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Abstract The mechanisms of romantic bonding in humans are largely unknown. Recent research suggests that physiological synchrony between partners is associated with bonding. This study combines an experimental approach with a naturalistic dating setup to test whether the individual differences in social and nonsocial synchrony are interdependent, and linked to romantic attractiveness. In a preregistered online experiment with 144 participants, we discover that inducing physiological synchrony between an actor and an actress determines their attractiveness ratings by participants, indicating that synchrony can increase perceived attraction. In a lab-based naturalistic speed-dating experiment, we quantify in 48 participants the individual tendency for social physiological synchrony, nonsocial sensorimotor synchrony, and romantic attractiveness. We discover that the individual propensity to synchronize in social and nonsocial tasks is correlated. Some individuals synchronize better regardless of partners or tasks, and such Super Synchronizers are rated as more attractive. Altogether, this demonstrates that humans prefer romantic partners who can synchronize.

One of the greatest threats to groundwater is contamination from fuel derivatives. Benzene, a highly mobile and toxic fuel derivative, can easily reach groundwater from fuel sources and lead to extensive groundwater contamination and drinking water disqualification. Modelling benzene transport in the unsaturated zone can quantify the risk for groundwater contamination and provide needed remediation strategies. Yet, characterization of the problem is often complicated, due to typical soil heterogeneity, numerous unknown site and solute parameters, and the difficulty of distinguishing important from non-important parameters. Thus, sensitivity analysis (SA) methods, such as global SA (GSA), are applied to reduce uncertainty and detect key parameters for groundwater contamination and remediation. Nevertheless, studies devoted to identifying the parameters that determine transport of fuel derivatives in the unsaturated zone are scarce. In this study, we performed GSA to assess benzene transport in the unsaturated zone. First, a simple GSA (Morris) screening method was used for a homogenous sandy vadose zone. Then, a more computationally demanding (Sobol) variance-based GSA was run on the most influential parameters. Finally, the Morris method was tested for a heterogeneous medium containing clay layers. To overcome model crashes during GSA, several methods were tested for imputation of missing data. The GSA results indicate that benzene degradation rate (λk) is the utmost influential parameter controlling benzene mobility, followed by aquifer depth (z). The adsorption coefficient (Kd) and the van Genuchten n parameter of the sandy soil (n1) were also highly influential. The study emphasizes the significance of λk and the presence of clay layers in predicting aquifer contamination. The study also indicates the importance of heterogenous media representation in the GSA. Though identical parameters control the transport in the different soil types, in the presence of both sand and clay, parameters directly affecting the solute concentration like λk and Kd have increased influence in clay, whereas n is more influential for sand comprising most of the profile. Overall, GSA is demonstrated here as an important tool for the analysis of transport models. The results also show that in higher dimensionality models, the radial basis function (RBF) is an efficient surrogate model for missing data imputation.

Abstract Terrestrial Gamma‐ray Flashes (TGFs) are ten‐to‐hundreds of microsecond bursts of gamma‐rays produced when electrons in strong electric fields in thunderclouds are accelerated to relativistic energies. Space instruments have observed TGFs with source photon brightness down to ∼1017–1016. Based on space and aircraft observations, TGFs have been considered rare phenomena produced in association with very few lightning discharges. Space observations associated with lightning ground observations in the radio band have indicated that there exists a population of dimmer TGFs. Here we show observations of TGFs from aircraft altitude that were not detected by a space instrument viewing the same area. The TGFs were found through Monte Carlo modeling to be associated with 1015–1012 photons at source, which is several orders of magnitude below what can be seen from space. Our results suggest that there exists a significant population of TGFs that are too weak to be observed from space.

The SO2 emission rates from three power plants in North Carolina are estimated using the HYSPLIT Lagrangian dispersion model and aircraft measurements made on 26 March 2019. To quantify the underlying modeling uncertainties in the plume rise calculation, dispersion simulations are carried out in an ensemble using a total of 15 heat release parameters. For each heat release, the SO2 emission rates are estimated using a transfer coefficient matrix (TCM) approach and compared with the Continuous Emissions Monitoring Systems (CEMS) data. An “optimal” member is first selected based on the correlation coefficient calculated for each of the six segments that delineate the plumes from the three power plants during the morning and afternoon flights. The segment influenced by the afternoon operations of Belews Creek power plant has negative correlation coefficients for all the plume rise options and is first excluded from the emission estimate here. Overestimations are found for all the segments before considering the background SO2 mixing ratios. Both constant background mixing ratios and several segment-specific background values are tested in the HYSPLIT inverse modeling. The estimation results by assuming the 25th percentile observed SO2 mixing ratios inside each of the five segments agree well with the CEMS data, with relative errors of 18 %, −12 %, 3 %, 93.5 %, and −4 %. After emission estimations are performed for all the plume rise runs, the lowest root mean square errors (RMSEs) between the predicted and observed mixing ratios are calculated to select a different set of optimal plume rise runs which have the lowest RMSEs. Identical plume rise runs are chosen as the optimal members for Roxboro and Belews Creek morning segments, but different members for the other segments yield smaller RMSEs than the previous correlation-based optimal members. It is also no longer necessary to exclude the Belews Creek afternoon segment that has a negative correlation between predictions and observations. The RMSE-based optimal runs result in much better agreement with the CEMS data for the previously severely overestimated segment and do not deteriorate much for the other segments, with relative errors of 18 %, −18 %, 3 %, −9 %, and 27 % for the five segments and 2 % for the Belews Creek afternoon segment. In addition, the RMSE-based optimal heat emissions appear to be more reasonable than the correlation-based values when they are significantly different for CPI Roxboro power plant.

Physical activity has been shown to have many benefits, including reducing cancer-related fatigue (CRF) and improving psychological and physical recovery from breast cancer. Some authors have shown the benefits of aquatic practice, while others have detailed the benefits of group and supervised practice. We hypothesize that an innovative sports coaching proposal could allow a significant adherence of patients and contribute to their health improvement. The main objective is to study the feasibility of an adapted water polo programme (aqua polo) for women after breast cancer. Secondarily we will analyse the effect of such a practice on patients' recovery and study the relationship between coaches and participants. The use of mixed methods will allow us to question the underlying processes precisely. This is a prospective, non-randomized, monocentric study with a sample of 24 breast cancer patients after treatment. The intervention is a 20 week programme (1 session per week) of aqua polo in a swim club facility, supervised by professional water-polo coaches. The variables measured are patient participation, quality of life (QLQ BR23), CRF (R–PFS) and post-traumatic growth (PTG-I) as well as different variables to observe physical capacity (strength with dynamometer, step-test and arm amplitude). The quality of the coach-patient relationship will be evaluated (CART-Q) to explore its dynamics. Participatory observations and interviews will be carried out to report on the interactions between the coach and the participants during the sessions. Registration number and name of trial registry: No. EudraCT or ID-RCB: 2019-A03003-54 and NCT: NCT04235946

Sixty days after the lockdown of Hubei Province, where the coronavirus was first reported, China's true recovery from the pandemic remained an outstanding question. This study investigates how human activity changed during this period using observations of surface pollutants. By combining surface data with a three-dimensional chemistry model, the impacts of meteorological variations and variations in yearly emission control are minimized, demonstrating how pollutant levels over China changed before and after the Lunar New Year from 2017 to 2020. The results show that the reduction in NO2 concentrations, an indicator of emissions in the transportation sector, was clearly greater and longer in 2020 than in normal years and started to recover after 15 February. By contrast, PM2.5 emissions had not yet recovered by the end of March, showing a reduction of around 30 % compared with normal years. SO2 emissions were not affected significantly by the pandemic. An additional model study using a top–down emission adjustment still confirms a reduction of around 25 % in unknown surface PM2.5 emissions over the same period, even after realistically updating SO2 and NOx emissions. This evidence suggests that different economic sectors in China may be recovering at different rates, with the fastest recovery in transportation and a slower recovery likely in agriculture. The apparent difference between the recovery timelines of NO2 and PM2.5 implies that monitoring a single pollutant alone (e.g., NOx emissions) is insufficient to draw conclusions on the overall recovery of the Chinese economy.

Abstract Background Few studies of robotic nipple sparing mastectomy (NSM) were reported. We report feasibility of robotic NSM and determine standard surgical procedure and learning curve threefold. Methods A cohort of patients with robotic NSM for breast cancer was analyzed. Complications and post-operative hospitalization stay were reported. The same technic was used for all patients except for skin and nipple areolar complex (NAC) dissection. Differences between three surgical procedures of NAC dissection were analyzed: group 1, dissection with robotic scissors using coagulation; group 2, dissection with robotic scissors without coagulation; and group 3, dissection with non-robotic scissors and then robotic dissection. We explored possible effect of learning curve among patients from group 1 with the same surgical procedure. Results Twenty-seven NSM with immediate breast reconstruction for breast cancers, 22 invasive and 5 in situ, were performed, with robotic latissimus dorsi-flap (RLDF) only in 17 cases, RLDF and breast implant in 6 cases, and implant alone in 4 cases. Repartition according to 3 surgical procedure groups was 16, 5, and 6 patients. Mean time of surgery and anesthesia decrease according to groups 1 to 3. Among 16 patients from group 1, time of surgery and anesthesia decreased with learning curve. Post-operative hospitalization decreased from group 1 to 3. We reported a total of 11 complications, with significant difference between groups (10 for group 1). Skin complications were higher for group 1 in comparison with groups 2–3 (p = 0.02). Conclusion Robotic NSM can be performed with a brief learning. Standardized technique is proposed with non-robotic scissors superficial dissection and then dissection with robot.

Objectives: Proctitis caused by Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) are known as sexually transmitted infections (STI). This study describes their clinical, diagnostic and therapeutic aspects. Methods: Between 01/2013-03/2015, all MSM consulting for proctitis at proctology Institute-Saint-Joseph’s Hospital, Paris, were included. Demographic, past-medical history, STI status and medical treatment were collected. Detection of CT/NG was performed by Transcription-Mediated Amplification (TMA) and antimicrobial susceptibilities for Ng by agar diffusion method. Results: On 441 rectal samples collected, 221 (50.1%) were positive: 109 Ct (49.3%), 70 Ng (31.7%), 42 positive for both etiologies (19%). Among Ng infections, no resistance was detected to azithromycin and ceftriaxone. However, 84 strains (43.2%) were resistant to fluoroquinolones. More than one episode was diagnosed for 10 (5.1%) and 12 (6.2%) patients with CT and NG infections respectively. Anal abscesses were found for 27 (13.9%) patients, and 14 (7.2%) of them underwent surgery for anal fistula. Conclusions: The prevalence of CT/NG anorectal infections described is high on symptomatic patients, and a significant level of abscess was reported. These results confirm the interest of the association of recommended antibiotics excluding quinolones. Prospective studies would be relevant on complicated forms of anorectal infections.

The Learning Forward Academy is Learning Forward's flagship deep learning experience, committed to increasing educator and leader capacity and improving results for students in the ever-changing landscape of education. For over 30 years, the academy has supported the problem-based learning of teachers, teacher leaders, instructional coaches, principals, regional leaders, superintendents, and others whose jobs involve supporting the learning of other adults and students. The academy brings together educator leaders with expert coaches to create successful and sustainable change in their educational systems. Over the professional learning program's 2 and a half years, participants learn about and implement several system improvement tools, such as root cause analysis and theory of change, and work together on their individual problems of practice. At the core of the academy is an understanding that educational improvement is iterative and requires continuous assessment, adaptation, and refinement, as well as ongoing learning among all educators in a system. This article examines how a principal was able to use the lessons she learned at the academy to improve reading grade levels and combat chronic absenteeism at her school in New Jersey.

Staphylococcus spp meticillin resistant infection can be treated with Linezolid. This is a case report of an orthopaedic implant infection in a 60 year-old male treated orally with Linezolid and Rifampicin for three months after one-stage arthroplasty. This is possible provided that platelet count is closely monitored throughout the course of treatment.

We examined short- and long-term effects of high milking frequency (HMF) for the first 21 days of lactation. The study included 122 Israeli Holstein cows – 32 pregnant heifers, 40 cows in second lactation and 50 cows in >second lactation. Heifers were paired according to predicted transmitting ability and cows according to energy-corrected milk (ECM) production, age, days in milk and expected calving date. Thin cows (body condition score second lactation cows relative to their control counterparts (−0.37%); ECM production was also higher in 6× milking first and second lactation (7.6% and 5%, respectively) but not for >second lactation cows. Furthermore, HMF had long-lasting effects, expressed as significantly higher milk production through the succeeding lactation in the previous first lactation cows (10%); a tendency toward significance in the second lactation cows relative to the controls (4.7%), but a deleterious effect on the >second lactation cows, reflected by lower milk production (−5.25%) than in controls; similar patterns were found for the ECM. For the entire 305 days of lactation, fat and protein yields were higher for first and second lactation cows, whereas protein yield for >second lactation cows was lower in the 6× milking v. control group. Given that HMF during the first 21 days of first or second lactation increases milk and ECM yields throughout the concurrent and successive lactation with no adverse effect on energy balance, mastitis, metabolic diseases or reproduction, it seems to be economically beneficial. However, caution should be paid for >second lactation cows due to absence of significant effect in the entire of the first HMF applied lactation and the deleterious effect in the succeeding lactation.

Therapy for ST-segment elevation myocardial infarction patients who present late or are ineligible for reperfusion.

Hantaan virus (HTNV) and Puumala virus (PUUV) are pathogenic hantaviruses found in Asia and Europe, respectively. DNA vaccines targeting the envelope glycoproteins of these viruses have been constructed and found to elicit neutralizing antibodies when delivered to humans by various technologies including intramuscular electroporation. Here, we report findings from a Phase 2a clinical trial of a combined HTNV/PUUV DNA vaccine delivered at varying doses and administration schedules using the Ichor Medical Systems TriGrid intramuscular electroporation delivery technology. The study was designed to characterize the effects of DNA vaccine dose and number of administrations on the frequency and magnitude of immunological response. Subjects (n = 120) were divided into four cohorts. Cohorts 1 and 2 received a dose of 2 mg of DNA (1 mg per plasmid), and cohorts 3 and 4 received a dose of 1 mg of DNA (0.5 mg per plasmid) each vaccination. Each of the four cohorts received a series of four administrations (days 0, 28, 56 and 168). For cohorts 1 and 3, the DNA vaccine candidate was delivered at each of the four administrations. For cohorts 2 and 4, in order to maintain blinding, subjects received the DNA vaccine on days 0, 56 and 168, but on day 28 received only the phosphate buffered saline vehicle rather the DNA vaccine. Sera were collected on days 0, 28, 56, 84, 140, 168, 196, 252 and 365 and evaluated for the presence of neutralizing antibodies by PUUV and HTNV pseudovirion neutralization assays (PsVNAs). Day 84 was also evaluated by a plaque reduction neutralization test (PRNT). Overall the PsVNA50 geometric mean titers (GMTs) and seropositivity rates among cohorts were similar. Cohort 3 exhibited the highest frequency of subjects that became seropositive to both PUUV and HTNV after vaccination, the highest peak GMT against both viruses, and the highest median titers against both viruses.

The cause for severe, recurrent lower gastrointestinal (LGI) bleeding in children can usually be diagnosed readily by means of the commonly used investigative/diagnostic techniques such as colonoscopy, laparoscopy ± laparotomy. Occasionally less commonly used investigations may be necessary to look for more elusive causes of LGI bleeding such as capsule endoscopy, angiography, technetium-99m (99m Tc)-labeled red blood cell (RBC) scintigraphy, cross-sectional imaging such as CT/MRI (including angiography) and laparotomy combined with on-table small bowel enteroscopy. We report a case of severe, recurrent LGI bleeding that had occurred over several years, where the cause remained elusive despite numerous investigations and interventions. The etiology of this was eventually found to be a gastric duplication cyst infiltrating into adjacent transverse colon and causing bleeding from peptic ulceration in the colon. The process by which this diagnosis was made and the lessons learned are discussed.

UAVs equipped with high-resolution thermal cameras provide an excellent investigative tool used for a multitude of building-specific applications, including roof insulation inspection. We have presented in this study a relative thermographic calibration algorithm and a superpixel Markov Random Field model to address problems in thermal infrared inspection of roof insulation using UAVs. The relative thermographic radiometric calibration algorithm is designed to address the autogain problem of the thermal camera. Results show the algorithm can enhance the contrast between warm and cool areas on the roof surface in thermal images, and produces more constant thermal signatures of different roof insulations or surfaces, which could facilitate both visual interpretation and computer-based thermal anomaly detection. An automatic thermal anomaly detection algorithm based on superpixel Markov Random Field is proposed, which is more computationally efficient than pixel based MRF, and can potentially improve the production throughput capacity and increase the detection accuracy for thermal anomaly detection. Experimental results show the effectiveness of the proposed method.

Landscape influences fauna movement at different levels, from habitat selection to choices of movements’ direction. Our goal is to provide a development frame in order to test simulation functions for animal’s movement. We describe our approach for such simulations and we compare two types of functions to calculate trajectories. To do so, we first modelled the role of landscape elements to differentiate between elements that facilitate movements and the ones being hindrances. Different influences are identified depending on landscape elements and on animal species. Knowledge were gathered from ecologists, literature and observation datasets. Second, we analysed the description of animal movement recorded with GPS at fine scale, corresponding to high temporal frequency and good location accuracy. Analysing this type of data provides information on the relation between landscape features and movements. We implemented an agent-based simulation approach to calculate potential trajectories constrained by the spatial environment and individual’s behaviour. We tested two functions that consider space differently: one function takes into account the geometry and the types of landscape elements and one cost function sums up the spatial surroundings of an individual. Results highlight the fact that the cost function exaggerates the distances travelled by an individual and simplifies movement patterns. The geometry accurate function represents a good bottom-up approach for discovering interesting areas or obstacles for movements.

The individual and combined effects of global climate change and emissions changes from 2000 to 2050 on atmospheric mercury levels in the United States are investigated by using the global climate-chemistry model, CAM-Chem, coupled with a mercury chemistry-physics mechanism (CAM-Chem/Hg). Three future pathways from the Intergovernmental Panel on Climate Change (IPCC) Special Report on Emissions Scenarios (SRES) are considered, with the A1FI, A1B and B1 scenarios representing the upper, middle and lower bounds of potential climate warming, respectively. The anthropogenic and biomass burning emissions of mercury are projected from the energy use assumptions in the IPCC SRES report. Natural emissions from both land and ocean sources are projected by using dynamic schemes. TGM concentration increases are greater in the low latitudes than they are in the high latitudes, indicative of a larger meridional gradient than in the present day. In the A1FI scenario, TGM concentrations in 2050 are projected to increase by 2.1–4.0 ng m−3 for the eastern US and 1.4–3.0 ng m−3 for the western US. This spatial difference corresponds to potential increases in wet deposition of 10–14 μg m−2 for the eastern US and 2–4 μg m−2 for the western US. The increase in Hg(II) emissions tends to enhance wet deposition and hence increase the risk of higher mercury entering the hydrological cycle and ecosystem. In the B1 scenario, mercury concentrations in 2050 are similar to present level concentrations; this finding indicates that the domestic reduction in mercury emissions is essentially counteracted by the effects of climate warming and emissions increases in other regions. The sensitivity analyses show that changes in anthropogenic emissions contribute 32–53% of projected changes in mercury air concentration, while the independent contribution by climate change and its induced natural emissions change accounts for 47–68%.

The objective of the review was to identify and assess the quality of studies of the costs and benefits of different sentencing options. The review found only nine studies providing costs and benefits information. Due to the small number of studies uncovered by the review and, in some cases, poor methodologies, it has not been possible to draw firm conclusions from the individual studies in order to make comparisons between studies on the benefit‐cost of particular sentencing options. Tentative conclusions are drawn, where supporting evidence is available, and the authors recommend improved quality of research design and the development of standardized methodologies for assessing the costs and benefits of criminal justice interventions. Abstract Introduction Sentencing policies are most frequently designed by policy‐makers and implemented by the courts with the aim of punishing, deterring and rehabilitating offenders in order to reduce future re‐offending. However many sentencing decisions are made without knowledge of the effectiveness of sentences in achieving their objectives, or the costs and benefits of the different sentencing alternatives. The following systematic review was conducted in order to address these questions and to review the existing evidence on the costs and benefits of different sentencing options. Results from cost‐effectiveness studies were retained to provide supporting information. Objective The objective of the review was to identify and assess the quality of studies of the costs and benefits of different sentencing options. Search Strategy Pre‐screening and hand‐searching of published and available unpublished literature was completed by two independent reviewers. The structured searches were carried out on studies published between 1980‐2001, using nine electronic databases and by consulting experts in the field. Selection Criteria Studies were included in the review if they contained information on the costs and benefits of sentencing options. Due to the small number of benefit‐cost studies found, cost‐effectiveness study outcomes were also retained. Data collection and analysis Results from nine benefit‐cost studies and eleven cost‐effectiveness studies are reported in narrative and tabular form. Benefit‐cost ratios are presented alongside benefit‐cost outcome measures. The quality of studies is reported using the Maryland Scientific Scale (Sherman, Farrington, Welsh & Mackenzie, 2002) and a Benefit‐Cost Validity Scale ‐ Revised (Cohen & McDougall, 2008, Appendix 1). Main results The review found only nine studies providing costs and benefits information. Six of these studies were assessed as providing a ‘valid’ or ‘comprehensive’ benefit‐cost analysis, acceptable on the Benefit‐Cost Validity Scale – Revised, covering a range of different sentences. Two studies of In‐prison Sex Offender Treatment were found to be cost‐beneficial, in addition to an Intensive Supervision program and a Youth Wilderness Program, though the two latter interventions are less well‐supported by the wider research evidence. Diversion from imprisonment to drug treatment was assessed by its authors to be cost‐beneficial; and imprisonment for high risk offenders was considered to be cost‐beneficial, though not for less prolific offenders or for drug offenders. The three studies which provided only a ‘partial’ benefit‐cost analysis examined effectiveness of probation vs. prison, prisoners released early compared to those serving a full term, and house arrest with electronic monitoring. Reviewer's comments Due to the small number of studies uncovered by the review and, in some cases, poor methodologies, it has not been possible to draw firm conclusions from the individual studies in order to make comparisons between studies on the benefit‐cost of particular sentencing options. Tentative conclusions are drawn, where supporting evidence is available, and the authors recommend improved quality of research design and the development of standardized methodologies for assessing the costs and benefits of criminal justice interventions.

Antiphospholipid syndrome (APS) is an acquired thrombophilia with clinical manifestations associated with the presence of antiphospholipid antibodies (aPL) in patient plasma. Obstetrical APS is a complex entity that may affect both mother and fetus throughout the entire pregnancy with high morbidity. Clinical complications are as various as recurrent fetal losses, stillbirth, intrauterine growth restriction (IUGR), and preeclampsia. Pathogenesis of aPL targets trophoblastic cells directly, mainly via proapoptotic, proinflammatory mechanisms, and uncontrolled immunomodulatory responses. Actual first-line treatment is limited to low-dose aspirin (LDA) and low-molecular weight heparin (LMWH) and still failed in 30% of the cases. APS pregnancies should be a major field in obstetrical research, and new therapeutics are still in progress.

Une étude comparative France-Espagne des relations entre érosion, paysage et développement durable a associé des protocoles de mesure et de régionalisation de l’érosion et des enquêtes auprès des acteurs locaux. En Catalogne (matrice forestière), les chemins produisent beaucoup de sédiments ; dans les des Alpes du Sud (paysage en mosaïque), ce sont les roubines sur substrat marneux. Ces mesures sont confirmées par les premiers essais de généralisation ; une méthode automatique est proposée. Les enquêtes montrent une certaine sous-estimation du problème de l’érosion, la priorité étant la protection contre l’incendie en Catalogne et le contrôle de la progression forestière dans les Alpes du Sud.

Le boisement spontané des terres agricoles est abordé de façon interdisciplinaire, par les sciences de la nature et les sciences sociales. Selon l'échelle à laquelle le phénomène est appréhendé, différentes sources et méthodes de traitement de données sont mobilisées. La confrontation des données d'ordre naturaliste et socio-économique est opérée parallèlement par l'analyse multivariée et par le Système d'information géographique (SIG). Différentes hypothèses explicatives de l'avancée des ligneux sont ainsi testées et hiérarchisées.