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Abstract Synthesizing uniform and high concentrations of 3He within minerals via high‐energy proton irradiation is paramount for 4He/3He thermochronology and helium diffusion kinetic studies. Proton irradiations of geological material have hitherto exclusively been routinely conducted at the Francis H. Burr Proton Therapy Center (FHB); we thus explored alternative irradiation protocols at two European‐based facilities with the intention to improve the accessibility and efficiency in obtaining 4He/3He data. We conducted a single irradiation at the Paul Scherrer Institute (PSI) using an approach most similar to that used at FHB (wide, high‐energy beam), and four irradiations at the Helmholtz Zentrum Berlin (HZB) using a newly developed in‐vacuum irradiation protocol in a narrow, lower‐energy but high‐intensity beam. Internal shards of Durango apatite were irradiated in all experiments; 4He/3He release spectra and bulk 3He concentrations of PSI and HZB‐irradiated Durango shards were compared to those from FHB to assess the quality of each experiment in terms of the quantity and uniformity of synthesized 3He. While 3He was uniformly synthesized in PSI‐irradiated Durango shards, the bulk 3He concentration was below the required threshold due to limitations on the maximum allotted proton flux. Over the course of four irradiation experiments at HZB, the protocol evolved to ensure that uniform and high concentrations of 3He can be consistently induced. Furthermore, we demonstrate how HZB irradiations can be replicated using computer simulations, permitting the use of simulations to inform future modifications of the irradiation protocol in order to optimize the uniformity of the 3He distribution across all irradiated samples.

Abstract Much of our long-term knowledge is organised in complex networks. Sleep is thought to be critical for abstracting knowledge and enhancing important item memory for long-term retention. Thus, sleep should aid the development of memory for networks and the abstraction of their structure for efficient storage. However, this remains unknown because past sleep studies have focused on discrete items. Here we explored the impact of sleep (night-sleep/day-wake within-subject paradigm with 25 male participants) on memory for graph-networks where some items were important due to dense local connections (degree centrality) or, independently, important due to greater global connections (closeness/betweenness centrality). A network of 27 planets (nodes) sparsely interconnected by 36 teleporters (edges) was learned via discrete associations without explicit indication of any network structure. Despite equivalent exposure to all connections in the network, we found that memory for the links between items with high local connectivity or high global connectivity were better retained after sleep. These results highlight that sleep has the capacity for strengthening both global and local structure from the world and abstracting over multiple experiences to efficiently form internal networks of knowledge.

IntroductionObesity affects cardiac geometry, causing both eccentric (due to increased cardiac output) and concentric (due to insulin resistance) remodelling. Following bariatric surgery, reversal of both processes should occur. Furthermore, epicardial adipose tissue loss following bariatric surgery may reduce pericardial restraint, allowing further chamber expansion. We investigated these changes in a serial imaging study of adipose depots and cardiac geometry following bariatric surgery.Methods62 patients underwent cardiac magnetic resonance (CMR) before and after bariatric surgery, including 36 with short-term (median 212 days), 37 medium-term (median 428 days) and 32 long-term (median 1030 days) follow-up. CMR was used to assess cardiac geometry (left atrial volume (LAV) and left ventricular end-diastolic volume (LVEDV)), LV mass (LVM) and LV eccentricity index (LVei – a marker of pericardial restraint). Abdominal visceral (VAT) and epicardial (EAT) adipose tissue were also measured.ResultsPatients on average had lost 21kg (38.9% excess weight loss, EWL) at 212 days and 36kg (64.7% EWL) at 1030 days following bariatric surgery. Most VAT and EAT loss (43% and 14%, p

Abstract Background Empagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor that has demonstrated cardiovascular and renal protection in patients with type 2 diabetes (T2D). We hypothesized that empaglifozin (EMPA) could modulate ectopic fat stores and myocardial energetics in high-fat-high-sucrose (HFHS) diet mice and in type 2 diabetics (T2D). Methods C57BL/6 HFHS mice (n = 24) and T2D subjects (n = 56) were randomly assigned to 12 weeks of treatment with EMPA (30 mg/kg in mice, 10 mg/day in humans) or with placebo. A 4.7 T or 3 T MRI with 1H-MRS evaluation–myocardial fat (primary endpoint) and liver fat content (LFC)–were performed at baseline and at 12 weeks. In humans, standard cardiac MRI was coupled with myocardial energetics (PCr/ATP) measured with 31P-MRS. Subcutaneous (SAT) abdominal, visceral (VAT), epicardial and pancreatic fat were also evaluated. The primary efficacy endpoint was the change in epicardial fat volume between EMPA and placebo from baseline to 12 weeks. Secondary endpoints were the differences in PCr/ATP ratio, myocardial, liver and pancreatic fat content, SAT and VAT between groups at 12 weeks. Results In mice fed HFHS, EMPA significantly improved glucose tolerance and increased blood ketone bodies (KB) and β-hydroxybutyrate levels (p

The impact of glaciers on the Quaternary evolution of mountainous landscapes remains controversial. Although in situ or bedrock low-temperature thermochronology offers insights on past rock exhumation and landscape erosion, the method also suffers from potential biases due to the difficulty of sampling bedrock buried under glaciers. Detrital thermochronology attempts to overcome this issue by sampling sediments at e.g. the catchment outlet, a component of which may originate from beneath the ice. However, detrital age distributions not only reflect the catchment exhumation, but also spatially variable patterns and rates of surface erosion and sediment transport. In this study, we use a new version of a glacial landscape evolution model, iSOSIA, to address the effect of erosion and sediment transport by ice on the form of synthetic detrital age distributions. Sediments are tracked as Lagrangian particles formed by bedrock erosion, and their transport is restricted to ice or hillslope processes, neglecting subglacial hydrology, until they are deposited. We base our model on the Tiedemann Glacier (British Columbia, Canada), which has simple morphological characteristics, such as a linear form and no connectivity to large tributary glaciers. Synthetic detrital age distributions are generated by specifying an erosion history, then sampling sediment particles at the frontal moraine of the modelled glacier. Results show that sediment sources, reflecting different processes such as glacier and hillslope erosion, can have distinct bedrock age distribution signatures, and estimating such distributions should help to identify predominant sources in the sampling site. However, discrepancies between the detrital and bedrock age distributions occur due to (i) the selective storage of a large proportion of sediments in small tributary glaciers and in lateral moraines, (ii) the large range of particle transport times due to varying transport lengths and strong variability of glacier ice velocity, (iii) the heterogeneous pattern of erosion, and (iv) the advective nature of glacier sediment transport along ice streamlines. This last factor leads to a poor lateral mixing of particle detrital signatures inside the frontal moraine, and then local sampling of the frontal moraine is likely to reflect local sources upstream. Therefore, sampling randomly across the moraine is preferred for a more representative view of the catchment age distribution. Finally, systematic comparisons between synthetic (U-Th)/He and fission track detrital ages, with different bedrock age-elevation profiles and different relative age uncertainties, show that the nature of the age-elevation relationship and age uncertainties largely control the ability to track sediment sources in the detrital record. However, depending on the erosion pattern spatially, qualitative first-order information may still be extracted from a thermochronological system with high uncertainties (>30 %). Overall, our results demonstrate that detrital age distributions in glaciated catchments are strongly impacted not only by erosion and exhumation but also by sediment transport processes and their spatial variability. However, when combined with bedrock age distributions, detrital thermochronology offers a novel means to constrain the transport pattern and time of sediment particles.

It is difficult to separate an age-dependent fall in nitrogen use efficiency (NUE; N balance/N intake) in growing ruminants from a progressively decrease in animal protein requirements over time. This study examined the effect of dietary protein content on N partitioning, digestibility and N isotopic discrimination between the animal and its diet (Δ15Nanimal-diet) evaluated at two different fattening periods (early v. late). Twenty-four male Romane lambs (age: 19 ± 4.0 days; BW: 8.3 ± 1.39 kg) were equally allocated to three dietary CP treatments (15%, 17% and 20% CP on a DM basis). Lambs were reared with their mothers until weaning, thereafter housed in individual pens until slaughter (45 kg BW). During the post-weaning period, lambs were allocated twice (early fattening (30 days post-weaning) and late fattening (60 days post-weaning)) to metabolic cages for digestibility and N balance study. When diet CP content increased, the average daily gain of lambs increased (P < 0.05) while the age at slaughter decreased (P = 0.01), but no effect was observed on feed efficiency (P > 0.10). Diet CP content had limited effect on lamb carcass traits. Higher fibre digestibility was observed at the early v. late fattening period (P < 0.001). The N intake and the urinary N excretion increased when diet CP content increased (P < 0.001) and when shifting from early to late fattening period (P < 0.001). Faecal N excretion (P = 0.14) and N balance (P > 0.10) were not affected by diet CP content. Nitrogen digestibility increased (P < 0.001) as the diet CP content increased and on average it was greater at late v. early fattening period (P = 0.02). The NUE decreased (P = 0.001) as the diet CP content increased and as the lamb became older (P < 0.001). However, the age-dependent fall in NUE observed was lower at high v. low dietary CP content (CP × age interaction; P = 0.04). The Δ15Nanimal-diet was positively correlated (P < 0.05) with N intake (r = 0.59), excretion of faecal N (r = 0.41), urinary N (r = 0.69) and total manure N (r = 0.64), while negatively correlated with NUE (r = −0.57). Overall, the experiment showed NUE was lower in older lambs and when lambs were fed high diet CP content, and that Δ15Nanimal-diet was a useful indicator not only for NUE but also for urinary N excretion, which is a major environmental pollution factor on farm.

Abstract Assessing the impact of glaciations on topography and the co‐evolution of ice‐sheet dynamics requires a thorough understanding of the factors that control fjord morphology. We investigate the role of lithology on glacial valley form using topographic analyses and numerical landscape evolution models. We measure fjord depths and widths from East Central Greenland (68°N–75°N), and find a control of lithology on fjord width, with wider fjords in softer rocks (i.e., sedimentary rocks). This dependency of fjord width to bedrock properties is predicted by a quarrying erosion law, but not by an abrasion one, when considering results from a simple two‐dimensional model and a more detailed three‐dimensional ice flow model (iSOSIA). Our analyses and numerical results reveal a potential control of lithology on the width of glacial valleys with glacial quarrying as a plausible responsible mechanism.

Abstract Background The global prevalence of diabetes mellitus (DM) has been increasing over recent decades. In Germany, the prevalence for DM type 1 and type 2 in adults is estimated at about 7.7%. Hence, diabetes has to be classified as a serious public health concern. Being diagnosed with DM and facing possible sequelae might have a negative impact on patients’ mental and physical well-being. However, diabetes not only affects patients themselves, but also their close relatives. To improve the quality of life for patients and relatives alike, the German Association of Diabetes Nurses and Education experts (VDBD) elaborated the first education program tailor-made for relatives of diabetes patients. This article describes the concept and design of the trial evaluating the efficacy of this education program called “DiaLife—Living Together with Diabetes”. Methods This evaluation study is a cluster randomized controlled trial, in which the study centers will be randomly assigned either to the intervention group or the control group. Study centers will recruit relatives of and patients with DM type 1 and type 2. Members of the intervention group will participate in the education program DiaLife, whereas participants randomized in the control group will act as waiting-list controls. The study will assess the efficacy of DiaLife by comparing diabetes-related knowledge between the intervention and control groups as the primary outcome for participants. As the primary outcome in patients, the Hba1c value will be assessed. In addition, diabetes-related distress, family interaction, and other secondary endpoints will be considered as secondary outcomes. Long-term efficacy will be assessed 6 and 12 months after intervention. Hierarchical regression models will be used to analyze effects over time. Discussion While there is scientific evidence for the efficacy of education programs addressed to (diabetes) patients, there is a research gap with regard to intervention studies evaluating the efficacy of education programs designed for patients’ relatives. The study results will provide information on the efficacy of the DiaLife education program. In addition, factors that might hinder a successful implementation of an education program for relatives will be identified. Trial registration German Clinical Trials Register, DRKS00015157. Registered on 24 August 2018.

There is a lot of evidence that chicory could be a highly palatable and nutritious source of forage for ruminants, well adapted to climate change and dry conditions in summer, thanks to its resistance to drought and high water content. This study aimed to describe the effect of incorporating chicory to ryegrass or to a ryegrass–white clover mixture on feeding behaviour, digestive parameters, nitrogen (N) balance and methane (CH4) emissions in sheep. In total, three swards of ryegrass, white clover and chicory were established and managed in a manner ensuring the forage use at a constant vegetative stage throughout the experiment. In all, four dietary treatments (pure ryegrass; binary mixture: 50% ryegrass–50% chicory; ternary mixture: 50% ryegrass–25% white clover–25% chicory; and pure chicory) were evaluated in a 4×4 replicated Latin square design with eight young castrated Texel sheep. Each experimental period consisted of an 8-day diet adaptation phase, followed by a 6-day measuring phase during which intake dynamics, chewing activity, digestibility, rumen liquid passage rate, fermentation end-products, N balance and CH4 emissions were determined. Data were analysed using a mixed model and orthogonal contrasts were used to detect the potential associative effects between ryegrass and chicory. The daily voluntary dry matter intake was lower for pure ryegrass than for diets containing chicory (P

Summary: Background: Carbapenems are a family of end line antibiotics with increasing levels of resistance that are a cause for concern. Aim: To ascertain whether the CPE screening programme employed in an acute tertiary hospital is fit for purpose. Method: We outlined the current working algorithm employed using a universal screening programme over a 26-month screening period. Rectal swabs are cultured on arrival. Those with suspicious growth are further investigated using NG-Carba 5 lateral flow tests and Vitek 2.0 sensitivity cards. These practices were compared with NHS guidelines. Findings & Conclusions: In all, 53 true positives were detected from 45 patients since the screening was implemented in early 2018 (46 OXA-48, 6 KPC, 1 NDM). As the rate of screening increased, the number of positive screens decreased over time. There were a lot of similarities between the HSE guidelines and the published NHS CPE toolkit. It was evident that there is no standard practice being employed across all hospitals. Comparing the MUH to national guidelines it appears to be quicker and more effective with universal screening in place at reducing the potential contacts and identifying carriers. Cost analysis indicates that the need to confirm all positive strains in a reference lab is costly, unnecessary and time consuming. There are adequate confirmatory tests available in-house for routine positive screens. It was concluded that infection prevention and control are key to identifying and controlling possible outbreaks in a hospital setting.

Stress changes in GeTe thin films on silicon have been studied in situ as a function of temperature by optical curvature measurements. Crystallization of the initially amorphous layers is evidenced by a steep tensile stress buildup. The crystallization temperature is shown to be thickness-dependent for the thinner films. Various annealing conditions, such as cooling/re-heating steps and isothermal stages, allow exploring the thermo-mechanical behavior of the films. A non-thermoelastic temperature-dependent behavior is observed in the amorphous phase before crystallization. Keywords: Phase-change materials, GeTe, Thin films, Stress measurements, Thermomechanical behaviour

Background: A paucity of qualitative research on sensitive topics that focuses on participants with intellectual disabilities leaves their views unexplored. This scoping review mainly aimed to provide an overview of qualitative data collection methods used in research involving participants with intellectual disabilities to explore death and dying. Method: A scoping review of primary research and methodological papers published between January 2008 and March 2022 was conducted. The PRISMA-ScR checklist was followed. Results: We identified 25 articles utilising four data collection methods: interviews, focus groups, the Nominal Group Technique, and participant observation. Data collection trends were identified, including accommodations for participants with intellectual disabilities, visual media used as a facilitator, and reporting of distress protocols. Most participants had mild to moderate intellectual disabilities. Conclusions: The included studies demonstrate a flexible approach that relies on the use of multiple methods. Future research must adequately report study characteristics to ensure transparency and reliability.

End of 2011 a new optical satellite, called Pléiades, was launched by the French space agency (CNES). It provides 20 km x 20 km images at 0.5 meters. This agile acquisition system is able to relocate very rapidly and scan the earth in any direction. The agility of the system offers the ability to acquire multi viewing angle images of the same area during the same orbit. This ability to capture, from a single stereoscopic pair, to a sequence of 25 images, allows enhancing the quality and the completeness of automatically extracted 3D maps. The aim of the study is to validate and quantify the capacity of the Pléiades system to perform 3D mapping. The analysis explores the advantages in terms of quality and automatism to use more than 2 stereoscopic images. In the last 10 years, automatic 3D processing of digital images became more and more popular and efficient. Thanks to aerial images with very large overlap and very high resolution satellite images, new methodologies and algorithms have been implemented to improve the quality and accuracy of automatic 3D processing. We propose to experiment the same type of approaches using Pléiades images to produce digital elevation models (DEM). A focus is made on analysing the 3D processing using video like (multi viewing) acquisitions. Different reference sites with very accurate 3D control points are used to quantify the quality of the Pléiades DEM. Different acquisition modes are explored from a single stereo pair to a sequence of 17 images.

On the one hand, onboard SPOT 5, the HRS instrument systematically collects stereopairs around the Globe since 2002. Each stereopair can encompass an area up to 600 km x 120 km within a single pass (i.e. 72 000 km² stereoscopic strips). Covering now more than 120 millions sq.km of the Earth landmasses, SPOT 5 stereoscopic imagery has become one of main satellite data sources for accurate DEM extraction, at least where the cloud coverage leaves a chance to do so ! On the other hand, the TerraSAR-X satellite, launched in June 2007, is able to collect radar data through the clouds in several modes. An approach to extract height information by radargrammetry was developed, and the commercial distribution of Digital Elevation Models based on TerraSAR-X StripMap and SpotLight Modes (resp. 3m and 1m resolution) has started in 2010. To improve the overall height accuracy of the DEM, acquisitions from both orbit directions are utilised, each point on the ground being thus imaged at least 4 times by TerraSAR-X. Since 2002, Spot Image and French National Cartographic Institute (IGN) are building a worldwide database called Elevation30/Reference3D™, which includes a Digital Elevation Model at 1-arc-second resolution (DTED level 2) extracted from HRS stereopairs. To answer the wide demand of precise DEMs over Tropical and Northern areas, frequently covered by clouds, a study was performed to integrate StripMap radargrammetric TerraSAR-X data into the Reference3D process, and two prototype products were issued, over Colombia and Congo areas. During this experiment, efforts have been made to stick to technical steps that could be integrated within a standardized production process, in order to keep offering affordable prices while maintaining a high standard of horizontal and vertical accuracy. The DEMs extracted from TerraSAR-X and HRS proved extremely consistent with each other, showing a mean difference of 0.80m. This allows to propose a unified Elevation30 product to the users, with a guaranteed accuracy materialized into the product through a dedicated vertical Accuracy Commitment Mask.

By the end of 2011, Astrium GEO-Information Services launched Pléiades 1, the first of two identical optical imaging satellites that will be operated on a phased orbit. This satellite system, designed by the French Space Agency, CNES, based upon French Defense specifications, will provide 50-cm products in record time. The overall aim of this paper is to describe the benefits of the innovative features of Pléiades 1 and its operations, so as to assess their combined potential in emergency situations, crisis recovery, regular monitoring or large area mapping. Specific care will be brought to describe the reactivity enabled by the system. Based on real-life examples, the paper will lead the analysis on the two main components of the system. On the one hand, the space segment will be presented through the following characteristics: revisit capacity, agility, acquisition capacity and acquisition scenarios (target, single-pass mosaics, stereo, tristereo, linear monitoring, persistent surveillance). On the other hand, the flexibility of the ground segment will be assessed. The benefits of multiple tasking plans per day, direct tasking capacity, automated processing and on-line ordering and delivering will be illustrated, tested and qualified for applications requiring a high level of responsiveness and reactivity. The presentation will end with a summary of the benefits of the space segment features and the flexibility of the ground segment, fine-tuned to answer both military and civilian / commercial needs. The analysis will be extended in the perspective of the second Pléiades' launch, highlighting the advantages of having two satellites operating on a phased orbit, affording a daily revisit anywhere on Earth, with very high resolution.

For more than twenty years the strait of Maracaibo and El Tablazo Bay, in the Lake of Maracaibo, have been used as discharge sites for industrial and domestic waters. Annually, the Instituto de Canalizaciones dredges the channel, activity that produces dispersion of contaminants in the water column. In this paper the evaluation of Mercury concentration in interstitial water and sediments from the channel (resuspended material) and water column and sediments in the navigation channel and from nearby ports is done. The results were analyzed in accordance to Venezuela's legislation and international legislation for dredging activities. There is a legal gap in Venezuela's regulation for disposal of dredged material. The Hg concentration on sediments is higher on some points than EPA's regulation for open disposal. The Hg concentration on fish tissues indicate the influence on the trophic chain, that could develop in a health problem in the future.