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2. Improving the Efficiency of Inferences From Hybrid Samples for Effective Health Surveillance Surveys: Comprehensive Review of Quantitative Methods

Author

Mansour Fahimi, Elizabeth C Hair, Elizabeth K Do, Jennifer M Kreslake, Xiaolu Yan, Elisa Chan, Frances M Barlas, Abigail Giles, and Larry Osborn

Subjects
Public aspects of medicine, RA1-1270
Abstract

BackgroundIncreasingly, survey researchers rely on hybrid samples to improve coverage and increase the number of respondents by combining independent samples. For instance, it is possible to combine 2 probability samples with one relying on telephone and another on mail. More commonly, however, researchers are now supplementing probability samples with those from online panels that are less costly. Setting aside ad hoc approaches that are void of rigor, traditionally, the method of composite estimation has been used to blend results from different sample surveys. This means individual point estimates from different surveys are pooled together, 1 estimate at a time. Given that for a typical study many estimates must be produced, this piecemeal approach is computationally burdensome and subject to the inferential limitations of the individual surveys that are used in this process. ObjectiveIn this paper, we will provide a comprehensive review of the traditional method of composite estimation. Subsequently, the method of composite weighting is introduced, which is significantly more efficient, both computationally and inferentially when pooling data from multiple surveys. With the growing interest in hybrid sampling alternatives, we hope to offer an accessible methodology for improving the efficiency of inferences from such sample surveys without sacrificing rigor. MethodsSpecifically, we will illustrate why the many ad hoc procedures for blending survey data from multiple surveys are void of scientific integrity and subject to misleading inferences. Moreover, we will demonstrate how the traditional approach of composite estimation fails to offer a pragmatic and scalable solution in practice. By relying on theoretical and empirical justifications, in contrast, we will show how our proposed methodology of composite weighting is both scientifically sound and inferentially and computationally superior to the old method of composite estimation. ResultsUsing data from 3 large surveys that have relied on hybrid samples composed of probability-based and supplemental sample components from online panels, we illustrate that our proposed method of composite weighting is superior to the traditional method of composite estimation in 2 distinct ways. Computationally, it is vastly less demanding and hence more accessible for practitioners. Inferentially, it produces more efficient estimates with higher levels of external validity when pooling data from multiple surveys. ConclusionsThe new realities of the digital age have brought about a number of resilient challenges for survey researchers, which in turn have exposed some of the inefficiencies associated with the traditional methods this community has relied upon for decades. The resilience of such challenges suggests that piecemeal approaches that may have limited applicability or restricted accessibility will prove to be inadequate and transient. It is from this perspective that our proposed method of composite weighting has aimed to introduce a durable and accessible solution for hybrid sample surveys.

Published
2024
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4. How Effective Are Emojis In Surveys Taken on Mobile Devices?

Author

Randall K. Thomas, Christopher Bacon, Frances M. Barlas, and Zoe Dowling

Subjects
Marketing, Mobile survey, Communication, Data quality, 0502 economics and business, 05 social sciences, 050211 marketing, Business, Compound annual growth rate, Investment (macroeconomics), Mobile device, 050203 business & management
Abstract

In 2016, marketers spent $13.7 billion globally on online consumer research.[1][1] This investment reflected a compound annual growth rate of 6 percent since 2011. At the same time, consumers increasingly were taking online surveys using their smartphones. During the five-year period through 2016

Published
2017
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5. Interface properties of Al–Al2O3–Ge MIS capacitors and the effect of forming gas annealing

Author

A. Karageorgiou, Vassilios Ioannou-Sougleridis, M. Barlas, Spyridon Ladas, and Dimitrios Skarlatos

Subjects
Materials science, Passivation, Annealing (metallurgy), Analytical chemistry, 02 engineering and technology, Dielectric, 01 natural sciences, law.invention, law, 0103 physical sciences, Radiation damage, Electrical and Electronic Engineering, 010302 applied physics, business.industry, Dangling bond, Conductance, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Atomic and Molecular Physics, and Optics, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Capacitor, Optoelectronics, 0210 nano-technology, business, Forming gas
Abstract

In this work the effect of Al deposition process and the subsequent forming gas annealing on the interfacial properties of Al/Al2O3/p-Ge MOS capacitors is studied. Al2O3 has been deposited by ALD at 300°C. There is evidence that Al deposition by e-beam evaporation affects the structure and composition of the Al2O3/Ge interface by decomposing the GeOx interfacial layer and leading to interfacial non-uniformities reflected in conductance measurements. Forming gas annealing is able to passivate interface traps near the valence band edge possibly originating from Al2O3-Ge dangling bonds during the dielectric deposition. However it is unable to passivate interface traps near the midgap possibly originating from e-beam evaporation radiation damage. Display Omitted Study of hydrogen annealing in p-type Ge/Al2O3/Al capacitorsConductance technique at low temperaturesSignificant passivation of interface traps near the valence band edge.

Published
2016
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8. Scientific Surveys Based on Incomplete Sampling Frames and High Rates of Nonresponse

Author

Mansour Fahimi, Randall K. Thomas, Frances M. Barlas, and Nicole Buttermore

Subjects
High rate, Nonprobability sampling, Statistics, Econometrics, Survey sampling, Sampling (statistics), Sample (statistics), Survey research, Sampling frame, Weighting, Mathematics
Abstract

Traditional methods of survey research that rely on Neyman’s probability-based sampling paradigm are grounded in a number of fundamental assumptions that are becoming exceedingly difficult to attain in today’s survey research environment. On the one hand, common methods of sampling are subject to coverage issues that may not be fully ameliorated through post-survey weighting adjustments. On the other, response rates continue to deteriorate for all surveys, even when resource-intensive refusal conversion strategies are employed. Add in the growing need for cost containments and it is no wonder why alternative sampling methods are gaining popularity. The authors will review a number of practices that are currently used for developing inferences from samples that do not fully adhere to the statistical machinery that is currently available for probability-based sample surveys. Moreover, a robust weighting methodology will be introduced that can reduce the inherent biases associated with non-probability samples, as well as probability-based sample surveys that suffer from incomplete frames and high rates of nonresponse. The efficacy of the proposed methodology is assessed in light of comparisons of survey estimates to external benchmarks, relying on parallel surveys that were conducted in two states using both probability-based and non-probability samples.

Published
2015
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9. Improvement of HfO2 based RRAM array performances by local Si implantation

Author

B. Traore, F. Perrin, L. Perniola, Emmanuel Nolot, E. Vianello, Nicolas Vaxelaire, F. Mazen, J. Coignus, Alessandro Grossi, P. Blaise, L. Lachal, S. Bernasconi, S. Pauliac, E. Nowak, S. Chevalliez, J. F. Nodin, R. Crochemore, L. Grenouillet, M. Barlas, and C. Pellissier

Subjects
010302 applied physics, Materials science, Silicon, business.industry, chemistry.chemical_element, 02 engineering and technology, 021001 nanoscience & nanotechnology, 01 natural sciences, Resistive random-access memory, Ion implantation, chemistry, Robustness (computer science), 0103 physical sciences, Memory window, Optoelectronics, Data retention, 0210 nano-technology, business, Low voltage, Voltage
Abstract

A thorough insight of Si implantation in HfU2-based OXRAM is presented, from a material standpoint up to a 4 kbit 1T-1R array. We demonstrate for the first time that local implantation enables switching area localization and significantly decreases forming, set and reset voltages, improves data retention (tails at 3o are stable up to 1000 min at 165°C), while not being detrimental for endurance. In particular using low voltage programming conditions (VF < 3V with 100 ns pulses), a memory window of 10 at 3σ is demonstrated, paving the way to low power OxRAM arrays with lower variability and improved robustness.

Published
2017
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10. OxRAM integration above FDSOI transistor drain: Integration approach and process impact on electrical characteristics

Author

V. Loup, G. Audoit, S. Reboh, R. Coquand, M. Vinet, M. Barlas, N. Rambal, S Barraud, A. Toffoli, E. Vianello, C. Jahan, V. Beugin, Vincent Delaye, O. Pollet, L. Brevard, C. Vizioz, O. Faynot, T. Dewolf, Nicolas Posseme, S. Chevalliez, N. Allouti, L. Perniola, Sébastien Barnola, B. Bouix, S. Bernasconi, C. Comboroure, Philippe Rodriguez, Yves Morand, C. Tallaron, and L. Grenouillet

Subjects
Materials science, law, Process (engineering), Transistor, Engineering physics, law.invention
Published
2017
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11. 142 Keratinocyte p38α ablation reveals a context-dependent regulation of tumor initiation, tumor type specification, maintenance, and malignant progression in several models of mouse skin tumorigenesis

Author

Mary Klosterman, Christophe Cataisson, Stuart H. Yuspa, M. Sall, M. Kellett, Tatiana Efimova, Maria I. Morasso, Alexi Kiss, M. Barlas, and Aaron C. Koppel

Subjects
business.industry, medicine.medical_treatment, Context (language use), Cell Biology, Dermatology, Tumor initiation, medicine.disease_cause, Ablation, Biochemistry, medicine.anatomical_structure, Mouse skin, medicine, Cancer research, Tumor type, Malignant progression, Carcinogenesis, business, Keratinocyte, Molecular Biology
Published
2019
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12. 2011 Health Related Behaviors Survey of Active Duty Military Personnel

Author

Frances M Barlas, Kelly Diecker, Jacqueline C. Pflieger, and William Bryan Higgins

Subjects
Active duty, business.industry, media_common.quotation_subject, medicine.disease, Mental health, Substance abuse, Navy, Military personnel, Physical abuse, Software deployment, Environmental health, medicine, Psychological resilience, business, media_common
Abstract

The 2011 Health Related Behaviors Survey of Active Duty Military Personnel (HRB) is the largest survey that anonymously gathers data on some of the most important behavioral health issues affecting the well-being of the U.S. military. The HRB provides an assessment of issues such as substance use and abuse, stress, posttraumatic stress symptoms, depressive symptoms, possible traumatic brain injury, resilience, sexual and physical abuse history, and deployment-related outcomes from a representative sample of active duty members in each branch of the Department of Defense (DoD) services - the Army, Navy, Marine Corps, and Air Force as well as the United States Coast Guard (USCG), herein collectively referred to as the Armed Forces. The anonymous nature of the survey, coupled with the statistically-valid selection of a representative sample of service members, enables the Armed Forces to measure the prevalence rates of health behaviors. While DoD, each of the DoD Services, and USCG collect administrative data on the outcomes or consequences of maladaptive health behaviors (e.g., number referred to substance abuse treatment), these administrative data often represent a small fraction of the problem, and underscore the need for self-reported measurement of the prevalence rates of these behaviors. The HRB survey ascertains estimates (+/- a small margin of error) of the prevalence of these behaviors, and as a result, provides the Armed Forces a data source that complements, but cannot be duplicated with, administrative records. The data collected over the past 30 years of this survey have been used by military leadership at all levels to make important policy and programmatic changes. Since its inception, the HRB survey has had a substantial impact on the military health field.

Published
2013
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13. Fourth meeting of the European Neurological Society 25–29 June 1994 Barcelona, Spain

Author

H. Hattig, C. Delli Pizzi, M. C. Addonizio, Michelle Davis, A. R. Giovagnoli, L. Florensa, M. Roth, J. de Kruijk, Francisco Lacruz, Ph. Dewailly, A. Toygar, C. Avendano, P.P. De Deyn, J. F. Hurtevent, F. Lomeila, T. W. Wong, Gordon T. Plant, M. Bud, H. J. Willison, DH Miller, D. W. Langdon, R. Cioni, J. Servan, A. Kaygisiz, E. Racadot, D. B. Schens, E. Picciola, L. Falip, C. Bouchard, J. Jotova, A. Jorge-Santamaria, P. Misra, A. Dufour, C. P. Panagopoulos, A. Venneri, B. Sredni, B. Angelard, M. Janelidze, M. Carreno, J. Obenberger, J. Pouget, H. W. Moser, R. Kaufmann, J. A. Molina, D. Linden, A. Martin Urda, E. Uvestad, A. Krone, J. P. Cochin, J. Mallecourt, A. Cambon-Thomsen, K. Violleau, P. Osschmann, A. M. Durocher, E. Bussaglia, D. M. Danielle, H. Efendi, C. Van Broeckhoven, K. G. Jordan, W. Rautenberg, C. Iniguez, J. M. Delgado, Graham Watson, M. Lawden, Gareth J. Barker, K. Stiasny, James T. Becker, G. Campanella, E. Peghi, A. Poli, A. Haddad, T. Yamawaki, Giacomo P. Comi, S. Sotgiu, B. Ersmark, A. Pomes, M. Ziegler, P. Ferrante, P. Ruppi, H. KuÇukoglu, R. Bouton, U. K. Rinne, P. Vieregge, M. Dary, P. Giunti, Peter J. Goadsby, S. Jung, E. Secor, A. Steinberg, N. Vila, M. A. Hernandez, M. Cursi, A. Enqelhardt, A. Engelhardt, J. Veitch, F. Di Silverio, F. Arnaud, B. Neundörfer, R. Brucher, Dominique Caparros-Lefebvre, B. Meyer, Marianne Dieterich, M. H. Snidaro, R. Gomez, R. Cerbo, M. Ragno, J. M. Vance, S. Nemni, A. Caliskan, F. Barros, I. Velcheva, D. Ceballos-Baumann, V. Barak, A. Avila, N. Antonova, F. Resche, S. Pappata, L. Varela, S. R. Silveira Santos, A. Cammarota, L. Naccache, Y. Nara, E. Tournier-Lasserves, R. Mobner, T. Chase, A. Ensenyat, J. Ulrich, G. Giegerich, M. Rother, M. Revilla, N. Nitschke, K. Honczarenko, E. Basart Tarrats, J. Blin, B. Jacob, J. Santamaria, S. Knezevic, J. L. Castillo, M. Antem, J. Colomer, O. Busse, Didier Hannequin, S. Carrier, J. B. Ruidavets, C. Rozman, J. Bogoussslavsky, J. Pascual Calvet, E. Monros, J. M. Polo, M. Zucconl, Javier Muruzabal, R. R. Allen, R. Rivolta, K. Haugaard, A. Nespolo, K. Hoang-Xuang, G. Bussone, T. Avramidis, E. Corsini, Christiana Franke, T. Vinogradova, H. Boot, K. Vestergaard, G. H. Jansen, N. Argentino, M. Raltzig, W. Linssen, Mark B. Pepys, P. Roblot, L. Lauritzen, E. Fainardi, D. Morin, T. X. Arbizu Urdiain, J. Wollenhaupt, S. Bostantjopoulou, G. Pavesi, A. D. Forman, Giovanni Fabbrini, D. Jean, J. J. Archelos, M. I. Blanchs, M. Del Gobbo, Anna Carla Turconi, Ch. Derouesné, Elio Scarpini, A. Visbeck, P. Castejon, J. P. Renou, F. Mounier-Vehier, G. Potagas, Ch. Duyckaerts, A. Filla, R. Schneider, G. Ronen, K. Nagata, J. P. Vedel, A. Henneberg, G. van Melle, C. Baratti, H. Knott, M. C. Prevett, A. Bes, B. Metin, Jos V. Reempts, L. Martorell, Mefkure Eraksoy, H. O. Handwerker, D. S. Younger, O. Oktem, D. Frongillo, C. Soriano-Soriano, L. Niehaus, F. Zipp, A. Tartaro, S Newman, R. H. Browne, P. Davous, R. Sanchez, M. Muros, M. E. Kornhuber, A. Lavarone, M. Mohr, M. R. Garcia, S. Russell, H. Kellar-Wood, M. R. Tola, B. Ostermeyer, Ch. Tzekov, K. Sartor, E. B. Ringelstein, P. P. Gazzaniga, Paul Krack, H. Fidaner, H. Rico, T. Dbaiss, F. Alameda, E. Torchiana, L. Rumbach, I. Charques, J. M. Bogaard, C. D. Frith, L. J. Rappelle, R. Brenner, A. Joutel, K. Fuxe, G. HÄcker, M. J. Blaser, J. Valls-SolÇ, G. Ulm, M. Alberdi, A. Bock, F. W. Bertelsmann, U. Wieshmann, J. Visa, J. R. Lupski, D. D'Amico, L. M. P. Ramos, A. A. Vanderbark, R. Horn, M. Warmuth, Dietmar Kühne, Mark S. Palmer, C. Ehrenheim, E. Canga, S. Viola, O. Scarpino, P. Naldi, R. Almeida, A. A. Raymond, J. Gamez, Stephan Arnold, A. DiGiovanni, J. Dalmau, C. C. Chari, H. F. Beer, J. C. Koetsier, J. Iriarte, E. Yunis, J. Casadevall, E. Le Guern, E. Stenager, S. R. Benbadis, J. M. Warter, F. Burklin, I. Theodorou, L. Johannesen, G. A. Graveland, X. Leclerc, I. Vecchio, L. Ozelius, G. Nicoletti, R. K. Gherardi, E. Esperet, M. L. Delodovici, F. Cattin, F. Paiau, Giorgio Sacilotto, C. A. J. Broere, D. Chavdarov, J. P. Willmer, C. H. Hawkes, Th. Naegele, E. Ellie, E. Dartigues, M. J. Guardiola, S. Hesse, Z. Levic, Marco Rovaris, P. Saugeir-Veber, B. A. Yaqub, H. F. Durwen, R. Larumbe, J. Ballabrina, M. Sendtner, J. Röther, M. Horstink, C. Kluglein, M.P. Montesi, H. Apaydin, J. Montoya, E. Waubant, Ch. Verellen-Dunoulin, A. Nicolai, J. Lopez-Delval, R. Lemon, G. Cantinho, E. Granieri, A. Zeviani, Wolfgang H. Oertel, U. Ficola, V. Di Piero, V. Fragola, K. Sabev, M. V. Guitera, I. Turki, F. Bolgert, P. Ingrand, J. M. Gobernado, L. M. E. Grimaldi, S. Baybas, B. Eymard, Y. Rolland, Y. Robitaille, Ta. Pampols, P. J. Koehler, A. Carroacedo, J. Vilchez, S. Di Vittorio, I. R. Rise, T. Nagy, M. Kuffner, E. Palazzini, A. Ott, J. Pruim, T. X. Arbizu, E. Manetti, C. Cervera, S. Felber, G. Gursoy, J. Scholz, G. A. Buscaino, M. S. Chen, A. Pascual, J. Hazan, J. U. Gajda, J. G. Cea, G. Bottini, G. Damalik, F. Le Doze, G. Bonaldi, J. M. Hew, C. Messina, A. M. Kennedy, J. M. Carney, N. M. F. Murray, M. Parent, M. Koepp, V. Dimova, D. De Leo, K. Jellinger, G. Salemi, S. Mientus, M. L. Hansen, F. Mazzucchelli, J. Vieth, M. Mauri, E. Bartels, L. Johannsen, C. Humphreys, J. Emile, D. N. Landon, E. Kansu, R. Sanchez-Pernaute, Rsj Frackowiak, M. Gonzalez Torres, L. Oller, C. Machedo, J. Kother, M. Billiard, H. Durak, T. Schindler, A. Frank, A. Uncini, A. Sbriccoli, C. Farinas, D. W. Paty, N. Fast, A. T. Zangaladze, A. Kerkhofs, J. M. Pino Garcia, I. De la Fuente, B. Marini, L. Gomez, I. Rubio, Alessandra Bardoni, C. Brodie, P. Acin, U. Sliwka, S. A. Hawkins, S. Tardieu, F. Vitullo, J. M. Pereira Monteino, R. Gagliardi, T. Jezewski, A. Cano, T. Lempert, F. Abad Alegria, G. Rotondo, D. Ince, C. Martinez Parra, Y. Huang, H. Luders, Y. Steinvil, F. G. A. Van Der Meche, R. Bianchi, A. Sanchez, T. Sevilla, J. M. Ketelslegers, A. Domzal-Stryga, M. Pandolfo, M. O. Josse, K. W. Neff, I. Blanco, G. W. Bruyn, O. W. Witte, J. L. Thibault, G. Andersen, J. Pariset, A. Marcone, R. J. M. Lane, A. Hofman, M. Verin, T. Matilla, P. Bedoucha, J. Roche, M. Lai, M. Collard, A. Ugarte, F. Gallecho, D. Silbersweig, C. Kennard, J. P. Azulay, T. W. Ho, P. L. I. Dellemijn, R. Girardello, F. Baas, B. Voss, F. Rozenberg, E. M. Brocker, V. Stanev, A. A. J. Soeterboek, A. Marra, A. Rey, E. Ertem, M. Sawradewicz-Rybak, J. De Keyser, P. Cavallari, F. Proust, Y. Chevalier, H. C. Hansen, D. Leys, C. A. Davie, K. Hoang-Xuan, C. Bairati, H. van Crevel, Thomas T. Warner, B. Bompais, A. Dobbeleir, T Campbell, C. Macko, C. J. M. Klijn, M. Dussallant, T. P. Berlit, W. Rozenbaum, M. J. van den Bent, W. A. Rocca, M. Muller, H. Hundemer, U. Zifko, M. Campera, F. Drislane, D. Ranoux, T. M. Kloss, Anil Kumar, I. Ruolt, C. Bargnani, B. Marescau, N. A. Losseff, S. Notermans, B. Kint, E. T. Burke, C. Aykut, J. Matias Guiu, P. Maquet, T. Drogendijk, M. Leone, K. von Ammon, M. Pepeliarska, C. Prados, L. DiGiamberardino, T. Logtenberg, G. Lenoir, I. Castaldo, Damhaut, M. Radionova, G. Sirabian, R. Navon, Giovanni Antonini, K. Al Moutaery, E. Chamas, R. Schönhuber, M. Giannini, B. Debilly, I. Labatut, H. Henon, J. A. Egido, M. Baudrimont, J. N. Lorenzo, J. E. C. Bromberg, R. Antonacci, J. J. Vilchez, T. Moulin, B. Rautenstrauss, Giovanni Meola, J. Noth, S Mammi, P. Laforet, F. Lopez, C. Gehring, S. Bort, G. Rancurel, D. Decamps, S. Kostadinova, Y. Shapira, B. Neundoerfer, D. Chavrot, M. Solimena, J. P. Salier, W. Deberdt, R. Hoff-Jörgensen, A. Messina, S. Meairs, G. Rosoklija, E. Nelis, I. Bertran, C. Ertekin, J. Lohmeyer, Mitermayer Galvao dos Reis, L. Calo, E. Maccagnano, A. P. Hays, J. Verlooy, M. G. Forno, T. Blanco, L. Bail, Gabriella Silvestri, J. Montero, F. Bertrand, R. T. Ghnassia, C. Besses, T. Sereghy, F. Shalit, G. Bogliun, S. Braghi, St. Baykouchev, C. Franke, A. Lasa, L. C. Archard, J. Kriebel, S. Shaunak, M. Nocito, Alexander Tsiskaridze, E. Manfredini, T. Seigal, David G. Gadian, M. Barlas, J. D. Degos, C. Seeber, J. Caemert, J. L. Mas, R. B. Pepinsky, M. G. D'Angelo, N. Baumann, S. Yorifuji, H. P. Endtz, M. A. Cassatella, R. A. C. Hughes, V. Golzi, A. Bittencourt, A. Ferreira, M. Sanson, C. Alper, M. Vermeulen, M. A. A. van Walderveen, E. Alexiou, C. H. Lucas, M. Fiorelli, Y. N. Debbink, R. Gil, S. Congia, T. Banerjee, J. M. Bouchard, A. N. Pinto, A. Ceballos-Baumann, G. Grollier, P. I. M. Schmitz, M. D. Catata, N. Lahat, N. S. Rao, P. Papathanasopoulos, J. Valls-Solé, D. Claus, G. Schroter, A. Castro, C. Videbaek, R. Martinez Dreke, A. D. Platts, M. Hermesl, A. C. PeÇanha-Martins, M. Cardoso Silva, P. Masnou, M. J. A. Tanner, Ch. Confavreux, B. Mishu, H. Rasmussen, L. Valenciano, Carlo Pozzilli, S. W. Li, V. Salzman, Y. Vashtang, Massimo Franceschi, M. Severo, G. Deuschl, S. Setien, G. Mariani, A. Protti, J. Castillo, M. J. B. Taphoorn, M. Frontali, I. Milonas, D. Decoq, J. A. Navarro, S. Castellvi-Pel, C. Ertikin, M. Urtasun, Y. Lajat, B. E. Kendall, E. Verdu, B. Gueguen, E. Boisen, R. Couderc, A Danek, JM Stevens, F. Nicoli, L. Feltri, M. L. Vazquez-Andre, J. A. Morgan-Hughes, L. D'Angelo, F. Y. Liew, L. F. Pascual, J. Patrignani Ochoa, Vittorio Martinelli, J. Cophignon, L. Zhang, S. Martin, J. F. Meder, H. C. Buschmann, L. Bertin, J. van Gijn, A. Barreiro, A. Cools, C. Leon, A. Berod, E. A. Anllo, E. Zanette, L. Petrov, R. Barona, B. Gallicchio, P. J. Cozzone, N. Diederich, G. Cancel, L. Schelosky, P. Orizaola, K. Yulug, S. Ozer, Valeria A. Sansone, B. Guiraud-Chaumeil, K. Voigt, P. Labauge, M. Eoli, J. Zhu, J. Aguirre, M. Ferrarini, B. Zyluk, E. Planas, A. Cadilha, C. Tortorella, H. Bismuth, C. E. Counsell, A. Laun, A. Ferlini, Rio J. Montalban, N. Biary, L. Becker, M. Fardeau, M. Poloni, V. M. S. de Bruin, C. Fornada, J. Barros, E. Ganzmann, E. Touze, D. Wallach, J. Peila, H. Fujimura, M. T. Iba-Zizen, G. Macchi, C. Villoslada, R. Gouider, Ph. Rondepierre, P. Grummich, P. Chiodi, C. Conte, M. Michels, P. Annunziata, G. Semana, C. Sommer, J. Vajsar, D. Zekin, J. Kulisevsky, David G. Munoz, B. Jacotot, M. Magoni, A. Luxen, T. Garcia-Silva, S. Di Cesare, Christophe Tzourio, M. Gomori, I. Picomell, L. Santoro, F. Villa, Giovanni Pennisi, T. Ribalta, J. M. Molto, L. Marzorati, P. Loiseau, F. Gemignani, A. Gironell, J. Wissel, A. Prusinski, F. Cailloux, P. Villanueva-Hemandez, P. Cozzone, T. Del Ser, J. Sans-Sabrafen, M. Zappia, P. W. A. Willems, G. Tchernia, D. Gardeur, R. Bauer, F. Palomo, H. Metz, S. Lamoureux, C. Chastang, I. Reinhard, A. Goldfarb, S. Harder, Jordi Río, C. Ozkara, E. Tekinsoy, P. Vontobell, J. De Recondo, M. Rabasa, L. Lacomblez, F. Boon, Dgt Thomas, V. Palma, Renato Mantegazza, A. Dervis, M. Nueckel, B. YalÇinerner, I. Duran, G. Dalla Volta, A. Zubimendi, J. Pinheiro, A. Marbini, Xavier Montalban, H. Wekerle, X. Pereira Monteino, F. Crespo, F. Koskas, N. Battistini, C. Ruiz, H. Offner, J. de Pommery, P. Kanovsky, J. Y. Barnett, J. Pardo, G. Tomei, R. Rene, H. M. Lokhorst, P. Thajeb, H. Bilgin, D. McGehee, R. Fahsold, L. Morgante, Katie Sidle, C. Delwaide, M. N. 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Riva, M. H. Mahagne, M. Ozturk, Ve. Drory, N. Konic, C. Jungreis, A. Pou Serradell, J. L. Gauvrit, G. J. Chelune, S. Hermandez, T. Dingus, L. Hewer, Ch. Koch, M. N. Metz-Lutz, G. Parlato, M. Sinaki, Charles Pierrot-Deseilligny, H. C. Diener, J. Broeckx, J. Weill-Fulazza, M. L. Villar, M. Rizzo, O. Ganslandt, C. Duran, N. A. Fletcher, G. Di Giovacchino, Susan T. Iannaccone, C. Kolig, N. Fabre, H. A. Crockard, Rita Bella, M. Tazir, E. Papagiannuli, K. Overgaard, Emma Ciafaloni, I. Lorenzetti, F. Viader, P. A. H. Millac, I. Montiel, L. H. Visser, M. Palomar, P. L. Murgia, H. Pedersen, Rafael Blesa, S. Seddigh, W. O. Renier, I. Lemahieu, H. M. L. Jansen, L. Rosin, J. Galofre, K. Mattos, M. Pondal, G. M. Hadjigeorgiou, D. Francis, L. Cantin, D. Stegeman, M. Rango, A. B. M. F. Karim, S. Schraff, B. Castellotti, I. Iriarte, E. Laborde, T. J. Tjan, R. Mutani, D. Toni, B. Bergaasco, J. G. Young, C. Klotzsch, A. Zincone, X. Ducrocq, M. Uchuya, O. J. Kolar, A. Quattrone, T. Bauermann, Nereo Bresolin, J. Vallée, B. C. Jacobs, A. Campos, Werner Poewe, J. A. Villanueva, A. W. Kornhuber, A. Malafosse, E. Diez-Tejedor, G. Jungreia, M. J. A. Puchner, A. Komiyama, O. Saribas, V. Volpini, L. Geremia, S. Bressi, A. Nibbio, Timothy E. Bates, T. z. Tzonev, E. Ideman, G. A. Damlacik, G. Martino, G. Crepaldi, T. Martino, Kjell Någren, E. Idiman, D. Samuel, J. M. Perez Trullen, Y. van der Graaf, J. O. Thorell, M. J. M. Dupuis, E. Sieber, R. D'Alessandro, C. Cazzaniga, J. Faiss, A. Tanguy, A. Schick, I. Hoksergen, A. Cardozo, R. Shakarishvili, G. K. Wennlng, J. L. Marti-Vilalta, J. Weissenbach, I. L. Simone, Amalia C. Bruni, Darius J. Adams, C. Weiller, A. Pietrangeli, F. Croria, C. Vigo-Pelfrey, Patricia Limousin, A. Ducros, G. Conti, O. Lindvall, E. Richter, M. Zuffi, A. Nappo, T. Riise, J. Wijdenes, M. J. Fernandez, J. Rosell, P. Vermersh, S. Servidei, M. S. C. Verdugo, F. Gouttiere, W. Solbach, M. Malbezin, I. S. Watanabe, A. Tumac, W. I. McDonald, D. A. Butterfield, P. P. Costa, F. deRino, F. Bamonti, J. M. Cesar, C. H. Lahoz, I. Mosely, M. Starck, M. H. Lemaitre, K. M. Stephan, S. Tex, R. Bokonjic, I. Mollee, L. Pastena, M. Gutierrez, F. Boiler, M. C. Martinez-Para, M. Velicogna, O. Obuz, A. Grinspan, M. Guarino, L. M. Cartier, E. Ruiz, D. Gambi, S. Messina, M. Villa, Michael G. Hanna, J. Valk, Leone Pascual, M. Clanet, Z. Argov, B. Ryniewicz, E. Magni, B. Berlanga, K. S. Wong, C. Gellera, C. Prevost, F. Gonzalez-Huix, R. Petraroli, J. E. G. Benedikz, I. Kojder, C. Bommelaer, L. Perusse, M. R. Bangioanni, Guy M. McKhann, A. Molina, C. Fresquet, E. Sindern, Florence Pasquier, M. J. Rosas, M. Altieri, O. Simoncini, M. Koutroumanidis, C. A. F. Tulleken, M. Dary-Auriol, S. Oueslati, H. Kruyer, I. Nishisho, C. R. Horning, A. Vital, G. V. Czettritz, J. Ph. Neau, B. Mihout, A. Ameri, M. Francis, S. Quasthoff, D. Taussig, S. Blunt, P. Valentin, C. Y. Gao, O. Heinzlef, H. d'Allens, C. Coudero, M. Erfas, G. Borghero, P. J. Modrego Pardo, M. C. Patrosso, N. L. Gershfeld, P. A. J. M. Boon, O. Sabouraud, M. Lara, J. Svennevig, G. L. Lenzi, A. Barrio, H. Villaroya, JosÇ M. Manubens, O. Boespflug-Tanguy, M. Carreras, D. A. Costiga, J. P. Breux, S. Lynn, C. Oliveras Ley, A. G. Herbaut, J. Nos, C. Tornali, Y. A. Hekster, J. L. Chopard, J. M. Manubens, P. Chemouilli, A. Jovicic, F. Dworzak, S. Smirne, S. E. Soudain, B. Gallano, D. Lubach, G. Masullo, G. Izquierdo, A. Pascual Leone Pascual, A. Sessa, V. Freitas, O. Crambes, L. Ouss, G. W. Van Dijk, P. Marchettini, P. Confalonieri, M. Donaghy, A. Munnich, M. Corbo, and M. E. L. van der Burg

Subjects
Neurology, business.industry, Media studies, Library science, Medicine, Neurology (clinical), business
Published
1994
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14. Concentrations of selected heavy metals in Ligula intestinalis L., 1758 plerocercoids (Cestoda) compared to it host's (Tinca tinca L., 1758) organs from Beysehir Lake (Turkey)

Author

M. Barlas, S. Teki̇n-Özan, and MÜ

Subjects
Pollution, Medicine (General), Veterinary medicine, Turkey, Agriculture (General), media_common.quotation_subject, Cestoda, Biology, S1-972, R5-920, ligula intestinalis, medicine, turkey, Parasite hosting, pollution, tench, Ligula intestinalis, heavy metals, Body cavity, media_common, Host (biology), Ecology, Intermediate host, biology.organism_classification, medicine.anatomical_structure, parasite, Animal Science and Zoology, Parasitology, Fish gill
Abstract

The accumulation of heavy metals (Cu, Fe, Zn and Mn) was measured by atomic absorption spectrophotometry in some organs of tench (Tinca tinca L., 1758) and tissues of its parasite collected from Beyşehir Lake, and compared with the data from sediments and water. The Cu levels in L. intestinalis L., 1758 plerocercoids were 1.69 times, respectively, higher than those in fish gill. Zn level in L. intestinalis plerocercoids was 2.13 times higher than those in fish liver, was 5.53 times higher than that of the muscle and 3.33 times higher than that in the gill. Significant negative (for Mn) correlation was found between the quantity of heavy metals in water and tissues of L. intestinalis plerocercoids while there was significant negative (for Cu) correlation between the quantity the heavy metals in bottom sediment and tissues of L. intestinalis plerocercoids. This study supports the idea that cestodes aren’t very useful to determine the heavy metal pollution in aquatic system when they are located in their intermediate host’s body cavity.

Published
2008

15. Reduction of surgery-induced peritoneal adhesions by continuous release of streptokinase from a drug delivery system

Author

M. Barlas, A. Yagmurlu, I.H. Gokcora, and Ihsan Gursel

Subjects
medicine.medical_specialty, medicine.medical_treatment, Streptokinase, Administration, Topical, Polyesters, Adhesion (medicine), Tissue Adhesions, Peritoneal Diseases, Severity of Illness Index, Peritoneal cavity, Drug Delivery Systems, Peritoneum, Fibrinolytic Agents, Abdomen, medicine, Animals, Rats, Wistar, Chemotherapy, business.industry, Foreign-Body Reaction, Membranes, Artificial, medicine.disease, Surgery, Rats, medicine.anatomical_structure, Drug delivery, Female, Complication, business, medicine.drug
Abstract

Postoperative abdominal adhesions may lead to intestinal obstruction and infertility. The effect of continuous release of streptokinase to the peritoneal cavity on postoperative adhesions was examined under experimental conditions. Peritoneal adhesions were induced in rats and the animals were further treated by intraperitoneal administration of streptokinase solution, polyhydroxybutyrate-co-hydroxyvalerate (PHBV) membrane alone and streptokinase loaded PHBV membrane and compared to sham operated and untreated groups. Formation of adhesions was evaluated by quantitative macroscopic grading, histopathologically with light microscopy, on the following week. Streptokinase loaded PHBV prevented postoperative adhesion formation in 90% of the cases. PHBV membrane alone also reduced the severity of adhesions due to its anti-adhesive properties. Histopathological examination revealed limited foreign body reaction due to PHBV. Continuous streptokinase activity in the peritoneal cavity during early post-surgical period prevents postoperative adhesion.

Published
2002

16. Primary gastrointestinal cancers in the Western Region of Saudi Arabia. Is the pattern changing?

Author

A O, Al-Radi, M, Ayyub, F M, Al-Mashat, S M, Barlas, N A, Al-Hamdan, D S, Ajarim, H M, Ghafouri, O M, Koriech, H Y, Alidrissi, and A A, Alsonossi

Subjects
Adult, Aged, 80 and over, Male, Adolescent, Incidence, Saudi Arabia, Infant, Middle Aged, Age Distribution, Residence Characteristics, Risk Factors, Child, Preschool, Population Surveillance, Ethnicity, Humans, Female, Registries, Sex Distribution, Child, Aged, Gastrointestinal Neoplasms
Abstract

To determine the age, sex and relative frequencies of various gastrointestinal malignancies in patients registered with the National Cancer Registry from the Western Region of Saudi Arabia from January 1994 till December 1997, and compare this data with previous hospital based studies about the pattern of these malignancies in Saudi Arabia.A National Cancer Registry was established in Saudi Arabia in 1992, and since 1st January 1994 all cancer cases in Saudi Arabia have been registered with the National Cancer Registry. All National Cancer Registry data on patients with primary gastrointestinal cancers from the Western Region of Saudi Arabia from January 1994 till December 1997 was retrieved and analyzed according to ethnic origin, site, age, sex and relative frequencies of various tumors.Out of a total of 1833 cases with primary gastrointestinal malignancies 1207 (66%) were Saudis, while the rest were Non-Saudis. Colorectal cancer was the the most common malignancy found in both population groups accounting for 28.5% of cases in Saudis and 36% in Non-Saudis. Malignancies of liver, stomach and esophagus followed in decreasing frequencies. The mean age of the Saudi population was 58+16 years (standard deviation) with male to female ratio of 1.67:1. About 80% of the patients were above 40 years of age and the peak of onset for most of the tumors was between 50 and 70 years of age.This study highlights that colorectal cancer is the most common gastrointestinal malignancy seen in the Western Region of Saudi Arabia followed by hepatocellular carcinoma. This is in sharp contrast to the previous hospital based studies from Saudi Arabia and national trends as seen in the cancer incidence report from the National Cancer Registry of Saudi Arabia. The factors for this changing pattern of gastrointestinal malignancy remain to the determined.

Published
2001

17. Histologic and ultrastructural changes in the contralateral ovary in unilateral ovarian torsion: an experimental study in rabbits

Author

M, Cakmak, M, Kaya, M, Barlas, H, Dindar, H, Gökçora, R, Konkan, and S, Yücesan

Subjects
Cell Nucleus, Microscopy, Electron, Torsion Abnormality, Ovary, Animals, Female, Ovarian Diseases, Rabbits, Lysosomes, Mitochondria
Abstract

This study was planned to investigate the extent of cellular damage of the contralateral ovary in unilateral ovarian torsion and to determine possible changes histopathologically by light and ultrastructurally by electron microscopy. Unilateral ovarian torsion was performed in 21 prepubertal, female New Zealand rabbits. One, 8 and 24 hours after the torsion, contralateral ovaries were biopsied. The control group consisted of rabbits without any torsion. Contralateral cellular damage was demonstrated after unilateral torsion. Oocytic nuclei, mitochondria, lysosomes and ovarian stromal cells were also affected when evaluated ultrastructurally.

Published
1993

18. The effect of electromagnetic field stimulation on corticosteroids-inhibited intestinal wound healing

Author

H, Dindar, N, Renda, M, Barlas, A, Akinay, E, Yazgan, T, Tinçer, M, Cakmak, R, Konkan, I H, Gökçora, and S, Yücesan

Subjects
Hydroxyproline, Wound Healing, Time Factors, Ileum, Tensile Strength, Animals, Electric Stimulation Therapy, Rats, Wistar, Dexamethasone, Rats
Abstract

Electromagnetic field (EMF) stimulation has been used successfully in the clinical setting to promote healing of ununited fractures. In a few studies, EMF stimulation enhanced soft tissue healing. To investigate the effect of EMF stimulation on intestinal wound healing in normal rats and in those treated with corticosteroids, 80 Wistar rats received twice-daily injections of either saline dexamethasone (0.1 mg/kg/day for 2 weeks. Animals then underwent creation of single-layer, inverting small intestine anastomoses. All injections were continued postoperatively. Animals were grouped as intestinal anastomoses; intestinal anastomoses plus EMF stimulation; intestinal anastomoses plus dexamethasone; and intestinal anastomoses plus dexamethasone plus EMF. On postoperative days 7 and 14, the anastomosed intestines were removed and the tensile strength (TS) and hydroxyproline (OH-P) contents measured. EMF stimulation significantly increased intestinal wound healing in normal animals by the 7th and 14th day. Corticosteroids significantly impaired the healing of the small intestine anastomoses, with decreased TS and OH-P contents after the first and second weeks. However, EMF stimulation significantly reversed this inhibitory effect.

Published
1993

19. Augmentation of mucosal adaptation following small-bowel resection by electromagnetic field stimulation in rats

Author

H, Dindar, N, Zeybek, S, Yücesan, M, Barlas, Z, Yurtaslani, E, Yazgan, R, Konkan, I F, Ozgüner, and I H, Gökçora

Subjects
Male, Short Bowel Syndrome, Hyperplasia, Proteins, Electric Stimulation Therapy, alpha-Glucosidases, Hypertrophy, Alkaline Phosphatase, beta-Galactosidase, Adaptation, Physiological, Rats, Intestine, Small, Animals, Intestinal Mucosa, Rats, Wistar, Lactase
Abstract

Survival following massive resection of the small intestine is often possible due to substantial hyperplasia of the mucosal surface in the remaining small intestine. While nutrients provide the major stimulus for hyperplasia in the clinical setting, the availability of drugs to augment this process would have obvious therapeutic implications. Electromagnetic field stimulation (EMF) of connective tissue and skin increased the DNA and messenger RNA and protein synthesis in experimental studies. We evaluated the ability of electromagnetic field stimulation to augment mucosal hyperplasia following massive small bowel resection in the rat. Two groups of 10 Wistar rats, 250 gr body weight, were subjected to 70% jejunoileal resection. The first group received EMF stimulation for ten days at a dosage of 43.20 gauss, the second group did not receive any stimulation. After fourteen days, segmental evaluation of mucosal mass in the remaining small intestine was determined by measuring mucosal protein, and disaccharidase levels, as well as intestinal length and circumference. EMF stimulation appears to augment mucosal adaptation following massive small bowel resection in rat, in the proximal and distal small intestine.

Published
1993

21. 269 Congenital myasthenic syndromes

Author

Zuhal Yapici, M. Ertas, E. Deniz, M. Barlas, F. Erdoǧan, H. :Ozcan, and Mefkure Eraksoy

Subjects
Pediatrics, medicine.medical_specialty, business.industry, Pediatrics, Perinatology and Child Health, Medicine, Neurology (clinical), General Medicine, business, Myasthenic syndromes
Published
1999
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22. 270 Infantile neuroaxonal dystrophy: Report of two cases

Author

E. Deniz, Zuhal Yapici, H. :Ozcan, F. Erdoǧan, M. Barlas, Mefkure Eraksoy, M. Ertas, and Y. Parman

Subjects
Infantile neuroaxonal dystrophy, Pathology, medicine.medical_specialty, business.industry, Pediatrics, Perinatology and Child Health, medicine, Neurology (clinical), General Medicine, medicine.disease, business
Published
1999
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24. A regulatory mutation in yeast which affects catalase T formation and metabolism of carbohydrate reserves

Author

A. Chvojka, G. R. C. B. Padrão, Anita D. Panek, James R. Mattoon, Helmut Ruis, and M. Barlas

Subjects
Glycogen, Kinase, Saccharomyces cerevisiae, General Medicine, Metabolism, Biology, biology.organism_classification, Trehalose, Phenotype, chemistry.chemical_compound, chemistry, Biochemistry, Catalase, Genetics, biology.protein, Glycogen synthase
Abstract

Mutations at the GLC1 locus in Saccharomyces cerevisiae result in a major deficiency in synthesis of catalase T, but do not affect catalase A. Three independent glc1 mutations were shown to have the same pleiotropic phenotype: catalase T deficiency, defective glycogen synthesis and defective trehalose accumulation. These three deficiencies appear to be determined by a single, nuclear gene. The possibility that glc1 mutations alter a protein kinase is considered.

Published
1981
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25. OxRAM for embedded solutions on advanced node: scaling perspectives considering statistical reliability and design constraints

Author

R. Fournel, G. Audoit, N. Castellani, M. Barlas, J. F. Nodin, Gabriel Molas, Etienne Nowak, I. Hammad, Carlo Cagli, V. Meli, Laurent Grenouillet, F. Gaillard, S. Van Duijn, J. Sandrini, F. Aussenac, O. Billoint, and S. Bernasconi

Subjects
010302 applied physics, Computer science, Transistor, High voltage, 01 natural sciences, Manufacturing cost, law.invention, law, 0103 physical sciences, Electronic engineering, Node (circuits), Data retention, Scaling, Reliability (statistics), Voltage
Abstract

OxRAM technology is one of the strongest candidates for embedded solutions at scaled nodes (

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26. Design and rationale of a clinical trial to increase cardiomyocyte division in infants with tetralogy of Fallot.

Author

El Khoudary SR, Fabio A, Yester JW, Steinhauser ML, Christopher AB, Gyngard F, Adams PS, Morell VO, Viegas M, Da Silva JP, Da Silva LF, Castro-Medina M, McCormick A, Reyes-Múgica M, Barlas M, Liu H, Thomas D, Ammanamanchi N, Sada R, Cuda M, Hartigan E, Groscost DK, and Kühn B

Subjects
Humans, Infant, Myocytes, Cardiac, Randomized Controlled Trials as Topic, Receptors, Adrenergic, beta-2, Ventricular Remodeling, Pulmonary Valve Stenosis, Tetralogy of Fallot diagnostic imaging, Tetralogy of Fallot surgery
Abstract

Background: Patients with Tetralogy of Fallot with pulmonary stenosis (ToF/PS), the most common form of cyanotic congenital heart disease (CHD), develop adverse right ventricular (RV) remodeling, leading to late heart failure and arrhythmia. We recently demonstrated that overactive β-adrenergic receptor signaling inhibits cardiomyocyte division in ToF/PS infants, providing a conceptual basis for the hypothesis that treatment with the β-adrenergic receptor blocker, propranolol, early in life would increase cardiomyocyte division. No data are available in ToF/PS infants on the efficacy of propranolol as a possible novel therapeutic option to increase cardiomyocyte division and potentially reduce adverse RV remodeling., Methods: Using a randomized, double-blind, placebo-controlled trial, we will evaluate the effect of propranolol administration on reactivating cardiomyocyte proliferation to prevent adverse RV remodeling in 40 infants with ToF/PS. Propranolol administration (1 mg/kg po QID) will begin at 1 month of age and last until surgical repair. The primary endpoint is cardiomyocyte division, quantified after 15 N-thymidine administration with Multi-isotope Imaging Mass Spectrometry (MIMS) analysis of resected myocardial specimens. The secondary endpoints are changes in RV myocardial and cardiomyocyte hypertrophy., Conclusion: This trial will be the first study in humans to assess whether cardiomyocyte proliferation can be pharmacologically increased. If successful, the results could introduce a paradigm shift in the management of patients with ToF/PS from a purely surgical approach, to synergistic medical and surgical management. It will provide the basis for future multi-center randomized controlled trials of propranolol administration in infants with ToF/PS and other types of CHD with RV hypertension., Clinical Trial Registration: The trial protocol was registered at clinicaltrials.gov (NCT04713657)., (Copyright © 2021 Elsevier B.V. All rights reserved.)

Published
2021
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27. Prehospital oxygen for stroke victims.

Author

Collins J, Sumner M, Barlas M, Strickland PO, and McCoy J

Subjects
Humans, Oxygen, Retrospective Studies, Emergency Medical Services, Stroke therapy
Abstract

Competing Interests: Declaration of competing interest Dr. McCoy was site PI for RE VERSE AD study, a multi-center study on dabigatran reversal with support from Boerhinger-Ingelheim. The study is now closed and the aims were unrelated to our current study. Sincerely, John Collins, MD Associate Professor Department of Emergency Medicine Rutgers - Robert Wood Johnson Medical School One Robert Wood Johnson Place MEB 104 New Brunswick, NJ 08901 Tel: 732-235-8717 Fax: 732-235-7379 collinjj@rwjms.rutgers.edu

Published
2021
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28. Electrical Characterization of the Backside Interface on BSI Global Shutter Pixels with Tungsten-Shield Test Structures on CDTI Process.

Author

Doyen C, Ricq S, Magnan P, Marcelot O, Barlas M, and Place S

Abstract

A new methodology is presented using well known electrical characterization techniques on dedicated single devices in order to investigate backside interface contribution to the measured pixel dark current in BSI CMOS image sensors technologies. Extractions of interface states and charges within the dielectric densities are achieved. The results show that, in our case, the density of state is not directly the source of dark current excursions. The quality of the passivation of the backside interface appears to be the key factor. Thanks to the presented new test structures, it has been demonstrated that the backside interface contribution to dark current can be investigated separately from other sources of dark current, such as the frontside interface, DTI (deep trench isolation), etc.

Published
2020
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29. Cell Type-Specific p38δ Targeting Reveals a Context-, Stage-, and Sex-Dependent Regulation of Skin Carcinogenesis.

Author

Kiss A, Koppel AC, Murphy E, Sall M, Barlas M, Kissling G, and Efimova T

Subjects
9,10-Dimethyl-1,2-benzanthracene, Animals, Carcinogenesis pathology, Carcinoma, Squamous Cell enzymology, Carcinoma, Squamous Cell pathology, Cell Proliferation, Cytokines metabolism, Disease Progression, Female, Gene Deletion, Inflammation Mediators metabolism, Keratinocytes enzymology, Male, Mice, Knockout, Myeloid Cells metabolism, Neoplasm Staging, Phenotype, Skin pathology, Tetradecanoylphorbol Acetate, Mitogen-Activated Protein Kinase 13 metabolism, Sex Characteristics, Skin Neoplasms enzymology, Skin Neoplasms pathology
Abstract

Activation and/or upregulated expression of p38δ are demonstrated in human skin malignancies including cutaneous squamous cell carcinoma, suggesting a role for p38δ in skin carcinogenesis. We previously reported that mice with germline deletion of the p38δ gene are significantly protected from chemical skin carcinogenesis. Here, we investigated the effects of cell-selective targeted ablation of p38δ in keratinocytes and in immune (myeloid) cells on skin tumor development in a two-stage 7,12-dimethylbenz( a )anthracene (DMBA)/12- O -tetradecanoylphorbol-13-acetate (TPA) chemical mouse skin carcinogenesis model. Conditional keratinocyte-specific p38δ ablation (p38δ-cKO ∆K ) did not influence the latency, incidence, or multiplicity of chemically-induced skin tumors, but led to increased tumor volume in females during the TPA promotion stage, and reduced malignant progression in males and females relative to their wild-type counterparts. In contrast, conditional myeloid cell-specific p38δ deletion (p38δ-cKO ∆M ) inhibited DMBA/TPA-induced skin tumorigenesis in male but not female mice. Thus, tumor onset was delayed, and tumor incidence, multiplicity, and volume were reduced in p38δ-cKO ∆M males compared with control wild-type males. Moreover, the percentage of male mice with malignant tumors was decreased in the p38δ-cKO ∆M group relative to their wild-type counterparts. Collectively, these results reveal that cell-specific p38δ targeting modifies susceptibility to chemical skin carcinogenesis in a context-, stage-, and sex-specific manner.

Published
2019
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30. [An investigation of parasites of tench (Tinca tinca L., 1758) in Beyşehir Lake].

Author

Ozan ST, Kir I, Ayvaz Y, and Barlas M

Subjects
Acanthocephala classification, Animals, Cestode Infections epidemiology, Cestode Infections parasitology, Cestode Infections veterinary, Fish Diseases epidemiology, Fresh Water, Helminthiasis, Animal epidemiology, Seasons, Trematode Infections epidemiology, Trematode Infections parasitology, Trematode Infections veterinary, Turkey epidemiology, Cyprinidae parasitology, Fish Diseases parasitology, Helminthiasis, Animal parasitology
Abstract

The aim of this study that was carried out from March 15, 2003 to February15, 2005 was to determine the parasites of tench (Tinca tinca L., 1758) inhabiting the Beyşehir Lake. During the study, a total of 334 tenches (T. tinca ) were caught in different regions of Beyşehir Lake monthly and investigated parasitologically. Endoparasites in tenches were found to be plerocercoids of Ligula intestinalis, Caryophyllaeus laticeps, Bothriocephalus acheilognathi and Proteocephalus torulosus from Cestoda, Asymphylodora tincae from Digenea and Acanthocephalus anguillae from Acanthocephala. Of these parasites, Acanthocephalus anguillae has been recorded for the first time in the tenchs of Turkey.

Published
2006

31. Catheter-related fungemia caused by Saccharomyces cerevisiae in a newborn.

Author

Belet N, Dalgiç N, Oncel S, Ciftçi E, Ince E, Güriz H, Barlas M, and Doğru U

Subjects
Amphotericin B therapeutic use, Antifungal Agents therapeutic use, Female, Humans, Infant, Newborn, Mycoses drug therapy, Mycoses microbiology, Catheterization, Central Venous adverse effects, Fungemia microbiology, Saccharomyces cerevisiae isolation & purification
Published
2005
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32. Does L-arginine induce intestinal adaptation by epithelial growth factor?

Author

Camli A, Barlas M, and Yagmurlu A

Subjects
Adaptation, Physiological, Animals, Male, Rats, Rats, Wistar, Arginine pharmacology, Epidermal Growth Factor drug effects, Epidermal Growth Factor metabolism, Intestine, Small physiology, Intestine, Small surgery
Abstract

Background: To evaluate whether L-Arginine has an effect on endogenous epidermal growth factor secretion and intestinal adaptation in massive small bowel resection an experimental study was performed., Methods: Fourteen albino Wistar rats weighing 250-300 g were used for the study. After performing 50% small bowel resection and anastomosis the rats were randomly divided into two groups. The first group received 500 mg/kg/day of L-Arginine intraperitoneally for 14 days just after the surgical procedure. The control group received isotonic saline instead. Body weight measurement was preformed daily. At the end of the second postoperative week all rats underwent relaparotomy. Small bowel was resected for histopathological examination. Levels of epidermal growth factor were measured by enzyme-linked immunosorbent assay in serum, saliva, and urine at the end of second postoperative week in both groups., Results: The weight gain was higher in the L-Arginine treated group (P < 0.05). Serum, saliva and urinary epidermal growth factor levels were significantly higher at the end of the second week compared to the control group (P < 0.05). The villus height was higher on histopathological examination in L-Arginine treated group compared to the control group (P < 0.05)., Conclusion: L-Arginine resulted in a better intestinal adaptation after massive bowel resection. The high levels of epidermal growth factor in body fluids of L-Arginine treated rats could be the explanation for this effect.

Published
2005
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33. The effect on the intestines of continuous release of methylene blue from a drug delivery system: an experimental study in a chick embryo gastroschisis model.

Author

Denli O, Barlas M, Bingol-Kologlu M, Yagmurlu A, Ozdamar S, Hasçiçek C, and Cedden F

Subjects
Administration, Topical, Amniotic Fluid drug effects, Animals, Chick Embryo, Disease Models, Animal, Drug Delivery Systems methods, Ganglia, Autonomic pathology, Gastrointestinal Motility physiology, Intestinal Diseases etiology, Intestinal Diseases physiopathology, Intestines pathology, Nitric Oxide Synthase antagonists & inhibitors, Nitric Oxide Synthase physiology, Enzyme Inhibitors administration & dosage, Gastrointestinal Motility drug effects, Gastroschisis complications, Intestinal Diseases drug therapy, Intestines drug effects, Methylene Blue administration & dosage
Abstract

Increased small bowel nitric oxide synthase (NOS) activity has been suspected as a cause of postnatal intestinal dysmotility in gastroschisis. The effect of continuous delivery of methylene blue loaded polymer (MBLP) hydroxy-propyl methyl cellulose-ethyl cellulose (HPEC-MC) and daily injection of methylene blue (MB) on the intestinal damage (ID) was evaluated using a chick embryo gastroschisis model. Fourteen-day-old fertilized chick eggs were divided into five groups. In the control (C) group, no intervention was performed. In the sham (S) group, the allantoic and amniotic membranes were opened to create a common cavity that resembles the amniotic cavity in human. In the gastroschisis only (GO) group, a defect in the abdominal wall of the embryo was made, and intestinal loops were exteriorized following connection of amniotic and allantoic cavities. In the gastroschisis plus methylene blue (G+MB) group, gastroschisis was created and MB administered into the amnioallantoic cavity (AAC) by daily injections for 5 days. In the gastroschisis plus methylene blue loaded polymer (G+MBLP) group, MBLP was placed into AAC after gastroschisis was created. At the end of the 19th day of incubation, intestinal morphological changes were investigated macroscopically and microscopically. Although the survival rates were decreased in the chick embryos with creation of gastroschisis compared with C and S groups ( p<0.001), the survival rates were increased in G+MBLP group (76.92%) when compared with the GO group (41%) ( p<0.001). Because of multiple intervention of embryos, higher mortality was observed in the G-MB group (75.61%). Macroscopic and microscopic scores of ID and mean intestinal wall thickness were significantly higher in the GO group when compared with C, S, G+MB, and G+MBLP groups ( p<0.001). The mean score of intestinal ganglia morphology was significantly increased and the total number of ganglion cells was significantly decreased in the GO group when compared with C, S, G+MB, and G+MBLP groups ( p<0.001). It is possible to decrease intrauterine intestinal morphological changes in gastroschisis by inhibiting NOS. As a first preliminary study, we believe that use of MBLP may be an alternative for fetal treatment by eliminating the harmful effects of multiple interventions or amniotic fluid exchanges.

Published
2004
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34. Reduction of surgery-induced peritoneal adhesions by continuous release of streptokinase from a drug delivery system.

Author

Yagmurlu A, Barlas M, Gursel I, and Gokcora IH

Subjects
Administration, Topical, Animals, Female, Foreign-Body Reaction etiology, Membranes, Artificial, Peritoneal Diseases pathology, Polyesters adverse effects, Rats, Rats, Wistar, Severity of Illness Index, Tissue Adhesions pathology, Abdomen surgery, Drug Delivery Systems, Fibrinolytic Agents administration & dosage, Peritoneal Diseases prevention & control, Streptokinase administration & dosage, Tissue Adhesions prevention & control
Abstract

Postoperative abdominal adhesions may lead to intestinal obstruction and infertility. The effect of continuous release of streptokinase to the peritoneal cavity on postoperative adhesions was examined under experimental conditions. Peritoneal adhesions were induced in rats and the animals were further treated by intraperitoneal administration of streptokinase solution, polyhydroxybutyrate-co-hydroxyvalerate (PHBV) membrane alone and streptokinase loaded PHBV membrane and compared to sham operated and untreated groups. Formation of adhesions was evaluated by quantitative macroscopic grading, histopathologically with light microscopy, on the following week. Streptokinase loaded PHBV prevented postoperative adhesion formation in 90% of the cases. PHBV membrane alone also reduced the severity of adhesions due to its anti-adhesive properties. Histopathological examination revealed limited foreign body reaction due to PHBV. Continuous streptokinase activity in the peritoneal cavity during early post-surgical period prevents postoperative adhesion., (Copyright 2003 S. Karger AG, Basel)

Published
2003
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35. The effect of nitric oxide in testicular ischemia-reperfusion injury.

Author

Barlas M and Hatiboğlu C

Subjects
Animals, Male, Rats, Rats, Wistar, Nitric Oxide physiology, Reperfusion Injury physiopathology, Spermatic Cord Torsion physiopathology, Testis blood supply
Abstract

Unlabelled: This experiment was carried out to investigate the effect of endogenous nitric oxide (NO) on the ischemia-reperfusion injury of testis. Testicular ischemia was achieved by twisting the right testis and spermatic cord 1080 counter-clockwise for 30 minutes and reperfusion was allowed for 30 minutes after detorsion of 33 rats. Animals were treated with normal saline in controls just before detorsion, NG-nitro-L-arginine methyl ester (L-NAME), and L-arginine (L-arg) in others. The tissue damage was evaluated with light microscopy, malondialdehyde (MDA) level in tissue, and the blood flow measurement using 133xenon (Xe) clearence technique. MDA indicator of reperfusion injury increased 25% after detorsion when only normal saline was given, L-NAME further increased MDA, L-arginin decreased MDA to control level., Conclusion: L-arginin infusion during the detorsion reduced the reperfusion injury of testis and improved the testicular blood flow after the detorsion.

Published
2002
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36. The effects of piroxicam to the muscosal barrier of the bladder after overdistension--an experimental study in rabbits.

Author

Barlas M

Subjects
Animals, Disease Models, Animal, Inflammation, Male, Mucous Membrane drug effects, Rabbits, Urinary Bladder pathology, Urinary Bladder Neck Obstruction, Anti-Inflammatory Agents, Non-Steroidal pharmacology, Piroxicam pharmacology, Urinary Bladder drug effects
Abstract

Unlabelled: The effects of piroxicam on the duration and severity of damage to the mucosal barrier of the urinary bladder after overdistension was investigated. Overdistension of the bladder was induced for 3 h in 16 New Zealand male rabbits by giving Ringer's lactate infusion (40 mL/kg/h) and furosemide (1 mg/kg) to the peritoneal cavity. Insertion of 8 Fr Foley catheter was used for obstruction of the bladder neck. In both control (C) and piroxicam (P) groups, 20 mL of 2% solution of Trypan blue in 0.9% NaCl solution was instilled into the bladder for 1 hr at 0, 24, 48 h and 7 days after overdistension. In group P daily intramuscular injection of 5 mg/kg piroxicam, and isotonic saline in group C was administrated for 7 days. Full-thickness samples were taken from the bladder at 0, 24, 48 h and 7 days after overdistension. The bladder wall was deep blue throughout in both groups at 0, 24, and 48 h. The severity and duration of inflammatory reaction was lower and nearly normalized on the 7th post procedure day in piroxicam group., Conclusion: Inflammatory reaction can be prevented by administration of anti-inflammatory drugs such as piroxicam but the prevention of increased permeability is unclear after overdistension of the bladder.

Published
2002
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37. Antimicrobial Effects of Propolis Extracts on Escherichia coli and Staphylococcus aureus Strains Resistant to Various Antibiotics and Some Microorganisms.

Author

Ugur A, Barlas M, Ceyhan N, and Turkmen V

Abstract

ABSTRACT Propolis is collected by worker honey bees from the trees. The bees pack propolis on their hind legs, carry it to their colony, and use it as a sterilant in the hive. Propolis has also been used by humans since early times for various purposes and, especially, as a medicine because of its antimicrobial properties. In this study, antimicrobial effects of propolis samples on three Escherichia coli and two Staphylococcus aureus strains that are multiresistant to antibiotics and on Salmonella typhimurium, Bruceila abortus, Proteus mirabilis, Streptococcus pyogenes, Bacillus cereus, Candida tropicalis, and Aspergillus niger were studied. Propolis extracts were prepared with acetone and dimethyl sulfoxide (DMSO). At concentrations of 10 and 25 ml, propolis extracts affected all of the microorganisms in acetone and DMSO in concentrations of 10.0, 50.0, and 100.0 ppm. The results detected in this in vitro study provided evidence that propolis may be used as an antimicrobial agent against many microorganisms.

Published
2000
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38. Correlation between clinical stages and EEG findings of subacute sclerosing panencephalitis.

Author

Gürses C, Oztürk A, Baykan B, Gökyiğit A, Eraksoy M, Barlas M, Calişkan A, and Ozcan H

Subjects
Adolescent, Female, Humans, Male, Retrospective Studies, Subacute Sclerosing Panencephalitis classification, Subacute Sclerosing Panencephalitis physiopathology, Brain physiopathology, Electroencephalography, Subacute Sclerosing Panencephalitis diagnosis
Abstract

In this retrospective study 67 patients with SSPE seen between the years 1980 and 1998 were reviewed. Using the criteria of SSPE diagnosis (clinical signs, characteristic EEG patterns, high titres of measles antibodies in the serum and CSF), the patients were divided into two groups. Group A fulfilled all criteria, however, due to the inability of measuring measles antibody before 1987, it was not possible to observe the third criterion in Group B. Among 67 patients, groups A and B consisted of 51 boys and 16 girls ranging in age between 1 to 23 years, mean age 13.1. The male/female ratio was 3.1. The periodic EEG complexes (PCs) were usually bilateral, synchronous and symmetrical. PC amplitude asymmetry was seen in 12 patients and 2 patients had no PC synchronization between the hemispheres. Six patients had more than one form of PC. Delta activity in anterior hemispheres after PC was seen in 40 patients, mostly in stage 2A. Thirty-two patients had focal epileptiform abnormalities in multiple locations at every stage but most frequently in frontal, central and temporal regions. One patient had PC over both hemispheres and periodic lateralized epileptiform discharges (PLEDs) over the right hemisphere. The EEG findings described and observed in our study do not seem to be specific to SSPE but these findings were not atypical or unusual.

Published
2000
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39. Neonatal hypertrophic pyloric stenosis: congenital or infantile?

Author

Hatiboğlu MC, Dindar H, Cakmak M, Kanmaz T, Naycl A, Barlas M, Gökçora H, and Yücesan S

Subjects
Adult, Female, Gastric Emptying, Hematemesis etiology, Hematemesis physiopathology, Humans, Hypertrophy, Infant, Newborn, Laparotomy, Male, Pregnancy, Pyloric Stenosis diagnosis, Pyloric Stenosis surgery, Pylorus surgery, Pyloric Stenosis congenital
Abstract

Hypertrophic pyloric stenosis (HPS) is very rare during the newborn period. Here we present a fullterm male neonate with abundant hematemesis 12 hours after birth which interrupted oral feeding. Bleeding subsided within three days after conservative measures, and oral feeding was restarted but not tolerated. The vomiting was effortless and nonbilious. An upper gastrointestinal series revealed gastric dilatation and partial obstruction of the gastric outlet. HPS was found by laparotomy on the fourth day and Fredet-Ramstedt pyloromyotomy relieved the gastric emptying. This is one of the few cases of HPS present at birth, which was diagnosed and surgically treated early, and we suggest a congenital etiology in previously reported cases of HPS. Hypertrophic pyloric stenosis (HPS) is a common cause of pediatric surgery. Usually young infants are involved; HPS is extremely rare in neonates and infants older than 6 months. Vomiting typically begins between the 3rd and 6th week of life, although some infants may have mild symptoms like regurgitation from birth.

Published
1996

40. MRI in subacute sclerosing panencephalitis.

Author

Tuncay R, Akman-Demir G, Gökyigit A, Eraksoy M, Barlas M, Tolun R, and Gürsoy G

Subjects
Adolescent, Adult, Brain pathology, Cerebral Cortex pathology, Cerebral Ventricles pathology, Child, Diagnosis, Differential, Dominance, Cerebral physiology, Female, Follow-Up Studies, Humans, Male, Magnetic Resonance Imaging, Subacute Sclerosing Panencephalitis diagnosis
Abstract

Subacute sclerosing panencephalitis (SSPE) is a progressive, slow virus infection of the brain, caused by the measles virus, attacking children and young adults. We investigated 15 patients with SSPE by MRI, with 5 normal and 10 pathological results. In the early period, lesions were in the grey matter and subcortical white matter. They were asymmetrical and had a predilection for the posterior parts of the hemispheres. Later, high-signal changes in deep white matter and severe cerebral atrophy were observed. Parenchymal lesions significantly correlated with the duration of disease. A significant relationship between MRI findings and clinical stage was observed in the 1st year of the disease.

Published
1996
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41. Distal penile hypospadias repair in children, with complete mobilization of pendulous urethra and triangular glandular flap.

Author

Dindar H, Cakmak M, Yücesan S, and Barlas M

Subjects
Anastomosis, Surgical, Child, Humans, Male, Urethra surgery, Hypospadias surgery, Penis surgery, Surgical Flaps methods
Abstract

Objective: To present a technique for repair of distal hypospadias., Patients and Methods: Sixteen children (average age 6.6 years) were treated between January 1985 and January 1991. The procedure is described., Results: One child developed a mild meatal stenosis and another had a small urethral fistula; both responded to treatment. Results were excellent in the remaining 14 patients., Conclusion: This simple operative procedure was successful in the majority of patients and there were only two minor complications.

Published
1995
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42. Blood flow determination in contralateral ovary with 133 Xe in unilateral ovarian torsion (experimental study in rabbits).

Author

Cakmak M, Aras T, Ercan M, Dindar H, Barlas M, Konkan R, Gökçora H, and Yücesan S

Subjects
Animals, Female, Laparotomy, Rabbits, Torsion Abnormality, Xenon Radioisotopes, Ovarian Diseases, Ovary blood supply
Abstract

Clinical and experimental studies have shown that, in unilateral testicular torsion, some structural and hormonal changes may occur in the contralateral testis. The present study was designed to determine the effect of unilateral ovarian torsion on the blood flow in the contralateral ovary using #133Xe. Basal blood flow of the bilateral ovaries was determined in 40 prepubertal, female New Zealand rabbits. Right ovaries were then torsioned 720 degrees in all groups with the exception of the control group, where only laparotomy was performed. Bilateral ovarian blood flows were measured in the first group one hour after torsion, in the second group 8 hours after torsion, in the third group 24 hours after torsion and at the same times after laparotomy in the control group. Basal and post torsional blood flow measurements were analyzed. Contralateral ovarian blood flow was reduced after unilateral torsion in all of the groups. In the control group, there were no changes in these criteria.

Published
1994

43. A bronchopleurocutaneous fistula caused by an unusual foreign body aspiration simulating acute abdomen.

Author

Dindar H, Konkan R, Cakmak M, Barlas M, Gökcora H, and Yücesan S

Subjects
Bronchi, Bronchial Fistula diagnosis, Child, Cutaneous Fistula diagnosis, Diagnosis, Differential, Fistula diagnosis, Humans, Inhalation, Male, Pleural Diseases diagnosis, Poaceae, Abdomen, Acute etiology, Bronchial Fistula etiology, Cutaneous Fistula etiology, Fistula etiology, Foreign Bodies complications, Pleural Diseases etiology
Abstract

A 12-year-old boy was admitted to hospital for abdominal pain, vomiting and fever. On physical examination he had râles on the lower right hemithorax without any respiratory complaints. Chest X-ray revealed a condensation in the right lower chest. Abdominal findings were secondary to lobar pneumonia. Treatment of pneumonia with antibiotics showed no improvement over 2 days. On bronchoscopy no foreign body was seen, but pus was aspirated. Two days later a mass appeared on the right hemithorax and fistulized. An organic foreign body, Hordeum murinum, with 3-5 ml of pus was observed. Chest X-ray taken at the day of fistulization showed no pneumothorax or subcutaneous emphysema. Less than 11 cases of pneumocutaneous fistulas secondary to aspiration of grasses have been reported in literature. Why an ear of Hordeum murinum can migrate only in a forward direction and why a pneumothorax had not developed is discussed.

Published
1994
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44. Histologic and ultrastructural changes in the contralateral ovary in unilateral ovarian torsion: an experimental study in rabbits.

Author

Cakmak M, Kaya M, Barlas M, Dindar H, Gökçora H, Konkan R, and Yücesan S

Subjects
Animals, Cell Nucleus pathology, Cell Nucleus ultrastructure, Female, Lysosomes pathology, Lysosomes ultrastructure, Microscopy, Electron, Mitochondria pathology, Mitochondria ultrastructure, Rabbits, Torsion Abnormality, Ovarian Diseases pathology, Ovary pathology, Ovary ultrastructure
Abstract

This study was planned to investigate the extent of cellular damage of the contralateral ovary in unilateral ovarian torsion and to determine possible changes histopathologically by light and ultrastructurally by electron microscopy. Unilateral ovarian torsion was performed in 21 prepubertal, female New Zealand rabbits. One, 8 and 24 hours after the torsion, contralateral ovaries were biopsied. The control group consisted of rabbits without any torsion. Contralateral cellular damage was demonstrated after unilateral torsion. Oocytic nuclei, mitochondria, lysosomes and ovarian stromal cells were also affected when evaluated ultrastructurally.

Published
1993

45. Augmentation of mucosal adaptation following small-bowel resection by electromagnetic field stimulation in rats.

Author

Dindar H, Zeybek N, Yücesan S, Barlas M, Yurtaslani Z, Yazgan E, Konkan R, Ozgüner IF, and Gökçora IH

Subjects
Alkaline Phosphatase metabolism, Animals, Hyperplasia, Hypertrophy, Intestinal Mucosa metabolism, Intestinal Mucosa pathology, Intestine, Small metabolism, Intestine, Small pathology, Lactase, Male, Proteins metabolism, Rats, Rats, Wistar, Short Bowel Syndrome metabolism, Short Bowel Syndrome pathology, Short Bowel Syndrome surgery, alpha-Glucosidases metabolism, beta-Galactosidase metabolism, Adaptation, Physiological, Electric Stimulation Therapy, Intestine, Small surgery
Abstract

Survival following massive resection of the small intestine is often possible due to substantial hyperplasia of the mucosal surface in the remaining small intestine. While nutrients provide the major stimulus for hyperplasia in the clinical setting, the availability of drugs to augment this process would have obvious therapeutic implications. Electromagnetic field stimulation (EMF) of connective tissue and skin increased the DNA and messenger RNA and protein synthesis in experimental studies. We evaluated the ability of electromagnetic field stimulation to augment mucosal hyperplasia following massive small bowel resection in the rat. Two groups of 10 Wistar rats, 250 gr body weight, were subjected to 70% jejunoileal resection. The first group received EMF stimulation for ten days at a dosage of 43.20 gauss, the second group did not receive any stimulation. After fourteen days, segmental evaluation of mucosal mass in the remaining small intestine was determined by measuring mucosal protein, and disaccharidase levels, as well as intestinal length and circumference. EMF stimulation appears to augment mucosal adaptation following massive small bowel resection in rat, in the proximal and distal small intestine.

Published
1993

46. The effect of electromagnetic field stimulation on corticosteroids-inhibited intestinal wound healing.

Author

Dindar H, Renda N, Barlas M, Akinay A, Yazgan E, Tinçer T, Cakmak M, Konkan R, Gökçora IH, and Yücesan S

Subjects
Animals, Dexamethasone pharmacology, Hydroxyproline metabolism, Ileum physiology, Ileum surgery, Rats, Rats, Wistar, Tensile Strength, Time Factors, Electric Stimulation Therapy, Ileum injuries, Wound Healing drug effects
Abstract

Electromagnetic field (EMF) stimulation has been used successfully in the clinical setting to promote healing of ununited fractures. In a few studies, EMF stimulation enhanced soft tissue healing. To investigate the effect of EMF stimulation on intestinal wound healing in normal rats and in those treated with corticosteroids, 80 Wistar rats received twice-daily injections of either saline dexamethasone (0.1 mg/kg/day for 2 weeks. Animals then underwent creation of single-layer, inverting small intestine anastomoses. All injections were continued postoperatively. Animals were grouped as intestinal anastomoses; intestinal anastomoses plus EMF stimulation; intestinal anastomoses plus dexamethasone; and intestinal anastomoses plus dexamethasone plus EMF. On postoperative days 7 and 14, the anastomosed intestines were removed and the tensile strength (TS) and hydroxyproline (OH-P) contents measured. EMF stimulation significantly increased intestinal wound healing in normal animals by the 7th and 14th day. Corticosteroids significantly impaired the healing of the small intestine anastomoses, with decreased TS and OH-P contents after the first and second weeks. However, EMF stimulation significantly reversed this inhibitory effect.

Published
1993

47. Influence of unilateral ovarian torsion to the contralateral ovary.

Author

Cakmak M, Mergen K, Dindar H, Barlas M, Konkan R, Gökçora H, and Yücesan S

Subjects
Animals, Chorionic Gonadotropin pharmacology, Estradiol metabolism, Female, Ovarian Diseases pathology, Ovary drug effects, Ovary metabolism, Ovary pathology, Rabbits, Torsion Abnormality, Ovarian Diseases metabolism
Abstract

An experimental study was planned to show the suppression of contralateral ovary in unilateral ovarian torsions. In the study, 55 New Zealand female rabbits were used. Basal and stimulation 17 beta estradiol values were measured and unilateral torsion in 20 rabbits, bilateral torsion in ten rabbits and bilateral oophorectomy in five rabbits were performed. Eight, 16, 24 hours after the procedure, 17 beta estradiol levels were measured again and the second stimulation values maintained. The control group consisted of 20 rabbits. Values were analyzed statistically and the results were significant.

Published
1992

48. Human amniotic membrane as an intestinal patch for neomucosal growth in the rabbit model.

Author

Barlas M, Gökçora H, Erekul S, Dindar H, and Yücesan S

Subjects
Amnion cytology, Animals, Female, Humans, Ileum cytology, Intestinal Mucosa cytology, Pregnancy, Rabbits, Time Factors, Wound Healing physiology, Amnion transplantation, Ileum growth & development, Ileum surgery, Intestinal Mucosa surgery, Models, Biological, Surgical Flaps
Abstract

This experiment was carried out as a preliminary study, an attempt to grow new intestinal mucosa on human amniotic membrane in the terminal ileum in 37 rabbits. After ketamin sulfate anesthesia at laparatomy, 5-cm ileal defects were patched with human amniotic membrane (5 x 2 cm). These patched intestines were investigated on the first postoperative day and the 2nd, 5th, 10th, and 20th weeks corresponding to 4, 5, 5, 10, and 10 rabbits, respectively. Only three rabbits died in the early postoperative period. There was no evidence of intestinal obstruction or dilatation with barium meal. Microscopically, the neomucosa consisted of a thin layer of columnar epithelial cells at 2 weeks with more maturity of the villi and less irregularity and branching by 20 weeks. All patches were covered with neomucosa commencing at 2 weeks and covering the whole patch area by 20 weeks. This technique's advantages are the large size and the ease of the availability of the human amniotic membrane for neonates at risk without jeopardizing the neonates tissues. It is hoped that this method might be considered when neonatal material is scarce.

Published
1992
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49. Treatment of biliary fistulas and cholelithiasis: is endoscopic sphincterotomy acceptable in the paediatric age group?

Author

Gökçora IH, Ormeci N, Dökmecí A, and Barlas M

Subjects
Adolescent, Biliary Fistula etiology, Child, Common Bile Duct Diseases etiology, Cysts etiology, Duodenoscopy, Female, Gallstones complications, Humans, Prognosis, Biliary Fistula surgery, Cholelithiasis surgery, Postoperative Complications surgery, Sphincterotomy, Transduodenal
Abstract

Two children, both girls, aged 11 and 16 with a postoperative biliary fistula and cholelithiasis, choledochal cyst and common bile duct stones have undergone endoscopic sphincterotomy (EST), leading to a rapid recovery from their pathologies, thanks to cooperative work. In reviewing the literature we have not come across any cases of EST in our patients' age group. There were no complications during or immediately after endoscopic sphincterotomies. We believe that it has become an important and valuable rival to conventional surgical means with correct indications and in experienced hands.

Published
1989

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