3,246 results on '"M. Barr"'
Search Results
2. List of Contributors
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Agrawal, Pankaj B., primary, Akhtar, Yasmin, additional, Alallah, Jubara, additional, Alhassen, Ziad, additional, Altit, Gabriel, additional, AlZubaidi, Abbas, additional, Amlani, Lahin M., additional, Antelo, Martin, additional, Athalye-Jape, Gayatri, additional, Badarch, Jargalsaikhan, additional, Baer, Gerri, additional, Bagga, Nitasha, additional, Bahr, Timothy M., additional, Bar-Cohen, Yaniv, additional, M. Barr, Stephanie, additional, Bauer, Andrew J., additional, Bearer, Cynthia F., additional, Beckman, Ross M., additional, Beltempo, Marc, additional, Bembea, Melania M., additional, Berlin, Sheila, additional, Berry, Shandeigh N., additional, Bhandari, Vineet, additional, Bhatia, Shaifali, additional, Bhombal, Shazia, additional, Bigelow, Elaine O., additional, Blevins, Carley, additional, Boppana, Suresh, additional, Boss, Renee, additional, Brooks, Sandra, additional, Buonocore, Giuseppe, additional, Burnsed, Jennifer, additional, Calabria, Andrew C., additional, Carrasco, Melisa, additional, Carter, Brian S., additional, Chandrasekharan, Praveen, additional, Chavez-Valdez, Raul, additional, Choleva, Lauryn, additional, Christensen, Robert D., additional, Chung, Wendy K., additional, Coggins, Sarah A., additional, Cooke, David W., additional, Cummings, Laura, additional, Currie, Erin R., additional, Davidson, Joanne O., additional, Davis, Jonathan M., additional, Day-Richardson, Colby L., additional, De Leon, Diva D., additional, Dedhia, Kavita, additional, Dendi, Alvaro, additional, Deshpande, Anita, additional, Dionne, Janis M., additional, Donda, Keyur, additional, Donohue, Lee, additional, Doyle, Jefferson J., additional, Dulkerian, Susan J., additional, Dumpa, Vikramaditya, additional, Duncan, Andrea F., additional, Dunham, Alexandra M., additional, Ecret, DiAnn, additional, Ellis, Kelstan, additional, El-Metwally, Dina, additional, Etchill, Eric W., additional, Ethawi, Yahya, additional, Everett, Allen D., additional, Fabres, Jorge, additional, Felling, Ryan J., additional, Fenton, Tanis R., additional, Flannery, Dustin D., additional, Flynn, Joseph T., additional, Fredenburg, Michaelene, additional, Fuqua, John, additional, Garcia, Alejandro V., additional, Garzon, Steven, additional, Gauda, Estelle B., additional, Thompson, Marisa Gilstrop, additional, Goldenberg, Barton, additional, Salazar, Andres J. Gonzalez, additional, Goodwin, Julie E., additional, Goudy, Steven L., additional, Graham, Ernest, additional, Grauerholz, Kathryn, additional, Groves, Mari L., additional, Guillot, Mireille, additional, Gunn, Alistair J., additional, Gupta, Arjun, additional, Hackam, David J., additional, Hidalgo, Joaquin, additional, Honcharuk, Erin, additional, Htun, Zeyar, additional, Hudak, Mark L., additional, Driscoll, Colleen A. Hughes, additional, Huisman, Thierry A.G.M., additional, Jabroun, Mireille, additional, Jackson, Eric M., additional, Jain, Naveen, additional, Jain, Rajesh, additional, Jelin, Angie, additional, Jelin, Eric, additional, Juul, Sandra E., additional, Kaufman, David A., additional, BMBS, Alison Kent,, additional, Khuder, Sundos, additional, Kovler, Mark L., additional, Kraus, Courtney L., additional, Krishnamurthy, Ganga, additional, Kukora, Stephanie K., additional, Kumar, Ashok, additional, Kunisaki, Shaun M., additional, Kuper-Sassé, Margaret, additional, Kwiatkowski, David M., additional, Lakshminrusimha, Satyan, additional, Laventhal, Naomi T., additional, Lawrence, Shelley M., additional, Lee-Winn, Angela E., additional, Leuthner, Steven, additional, Lewallen, Laura, additional, Lewis, Tamorah R., additional, Liken, Hillary B., additional, Liubšys, Arūnas, additional, Lui, Kei, additional, Maheshwari, Akhil, additional, Maitre, Nathalie L., additional, Makker, Kartikeya, additional, Mammen, Cherry, additional, J. Martin, Richard, additional, Mattos Castellano, María, additional, Maxwell, Jessie R., additional, McFarlane, Renske, additional, McLemore, Gabrielle, additional, McNelis, Kera M., additional, McPherson, Christopher, additional, Mietzsch, Ulrike, additional, Milante, Rachel R., additional, Miller, Jena L., additional, Mukhopadhyay, Sagori, additional, Mynak, Mimi L., additional, Nasr, Isam W., additional, Natarajan, Niranjana, additional, Navaneethan, Hema, additional, Nees, Shannon N., additional, Nguyen, Mai, additional, Noori, Shahab, additional, Odackal, Namrita J., additional, Ohls, Robin K., additional, Ostrander, Betsy E., additional, Pammi, Mohan, additional, Parimi, Prabhu S., additional, Park, Albert, additional, Patil, Monika S., additional, Pereira, Elaine M., additional, Premkumar, Muralidhar H., additional, Price-Douglas, Webra, additional, Puopolo, Karen M., additional, Rabe, Heike, additional, M. Rahman, Mohammad, additional, Reber, Kristina, additional, Kallem, Venkat Reddy, additional, Repka, Michael X., additional, Rhee, Daniel S., additional, Ringle, Megan L., additional, Rohrer, Allison, additional, Romero, Christopher J., additional, Ryan, Marisa A., additional, Sampah, Maame E.S., additional, Sanchez-Valle, Amarilis, additional, Sant’Anna, Guilherme M., additional, Saugstad, Ola D., additional, RobertH., Anne and, additional, Schacht, John P., additional, Schelonka, Robert L., additional, Schofield, Erin E., additional, Selewski, David T., additional, Shah, Prakesh S., additional, Shih, Jessica G., additional, Sibinga, Erica M.S., additional, Sigal, Winnie, additional, Sims, Brian, additional, Singh, Rachana, additional, Singh, Srijan, additional, Snyder, Donna, additional, Sobrero, Helena, additional, Sponseller, Paul D., additional, Stafstrom, Carl E., additional, Steflik, Heidi J., additional, Sun, Lisa R., additional, Sundararajan, Sripriya, additional, Taylor, Sarah N., additional, Terrin, Norma, additional, Thacker, Prolima G., additional, Thébaud, Bernard, additional, Toms, Rune, additional, Torres, Benjamin A., additional, Tunkel, David E., additional, Umandap, Christine H., additional, Chaves, Diana Vargas, additional, Vento, Maximo, additional, Walsh, Jonathan, additional, Walter, Jolan, additional, Weaver, Meaghann S., additional, Weimer, Kristin, additional, Weller, Jennine, additional, Winter, Lindy W., additional, Wu, Tai-Wei, additional, and Yau, Mabel, additional
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- 2024
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3. Deepfake Labels Restore Reality, Especially for Those Who Dislike the Speaker.
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Nathan L. Tenhundfeld, Ryan Weber, William I. MacKenzie, Hannah M. Barr, and Candice L. Lanius
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- 2024
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4. Forest and fishing industries
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M. Barr, Brenton, primary
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- 2023
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5. Malocclusion in children with speech sound disorders and motor speech involvement: a cross-sectional clinical study in Swedish children
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Mogren, Å., Havner, C., Westerlund, A., Sjögreen, L., Agholme, M. Barr, and Mcallister, A.
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- 2022
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6. Is My Siri the Same as Your Siri? An Exploration of Users' Mental Model of Virtual Personal Assistants, Implications for Trust.
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Nathan L. Tenhundfeld, Hannah M. Barr, Emily H. O'Hear, and Kristin Weger
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- 2022
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7. U-Pb zircon ages from metasedimentary and plutonic rocks in the Bras d'Or terrane of Cape Breton Island, Nova Scotia, Canada: insights into the Ediacaran–Cambrian tectonomagmatic evolution of Ganderia
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Deanne van Rooyen, Sandra M. Barr, Chris E. White, and James L. Crowley
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General Earth and Planetary Sciences - Abstract
The Bras d'Or terrane of central Cape Breton Island, Nova Scotia, Canada, contains a well-preserved record of the Ediacaran to early Cambrian evolution of Ganderia, a Gondwana-derived terrane in the northern Appalachian orogen. A complex assemblage of low- to high-grade metasedimentary rocks has varied detrital zircon signatures from laser ablation inductively coupled plasma mass spectrometry U-Pb zircon dating, but combining three or more samples yielded representative age spectra that support correlation of the low- and high-grade metasedimentary rocks throughout the Bras d'Or terrane and the corresponding Ganderian Brookville terrane of southern New Brunswick. In quartzite samples from the McMillan Flowage Formation in the northwestern Bras d'Or terrane, the youngest detrital zircons have ages >900 Ma, in contrast to previously studied psammitic and semipelitic samples from correlative units in the eastern Bras d'Or terrane in which youngest detrital ages are 620–600 Ma. Both quartzite and semipelitic samples from the McMillan Flowage Formation contain Neoproterozoic dates from zircon rims, which reflect metamorphic overgrowths during peak metamorphism at ca. 550 Ma, providing a robust age for peak metamorphism in the Bras d'Or terrane that supports similar, albeit sparse, ages reported previously from monazite and titanite samples. This metamorphism is coeval with the emplacement of voluminous dioritic to granitic plutons that occur throughout the Bras d'Or terrane and form in an Andean-type continental margin subduction zone. New U-Pb zircon ages presented here from plutons in the northern Bras d'Or terrane, combined with previously published ages, are consistent with subduction-related magmatism and associated metamorphism between ca. 575 and 540 Ma.
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- 2023
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8. Environmental Geology of Barite Deposits in Nevada
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L. Donkervoort, A. Prestia, R. Griffiths, R. J. Bowell, K. Fallowfield, and M. Barr
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Geophysics ,Geochemistry and Petrology ,Economic Geology ,Geology - Abstract
Barite is an important industrial mineral used as a weighing agent in fluids during the drilling of oil and natural gas wells, with the majority of United States production originating from Nevada. This paper considers three barite properties at varying stages of development—Rossi, Heavy Spar, and Ann—all located within the northern Nevada barite belt. At all three sites, barite is hosted in the Roberts Mountains allochthon consisting of siliceous sedimentary rocks. Geochemical characterization of waste rock, ore, and process products has been undertaken as part of project development at each site, including 212 acid-base accounting (ABA) analysis and 19 humidity-cell tests operated for up to 114 weeks. This study demonstrates that the presence of barite greatly limits the application of using traditional Sobek-style ABA methods. Barite will undergo incomplete dissolution and extraction in the ABA tests that will result in an overprediction of acid generation for materials that contain barite (i.e., ore and jig by-products). Results indicate use of the net acid generation test to inform waste rock management represents a more reliable indicator of acid generation for these three deposits and potentially also other barite deposits. Potential barite mine sites should continue to be evaluated using the same geochemical testing tools as base metal mines but using those tools in a selective way to achieve balance between regulatory requirements and costs.
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- 2023
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9. Precise U–Pb zircon dates from silicic super-eruptions during late Ediacaran extension in the Avalonian Caledonia terrane of southern New Brunswick, Canada
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Alicia P. Escribano, Sandra M. Barr, and James L. Crowley
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General Earth and Planetary Sciences - Abstract
The Coldbrook Group and related plutons in the Caledonian Highlands of southern New Brunswick contain voluminous late Ediacaran silicic rocks formed in a magmatic event not recognized in other parts of Avalonia in the northern Appalachian orogen. To better constrain the age and origin of these rocks, we used U–Pb zircon dating by laser ablation inductively coupled plasma mass spectrometry to check for older inherited zircon and obtain trace element data, followed by chemical abrasion isotope dilution thermal ionization mass spectrometry (CA-TIMS) to obtain precise dates. Four silicic samples were dated from the Coldbrook Group, one from the Bonnell Brook pluton, and, for comparison, a felsic lithic-crystal tuff sample from the older arc-related Broad River Group. Overlapping CA-TIMS dates of 551.57 ± 0.23, 551.38 ± 0.24, and 551.70 ± 0.20 Ma for samples from the lower, middle, and upper Coldbrook Group, respectively, and 551.71 ± 0.19 Ma for granite from the Bonnell Brook pluton show that these units crystallized in 760 000 years or less, consistent with a super-eruption event. Rhyolite from the uppermost unit of the Coldbrook Group yielded a younger date of 549.18 ± 0.09 Ma, but the large extent of that unit is consistent with the possibility of a second younger super-eruption. The felsic lithic-crystal tuff sample from the Broad River Group yielded a date of 615.48 ± 0.16 Ma, consistent with previously published dates from that group and associated plutons. Differences in zircon chemistry between the Broad River Group sample and the late Ediacaran samples are consistent with the contrasting subduction-related vs within-plate extensional tectonic settings as suggested by previous studies of whole-rock petrological characteristics of the two age groups.
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- 2023
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10. Cannabidiol‐associated hepatotoxicity: A systematic review and meta‐analysis
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Lindsay A. Lo, April Christiansen, Lauren Eadie, Justin C. Strickland, David D. Kim, Michael Boivin, Alasdair M. Barr, and Caroline A. MacCallum
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Internal Medicine - Published
- 2023
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11. The Terreneuvian MacCodrum Brook section, Mira terrane, Cape Breton Island, Nova Scotia, Canada: age constraints from ash layers, organic-walled microfossils, and trace fossils
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Sandra M. Barr, Chris E. White, Teodoro Palacios, Sören Jensen, Deanne van Rooyen, and James L. Crowley
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General Earth and Planetary Sciences - Abstract
The MacCodrum Formation is a classical “lower” Cambrian unit in southeastern Cape Breton Island stratigraphy, described since the 1800s. The age of this formation and its correlation with other Avalonian Cambrian units in eastern Newfoundland and southern New Brunswick have remained uncertain through numerous revisions. Here we present U-Pb CA-TIMS ages from an ash bed in the basal part of the MacCodrum Formation in its type-section on MacCodrum Brook that fix the maximum time of deposition at 531.86 ± 0.34 Ma. Organic-walled microfossils sampled throughout the MacCodrum Formation type-section yield acritarch taxa identifying the Asteridium– Comasphaerdium Zone, whereas the first acritarchs of the Skiagia– Fimbriaglomerella Zone appear in the overlying Canoe Brook Formation in other sections. The radiometric age and acritarch zonation place the MacCodrum Formation in the upper Fortunian, Cambrian Stage 2. Among trace fossils in the MacCodrum Formation, the meandering trace fossil Didymaulichnus dailyi comb. nov. is of particular note and morphologically identical to the type material from the lower part of the Ratcliffe Brook Formation in New Brunswick. The new radiometric and biostratigraphic data presented here provide the first firm constraints on the age of the MacCodrum Formation and enable more precise correlation with sections in southern New Brunswick and eastern Newfoundland.
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- 2023
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12. Using serial position effects to investigate memory dysfunction in homeless and precariously housed persons
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Kristina M. Gicas, Katie Benitah, Allen E. Thornton, Anna M. Petersson, Paul W. Jones, Jacob L. Stubbs, Andrea A. Jones, William J. Panenka, Donna J. Lang, Olga Leonova, Fidel Vila-Rodriguez, Alasdair M. Barr, Tari Buchanan, Wayne Su, Alexandra T. Vertinsky, Alexander Rauscher, G. William MacEwan, and William G. Honer
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Psychiatry and Mental health ,Clinical Psychology ,Neuropsychology and Physiological Psychology ,Arts and Humanities (miscellaneous) ,Developmental and Educational Psychology - Published
- 2023
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13. P648: REAL-WORLD TREATMENT AND OUTCOMES OF PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) RECEIVING FIRST-LINE (1L) THERAPY IN THE NOVEL AGENT ERA: AN INTERNATIONAL STUDY
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Lansigan, Frederick, primary, A. Eyre, Toby, additional, Ghosh, Nilanjan, additional, S. Manzoor, Beenish, additional, C. Coombs, Catherine, additional, Lamanna, Nicole, additional, H. Tuncer, Hande, additional, Emechebe, Dozie, additional, R. Brown, Jennifer, additional, E. Roeker, Lindsey, additional, Ujjani, Chaitra, additional, Alhasani, Hasan, additional, Fleury, Isabelle, additional, A. Leslie, Lori, additional, Skarbnik, Alan, additional, Rhodes, Joanna, additional, T. Hill, Brian, additional, M. Barr, Paul, additional, S. Davids, Matthew, additional, P. Fox, Christopher, additional, Choi, Yun, additional, Schuh, Anna, additional, Kennard, Kaitlin, additional, E. Jensen, Christopher, additional, Jawaid, Dureshahwar, additional, Sharma, Aditya, additional, Pivneva, Irina, additional, Watson, Talissa, additional, and Shadman, Mazyar, additional
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- 2023
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14. P627: LONG-TERM OUTCOMES WITH CONTINUOUS IBRUTINIB IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA: ANALYSIS OF TIME TO PROGRESSION
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Kipps, Thomas, primary, Owen, Carolyn, additional, W. Flinn, Ian, additional, M. Barr, Paul, additional, Tedeschi, Alessandra, additional, Greil, Richard, additional, Szafer-Glusman, Edith, additional, Huang, Hsin-Hui, additional, Neumayr, Lynne, additional, Abbazio, Chris, additional, and Shanafelt, Tait, additional
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- 2023
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15. A phase 1b study of ibrutinib in combination with obinutuzumab in patients with relapsed or refractory chronic lymphocytic leukemia
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Christine E. Ryan, Danielle M. Brander, Paul M. Barr, Svitlana Tyekucheva, Liam R. Hackett, Mary C. Collins, Stacey M. Fernandes, Yue Ren, Yinglu Zhou, Mikaela M. McDonough, Heather A. Walker, Monica R. McEwan, Jeremy S. Abramson, Eric D. Jacobsen, Ann S. LaCasce, David C. Fisher, Jennifer R. Brown, and Matthew S. Davids
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Cancer Research ,Oncology ,Hematology - Published
- 2023
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16. Risk of kidney disease following a pregnancy complicated by diabetes: a longitudinal, population-based data-linkage study among Aboriginal women in the Northern Territory, Australia
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Matthew J. L. Hare, Louise J. Maple-Brown, Jonathan E. Shaw, Jacqueline A. Boyle, Paul D. Lawton, Elizabeth L. M. Barr, Steven Guthridge, Vanya Webster, Denella Hampton, Gurmeet Singh, Roland F. Dyck, and Federica Barzi
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Endocrinology, Diabetes and Metabolism ,Internal Medicine - Abstract
Aims/hypothesis The aim of this work was to investigate the risk of developing chronic kidney disease (CKD) or end-stage kidney disease (ESKD) following a pregnancy complicated by gestational diabetes mellitus (GDM) or pre-existing diabetes among Aboriginal women in the Northern Territory (NT), Australia. Methods We undertook a longitudinal study of linked healthcare datasets. All Aboriginal women who gave birth between 2000 and 2016 were eligible for inclusion. Diabetes status in the index pregnancy was as recorded in the NT Perinatal Data Collection. Outcomes included any stage of CKD and ESKD as defined by ICD-10 coding in the NT Hospital Inpatient Activity dataset between 2000 and 2018. Risk was compared using Cox proportional hazards regression. Results Among 10,508 Aboriginal women, the mean age was 23.1 (SD 6.1) years; 731 (7.0%) had GDM and 239 (2.3%) had pre-existing diabetes in pregnancy. Median follow-up was 12.1 years. Compared with women with no diabetes during pregnancy, women with GDM had increased risk of CKD (9.2% vs 2.2%, adjusted HR 5.2 [95% CI 3.9, 7.1]) and ESKD (2.4% vs 0.4%, adjusted HR 10.8 [95% CI 5.6, 20.8]). Among women with pre-existing diabetes in pregnancy, 29.1% developed CKD (adjusted HR 10.9 [95% CI 7.7, 15.4]) and 9.9% developed ESKD (adjusted HR 28.0 [95% CI 13.4, 58.6]). Conclusions/interpretation Aboriginal women in the NT with GDM or pre-existing diabetes during pregnancy are at high risk of developing CKD and ESKD. Pregnancy presents an important opportunity to identify kidney disease risk. Strategies to prevent kidney disease and address the social determinants of health are needed. Graphical abstract
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- 2023
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17. Posttraumatic stress in the trans community: The roles of anti-transgender bias, non-affirmation, and internalized transphobia
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Jill L. Adelson, Stephanie L. Budge, Sebastian M. Barr, and Kate E. Snyder
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Gender Studies ,Posttraumatic stress ,Transgender ,Psychology ,Test bias ,General Psychology ,Transphobia ,Clinical psychology - Published
- 2022
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18. Many people with chronic lymphocytic leukemia or small lymphocytic lymphoma benefit from ibrutinib treatment up to 8 years: a plain language summary
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Paul M Barr, Carolyn Owen, Tadeusz Robak, Alessandra Tedeschi, Osnat Bairey, Jan A Burger, Peter Hillmen, Claire Dearden, Sebastian Grosicki, Helen McCarthy, Jian Yong Li, Fritz Offner, Carol Moreno, Mandy Jermain, Cathy Zhou, Emily Hsu, Anita Szoke, Thomas J Kipps, and Paolo Ghia
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Cancer Research ,Oncology ,General Medicine - Abstract
What is this summary about? This is a plain language summary of a publication describing long-term results from the RESONATE-2 study with up to 8 years of follow-up. The original paper was published in Blood Advances in June 2022. What were the results? Researchers looked at 269 adults with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who had not received any treatment for their CLL/SLL. Study participants were randomly divided into two groups: 136 participants received treatment with a drug called ibrutinib, and 133 participants received treatment with a drug called chlorambucil. Participants in the study were treated and followed for up to 8 years, with results showing that more participants who took ibrutinib (59%) were alive without worsening of their disease at 7 years after starting treatment than participants who took chlorambucil (9%). Almost half of the participants (42%) were able to stay on ibrutinib treatment for up to 8 years. What do the results of the study mean? In people with CLL or SLL, more participants who were taking ibrutinib were alive without worsening of their disease after 7 years compared with participants who took chlorambucil. Clinical Trial Registration: NCT01722487 ( ClinicalTrials.gov ) Clinical Trial Registration: NCT01724346 ( ClinicalTrials.gov )
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- 2022
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19. Does My Driver Share My Moral View? Effects of Humanlikeness and Morality in an Adapted Trolley Problem
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Andrew Atchley, Hannah M. Barr, Emily H. O’Hear, Carly E. Gray, Amber F. Chesser, Nicholaos Jones, and Nathan L. Tenhundfeld
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Medical Terminology ,Medical Assisting and Transcription - Abstract
As autonomous systems become responsible for more complex decisions, it is crucial to consider how these systems will respond in situations wherein they must make potentially controversial decisions without input from users. While previous literature has suggested that users prefer machinelike systems that act to promote the greater good, little research has focused on how the humanlikeness of an agent influences how moral decisions are perceived. We ran two online studies where participants and an automated agent made a decision in an adapted trolley problem. Our results conflicted with previous literature as they did not support the idea that humanlike agents are trusted in a manner analogous to humans in moral dilemmas. Conversely, our study did support the importance for trust of shared moral view between users and systems. Further investigation is necessary to clarify how humanlikeness and moral view interact to form impressions of trust in a system.
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- 2022
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20. Effective Tumor Debulking with Ibrutinib Before Initiation of Venetoclax: Results from the CAPTIVATE Minimal Residual Disease and Fixed-Duration Cohorts
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Paul M. Barr, Alessandra Tedeschi, William G. Wierda, John N. Allan, Paolo Ghia, Daniele Vallisa, Ryan Jacobs, Susan O'Brien, Andrew P. Grigg, Patricia Walker, Cathy Zhou, Joi Ninomoto, Gabriel Krigsfeld, and Constantine S. Tam
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Sulfonamides ,Cancer Research ,Neoplasm, Residual ,Piperidines ,Oncology ,Adenine ,Creatinine ,Antineoplastic Combined Chemotherapy Protocols ,Humans ,Cytoreduction Surgical Procedures ,Bridged Bicyclo Compounds, Heterocyclic ,Tumor Lysis Syndrome ,Leukemia, Lymphocytic, Chronic, B-Cell - Abstract
Purpose: The phase II CAPTIVATE study investigated first-line treatment with ibrutinib plus venetoclax for chronic lymphocytic leukemia in two cohorts: minimal residual disease (MRD)-guided randomized treatment discontinuation (MRD cohort) and fixed duration (FD cohort). We report tumor debulking and tumor lysis syndrome (TLS) risk category reduction with three cycles of single-agent ibrutinib lead-in before initiation of venetoclax using pooled data from the MRD and FD cohorts. Patients and Methods: In both cohorts, patients initially received three cycles of ibrutinib 420 mg/day then 12 cycles of ibrutinib plus venetoclax (5-week ramp-up to 400 mg/day). Results: In the total population (N = 323), the following decreases from baseline to after ibrutinib lead-in were observed: percentage of patients with a lymph node diameter ≥5 cm decreased from 31% to 4%, with absolute lymphocyte count ≥25 × 109/L from 76% to 65%, with high tumor burden category for TLS risk from 23% to 2%, and with an indication for hospitalization (high TLS risk, or medium TLS risk and creatinine clearance Conclusions: Three cycles of ibrutinib lead-in before venetoclax initiation provides effective tumor debulking, decreases the TLS risk category and reduces the need for hospitalization for intensive monitoring for TLS.
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- 2022
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21. Interphase boundary, grain boundary, and surface diffusion in Al2O3-GdAlO3 composites determined from bicrystal coble creep experiments
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D. Keith Coffman, Yonghui Ma, Christopher M. Barr, Jia-hu Ouyang, Khalid Hattar, and Shen J. Dillon
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Materials Chemistry ,Ceramics and Composites - Published
- 2022
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22. Reduction in Substance-Related Composite Harm Scores Through Street Soccer
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Alan T Bates, Lurdes Tse-Agha, Arun Agha, John-Jose Nunez, Heidi N Boyda, Andrea A Jones, Alasdair M Barr, William G Honer, and Fidel Vila-Rodriguez
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General Engineering - Published
- 2023
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23. Healthcare Utilization Disparities of Adolescent and Young Adults compared to the Older Lymphoma Population
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Kriti Thapa, Myla Strawderman, Patrick M. Reagan, Paul M. Barr, Clive S. Zent, Jonathan W. Friedberg, Tina Faugh, and Carla Casulo
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Cancer Research ,Oncology ,Hematology - Published
- 2023
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24. Brentuximab Vedotin Combined with Chemotherapy in Newly Diagnosed, Early-Stage, Unfavorable-Risk Hodgkin Lymphoma: Extended Follow-up with Evaluation of Baseline Metabolic Tumor Volume and PET2
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Robert Stuver, Laure Michaud, Carla Casulo, Ranjana H. Advani, Elizabeth L. Budde, Paul M. Barr, Connie Lee Batlevi, Philip C Caron, Louis S. Constine, Savita Dandapani, Pamela Drullinsky, Jonathan W. Friedberg, Clare Grieve, Audrey Hamilton, Paul A. Hamlin, Richard Hoppe, Steven M. Horwitz, Niloufer Khan, Matthew J. Matasar, Ariela Noy, M.Lia Palomba, Heiko Schoder, David J. Straus, Shreya Vemuri, Joachim Yahalom, Joanna C. Yang, Anas Younes, Andrew D. Zelenetz, Craig H. Moskowitz, Anita Kumar, and Alison J. Moskowitz
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Immunology ,Cell Biology ,Hematology ,Biochemistry - Published
- 2022
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25. Initiating First-Line (1L) Ibrutinib (Ibr) in Patients (pts) with Chronic Lymphocytic Leukemia (CLL) Improves Overall Survival (OS) Outcomes to Rates Approximating an Age-Matched Population of ≥65 Years
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Paolo Ghia, Carolyn Owen, Jacqueline C. Barrientos, Paul M. Barr, Anthony R. Mato, Chunxue Shi, Anita Szoke, Chris Abbazio, Gabriel S. Krigsfeld, and Jan A. Burger
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Immunology ,Cell Biology ,Hematology ,Biochemistry - Published
- 2022
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26. Psychologically Informed Practice in Audiological Rehabilitation: Audiologist Perceived Barriers, Facilitators, and Preparedness
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Emma C. Laird, Christina A. Bryant, Caitlin M. Barr, and Rebecca J. Bennett
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Speech and Hearing ,Otorhinolaryngology - Published
- 2022
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27. Constraints on the age of Archaeozoon acadiense and evidence for hydrothermally transported zircon in the Ashburn Formation (Green Head Group), Saint John, New Brunswick, Canada
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Donald W. Davis, Sandra M. Barr, and Chris E. White
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General Earth and Planetary Sciences - Abstract
Zircon grains from metasiltstone beds in the Precambrian Ashburn Formation were dated to constrain the age of the stromatolite Archaeozoon acadiense. The largest group of analyzed grains consists of mostly well-rounded detrital zircon no younger than 1060 Ma with significant peaks at about 1200–1100, 1500, 1800, 2050, and 2700 Ma, as well as a few Mesoarchean ages. A second population of apparently euhedral grains gives ages in the range 680–400 Ma. The distribution of detrital zircon ages along with field relationships suggest that the Ashburn and Martinon formations are proximal and distal parts of the Green Head Group, respectively, and hence a previously reported maximum depositional age of ca. 602 ± 8 Ma for the Martinon Formation also applies to stromatolite in the Ashburn Formation. Paleozoic zircon recovered from the Ashburn Formation cannot be detrital because the rocks were intruded and contact metamorphosed by the Golden Grove Plutonic Suite at ca. 550–525 Ma. The Paleozoic zircon grains were found in four independently processed samples and have also been seen in other studies in the region, showing that they are not due to laboratory contamination. Zircon formed during younger magmatic activity may have been transported in hydrothermal fluids and emplaced into these metasedimentary rocks in veins. A single euhedral zircon recovered from an atypically thick vein gave an age of 659 ± 33 Ma. Hydrothermally transported zircon might provide a window into younger igneous processes for which evidence is not otherwise preserved in this and other areas.
- Published
- 2022
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28. Measurement of the double-differential inclusive jet cross section in proton-proton collisions at s $$ \sqrt{s} $$ = 5.02 TeV
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The CMS collaboration, A. Hayrapetyan, A. Tumasyan, W. Adam, J. W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, A. Escalante Del Valle, P. S. Hussain, M. Jeitler, N. Krammer, L. Lechner, D. Liko, I. Mikulec, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, M. R. Darwish, T. Janssen, T. Kello, P. Van Mechelen, E. S. Bols, J. D’Hondt, A. De Moor, M. Delcourt, H. El Faham, S. Lowette, I. Makarenko, A. Morton, D. Müller, A. R. Sahasransu, S. Tavernier, S. Van Putte, D. Vannerom, B. Clerbaux, S. Dansana, G. De Lentdecker, L. Favart, D. Hohov, J. Jaramillo, K. Lee, M. Mahdavikhorrami, A. Malara, S. Paredes, L. Pétré, N. Postiau, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, M. De Coen, D. Dobur, J. Knolle, L. Lambrecht, G. Mestdach, C. Rendón, A. Samalan, K. Skovpen, M. Tytgat, N. Van Den Bossche, B. Vermassen, L. Wezenbeek, A. Benecke, G. Bruno, F. Bury, C. Caputo, C. Delaere, I. S. Donertas, A. Giammanco, K. 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Yan, A. G. Zecchinelli, G. Agarwal, H. Bandyopadhyay, L. Hay, I. Iashvili, A. Kharchilava, C. McLean, M. Morris, D. Nguyen, J. Pekkanen, S. Rappoccio, H. Rejeb Sfar, A. Williams, G. Alverson, E. Barberis, Y. Haddad, Y. Han, A. Krishna, J. Li, G. Madigan, B. Marzocchi, D. M. Morse, V. Nguyen, T. Orimoto, A. Parker, L. Skinnari, A. Tishelman-Charny, B. Wang, D. Wood, J. Bueghly, Z. Chen, A. Gilbert, K. A. Hahn, Y. Liu, D. G. Monk, M. H. Schmitt, A. Taliercio, M. Velasco, R. Band, R. Bucci, M. Cremonesi, A. Das, R. Goldouzian, M. Hildreth, K. Hurtado Anampa, C. Jessop, K. Lannon, J. Lawrence, N. Loukas, L. Lutton, J. Mariano, N. Marinelli, I. Mcalister, T. McCauley, C. Mcgrady, K. Mohrman, C. Moore, Y. Musienko, H. Nelson, R. Ruchti, A. Townsend, M. Wayne, H. Yockey, M. Zarucki, L. Zygala, B. Bylsma, M. Carrigan, L. S. Durkin, C. Hill, M. Joyce, A. Lesauvage, M. Nunez Ornelas, K. Wei, B. L. Winer, B. R. Yates, F. M. Addesa, H. Bouchamaoui, P. Das, G. Dezoort, P. Elmer, A. Frankenthal, B. Greenberg, N. Haubrich, S. Higginbotham, G. Kopp, S. Kwan, D. Lange, A. Loeliger, D. Marlow, I. Ojalvo, J. Olsen, D. Stickland, C. Tully, A. S. Bakshi, V. E. Barnes, S. Chandra, R. Chawla, S. Das, A. Gu, L. Gutay, M. Jones, A. W. Jung, D. Kondratyev, A. M. Koshy, M. Liu, G. Negro, N. Neumeister, G. Paspalaki, S. Piperov, A. Purohit, J. F. Schulte, M. Stojanovic, J. Thieman, F. Wang, W. Xie, J. Dolen, N. Parashar, A. Pathak, D. Acosta, A. Baty, T. Carnahan, S. Dildick, K. M. Ecklund, P. J. Fernández Manteca, S. Freed, P. Gardner, F. J. M. Geurts, W. Li, O. Miguel Colin, B. P. Padley, R. Redjimi, J. Rotter, E. Yigitbasi, A. Bodek, P. de Barbaro, R. Demina, J. L. Dulemba, C. Fallon, A. Garcia-Bellido, O. Hindrichs, A. Khukhunaishvili, P. Parygin, E. Popova, R. Taus, G. P. Van Onsem, K. Goulianos, B. Chiarito, J. P. Chou, Y. Gershtein, E. Halkiadakis, A. Hart, M. Heindl, D. Jaroslawski, O. Karacheban, I. Laflotte, A. Lath, R. Montalvo, K. Nash, M. Osherson, H. Routray, S. Salur, S. Schnetzer, S. Somalwar, R. Stone, S. A. Thayil, S. Thomas, J. Vora, H. Wang, H. Acharya, A. G. Delannoy, S. Fiorendi, T. Holmes, N. Karunarathna, L. Lee, E. Nibigira, S. Spanier, M. Ahmad, O. Bouhali, M. Dalchenko, A. Delgado, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, S. Luo, S. Malhotra, R. Mueller, D. Overton, D. Rathjens, A. Safonov, N. Akchurin, J. Damgov, V. Hegde, K. Lamichhane, T. Mengke, S. Muthumuni, T. Peltola, I. Volobouev, A. Whitbeck, E. Appelt, S. Greene, A. Gurrola, W. Johns, R. Kunnawalkam Elayavalli, A. Melo, F. Romeo, P. Sheldon, S. Tuo, J. Velkovska, J. Viinikainen, B. Cardwell, B. Cox, J. Hakala, R. Hirosky, A. Ledovskoy, A. Li, C. Neu, C. E. Perez Lara, P. E. Karchin, A. Aravind, K. Black, T. Bose, S. Dasu, I. De Bruyn, P. Everaerts, C. Galloni, H. He, M. Herndon, A. Herve, C. K. Koraka, A. Lanaro, R. Loveless, J. Madhusudanan Sreekala, A. Mallampalli, A. Mohammadi, G. Parida, D. Pinna, A. Savin, V. Shang, W. H. Smith, D. Teague, H. F. Tsoi, W. Vetens, A. Warden, S. Afanasiev, V. Andreev, Yu. Andreev, T. Aushev, M. Azarkin, A. Babaev, V. Blinov, E. Boos, V. Borshch, D. Budkouski, M. Chadeeva, V. Chekhovsky, M. Danilov, A. Dermenev, T. Dimova, D. Druzhkin, M. Dubinin, L. Dudko, A. Ershov, G. Gavrilov, V. Gavrilov, S. Gninenko, V. Golovtcov, N. Golubev, I. Golutvin, I. Gorbunov, Y. Ivanov, V. Kachanov, L. Kardapoltsev, V. Karjavine, A. Karneyeu, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, V. Klyukhin, O. Kodolova, D. Konstantinov, V. Korenkov, A. Kozyrev, N. Krasnikov, A. Lanev, P. Levchenko, O. Lukina, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, V. Oreshkin, A. Oskin, V. Palichik, V. Perelygin, S. Petrushanko, V. Popov, O. Radchenko, V. Rusinov, M. Savina, V. Savrin, D. Selivanova, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, A. Snigirev, D. Sosnov, V. Sulimov, E. Tcherniaev, A. Terkulov, O. Teryaev, I. Tlisova, A. Toropin, L. Uvarov, A. Uzunian, A. Vorobyev, N. Voytishin, B. S. Yuldashev, A. Zarubin, I. Zhizhin, and A. Zhokin
- Subjects
Hadron-Hadron Scattering ,Jet Physics ,QCD ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
Abstract The inclusive jet cross section is measured as a function of jet transverse momentum p T and rapidity y. The measurement is performed using proton-proton collision data at s $$ \sqrt{s} $$ = 5.02 TeV, recorded by the CMS experiment at the LHC, corresponding to an integrated luminosity of 27.4 pb −1. The jets are reconstructed with the anti-k T algorithm using a distance parameter of R = 0.4, within the rapidity interval |y| < 2, and across the kinematic range 0.06 < p T < 1 TeV. The jet cross section is unfolded from detector to particle level using the determined jet response and resolution. The results are compared to predictions of perturbative quantum chromodynamics, calculated at both next-to-leading order and next-to-next-to-leading order. The predictions are corrected for nonperturbative effects, and presented for a variety of parton distribution functions and choices of the renormalization/factorization scales and the strong coupling α S.
- Published
- 2025
- Full Text
- View/download PDF
29. Tratamiento quirúrgico de las fracturas bifocales ipsilaterales de tibia: un reto para el cirujano
- Author
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A. Ortega-Yago, M. Barrés-Carsí, and A. Balfagón-Ferrer
- Subjects
Ipsilateral fractures ,Tibia fracture ,Traumatology ,Intramedullary rod ,Plate ,Orthopedic surgery ,RD701-811 - Abstract
Resumen: Introducción: La asociación de fracturas ipsilaterales de tibia presenta una baja incidencia, siendo hasta el 3,2% de las fracturas totales de tibia. Actualmente no existe un patrón oro en cuanto al tratamiento quirúrgico idóneo.El objetivo de este estudio es analizar el tratamiento quirúrgico y los resultados radiográficos, funcionales, así como la tasa asociada de complicaciones de las fracturas bifocales de tibia ipsilaterales. Material y métodos: Estudio retrospectivo observacional de 24 pacientes intervenidos de fractura bifocal de tibia ipsilateral en nuestro hospital desde 2010 hasta 2022. Se incluyeron datos demográficos, quirúrgicos y complicaciones durante el seguimiento. Resultados: Los 24 pacientes se clasificaron en grupo 1 cuando presentaban fractura de meseta y tibial distal (25%), grupo 2 con fractura de meseta y diáfisis (33%) y grupo 3 con fractura de diáfisis y tibia distal (42%). Tres pacientes fueron intervenidos mediante un implante y 21 pacientes mediante 2 implantes. El tiempo medio de seguimiento en consultas externas fue de 2 años y medio; 22 pacientes (92%) presentaron al año carga completa y 2 pacientes carga parcial (8%) debido a las secuelas de las fracturas. El tiempo medio de consolidación de la diáfisis fue de 7,75 ± 2 meses, sin observarse diferencias significativas entre el grupo 2 y el grupo 3 (p = 0,06). El tiempo medio de consolidación de la metáfisis fue de 3,50 ± 1,5 meses, sin observarse diferencias significativas entre el grupo 1 y el grupo 2 (p = 0,065); 7 pacientes (30%) tuvieron complicaciones durante el seguimiento. Conclusiones: Las fracturas bifocales de tibia son fracturas infrecuentes que en ocasiones requieren la combinación de varios tipos de osteosíntesis para obtener una reducción adecuada. En nuestra serie las fracturas más frecuentes fueron del tipo 3 (fractura de diáfisis y tibia distal). Cuando la diáfisis tibial estaba implicada se precisó de osteosíntesis combinada mediante clavo intramedular junto con placas y tornillos, obteniéndose unas tasas de consolidación, resultados funcionales a largo plazo y complicaciones similares a los descritos en la literatura. Abstract: Introduction: The association of ipsilateral tibia fractures has a low incidence, being up to 3.2% of total tibia fractures. Currently there is no gold standard regarding the ideal surgical treatment.The objective of this study is to analyze the surgical treatment and the radiographic and functional results, as well as the associated complication rate of ipsilateral bifocal tibia fractures. Material and methods: Retrospective observational study in our hospital from 2010 to 2022 of 24 patients who underwent bifocal fracture of the ipsilateral tibia. Demographic and surgical data and complications during follow-up were included. Results: The 24 patients were classified into group 1 when they presented a fracture of the plateau and distal tibia (25%), group 2 with a fracture of the plateau and diaphysis (33%) and group 3 with a fracture of the diaphysis and distal tibia (42%). 3 patients underwent surgery with 1 implant and 21 patients with 2 implants. The average follow-up time in outpatient clinics was 2 and a half years. At one year, 22 patients (92%) had full weight bearing and 2 patients had partial weight bearing (8%) due to the sequelae of the fractures. The average time for consolidation of the diaphysis was 7.75 ± 2 months, with no significant differences observed between group 2 and group 3 (p = 0.06). The average time for consolidation of the metaphysis was 3.50 ± 1.5 months, with no significant differences observed between group 1 and group 2 (p = 0.065). 7 patients (30%) had complications during follow-up. Conclusions: Bifocal tibia fractures can be treated using a combination of intramedullary nailing and plate osteosynthesis with good long-term results, obtaining an optimal union rate and low complications. In addition, it facilitates the reduction of the fracture, thus facilitating the patient's recovery and obtaining good long-term functional results.
- Published
- 2025
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30. Model-independent search for pair production of new bosons decaying into muons in proton-proton collisions at s $$ \sqrt{s} $$ = 13 TeV
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The CMS collaboration, A. Hayrapetyan, A. Tumasyan, W. Adam, J. W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, P. S. Hussain, M. Jeitler, N. Krammer, A. Li, D. Liko, I. Mikulec, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, M. R. Darwish, T. Janssen, T. Van Laer, P. Van Mechelen, N. Breugelmans, J. D’Hondt, S. Dansana, A. De Moor, M. Delcourt, F. Heyen, S. Lowette, I. Makarenko, D. Müller, S. Tavernier, M. Tytgat, G. P. Van Onsem, S. Van Putte, D. Vannerom, B. Bilin, B. Clerbaux, A. K. Das, G. De Lentdecker, H. Evard, L. Favart, P. Gianneios, J. Jaramillo, A. Khalilzadeh, F. A. Khan, K. Lee, M. Mahdavikhorrami, A. Malara, S. Paredes, M. A. Shahzad, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, M. De Coen, D. Dobur, G. Gokbulut, Y. Hong, J. Knolle, L. Lambrecht, D. Marckx, K. Mota Amarilo, A. Samalan, K. Skovpen, N. Van Den Bossche, J. van der Linden, L. Wezenbeek, A. Benecke, A. Bethani, G. Bruno, C. 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Korenkov, A. Lanev, A. Malakhov, V. Matveev, V. Palichik, V. Perelygin, M. Savina, V. Shalaev, S. Shmatov, S. Shulha, V. Smirnov, O. Teryaev, N. Voytishin, B. S. Yuldashev, A. Zarubin, I. Zhizhin, G. Gavrilov, V. Golovtcov, Y. Ivanov, V. Kim, P. Levchenko, V. Murzin, V. Oreshkin, D. Sosnov, V. Sulimov, L. Uvarov, A. Vorobyev, Yu. Andreev, A. Dermenev, S. Gninenko, N. Golubev, A. Karneyeu, D. Kirpichnikov, M. Kirsanov, N. Krasnikov, I. Tlisova, A. Toropin, T. Aushev, V. Gavrilov, N. Lychkovskaya, A. Nikitenko, V. Popov, A. Zhokin, M. Chadeeva, R. Chistov, S. Polikarpov, V. Andreev, M. Azarkin, M. Kirakosyan, A. Terkulov, E. Boos, V. Bunichev, M. Dubinin, L. Dudko, A. Gribushin, V. Klyukhin, O. Kodolova, S. Obraztsov, M. Perfilov, S. Petrushanko, V. Savrin, G. Vorotnikov, V. Blinov, T. Dimova, A. Kozyrev, O. Radchenko, Y. Skovpen, V. Kachanov, D. Konstantinov, S. Slabospitskii, A. Uzunian, A. Babaev, V. Borshch, D. Druzhkin, V. Chekhovsky, and V. Makarenko
- Subjects
Beyond Standard Model ,Hadron-Hadron Scattering ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
Abstract The results of a model-independent search for the pair production of new bosons within a mass range of 0.21 < m < 60 GeV, are presented. This study utilizes events with a four-muon final state. We use two data sets, comprising 41.5 fb −1 and 59.7 fb −1 of proton-proton collisions at s $$ \sqrt{s} $$ = 13 TeV, recorded in 2017 and 2018 by the CMS experiment at the CERN LHC. The study of the 2018 data set includes a search for displaced signatures of a new boson within the proper decay length range of 0 < cτ < 100 mm. Our results are combined with a previous CMS result, based on 35.9 fb −1 of proton-proton collisions at s $$ \sqrt{s} $$ = 13 TeV collected in 2016. No significant deviation from the expected background is observed. Results are presented in terms of a model-independent upper limit on the product of cross section, branching fraction, and acceptance. The findings are interpreted across various benchmark models, such as an axion-like particle model, a vector portal model, the next-to-minimal supersymmetric standard model, and a dark supersymmetric scenario, including those predicting a non-negligible proper decay length of the new boson. In all considered scenarios, substantial portions of the parameter space are excluded, expanding upon prior results.
- Published
- 2024
- Full Text
- View/download PDF
31. Measurement of boosted Higgs bosons produced via vector boson fusion or gluon fusion in the H → b b ¯ $$ \textrm{b}\overline{\textrm{b}} $$ decay mode using LHC proton-proton collision data at s $$ \sqrt{s} $$ = 13 TeV
- Author
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The CMS collaboration, A. Hayrapetyan, A. Tumasyan, W. Adam, J. W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, P. S. Hussain, M. Jeitler, N. Krammer, A. Li, D. Liko, I. Mikulec, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, M. R. Darwish, T. Janssen, P. Van Mechelen, E. S. Bols, J. D’Hondt, S. Dansana, A. De Moor, M. Delcourt, H. El Faham, S. Lowette, I. Makarenko, D. Müller, S. Tavernier, M. Tytgat, G. P. Van Onsem, S. Van Putte, D. Vannerom, B. Clerbaux, A. K. Das, G. De Lentdecker, H. Evard, L. Favart, P. Gianneios, D. Hohov, J. Jaramillo, A. Khalilzadeh, F. A. Khan, K. Lee, M. Mahdavikhorrami, A. Malara, S. Paredes, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, M. De Coen, D. Dobur, Y. Hong, J. Knolle, L. Lambrecht, G. Mestdach, K. Mota Amarilo, C. Rendón, A. Samalan, K. Skovpen, N. Van Den Bossche, J. van der Linden, L. Wezenbeek, A. Benecke, A. Bethani, G. Bruno, C. Caputo, C. Delaere, I. S. Donertas, A. Giammanco, Sa. Jain, V. Lemaitre, J. Lidrych, P. Mastrapasqua, K. Mondal, T. T. Tran, S. Wertz, G. A. Alves, E. Coelho, C. Hensel, T. Menezes De Oliveira, A. Moraes, P. Rebello Teles, M. Soeiro, W. L. Aldá Júnior, M. Alves Gallo Pereira, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E. M. Da Costa, G. G. Da Silveira, D. De Jesus Damiao, S. Fonseca De Souza, R. Gomes De Souza, J. Martins, C. Mora Herrera, L. Mundim, H. Nogima, J. P. Pinheiro, A. Santoro, A. Sznajder, M. Thiel, A. Vilela Pereira, C. A. Bernardes, L. Calligaris, T. R. Fernandez Perez Tomei, E. M. Gregores, P. G. Mercadante, S. F. Novaes, B. Orzari, Sandra S. Padula, A. Aleksandrov, G. Antchev, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Shopova, G. Sultanov, A. Dimitrov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, S. Keshri, S. Thakur, T. Cheng, T. Javaid, L. Yuan, Z. Hu, J. Liu, K. Yi, G. M. Chen, H. S. Chen, M. Chen, F. Iemmi, C. H. Jiang, A. Kapoor, H. Liao, Z.-A. 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Wichmann, L. Wiens, C. Wissing, Y. Yang, A. Zimermmane Castro Santos, A. Albrecht, S. Albrecht, M. Antonello, S. Bein, L. Benato, S. Bollweg, M. Bonanomi, P. Connor, M. Eich, K. El Morabit, Y. Fischer, C. Garbers, E. Garutti, A. Grohsjean, J. Haller, H. R. Jabusch, G. Kasieczka, P. Keicher, R. Klanner, W. Korcari, T. Kramer, V. Kutzner, F. Labe, J. Lange, A. Lobanov, C. Matthies, A. Mehta, L. Moureaux, M. Mrowietz, A. Nigamova, Y. Nissan, A. Paasch, K. J. Pena Rodriguez, T. Quadfasel, B. Raciti, M. Rieger, D. Savoiu, J. Schindler, P. Schleper, M. Schröder, J. Schwandt, M. Sommerhalder, H. Stadie, G. Steinbrück, A. Tews, M. Wolf, S. Brommer, M. Burkart, E. Butz, T. Chwalek, A. Dierlamm, A. Droll, N. Faltermann, M. Giffels, A. Gottmann, F. Hartmann, R. Hofsaess, M. Horzela, U. Husemann, J. Kieseler, M. Klute, R. Koppenhöfer, J. M. Lawhorn, M. Link, A. Lintuluoto, S. Maier, S. Mitra, M. Mormile, Th. Müller, M. Neukum, M. Oh, E. Pfeffer, M. Presilla, G. Quast, K. Rabbertz, B. Regnery, N. 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Wan, M. Wayne, H. Yockey, M. Zarucki, L. Zygala, A. Basnet, B. Bylsma, M. Carrigan, L. S. Durkin, C. Hill, M. Joyce, M. Nunez Ornelas, K. Wei, B. L. Winer, B. R. Yates, F. M. Addesa, H. Bouchamaoui, P. Das, G. Dezoort, P. Elmer, A. Frankenthal, B. Greenberg, N. Haubrich, G. Kopp, S. Kwan, D. Lange, A. Loeliger, D. Marlow, I. Ojalvo, J. Olsen, A. Shevelev, D. Stickland, C. Tully, A. S. Bakshi, V. E. Barnes, S. Chandra, R. Chawla, A. Gu, L. Gutay, M. Jones, A. W. Jung, D. Kondratyev, A. M. Koshy, M. Liu, G. Negro, N. Neumeister, G. Paspalaki, S. Piperov, V. Scheurer, J. F. Schulte, M. Stojanovic, J. Thieman, A. K. Virdi, F. Wang, W. Xie, J. Dolen, N. Parashar, A. Pathak, D. Acosta, T. Carnahan, K. M. Ecklund, P. J. Fernández Manteca, S. Freed, P. Gardner, F. J. M. Geurts, W. Li, O. Miguel Colin, B. P. Padley, R. Redjimi, J. Rotter, E. Yigitbasi, Y. Zhang, A. Bodek, P. de Barbaro, R. Demina, J. L. Dulemba, A. Garcia-Bellido, O. Hindrichs, A. Khukhunaishvili, N. Parmar, P. Parygin, E. Popova, R. Taus, K. Goulianos, B. Chiarito, J. P. Chou, S. V. Clark, Y. Gershtein, E. Halkiadakis, M. Heindl, C. Houghton, D. Jaroslawski, O. Karacheban, I. Laflotte, A. Lath, R. Montalvo, K. Nash, H. Routray, S. Salur, S. Schnetzer, S. Somalwar, R. Stone, S. A. Thayil, S. Thomas, J. Vora, H. Wang, H. Acharya, D. Ally, A. G. Delannoy, S. Fiorendi, S. Higginbotham, T. Holmes, A. R. Kanuganti, N. Karunarathna, L. Lee, E. Nibigira, S. Spanier, D. Aebi, M. Ahmad, O. Bouhali, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, S. Luo, R. Mueller, D. Overton, D. Rathjens, A. Safonov, N. Akchurin, J. Damgov, V. Hegde, A. Hussain, Y. Kazhykarim, K. Lamichhane, A. Mankel, T. Peltola, I. Volobouev, E. Appelt, Y. Chen, S. Greene, A. Gurrola, W. Johns, R. Kunnawalkam Elayavalli, A. Melo, F. Romeo, P. Sheldon, S. Tuo, J. Velkovska, J. Viinikainen, B. Cardwell, B. Cox, J. Hakala, R. Hirosky, A. Ledovskoy, C. Neu, C. E. Perez Lara, P. E. Karchin, A. Aravind, K. Black, T. Bose, S. Dasu, I. De Bruyn, P. Everaerts, C. Galloni, H. He, M. Herndon, A. Herve, C. K. Koraka, A. Lanaro, R. Loveless, J. Madhusudanan Sreekala, A. Mallampalli, A. Mohammadi, G. Parida, L. Pétré, D. Pinna, A. Savin, V. Shang, W. H. Smith, D. Teague, H. F. Tsoi, W. Vetens, A. Warden, S. Afanasiev, D. Budkouski, I. Golutvin, I. Gorbunov, V. Karjavine, V. Korenkov, A. Lanev, A. Malakhov, V. Matveev, V. Palichik, V. Perelygin, M. Savina, V. Shalaev, S. Shmatov, S. Shulha, V. Smirnov, O. Teryaev, N. Voytishin, B. S. Yuldashev, A. Zarubin, I. Zhizhin, G. Gavrilov, V. Golovtcov, Y. Ivanov, V. Kim, P. Levchenko, V. Murzin, V. Oreshkin, D. Sosnov, V. Sulimov, L. Uvarov, A. Vorobyev, Yu. Andreev, A. Dermenev, S. Gninenko, N. Golubev, A. Karneyeu, D. Kirpichnikov, M. Kirsanov, N. Krasnikov, I. Tlisova, A. Toropin, T. Aushev, V. Gavrilov, N. Lychkovskaya, A. Nikitenko, V. Popov, A. Zhokin, R. Chistov, M. Danilov, S. Polikarpov, V. Andreev, M. Azarkin, M. Kirakosyan, A. Terkulov, E. Boos, V. Bunichev, M. Dubinin, L. Dudko, A. Gribushin, V. Klyukhin, O. Kodolova, S. Obraztsov, M. Perfilov, S. Petrushanko, V. Savrin, G. Vorotnikov, V. Blinov, T. Dimova, A. Kozyrev, O. Radchenko, Y. Skovpen, V. Kachanov, D. Konstantinov, S. Slabospitskii, A. Uzunian, A. Babaev, V. Borshch, D. Druzhkin, E. Tcherniaev, V. Chekhovsky, and V. Makarenko
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Hadron-Hadron Scattering ,Higgs Physics ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
Abstract A measurement is performed of Higgs bosons produced with high transverse momentum (p T) via vector boson or gluon fusion in proton-proton collisions. The result is based on a data set with a center-of-mass energy of 13 TeV collected in 2016–2018 with the CMS detector at the LHC and corresponds to an integrated luminosity of 138 fb −1. The decay of a high-p T Higgs boson to a boosted bottom quark-antiquark pair is selected using large-radius jets and employing jet substructure and heavy-flavor taggers based on machine learning techniques. Independent regions targeting the vector boson and gluon fusion mechanisms are defined based on the topology of two quark-initiated jets with large pseudorapidity separation. The signal strengths for both processes are extracted simultaneously by performing a maximum likelihood fit to data in the large-radius jet mass distribution. The observed signal strengths relative to the standard model expectation are 4.9 − 1.6 + 1.9 $$ {4.9}_{-1.6}^{+1.9} $$ and 1.6 − 1.5 + 1.7 $$ {1.6}_{-1.5}^{+1.7} $$ for the vector boson and gluon fusion mechanisms, respectively. A differential cross section measurement is also reported in the simplified template cross section framework.
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- 2024
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32. Droughts of the early 19th century (1790–1830) in the northeastern Iberian Peninsula: integration of historical and instrumental data for high-resolution reconstructions of extreme events
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J. Barriendos, M. Hernández, S. Gil-Guirado, J. Olcina Cantos, and M. Barriendos
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Environmental pollution ,TD172-193.5 ,Environmental protection ,TD169-171.8 ,Environmental sciences ,GE1-350 - Abstract
Drought represents a prevalent climate risk in the Mediterranean region. In the context of climate change, an increase in both frequency and intensity is anticipated over the next century. In order to effectively manage future scenarios where global warming overlays natural climate variability, a thorough analysis of the nature of droughts prior to the industrial age is crucial. This approach incorporates an extended temporal scale into the study of severe droughts, enabling the identification of low-frequency drought events that occurred before the instrumental period. The objective of this study is to examine the occurrence and magnitude of extreme droughts lasting over a year in the Spanish Mediterranean basin during the early 19th century (1790–1830). To achieve this objective, the research integrates the use of instrumental observations and information derived from historical documentary sources with daily to monthly resolutions (e.g., rogation ceremonies). The findings reveal that drought episodes were more frequent and severe during the early 19th century compared to the late 19th century. Moreover, drought episodes of similar severity were rare throughout the 20th century. Only in the current context of climate change, over the last 2 decades, has a pattern of high drought severity been identified that resembles the severity found during the early 19th century (especially between 1812 and 1825). This study underscores the presence of high variability in drought patterns over the last few centuries, justifying the need for intensified research on drought episodes with high temporal resolution for extended periods.
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- 2024
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33. Crystallization kinetics and thermodynamics of an Ag–In–Sb–Te phase change material using complementary in situ microscopic techniques
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Isak McGieson, Victoriea L. Bird, Christopher M. Barr, Khalid Hattar, Bryan W. Reed, Joseph T. McKeown, Feng Yi, David A. LaVan, and M. K. Santala
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Mechanics of Materials ,Mechanical Engineering ,General Materials Science ,Condensed Matter Physics - Published
- 2022
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34. Characterization of low-grade arthralgia, myalgia, and musculoskeletal pain with ibrutinib therapy: pooled analysis of clinical trials in patients with chronic lymphocytic leukemia and mantle cell lymphoma
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Tanya Siddiqi, Steven Coutre, Matthew McKinney, Paul M. Barr, Kerry Rogers, Ahmad Mokatrin, Rudy Valentino, Anita Szoke, Sanjay Deshpande, Angeline Zhu, Israel Arango-Hisijara, Kojo Osei-Bonsu, Michael Wang, and Susan O’Brien
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Adult ,Cancer Research ,Adenine ,Lymphoma, Mantle-Cell ,Myalgia ,Hematology ,Arthralgia ,Leukemia, Lymphocytic, Chronic, B-Cell ,Pyrimidines ,Piperidines ,Oncology ,Musculoskeletal Pain ,Humans ,Pyrazoles ,Protein Kinase Inhibitors - Abstract
Joint and muscle pain, including arthralgia, myalgia, and musculoskeletal pain, are among the common adverse events (AEs) reported for ibrutinib, a once-daily Bruton's tyrosine kinase inhibitor approved for the treatment of various B-cell malignancies, including chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL). This pooled analysis from nine clinical trials of ibrutinib in CLL and MCL (
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- 2022
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35. Phase 1/2 study of acalabrutinib and the PI3K delta inhibitor ACP-319 in relapsed/refractory B-cell Non-Hodgkin lymphoma
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Paul M. Barr, Stephen D. Smith, Mark J. Roschewski, Susan M. O’Brien, Jeff P. Sharman, Jason M. Melear, Priti Patel, Roser Calvo, Helen Yang, and Stephen E. Spurgeon
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Cancer Research ,Oncology ,Hematology - Published
- 2022
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36. The highly selective Bruton tyrosine kinase inhibitor acalabrutinib leaves macrophage phagocytosis intact
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Jonathan J, Pinney, Sara K, Blick-Nitko, Andrea M, Baran, Derick R, Peterson, Hannah E, Whitehead, Raquel, Izumi, Veerendra, Munugalavadla, Karl R, Van DerMeid, Paul M, Barr, Clive S, Zent, Michael R, Elliott, and Charles C, Chu
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Plant Leaves ,Phagocytosis ,Macrophages ,Pyrazines ,Benzamides ,Humans ,Hematology ,Leukemia, Lymphocytic, Chronic, B-Cell ,Protein Kinase Inhibitors - Published
- 2022
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37. A scoping review of psychiatric conditions associated with chronic pain in the homeless and marginally housed population
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Kathryn Rintoul, Esther Song, Rachel McLellan-Carich, Elizabeth N. R. Schjelderup, and Alasdair M. Barr
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General Medicine - Abstract
The present review sought to examine and summarise the unique experience of concurrent pain and psychiatric conditions, that is often neglected, within the population of homeless individuals. Furthermore, the review examined factors that work to aggravate pain and those that have been shown to improve pain management. Electronic databases (MEDLINE, EMBASE, psycINFO, and Web of Science) and the grey literature (Google Scholar) were searched. Two reviewers independently screened and assessed all literature. The PHO MetaQAT was used to appraise quality of all studies included. Fifty-seven studies were included in this scoping review, with most of the research being based in the United States of America. Several interacting factors were found to exacerbate reported pain, as well as severely affect other crucial aspects of life that correlate directly with health, within the homeless population. Notable factors included drug use as a coping mechanism for pain, as well as opioid use preceding pain; financial issues; transportation problems; stigma; and various psychiatric disorders, such as post-traumatic stress disorder, depression, and anxiety. Important pain management strategies included cannabis use, Accelerated Resolution Therapy for treating trauma, and acupuncture. The homeless population experiences multiple barriers which work to further impact their experience with pain and psychiatric conditions. Psychiatric conditions impact pain experience and can work to intensify already adverse health circumstances of homeless individuals.
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- 2023
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38. Using the Pugh Method to Select a Polymetallic Nodule Vertical Transport System
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Aaron M Barr
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On the sea floor of specific deep ocean environments lie prolific amounts of polymetallic nodules that contain minerals critical to meeting the future energy demands of a growing worldwide population. Polymetallic nodules rich in manganese, nickel, and cobalt spread over millions of square kilometers of abyssal seabed and contain the minerals needed for future energy storage demands. The offshore oil and gas industry seeks to participate in the energy expansion by leveraging its deepwater experience to harvest these nodules. The knowledge and wisdom gained from decades of operating offshore provides significant insight into the development and implementation of the technology needed to address the challenges of deep sea nodule harvesting. The authors describe a design selection tool based on the methods described by Stuart Pugh to select a polymetallic nodule Vertical Transport System. Stuart Pugh, known for his work in product design and development, introduced the Pugh Method in the 1980s. The Pugh Method is a structured and integrated process applied to design development including concept generation, evaluation, and selection. The Vertical Transport System design processes uses the Pugh Method to recommend a candidate design. The evaluation step uses a two groups of company experts who present the concepts (the team), and collectively evaluate (the group) and recommend the best design concept for further development. We apply the method to the case of deep sea mineral recovery operations specifically the design of the Vertical Transportation System. First, the authors introduce the Pugh Method tool, how it works, and how it applies to this specific case. We describe how risks and rewards relate to each selection characteristic used to evaluate the Vertical Transport System concepts. Further, we talk about team selection and the points to consider when assembling the right team to achieve credible results. Next, we describe each concept identifying and recognizing the various technical, operational, and economic selection characteristics, such as size, power consumption, reliability, availability, etc. Finally, we evaluate each concept against the different selection characteristics and discuss the results. The paper concludes with a robust process flow chart describing the selection method for a Vertical Transport System.
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- 2023
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39. Forest and fishing industries
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Brenton M. Barr
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- 2023
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40. Data from Effective Tumor Debulking with Ibrutinib Before Initiation of Venetoclax: Results from the CAPTIVATE Minimal Residual Disease and Fixed-Duration Cohorts
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Constantine S. Tam, Gabriel Krigsfeld, Joi Ninomoto, Cathy Zhou, Patricia Walker, Andrew P. Grigg, Susan O'Brien, Ryan Jacobs, Daniele Vallisa, Paolo Ghia, John N. Allan, William G. Wierda, Alessandra Tedeschi, and Paul M. Barr
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Purpose:The phase II CAPTIVATE study investigated first-line treatment with ibrutinib plus venetoclax for chronic lymphocytic leukemia in two cohorts: minimal residual disease (MRD)-guided randomized treatment discontinuation (MRD cohort) and fixed duration (FD cohort). We report tumor debulking and tumor lysis syndrome (TLS) risk category reduction with three cycles of single-agent ibrutinib lead-in before initiation of venetoclax using pooled data from the MRD and FD cohorts.Patients and Methods:In both cohorts, patients initially received three cycles of ibrutinib 420 mg/day then 12 cycles of ibrutinib plus venetoclax (5-week ramp-up to 400 mg/day).Results:In the total population (N = 323), the following decreases from baseline to after ibrutinib lead-in were observed: percentage of patients with a lymph node diameter ≥5 cm decreased from 31% to 4%, with absolute lymphocyte count ≥25 × 109/L from 76% to 65%, with high tumor burden category for TLS risk from 23% to 2%, and with an indication for hospitalization (high TLS risk, or medium TLS risk and creatinine clearance Conclusions:Three cycles of ibrutinib lead-in before venetoclax initiation provides effective tumor debulking, decreases the TLS risk category and reduces the need for hospitalization for intensive monitoring for TLS.
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- 2023
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41. Supplementary Data from Effective Tumor Debulking with Ibrutinib Before Initiation of Venetoclax: Results from the CAPTIVATE Minimal Residual Disease and Fixed-Duration Cohorts
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Constantine S. Tam, Gabriel Krigsfeld, Joi Ninomoto, Cathy Zhou, Patricia Walker, Andrew P. Grigg, Susan O'Brien, Ryan Jacobs, Daniele Vallisa, Paolo Ghia, John N. Allan, William G. Wierda, Alessandra Tedeschi, and Paul M. Barr
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Supplementary Data from Effective Tumor Debulking with Ibrutinib Before Initiation of Venetoclax: Results from the CAPTIVATE Minimal Residual Disease and Fixed-Duration Cohorts
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- 2023
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42. Supplementary Data from Tumor Lysis, Adverse Events, and Dose Adjustments in 297 Venetoclax-Treated CLL Patients in Routine Clinical Practice
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Anthony R. Mato, Amy A. Kirkwood, Anna Schuh, Neil Bailey, Andrea Sitlinger, Laurie Pearson, Sivraj Muralikrishnan, Andre Goy, Ryan Jacobs, Annalynn M. Williams, John M. Pagel, Charlene Kabel, Hannah Morse, Colleen Dorsey, Joanna Rhodes, Allison M. Winter, Hande H. Tuncer, Chaitra S. Ujjani, Mazyar Shadman, Alan P. Skarbnik, Paul M. Barr, Catherine C. Coombs, Arun K. Singavi, Nicole Lamanna, Bruce D. Cheson, Maryam Yazdy, Frederick Lansigan, Nirav N. Shah, Brian T. Hill, Chadi Nabhan, Stephen J. Schuster, John N. Allan, Danielle M. Brander, Toby A. Eyre, Christopher P. Fox, and Lindsey E. Roeker
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Supplemental Table 1 and Supplemental Figure Legends
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- 2023
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43. Data from Tumor Lysis, Adverse Events, and Dose Adjustments in 297 Venetoclax-Treated CLL Patients in Routine Clinical Practice
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Anthony R. Mato, Amy A. Kirkwood, Anna Schuh, Neil Bailey, Andrea Sitlinger, Laurie Pearson, Sivraj Muralikrishnan, Andre Goy, Ryan Jacobs, Annalynn M. Williams, John M. Pagel, Charlene Kabel, Hannah Morse, Colleen Dorsey, Joanna Rhodes, Allison M. Winter, Hande H. Tuncer, Chaitra S. Ujjani, Mazyar Shadman, Alan P. Skarbnik, Paul M. Barr, Catherine C. Coombs, Arun K. Singavi, Nicole Lamanna, Bruce D. Cheson, Maryam Yazdy, Frederick Lansigan, Nirav N. Shah, Brian T. Hill, Chadi Nabhan, Stephen J. Schuster, John N. Allan, Danielle M. Brander, Toby A. Eyre, Christopher P. Fox, and Lindsey E. Roeker
- Abstract
Purpose:Clinical trials of venetoclax reported negligible rates of clinical tumor lysis syndrome (TLS) in patients with chronic lymphocytic leukemia (CLL) when using an extended dose escalation schedule. We aimed to understand TLS prophylaxis, rates of select adverse events (AE), and impact of dosing modifications in routine clinical practice.Experimental Design:This retrospective cohort study included 297 CLL venetoclax-treated patients outside of clinical trials in academic and community centers. Demographics, baseline disease characteristics, venetoclax dosing, TLS risk and prophylaxis, and AEs were collected.Results:The group was 69% male, 96% had relapsed/refractory CLL, 45% had deletion chromosome 17p, 84% had unmutated IGHV, 80% received venetoclax monotherapy, and median age was 67. TLS risk was categorized as low (40%), intermediate (32%), or high (28%), and 62% had imaging prior to venetoclax initiation. Clinical TLS occurred in 2.7% of patients and laboratory TLS occurred in 5.7%. Pre-venetoclax TLS risk group and creatinine clearance independently predict TLS development in multivariable analysis. Grade 3/4 AEs included neutropenia (39.6%), thrombocytopenia (29.2%), infection (25%), neutropenic fever (7.9%), and diarrhea (6.9%). Twenty-two patients (7.4%) discontinued venetoclax due to an AE. Progression-free survival was similar regardless of number of dose interruptions, length of dose interruption, and stable venetoclax dose.Conclusions:These data provide insights into current use of venetoclax in clinical practice, including TLS rates observed in clinical practice. We identified opportunities for improved adherence to TLS risk stratification and prophylaxis, which may improve safety.
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- 2023
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44. Data from Assessment of the Efficacy of Therapies Following Venetoclax Discontinuation in CLL Reveals BTK Inhibition as an Effective Strategy
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Toby A. Eyre, John N. Allan, Bruce D. Cheson, Kayla Bigelow, Colleen Dorsey, Andrew D. Zelenetz, Amber C. King, Julie M. Goodfriend, Chadi Nabhan, Hanna B. Weissbrot, Jason C. Lee, Neil Bailey, Erica B. Bhavsar, Talha Munir, Nicolas Martinez-Calle, Christopher P. Fox, Thomas D. Rodgers, Stephen J. Schuster, Timothy J. Voorhees, Kentson Lam, Rachael Pocock, Othman S. Akhtar, Pratik Shah, Krista M. Isaac, Ariel F. Grajales-Cruz, Sirin Khajavian, Andrea Sitlinger, Allison M. Winter, Kate J. Whitaker, Christine A. Garcia, Helen Parry, Craig A. Portell, Paul M. Barr, Joanna Rhodes, Catherine C. Coombs, Michael Choi, Bita Fakhri, Satyen Gohil, John M. Pagel, Jeffrey J. Pu, Pallawi Torka, Alan P. Skarbnik, Jacqueline Barrientos, Javier A. Pinilla-Ibarz, Guilherme Fleury Perini, Maryam Sarraf Yazdy, Chaitra S. Ujjani, Mazyar Shadman, Danielle Brander, Nicole Lamanna, Brian T. Hill, Ryan Jacobs, Lindsey E. Roeker, and Anthony R. Mato
- Abstract
Purpose:Venetoclax-based therapy is a standard-of-care option in first-line and relapsed/refractory chronic lymphocytic leukemia (CLL). Patient management following venetoclax discontinuation remains nonstandard and poorly understood.Experimental Design:To address this, we conducted a large international study to identify a cohort of 326 patients who discontinued venetoclax and have been subsequently treated. Coprimary endpoints were overall response rate (ORR) and progression-free survival for the post-venetoclax treatments stratified by treatment type [Bruton's tyrosine kinase inhibitor (BTKi), PI3K inhibitor (PI3Ki), and cellular therapies].Results:We identified patients with CLL who discontinued venetoclax in the first-line (4%) and relapsed/refractory settings (96%). Patients received a median of three therapies prior to venetoclax; 40% were BTKi naïve (n = 130), and 81% were idelalisib naïve (n = 263). ORR to BTKi was 84% (n = 44) in BTKi-naïve patients versus 54% (n = 30) in BTKi-exposed patients. We demonstrate therapy selection following venetoclax requires prior novel agent exposure consideration and discontinuation reasons.Conclusions:For BTKi-naïve patients, selection of covalently binding BTKis results in high ORR and durable remissions. For BTKi-exposed patients, covalent BTK inhibition is not effective in the setting of BTKi resistance. PI3Kis following venetoclax do not appear to result in durable remissions. We conclude that BTKi in naïve or previously responsive patients and cellular therapies following venetoclax may be the most effective strategies.See related commentary by Rogers, p. 3501
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- 2023
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45. Supplemental Figure 2 from Assessment of the Efficacy of Therapies Following Venetoclax Discontinuation in CLL Reveals BTK Inhibition as an Effective Strategy
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Toby A. Eyre, John N. Allan, Bruce D. Cheson, Kayla Bigelow, Colleen Dorsey, Andrew D. Zelenetz, Amber C. King, Julie M. Goodfriend, Chadi Nabhan, Hanna B. Weissbrot, Jason C. Lee, Neil Bailey, Erica B. Bhavsar, Talha Munir, Nicolas Martinez-Calle, Christopher P. Fox, Thomas D. Rodgers, Stephen J. Schuster, Timothy J. Voorhees, Kentson Lam, Rachael Pocock, Othman S. Akhtar, Pratik Shah, Krista M. Isaac, Ariel F. Grajales-Cruz, Sirin Khajavian, Andrea Sitlinger, Allison M. Winter, Kate J. Whitaker, Christine A. Garcia, Helen Parry, Craig A. Portell, Paul M. Barr, Joanna Rhodes, Catherine C. Coombs, Michael Choi, Bita Fakhri, Satyen Gohil, John M. Pagel, Jeffrey J. Pu, Pallawi Torka, Alan P. Skarbnik, Jacqueline Barrientos, Javier A. Pinilla-Ibarz, Guilherme Fleury Perini, Maryam Sarraf Yazdy, Chaitra S. Ujjani, Mazyar Shadman, Danielle Brander, Nicole Lamanna, Brian T. Hill, Ryan Jacobs, Lindsey E. Roeker, and Anthony R. Mato
- Abstract
Supplemental Figure 2: Progression free survival of patients without prior BTKi exposure who had progressed on venetoclax and were then treated with BTKi.
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- 2023
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46. Supplemental Figure 1 from Assessment of the Efficacy of Therapies Following Venetoclax Discontinuation in CLL Reveals BTK Inhibition as an Effective Strategy
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Toby A. Eyre, John N. Allan, Bruce D. Cheson, Kayla Bigelow, Colleen Dorsey, Andrew D. Zelenetz, Amber C. King, Julie M. Goodfriend, Chadi Nabhan, Hanna B. Weissbrot, Jason C. Lee, Neil Bailey, Erica B. Bhavsar, Talha Munir, Nicolas Martinez-Calle, Christopher P. Fox, Thomas D. Rodgers, Stephen J. Schuster, Timothy J. Voorhees, Kentson Lam, Rachael Pocock, Othman S. Akhtar, Pratik Shah, Krista M. Isaac, Ariel F. Grajales-Cruz, Sirin Khajavian, Andrea Sitlinger, Allison M. Winter, Kate J. Whitaker, Christine A. Garcia, Helen Parry, Craig A. Portell, Paul M. Barr, Joanna Rhodes, Catherine C. Coombs, Michael Choi, Bita Fakhri, Satyen Gohil, John M. Pagel, Jeffrey J. Pu, Pallawi Torka, Alan P. Skarbnik, Jacqueline Barrientos, Javier A. Pinilla-Ibarz, Guilherme Fleury Perini, Maryam Sarraf Yazdy, Chaitra S. Ujjani, Mazyar Shadman, Danielle Brander, Nicole Lamanna, Brian T. Hill, Ryan Jacobs, Lindsey E. Roeker, and Anthony R. Mato
- Abstract
Supplemental Figure 1: Overall survival of entire cohort from initiation of venetoclax.
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- 2023
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47. Cannabis use preferences in women with myofascial pelvic pain: A cross-sectional study
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Emily C. Yang, Nicole A. Koenig, Merry Gong, Lori A. Brotto, Alasdair M. Barr, Terry Lee, Paul J. Yong, and Roxana Geoffrion
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Gynaecology ,Reproductive Medicine ,Obstetrics and Gynecology - Abstract
OBJECTIVE: Myofascial tenderness is present in most chronic pelvic pain conditions and causes significant distress to patients. Treatment is challenging and often not curative. Cannabis is often used for self-management of chronic pelvic pain. However, we do not know which concentrations and routes of administration are most acceptable to users. We aimed to investigate patterns and willingness of cannabis product use among both habitual users and non-users with myofascial pelvic pain (MPP), to inform therapeutic development. STUDY DESIGN: We conducted a cross-sectional study of questionnaire responses from female patients with MPP from two tertiary pelvic pain centers. We aimed for a convenience sample of 100 responses with representation from both centers. Inclusion criteria were age over 18 with pelvic floor muscle tenderness on standard gynecologic examination. We collected information on demographics, pelvic pain history, cannabis use status, cannabis use preferences, validated opioid misuse risk assessment, and interest in using gynecologic cannabis products and used descriptive analyses. RESULTS: 77/135 (57 %) questionnaire respondents were cannabis users and 58 (43 %) were non-users. Most users consume cannabis daily, (48.1 %) orally (66.2 %) or by smoking (60.7 %), and rated cannabis as effective at relieving pelvic pain. 37/58 (63.8 %) non-cannabis users responded that they would be willing to use cannabis for pelvic pain. Lack of information and potential adverse effects were the most common reasons for unwillingness to use. Approximately 3 of 4 respondents were willing to try vaginal or vulvar application of cannabis products for pelvic pain. CONCLUSIONS: This cross-sectional study describes cannabis use patterns in MPP patients. Topical vulvar and vaginal cannabis products are of strong interest to both cannabis users and non-users and warrant further research.
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- 2023
48. Treatment Discontinuation Patterns for Patients With Chronic Lymphocytic Leukemia in Real-World Settings: Results From a Multi-Center International Study
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Mazyar Shadman, Beenish S. Manzoor, Kavita Sail, Hande H. Tuncer, John N. Allan, Chaitra Ujjani, Nnadozie Emechebe, Rajesh Kamalakar, Catherine C. Coombs, Lori Leslie, Paul M. Barr, Jennifer R. Brown, Toby A. Eyre, Alexandros Rampotas, Anna Schuh, Nicole Lamanna, Alan Skarbnik, Lindsey E. Roeker, Rajat Bannerji, Barbara Eichhorst, Isabelle Fleury, Matthew S. Davids, Hasan Alhasani, Dingfeng Jiang, Brian T. Hill, Stephen J. Schuster, Danielle M. Brander, Irina Pivneva, Rebecca Burne, Annie Guerin, and Anthony R. Mato
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Cancer Research ,Oncology ,Hematology - Published
- 2023
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49. Petrology and age of the Lepreau River Dyke, southern New Brunswick, Canada: source of the end-Triassic Fundy Group basalts
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Sandra M. Barr, James Gregory McHone, and Fred Jourdan
- Subjects
Basalt ,Group (stratigraphy) ,Geochemistry ,General Earth and Planetary Sciences ,Geology - Abstract
A large dyke of quartz tholeiitic gabbronorite has been mapped for 59 km in southern New Brunswick, Canada, between Lepreau River in the northeast and Indian Island in the southwest. Scattered outcrops occur along a positive aeromagnetic lineament, providing a dyke strike of N42°E overall (segments N30°E to N72°E), dips of 80° to 90°NNW, and widths of 4 to 30 m. A new 40Ar/39Ar plagioclase age of 201.67 ± 0.35 Ma for the Lepreau River Dyke is similar to dates for the massive North Mountain Basalt in the Fundy Basin to the east. The dyke is associated with the Ministers Island and Christmas Cove dykes, which are indistinguishable in chemistry, petrology, and probable age, and we regard them as segments of the same co-magmatic dyke system. In addition, their petrology is similar to that of the basalts of the adjacent Early Mesozoic Fundy and Grand Manan basins. We propose that the Lepreau River and associated dykes were sources for the regional basin basalts, which in turn are part of the Central Atlantic Magmatic Province (CAMP) that overlaps the Triassic–Jurassic boundary and associated mass extinction event.
- Published
- 2022
- Full Text
- View/download PDF
50. COVID-19 in patients with CLL: improved survival outcomes and update on management strategies
- Author
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Lindsey E. Roeker, Toby A. Eyre, Meghan C. Thompson, Nicole Lamanna, Alexander R. Coltoff, Matthew S. Davids, Peter O. Baker, Lori Leslie, Kerry A. Rogers, John N. Allan, Raul Cordoba, Alberto Lopez-Garcia, Darko Antic, John M. Pagel, Nicolas Martinez-Calle, José Antonio García-Marco, Jose-Ángel Hernández-Rivas, Fatima Miras, Catherine C. Coombs, Anders Österborg, Lotta Hansson, Amanda N. Seddon, Javier López Jiménez, Matthew R. Wilson, Dima El-Sharkawi, Daniel Wojenski, Shuo Ma, Talha Munir, Susana Valenciano, Erlene Seymour, Paul M. Barr, Jeffrey Pu, Piers E. M. Patten, Guilherme F. Perini, Scott F. Huntington, Helen Parry, Suchitra Sundaram, Alan Skarbnik, Manali Kamdar, Ryan Jacobs, Harriet Walter, Renata Walewska, Angus Broom, Sonia Lebowitz, Krista M. Isaac, Craig A. Portell, Inhye E. Ahn, Chaitra S. Ujjani, Mazyar Shadman, Sigrid S. Skånland, Elise A. Chong, and Anthony R. Mato
- Subjects
Adult ,Male ,medicine.medical_specialty ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Immunology ,MEDLINE ,Improved survival ,Antiviral Agents ,Biochemistry ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,In patient ,Aged ,Retrospective Studies ,Aged, 80 and over ,Lymphoid Neoplasia ,SARS-CoV-2 ,business.industry ,COVID-19 ,Disease Management ,Cell Biology ,Hematology ,Middle Aged ,Prognosis ,Leukemia, Lymphocytic, Chronic, B-Cell ,United States ,Survival Rate ,Drug Therapy, Combination ,Female ,business ,Follow-Up Studies - Published
- 2021
- Full Text
- View/download PDF
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