181 results on '"M. Bamford"'
Search Results
2. CHIMERA Fusion Technology Facility: Testing and Virtual Qualification
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Thomas R. Barrett, M. Bamford, N. Bowden, B. Chuilon, T. Deighan, P. Efthymiou, M. Gorley, T. Grant, D. Horsley, M. Kovari, and M. Tindall
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Nuclear and High Energy Physics ,Nuclear Energy and Engineering ,Mechanical Engineering ,General Materials Science ,Civil and Structural Engineering - Published
- 2023
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3. The accuracy of extended-spectrum beta-lactamase detection in Escherichia coli and Klebsiella pneumoniae in South African laboratories using the Vitek 2 Gram-negative susceptibility card AST-N255
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Andrea L. Young, Mark P. Nicol, Clinton Moodley, and Colleen M. Bamford
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antimicrobial susceptibility testing ,extended-spectrum beta-lactamase (esbl) detection ,automated systems for esbl detection ,vitek 2 esbl detection ,gram-negative susceptibility card ast-n255 ,Infectious and parasitic diseases ,RC109-216 - Abstract
Background: Phenotypic detection of extended-spectrum beta-lactamases (ESBLs) is based on the inhibition of ESBL enzymes by β-lactamase inhibitors and on the comparison of cephalosporin activity with or without a β-lactamase inhibitor. Many South African diagnostic laboratories rely on the Vitek 2 for automated susceptibility testing and for ESBL detection. However, the Gram-negative susceptibility card currently used locally (AST-N255) has been modified and its accuracy for ESBL detection is not known. Methods: We randomly selected 50 isolates of Klebsiella pneumoniae and Escherichia coli from a collection of clinical bloodstream isolates from Groote Schuur Hospital from 2015 to 2016, including ESBL-producing and non-ESBL-producing strains. We used standardised phenotypic (disc diffusion and broth microdilution) and genotypic (conventional polymerase chain reaction (PCR) for blaCTX-M, blaSHV and blaTEM) methods for detection of ESBLs. We compared ESBL detection by Vitek 2 to a composite reference standard comprising ESBL detection either by both phenotypic methods or by one phenotypic method together with genotypic detection. Results: The sensitivity of Vitek 2 system for detection of ESBLs was 33/36 or 92% (78% – 97%) for E. coli, and 40/40 or 100% (91% – 100%) for K. pneumoniae, whilst specificity was 10/10 or 100% (72% – 100%) and 9/10 or 90% (60% – 98%), respectively. This is comparable with previous studies. Conclusion: Using a composite reference standard of the phenotypic and genotypic methods employed in this study, no Vitek-categorised ESBL E. coli or K. pneumoniae was found to be a non-ESBL with the exception of possible misinterpretation with K. pneumoniae SHV-hyper-producing isolates.
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- 2019
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4. The CHIMERA facility development programme
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T.R. Barrett, M. Bamford, B. Chuilon, T. Deighan, P. Efthymiou, L. Fletcher, M. Gorley, T. Grant, T. Hall, D. Horsley, M. Kovari, and M. Tindall
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Nuclear Energy and Engineering ,Mechanical Engineering ,General Materials Science ,Civil and Structural Engineering - Published
- 2023
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5. Developing a voice monitoring smartphone app: Acoustic acquisition and processing considerations
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Victoria S. McKenna, Andres F. Llico, Aaron Friedman, Savannah N. Shanley, Thomas Talavage, and Leigh M. Bamford
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Acoustics and Ultrasonics ,Arts and Humanities (miscellaneous) - Abstract
With the advent of smartphone technology, there has been an increase in at-home health monitoring. Yet, there are few applications (apps) available to track voice acoustics for those with voice disorders. Therefore, we completed two investigations into the acquisition and processing of the acoustic signal to help develop a voice monitoring app. Study 1: We investigated how microphone distance and phone tilt impact the accuracy of acoustic measures of voice. A total of 58 participants with (n = 47) and without (n = 11) voice disorders completed speech tasks of sustained vowels and the rainbow passage. Concurrent recordings were collected using the participant’s phone, as well as a stationary headset microphone for comparison. We determined that the voice measures of fundamental frequency (Hz), voicing duration (seconds), and cepstral peak prominence (dB) were impervious to phone distance and tilt. Study 2: Focusing on the three acoustic measures from study 1, we investigated the correspondence between acoustic measures attained with clinically available software (e.g., Praat) and those from our own lab-developed algorithms specialized for on-app processing. Preliminary results show strong relationships ( r > .90) between the different processing techniques. Further work is needed to understand how participant-specific factors (age, dysphonia severity) may improve algorithm accuracy.
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- 2022
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6. Oxfordshire Community Stroke Project Classification: A proposed automated algorithm
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John M. Bamford, João Brainer Clares de Andrade, Joao Vitor da Silva Moreira, Camila Rodrigues Nepomuceno, Fabricio O Lima, Isabelle da Costa Goes Timbó, Jay P. Mohr, Gisele Sampaio Silva, and Felipe Brito Timbó
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0106 biological sciences ,medicine.medical_specialty ,Scale (ratio) ,Stroke patient ,Computer science ,medicine.disease ,01 natural sciences ,03 medical and health sciences ,0302 clinical medicine ,Physical medicine and rehabilitation ,Automated algorithm ,010608 biotechnology ,Original Research Articles ,medicine ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,Stroke ,030217 neurology & neurosurgery - Abstract
Introduction The Oxfordshire Community Stroke Project (OCSP) proposed a clinical classification for Stroke patients. This classification has proved helpful to predict the risk of neurological complications. However, the OCSP was initially based on findings on the neurological assesment, which can pose difficulties for classifying patients. We aimed to describe the development and the validation step of a computer-based algorithm based on the OCSP classification. Materials and methods A flow-chart was created which was reviewed by five board-certified vascular neurologists from which a computer-based algorithm (COMPACT) was developed. Neurology residents from 12 centers were invited to participate in a randomized trial to assess the effect of using COMPACT. They answered a 20-item questionnaire for classifying the vignettes according to the OCSP classification. Each correct answer has been attributed to 1-point for calculating the final score. Results Six-two participants agreed to participate and answered the questionnaire. Thirty-two were randomly allocated to use our algorithm, and thirty were allocated to adopt a list of symptoms alone. The group who adopted our algorithm had a median score of correct answers of 16.5[14.5, 17]/20 versus 15[13, 16]/20 points, p = 0.014. The use of our algorithm was associated with the overall rate of correct scores (p = 0.03). Discussion Our algorithm seemed a useful tool for any postgraduate year Neurology resident. A computer-based algorithm may save time and improve the accuracy to classify these patients. Conclusion An easy-to-use computer-based algorithm improved the accuracy of the OCSP classification, with the possible benefit of further improvement of the prediction of neurological complications and prognostication.
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- 2020
7. New species of Protaxodioxylon (conifer wood) from the Middle Permian of the Metangula Graben (Niassa Province, Mozambique) and their implications
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Ricardo Araújo, N. Nhamutole, and M. Bamford
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Graben ,Paleontology ,Paleozoic ,Permian ,Genus ,Fossil wood ,Biological dispersal ,Geology ,Mesozoic ,Cretaceous ,Earth-Surface Processes - Abstract
We describe for the first time in precise anatomical detail new occurrences of petrified woods in the K5 formation of the Metangula Graben (Niassa, northern Mozambique), pertaining to the Capitanian (mid Permian). The two new species of fossil wood are described from two very well-preserved specimens. The two new species, Protaxodioxylon verniersii sp. nov. and Protaxodioxylon metangulense sp. nov. are characterized by showing tracheids with mixed radial pitting and taxodioid pits in the cross-field, typical of the genus Protaxodioxylon. The specimens described are mostly distinguishable from other Protaxodioxylon species by the absence of axial parenchyma, the height of rays and the number of pits per cross-field. Protaxodioxylon species reported to date were mostly restricted to the Northern Hemisphere and to the late Mesozoic (Jurassic and Cretaceous). Surprisingly, however, this study infers that this fossil wood genus has a significantly longer time range than previously thought and underwent dispersal and diversification even earlier during the Palaeozoic . Additionally, both specimens display distinct growth rings indicating that the fossil woods grew in an environment controlled by seasonal variation with partial suspension of growth in times of less water availability and/or lower temperature. On the other hand, the occurrence of Protaxodioxylon suggest a humid temperate, warm subtropical climate condition during the Capitanian in the Metangula Graben.
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- 2021
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8. Diabetes-related major lower limb amputation incidence is strongly related to diabetic foot service provision and improves with enhancement of services: peer review of the South-West of England
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M Bamford, R Levenson, A Abbott, A Harrington, D Browne, M Roe, Richard B Paisey, and J Moore
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Service (business) ,medicine.medical_specialty ,business.industry ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Incidence (epidemiology) ,Podiatry ,030209 endocrinology & metabolism ,medicine.disease ,Diabetic foot ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Amputation ,Internal Medicine ,Physical therapy ,Medicine ,030212 general & internal medicine ,Disease management (health) ,business ,Foot (unit) - Abstract
Aims To investigate the relationship between high diabetes-related lower limb amputation incidence and foot care services in the South-West region of England. Methods The introduction of 10 key elements of foot care service provision in one area of the South-West resulted in stabilization of foot ulcer incidence and sustained reduction in amputation incidence from 2007. Services introduced included administrative support, standardized general practice foot screening, improved community podiatry staffing, hospital multidisciplinary foot clinics, effective care pathways, availability of an orthotist and audit. Peer reviews of the region's diabetes foot care services were undertaken to assess delivery of these service provisions and compare this with major amputation incidence in other regions with data provided by Yorkshire and Humber Public Health Observatory Hospital Episode Statistics. Recommendations were made to improve service provision. In 2015 changes in service provision and amputation incidence were reviewed. Results Initial reviews in 2013 showed that the 3-year diabetes-related major amputation incidence correlated inversely with adequate delivery of diabetes foot care services (P=0.0024, adjusted R2 =0.51). Repeat reviews in 2015 found that two or more foot care service improvements were reported by six diabetes foot care providers, with improvement in outcomes. The negative relationship between major amputation incidence and service provision remained strong both in the period 2012–2015 and in the year 2015 only (P ≤0.0012, adjusted R2 =0.56, and P= 0.0005, R2=0.62, respectively). Conclusions Major diabetes-related lower limb amputation incidence is significantly inversely correlated with foot care services provision. Introduction of more effective service provision resulted in significant reductions in major amputation incidence within 2 years. Failure to improve unsatisfactory service provision resulted in continued high amputation incidence.
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- 2017
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9. The cost-effectiveness of magnetic resonance angiography for carotid artery stenosis and peripheral vascular disease: a systematic review
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E. Berry, S. Kelly, M. E. Westwood, L. M. Davies, M. J. Gough, J. M. Bamford, J. F. M. Meaney, C. M. Airey, J. Cullingworth, M. Barbieri, A. Jackson, and M. A. Smith
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Medical technology ,R855-855.5 - Published
- 2002
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10. PIXE micro-mapping of minor elements in Hypatia, a diamond bearing carbonaceous stone from the Libyan Desert Glass area, Egypt: Inheritance from a cold molecular cloud?
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Jolanta Mesjasz-Przybyłowicz, M. Bamford, G.A. Belyanin, Wojciech J. Przybyłowicz, Jan Kramers, A. Venter, J.E. Westraadt, and Marco A.G. Andreoli
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Nuclear and High Energy Physics ,Materials science ,Meteorite ,Molecular cloud ,Mineralogy ,A diamond ,Libyan desert glass ,Lithophile ,Poor correlation ,Platinum group ,Pebble ,Instrumentation - Abstract
Matter originating from space, particularly if it represents rare meteorite samples, is ideally suited to be studied by Particle Induced X-ray Emission (PIXE) as this analytical technique covers a broad range of trace elements and is per se non-destructive. We describe and interpret a set of micro-PIXE elemental maps obtained on two minute (weighing about 25 and 150 mg), highly polished fragments taken from Hypatia, a controversial, diamond-bearing carbonaceous pebble from the SW Egyptian desert. PIXE data show that Hypatia is chemically heterogeneous, with significant amounts of primordial S, Cl, P and at least 10 elements with Z > 21 (Ti, V, Cr, Mn, Fe, Ni, Os, Ir) locally attaining concentrations above 500 ppm. Si, Al, Ca, K, O also occur, but are predominantly confined to cracks and likely represent contamination from the desert environment. Unusual in the stone is poor correlation between elements within the chalcophile (S vs. Cu, Zn) and siderophile (i.e.: Fe vs. Ni, Ir, Os) groups, whereas other siderophiles (Mn, Mo and the Platinum group elements (PGEs)) mimic the distribution of lithophile elements such as Cr and V. Worthy of mention is also the presence of a globular domain (O ∼ 120 μm) that is C and metals-depleted, yet Cl (P)-enriched (>3 wt.% and 0.15 wt.% respectively). While the host of the Cl remains undetermined, this chemical unit is enclosed within a broader domain that is similarly C-poor, yet Cr–Ir rich (up to 1.2 and 0.3 wt.% respectively). Our data suggest that the pebble consists of shock-compacted, primitive carbonaceous material enriched in cold, pre-solar dust.
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- 2015
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11. Cognitive bias modification as a strategy to reduce children's fears and concerns about the secondary school transition
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Petrina Cox, Gillian M Bamford, and Jennifer Y. F. Lau
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Male ,050103 clinical psychology ,Cognitive bias modification ,Psychological intervention ,Developmental psychology ,Cognition ,Arts and Humanities (miscellaneous) ,Intervention (counseling) ,Developmental and Educational Psychology ,medicine ,Humans ,0501 psychology and cognitive sciences ,Child ,Students ,Schools ,Cognitive Behavioral Therapy ,Transition (fiction) ,05 social sciences ,Stressor ,Fear ,Active control ,United Kingdom ,Psychiatry and Mental health ,Clinical Psychology ,Anxiety ,Female ,medicine.symptom ,Psychology ,Stress, Psychological ,050104 developmental & child psychology ,Clinical psychology ,Cognitive style - Abstract
Cognitive Bias Modification of Interpretations (CBM-I) has emerged as an anxiety-reducing tool for children and adolescents, targeting maladaptive interpretations of everyday situations. This literature falls short of addressing whether the effects of CBM-I extend to worries about a real-life stressor, such as a school transition.The study comprised a between-groups design comparing the effects of CBM-I to an active control (AC) intervention in children.We recruited 38 children within two months of their primary-secondary school transition and investigated the capacity for multi-session, parent-administered CBM-I, compared to an AC condition, to modify cognitive style and reduce anxiety symptoms and school concerns.While benign interpretations increased significantly and negative interpretations tended to decrease following CBM-I, both interventions significantly reduced anxiety symptoms and school concerns.These findings indicate that anxiety-reducing effects of CBM-I in children extend to a real life stressful event, but that equivalent anxiety reduction may be achieved through exposure to potentially worrying situations and parent-child interaction in the absence of bias modification.
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- 2015
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12. Intravascular basal cell carcinoma: what to do next?
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A. Sharma, Sandeep Varma, D. J. McKenna, M. Bamford, Somaia Elsheikh, and D. Veitch
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Pathology ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Dermatology ,Cheek ,medicine.disease ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Text mining ,medicine.anatomical_structure ,Neoplasm Invasiveness ,030220 oncology & carcinogenesis ,Mohs surgery ,Carcinoma ,Medicine ,Basal cell carcinoma ,business - Published
- 2018
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13. 5-Hydroxymethylcytosine is an independent predictor of survival in malignant melanoma
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Kathryn P. Lawes, Kah Wee Teo, Farhaan Moosa, J. Howard Pringle, M. Bamford, Kushal Joshi, and Gerald Saldanha
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0301 basic medicine ,Male ,Pathology ,medicine.medical_specialty ,Skin Neoplasms ,Article ,Pathology and Forensic Medicine ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Stage (cooking) ,Survival rate ,Melanoma ,Cancer staging ,Aged ,Neoplasm Staging ,Retrospective Studies ,Skin ,business.industry ,Proportional hazards model ,Hazard ratio ,Age Factors ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Prognosis ,Survival Rate ,030104 developmental biology ,030220 oncology & carcinogenesis ,5-Methylcytosine ,Biomarker (medicine) ,Female ,business - Abstract
Outcomes for melanoma patients vary within cancer stage. Prognostic biomarkers are potential adjuncts to provide more precise prognostic information. Simple, low-cost biomarker assays, such as those based on immunohistochemistry, have strong translational potential. 5-hydroxymethylcytosine (5 hmC) shows prognostic potential in melanoma but prior studies were small. We, therefore, analysed 5 hmC in a retrospective cohort to provide external validation of its prognostic value. Two hundred primary melanomas were evaluated for 5 hmC expression using immunohistochemistry. The primary objective was to assess the effect on overall survival while controlling for important confounders. Univariable and multivariable analyses were performed. REMARK guidelines were followed. The 5 hmC immunohistochemistry scoring showed very strong inter-observer agreement (ICC 0.88) and expression was significantly related to age, site, Breslow thickness, ulceration, mitotic rate, and stage. Kaplan–Meier analysis showed 5 hmC was associated with metastasis-free, melanoma-specific, and overall survival, P
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- 2016
14. 5 Years review of periocular basal cell carcinoma and proposed follow-up protocol
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Joyce Burns, S F Ho, M Bamford, L Brown, and Raghavan Sampath
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Adult ,Male ,medicine.medical_specialty ,Skin Neoplasms ,Eyelid Neoplasms ,Cohort Studies ,Risk Factors ,Surveys and Questionnaires ,Humans ,Medicine ,Basal cell carcinoma ,Aged ,Retrospective Studies ,Aged, 80 and over ,integumentary system ,business.industry ,Incidence (epidemiology) ,Retrospective cohort study ,Histology ,Middle Aged ,Eyelid Neoplasm ,medicine.disease ,United Kingdom ,Surgery ,Ophthalmology ,medicine.anatomical_structure ,Carcinoma, Basal Cell ,Clinical Study ,Female ,Case note ,Eyelid ,Neoplasm Recurrence, Local ,business ,Cohort study - Abstract
(1) To investigate the recurrence of periocular basal cell carcinoma (BCC) reported as completely excised on histology. (2) To identify risks associated with recurrence. (3) To recommend a rational follow-up protocol. This is a cohort study by case note review of consecutive patients undergoing excision of periocular BCC between 2000 and 2006 at University Hospitals of Leicester. All lesions were excised with 3 mm clinical margin and the defect reconstructed only after the excision margin was declared clear. A total of 413 episodes of surgical excision were recorded for 270 patients over the 7-year period of 2000–2006. All of them have 5 years follow-up. Mean age 73.7 (±12.5). In all, 67% were nodular BCC and 45.4% located in the lower eyelid. The main outcome measure was the recurrence rate. None of the patients with primary nodular BCC suffered recurrence. The recurrence rate for primary morphoeaform BCC following complete excision is 3.8%. In total, 8.1% of patients had several lesions simultaneously whereas 7.8% patients had BCC in multiple locations subsequently (metachronous). Three patients who had previously recurrent BCC (rBCC) treated elsewhere or not using this method had orbital/lacrimal drainage system involvement requiring exenteration. We recommend that patients with a single, completely excised primary solid or nodular BCC can be discharged after one 6-monthly review, although they should be instructed to monitor for the development of further lesions. The incidence of recurrence for primary morphoeaform BCC is 3.8% and for rBCC is 3.6% over 5 years and these patients should stay under review for this period.
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- 2012
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15. Randomized, double-blind trial of 220 mg zinc sulfate twice daily in the treatment of rosacea
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Irina V. Haller, Charles E. Gessert, Kim Kruger, Joel T. M. Bamford, and Brian Johnson
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medicine.medical_specialty ,Serum zinc ,business.industry ,chemistry.chemical_element ,Dermatology ,Zinc ,medicine.disease ,Placebo ,Gastroenterology ,law.invention ,Double blind ,Randomized controlled trial ,chemistry ,Rosacea ,law ,Internal medicine ,Severity of illness ,medicine ,In patient ,business - Abstract
A 2006 article published in the International Journal of Dermatology reported that oral zinc sulfate 100 mg three times daily was associated with improvement in the severity of facial rosacea (Sharquie et al. 2006; 45: 857-861). The current study was undertaken to further assess the role of zinc in the management of rosacea. This was a randomized, double-blind trial of 220 mg of zinc sulfate twice daily for 90 days in patients with moderately severe facial rosacea at baseline. Subjects were recruited in the Upper Midwest USA between August 2006 and April 2008, and followed until July 2008. Forty-four subjects completed the trial (22 in each arm). Rosacea improved in both groups. There were no differences in magnitude of improvement based on rosacea severity scores between subjects receiving zinc sulfate and subjects receiving placebo (P=0.284). Serum zinc levels were higher in subjects receiving zinc (P
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- 2012
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16. Work and Health : An Introduction to Occupational Health Care
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M. Bamford and M. Bamford
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- Medicine, Preventive, Health promotion, Quality of life
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- 2013
17. Measuring the severity of rosacea: a review
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Charles E. Gessert and Joel T. M. Bamford
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medicine.medical_specialty ,Erythema ,business.industry ,MEDLINE ,Signs and symptoms ,Dermatology ,medicine.disease ,Severity of Illness Index ,Clinical trial ,Rosacea ,Severity of illness ,Humans ,Medicine ,medicine.symptom ,business ,Telangiectasia ,Medical literature - Abstract
Background Assessment of severity is essential in the clinical care of rosacea patients and in the research on rosacea. Objective To determine the range of methods used to assess rosacea severity in clinical trials. Methods The medical literature from 1965 through 2001 was searched for rosacea clinical trials using MEDLINE and published citations. Forty-seven articles were reviewed. Results The most frequently assessed signs of rosacea were papules/pustules (43 studies), erythema (35), and telangiectasia (24). Other signs and symptoms of rosacea and adverse reactions to therapies were assessed in 27 studies. Counts of papules/pustules were conducted in 34 studies. Four-point scales were the most frequently used assessment tools for erythema (17) and telangiectasia (11). Other frequently used techniques included global assessment by clinicians (29) and by patients (21), and photography (13). Conclusions At present, there are no standard validated tools for assessing the severity of rosacea or its signs or symptoms.
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- 2003
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18. The development and evaluation of the UK national telepathology network
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W M Bamford, M Kassam, J Rashbass, Peter N. Furness, and N Rogers
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Telemedicine ,Government ,Pathology ,medicine.medical_specialty ,Histology ,business.product_category ,business.industry ,Internet privacy ,Information technology ,Workload ,General Medicine ,computer.software_genre ,Pathology and Forensic Medicine ,Videoconferencing ,Server ,Internet access ,Medicine ,business ,Telepathology ,computer - Abstract
Aims: As technology advances and costs fall, it may be anticipated that soon every histopathologist will expect to be able to exchange electronic images with colleagues. Arguing that the value of a network increases as more people are connected, we sought to install a simple, low-cost telepathology system into any histopathology laboratory which requested it within the UK. Methods and results: We assumed that laboratories had microscopes, computers and internet access. We offered low-cost video cameras, video input cards, software and training to any histopathology department requesting installation, limited only by resources supplied by the UK government. We also established central servers and a website with ‘help’ files. After 1 year we studied system use and pathologists' opinions by circulating a questionnaire. Installations were completed in 35 laboratories; there are currently 66 registered users of the system, with 16 identified ‘experts’ covering most organ systems. Serious difficulties were caused by institutional firewalls and reluctance of local information technology (IT) staff to make changes to facilitate the installation or to help resolve subsequent network problems. After installation, many of the telepathology systems remain unused. Concerns were expressed about image quality, though mainly by pathologists who had not used the system for diagnostic work. The system remains available, but the level of use is low. Conclusions: This project has not achieved its aims. The reasons are complex, but mainly relate to human attitudes. Pathologists with excessive workloads were reluctant to use time to learn new skills which were not directed to reducing workload. IT staff did not perceive the project as part of their routine work. There were also numerous technological problems, but although image quality was cited by many, it was not a complaint of those who actively used the system. These problems have not been encountered by previous projects which involved small groups of committed enthusiasts.
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- 2003
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19. Hearing-impaired children in the UK: education setting and communication approach
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Heather M. Fortnum, David H. Marshall, John M. Bamford, and A. Quentin Summerfield
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Speech and Hearing ,Education - Published
- 2002
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20. Stroke after internal jugular venous cannulation
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J. M. Bamford, M. D. D. Bell, E. P. L. Turton, L. A. Dunkley, and Markus Reuber
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medicine.medical_specialty ,business.industry ,Vascular disease ,Ultrasound ,General Medicine ,medicine.disease ,Surgery ,Central nervous system disease ,Neurology ,Anesthesia ,Medicine ,cardiovascular diseases ,Neurology (clinical) ,Thrombus ,Complication ,business ,Stroke ,Internal jugular vein ,Venous cannulation - Abstract
Objective - To alert clinicians to the stroke risk associated with carotid artery injury secondary to attempted internal jugular venous (IJV) cannulation. Methods - Case reports and review of the literature. Results - Four patients developed a stroke following carotid artery (CA) injury during attempted IJV cannulation using the landmark technique. In all cases the arterial puncture was detected immediately and firm pressure applied for several minutes. In three cases there was evidence of intimal injury and thrombus formation. Two strokes were delayed by more than 24 h. One patient died. A review of studies describing 4487 IJV line insertion attempts using the landmark technique reveals that 5.9% of attempts are associated with CA injury. Conclusion - Cannulation of the IJV using visible and palpable landmarks is associated with a risk of stroke. Arterial injury and stroke should be mentioned when consent is obtained for cannulation. Consideration should be given to a reduction of the arterial injury risk by using ultrasound guidance during line insertion.
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- 2002
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21. Progressive widespread asymptomatic telangiectases
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Karen E. Harman, G. Saldhana, V. R. Sim, P. DeMozzi, and M. Bamford
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Adult ,Foot Dermatoses ,medicine.medical_specialty ,business.industry ,Dermatology ,Telangiectases ,Leg Dermatoses ,Asymptomatic ,Surgery ,Diagnosis, Differential ,medicine ,Humans ,Female ,Telangiectasis ,medicine.symptom ,business - Published
- 2014
22. Intravascular tumour in intraoral pleomorphic adenomas
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C H Kendall and M Bamford
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Pathology ,medicine.medical_specialty ,Histology ,business.industry ,medicine ,General Medicine ,business ,Pathology and Forensic Medicine - Published
- 2000
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23. Naphthyl ketones: a new class of Janus kinase 3 inhibitors
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Neil Rankine, Andrea M. Bamford, Daniel S. James, Vanessa Torr, Brown George Robert, Jonathan Bowyer, Eric J. Culbert, and Eric Tang
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Ketone ,Stereochemistry ,medicine.drug_class ,Clinical Biochemistry ,Pharmaceutical Science ,Enzyme-Linked Immunosorbent Assay ,Naphthalenes ,Biochemistry ,Chemical synthesis ,Aminoketone ,Mannich Bases ,Structure-Activity Relationship ,chemistry.chemical_compound ,Drug Discovery ,medicine ,Humans ,Structure–activity relationship ,Enzyme Inhibitors ,Molecular Biology ,chemistry.chemical_classification ,biology ,Janus kinase 3 ,Organic Chemistry ,Janus Kinase 3 ,Ketones ,Protein-Tyrosine Kinases ,chemistry ,Enzyme inhibitor ,biology.protein ,Molecular Medicine ,Indicators and Reagents ,Enone ,Tyrosine kinase - Abstract
Potent inhibition of Janus kinase 3 was found for a series of naphthyl(beta-aminoethyl)ketones (e.g. 7, pIC50 = 7.1+/-0.3). Further studies indicated that these compounds fragment in less than 1 h by retro-Michael reaction in the Jak3 in vitro ELISA assay procedure. The breakdown product of 7, 2-naphthylvinyl ketone (22, pIC50 = 6.8+/-0.3) showed very similar inhibitory activity to 7. Compounds 7 (in neutral buffer) and 22 will be useful pharmacological tools for the investigation of the Janus tyrosine kinase Jak3.
- Published
- 2000
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24. The interface between TiAlN hard coatings and steel substrates generated by high energetic Cr+ bombardment
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M. Bamford, C. Schönjahn, D.B. Lewis, Susan D. Forder, Wolf-Dieter Münz, and L.A. Donohue
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Materials science ,Metallurgy ,Sputter cleaning ,Biasing ,Surfaces and Interfaces ,General Chemistry ,Substrate (electronics) ,Condensed Matter Physics ,Epitaxy ,Surfaces, Coatings and Films ,Conversion electron mössbauer spectroscopy ,Sputtering ,Physical vapor deposition ,Cavity magnetron ,Materials Chemistry - Abstract
The microstructure of TiAlN coatings deposited by reactive unbalanced magnetron (UBM) sputtering after substrate bombardment with Cr ions, generated by a cathodic arc, and compositional changes of the ferritic steel substrate have been investigated for different bias voltages ( U b ) during the Cr bombardment. Analysis was carried out using cross-sectional transmission electron microscopy (XTEM) and conversion electron Mossbauer spectroscopy (CEMS). The aim of the Cr bombardment is a substrate sputter cleaning effect. This is achieved when a bias voltage of −1200 V is applied. In this case subsequent UBM deposition of TiAlN leads to the growth of dense coatings exhibiting local epitaxy. For lower bias voltages CEMS indicates Cr deposition resulting in an open columnar structure of the subsequently grown TiAlN film, although small areas with oriented growth can still be observed.
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- 2000
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25. Polymorphisms of the Factor VII Gene and Circulating FVII:C Levels in Relation to Acute Cerebrovascular Disease and Poststroke Mortality
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John M. Bamford, Angela M. Carter, D. M. Heywood, Peter J. Grant, and Andrew J. Catto
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Male ,medicine.medical_specialty ,Genotype ,Polymorphism (biology) ,Gastroenterology ,Central nervous system disease ,chemistry.chemical_compound ,hemic and lymphatic diseases ,Internal medicine ,medicine ,Humans ,cardiovascular diseases ,Myocardial infarction ,Antigens ,Risk factor ,Stroke ,Aged ,Advanced and Specialized Nursing ,Sex Characteristics ,Polymorphism, Genetic ,Factor VII ,Vascular disease ,business.industry ,Middle Aged ,medicine.disease ,Confidence interval ,Surgery ,Cerebrovascular Disorders ,Cholesterol ,Genes ,chemistry ,Acute Disease ,DNA Transposable Elements ,Female ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background and Purpose FVII:C has been shown to be an independent risk factor for myocardial infarction and is related to environmental and genetic factors. This study sought to investigate FVII:C levels and factor VII (FVII) gene polymorphisms in relation to stroke and disease outcome. Methods To examine the association of FVII:C and the Msp I and promoter insertion polymorphisms of the FVII gene in acute stroke, 317 patients and 198 age-matched control subjects were studied. Results FVII:C levels were significantly lower in patients at onset than 3 months later (119% versus 135%, respectively; P P Msp I genotype, cholesterol, and smoking remained as independent predictors of FVII:C levels, accounting for 32% of interindividual variation. Conclusions These results suggest that neither FVII:C levels nor FVII gene polymorphisms are associated with cerebrovascular disease. There were no genotype-specific correlations of environmental factors with FVII:C, but there was evidence of an acute-phase or consumptive fall in FVII:C levels at the time of stroke, whereas levels increased to those similar for healthy age-matched control subjects by 3 months, when the acute phase had presumably subsided.
- Published
- 1997
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26. Factor XIII—circulating levels and Val34Leu polymorphism in relatives of South Asian patients with ischemic stroke
- Author
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John Young, John M. Bamford, John Bavington, Andrew J. Catto, and Kevin C. Kain
- Subjects
Adult ,Male ,medicine.medical_specialty ,Asia ,South asia ,Adolescent ,Genotype ,Polymerase Chain Reaction ,Gastroenterology ,Ischemia ,Leucine ,Polymorphism (computer science) ,Internal medicine ,medicine ,Humans ,Aged ,Aged, 80 and over ,Polymorphism, Genetic ,Factor XIII ,business.industry ,Valine ,Hematology ,Middle Aged ,Stroke ,Ischemic stroke ,Female ,business ,medicine.drug - Published
- 2005
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- View/download PDF
27. A cutaneous presentation of a rare condition
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Graham A. Johnston, Sarah Rasool, and M. Bamford
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medicine.medical_specialty ,business.industry ,media_common.quotation_subject ,Dermatology ,Skin Diseases ,Presentation ,Histiocytosis, Langerhans-Cell ,Text mining ,Rare Diseases ,Medicine ,Humans ,Female ,business ,Genital Diseases, Female ,media_common ,Aged - Published
- 2013
28. Synthesis of 5-acetylamino-4-[11C]guanidino-2,6-anhydro-3,4,5-trideoxy-D-glycero-D-galacto-non-2-enoic acid ([11C]GG167)-an influenza virus neuraminidase inhibitor
- Author
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M. Bamford, M.J. Daniel, Bengt Långström, Göran Westerberg, and Derek R. Sutherland
- Subjects
chemistry.chemical_classification ,biology ,Neuraminidase inhibitor ,Stereochemistry ,medicine.drug_class ,Organic Chemistry ,Orthomyxoviridae ,biology.organism_classification ,Biochemistry ,Chemical synthesis ,Virus ,Analytical Chemistry ,chemistry.chemical_compound ,Enzyme ,chemistry ,Enzyme inhibitor ,Drug Discovery ,Aldonic acid ,biology.protein ,medicine ,Radiology, Nuclear Medicine and imaging ,Cyanogen bromide ,Spectroscopy - Abstract
The novel influenza virus neuraminidase inhibitor GG167 (5-acetylamino-4-guanidino-2,6-anhydro-3,4,5-trideoxy-D-glycero-D-galacto-non-2-enoic acid) was labelled with 11 C for use in positron emission tomographic studies of drug deposition following intranasal or inhaled administration. [ 11 C]GG167 was obtained within a synthesis time of 50min via a two-step procedure, starting from [ 11 C]cyanogen bromide.
- Published
- 1996
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- View/download PDF
29. Acrokeratosis paraneoplastica associated with recurrent metastatic thymic carcinoma
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T.A. Chave, Karen E. Harman, and W. M. Bamford
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Pathology ,medicine.medical_specialty ,Thymoma ,Keratosis ,business.industry ,Metastatic thymic carcinoma ,Acrodermatitis ,Medicine ,Dermatology ,Acrokeratosis paraneoplastica ,business ,medicine.disease - Published
- 2004
- Full Text
- View/download PDF
30. Yellow Marker Tuff, Laetoli: A geological study
- Author
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S. Mavuso and M. Bamford
- Subjects
Geochemistry ,Geomorphology ,Geology ,Earth-Surface Processes - Published
- 2016
- Full Text
- View/download PDF
31. Gender differences in coagulation and fibrinolysis in white subjects with acute ischemic stroke
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Andrew J. Catto, Kirti Kain, Angela M. Carter, John M. Bamford, and Peter J. Grant
- Subjects
medicine.medical_specialty ,White (horse) ,business.industry ,medicine.medical_treatment ,Case-control study ,Hematology ,Coagulation ,Internal medicine ,Fibrinolysis ,Cardiology ,Medicine ,business ,Acute ischemic stroke ,Sex characteristics - Published
- 2003
- Full Text
- View/download PDF
32. A girl with multiple asymptomatic pigmented macules and patches
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I, Helbling, W M, Bamford, and S M, Taibjee
- Subjects
Diagnosis, Differential ,Nevus, Pigmented ,Skin Neoplasms ,Papilloma ,Humans ,Female ,Child ,Pigmentation Disorders - Published
- 2012
33. Randomized, double-blind trial of 220 mg zinc sulfate twice daily in the treatment of rosacea
- Author
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Joel T M, Bamford, Charles E, Gessert, Irina V, Haller, Kim, Kruger, and Brian P, Johnson
- Subjects
Adult ,Male ,Administration, Oral ,Middle Aged ,Severity of Illness Index ,Zinc Sulfate ,Zinc ,Treatment Outcome ,Double-Blind Method ,Rosacea ,Quality of Life ,Humans ,Female ,Astringents - Abstract
A 2006 article published in the International Journal of Dermatology reported that oral zinc sulfate 100 mg three times daily was associated with improvement in the severity of facial rosacea (Sharquie et al. 2006; 45: 857-861). The current study was undertaken to further assess the role of zinc in the management of rosacea. This was a randomized, double-blind trial of 220 mg of zinc sulfate twice daily for 90 days in patients with moderately severe facial rosacea at baseline. Subjects were recruited in the Upper Midwest USA between August 2006 and April 2008, and followed until July 2008. Forty-four subjects completed the trial (22 in each arm). Rosacea improved in both groups. There were no differences in magnitude of improvement based on rosacea severity scores between subjects receiving zinc sulfate and subjects receiving placebo (P=0.284). Serum zinc levels were higher in subjects receiving zinc (P0.001). Oral zinc sulfate was not associated with greater improvement in rosacea severity compared with placebo in this study. Additional studies are needed to determine what role oral zinc may have in the management of rosacea.
- Published
- 2012
34. What causes false clinical prediction of small deep infarcts?
- Author
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J. M. Bamford, J Boiten, J Kappelle, and Jan Lodder
- Subjects
Male ,medicine.medical_specialty ,Asymptomatic ,Lesion ,Central nervous system disease ,Disability Evaluation ,Modified Rankin Scale ,Aphasia ,medicine ,Humans ,Prospective Studies ,cardiovascular diseases ,Diagnostic Errors ,Aged ,Advanced and Specialized Nursing ,Movement Disorders ,Vascular disease ,business.industry ,Cerebral infarction ,Coronary Thrombosis ,Leukoaraiosis ,Cerebral Infarction ,Odds ratio ,medicine.disease ,Surgery ,Sensation Disorders ,Female ,Neurology (clinical) ,Radiology ,medicine.symptom ,Tomography, X-Ray Computed ,Cardiology and Cardiovascular Medicine ,business - Abstract
Our goal was to identify factors that play a role in false clinical diagnosis of small deep infarcts. In 350 prospectively registered patients with a first supratentorial ischemic stroke, we clinically differentiated between lacunar and nonlacunar syndromes. Using computed tomography (CT), we distinguished small deep and territorial infarcts and also recorded leukoaraiosis and asymptomatic infarcts. Degree of initial handicap, potential source of cardioembolic stroke, and hypertension were also noted. One hundred forty-seven patients had a lacunar and 203 a nonlacunar syndrome. Forty-two (12%) had a lesion visualized by CT that was compatible with a recent infarct but was considered inappropriate for the clinical syndrome: nineteen had a nonlacunar syndrome but a small deep infarct, and 23 had a lacunar syndrome but a territorial infarct. Patients with a nonlacunar syndrome but a small deep infarct were more severely disabled (a modified Rankin scale rating of 5) (odds ratio [OR], 4.31; 95% confidence interval [CI], 1.25 to 14.88) and had a cardioembolic source (OR, 4.07; 95% CI, 1.04 to 15.95), leukoaraiosis (OR, 3.79; 95% CI, 1.32 to 10.05), or asymptomatic infarcts visualized by CT (OR, 4.13; 95% CI, 1.45 to 11.71) compared with 124 patients with a correctly diagnosed small deep infarct. Twelve of 19 patients with a nonlacunar syndrome but a small deep infarct had a lesion in the left hemisphere, and 9 of these 12 had "aphasia." Patients with a lacunar syndrome but a territorial infarct more often had a cardioembolic source (OR, 4.02; 95% CI, 1.15 to 14.03) and a pure motor syndrome (OR, 4.52; 95% CI, 1.55 to 13.18) than those with lacunar syndrome but a small deep infarct, although 21 (91%) were in the right hemisphere. Of the first 103 patients with lacunar stroke diagnosed by two of the study neurologists, 5 had an inappropriate lesion compared with 14 of the later 40 diagnosed by colleagues without a specific interest in cerebrovascular diseases (OR, 0.09; 95% CI, 0.03 to 0.26). (1) Diagnosis of lacunar syndromes should not be influenced by deficit severity or the presence of a potential cardiac source of embolism. (2) Speech disorders should carefully be classified. (3) Routine tests of nondominant higher functions may be inadequate. (4) Doctors interested in cerebrovascular neurology have a lower failure rate in differentiating small deep infarcts from territorial infarcts than those less well-trained or interested in neurology. (5) Among the lacunar syndromes, pure motor syndrome may be the least specific predictor of a small deep infarct.
- Published
- 1994
- Full Text
- View/download PDF
35. Thyroliberin-induced changes in the fluorescence of a membrane probe in individual bovine anterior pituitary cells
- Author
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M. Bamford, S. L. Shorte, Sarah J. V. Stafford, J G Schofield, and Valerie J. Collett
- Subjects
Quinpirole ,Physiology ,Fluorescence spectrometry ,Analytical chemistry ,Annulus (botany) ,Exocytosis ,Prolactin cell ,Anterior pituitary ,Pituitary Gland, Anterior ,medicine ,Animals ,Ergolines ,Thyrotropin-Releasing Hormone ,Cells, Cultured ,Fluorescent Dyes ,Chemistry ,Cell Membrane ,Immunohistochemistry ,Fluorescence ,Prolactin ,Membrane ,medicine.anatomical_structure ,Microscopy, Fluorescence ,Biophysics ,Cattle ,Female ,Steady state (chemistry) ,Fura-2 ,Diphenylhexatriene ,Research Article - Abstract
1. We have investigated the use of TMA-DPH (1-[4-(trimethylammonio) phenyl]-6-phenylhexa-1,3,5-triene) as an indicator of exocytosis in individual bovine anterior pituitary cells using microfluorimetric imaging. 2. TMA-DPH was photolabile in artificial and cell membranes. In cells incubated in TMA-DPH the distribution of fluorescence depended both on the incubation time and the illumination schedule. If the dye was added while the cells were subjected to repeated cycles of 0.36 s light intermittent with 1-15 s dark, the fluorescence of the peripheral annulus and the central region of individual cells rose in parallel and reached a steady state within 200 s; the annulus was always brighter than the central region. However, using long intervening dark periods (200 s), the central region continued to incorporate dye after the annulus had reached a plateau. 3. When the cells were loaded with TMA-DPH using intermittent light with short dark periods, the dye washed out of the central region and the annulus in parallel when external dye was removed. However, if the cells had been loaded using long dark periods, the dye was washed out of the central region more slowly than from the annulus. 4. When cells were incubated in TMA-DPH in the dark for 1 min and then exposed to constant illumination in the presence of external dye, the fluorescence of the central region and the annulus both decayed in parallel to a new steady state. If the cells were incubated in TMA-DPH in the dark for 240 min the fluorescence from each region fell to a steady state but the falls were larger and were not in parallel. 5. We suggest that TMA-DPH fluorescence was derived from plasma membrane-associated and internalized dye and that the amount of fluorescence from the latter varied because TMA-DPH was photobleached. Thus, when illumination was interrupted by short dark intervals, annular fluorescence was high compared to central fluorescence because bleached dye in the plasma membrane was rapidly replaced by unbleached dye from the medium. However, long dark intervals permitted the dye to be internalized before it was bleached and fluorescence was therefore also present in central regions. 6. The total cell fluorescence, observed using 15 s dark intervals, was increased 5-40% (in single cells) in a dose-dependent fashion by addition of TRH (tripeptide thyrotrophin-releasing hormone; 1-200 nM).(ABSTRACT TRUNCATED AT 400 WORDS)
- Published
- 1993
- Full Text
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36. A rare case of primary apocrine carcinoma of the axilla
- Author
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R. Agarwal, M. Bamford, G. Saldanha, C. J. Lewis, and A. Deodhar
- Subjects
Axilla ,Plastic surgery ,medicine.medical_specialty ,medicine.anatomical_structure ,business.industry ,Rare case ,medicine ,Surgery ,Apocrine Carcinoma ,business ,Dermatology - Published
- 2014
- Full Text
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37. ChemInform Abstract: Naphthyl Ketones: A New Class of Janus Kinase 3 Inhibitors
- Author
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Jonathan Bowyer, Vanessa Torr, Daniel S. James, Neil Rankine, Eric Tang, Brown George Robert, Andrea M. Bamford, and Eric J. Culbert
- Subjects
chemistry.chemical_classification ,Ketone ,chemistry ,Stereochemistry ,Janus kinase 3 ,General Medicine ,Janus ,Elisa assay ,Tyrosine kinase ,In vitro - Abstract
Potent inhibition of Janus kinase 3 was found for a series of naphthyl(beta-aminoethyl)ketones (e.g. 7, pIC50 = 7.1+/-0.3). Further studies indicated that these compounds fragment in less than 1 h by retro-Michael reaction in the Jak3 in vitro ELISA assay procedure. The breakdown product of 7, 2-naphthylvinyl ketone (22, pIC50 = 6.8+/-0.3) showed very similar inhibitory activity to 7. Compounds 7 (in neutral buffer) and 22 will be useful pharmacological tools for the investigation of the Janus tyrosine kinase Jak3.
- Published
- 2010
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38. Principles of Horticulture
- Author
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C R Adams, M P Early, and K M Bamford
- Published
- 2008
- Full Text
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39. Transport in the plant
- Author
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K M Bamford
- Published
- 2008
- Full Text
- View/download PDF
40. Are hypertension or cardiac embolism likely causes of lacunar infarction?
- Author
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L. N. Jones, P. A. G. Sandercock, Jan Lodder, C. P. Warlow, and J. M. Bamford
- Subjects
Male ,medicine.medical_specialty ,Heart Diseases ,Heart disease ,Embolism ,Blood Pressure ,Internal medicine ,Prevalence ,medicine ,Humans ,Prospective Studies ,cardiovascular diseases ,Myocardial infarction ,Stroke ,Aged ,Advanced and Specialized Nursing ,Vascular disease ,Cerebral infarction ,business.industry ,Atrial fibrillation ,Cerebral Infarction ,Middle Aged ,medicine.disease ,Surgery ,Blood pressure ,Hypertension ,cardiovascular system ,Cardiology ,Female ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business - Abstract
We tested the hypothesis that hypertension is more common and cardiac embolism less common in patients with lacunar infarction than in patients with other types of cerebral infarction. We studied risk factor profiles in a series of 102 consecutive patients with a lacunar infarct and 202 consecutive patients with a carotid artery-distribution infarct involving the cortex registered in the Oxfordshire Community Stroke Project, a community-based study of first-ever stroke. The two groups did not differ in the prevalence of prestroke hypertension (defined in a number of ways) or in the prevalence of markers of sustained hypertension. The presence of atrial fibrillation and a history of myocardial infarction, particularly during the 6 weeks before the stroke, were significantly more common in the group with carotid-distribution infarcts involving the cortex. There was no significant difference in the prevalence of other accepted risk factors for ischemic stroke, including previous transient ischemic attack, cervical bruit, diabetes mellitus, peripheral vascular disease, or cigarette smoking. Our results suggest that hypertension is no more important in the development of lacunar infarction than it is in the development of other types of ischemic stroke that are presumed to be due to atherosclerotic thromboembolism in a major cerebral artery. Our data support the autopsy evidence that cardioembolic occlusion is an unusual cause of lacunar infarction.
- Published
- 1990
- Full Text
- View/download PDF
41. Botulinum toxin for adult spasticity after stroke or non-progressive brain lesion
- Author
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Bernadette E Lyons, Peter Moore, Bipin Bhakta, Ian D Logan, Christopher Cardwell, and John M Bamford
- Subjects
business.industry ,Anesthesia ,medicine ,Brain lesions ,Spasticity ,medicine.symptom ,medicine.disease ,business ,Stroke ,Botulinum toxin ,medicine.drug - Published
- 2007
- Full Text
- View/download PDF
42. The validity of the inclusion of 'lupus headache' in the Systemic Lupus Erythematosus Disease Activity Index
- Author
-
John M. Bamford, Paul Emery, and Richard Davey
- Subjects
Observer Variation ,medicine.medical_specialty ,business.industry ,Immunology ,Headache ,Reproducibility of Results ,Dermatology ,Severity of Illness Index ,Lupus headache ,Disease activity ,Rheumatology ,Immunology and Allergy ,Medicine ,Humans ,Lupus Erythematosus, Systemic ,Pharmacology (medical) ,medicine.symptom ,business ,Inclusion (education) ,Anti-SSA/Ro autoantibodies - Published
- 2007
43. Skin and bones
- Author
-
R. F. Davis, W. M. Bamford, and Graham A. Johnston
- Subjects
Male ,medicine.medical_specialty ,business.industry ,Infant ,Dermatology ,Fibrous Dysplasia, Polyostotic ,Bone and Bones ,Diagnosis, Differential ,Text mining ,Phenotype ,Skin Abnormalities ,Medicine ,Humans ,business - Published
- 2007
44. A venous ulcer on the hand secondary to an arteriovenous fistula for hemodialysis treated successfully by transvenous embolization
- Author
-
Sarah Rasool, Graham A. Johnston, and M. Bamford
- Subjects
medicine.medical_specialty ,business.industry ,Transvenous embolization ,medicine.medical_treatment ,Arteriovenous fistula ,Hand Dermatoses ,Middle Aged ,medicine.disease ,Embolization, Therapeutic ,Surgery ,Arteriovenous Shunt, Surgical ,Renal Dialysis ,Nephrology ,Skin Ulcer ,Humans ,Kidney Failure, Chronic ,Medicine ,Female ,Radiology ,Hemodialysis ,business - Published
- 2015
- Full Text
- View/download PDF
45. A patient with neuro-Behçet's disease is successfully treated with etanercept: further evidence for the value of TNFalpha blockade
- Author
-
John M. Bamford, Tanya Monaghan, and Jane E. Alty
- Subjects
musculoskeletal diseases ,Adult ,Azathioprine ,Receptors, Tumor Necrosis Factor ,Etanercept ,medicine ,Humans ,business.industry ,Tumor Necrosis Factor-alpha ,Behcet Syndrome ,Brain ,General Medicine ,medicine.disease ,Magnetic Resonance Imaging ,Infliximab ,Thalidomide ,stomatognathic diseases ,Immunoglobulin G ,Immunology ,Surgery ,Methotrexate ,Tumor necrosis factor alpha ,Female ,Neurology (clinical) ,Neuro-Behçet's disease ,Vasculitis ,business ,Immunosuppressive Agents ,medicine.drug - Abstract
Behçet's disease is a chronic relapsing multisystem vasculitis with 49% of cases involving the CNS. Recently there have been two reports of neuro-Behçet's disease (NB) successfully treated with the tumour necrosis factor alpha (TNFalpha) monoclonal antibody infliximab. We describe a patient with longstanding NB who was poorly responsive to azathioprine, cyclosporin, thalidomide and methotrexate. She showed a remarkable response when treated with the recombinant human TNFalpha receptor protein, etanercept. To the best of our knowledge this is the first report of NB successfully treated with etanercept.
- Published
- 2006
46. Detection of thermal bridges in insulating stratified media with thermography-a 2D transient direct model suitable to implement a Total Least Squares estimation method
- Author
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M. Bamford, J.C. Batsale, D. Mourand, and H. Bendada
- Published
- 2006
- Full Text
- View/download PDF
47. The role of zinc in rosacea and acne: further reflections
- Author
-
Charles E. Gessert, Joel T. M. Bamford, Irina V. Haller, and Brian Johnson
- Subjects
medicine.medical_specialty ,business.industry ,chemistry.chemical_element ,Dermatology ,Zinc ,medicine.disease ,Anti-Bacterial Agents ,chemistry ,Zinc Compounds ,Rosacea ,Acne Vulgaris ,Drug Resistance, Bacterial ,medicine ,Humans ,business ,Acne - Published
- 2013
- Full Text
- View/download PDF
48. A girl with multiple asymptomatic pigmented macules and patches
- Author
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W. M. Bamford, I. Helbling, and S. M. Taibjee
- Subjects
medicine.medical_specialty ,business.industry ,media_common.quotation_subject ,Medicine ,Dermatology ,Girl ,medicine.symptom ,business ,Asymptomatic ,media_common - Published
- 2012
- Full Text
- View/download PDF
49. How to undertake a clinically relevant systematic review in a rapidly evolving field. Magnetic resonance angiography
- Author
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Marie E, Westwood, Steven, Kelly, Elizabeth, Berry, John M, Bamford, Michael J, Gough, C Mark, Airey, Linda M, Davies, James F M, Meaney, Jane, Cullingworth, and Michael A, Smith
- Subjects
Evidence-Based Medicine ,Technology Assessment, Biomedical ,Meta-Analysis as Topic ,Cost-Benefit Analysis ,Data Collection ,Research ,Humans ,Databases, Bibliographic ,Magnetic Resonance Angiography ,United Kingdom - Abstract
The aim was to determine which generations of the evolving technology of magnetic resonance angiography (MRA) are currently of clinical relevance in two clinical applications. Our purpose was to plan a systematic review that would be valuable both to purchasers driven by cost-effectiveness and to practicing clinicians.Information was gathered from a search of major bibliographic databases, from a short questionnaire sent to 500 U.K. vascular radiologists and vascular surgeons, and from local clinical experts. We asked which of the MRA techniques were currently used and, assuming availability, what would be their technique of choice.There were 206 published articles that satisfied preliminary inclusion criteria: 69 discussed 2D time of flight (TOF); 47, 3D TOF; and 38, contrast-enhanced techniques. There were 162 questionnaires returned (60 radiologists, 102 surgeons). Of the total respondents, 77/162 (48%) used MRA in the assessment of carotid artery stenosis; 47/77 (61%) used 2D TOF; 32/77 (42%), 3D TOF; and 26/77 (34%), contrast-enhanced techniques. Thirty-five of 162 (22%) respondents used MRA in the assessment of peripheral vascular disease (PVD); 15/35 (43%) used 2D TOF, 4/35 (11%) used 3D TOF, and 22/35 (63%) used contrast-enhanced techniques. For those wishing to use MRA, contrast-enhanced techniques were the method of choice.The TOF methods that represent earlier generations of the technology remain clinically relevant, and will therefore be included in our systematic review. To ensure complete and relevant coverage in reviews of other evolving technologies, it would be advisable to obtain data for guidance in a similar way.
- Published
- 2002
50. Stroke after internal jugular venous cannulation
- Author
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M, Reuber, L A, Dunkley, E P L, Turton, M D D, Bell, and J M, Bamford
- Subjects
Adult ,Male ,Stroke ,Catheterization, Central Venous ,Carotid Arteries ,Postoperative Complications ,Risk Factors ,Humans ,Female ,Jugular Veins ,Aged - Abstract
To alert clinicians to the stroke risk associated with carotid artery injury secondary to attempted internal jugular venous (IJV) cannulation.Case reports and review of the literature.Four patients developed a stroke following carotid artery (CA) injury during attempted IJV cannulation using the landmark technique. In all cases the arterial puncture was detected immediately and firm pressure applied for several minutes. In three cases there was evidence of intimal injury and thrombus formation. Two strokes were delayed by more than 24 h. One patient died. A review of studies describing 4487 IJV line insertion attempts using the landmark technique reveals that 5.9% of attempts are associated with CA injury.Cannulation of the IJV using visible and palpable landmarks is associated with a risk of stroke. Arterial injury and stroke should be mentioned when consent is obtained for cannulation. Consideration should be given to a reduction of the arterial injury risk by using ultrasound guidance during line insertion.
- Published
- 2002
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