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1. Six-Month Synbio® Administration Affects Nutritional and Inflammatory Parameters of Older Adults Included in the PROBIOSENIOR Project

Author

Chiara Salvesi, Stefania Silvi, Dennis Fiorini, Laura Alessandroni, Gianni Sagratini, Francesco Alessandro Palermo, Renato De Leone, Nadaniela Egidi, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura, Amedeo Amedei, Elena Niccolai, Francesca Scocchera, Fausto Mannucci, Valerio Valeriani, Marco Malavasi, Sara Servili, Andrea Casula, Andrea Cresci, Ivano Corradetti, Maria Magdalena Coman, and M. Cristina Verdenelli

Subjects
probiotics, malnutrition, inflammation, elderly, Biology (General), QH301-705.5
Abstract

The physiological changes associated with ageing contribute to the incidence of diseases, morbidity, and mortality. For modern society, it is essential to find solutions to improve elderly people’s health and quality of life. Among promising strategies, the PROBIOSENIOR project proposed a daily six-month supplementation with new probiotic functional foods and nutraceuticals. The aim of this work was to evaluate the modulating effects of the probiotic diet on inflammatory markers and nutritional status. Ninety-seven elderly volunteers were randomly assigned to either a placebo-diet group or a probiotic-diet group (SYNBIO®). Faeces, urine, and blood samples were collected before and after the supplementation to determine serum cytokines, biogenic amines, and inflammation markers. Comparing the results obtained before and after the intervention, probiotic supplementations significantly decreased the TNF-α circulating levels and significantly increased those of IGF-1. Biogenic-amine levels showed high variability, with significant variation only for histamine that decreased after the probiotic supplementation. The supplementation influenced the serum concentration of some crucial cytokines (IL-6, IL-8, and MIP-1α) that significantly decreased in the probiotic group. In addition, the Mini Nutritional Assessment questionnaire revealed that the probiotic-supplemented group had a significant improvement in nutritional status. In conclusion, the PROBIOSENIOR project demonstrated how SYNBIO® supplementation may positively influence some nutritional and inflammatory parameters in the elderly.

Published
2023
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2. Probiotic-enriched foods and dietary supplement containing SYNBIO positively affects bowel habits in healthy adults: an assessment using standard statistical analysis and Support Vector Machines

Author

Stefania Silvi, Renato De Leone, Maria Magdalena Coman, Cinzia Cecchini, Alberto Cresci, Jessica Rosati, M Cristina Verdenelli, M. Simonetta Bernabei, and Carla Orpianesi

Subjects
Adult, Male, medicine.medical_specialty, Support Vector Machine, Enriched Food, Bowel habit, law.invention, Feces, Habits, Probiotic, Double-Blind Method, Quality of life, Reference Values, law, Rating scale, Internal medicine, medicine, Humans, Food science, Defecation, Gastrointestinal tract, Bacteria, Lacticaseibacillus rhamnosus, business.industry, Probiotics, Intestines, Lactobacillus, Health, Food, Fortified, Cohort, Food Microbiology, Quality of Life, Female, business, Constipation, Food Science
Abstract

A randomised, double-blind, placebo-controlled, parallel group study assessed in healthy adults how daily consumption of the probiotic combination SYNBIO®, administered in probiotic-enriched foods or in a dietary supplement, affected bowel habits. Primary and secondary outcomes gave the overall assessment of bowel well-being, while a Psychological General Well-Being Index compiled by participants estimated the health-related quality of life as well as the gastrointestinal tolerance determined with the Gastrointestinal Symptom Rating Scale. Support Vector Machine models for classification problems were used to validate the total outcomes on bowel well-being. SYNBIO® consumption improved bowel habits of volunteers consuming the probiotic foods or capsules, while the same effects were not registered in the control groups. The recovery of probiotic bacteria from the faeces of a cohort of 100 subjects for each supplemented group showed the persistence of strains in the gastrointestinal tract.

Published
2014

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