1. A Nosocomial Cluster of Candida inconspicua Infections in Patients with Hematological Malignancies
- Author
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F Schioppa, Ferdinando Romano, A. Mazzoni, T. Bonfini, Francesco D’Aloia, Beatrice Violante, Antonio Iacone, M. Assunta Capuani, and Domenico D'Antonio
- Subjects
Adult ,Male ,Microbiology (medical) ,Candida inconspicua ,Mycology ,Biology ,Disease Outbreaks ,Microbiology ,Immunocompromised Host ,Genotype ,medicine ,Cluster Analysis ,Humans ,Lymphoma, Follicular ,Fungemia ,Mycosis ,Candida ,Hepatitis ,Cross Infection ,Candidiasis ,Middle Aged ,medicine.disease ,Virology ,Leukemia, Myeloid, Acute ,DNA profiling ,Hematologic Neoplasms ,Female ,Restriction fragment length polymorphism ,Fluconazole ,medicine.drug - Abstract
Candida inconspicua was recovered from three patients with hematological malignancies. Two patients had intravenous-catheter-associated fungemia, whereas the third had fungal hepatitis. The three cases of infection occurred over a period of 1 month in patients staying in adjacent single rooms. In vitro susceptibility testing of fungal strains showed all isolates to be resistant to fluconazole, with MICs greater than 32 μg/ml. All of the strains had identical DNA restriction profiles and randomly amplified polymorphic DNA fingerprints. These data suggest a nosocomially acquired infection emanating from a common source within the hospital environment.
- Published
- 1998
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