. Plev, N. J. Hopf, E. Knosp, J. Bohl, A. Perncczky, I. Catnby, O. Dewitte, J. L. Pasteels, I. Camby, F. Darro, A. Danguy, M. C. Kiu, G. M. Lai, T. S. Yang, K. T. Ng, J. S. Chen, C. N. Chang, W. M. Leung, Y. S. Ho, M. Deblec Rychter, A. Klimek, P. P. Liberski, A. Karpinaka, P. Krauseneck, V. Schöffel, B. Müller, F. W. Kreth, M. Faist, P. C. Warnke, C. B. Ostertag, K. M. B. v. Nielen, M. C. Visscr, C. Lebrun, M. Lonjon, T. Desjardin, J. F. Michiels, Sa. Lagrange J. L. Chanalet, J. L. Roche, M. Chatel, L. Mastronardi, F. Puzzilli, Farah J. Osman, P. Lunardi, M. Matsutani, Y. Ushio, K. Takakura, Johan Menten, Han Hamers, Jacques Ribot, René Dom, Hans Tcepen, N. Weidner, G. Naujocks, D. van Roost, O. D. Wiestler, A. Kuncz, C. Nieder, M. Setzel-Sesterhein, M. Niewald, I. Schnabel, K. S. O'Neill, N. D. Kitchen, P. R. Wilkins, H. T. Marsh, E. Pierce, R. Doshi, R. Deane, S. Previtali, A. Quattrini, R. Nemni, A. Ducati, L. Wrabetz, N. Canal, C. J. A. Punt, L. Stamatakis, B. Giroux, E. Rutten, Matthew R. Quigley, P. A. -C. Beth Sargent, Nicholas Flores, Sheryl Simon, Joseph C. Maroon, A. A. Rocca, C. Gervasoni, A. Castagna, P. Picozzi, E. Giugni, G. P. Tonnarelli, F. Mangili, G. Truci, M. Giovanelli, W. Sachsenheimer, T. Bimmler, H. Rhomberg W. Eiter, A. Obwegesser, H. Steilen, W. Henn, J. R. Moringlane, H. Kolles, W. Feiden, K. D. Zang, W. I. Sleudel, Andreas Steinbrecher, Martin Schabet, Clemens Heb, Michael Bamberg, Johannes Dichgans, G. Stragliotto, J. Y. Delattre, M. Poisson, L. Tosatto, P. D'Amanzo, N. Menicucci, S. Mingrino, W. I. Steudel, R. Feld, J. Ph. Maire, M. Caudry, J. Guerin, D. Celerier, N. Salem, H. Demeaux, J. F. Fahregat, M. E. Kusak, A. Bucno, J. Albisua, P. Jerez, J. L. Sarasa, R. Garefa, J. M. de Campos, A. Bueno, R. García-Delgado, R. García-Sola, A. A. Lantsov, T. I. Shustova, D. Lcnartz, R. Wellenreuther, A. von Deirnling, W. Köning, J. Menzel, S. Scarpa, A. Manna, M. G. Reale, P. A. Oppido, L. Frati, C. A. Valery, M. Ichen, J. P. Foncin, C. Soubrane, D. Khayat, J. Philippon, R. Vaz, C. Cruz, S. Weis, D. Protopapa, R. März, P. A. Winkler, H. J. Reulen, K. Bise, E. Beuls, J. Berg, W. Deinsberger, M. Samii, V. Darrouzet, J. Guérin, R. Trouette, N. Causse, J. P. Bébéar, F. Parker, J. N. Vallee, R. Carlier, M. Zerah, C. Lacroix-Jousselin, Joseph M. Piepmeier, John Kveton, Agnes Czibulka, G. S. Tigliev, M. P. Chernov, L. N. Maslova, José M. Valdueza, Werner Jänisch, Alexander Bock, Lutz Harms, E. M. Bessell, F. Graus, J. Punt, J. Firth, T. Hope, Osama Koriech, Saleh Al Deeb, Khalaf Al Moutaery, B. Yaqub, A. Franzini, R. Goldbrunner, M. Warmuth-Metz, W. Paulus, J. -Ch. Tonn, I. I. Strik, C. Markert, K. -W. Pflughaupt, B. P. O'Neill, R. P. Dinapoli, J. Voges, V. Sturm, U. Deuß, C. Traud, H. Treuer, R. Lehrke, D. G. Kim, R. P. Müller, Yu. S. Alexandrov, K. Moutaery, M. Aabed, O. Koreich, G. M. Ross, D. Ford, I. L. O. Schmeets, J. J. Jager, M. A. G. Pannebakker, J. M. A. de Jong, E. van Lindert, K. Kitz, S. Blond, F. Dubois, R. Assaker, M. C. Baranzelli, M. Sleiman, J. P. Pruvo, B. Coche-Dequeant, K. Sano, G. PetriČ-Grabnar, B. Jereb, N. Župančič, M. Koršič, N. G. Rainov, W. Burkert, Yukitaka Ushio, Masato Kochi, Youichi Itoyama, R. García, L. Ferrando, K. Hoang-Xuan, M. Sanson, P. Merel, O. Delattre, G. Thomas, D. Haritz, B. Obersen, F. Grochulla, D. Gabel, K. Haselsberger, H. Radner, G. Pendl, R. W. Laing, A. P. Warrington, P. J. C. M. Nowak, I. K. K. Kolkman-Deurloo, A. G. Visser, Hv. d. Berge, C. G. J. H. Niël, P. Bergström, M. Hariz, P. -O. Löfroth, T. Bergenheim, C. Cortet-rudelli, D. Dewailly, B. Coche-dequeant, B. Castelain, R. Dinapoli, E. Shaw, R. Coffey, J. Earle, R. Foote, P. Schomberg, D. Gorman, N. Girard, M. N. Courel, B. Delpech, G. M. Friehs, O. Schröttner, R. Pötter, R. hawliczek, P. Sperveslage, F. J. Prott, S. Wachter, K. Dieckmann, B. Bauer, R. Jund, F. Zimmermann, H. J. Feldmann, P. Kneschaurek, M. Molls, G. Lederman, J. Lowry, S. Wertheim, L. Voulsinas, M. Fine, I. Voutsinas, G. Qian, H. Rashid, P. Montemaggi, R. Trignani, C. West, W. Grand, C. Sibata, D. Guerrero, N. James, R. Bramer, H. Pahlke, N. Banik, M. Hövels, H. J. J. A. Bernsen, P. F. J. W. Rijken, B. P. J. Van der Sanden, N. E. M. Hagemeier, A. J. Van der Kogel, P. J. Koehler, H. Verbiest, J. Jager, A. McIlwrath, R. Brown, C. Mottolesb, A. Pierre'Kahn, M. Croux, J. Marchai, P. Delhemes, M. Tremoulet, B. Stilhart, J. Chazai, P. Caillaud, R. Ravon, J. Passacha, E. Bouffet, C. M. F. Dirven, J. J. A. Mooy, W. M. Molenaar, G. M. Lewandowicz, N. Grant, W. Harkness, R. Hayward, D. G. T. Thomas, J. L. Darling, N. Delepine, I. I. Subovici, B. Cornille, S. Markowska, JC. Desbois Alkallaf, J. KühI, D. Niethammer, H. J. Spaar, A. Gnekow, W. Havers, F. Berthold, N. Graf, F. Lampert, E. Maass, R. Mertens, V. Schöck, A. Aguzzi, A. Boukhny, S. Smirtukov, A. Prityko, B. Hoiodov, O. Geludkova, A. Nikanorov, P. Levin, B. D'haen, F. Van Calenbergh, P. Casaer, R. Dom, J. Menten, J. Goffin, C. Plets, A. Hertel, P. Hernaiz, C. Seipp, K. Siegler, R. P. Baum, F. D. Maul, D. Schwabe, G. Jacobi, B. Kornhuber, G. Hör, A. Merzak, H. K. Rooprai, P. Bullock, P. H. M. F. van Domburg, P. Wesseling, H. O. M. Thijssen, J. E. A. Wolff, J. Boos, K. H. Krähling, V. Gressner-Brocks, H. Jürgens, J. Schlegel, H. Scherthan, N. Arens, Gabi Stumm, Marika Kiessling, S. Koochekpour, G. Reifenberger, J. Reifenberger, L. Liu, C. D. James, W. Wechsler, V. P. Collins, Klaus Fabel-Schulte, Plotr Jachimczak, Birgitt Heßdörfer, Inge Baur, Karl -Hermann Schlingensiepen, Wolgang Brysch, A. Blesch, A. K. Bosserhoff, R. Apfel, F. Lottspeich, R. Büttner, R. Cece, I. Barajon, S. Tazzari, G. Cavaletti, L. Torri-Tarelli, G. Tredici, B. Hecht, C. Turc-Carel, R. Atllas, P. Gaudray, J. Gioanni, F. Hecht, J. A. Rey, M. J. Bello, M. Parent, P. Gosselin, J. L. Christiaens, J. R. Schaudies, M. Janka, U. Fischer, E. Meese, M. Remmelink, P. Cras, R. J. Bensadoun, M. Frenay, J. L. Formento, G. Milano, J. L. Lagrange, P. Grellier, J. -Y. Lee, H. -H. Riese, J. Cervós-Navarro, W. Reutter, B. Lippitz, C. Scheitinger, M. Scholz, J. Weis, J. M. Gilsbach, L. Füzesi, Y. J. Li, R. Hamelin, Erik Van de Kelft, Erna Dams, Jean -Jacques Martin, Patrick Willems, J. Erdmann, R. E. Wurm, S. Sardell, J. D. Graham, Jun -ichi Kuratsu, M. Aichholzer, K. Rössler, F. Alesch, A. Ertl, P. S. Sorensen, S. Helweg-Larsen, H. Mourldsen, H. H. Hansen, S. Y. El Sharoum, M. W. Berfelo, P. H. M. H. Theunissen, I. Fedorcsák, I. Nyáry, É. Osztie, Á. Horvath, G. Kontra, J. Burgoni-chuzel, P. Paquis, SW. Hansen, PS. Sørensen, M. Morche, F. J. Lagerwaard, W. M. H. Eijkenboom, P. I. M. Schmilz, S. Lentzsch, F. Weber, J. Franke, B. Dörken, G. Schettini, R. Qasho, D. Garabello, S. Sales, R. De Lucchi, E. Vasario, X. Muracciole, J. Régis, L. Manera, J. C. Peragut, P. Juin, R. Sedan, K. Walter, K. Schnabel, N. Niewald, U. Nestle, W. Berberich, P. Oschmann, R. D. Theißen, K. H. Reuner, M. Kaps, W. Dorndorf, K. K. Martin, J. Akinwunmi, A. Kennedy, A. Linke, N. Ognjenovic, A. I. Svadovsky, V. V. Peresedov, A. A. Bulakov, M. Y. Butyalko, I. G. Zhirnova, D. A. Labunsky, V. V. Gnazdizky, I. V. Gannushkina, M. J. B. Taphoorn, R. Potman, F. Barkhof, J. G. Weerts, A. B. M. F. Karim, J. J. Heimans, M. van de Pol, V. C. van Aalst, J. T. Wilmink, J. J. van der Sande, W. Boogerd, R. Kröger, A. Jäger, C. Wismeth, A. Dekant, W. Brysch, K. H. Schlingensiepen, B. Pirolte, V. Cool, C. Gérard, J. L. Dargent, T. Velu, U. Herrlinger, M. Schabet, P. Ohneseit, R. Buchholz, Jianhong Zhu, Regina Reszka, Friedrich Weber, Wolfgang Walther, L. I. Zhang, Mario Brock, J. P. Rock, H. Zeng, J. Feng, J. D. Fenstermacher, A. Gabizon, M. Beljanski, S. Crochet, B. Zackrisson, J. Elfverson, G. Butti, R. Baetta, L. Magrassi, M. R. De Renzis, M. R. Soma, C. Davegna, S. Pezzotta, R. Paoletti, R. Fumagalli, L. Infuso, A. A. Sankar, G. -L. Defer, P. Brugières, F. Gray, C. Chomienne, J. Poirier, L. Degos, J. D. Degos, Bruno M. Colombo, Stefano DiDonato, Gaetano Finocchiaro, K. M. Hebeda, H. J. C. M. Sterenborg, A. E. Saarnak, J. G. Wolbers, M. J. C. van Gemert, P. Kaaijk, D. Troost, S. Leenstra, P. K. Das, D. A. Bosch, B. W. Hochleitner, A. Obwegeser, W. Vooys, G. C. de Gast, J. J. M. Marx, T. Menovsky, J. F. Beek, V. Schirrmacher, A. Schmitz, A. M. Eis-Hübinger, p. h. Piepmeier, Patricia Pedersen, Charles Greer, Tommy Shih, Amr Elrifal, William Rothfus, L. Rohertson, R. Rampling, T. L. Whoteley, J. A. Piumb, D. J. Kerr, P. A. Falina, I. M. Crossan, K. L. Ho, M. M. Ruchoux, S. Vincent, F. Jonca, J. Plouet, M. Lecomte, D. Samid, A. Thibault, Z. Ram, E. H. Oldfield, C. E. Myers, E. Reed, Y. Shoshan, Tz. Siegal, G. Stockhammer, M. Rosenblum, F. Lieberman, A. J. A. Terzis, R. Bjerkvig, O. D. Laerum, H. Arnold, W. D. Figg, G. Flux, S. Chittenden, P. Doshi, D. Bignor, M. Zalutsky, Juri Tjuvajev, Michael Kaplitt, Revathi Desai, M. S. Bradley, B. S. Bettie, Bernd Gansbacher, Ronald Blasberg, H. K. Haugland, J. Saraste, K. Rooseni, A. J. P. E. Vincent, C. J. J. Avezaat, A. Bout, J. L. Noteboom, C. h. Vecht, D. Valerio, P. M. Hoogerbrugge, R. Reszka, J. Zhu, W. Walther, J. List, W. Schulz, I. I. J. C. M. Sterenborg, W. Kamphorst, H. A. M. van Alplien, P. Salander, R. Laing, B. Schmidt, G. Grau, T. Bohnstedt, A. Frydrych, K. Franz, R. Lorenz, F. Berti, A. Paccagnella, P. L. van Deventer, P. L. I. Dellemijn, M. J. van den Bent, P. J. Kansen, N. G. Petruccioli, E. Cavalletti, B. Kiburg, L. J. Müller, C. M. Moorer-van Delft, H. H. Boer, A. Pace, L. Bove, A. Pietrangeli, P. Innocenti, A. Aloe, M. Nardi, B. Jandolo, S. J. Kellie, S. S. N. De Graaf, H. Bloemhof, D. Roebuck, Pozza L. Dalla, D. D. R. Uges, I. Johnston, M. Besser, R. A. Chaseling, S. Koeppen, S. Gründemann, M. Nitschke, P. Vieregge, E. Reusche, P. Rob, D. Kömpf, T. J. Postma, J. B. Vermorken, R. P. Rampling, D. J. Dunlop, M. S. Steward, S. M. Campbell, S. Roy, P. H. E. Hilkens, J. Verweij, W. L. J. van Putten, J. W. B. Moll, M. E. L. van der Burg, A. S. T. Planting, E. Wondrusch, U. Zifko, M. Drlicek, U. Liszka, W. Grisold, B. Fazeny, Ch. Dittrich, Jan J. Verschuuren, Patricio I. Meneses, Myrna R. Rosenfeld, Michael G. Kaplitt, Jerome B. Posner, Josep Dalmau, P. A. E. Sillevis Smitt, G. Manley, J. B. Posner, G. Bogliun, L. Margorati, G. Bianchi, U. Liska, B. Casati, C. Kolig, H. Grisold, R. Reñe, M. Uchuya, F. Valldeoriola, C. Benedetti de Cosentiro, D. Ortale, R. Martinez, J. Lambre, S. Cagnolati, C. Vinai, M. G. Forno, R. Luksch, P. Confalonieri, J. Scholz, G. Pfeiffer, J. Netzer, Ch. Hansen, Ch. Eggers, Ch. Hagel, K. Kunze, Marc K. Rosenblum, and Frank S. Lieberman
Subjects: Cancer Research, Neurology, Oncology, Neurology (clinical)
Published: 1994
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12. [Considerations on a room for leave taking]

Author: M, Drlicek and P, Kraml
Subjects: Attitude to Death, Patients' Rooms, Right to Die, Humans, Interpersonal Relations
Abstract: Many patients die in hospitals and care centers. It is therefore necessary to create an environment for the dying person, as well as for relatives, which allows death to occur with dignity while also permitting a dignified farewell. A special room should be available for taking leave of the loved one and for the mourning of the relatives. This room should, as far as possible, be neutrally decorated while at the same time it should be appropriate for various cultures and religious requirements. In order to be able to take leave symbolically, it is necessary to place the departed in the light, for example from a window.
Published: 2005

13. Paraneoplastische zerebelläre Degeneration: Fallbeobachtung einer Patientin mit Mammakarzinom

Author: Manfred Kaufmann, W. Hacke, N. Niedermaier, J Huober, M. Drlicek, and G. Bastert
Subjects: Autoimmune disease, Pathology, medicine.medical_specialty, Cerebellum, business.industry, Obstetrics and Gynecology, medicine.disease, Paraneoplastic cerebellar degeneration, Breast cancer, medicine.anatomical_structure, Maternity and Midwifery, Carcinoma, Gait Ataxia, Medicine, Medical history, Cerebellar disorder, business
Abstract: Paraneoplastic Cerebellar Degeneration: Case Report on a Breast Cancer Patient: A description of medical history, diagnosis and therapy of a patient with breast cancer is presented. The patient showed primary symptoms of vertigo and truncal and gait ataxia. The cause of this cerebellar disorder was a paraneoplastic cerebellar degeneration (PCD) characterized by anti-Purkinje cell antibodies (anti-Yo) directed against specific epitops shared by Purkinje and tumour cells. The presence of these antibodies in some patients suggests an autoimmune mechanism, although their role in pathogenesis has not been established. Usually malignancies of the breast and the ovaries are associated with anti-Yo positive PCD. The intensive search for an underlying neoplasma led to the identification of a malignant tumour of the right breast. Tumour excision of subsequent immunosuppressive treatment resulted in a progression of PCD. Antibody titers remained nearly unchanged during the course of the disease.
Published: 1996
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14. [Collisiontumour composed of glioblastoma and meningioma-a case report]

Author: M, Drlicek, M, Aichholzer, G, Wurm, A, Bodenteich, and J, Fischer
Subjects: Male, Brain Neoplasms, Meningeal Neoplasms, Humans, Middle Aged, Glioblastoma, Meningioma, Tomography, X-Ray Computed
Abstract: A 51 year old caucasian male presented with headache, facial nerve paresis and continuing contraction of the visual field. CT scan revealed a singular intracerebral contrast enhancing lesion in the left frontal lobe. Intraoperatively the tumour was well demarcated. Frozen sections showed a high grade glioma. Paraffin sections revealed, in addition to the gliomatous component, some sharply demarcated nests of meningothelial cells. Immunohistochemistry with glial fibrillary acidic protein and epithelial membrane antigen confirmed a collision tumour consisting of a glioblastoma WHO-grade IV and a meningothelial meningioma WHO-grade I. The coincidence of these two different tumours at the same time and the same location leads us to the speculation, that the collision tumour might have been caused by malignant transformation of a reactive astrogliosis surrounding the meningioma.
Published: 2004

15. Atypical paraneoplastic syndrome associated with anti-Yo antibodies

Author: J, Finsterer, A, Bodenteich, and M, Drlicek
Subjects: Ovarian Neoplasms, Paclitaxel, Electromyography, Immunoblotting, Docetaxel, Middle Aged, Paraneoplastic Cerebellar Degeneration, Antibodies, Carboplatin, Electrophysiology, Purkinje Cells, Muscular Diseases, Muscle Spasticity, Evoked Potentials, Visual, Humans, Paraneoplastic Polyneuropathy, Female, Taxoids
Abstract: Polyneuropathy, myopathy and spasticity have not been described as a manifestation of a neurologic paraneoplastic syndrome (NPS) associated with anti-Yo antibodies (anti-Yo).The patient is a 60-year-old woman with a history of ovarectomy, salpingectomy, hysterectomy and omentectomy because of ovarian cancer with peritoneal carcinosis. From May to September 1999, she received chemotherapy with carboplatin and docetaxel. In June 1999, weaknesses of the lower limbs began to appear. Neurologic investigation revealed bilateral ptosis with right-sided predominance, exaggerated deep tendon reflexes, discrete distal weakness, wasting of the upper limbs and diffuse weakness of the lower limbs. She had slight CK elevation, elevated lactate dehydrogenase and aldolase levels. Testing for anti-neuronal antibodies revealed high serum titers of antibodies against the cytoplasm of Purkinje cells, confirmed as anti-Yo by immunoblot with recombinant proteins. CSF investigations showed 12/3 cells and positive oligoclonal bands. MRI of the brain showed bilateral, old ischemic basal ganglia lesions exclusively. Visually evoked potentials gave prolonged P100 latencies bilaterally. Nerve conduction studies and electromyography revealed motor polyneuropathy of the lower limbs. Muscle biopsy from the right anterior tibial muscle showed non-specific myopathic features.Polyneuropathy, myopathy and tetraspasticity may be the exclusive manifestations of an atypical NPS associated with anti-Yo. Anti-Yo may persist for years without relapse of the primary tumor.
Published: 2003

16. Oligoclonal T-cells in blood and target tissues of patients with anti-Hu syndrome

Author: François-Jérôme Authier, B. Benyahia, Romain K. Gherardi, Jean-Pierre Farcet, Marie-Hélène Delfau-Larue, Jean-Christophe Antoine, A. Créange, A. Plonquet, Wolfgang Grisold, M. Drlicek, Hélène Rouard, C. Khouatra, J.Y. Delattre, Jérôme Honnorat, and Patrick A. Dreyfus
Subjects: Adult, Male, Pathology, medicine.medical_specialty, T-Lymphocytes, Immunology, Clone (cell biology), Nerve Tissue Proteins, Biology, Gene Rearrangement, T-Lymphocyte, Peripheral blood mononuclear cell, Neuritis, Ganglia, Spinal, medicine, Immunology and Allergy, Cytotoxic T cell, Humans, Paraneoplastic Polyneuropathy, Aged, RNA-Binding Proteins, Gene rearrangement, Middle Aged, Sensory neuron, Clone Cells, medicine.anatomical_structure, Neurology, ELAV Proteins, Monoclonal, Female, Neurology (clinical), Lymph, Lymph Nodes, CD8
Abstract: T-cell clones of unknown significance (TCUS), assessed by monoclonal or oligoclonal T-cell patterns in PCR-DGGE, were detected in blood of 7/9 patients with anti-Hu syndrome. Clonal patterns were also detected in 2/2 neoplastic lymph nodes, and in 2/2 inflamed dorsal root ganglia from three patients. Only some T-cell clones found in target tissues were also detected in blood or non-target tissues, and likely corresponded to TCUS. In one patient, an identical T-cell clone was found in both neoplastic lymph node tissue and dorsal root ganglia, but not in blood. Dorsal root-infiltrating lymphocytes were cytotoxic CD8(+) TIA-1(+) T-cells. They were often found in close contact to sensory neurons, most of which expressed MHC-1. Taken together, these data support a direct effector role of cytotoxic CD8(+) T-cells, the same clones being likely operative in sensory neuron damage and immune-mediated tumor growth control.
Published: 2002

17. [Osteoid osteoma of the cervical spine. A case report]

Author: K, Holl, G, Wurm, K, Nussbaumer, M, Drlicek, and J, Wurm
Subjects: Male, Postoperative Complications, Spinal Neoplasms, Adolescent, Osteoma, Osteoid, Cervical Vertebrae, Humans, Tomography, X-Ray Computed, Magnetic Resonance Imaging
Published: 2001

18. [Frontal lobe dementia. Clinical-pathologic case reports]

Author: C, Zachhuber, F, Leblhuber, C, Bancher, K, Jellinger, and M, Drlicek
Subjects: Aged, 80 and over, Male, Brain Diseases, Humans, Dementia, Female, Neurodegenerative Diseases, Syndrome, Middle Aged, Parkinson Disease, Secondary, Aged, Frontal Lobe
Abstract: Frontal lobe dementia (FLD) is characterised clinically by personality changes and a progressive speech disorder finally leading to mutism. In the course of the disease also other neurological syndromes may occur such as parkinsonism, a partial Klüver-Bucy-syndrome or a degeneration of motoneurons (FLD + MND). The latter leads to death within about three years. The clinical diagnosis of FLD is supported by functional (SPECT) and morphological (CT, MRI) investigations. From 1988 to 1997, 9 cases of FLD (6 female, 3 male) were clinically diagnosed at our department of Gerontology, LNK Linz. In two of these cases the clinical diagnosis was confirmed histopathologically. Characteristically, all except one patients showed a presenile beginning of the disease. The clinical course was slowly progressive with a mean duration of about 10 years. Special attention was given to additional signs and symptoms of motor neuron disease, parkinsonism and hyperorality. Six patients suffered from FLD + MND; parkinsonism (rigid-akinetic type) and a partial Klüver-Bucy-syndrome were diagnosed in 5 cases each. In histopathological investigations the incidence of FLD seems to increase. This type of dementia should be considered as an important diagnosis differential of presenile dementia-syndromes.
Published: 1999

19. [Hyperthyroidism caused by TSH producing hypophyseal adenoma]

Author: R, Pichler, M, Hatzl, H, Huber, W, Maschek, M, Myslivecek, H, Mustafa, and M, Drlicek
Subjects: Adenoma, Diagnosis, Differential, Male, Thyroid Hormones, Pituitary Gland, Humans, Thyrotropin, Pituitary Neoplasms, Middle Aged, Hyperthyroidism, Paraneoplastic Endocrine Syndromes, Hypophysectomy
Abstract: Thyrotropin (TSH-)producing adenomas of the anterior pituitary gland are the least frequently encountered ones and constitute a very rare cause of hyperthyroidism. The case is presented of a 58 year old male patient with a well-known history of hyperthyroidism over a period of at least 9 years growing goiter. Despite different forms of medical treatment he presented a constant clinical pattern consisting of restlessness and paroxysmal tachycardial atrial fibrillation. Laboratory findings revealed elevated levels of circulating thyroid hormones despite inadequately high levels of TSH. MRI scan revealed an adenoma of the pituitary measuring 9 mm in diameter. After microsurgery, consisting of transphenoidal resection of the tumor, the patient recorded no clinical symptoms. Histological examination revealed positive immunohistochemical staining, with antibodies to TSH, but a negative reaction against the GH, PRL, FSH, LH and ACTH hormone antibodies. Moreover, the levels of circulating hormones (GH, PRL, FSH, LH and ACTH) were normal. TSH-alpha subunits were not elevated. Before the correct diagnosis was reached, this patient was treated for nine years with antithyroid drugs. Five months after the operation the patient showed normal values of circulating thyroid hormones and TSH and thus no thyroid-specific medication was necessary.
Published: 1997

20. Antibodies of the anti-Yo and anti-Ri type in the absence of paraneoplastic neurological syndromes: a long-term survey of ovarian cancer patients

Author: C. Kolig, Wolfgang Grisold, G. Bianchi, Guido Cavaletti, M. Drlicek, L. Marzorati, U. Liszka-Setinek, Graziella Bogliun, E. Wondrusch, B. Casati, Drlicek, M, Bianchi, G, Bogliun, G, Casati, B, Grisold, W, Kolig, C, Liszka Setinek, U, Marzorati, L, Wondrusch, E, and Cavaletti, G
Subjects: medicine.medical_specialty, Pathology, Neurology, Paraneoplastic Syndromes, DNA-Binding Protein, Ovary, Nerve Tissue Proteins, Immunofluorescence, Autoantigens, Follow-Up Studie, Central nervous system disease, Neoplasm Protein, Ribonuclease, Ribonucleases, Autoantigen, medicine, Neurological syndrome, Humans, Autoantibodies, Neoplasm Staging, Ovarian Neoplasms, biology, medicine.diagnostic_test, business.industry, Ovarian Neoplasm, Cystadenoma, Serous, Autoantibody, Peripheral Nervous System Diseases, medicine.disease, Autoantibodie, Cystadenoma, Serou, Neoplasm Proteins, DNA-Binding Proteins, medicine.anatomical_structure, Paraneoplastic Syndrome, Nerve Tissue Protein, biology.protein, Female, Neurology (clinical), Antibody, Peripheral Nervous System Disease, Ovarian cancer, business, Human, Follow-Up Studies
Abstract: In recent years several authors have described a close correlation between circulating antineuronal antibodies of different types and the occurrence of paraneoplastic neurological syndromes. Because this has not been widely accepted, we screened 300 serum samples from 181 ovarian cancer patients for the presence of circulating antineuronal antibodies by immunofluorescence. The findings were confirmed by immunoblotting. In 11 patients circulating antineuronal antibodies were detected. In 4 patients they were classified as anti-Yo and in 7 as anti-Ri, titres ranging from 1 : 400 to 1 : 204 800. All the patients underwent thorough neurological and neurophysiological investigations, with special regard to paraneoplastic syndrome. None of them had symptoms pointing to a paraneoplastic neurological syndrome, although patients were followed up to 2 years after the first examination. Thus the frequency of circulating antineuronal antibodies in ovarian cancer patients is higher than the frequency of paraneoplastic syndromes, and antibody positivity does not necessarily lead to the appearance of a neurological paraneoplastic syndrome.
Published: 1997

21. [Histopathologic studies in dementia--comparison with clinical findings]

Author: C, Zachhuber, F, Leblhuber, K, Jellinger, C, Bancher, and M, Drlicek
Subjects: Aged, 80 and over, Diagnostic Imaging, Male, Psychiatric Status Rating Scales, Brain, Electroencephalography, Diagnosis, Differential, Alzheimer Disease, Humans, Dementia, Female, Mental Status Schedule, Geriatric Assessment, Aged
Abstract: This paper compares the clinical diagnosis of dementia with the result of the neuropathological brain examination in 23 patients. Aim of this investigation was a verification of the clinical diagnosis. The diagnosis was based on the clinical findings, the Mini Mental State Examination, DSM-III-R classification of dementia, the NINCDS-ADRDA-criteria, results of laboratory tests, EEG, CCT and sonography. A total of 70% of the clinical diagnosis corresponded to the neuropathological results. In 25% of these cases which clinically showed the characteristics of Alzheimer's disease histopathological findings delineated dementia of non-Alzheimer-type. These results underline the importance of additional histopathological investigations in the diagnosis of dementia.
Published: 1997

22. Neuromuscular disorders in systemic malignancy and its treatment

Author: E, Wondrusch, U, Zifko, W, Grisold, M, Drlicek, and U, Setinek
Subjects: Neoplasms, Humans, Neuromuscular Diseases
Published: 1996

23. [Paraneoplastic cerebellar degeneration: case report of a patient with breast carcinoma]

Author: J, Huober, N, Niedermaier, M, Drlicek, M, Kaufmann, W, Hacke, and G, Bastert
Subjects: Cerebellar Ataxia, Paraneoplastic Syndromes, Breast Neoplasms, Middle Aged, Mastectomy, Segmental, Combined Modality Therapy, Autoimmune Diseases, Purkinje Cells, Nerve Degeneration, Biomarkers, Tumor, Humans, Female, Autoantibodies, Neoplasm Staging
Abstract: Case Report on a Breast Cancer Patient: A description of medical history, diagnosis and therapy of a patient with breast cancer is presented. The patient showed primary symptoms of vertigo and truncal and gait ataxia. The cause of this cerebellar disorder was a paraneoplastic cerebellar degeneration (PCD) characterized by anti-Purkinje cell antibodies (anti-Yo) directed against specific epitops shared by Purkinje and tumour cells. The presence of these antibodies in some patients suggests an autoimmune mechanism, although their role in pathogenesis has not been established. Usually malignancies of the breast and the ovaries are associated with anti-Yo positive PCD. The intensive search for the underlying neoplasma led to the identification of a malignant tumour of the right breast. Tumour excision of subsequent immunosuppressive treatment resulted in a progression of PCD. Antibody titers remained nearly unchanged during the course of the disease.
Published: 1996

24. T-cell-mediated ganglionitis associated with acute sensory neuronopathy

Author: H. Bernheimer, Wolfgang Kristoferitsch, Andrea Neisser, Franz Beer, J. A. Hainfellner, M. Drlicek, Herbert Budka, and Hans Lassmann
Subjects: Male, Pathology, medicine.medical_specialty, Ataxia, T cell, Biopsy, Autonomic ganglion, CD8-Positive T-Lymphocytes, Polymyositis, Ganglia, Sensory, Neuritis, Sural Nerve, medicine, Cytotoxic T cell, Humans, Ganglia, Autonomic, Aged, business.industry, Sensory loss, medicine.disease, Ganglion, medicine.anatomical_structure, Neurology, Immunology, Acute Disease, Sensation Disorders, Neurology (clinical), medicine.symptom, business, CD8, T-Lymphocytes, Cytotoxic
Abstract: A 67-year-old man presented with acute painful sensory loss, areflexia, ataxia, urinary retention, and severe constipation and became unable to walk within 2 weeks. He died suddenly 5 weeks after the onset of symptoms. Autopsy revealed widespread inflammation of sensory and autonomic ganglia with immunocytochemical evidence of a CD8 + T cell-mediated cytotoxic attack against ganglion neurons. This observation suggests a novel pathogenetic mechanism of immune-mediated human ganglion cell damage comparable to mechanisms operating in polymyositis.
Published: 1996

25. [Crohn disease in an AIDS patient]

Author: C, Armbruster and M, Drlicek
Subjects: Adult, Male, Acquired Immunodeficiency Syndrome, Ileocecal Valve, Crohn Disease, Humans, Intestinal Obstruction
Abstract: We report on a 32-year-old homosexual AIDS patient with Crohn's disease of the ileocecal region. Radiographically the bowel of this region showed thickening of the wall and moderate narrowing of the lumen. Sonography showed an enlargement of the mesenterial lymph nodes. Due to mechanic ileus, ileocecal resection was performed. Histology of the resected bowel segment revealed extensive inflammatory changes throughout the wall and deep ulcerations, corresponding to changes in Crohn's disease. An underlying infection was histologically excluded. The immunologic aspects of Crohn's disease and of AIDS, and the differential diagnoses of Crohn's disease in AIDS patients, are discussed.
Published: 1995

26. [Paraneoplastic neurologic syndromes. Classification and diagnosis]

Author: W, Grisold, M, Drlicek, B, Casati, U, Setinek, and E, Wondrusch
Subjects: Neurologic Examination, Neurons, Paraneoplastic Syndromes, Humans, Nervous System Diseases, Autoantibodies, Autoimmune Diseases
Abstract: Paraneoplastic neurologic syndromes may be the presenting symptoms of cancer or appear during the course of the disease. Current knowledge of paraneoplastic syndromes is discussed on the basis of Henson and Urich's classification. The recognition of antineuronal antibodies in some neurologic paraneoplastic syndromes has had an impact on diagnostic possibilities. Additionally, there are new considerations relating to pathogenesis and therapy. Although the value and diagnostic yield of antineuronal antibodies are the subject of major discussion, they are already of significant diagnostic value in the diagnosis of paraneoplastic neurologic syndromes.
Published: 1995

27. Expert consultation by use of telepathology--the Heidelberg experiences

Author: K, Kayser, P, Fritz, M, Drlicek, and W, Rahn
Subjects: Computer Communication Networks, Intraoperative Period, Lung Neoplasms, Pathology, Clinical, Clinical Laboratory Techniques, Germany, Remote Consultation, Telecommunications, Frozen Sections, Humans, Immunohistochemistry, In Situ Hybridization
Abstract: The benefits and constraint using visual telecommunication in pathology (telepathology) are described based upon the experiences of the authors for more than 4 years. The experiences include first trials in visual telecommunication to analyze image quality, transfer rates, handling of commercially available equipment, and need for routinely diagnostic work followed by routinely expert consultations in frozen sections. A quality control study on diagnostic reliability of bronchial carcinomas was performed later, and the diagnosticly different cases were reclassified by a panel of pathologists using visual telecommunication. The latest experiences are based upon routinely expert consultations in morphologically difficult cases by ISDN-based telecommunication. As a result, image quality and transfer rates are sufficient to permit efficient expert contribution to diagnostically difficult cases in 30-50% of transmitted cases in both common telephone lines and ISDN connections. No influence of various staining procedures, immunohistology, or in situ hybridization on image quality or transfer rates were observed. The area of transmitted images is still too small, and the reliability of ISDN lines is still not sufficient for remote control service in Germany. The handling of commercially available equipment needs to be improved; however, as a general result, telepathology will probably improve the diagnostic quality and access in histopathology within the coming years.
Published: 1995

28. Pneumoconiosis and systemic sclerosis following 10 years of exposure to polyvinyl chloride dust

Author: G Menzinger, M J Studnicka, M G Neumann, H Maruna, and M Drlicek
Subjects: Pulmonary and Respiratory Medicine, Male, Pathology, medicine.medical_specialty, Systemic disease, Poison control, Scleroderma, Scleroderma, Localized, Occupational Exposure, Biopsy, medicine, Humans, Thickened skin, Polyvinyl Chloride, Lung, medicine.diagnostic_test, business.industry, Pneumoconiosis, Granuloma, Foreign-Body, Dust, Middle Aged, medicine.disease, medicine.anatomical_structure, Chemical Industry, Foreign body, business, Research Article
Abstract: The case history is presented of a 58 year old man who was exposed to thermoplastic dusts, mainly polyvinyl chloride (PVC), for 10 years. Radiography and high resolution computed tomographic scans of the lungs suggested both pneumoconiotic and scleroderma-like lesions. Transbronchial biopsy revealed foreign body granulomas with macrophages laden with birefringent inclusions which ultrastructurally resembled PVC dust. Biopsy samples of thickened skin showed histological evidence of extensive fibrosis. During follow up Raynaud's phenomenon and oesophageal involvement developed. The antinuclear antibody titre was 1:640, and the Sc1-70 subset was positive. It is concluded that exposure to PVC dust may cause pneumoconiosis and secondary systemic sclerosis.
Published: 1995

29. [Idiopathic CD4+ T-lymphocytopenia in 2 patients without indications for HIV infection]

Author: W, Pohl, C, Armbruster, K, Bernhardt, M, Drlicek, and N, Vetter
Subjects: Adult, Diagnosis, Differential, Male, HIV Seronegativity, Humans, Immunoglobulins, Female, Homosexuality, Male, Opportunistic Infections, T-Lymphocytopenia, Idiopathic CD4-Positive, CD4 Lymphocyte Count
Abstract: We report on two patients with idiopathic CD4+ T cell depletion. A 26 year-old woman presented to us with acute respiratory failure requiring mechanical ventilation. Despite combined antibiotic therapy parenterally the opacities increased in the chest X-ray. An open lung biopsy was performed and led to the histological diagnosis of bronchiolitis obliterans organizing pneumonia (BOOP). Respiratory function was improved impressively by high dose parenteral cortisone administration. This patient showed a general lymphocytopenia with severe CD4+ T cell depletion (60(37%)/mm3 blood). The CT4+ T cell concentration increased during a follow up period of 14 months, but did not reach normal values. The second patient was a 33 year-old homosexual. He was admitted with a mucocutaneous fungal infection which was successfully treated by antifungal drugs. This patient demonstrated a transient CD4+ T cell depletion (350(32%)/mm3 blood). In both patients HIV type 1 and 2 infections were excluded by antibody- and p 24-antigen testing, polymerase chain reaction and virus culture. CONCLUSION. Idiopathic CD4+ T lymphocytopenia differs from HIV infection in immunological profile, in the tendency to reversal of the CD4+ T cell depletion over time and in its better prognosis. It is unclear if this is a new syndrome and whether a transmissible agent, or possibly a genetically-determined reaction to noxious agents is responsible.
Published: 1995

30. Hirnnervenausfälle bei Tumorpatienten

Author: E. Machacek, W. Grisold, M. Drlicek, P. Hitzenberger, W. Kumpan, A. Urmann, U. Zifko, and E. Wondrusch
Abstract: Hirnnervenausfalle bei Patienten mit malignen Tumoren konnen neoplastische oder nicht neoplastische Ursachen haben. Zentrale Hirnnervenparesen sind vorwiegend durch Metastasen oder lokale Tumoreinwirkung verursacht, seltener sind auch nicht tumorbedingte Begleiterkrankungen anzufuhren. Periphere Hirnnervenlasionen konnen durch Schadelbasismetastasen, Meningealkarzinosen, lokale Weichteilinfiltration, iatrogene Ursachen (chirurgische Eingriffe, Fibrosen nach Bestrahlung, Chemotherapie) oder sehr selten paraneoplastisch bedingt sein.
Published: 1995
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31. Paraneoplastic sensory neuropathy

Author: U. Liszka, P. Hitzenberger, T. Paternostro, M. Drlicek, W. Grisold, and K. Jellinger
Subjects: Paraneoplastic sensory neuropathy, medicine.medical_specialty, Guillain-Barre syndrome, business.industry, Paraneoplastic neuropathy, Context (language use), Sensory system, medicine.disease, Dermatology, Sensory neuropathy, Medicine, Critical illness polyneuropathy, business, Lambert-Eaton myasthenic syndrome
Abstract: Sensory neuropathy and its rare variant sensory neuronopathy (or pure sensory ataxic) neuronopathy are frequently considered in the context of paraneoplastic neurologic disorders. From the figures in literature concerning the incidence and further diagnostic value of paraneoplastic neuropathy it is obvious that the pure sensory type is a rare association.
Published: 1995
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32. Pathologie des Zentralnervensystems bei AIDS. Ein Überblick über 217 Autopsien

Author: W. Grisold, K. Jellinger, F. Lintner, M. Drlicek, A. Steuer, U. Liszka, and E. Wondrusch
Abstract: Bei der HIV Infektion wird ein breites Spektrum an HIV induzierten Veranderungen, opportunistischen Infektionen und Tumoren des Zentralnervensystems (ZNS) beschrieben. Die Haufigkeitsverteilung der Lasionen wird durch geographische und demographische Faktoren mitbestimmt. In der folgenden Arbeit geben wir fur den Zeitraum 1984 – 1993 einen Uberblick uber neuropathologische Veranderungen in 217 Gehirnen von an AIDS Verstorbenen in Wien.
Published: 1995
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33. [Herpes simplex virus type II infection as an exophytic endobronchial tumor]

Author: C, Armbruster and M, Drlicek
Subjects: Male, Herpes Genitalis, Lung Neoplasms, AIDS-Related Opportunistic Infections, Herpesvirus 2, Human, Bronchi, Middle Aged, Neoplasms, Multiple Primary, Tumor Virus Infections, Cerebellum, Humans, Tracheitis, Bronchitis, Cerebellar Neoplasms, Lung, Lymphoma, AIDS-Related
Abstract: We report the case of a 52 year-old homosexual AIDS patients suffering from Herpes simplex virus type II infection of the esophagus and the bronchial system. The chest radiograph revealed a homogeneous, well-defined consolidation of the right upper lobe. Gastroscopy showed an ulcer of the esophagus and gastritis of the antrum. Bronchoscopically, marked necrotizing tracheobronchitis and an exophytic tumour causing complete blockage of the apical segment of the right upper lobe were demonstrated. Histological examination of the biopsy specimens of the esophagus and of the bronchus revealed Herpes simplex virus type II infection of both organs. The patient was treated by acyclovir for 2 weeks. 6 weeks after the diagnosis of acute Herpes simplex virus type II infection had been established, the patient died as a result of a highly malignant non-Hodgkin's lymphoma of the cerebellum. Autopsy showed no remaining endobronchial tumour. Histological examination of the bronchus showed no evidence of viral infection or non-Hodgkin's lymphoma. An endobronchial tumour caused by Herpes simplex virus type II infection has not been described up to now.
Published: 1995

34. Tumoren des Respirationstrakts einschließlich Ohr

Author: G. Mikuz, H. H. Popper, M. Drlicek, H. Höfler, and St. Wuketich
Subjects: business.industry, Medicine, business
Published: 1994
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35. Aids of telepathology in intra-operative histomorphological tumor diagnosis and classification

Author: K, Kayser, M, Drlicek, and W, Rahn
Subjects: Intraoperative Care, Lung Neoplasms, Pathology, Clinical, Humans, Referral and Consultation, Telemedicine
Abstract: Visual telecommunication (telepathology) was applied for expert consultation in intra-operative frozen sections and tumor classification of paraffin-embedded, poorly differentiated bronchial carcinoma. The Institute of Pathology, Hospital Baumgartnerhöhe, Vienna and the Department of Pathology, Thoraxklinik, Heidelberg transmitted histological images by use of commercially available computerized modems (VP 2000) and conventional telephone lines. The expert consultation of the frozen sections included the clinical history, macroscopic findings and problems of final judgement of the images. Additional useful information could be obtained in about 35% of cases, and comprised expansion of differential diagnosis, certainty of final diagnosis, and side findings, such as concurrent inflammation, sarcoid-like lesions, etc. The time required for intra-operative diagnosis was 6-10 min. Cases of the Austrian-German quality control study on lung cancer with divergent tumor classification were discussed by use of telepathology. A final congruent tumor diagnosis could be obtained in all divergent cases. The data indicate that telepathology can be successfully used for expert consultation of intra-operative frozen sections and panel discussions of difficult bronchial carcinoma cases.
Published: 1993

36. Nuclear and Fascicular Oculomotor Nerve Lesions in Brain-Stem Infarcts: A Clinicomorphological Study

Author: W. Grisold, D. Volc, K. Jellinger, and M. Drlicek
Subjects: Midbrain, Inferior rectus muscle, Inferior oblique muscle, genetic structures, Oculomotor nerve, Medial rectus muscle, sense organs, Anatomy, Biology, Levator Palpebrae Superioris, Oculomotor nucleus, Superior rectus muscle
Abstract: Lesions of the oculomotor nerve nucleus are rare. Anatomically, the nuclear complex of the third nerve extends rostrocaudally, ventral to the aqueduct in the long axis of the midbrain. Dorsal and rostral to the main oculomotor nuclei is the unpaired autonomic Westphal-Edinger nucleus, and at the caudal level is the caudal central nucleus of the levator palpebrae superioris. The main part of the oculomotor complex consists of two paired columns that are topographically divided into dorsolateral, intermediate, and ventrolateral nuclei. The most medial subnuclei innervate the superior rectus muscle. Each medial subnucleus has fibers extending to the opposite eye, but decussation takes place within the nuclear complex. The decussating fibers for the superior rectus muscle traverse the contralateral subnucleus. However, the lateral oculomotor subnuclei have axons that extend to the ipsilateral eye fibers (dorsal subnucleus: inferior rectus muscle; intermediate subnucleus: inferior oblique muscle) Neurons supporting the medial rectus muscle are distributed in three different subnuclei [9].
Published: 1993
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37. [Pathology of the central nervous system in AIDS. An overview of 184 patients]

Author: M, Drlicek, U, Liszka, E, Wondrusch, K, Jellinger, F, Lintner, W, Grisold, and B, Casati
Subjects: AIDS Dementia Complex, Lymphoma, B-Cell, AIDS-Related Opportunistic Infections, Brain Neoplasms, Austria, HIV Seropositivity, Brain, Humans
Abstract: Based on a consecutive autopsy series of 184 patients with AIDS, a critical review of the pathology of the central nervous system (CNS) is given. The lesions can be divided into three groups: 1. opportunistic/non-opportunistic infections, 2. changes due to the human immunodeficiency virus (HIV), and 3. neoplasms. The frequency and morphology of CNS lesions in our cohort are compared with those in other series. Marked lesions of the CNS were found in 111 patients (60%), while mild/nonspecific changes were seen in 52 cases (28%). Toxoplasmosis (23%) was the most frequent CNS infection, followed by cytomegalovirus (17%), and papovirus (5%). HIV giant cell encephalitis, HIV leukoencephalopathy, vacuolar myelopathy and leukoencephalopathy were observed in 11%. Primary CNS lymphomas were present in 6%, while secondary involvement of the CNS in systemic lymphomas was seen in only two cases (1%). Lesions due to CNS infections in patients with AIDS often show atypical patterns, and frequently, there are multiple infections with simultaneous involvement of the CNS by lesions of different etiology. The present study confirms the frequent involvement of the CNS in AIDS, although there are differences in the incidence and pattern of lesions related to geographic and/or demographic factors.
Published: 1993

38. Visual telecommunication for expert consultation of intraoperative sections

Author: K, Kayser and M, Drlicek
Subjects: Intraoperative Period, Time Factors, Consultants, Neoplasms, Humans, Television, Telemedicine, Telephone
Abstract: Histopathological images of intraoperative sections were transferred by use of normal telephone line between the Department of Pathology, Thoraxklinik, Heidelberg, and the Institute of Pathology, Hospital Baumgartnerhöhe, Vienna. The images were digitized using a colour TV camera and stored in a specific image transmission system (VP2000). The transfer of one image lasted 1.4-2 min at average; normally two different areas of the section were transmitted. The expert discussion including the clinical history usually started a few minutes prior to the image transfer, and was finished 3 min after the transfer of the last image. A substantial assistance in the intraoperative classification of the disease was achieved in 37% of the 35 submitted cases. The images transfer was only useful for medium to high magnifications of the microscope, i.e., an objective x 25 or higher. The trail allows the following conclusions: a) Visual transfer of microscopic images is a useful technique for expert consultation of intraoperative sections, and can give additional information in 20-40% of the analyzed cases; b) it is useful only for medium or high microscopic magnifications and limited by the spatial resolution of the TV cameras.
Published: 1992

39. Dissociated unilateral convergence paralysis in a patient with thalamotectal haemorrhage

Author: Wolfgang Grisold, K Lindner, M Drlicek, and P. Hitzenberger
Subjects: Intracranial Arteriovenous Malformations, Male, medicine.medical_specialty, Superior Colliculi, genetic structures, Thalamus, Reflex, Pupillary, Thalamic Diseases, Lesion, Neural Pathways, medicine, Paralysis, Oculomotor Nerve Diseases, Humans, Dominance, Cerebral, Cerebral Hemorrhage, Neurologic Examination, Anisocoria, medicine.diagnostic_test, business.industry, Arteriovenous malformation, Magnetic resonance imaging, Convergence, Ocular, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Surgery, Psychiatry and Mental health, Thalamic Nuclei, Angiography, Neurology (clinical), medicine.symptom, business, Tomography, X-Ray Computed, Research Article
Abstract: A 47 year old male was admitted in a comatose state. CT scan showed a haemorrhage in the right pulvinar thalamus descending into the right part of the lamina quadrigemina. He presented with anisocoria, prompt bilateral pupillary light reaction, and unilateral convergence paralysis contralateral to the lesion in combination with upward gaze palsy. During an observation period of two months, the convergence reaction returned to normal. MRI showed a lacunar lesion ventral to superior right colliculus. Angiography revealed an arteriovenous malformation (right posterior cerebral artery--sinus rectus) as the possible cause of the haemorrhage.
Published: 1992

40. [Circulating anti-neural antibodies, an indication of a subtype of small cell lung cancer?]

Author: M, Drlicek, U, Liszka, W, Grisold, A, Mohn-Staudner, and F, Lintner
Subjects: Adult, Male, Neurons, Lung Neoplasms, Paraneoplastic Syndromes, Middle Aged, Survival Rate, Biomarkers, Tumor, Humans, Female, Carcinoma, Small Cell, Lung, Aged, Autoantibodies, Neoplasm Staging
Published: 1991

41. [Anticerebellar antibodies--anti-Hu and anti-Yo--in the diagnosis of paraneoplastic neurologic syndromes]

Author: W, Grisold, M, Drlicek, and U, Liszka
Subjects: DNA-Binding Proteins, Immunoenzyme Techniques, Bacterial Proteins, Paraneoplastic Syndromes, Fluorescent Antibody Technique, Humans, Nerve Tissue Proteins, Nervous System Diseases, Autoantigens, Autoantibodies, Autoimmune Diseases, Neoplasm Proteins
Abstract: The detection of antineuronal antibodies against cytoplasm and nuclei of Purkinje cells is considered to be an essential factor in the diagnosis of neurologic paraneoplastic syndromes. Published data rely on different immunological methods and relatively small numbers of patients. The clinical relevance of this phenomenon is not clear from the literature. A positive correlation between antibody detection and the appearance of neurologic paraneoplastic syndromes has been reported, but this finding has been questioned in critical reviews.
Published: 1991

42. [Clinical symptoms and diagnostic criteria in polyradiculitis--Landry Guillain Barré]

Author: W, Grisold, M, Drlicek, and U, Liszka
Subjects: Diagnosis, Differential, Autonomic Nervous System Diseases, Polyradiculoneuropathy, Sensation, Humans, Pain, Paralysis, Prognosis, Cranial Nerve Diseases
Abstract: Acute polyradiculitis ("acute inflammatory demyelinating polyradiculitis--AIDP" or the Landry-Guillain-Barré syndrome--GBS) is an acute inflammatory disease of the peripheral nervous system. Despite extremely severe courses and complications, the prognosis is favourable for the majority of patients. The typical clinical course is featured by non-characteristic sensory symptoms following an infection, with ensuing ascending motor signs and symptoms which, in 80% of the patients, reach a maximum within two weeks. The legs are usually involved before the arms. About 50% of the patients show involvement of cranial nerves. In the acute phase, respiratory insufficiency and autonomous dysfunctions may occur. For diagnosis, predominantly clinical criteria are used according to the criteria summarized by Asbury.
Published: 1991

43. Angiotropic lymphoma (malignant angioendotheliomatosis) presenting with rapidly progressive dementia

Author: U. Liszka, M. Drlicek, P. Hitzenberger, Wolfgang Grisold, and E. Machacek
Subjects: Male, Pathology, medicine.medical_specialty, Lymphoma, B-Cell, Autopsy, Disease, Creutzfeldt-Jakob Syndrome, Pathology and Forensic Medicine, Diagnosis, Differential, Cellular and Molecular Neuroscience, mental disorders, medicine, Cadaver, Dementia, Humans, B cell, Aged, Aged, 80 and over, business.industry, Brain Neoplasms, Large-cell lymphoma, medicine.disease, Immunohistochemistry, nervous system diseases, Viscera, Angiotropic Lymphoma, medicine.anatomical_structure, Hemangioendothelioma, Neurology (clinical), Lymphoma, Large B-Cell, Diffuse, medicine.symptom, business, Myoclonus
Abstract: An 87-year-old male presented with rapidly progressive dementia, disorder of consciousness and myoclonus, suggesting Creutzfeldt-Jakob disease, but with nonspecific EEG and negative CT findings. Autopsy revealed a malignant angiotropic lymphoma with accumulation of tumor cells within small vessels of the brain and visceral organs. Immunohistochemistry disclosed a large cell lymphoma of B cell type.
Published: 1991

44. High dose immunoglobulin therapy is effective in the Miller Fisher syndrome

Author: Wolfgang Grisold, M. Drlicek, G. Senautka, and Udo A. Zifko
Subjects: medicine.medical_specialty, Pediatrics, Neurology, business.industry, Immunology, medicine, Miller-Fisher syndrome, Neurology (clinical), business, Neuroradiology
Published: 1993
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45. Neurolymphomatosis

Author: W. Grisold, M. Drlicek, and K. Jellinger
Subjects: Neurology (clinical)
Published: 1993
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46. Sensorische Neuronopathie bei kleinzelligem Bronchuskarzinom

Author: W. Grisold, M. Drlicek, K. Jellinger, and W. Popp
Subjects: Pathology, medicine.medical_specialty, Lung, medicine.anatomical_structure, business.industry, medicine, Sensory system, Neurology (clinical), business, Small Cell Cancer
Published: 1989
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47. Reactivity of circulating antineuronal antibodies (CANA) on peripheral nervous system structures

Author: M. Drlicek, W. Popp, Wolfgang Grisold, U. Liszka, and Kurt A. Jellinger
Subjects: Pathology, medicine.medical_specialty, Lung Neoplasms, medicine.diagnostic_test, Paraneoplastic Syndromes, Schwann cell, Skeletal muscle, Biology, Immunofluorescence, Pathology and Forensic Medicine, Staining, Cellular and Molecular Neuroscience, medicine.anatomical_structure, Antigen, Peripheral nervous system, Immunology, medicine, biology.protein, Humans, Peripheral Nerves, Neurology (clinical), Neuron, Carcinoma, Small Cell, Antibody, Autoantibodies
Abstract: The appearance of circulating antineuronal antibodies (CANA) in patients with malignant tumors has been correlated with the occurrence of paraneoplastic neurological syndromes. However, the effect of CANA on the peripheral nervous system is poorly understood. The reactivity of sera from CANA-positive and -negative patients were investigated on cryostat sections of peripheral nerves and skeletal muscle, and on nerve tease-fiber preparations. Only CANA-positive sera showed staining of Schwann cell nuclei on cryostat sections, whereas nerve tease-fiber preparations and sections of skeletal muscle remained negative. Positive direct immunofluorescence of small cell lung cancer (SCLS) cells was confined to CANA-positive patients only. These findings suggest the existence of a common antigen between SCLC and Schwann cells.
Published: 1988
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48. Vergleich der Wirksamkeit von Ceftazidim und Cefazolin/Tobramycin bei Patienten mit entzündlichen Erkrankungen der tiefen Atemwege

Author: Ch. Armbruster, N. Vetter, M. Drlicek, and H. Feist
Subjects: Microbiology (medical), medicine.medical_specialty, Respiratory tract infections, Combination therapy, business.industry, Cefazolin, Ceftazidime, General Medicine, medicine.disease_cause, Gastroenterology, Infectious Diseases, medicine.anatomical_structure, Superinfection, Internal medicine, Anesthesia, medicine, Tobramycin, Sputum, medicine.symptom, business, medicine.drug, Respiratory tract
Abstract: We compared the efficacy of ceftazidime and cefazolin in combination with tobramycin in the treatment of lower respiratory tract infections. Bacterial pathogens were isolated from sputum or bronchial secretions from 92 patients. The clinical results were identical in both groups: All patients showed an improvement of the clinical symptoms or were cured. 88% of the patients in the ceftazidime-group and 76% of the patients in the cefazolin/tobramycin-group showed an eradication of the pathogens without superinfection. This difference was not statistically significant (p = 0.095). Monotherapy with ceftazidime was clinically and bacteriologically as effective as a combination therapy with cefazolin and tobramycin.
Published: 1987
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49. [The pathogen spectrum in respiratory tract infections with reference to different clinical diagnoses]

Author: M, Drlicek and G, Kapfhammer
Subjects: Bacteriological Techniques, Bacteria, Sputum, Humans, Bacterial Infections, Respiratory Tract Infections
Published: 1988

50. In vitro resistance of a 4-quinolone after two years of clinical use

Author: M, Drlicek, W, Grisold, C, Armbruster, and N, Vetter
Subjects: Enterobacteriaceae, Drug Resistance, Bacterial, Urinary Tract Infections, Enterococcus faecalis, Humans, Microbial Sensitivity Tests, Quinolones, Anti-Bacterial Agents
Published: 1989

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