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2. Anaphylactic Reactions With 3 Nonrelated Drugs (Gadoteridol, Paclitaxel, Bevacizumab) in a Patient With Severe Comorbidities

Author

M D Alonso-Díaz-de-Durana, T Alfaya Arias, Lucia Gonzalez-Bravo, M A Tejedor Alonso, I Álvarez-Twose, A Nieto Nieto, and J Laiseca García

Subjects
Oncology, medicine.medical_specialty, Paclitaxel, Bevacizumab, medicine.drug_class, medicine.medical_treatment, Immunology, Gadolinium, Monoclonal antibody, Drug Hypersensitivity, chemistry.chemical_compound, Heterocyclic Compounds, Internal medicine, Organometallic Compounds, medicine, Humans, Immunology and Allergy, Anaphylaxis, Chemotherapy, Gadoteridol, business.industry, Anaphylactic reactions, medicine.disease, chemistry, business, medicine.drug
Published
2022
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4. IgE-Mediated Sensitization to Galactose-α-1,3- Galactose (α-Gal) in Urticaria and Anaphylaxis in Spain: Geographical Variations and Risk Factors

Author

A García Moral, A M Soriano Galarraga, Angel Ferrer, Carlos H. Larramendi, M C Diéguez, E González Mancebo, A Beristain, Mar Guilarte, Julián Azofra, M I Alvarado, G Sosa, R Núñez Orjales, Begoña García, M D Alonso Díaz de Durana, Joan Bartra, and M B Mateo Borrega

Subjects
Adult, Male, 0301 basic medicine, medicine.medical_specialty, Allergy, Urticaria, Immunology, Disaccharides, Immunoglobulin E, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, Epidemiology, medicine, Humans, Immunology and Allergy, Ingestion, Anaphylaxis, Sensitization, Geography, biology, business.industry, Case-control study, Allergens, Middle Aged, medicine.disease, 030104 developmental biology, medicine.anatomical_structure, Spain, Tick-Borne Diseases, 030220 oncology & carcinogenesis, biology.protein, Population study, Female, business, Food Hypersensitivity
Abstract

Background The objectives of this study were to investigate the prevalence of sIgE to galactose-α-1,3-galactose (α-gal) in individuals with acute urticaria or anaphylaxis from different geographical areas of Spain and to evaluate the relevance of demographics and lifestyle as risk factors for this immune response. Methods Participants were recruited from allergy departments at 14 Spanish hospitals. Patients aged 18 years or older presenting with urticaria or anaphylaxis were enrolled into one of 2 arms: cases and controls. An interviewer-administered questionnaire collecting demographic data, lifestyle habits, and the presence of cofactors was obtained from each participant. sIgE to α-gal and total IgE were determined using ImmunoCAP. sIgE levels ≥0.35 kU/L were considered a positive result. Results The study population comprised 160 cases and 126 controls. The median age was 44 years. The overall prevalence of a positive result of sIgE to α-gal was 15.7%; this was higher in cases (26.3%) than in controls (2.4%). The sIgE anti-α-gal positivity rate ranged from 37.68% (rural) to 15.38% (semiurban), and 7.85% (urban). The rates of positivity were 46.32%, (Northern), 0.72% (Center), and 0% (Mediterranean). A positive result for sIgE to α-gal was associated with a history of tick bites, participation in outdoor activities, pet ownership, and ingestion of mammalian meats or innards before the onset of symptoms. Only alcohol consumption could be implicated as a cofactor. Conclusion Sensitization to α-gal in patients with urticaria or anaphylaxis differs considerably between the 3 geographical areas studied and is related to tick bites.

Published
2019
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5. Tolerability and Immunological Effect of Short Up-Dosing Immunotherapy With 2 Standardized Native Allergen Extracts Derived From the Pollen of Salsola kali and Cupressus arizonica

Author

A Marín de Pablo, E Ibáñez Echevarría, P González Delgado, M D Alonso Díaz de Durana, P Prieto Montaño, M Rodríguez Mosquera, M Antón Gironés, and Montserrat Fernandez-Rivas

Subjects
Adult, Male, Salsola, Cupressus arizonica, medicine.medical_treatment, Immunology, medicine.disease_cause, Allergen, Pollen, Immune Tolerance, medicine, Humans, Immunology and Allergy, Dosing, Immunoglobulin IgE, biology, Traditional medicine, business.industry, Rhinitis, Allergic, Seasonal, Immunotherapy, Allergens, Cupressus, biology.organism_classification, Tolerability, Female, business
Published
2018
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6. Is the ISAC 112 Microarray Useful in the Diagnosis of Pollinosis in Spain?

Author

A Bernard Alonso, C Moya, Laura Sola, F. Feo Brito, Rubén Martínez-Aranguren, Pedro M. Gamboa, Begoña García, Natalia Blanca-López, A Parra, Javier Fernández, Joan Bartra, M D Alonso, Maria L. Sanz, Francisca Gómez, Eloína González-Mancebo, S. Terrados, M I Alvarado, Maria Jose Goikoetxea, [García,BE, Sola,L] ] Allergology Service, Complejo Hospitalario de Navarra, Pamplona, Spain. [García,BE, Martínez-Aranguren,R, Goikoetxea,MJ, Sanz,ML] IdiSNA, Navarra Institute for Health Research, Spain . [Martínez-Aranguren,R, Alonso, B, Sanz,ML] Allergology and Clinical Immunology Department, Clínica Universidad de Navarra, Pamplona, Spain. [Gamboa,P] Allergology Service, Hospital de Basurto, Bilbao, Spain. [Feo Brito,F] Allergology Service, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain. [Bartra,J] Unitat d’Alèrgia Servei Pneumologia i Alèrgia Respiratoria Universitat de Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigaciones Biomédicas en Red de Enfermedades Respiratorias (CIBERES), Barcelona, Spain . [Blanca-López,N] Allergology Service, Hospital Infanta Leonor, Madrid, Spain. [Gómez,F] Allergology Service, IBIMA, Hospital Regional Universitario de Malaga, UMA, Malaga, Spain. [Alvarado,MI] Allergology Service, Hospital Virgen del Puerto, Plasencia, Cáceres, Spain. [Fernández,J] Allergology Service, Hospital General Universitario de Alicante, Alicante, Spain. [Alonso,MD] Allergology Service, Hospital de Alcorcón, Alcorcón, Spain. [Gonzalez-Mancebo,E] Allergology Service, Hospital de Fuenlabrada, Madrid, Spain. [Moya,C] Allergology Service, Complejo Hospitalario Torrecárdenas, Almería, Spain . [Parra,A] Allergology Service, Hospital de A Coruña, A Coruña, Spain. [Terrados,S] Allergology Service, Hospital Universitario Ramon y Cajal, IRYCIS, Madrid, Spain., This research was financially supported by the Carlos III Health Institute (Grant: PI 11/01634), and by grant RD12/0013/00010 from the Spanish Research Network on Adverse Reactions to Allergens and Drugs (RIRAAF, and Red de Investigación de Reacciones Adversas a Alérgenos y Fármacos) of the Carlos III Health Institute.

Subjects
Male, 0301 basic medicine, Allergy, Microarray, Pollination, España, Gene Expression, Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], medicine.disease_cause, Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression [Medical Subject Headings], Trees, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Profilins, Mediana Edad, 0302 clinical medicine, Alérgenos, Grass pollen, Especificidad de la Especie, Organisms::Eukaryota::Plants::Viridiplantae::Streptophyta::Embryophyta::Angiosperms::Poaceae [Medical Subject Headings], Immunology and Allergy, Masculino, Accuracy, Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings], Diseases::Immune System Diseases::Hypersensitivity::Hypersensitivity, Immediate::Respiratory Hypersensitivity [Medical Subject Headings], Polen, Adulto, Femenino, Organisms::Eukaryota::Plants::Trees [Medical Subject Headings], food and beverages, Anatomy::Plant Structures::Plant Components, Aerial::Flowering Tops::Flowers::Germ Cells, Plant::Pollen [Medical Subject Headings], Profilinas, Middle Aged, Humanos, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Sensitivity and Specificity::Predictive Value of Tests [Medical Subject Headings], Inmunoglobulina E, Area Under Curve, Pollen, Hipersensibilidad Respiratoria, Female, Molecular diagnosis, Adult, Área Bajo la Curva, Expresión Génica, Immunology, Check Tags::Male [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Microchip Analytical Procedures::Microarray Analysis [Medical Subject Headings], Poaceae, 03 medical and health sciences, Species Specificity, Predictive Value of Tests, Árboles, Phenomena and Processes::Biological Phenomena::Species Specificity [Medical Subject Headings], Named Groups::Persons::Age Groups::Adult [Medical Subject Headings], Respiratory Hypersensitivity, otorhinolaryngologic diseases, medicine, Humans, In patient, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Serum Globulins::Immunoglobulins::Antibodies::Immunoglobulin Isotypes::Immunoglobulin E [Medical Subject Headings], Cypress, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Sensitivity and Specificity::ROC Curve [Medical Subject Headings], Valor Predictivo de las Pruebas, business.industry, Curva ROC, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Area Under Curve [Medical Subject Headings], Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Cytoskeletal Proteins::Microfilament Proteins::Profilins [Medical Subject Headings], Allergens, Immunoglobulin E, Microarray Analysis, medicine.disease, Spanish population, 030104 developmental biology, Check Tags::Female [Medical Subject Headings], ROC Curve, 030228 respiratory system, Spain, Análisis por Micromatrices, Chemicals and Drugs::Biological Factors::Antigens::Allergens [Medical Subject Headings], business, Pollen allergy
Abstract

Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; BACKGROUND Multiple sensitization is frequent among pollen-allergic patients. The goal of this study was to determine the diagnostic accuracy of the ImmunoCAP ISAC 112 (ISAC112) microarray in allergy to pollen from several taxa and its clinical utility in a Spanish population. METHODS Specific IgE was determined in 390 pollen-allergic patients using the ISAC112 microarray. Diagnostic accuracy (sensitivity, specificity, predictive values, and area under the ROC curve) was calculated for the diagnosis of allergy to pollen from grass (n=49), cypress (n=75), olive tree (n=33), plane tree (n=63), and pellitory of the wall (n=17) and compared with that of the singleplex ImmunoCAP immunoassay. RESULTS The sensitivity of the ISAC112 microarray ranged from 68.2% for allergy to plane tree pollen to 93.9% for allergy to grass pollen. The specificity was >90%. The AUC for the diagnosis of allergy to plane tree pollen was 0.798, whereas the AUC for the remaining cases was ≥0.876. The accuracy of ISAC112 was higher than that of ImmunoCAP for plane tree pollen and similar for the remaining pollens. The frequency of sensitization to most species-specific allergenic components and profilins varied between the different geographical regions studied. A total of 73% of pollen-allergic patients were sensitized to species-specific components of more than 1 pollen type. CONCLUSIONS The ISAC112 microarray is an accurate tool for the diagnosis of allergy to pollen from grass, cypress, olive tree, plane tree, and pellitory of the wall. The features of the ISAC112 microarray are similar or superior (in the case of plane tree pollen) to those of ImmunoCAP. This microarray is particularly useful for the etiologic diagnosis of pollinosis in patients sensitized to multiple pollen species whose pollination periods overlap. Yes

Published
2016
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7. Validation of Recipes for Double-Blind Placebo-Controlled Challenges With Milk, Egg White, and Hazelnut

Author

A Meléndez Baltanás, M. Rodríguez-Alvarez, Eloína González-Mancebo, Montserrat Fernandez-Rivas, N. del Prado, Y García Estringana, B. de la Hoz Caballer, and M D Alonso Díaz de Durana

Subjects
Adult, Male, Visual analogue scale, Immunology, Sensation, Immunologic Tests, Placebo, Sensory analysis, Double blind, 03 medical and health sciences, 0302 clinical medicine, Corylus, Double-Blind Method, Food allergy, Predictive Value of Tests, medicine, Immunology and Allergy, Humans, 030212 general & internal medicine, Food science, Cooking, Egg Hypersensitivity, business.industry, Egg Proteins, Diagnostic test, Reproducibility of Results, Middle Aged, medicine.disease, Milk Proteins, 030228 respiratory system, Patient Satisfaction, Spain, Female, Nut Hypersensitivity, Plant Preparations, Milk Hypersensitivity, business, Triangle test, Egg white
Abstract

Background The double-blind, placebo-controlled food challenge (DBPCFC) is considered the definitive diagnostic test for food allergy. Nevertheless, validated recipes for masking the foods are scarce, have not been standardized, and differ between centers. Sensory evaluation techniques such as the triangle test are necessary to validate the recipes used for DBPCFC. Methods We developed 3 recipes for use in DBPCFC with milk, egg white, and hazelnut and used the triangle test to validate them in a 2-phase study in which 197 volunteers participated. In each phase, participants tried 3 samples (2 active-1 placebo or 2 placebo-1 active) and had to identify the odd one. In phase 1, the 3 samples were given simultaneously, whereas in phase 2, the 3 samples of foods that failed validation in phase 1 were given sequentially. A visual analog scale (VAS) ranging from 1 to 10 was used to evaluate how much participants liked the recipes. Results In phase 1, the egg white recipe was validated (n=89 volunteers, 38.9% found the odd sample, P=.16). Milk and hazelnut recipes were validated in phase 2 (for both foods, n=30 participants, 36.7% found the odd sample, P=.36). Median VAS scores for the 3 recipes ranged from 6.6 to 9.7. Conclusions We used sensory testing to validate milk, egg white, and hazelnut recipes for use in DBPCFC. The validated recipes are easy to prepare in a clinical setting, provide the equivalent of 1 serving dose, and were liked by most participants.

Published
2017

8. Adverse reactions to immunotherapy are associated with different patterns of sensitization to grass allergens

Author

M. D. Alonso, P. Campo, E Laffond, J. Sastre, Alicia Marin, and F. Rodríguez

Subjects
Adult, Male, Adolescent, Drug-Related Side Effects and Adverse Reactions, medicine.medical_treatment, Immunology, Poaceae, Phleum, Young Adult, Grass pollen, otorhinolaryngologic diseases, medicine, Humans, Immunology and Allergy, Drug reaction, Sensitization, Aged, Asthma, biology, business.industry, Rhinitis, Allergic, Seasonal, food and beverages, Immunotherapy, Allergens, Middle Aged, biology.organism_classification, medicine.disease, Systemic reaction, medicine.anatomical_structure, Desensitization, Immunologic, Female, business
Abstract

The aim of the study was to investigate whether adverse drug reactions (ADRs) during immunotherapy with a grass extract (AVANZ® Phleum, ALK-Abelló) are related to the different patterns of sensitization of patients to grass allergens. A total of 192 patients with rhinitis and/or asthma sensitized to grass pollen received a 4-week updosing with five injections. ADRs were evaluated following EAACI guidelines. A total of 432 ADRs in 133 (69%) patients were recorded, 64% local and 31% systemic. There was a significant association between the number of grass allergens that sensitized the patients and the total number of ADRs (P = 0.004) occurred locally (P = 0.003) and systemically (P = 0.01). Sensitization to Phl p1 + Phl p5 or Phl p1 + Phl p5 + Phl p12 was significantly associated with a higher frequency of local or systemic reactions (P = 0.001, both). Different patterns of sensitization to grass allergens may potentially be considered a risk marker to the development of ADRs to immunotherapy.

Published
2015
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9. Randomized double-blind, placebo-controlled trial of sublingual immunotherapy with a Pru p 3 quantified peach extract

Author

Ana I. Tabar, Montserrat Fernandez-Rivas, M. D. Alonso Díaz de Durana, S. Garrido Fernández, Eloína González-Mancebo, S. Martin, J. A. Nadal, Domingo Barber, Rico P, and Blanca E. García

Subjects
Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Immunology, Administration, Sublingual, Placebo-controlled study, Immunoglobulin E, Gastroenterology, Sublingual administration, law.invention, Double-Blind Method, Randomized controlled trial, Food allergy, law, Internal medicine, medicine, Humans, Immunology and Allergy, Adverse effect, Plant Proteins, Skin Tests, Desensitization (medicine), biology, business.industry, Allergens, Antigens, Plant, medicine.disease, Clinical trial, Desensitization, Immunologic, Immunoglobulin G, biology.protein, Female, Prunus, business, Food Hypersensitivity
Abstract

Background: Peach allergy is highly prevalent in the Mediterranean area; it is persistent and potentially severe, and therefore a prime target for immunotherapy. We aimed to study the efficacy and safety of sublingual immunotherapy (SLIT) with a peach extract quantified in mass units for Pru p 3, the peach lipid transfer protein. Methods: Randomized, double-blind, placebo-controlled (DBPC) clinical trial. The main efficacy outcome was the change in the response to a DBPC food challenge (DBPCFC) with peach. Secondary efficacy outcomes were the changes in skin prick test (SPT), and in specific immunoglobulin E (IgE) and IgG4 to Pru p 3. Tolerance was assessed with a careful recording of adverse events. Results: After 6 months of SLIT, the active group tolerated a significantly higher amount of peach (three- to ninefold), presented a significant decrease (5.3 times) in SPT, and a significant increase in IgE and IgG4 to Pru p 3. No significant changes were observed within the placebo group. Statistically significant inter-group differences were only observed in the SPT and IgG4 responses. No serious adverse events were reported. Systemic reactions were mild, and observed with a similar frequency in both groups. Local reactions were significantly more frequent in the active group (three times) and 95% of them restricted to the oral cavity. Conclusion: In this first exploratory clinical trial, SLIT for peach allergy seems to be a promising therapeutic option that could modify the clinical reactivity of the patients to peach intake and the underlying immunological response with a good tolerance.

Published
2009
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11. Minimum energy configurations of small bidisperse bubble clusters

Author

Maria Fátima Vaz, Simon Cox, and M. D. Alonso

Subjects
Physics, Theoretical physics, Bubble, Cluster (physics), General Materials Science, Condensed Matter Physics, Energy (signal processing), Computational physics
Abstract

We consider two-dimensional foam clusters consisting of small collections of N bubbles with two different areas. Different arrangements of these bidisperse clusters were found experimentally for each N. Calculation of their perimeter allowed us to compare the energy of each cluster, giving candidates to the minimal energy arrangement. The number of possible clusters is discussed and the calculated energies are compared with existing approximations.

Published
2004
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12. Fourth meeting of the European Neurological Society 25–29 June 1994 Barcelona, Spain

Author

H. Hattig, C. Delli Pizzi, M. C. Addonizio, Michelle Davis, A. R. Giovagnoli, L. Florensa, M. Roth, J. de Kruijk, Francisco Lacruz, Ph. Dewailly, A. Toygar, C. Avendano, P.P. De Deyn, J. F. Hurtevent, F. Lomeila, T. W. Wong, Gordon T. Plant, M. Bud, H. J. Willison, DH Miller, D. W. Langdon, R. Cioni, J. Servan, A. Kaygisiz, E. Racadot, D. B. Schens, E. Picciola, L. Falip, C. Bouchard, J. Jotova, A. Jorge-Santamaria, P. Misra, A. Dufour, C. P. Panagopoulos, A. Venneri, B. Sredni, B. Angelard, M. Janelidze, M. Carreno, J. Obenberger, J. Pouget, H. W. Moser, R. Kaufmann, J. A. Molina, D. Linden, A. Martin Urda, E. Uvestad, A. Krone, J. P. Cochin, J. Mallecourt, A. Cambon-Thomsen, K. Violleau, P. Osschmann, A. M. Durocher, E. Bussaglia, D. M. Danielle, H. Efendi, C. Van Broeckhoven, K. G. Jordan, W. Rautenberg, C. Iniguez, J. M. Delgado, Graham Watson, M. Lawden, Gareth J. Barker, K. Stiasny, James T. Becker, G. Campanella, E. Peghi, A. Poli, A. Haddad, T. Yamawaki, Giacomo P. Comi, S. Sotgiu, B. Ersmark, A. Pomes, M. Ziegler, P. Ferrante, P. Ruppi, H. KuÇukoglu, R. Bouton, U. K. Rinne, P. Vieregge, M. Dary, P. Giunti, Peter J. Goadsby, S. Jung, E. Secor, A. Steinberg, N. Vila, M. A. Hernandez, M. Cursi, A. Enqelhardt, A. Engelhardt, J. Veitch, F. Di Silverio, F. Arnaud, B. Neundörfer, R. Brucher, Dominique Caparros-Lefebvre, B. Meyer, Marianne Dieterich, M. H. Snidaro, R. Gomez, R. Cerbo, M. Ragno, J. M. Vance, S. Nemni, A. Caliskan, F. Barros, I. Velcheva, D. Ceballos-Baumann, V. Barak, A. Avila, N. Antonova, F. Resche, S. Pappata, L. Varela, S. R. Silveira Santos, A. Cammarota, L. Naccache, Y. Nara, E. Tournier-Lasserves, R. Mobner, T. Chase, A. Ensenyat, J. Ulrich, G. Giegerich, M. Rother, M. Revilla, N. Nitschke, K. Honczarenko, E. Basart Tarrats, J. Blin, B. Jacob, J. Santamaria, S. Knezevic, J. L. Castillo, M. Antem, J. Colomer, O. Busse, Didier Hannequin, S. Carrier, J. B. Ruidavets, C. Rozman, J. Bogoussslavsky, J. Pascual Calvet, E. Monros, J. M. Polo, M. Zucconl, Javier Muruzabal, R. R. Allen, R. Rivolta, K. Haugaard, A. Nespolo, K. Hoang-Xuang, G. Bussone, T. Avramidis, E. Corsini, Christiana Franke, T. Vinogradova, H. Boot, K. Vestergaard, G. H. Jansen, N. Argentino, M. Raltzig, W. Linssen, Mark B. Pepys, P. Roblot, L. Lauritzen, E. Fainardi, D. Morin, T. X. Arbizu Urdiain, J. Wollenhaupt, S. Bostantjopoulou, G. Pavesi, A. D. Forman, Giovanni Fabbrini, D. Jean, J. J. Archelos, M. I. Blanchs, M. Del Gobbo, Anna Carla Turconi, Ch. Derouesné, Elio Scarpini, A. Visbeck, P. Castejon, J. P. Renou, F. Mounier-Vehier, G. Potagas, Ch. Duyckaerts, A. Filla, R. Schneider, G. Ronen, K. Nagata, J. P. Vedel, A. Henneberg, G. van Melle, C. Baratti, H. Knott, M. C. Prevett, A. Bes, B. Metin, Jos V. Reempts, L. Martorell, Mefkure Eraksoy, H. O. Handwerker, D. S. Younger, O. Oktem, D. Frongillo, C. Soriano-Soriano, L. Niehaus, F. Zipp, A. Tartaro, S Newman, R. H. Browne, P. Davous, R. Sanchez, M. Muros, M. E. Kornhuber, A. Lavarone, M. Mohr, M. R. Garcia, S. Russell, H. Kellar-Wood, M. R. Tola, B. Ostermeyer, Ch. Tzekov, K. Sartor, E. B. Ringelstein, P. P. Gazzaniga, Paul Krack, H. Fidaner, H. Rico, T. Dbaiss, F. Alameda, E. Torchiana, L. Rumbach, I. Charques, J. M. Bogaard, C. D. Frith, L. J. Rappelle, R. Brenner, A. Joutel, K. Fuxe, G. HÄcker, M. J. Blaser, J. Valls-SolÇ, G. Ulm, M. Alberdi, A. Bock, F. W. Bertelsmann, U. Wieshmann, J. Visa, J. R. Lupski, D. D'Amico, L. M. P. Ramos, A. A. Vanderbark, R. Horn, M. Warmuth, Dietmar Kühne, Mark S. Palmer, C. Ehrenheim, E. Canga, S. Viola, O. Scarpino, P. Naldi, R. Almeida, A. A. Raymond, J. Gamez, Stephan Arnold, A. DiGiovanni, J. Dalmau, C. C. Chari, H. F. Beer, J. C. Koetsier, J. Iriarte, E. Yunis, J. Casadevall, E. Le Guern, E. Stenager, S. R. Benbadis, J. M. Warter, F. Burklin, I. Theodorou, L. Johannesen, G. A. Graveland, X. Leclerc, I. Vecchio, L. Ozelius, G. Nicoletti, R. K. Gherardi, E. Esperet, M. L. Delodovici, F. Cattin, F. Paiau, Giorgio Sacilotto, C. A. J. Broere, D. Chavdarov, J. P. Willmer, C. H. Hawkes, Th. Naegele, E. Ellie, E. Dartigues, M. J. Guardiola, S. Hesse, Z. Levic, Marco Rovaris, P. Saugeir-Veber, B. A. Yaqub, H. F. Durwen, R. Larumbe, J. Ballabrina, M. Sendtner, J. Röther, M. Horstink, C. Kluglein, M.P. Montesi, H. Apaydin, J. Montoya, E. Waubant, Ch. Verellen-Dunoulin, A. Nicolai, J. Lopez-Delval, R. Lemon, G. Cantinho, E. Granieri, A. Zeviani, Wolfgang H. Oertel, U. Ficola, V. Di Piero, V. Fragola, K. Sabev, M. V. Guitera, I. Turki, F. Bolgert, P. Ingrand, J. M. Gobernado, L. M. E. Grimaldi, S. Baybas, B. Eymard, Y. Rolland, Y. Robitaille, Ta. Pampols, P. J. Koehler, A. Carroacedo, J. Vilchez, S. Di Vittorio, I. R. Rise, T. Nagy, M. Kuffner, E. Palazzini, A. Ott, J. Pruim, T. X. Arbizu, E. Manetti, C. Cervera, S. Felber, G. Gursoy, J. Scholz, G. A. Buscaino, M. S. Chen, A. Pascual, J. Hazan, J. U. Gajda, J. G. Cea, G. Bottini, G. Damalik, F. Le Doze, G. Bonaldi, J. M. Hew, C. Messina, A. M. Kennedy, J. M. Carney, N. M. F. Murray, M. Parent, M. Koepp, V. Dimova, D. De Leo, K. Jellinger, G. Salemi, S. Mientus, M. L. Hansen, F. Mazzucchelli, J. Vieth, M. Mauri, E. Bartels, L. Johannsen, C. Humphreys, J. Emile, D. N. Landon, E. Kansu, R. Sanchez-Pernaute, Rsj Frackowiak, M. Gonzalez Torres, L. Oller, C. Machedo, J. Kother, M. Billiard, H. Durak, T. Schindler, A. Frank, A. Uncini, A. Sbriccoli, C. Farinas, D. W. Paty, N. Fast, A. T. Zangaladze, A. Kerkhofs, J. M. Pino Garcia, I. De la Fuente, B. Marini, L. Gomez, I. Rubio, Alessandra Bardoni, C. Brodie, P. Acin, U. Sliwka, S. A. Hawkins, S. Tardieu, F. Vitullo, J. M. Pereira Monteino, R. Gagliardi, T. Jezewski, A. Cano, T. Lempert, F. Abad Alegria, G. Rotondo, D. Ince, C. Martinez Parra, Y. Huang, H. Luders, Y. Steinvil, F. G. A. Van Der Meche, R. Bianchi, A. Sanchez, T. Sevilla, J. M. Ketelslegers, A. Domzal-Stryga, M. Pandolfo, M. O. Josse, K. W. Neff, I. Blanco, G. W. Bruyn, O. W. Witte, J. L. Thibault, G. Andersen, J. Pariset, A. Marcone, R. J. M. 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Garcia de Yebenes, N. K. Olsen, P. Hitzenberger, S. Einius, Aj Thompson, Ch. J. Vecht, T. Crepin-Leblond, Klaus L. Leenders, A. Di Muzio, L. Georgieva, René Spiegel, K. Sabey, D. Ménégalli, J. Meulstee, U. Liszka, P. Giral, C. Sunol, J. M. Espadaler, A. D. Crockar, K. Varli, G. Giraud, P. J. Hülser, A. Benazzouz, A. Reggio, M. Salvatore, K. Genc, M. Kushnir, S. Barbieri, J. Ph. Azulay, M. Gianelli, N. Bathien, A. AlMemar, F. Hentati, I. Ragueneau, F. Chiarotti, R. C. F. Smits, A. K. Asbury, F. Lacruz, B. Muller, Alan J. Thompson, Gordon Smith, K. Schmidt, C. Daems Monpeun, Juergen Weber, A. Arboix, G. R. Fink, A. M. Cobo, M. Ait Kaci Ahmed, E. Gencheva, Israel-Biet, G. Schlaug, P. De Jonghe, Philip Scheltens, K. Toyka, P. Gonzalez-Porque, A. Cila, J. M. Fernandez, P. Augustin, J. Siclia, S. Medaglini, D. E. Ziogas, A. Feve, L. Kater, G. J. E. Rinkel, D. Leppert, Rüdiger J. Seitz, S. Ried, C. Turc-Carel, G. Smeyers, F. Godinho, M. Czygan, M. Rijntjes, E. Aversa, M. Frigo, Leif Østergaard, J. L. Munoz Blanco, A. Cruz-Matinez, J. De Reuck, C. Theillet, T. Barroso, V. Oikonen, Florence Lebert, M. Kilinc, C. Cordon-Cardon, G. Stoll, E. Thiery, F. Pulcinelli, J. Solski, M. Schmiegelow, L. J. Polman, P. Fernandez-Calle, C. Wikkelso, M. Ben Hamida, M. Laska, E. Kott, W. Sulkowski, C. Lucas, N. M. Bornstein, D. Schmitz, M. W. Lammers, A. de Louw, R. J. S. Wise, P. A. van Darn, C. Antozzi, P. Villanueva, P. H. E. Hilkens, C. Constantin, W. Ricart, A. Wolf, M. Gamba, P. Maguire, Alessandro Padovani, B. M. Patten, Marie Sarazin, H. Ackermann, L. Durelli, S. Timsit, Sebastian Jander, B. W. Scheithauer, G. Demir, J. P. Neau, P. Barbanti, A. Brand, N. AraÇ, V. Fischer-Gagnepain, R. Marchioli, G. Serratrice, C. Maugard-Louboutin, G. T. Spencer, D. Lücke, G. Mainardi, K. Harmant Van Rijckevorsel, G. B. Creel, R. Manzanares, Francesco Fortunato, A. May, J. Workman, K. Johkura, E. Fernandez, Carlo Colosimo, L. Calliauw, L. Bet, Félix F. Cruz-Sánchez, M. Dhib, H. Meinardi, F. Carrara, J. Kuehnen, C. Peiro, H. Lassmann, K. Skovgaard Olsen, A. McDonald, L. Sciulli, A. Cobo, A. Monticelli, B. Conrad, J. Bagunya, J. Benitez, V. Desnizza, B. Dupont, O. Delrieu, D. Moraes, J. J. Heimans, F. Garcia Rio, M. Matsumto, A. Fernandez, R. Nermni, R. Chalmers, M. J. Marchau, F. Aguado, P. Velupillai, P. J. Martin, P. Tassan, V. Demarin, A. Engelien, T. Gerriets, Comar, J. L. Carrasco, J. P. Pruvo, A. Lopez de Munain, D. Pavitt, J. Alarcon, Chris H. Polman, B. Guldin, N. Yeni, Hartmut Brückmann, N. Wilczak, H. Szwed, R. Causaran, G. Kyriazis, M. E. Westarp, M. Gasparini, N. Pecora, J. M. Roda, E. Lang, V. Scaioli, David R. Fish, D. Caputo, O. Gratzl, R. Mercelis, A. Perretti, G. Steimetz, I. Link, C. Rigoletto, A. Catafau, G. Lucotte, M. Buti, G. Fagiolari, A. Piqueras, C. Godinot, J. C. Meurice, Erodriguez J. Dominigo, F. Lionnet, H. Grzelec, David J. Brooks, P. M. G. Munro, F. X. Weilbach, M. Maiwald, W. Split, B. Widjaja-Cramer, V. Ozturk, J. Colas, E. Brizioli, J. Calleja, L. Publio, M. Desi, R. Soffietti, P. Cortinovis-Tourniaire, E. F. Gonano, G. Cavaletti, S. Uselli, K. Westerlind, H. Betuel, C. O. Dhiver, H. Guggenheim, M. Hamon, R. Fazio, P. Lehikoinen, A. Esser, B. Sadzot, G. Fink, Angelo Antonini, D. Bendahan, V. Di Carlo, G. Galardi, A. F. Boller, M. Aksenova, Del Fiore, V. de la Sayette, H. Chabriat, A. Nicoletti, A. Dilouya, M. L. Harpin, E. Rouillet, J. Stam, A. Wolters, M. R. Delgado, Eduardo Tolosa, G. Said, A. J. Lees, L. Rinaldi, A. Schulze-Bonhage, MA Ron, C. Lefebvre, E. W. Radü, R. Alvarez, M. L. Bots, P. Reganati, S. Palazzi, A. Poggi, N. J. Scolding, V. Sazdovitch, T. Moreau, E. Maes, M. A. Estelies, P. Petkova, Jose-Felix Marti-Masso, G De La Meilleure, N. Mullatti, M. Rodegher, N. C. Notermans, T. A. T. Warner, S. Aktan, J. P. Louboutin, L. Volpe, C. Scheidt, W. Aust, C. M. Wiles, U. Schneider, S. K. Braekken, W. R. Willems, K. Usuku, Peter M. Rothwell, C. Talamon, M. L. Sacchetti, A. Codina, M. H. Marion, A. Santoro, J. Roda, A. Bordoni, D. J. Taylor, S. Ertas, H. H. Emmen, J. Vichez, V. BesanÇon, R. E. Passingham, M. L. Malosio, A. Vérier, M. Bamberg, A. W. Hansen, E. Mostacero, G. Gaudriault, Marie Vidailhet, B. Birebent, K. Strijckmans, F. Giannini, T. Kammer, I. Araujo, J. Nowicki, E. Nikolov, A. Hutzelmann, R. Gherardi, J. Verroust, L. Austoni, A. Scheller, A. Vazquez, S. Matheron, H. Holthausen, J. M. Gerard, M. Bataillard, S. Dethy, V. H. Patterson, V. Ivanez, N. P. Hirsch, F. Ozer, M. Sutter, C. Jacomet, M. Mora, Bruno Colombo, A. Sarropoulos, T. H. Papapetropoulos, M. Schwarz, D. S. Dinner, N. Acarin, B. Iandolo, J. O. Riis, P. R. J. Barnes, F. Taroni, J. Kazenwadel, L. Torre, A. Lugaresi, I. L. Henriques, S. Pauli, S. Alfonso, Pedro Quesada, A. S. T. Planting, J. M. Castilla, Thomas Gasser, M. Van der Linden, A. Alfaro, E. Nobile-Orazio, G. Popova, W. Vaalburg, F. G. A. van der Mech, L. Williams, F. Medina, J. P. Vernant, J. Yaouanq, B. Storch-Hagenlocher, A. Potemkowski, R. Riva, M. H. Mahagne, M. Ozturk, Ve. Drory, N. Konic, C. Jungreis, A. Pou Serradell, J. L. Gauvrit, G. J. Chelune, S. Hermandez, T. Dingus, L. Hewer, Ch. Koch, M. N. Metz-Lutz, G. Parlato, M. Sinaki, Charles Pierrot-Deseilligny, H. C. Diener, J. Broeckx, J. Weill-Fulazza, M. L. Villar, M. Rizzo, O. Ganslandt, C. Duran, N. A. Fletcher, G. Di Giovacchino, Susan T. Iannaccone, C. Kolig, N. Fabre, H. A. Crockard, Rita Bella, M. Tazir, E. Papagiannuli, K. Overgaard, Emma Ciafaloni, I. Lorenzetti, F. Viader, P. A. H. Millac, I. Montiel, L. H. Visser, M. Palomar, P. L. Murgia, H. Pedersen, Rafael Blesa, S. Seddigh, W. O. Renier, I. Lemahieu, H. M. L. Jansen, L. Rosin, J. Galofre, K. Mattos, M. Pondal, G. M. Hadjigeorgiou, D. Francis, L. Cantin, D. Stegeman, M. Rango, A. B. M. F. Karim, S. Schraff, B. Castellotti, I. Iriarte, E. Laborde, T. J. Tjan, R. Mutani, D. Toni, B. Bergaasco, J. G. Young, C. Klotzsch, A. Zincone, X. Ducrocq, M. Uchuya, O. J. Kolar, A. Quattrone, T. Bauermann, Nereo Bresolin, J. Vallée, B. C. Jacobs, A. Campos, Werner Poewe, J. A. Villanueva, A. W. Kornhuber, A. Malafosse, E. Diez-Tejedor, G. Jungreia, M. J. A. Puchner, A. Komiyama, O. Saribas, V. Volpini, L. Geremia, S. Bressi, A. Nibbio, Timothy E. Bates, T. z. Tzonev, E. Ideman, G. A. Damlacik, G. Martino, G. Crepaldi, T. Martino, Kjell Någren, E. Idiman, D. Samuel, J. M. Perez Trullen, Y. van der Graaf, J. O. Thorell, M. J. M. Dupuis, E. Sieber, R. D'Alessandro, C. Cazzaniga, J. Faiss, A. Tanguy, A. Schick, I. Hoksergen, A. Cardozo, R. Shakarishvili, G. K. Wennlng, J. L. Marti-Vilalta, J. Weissenbach, I. L. Simone, Amalia C. Bruni, Darius J. Adams, C. Weiller, A. Pietrangeli, F. Croria, C. Vigo-Pelfrey, Patricia Limousin, A. Ducros, G. Conti, O. Lindvall, E. Richter, M. Zuffi, A. Nappo, T. Riise, J. Wijdenes, M. J. Fernandez, J. Rosell, P. Vermersh, S. Servidei, M. S. C. Verdugo, F. Gouttiere, W. Solbach, M. Malbezin, I. S. Watanabe, A. Tumac, W. I. McDonald, D. A. Butterfield, P. P. Costa, F. deRino, F. Bamonti, J. M. Cesar, C. H. Lahoz, I. Mosely, M. Starck, M. H. Lemaitre, K. M. Stephan, S. Tex, R. Bokonjic, I. Mollee, L. Pastena, M. Gutierrez, F. Boiler, M. C. Martinez-Para, M. Velicogna, O. Obuz, A. Grinspan, M. Guarino, L. M. Cartier, E. Ruiz, D. Gambi, S. Messina, M. Villa, Michael G. Hanna, J. Valk, Leone Pascual, M. Clanet, Z. Argov, B. Ryniewicz, E. Magni, B. Berlanga, K. S. Wong, C. Gellera, C. Prevost, F. Gonzalez-Huix, R. Petraroli, J. E. G. Benedikz, I. Kojder, C. Bommelaer, L. Perusse, M. R. Bangioanni, Guy M. McKhann, A. Molina, C. Fresquet, E. Sindern, Florence Pasquier, M. J. Rosas, M. Altieri, O. Simoncini, M. Koutroumanidis, C. A. F. Tulleken, M. Dary-Auriol, S. Oueslati, H. Kruyer, I. Nishisho, C. R. Horning, A. Vital, G. V. Czettritz, J. Ph. Neau, B. Mihout, A. Ameri, M. Francis, S. Quasthoff, D. Taussig, S. Blunt, P. Valentin, C. Y. Gao, O. Heinzlef, H. d'Allens, C. Coudero, M. Erfas, G. Borghero, P. J. Modrego Pardo, M. C. Patrosso, N. L. Gershfeld, P. A. J. M. Boon, O. Sabouraud, M. Lara, J. Svennevig, G. L. Lenzi, A. Barrio, H. Villaroya, JosÇ M. Manubens, O. Boespflug-Tanguy, M. Carreras, D. A. Costiga, J. P. Breux, S. Lynn, C. Oliveras Ley, A. G. Herbaut, J. Nos, C. Tornali, Y. A. Hekster, J. L. Chopard, J. M. Manubens, P. Chemouilli, A. Jovicic, F. Dworzak, S. Smirne, S. E. Soudain, B. Gallano, D. Lubach, G. Masullo, G. Izquierdo, A. Pascual Leone Pascual, A. Sessa, V. Freitas, O. Crambes, L. Ouss, G. W. Van Dijk, P. Marchettini, P. Confalonieri, M. Donaghy, A. Munnich, M. Corbo, and M. E. L. van der Burg

Subjects
Neurology, business.industry, Media studies, Library science, Medicine, Neurology (clinical), business
Published
1994
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13. Evaluation of Basophil Activation in Mastocytosis with Hymenoptera Venom Anaphylaxis

Author

Almudena Matito, M. L. Sanz, D. González-de-Olano, Iván Álvarez-Twose, Laura Sánchez-Muñoz, Luis Escribano, A. Vega Castro, A. Orfao, José Mário Morgado, B. de la Hoz Caballer, M D Alonso Díaz de Durana, and M. I. Esteban López

Subjects
Adult, Male, Histology, medicine.medical_treatment, Basophil Degranulation Test, Sensitivity and Specificity, Culprit, Pathology and Forensic Medicine, Mastocytosis, Systemic, medicine, Animals, Humans, Systemic mastocytosis, Anaphylaxis, Arthropod Venoms, Sensitization, Aged, CD63, business.industry, fungi, Cell Biology, Immunotherapy, Immunoglobulin E, Middle Aged, medicine.disease, Hymenoptera, Basophils, Basophil activation, medicine.anatomical_structure, Immunology, Female, Bone marrow, business
Abstract

[Background]: Basophil activation tests (BATs) have been demonstrated to be useful in detecting IgE-mediated sensitization by measuring basophil activation surface markers (CD63 and CD203c). Hymenoptera venom is one of the best known mediators-release trigger in patients with systemic mastocytosis (SM). The aim of this study was to investigate the use of BATs as an additional diagnostic tool in patients with mastocytosis suffering from hymenoptera venom anaphylaxis (HVA). [Methods]: A total of 22 patients with history of HVA and SM, together with a group of 11 patients with HVA in whom SM was ruled out after a complete bone marrow study, were analyzed. [Results]: Among 11 SM patients who had specific serum IgE (sIgE) against hymenoptera venom and an evaluable BAT, a positive BAT was found in nine. Additionally, a positive BAT was detected in three of seven patients who had no sIgE. These three patients had low levels of total IgE compared with control population (mean of 20 vs. 78 IU/mL); one had discontinued immunotherapy after 5 years, when sIgE levels had turned negative, and, in the other two patients, BAT identified the culprit insect. [Conclusions]: BAT is a useful complementary diagnostic tool to sIgE in mastocytosis patients with HVA, and it may contribute to predict or confirm these nearly fatal reactions, especially before discontinuing venom immunotherapy in patients who are negative for skin tests or sIgE or display low total IgE levels; in such cases, it also provides evidence on the culprit insect prompting HVA. (C) 2010 International Clinical Cytometry Society, SEAIC 2006; Grant sponsor: Fondo de Investigaciones Sanitarias of the Ministerio de Sanidad y Consumo; Grant number: PS 09/00032; Grant sponsor: Junta de Comunidades de Castilla La Mancha; Grant numbers: FISCAM 2007/36 and FISCAM 2008/46.

Published
2011

14. Long-term outcomes in patients with schizophrenia treated with risperidone long-acting injection or oral antipsychotics in Spain: results from the electronic Schizophrenia Treatment Adherence Registry (e-STAR)

Author

J M, Olivares, A, Rodriguez-Morales, J, Diels, M, Povey, A, Jacobs, Z, Zhao, A, Lam, J C, Villalobos Vega, J Alonso, Cuéllar, F J Alberca, de Castro, C Morillo-Velarde, Quintero, J F Román, Martíin, P Tabares, Domínguez, J L Prados, Ojeda, S Sanz, Cortés, F I Mata, Cala, C Gutiérrez, Marín, L Moyano, Castro, M A Haza, Duaso, J Requena, Albarracín, G Narbona, Vergara, A Fernández, Benítez, F Mayoral, Cleries, J M García-Herrera, Pérez-Brian, A Bordallo, Aragón, J C Rodríguez, Navarro, J A Algarra, Biedma, R Bravo, de Pedro, J F Delgado, González, M E Jaén, López, H Díaz, Moreno, J A Soto, López, E Ojeda, Rodríguez, C Martínez, de Hoyos, M Pardilla, Sacristán, M D Molina, Martín, E Martín, Ballesteros, P A Sopelana, Rodríguez, L Fernández, Menéndez, R Santos, Rivas, P, del Pino Cuadrado, J Correas, Lauffer, J J Rodríguez, Solano, J M Fernández, Martínez, F García, Solano, P García-Lamberde, Rodríguez, J A Romero, Rodríguez, T Rodríguez, Cano, M Ducaju, Fortacin, J M Blanco, Lobeiras, J M Piñeiro, Sampedro, A Pérez, Bravo, A Fernández, Pellicer, M D Alonso, López, J Fraga, Liste, M Riobo, Fernández, A Casas, Losada, R Vazquez-Noguerol, Mendez, S Agra, Romero, J J Blanco, Blanco, I Tortajada, Bonaselt, M C García, Mahia, E Ferrer Gómez, del Valle, P Quiroga, Yañez, M Gelabert, Camarasa, J A Barbado, Alonso, G Florez, Mendez, F Doce, Feliz, M A López, Lamela, M Vega, Piñero, P Fuentes, Alvarado, I López, Gómez, P Fadon, Martín, J L Santos, Gómez, A García, López, A Rodríguez, Jiménez, A Escudero, Nafs, N Casas, Barquero, R Fernández-Villamor, Ortiz, J L Velez, Noguera, P Ruiz, Carrasco, J Martín, Muñoz, M Masegoza, Palma, C Marín, Hortelano, L Sánchez, Bonome, J Sánchez, Sevilla, J M Mongil San, Juan, J M García, Ramos, J L Vallejo, Muñoz, J Elorza, Guisasola, L Santamaria, Vazquez, F Campo, Guerras, F J Arrufat, Nebot, F J Baron, Fernández, A L Palomo, Nicolau, R Catala, Subirats, M Messays, Kidias, V Fabregat, Navarro, B Frades, García, F Mejias, del Rosal, T, de Vicente Muñoz, J Año, Ballester, P Malabia, Lieb, A Delgado, Martel, E Roca, Bea, I Grau, Joaquim, F Boatas, Enjuanes, M Bañuelos, Piñol, E Fontova I, Carbonell, R Martín, Muñoz, C Argila, Giribets, L Albages, Sans, A Serrano, Blanco, M Arcega, Felipe, P González, Muñoz, A Pons, Villanueva, M Bernardo, Arroyo, R Coronas, Borri, S Miret, Fallada, M Celma, Merola, E Parellada, Rodon, J R Pigem, Palmes, E Pérez, Martínez, J Matarredona, Catala, A Sandoval, Coca, F Pascual, Ferrandiz, E Ferrandiz, Paya, G Iturri, Caballero, A Franco, Bonet, J Fluvia, Figueras, P Moreno, Pagador, M Medina, Garibo, V Pérez, Camo, C Sanz, Carrillo, C Pelegrin, Valero, F J Caro, Rebollo, J, García Campayo, J M Sala, Sala Ayma, M Martínez, Roig, M A, de Uña Mateos, R García, Bertolin, A Martín, García, F Jiménez, Mazo, J L Galvez, Velasco, L Santa Maria, Pérez, C Jiménez, Casado, J J Mancheño, Barba, M Conde, Diaz, J P Alcon, Rubio, A Soler, Mandoli, A Uson, Herrero, A Rodríguez, Martínez, P Salgado, Serrano, E Nieto, Rodríguez, J Segui, Montesinos, J Ferragud, Macia, A Mateos, Mateos Marcos, J V Pérez-Fuster, Soto, M Verdaguer, Dumont, J Parra, Pagan, V Balanza, Martínez, M, Santiuste de Pablos, C Espinosa, Delgado, M D Martínez, Quiles, F J Manzanera, López, P Pozo, Navarro, A Micol, Torres, F J Martínez, Ingles, J M Salmeron, Arias-Camison, J C López, Manzano, R Villanueva, Peña, G Petersen, Guitarte, H Blasco, Fontecilla, J Barjau, Romero, R Sanz, Gil, J Marín, Lozano, L Donaire, Adanez, I, Zarranz Herrera-Oria, J Pérez, Jiménez, F Carrato, Vaz, O Sanz, García, C Contreras, Anton, R Reixach, Casula, M C Natividad, Hernandez, F Teba, Escabias, J Rodríguez, Torresano, A Huidobro, Pérez-Villamil, L, Estevez, M Aragües, Figuero, A, Muñoz de Morales, J L Rodríguez, Calvin, M Delgado, Criado, V Molina, Rodríguez, E Balbo, Ambrosolio, P M Holgado, Madera, G Ponce, Alfaro, M M Rojas, Vidal, A García, Valtuille, O, Ruiz, G Lucas, Cabornero, M, Echevarria Martínez de Bujo, M J Maicas, Mallen, J Santandreu, Puigros, A Liñana, Martorell, A Clar, Forteza, E Rodríguez, Arrebola, M, Rodríguez de la Torre, C G Anton, Saiz, C, Bardolet I Casas, E Rodríguez, Linde, R, De Arce Cordon, E M Padial, Molina, F J Ruiz, Carazo, J J Muro, Romero, D Vico, Cano, M Soria, Dorado, S Campos, Velazquez, A J Rodríguez, Sánchez, S Ocio, Leon, K Pachas, Sánchez, M Henry, Benitez, A Intxausti, Zugarramurai, M A, Contreras, M, De la Varga González, P Barreiro, Marín, F Gómez, Robina, M Sánchez, García, F J Otero, Pérez, P Cubero, Bros, A Carrillo, Gómez, J, de Dios Molina Martín, J L Carrasco, Perera, M C, Averbach, E Goenaga, Palancares, M T, Gallego de Dios, C Fernández, Rojo, S Sánchez, Iglesias, M I Rubio, Merino, N Prieto, Mestre, A Pérez, Urdaniz, J M Martínez, Sánchez, R Gordo, Seco, J Franco, Muñoz, M Mateos, Agut, M L Blanco, Lozano, F Martín, Herguedas, A Torcal, Pena, J Vicente, García, A Varona, Martínez, O Sanz, Sanz Granado, M A Medina, Fernández, J M Moran, Canseco, P A Megia, López, M A Franco, Martín, J A Espina, Barrio, J Giner, Ubago, M Roca, Bennassar, J M Olivares, Díez, J L Hernandez, Fleta, F Porras, Fortes, C Arango, López, O, Medina, D Figuera, Alvarez, J M Peña, Roca, G Rubio, Valladolid, J A Furquet, Tavera, J A, García-Castrillon Sales, I Batalla, Llordes, C Anchuistegui, Melgarejo, F, Cañas de la Paz, V Vallés, Callol, M Bousoño, García, J Bobes, García, F J Vaz, Leal, E Cáceres, Corrales, E Sánchez, Iglesias, M A Carreiras, Gómez, G García, Serrano, E G Román, Chillarón, F J Samino, Aguado, J J Molina, Castillo, A González, González, J Gallardo, Vázquez, M Bolivar, Peralvarez, M Rios, Diaz, M Ybarzabal, Mesa, F J Acosta, Artiles, M Ajoy, Chao, P, del Rosario Santana, M A García, Escudero, M Molla, Berenguer, J M Bonete, Llacer, J A Juan, Berna, J Barragán, Ortiz, L Tost, Pardell, C, Hernández-Alvarez de Sotomayor, M R Cejas, Méndez, R Cabrera, Garate, B Díaz, Múgica, M Caballero, González, J Pujol, Domingo, C Sáez, Navarro, G Selva, Vera, M A, Cuquerella, J Lonjedo, Monzo, P Cervera, Boada, M F Martín, Pérez, E Carrasco, Parrado, J J Yañez, Sánchez, and J Calvo, Fernández

Subjects
Olanzapine, Adult, Male, medicine.medical_specialty, medicine.drug_class, medicine.medical_treatment, Atypical antipsychotic, Administration, Oral, Injections, Intramuscular, Patient Readmission, law.invention, Medication Adherence, 03 medical and health sciences, Benzodiazepines, 0302 clinical medicine, Randomized controlled trial, law, Internal medicine, medicine, Humans, Prospective Studies, Registries, Prospective cohort study, Antipsychotic, Psychiatric Status Rating Scales, Risperidone, business.industry, Dopamine antagonist, Middle Aged, medicine.disease, Long-Term Care, 030227 psychiatry, Surgery, Psychiatry and Mental health, Schizophrenia, Delayed-Action Preparations, Drug Therapy, Combination, Female, Schizophrenic Psychology, business, 030217 neurology & neurosurgery, medicine.drug, Antipsychotic Agents, Follow-Up Studies
Abstract

BackgroundThe electronic Schizophrenia Treatment Adherence Registry (e-STAR) is a prospective, observational study of patients with schizophrenia designed to evaluate long-term treatment outcomes in routine clinical practice.MethodsParameters were assessed at baseline and at 3 month intervals for 2 years in patients initiated on risperidone long-acting injection (RLAI) (n= 1345) or a new oral antipsychotic (AP) (n= 277; 35.7% and 36.5% on risperidone and olanzapine, respectively) in Spain. Hospitalization prior to therapy was assessed by a retrospective chart review.ResultsAt 24 months, treatment retention (81.8% for RLAI versus 63.4% for oral APs,p< 0.0001) and reduction in Clinical Global Impression Severity scores (−1.14 for RLAI versus −0.94 for APs,p= 0.0165) were significantly higher with RLAI. Compared to the pre-switch period, RLAI patients had greater reductions in the number (reduction of 0.37 stays per patient versus 0.2,p< 0.05) and days (18.74 versus 13.02,p< 0.01) of hospitalizations at 24 months than oral AP patients.ConclusionsThis 2 year, prospective, observational study showed that, compared to oral antipsychotics, RLAI was associated with better treatment retention, greater improvement in clinical symptoms and functioning, and greater reduction in hospital stays and days in hospital in patients with schizophrenia. Improved treatment adherence, increased efficacy and reduced hospitalization with RLAI offer the opportunity of substantial therapeutic improvement in schizophrenia.

Published
2008

15. Drainage induced convection rolls in foams I. Convective bubble motion in a tilted tube

Author

Stefan Hutzler, M. D. Alonso, Denis Weaire, and Simon Cox

Subjects
Convection, Total internal reflection, Materials science, Bubble, Biophysics, Surfaces and Interfaces, General Chemistry, Mechanics, Volumetric flow rate, Condensed Matter::Soft Condensed Matter, Physics::Fluid Dynamics, Tilt (optics), General Materials Science, Tube (fluid conveyance), Soft matter, Drainage, Biotechnology
Abstract

When liquid is added to a foam at sufficiently large flow rates, convective bubble motion will occur. Experiments are described in which the foam is confined in a tube which is tilted from the vertical. The theory of foam drainage is applied to this problem to show that the critical angle of tilt theta(c) at which convection occurs is related to the liquid flow-rate Q by theta(c) proportional to Q(-3/4).

Published
2005

16. [Arterial hypertension and intracerebral hemorrhage]

Author

R, Chamarro, A, Ponz, M D, Alonso, R, Gil, and J M, Laínez

Subjects
Hypertension, Humans, Magnetic Resonance Imaging, Cerebral Hemorrhage
Abstract

Intracerebral hemorrhage (ICH) is still a devastating stroke, with high mortality. Arterial hypertension (AHT) is the most common cause of primary ICH, causing changes in the wall of small vessels, leading to its rupture. Recent studies have attempted to understand the basic mechanisms of tissue damage around the hematoma. These days there is a debate regarding biochemical changes in this area, usually recognized as edema. Detection with the gradient-echo T2 weighted MRI of old and silent microhemorrhages in a patient with ICH as a radiological expression of a microangiopathy of small vessel poses questions regarding its predictive value of risk of bleeding recurrence. The object of our review is to analyze the present data that explains the interaction between chronic hypertension and primary ICH.

Published
2003

17. Bronchial asthma induced by chick pea and lentil

Author

Santiago Quirce, M. D. Alonso, Belén de la Hoz, J. A. Compaired, E. Losada, J. M. Igea, and J. A. Martin

Subjects
Adult, Male, Allergy, Immunology, Bronchial Provocation Tests, chemistry.chemical_compound, Antigen, Food allergy, medicine, Humans, Immunology and Allergy, Asthma, Plants, Medicinal, Inhalation, business.industry, Respiratory disease, food and beverages, Fabaceae, medicine.disease, respiratory tract diseases, chemistry, business, Histamine, Type I hypersensitivity
Abstract

Martin JA, Compaired JA, dc la Hoz B, Quirce S, Alonso MD, Igca JM, Losada E. Bronchial asthma induced by chick pea and lentil. Allergic reactions to legumes through inhalation have rarely been described. We report the case of a 20-year-old man who experienced asthmatic attacks when exposed to the steam from cooking either chick pea or lentil. Type I hypersensitivity to the antigens in these legumes was demonstrated by means of immediate skin reactivity, histamine release tests, RAST and RAST inhibition. Specific bronchial challenges with the heated (75° for 30 min) extracts of chick pea and lentil elicited isolated immediate responses.

Published
1992
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18. Occupational asthma induced by aniseed

Author

F. Duce, A. Lezaun, M. D. Alonso, Carlos Colás, M.A. Domínguez, and J. Fraj

Subjects
Adult, Male, Pathology, medicine.medical_specialty, Allergy, Immunology, Occupational disease, medicine.disease_cause, Bronchial Provocation Tests, Allergen, Radioallergosorbent Test, immune system diseases, medicine, Immunology and Allergy, Humans, Spices, Asthma, Inhalation, medicine.diagnostic_test, business.industry, Dust, Intradermal Tests, medicine.disease, respiratory tract diseases, Occupational Diseases, Seeds, Methacholine, Bronchial challenge test, business, Occupational asthma, medicine.drug
Abstract

This report deals with clinical and immunologic studies in a butcher with work-related asthma. Both the positive methacholine inhalation test and the significant changes observed in PEFR measurements supported the diagnosis of asthma. The significant fall observed in PEFR measurements when the patient handled aniseed supported the diagnosis of occupational asthma. Skin prick tests carried out with 13 spices showed positive reactions only to aniseed extract. The patient had high levels of specific antianiseed IgE antibodies. The bronchial challenge test with an aniseed extract showed an immediate response without a late response. These findings suggest that the respiratory symptoms in our patient were induced by the inhalation of aniseed dust through an IgE-mediated immunologic mechanism of immediate hypersensitivity. This study established the diagnosis of occupational asthma from aniseed dust sensitization.

Published
1996

20. Delayed allergic reaction to cefonicid

Author

J A, Martin, M D, Alonso, M, Lázaro, F, Parra, J A, Compaired, and E, Alvarez-Cuesta

Subjects
Drug Hypersensitivity, Time Factors, Cefonicid, Humans, Female, Hypersensitivity, Delayed, Middle Aged, Injections, Intramuscular, Skin Tests
Abstract

We report a case of delayed cutaneous reaction to intramuscular treatment with cefonicid, a second generation cephalosporin. An isolated late skin test response was observed to cefonicid only and not to other beta-lactams. A patch test with cefonicid 1% was positive after 48 and 96 hours.

Published
1994

21. Asthma and contact urticaria caused by rice in a housewife

Author

J. A. Martin, F. M. Parra, A. Lezaun, M. S. Cano, M. D. Alonso, Manuela Cuevas, J. M. Igea, and Santiago Quirce

Subjects
Adult, Hypersensitivity, Immediate, Veterinary medicine, Allergy, Rhinitis, Allergic, Perennial, Urticaria, Immunology, Immunoglobulin E, Histamine Release, Bronchial Provocation Tests, Contact urticaria, chemistry.chemical_compound, immune system diseases, medicine, Immunology and Allergy, Humans, Asthma, Conjunctivitis, Allergic, Skin Tests, medicine.diagnostic_test, biology, business.industry, food and beverages, Oryza, medicine.disease, respiratory tract diseases, chemistry, biology.protein, Methacholine, Bronchial challenge test, Female, business, Histamine, medicine.drug
Abstract

We report the case of an atopic housewife who presented with rhinoconjunctivitis-asthma and contact urticaria from handling rice and other cereals. She tolerated cooked cereals. Both skin prick tests with a rice extract (20% w/v) and a rub test with raw rice gave positive results. Bronchial challenge test with methacholine revealed a PC20 of 0.45 mg/ml. The challenge test with raw rice resulted in immediate and late clinical and spirometric responses; pretreatment with DSCG inhibited both responses. The histamine release test (HRT) with rice was positive, and we detected rice-specific IgE antibodies by REIA in the patient's serum. Skin prick tests, HRT, and RAST with a battery of cereals gave positive results. Finally, the rice REIA was inhibited by rice (75%), rye (63%), corn (64%), and wheat (51%) extracts.

Published
1994

22. Evaluation of basophil activation in mastocytosis with Hymenoptera venom anaphylaxis

Author

González-de-Olano, D., primary, Álvarez-Twose, I., additional, Morgado, J. M., additional, López, M. I. Esteban, additional, Castro, A. Vega, additional, Díaz de Durana, M. D. Alonso, additional, Sánchez-Muñoz, L., additional, Matito, A., additional, de la Hoz Caballer, B., additional, Sanz, M. L., additional, Orfao, A., additional, and Escribano, L., additional

Published
2010
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23. Pistachio nut hypersensitivity: identification of pistachio nut allergens

Author

E. Losada, A. Lezaun, A. M. Beristain, Manuela Cuevas, F. M. Parra, and M. D. Alonso

Subjects
Male, Allergy, Dried fruit, Urticaria, Immunology, Cross Reactions, medicine.disease_cause, Histamine Release, Trees, Allergen, Species Specificity, medicine, Immunology and Allergy, Humans, Nuts, Anacardiaceae, Food science, Cashew nut, Angioedema, Plant Proteins, Skin Tests, biology, business.industry, Plant Extracts, digestive, oral, and skin physiology, food and beverages, Allergens, Immunoglobulin E, Middle Aged, biology.organism_classification, medicine.disease, Lolium, Female, Pistachio Nuts, business, Food Hypersensitivity, Type I hypersensitivity
Abstract

Summary Type I hypersensitivity to pistachio nut antigens was demonstrated in three patients by means of immediate skin-test reuctivily. specific IgF determination by a lluoro-immunoassay (CAP). CAP-inhibition and leucocyte histamine release. Sensitization to other dried fruils and pollens was observed in the patients. The CAP-inhibition studies revealed signilicLint crossreactivity between pistachio and cashew nut belonging to the Anacardiaceae family, and between pistachio nut and other dried fruits belonging to taxonomically unrelated botanical families. No relevant crossallergenicity was observed between pistachio nut and Lolium and Olca pollens. Sodium dodecyi sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) of a pistachio nut extract followed by immunoblotting analysis identified four IgE-binding bands with molecular weights of 34. 41. 52 and 60 kD.

Published
1993

24. [Seronegative systemic lupus erythematosus and autoimmune thyroiditis]

Author

M A, González-Gay, M J, Cereijo, J J, Agüero, M D, Alonso, J L, Fernández Sueiro, and J I, Vidal

Subjects
Adult, Thyroiditis, Humans, Lupus Erythematosus, Systemic, Female, Autoimmune Diseases
Abstract

The association of systemic lupus erythematosus (SLE) and autoimmune thyroiditis has been previously described. We report a woman with negative antinuclear antibodies (ANA) and criteria for the diagnosis of SLE. The patient was also diagnosed with autoimmune thyroiditis. We review the clinical characteristics and the association of both entities. We also remark in this case the association of autoimmune thyroiditis with seronegative SLE.

Published
1993

25. Bronchial asthma caused by two unrelated vegetables

Author

F M, Parra, M, Lázaro, M, Cuevas, M C, Ferrando, J A, Martin, A, Lezaun, M D, Alonso, and M, Sanchez-Cano

Subjects
Plants, Medicinal, Fabaceae, Peak Expiratory Flow Rate, Immunoglobulin E, Middle Aged, Histamine Release, Antibodies, Asthma, Bronchial Provocation Tests, Forced Expiratory Volume, Vegetables, Leukocytes, Humans, Female, Food Hypersensitivity, Methacholine Chloride, Skin Tests
Abstract

Vegetable-induced asthma is an uncommon hazard. We report an atopic housewife, in whom rhinoconjunctivitis and acute asthma were associated with two vegetables of taxonomically unrelated botanical families (Swiss chard/Chenopodiaceae family and green beans/legume family). Type I hypersensitivity to the antigens in Swiss chard and green beans was demonstrated by means of skin tests, histamine release test, and specific IgE determination by RAST. Bronchial responses after specific bronchial challenges indicated that Swiss chard and green beans might be the causative factor for the acute asthma.

Published
1993

26. [Common variable immunodeficiency and polyarthritis: a case report]

Author

M A, González-Gay, M J, Cereijo, M D, Alonso, M, Bal, J J, Aguero, and J C, Corredoira

Subjects
Adult, Male, Common Variable Immunodeficiency, Knee Joint, Arthritis, Chronic Disease, Indomethacin, Remission Induction, Humans
Abstract

We describe a man with common variable immunodeficiency and polyarthritis. He had suffered several infections, including septic arthritis. For this reason we commenced treatment with antibiotics without obtaining a good response. Three weeks' later, and after knowing that the results of all the cultures were negative, we discontinued the antibiotic therapy and started treatment with indomethacin. A dramatic response was rapidly observed. We feel that an arthritis in a patient with a history of previous infections should alert us to the diagnostic possibility of primary antibody deficiency.

Published
1993

28. [Comparative study of von Willebrand factor in patients with temporal arteritis]

Author

M A, González-Gay, M D, Alvarez, A J, Machín, M D, Alonso, J, García González, M J, Cereijo, and M, Bal

Subjects
Polymyalgia Rheumatica, Biopsy, Giant Cell Arteritis, von Willebrand Factor, Humans
Abstract

Giant cell arteritis, temporal arteritis (TA), is a vasculitis which affects large and medium-sized vessels. The von Willebrand factor (vWF) is synthesized by endothelial cells and megakaryocytes. Increased amounts of vWF are released into plasma in response to an endothelial damage. vWF levels were studied by Electro-Immunodiffusion in 16 patients with TA (8 of them with a positive biopsy) and their values were compared with 5 patients with Polymyalgia Rheumatica (PMR) and 32 controls. We found higher amount of vWF in global TA, biopsy-positive TA, biopsy-negative TA, and PMR than in controls. There were no relationship between vWF amounts in plasma and clinical findings nor the laboratory parameters. We feel that although in our study vWF might be of some help as an alternative to the biopsy in those patients with high suspicion of TA, the results of other authors raise doubt about the usefulness of the determination of vWF in TA.

Published
1992

29. Hypersensitivity to trimethoprim

Author

M. D. Alonso, C. Marcos, B. De La Hoz, M. L. Diez, J. A. Martin, Ignacio Dávila, and F. M. Parra

Subjects
Adult, Urticaria, Immunology, urologic and male genital diseases, Immunoglobulin E, Trimethoprim, Oral administration, Trimethoprim-Sulfamethoxazole Combination, Trimethoprim, Sulfamethoxazole Drug Combination, medicine, Immunology and Allergy, Humans, heterocyclic compounds, Respiratory Tract Infections, biology, business.industry, Sulfamethoxazole, bacterial infections and mycoses, medicine.disease, female genital diseases and pregnancy complications, biology.protein, Urticaria pigmentosa, Female, Drug Eruptions, business, human activities, medicine.drug, Type I hypersensitivity
Abstract

We present two patients who experienced life-threatening immediate reactions and one patient who developed generalized urticaria following oral administration of trimethoprim (TMP) and sulfamethoxazole (SMX) combination. Skin prick tests with TMP were positive in the three patients. No patients reacted to skin prick tests with SMX. No significant levels of IgE antibodies to TMP were found by RAST in the serum of the patients. Normal subjects used as controls did not react to any of these tests. Single-blind, placebo-controlled oral challenges were positive with TMP and negative with SMX in all patients. These results suggest that the three patients developed type I hypersensitivity reactions to TMP. In our patients skin prick tests with TMP were useful in TMP hypersensitivity diagnosis.

Published
1992

30. [Polyarteritis nodosa in a woman with temporal arteritis]

Author

M D, Alonso, M A, González-Gay, B, Urraca, M, Bal, J, Guerrero, and J R, Pulpeiro

Subjects
Giant Cell Arteritis, Humans, Female, Aged, Polyarteritis Nodosa
Abstract

A case of a 74-year-old woman, with a histological diagnosis of Transient Arteritis two years before and Nodose Polyarteritis, is described. Although the coexistance of these two vasculitis in a same patient has been rarely described in the literature, we considered that the diagnostic suscpiction of Nodose Polyarteritis should be maintained in a patient with Transient Arteritis developing multisystemic signs.

Published
1992

31. Temporal arteritis in a northwestern area of Spain: study of 57 biopsy proven patients

Author

M A, González-Gay, M D, Alonso, J J, Agüero, M, Bal, B, Fernández-Camblor, and A, Sánchez-Andrade

Subjects
Male, Spain, Biopsy, Incidence, Giant Cell Arteritis, Humans, Female, Middle Aged, Aged, Temporal Arteries
Abstract

Fifty-seven patients, diagnosed with temporal arteritis by biopsy from 1981 to 1990, were studied. The average annual incidence rate/100,000 population aged 50 and older, which was slightly lower than those from other Mediterranean countries of Europe, was 6. Apart from a predominance of males, age, clinical and laboratory features were similar to those reported from other parts of the world. All patients received corticosteroid therapy, the majority of them recovered completely. Fifty-four were followed; 34 had already finished treatment (mean: 22 months, range: 12-50). Relapses occurred more commonly after 12 months of therapy, when the amount of prednisone given was low or discontinued.

Published
1992

33. Anaphylaxis during negative penicillin skin prick testing confirmed by elevated serum tryptase

Author

E. Esteban, M. A. Tejedor, Montserrat Fernandez-Rivas, M. Cuevas, M. D. Alonso Díaz de Durana, and M. L. Casas

Subjects
Adult, medicine.medical_specialty, Immunology, Tryptase, Penicillin allergy, Penicillins, Unconsciousness, Drug Hypersensitivity, Elevated serum, Antibody Specificity, Humans, Immunology and Allergy, Medicine, Anaphylaxis, Skin Tests, biology, business.industry, Pruritus, Serine Endopeptidases, Immunoglobulin E, medicine.disease, Dermatology, Penicillin, biology.protein, Female, Tryptases, Hypotension, business, Biomarkers, medicine.drug
Published
2003
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34. Occupational protein contact dermatitis from lettuce

Author

Apolinar Lezaun, M. D. Alonso, L. Conde Salazar, Manuela Cuevas, José Antonio Martín, E. Losada, M. D. Gumaraens, and F. Parra

Subjects
Adult, Allergy, business.industry, Cross sensitivity, Dermatology, medicine.disease, Plant Proteins, Dietary, Dermatitis, Occupational, Dermatitis, Allergic Contact, Immunology, medicine, Humans, Immunology and Allergy, Female, business, Contact dermatitis, Protein contact dermatitis
Published
1993
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35. Fixed eruption caused by ciprofloxacin with cross-sensitivity to norfloxacin

Author

M D, Alonso, J A, Martín, S, Quirce, I, Dávila, A, Lezaun, and M, Sanchez Cano

Subjects
Ciprofloxacin, Immunology, Humans, Immunology and Allergy, Drug Interactions, Female, Drug Eruptions, Aged, Norfloxacin, Skin Tests
Abstract

A case of fixed eruption caused by ciprofloxacin is reported. To our knowledge, no other cases have been published. Cross-sensitivity with another fluoroquinolone has been demonstrated.

Published
1993
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36. Serum sickness-like syndrome associated with cefaclor therapy

Author

A. Lezaun, F. M. Parra, M. D. Alonso, J. M. Igea, T. Sainz, and J. A. Martin

Subjects
Male, medicine.medical_specialty, medicine.drug_class, business.industry, Immunology, Cephalosporin, Infant, Syndrome, medicine.disease, Complement (complexity), Otitis Media, Serum Sickness, Drug adverse reaction, Child, Preschool, Serum sickness, medicine, Humans, Immunology and Allergy, Cefaclor, Intensive care medicine, business, Respiratory Tract Infections, Paediatric patients, medicine.drug
Abstract

We describe 2 cases of paediatric patients who developed the main clinical features of a serum sickness reaction, while on treatment with cefaclor. A decrease in complement values was observed in both cases. Physicians should be aware of the possibility of such drug adverse reaction.

Published
1992
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37. Thermophysical Properties of Meat Products: General Bibliography and Experimental Values

Author

Rodolfo Horacio Mascheroni, M. D. Alonso, and Pedro D. Sanz

Subjects
Work (thermodynamics), Thermal conductivity, Chemistry, Enthalpy, Bibliography, Thermodynamics, Experimental data, Atmospheric temperature range, Thermal diffusivity, Agricultural and Biological Sciences (miscellaneous), Heat capacity
Abstract

Experimental values for thermophysical properties of different kinds of meats are here presented such as: thermal conductivity, enthalpy, heat capacity, thermal diffusivity and density. All these values were obtained from an extensive selection of the existent bibliography. They correspond to measurements made at the normal temperature range during cooling and freezing processes. In the present work a complete and detailed table of bibliography is presented in order to facilitate the attainment of information about experimental data, measurement techniques and mathematical equations.

Published
1987
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38. [Case of multiple endocrine neoplasia type II-b]

Author

F, Alcacer García, M D, Alonso Salvador, J, Ballester Belenguer, J, Bort Martí, J, Ruiz Castillo, C, Carbonell Antolí, and J, García Conde-Bru

Subjects
Adult, Neurofibroma, Carcinoma, Multiple Endocrine Neoplasia, Adrenal Gland Neoplasms, Humans, Female, Pheochromocytoma, Thyroid Neoplasms
Published
1982

39. [Descriptive epidemiologic study of congenital abnormalities of the central nervous system in Spain (1976-1982)]

Author

M L, Martínez Frías, J, Salvador, A, Taramona, M D, Alonso, and L, Prieto

Subjects
Male, Anencephaly, Infant, Newborn, Gestational Age, Spina Bifida Occulta, Spain, Space-Time Clustering, Microcephaly, Birth Weight, Humans, Female, Encephalocele, Hydrocephalus, Maternal Age, Retrospective Studies
Abstract

Authors present an epidemiologic study of the five most frequent congenital birth defects of the central nervous system: anencephaly, spina bifida, encephalocele, hydrocephaly and microcephaly. Over a total of 409 liveborns with some of these anomalies, gathered from 1976 to 1982 in 46 maternities spread all over Spanish geography, they analyze its prevalence at birth, temporary and geographical distribution, sex ratio, gestational age, birth weight and maternal age. To analyze some of these variables they have separated different types of anomalies in three groups depending if they were present as an only defect (isolated), together with other defects in a not syndromic picture (associated), and forming part of a described syndrome (syndromes). This separation is an intention of forming homogeneous ethiopathogenic groups upon which epidemiologic methodology can be applied with assurance to interpret results in a right way.

Published
1984

40. Evaluation of basophil activation in mastocytosis with Hymenoptera venom anaphylaxis.

Author

González-de-Olano D, Alvarez-Twose I, Morgado JM, Esteban López MI, Vega Castro A, Díaz de Durana MD, Sánchez-Muñoz L, Matito A, de la Hoz Caballer B, Sanz ML, Orfao A, and Escribano L

Subjects
Adult, Aged, Anaphylaxis diagnosis, Animals, Female, Humans, Immunoglobulin E immunology, Male, Mastocytosis, Systemic immunology, Middle Aged, Sensitivity and Specificity, Anaphylaxis immunology, Arthropod Venoms immunology, Basophil Degranulation Test, Basophils cytology, Basophils immunology, Hymenoptera, Mastocytosis, Systemic diagnosis
Abstract

Background: Basophil activation tests (BATs) have been demonstrated to be useful in detecting IgE-mediated sensitization by measuring basophil activation surface markers (CD63 and CD203c). Hymenoptera venom is one of the best known mediators-release trigger in patients with systemic mastocytosis (SM). The aim of this study was to investigate the use of BATs as an additional diagnostic tool in patients with mastocytosis suffering from hymenoptera venom anaphylaxis (HVA)., Methods: A total of 22 patients with history of HVA and SM, together with a group of 11 patients with HVA in whom SM was ruled out after a complete bone marrow study, were analyzed., Results: Among 11 SM patients who had specific serum IgE (sIgE) against hymenoptera venom and an evaluable BAT, a positive BAT was found in nine. Additionally, a positive BAT was detected in three of seven patients who had no sIgE. These three patients had low levels of total IgE compared with control population (mean of 20 vs. 78 IU/mL); one had discontinued immunotherapy after 5 years, when sIgE levels had turned negative, and, in the other two patients, BAT identified the culprit insect., Conclusions: BAT is a useful complementary diagnostic tool to sIgE in mastocytosis patients with HVA, and it may contribute to predict or confirm these nearly fatal reactions, especially before discontinuing venom immunotherapy in patients who are negative for skin tests or sIgE or display low total IgE levels; in such cases, it also provides evidence on the culprit insect prompting HVA., (Copyright © 2010 International Clinical Cytometry Society.)

Published
2011
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41. Long-term outcomes in patients with schizophrenia treated with risperidone long-acting injection or oral antipsychotics in Spain: results from the electronic Schizophrenia Treatment Adherence Registry (e-STAR).

Author

Olivares JM, Rodriguez-Morales A, Diels J, Povey M, Jacobs A, Zhao Z, Lam A, Villalobos Vega JC, Cuéllar JA, de Castro FJ, Quintero CM, Martíin JF, Domínguez P, Ojeda JL, Cortés SS, Cala FI, Marín CG, Castro LM, Duaso MA, Albarracín JR, Vergara GN, Benítez AF, Cleries FM, Pérez-Brian JM, Aragón AB, Navarro JC, Biedma JA, de Pedro RB, González JF, López ME, Moreno HD, López JA, Rodríguez EO, de Hoyos CM, Sacristán MP, Martín MD, Ballesteros EM, Rodríguez PA, Menéndez LF, Rivas RS, del Pino Cuadrado P, Lauffer JC, Solano JJ, Martínez JM, Solano FG, Rodríguez PG, Rodríguez JA, Cano TR, Fortacin MD, Lobeiras JM, Sampedro JM, Bravo AP, Pellicer AF, López MD, Liste JF, Fernández MR, Losada AC, Mendez RV, Romero SA, Blanco JJ, Bonaselt IT, Mahia MC, del Valle EF, Yañez PQ, Camarasa MG, Alonso JA, Mendez GF, Feliz FD, Lamela MA, Piñero MV, Alvarado PF, Gómez IL, Martín PF, Gómez JL, López AG, Jiménez AR, Nafs AE, Barquero NC, Ortiz RF, Noguera JL, Carrasco PR, Muñoz JM, Palma MM, Hortelano CM, Bonome LS, Sevilla JS, Juan JM, Ramos JM, Muñoz JL, Guisasola JE, Vazquez LS, Guerras FC, Nebot FJ, Fernández FJ, Nicolau AL, Subirats RC, Kidias MM, Navarro VF, García BF, del Rosal FM, de Vicente Muñoz T, Ballester JA, Lieb PM, Martel AD, Bea ER, Joaquim IG, Enjuanes FB, Piñol MB, Carbonell EF, Muñoz RM, Giribets CA, Sans LA, Blanco AS, Felipe MA, Muñoz PG, Villanueva AP, Arroyo MB, Borri RC, Fallada SM, Merola MC, Rodon EP, Palmes JR, Martínez EP, Catala JM, Coca AS, Ferrandiz FP, Paya EF, Caballero GI, Bonet AF, Figueras JF, Pagador PM, Garibo MM, Camo VP, Carrillo CS, Valero CP, Rebollo FJ, García Campayo J, Sala Ayma JM, Roig MM, de Uña Mateos MA, Bertolin RG, García AM, Mazo FJ, Velasco JL, Pérez LS, Casado CJ, Barba JJ, Diaz MC, Rubio JP, Mandoli AS, Herrero AU, Martínez AR, Serrano PS, Rodríguez EN, Montesinos JS, Macia JF, Mateos Marcos AM, Soto JV, Dumont MV, Pagan JP, Martínez VB, Santiuste de Pablos M, Delgado CE, Quiles MD, López FJ, Navarro PP, Torres AM, Ingles FJ, Arias-Camison JM, Manzano JC, Peña RV, Guitarte GP, Fontecilla HB, Romero JB, Gil RS, Lozano JM, Adanez LD, Zarranz Herrera-Oria I, Jiménez JP, Vaz FC, García OS, Anton CC, Casula RR, Hernandez MC, Escabias FT, Torresano JR, Pérez-Villamil AH, Estevez L, Figuero MA, Muñoz de Morales A, Calvin JL, Criado MD, Rodríguez VM, Ambrosolio EB, Madera PM, Alfaro GP, Vidal MM, Valtuille AG, Ruiz O, Cabornero GL, Echevarria Martínez de Bujo M, Mallen MJ, Puigros JS, Martorell AL, Forteza AC, Arrebola ER, Rodríguez de la Torre M, Saiz CG, Bardolet I Casas C, Linde ER, De Arce Cordon R, Molina EM, Carazo FJ, Romero JJ, Cano DV, Dorado MS, Velazquez SC, Sánchez AJ, Leon SO, Sánchez KP, Benitez MH, Zugarramurai AI, Contreras MA, De la Varga González M, Marín PB, Robina FG, García MS, Pérez FJ, Bros PC, Gómez AC, de Dios Molina Martín J, Perera JL, Averbach MC, Perera JL, Palancares EG, Gallego de Dios MT, Rojo CF, Iglesias SS, Merino MI, Mestre NP, Urdaniz AP, Sánchez JM, Seco RG, Muñoz JF, Agut MM, Lozano ML, Herguedas FM, Pena AT, García JV, Martínez AV, Sanz Granado OS, Fernández MA, Canseco JM, López PA, Martín MA, Barrio JA, Ubago JG, Bennassar MR, Díez JM, Fleta JL, Fortes FP, López CA, Medina O, Alvarez DF, Roca JM, Valladolid GR, Tavera JA, García-Castrillon Sales JA, Llordes IB, Melgarejo CA, Cañas de la Paz F, Callol VV, García MB, García JB, Leal FJ, Corrales EC, Iglesias ES, Gómez MA, Serrano GG, Chillarón EG, Aguado FJ, Castillo JJ, González AG, Vázquez JG, Peralvarez MB, Diaz MR, Mesa MY, Artiles FJ, Chao MA, Mesa MY, del Rosario Santana P, Escudero MA, Berenguer MM, Llacer JM, Berna JA, Ortiz JB, Pardell LT, Hernández-Alvarez de Sotomayor C, Méndez MR, Garate RC, Múgica BD, González MC, Domingo JP, Navarro CS, Vera GS, Cuquerella MA, Monzo JL, Boada PC, Pérez MF, Parrado EC, Sánchez JJ, and Fernández JC

Subjects
Administration, Oral, Adult, Antipsychotic Agents adverse effects, Benzodiazepines administration & dosage, Benzodiazepines adverse effects, Delayed-Action Preparations, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Injections, Intramuscular, Long-Term Care, Male, Middle Aged, Olanzapine, Patient Readmission statistics & numerical data, Prospective Studies, Psychiatric Status Rating Scales, Registries, Risperidone adverse effects, Antipsychotic Agents administration & dosage, Medication Adherence, Risperidone administration & dosage, Schizophrenia drug therapy, Schizophrenic Psychology
Abstract

Background: The electronic Schizophrenia Treatment Adherence Registry (e-STAR) is a prospective, observational study of patients with schizophrenia designed to evaluate long-term treatment outcomes in routine clinical practice., Methods: Parameters were assessed at baseline and at 3 month intervals for 2 years in patients initiated on risperidone long-acting injection (RLAI) (n=1345) or a new oral antipsychotic (AP) (n=277; 35.7% and 36.5% on risperidone and olanzapine, respectively) in Spain. Hospitalization prior to therapy was assessed by a retrospective chart review., Results: At 24 months, treatment retention (81.8% for RLAI versus 63.4% for oral APs, p<0.0001) and reduction in Clinical Global Impression Severity scores (-1.14 for RLAI versus -0.94 for APs, p=0.0165) were significantly higher with RLAI. Compared to the pre-switch period, RLAI patients had greater reductions in the number (reduction of 0.37 stays per patient versus 0.2, p<0.05) and days (18.74 versus 13.02, p<0.01) of hospitalizations at 24 months than oral AP patients., Conclusions: This 2 year, prospective, observational study showed that, compared to oral antipsychotics, RLAI was associated with better treatment retention, greater improvement in clinical symptoms and functioning, and greater reduction in hospital stays and days in hospital in patients with schizophrenia. Improved treatment adherence, increased efficacy and reduced hospitalization with RLAI offer the opportunity of substantial therapeutic improvement in schizophrenia.

Published
2009
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