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6 results on '"M. A. Valentich"'

1. Abstracts from the sixth meeting of the international association of pancreatology, November 2–4, 1994, Chicago, IL

Author

Michael Burdick, Tony Hollingsworth, S. Gansauge, F. Gansauge, K. H. Link, M. H. Schoenberg, B. Poch, H. G. Beger, A. C. C. Wagner, H. Steffen, B. Göke, H. Y. Gaisano, L. Sheu, J. K. Foskett, W. S. Trimble, Y. L. Lee, H. Y. Kwon, H. S. Park, S. M. Lee, H. J. Park, S. aguchi, G. M. Green, K. Mitamura, Y. Komatsu, I. Arai, H. Yamaura, OJ Wang, TE Adrian, S. Teyssen, W. Niebel, E. Niebergall, M. V. Singer, K Umehara, T Ohara, K Kataoka, H Okamura, M Kato, J Sakagami, A Ohta, M Murase, M Hosoda, Y Yamane, K Kashima, Y Ibata, Emil J. Balthazar, P. A. Banks, S. G. Garzof, R. E. Langevin, S. G. Silverman, G. T. Sica, C. Bassi, A. Benini, A. Muner, M. Falconi, H. Abbas, P. Pederzoli, R. Salvia, E. Bertazzoni Minelli, S. Shanmuga Shaskar, M. G. Shearer, C. W. Imrie, G. J. Brodmerkel, P. A. Reed, DL Carr-Locke, A Musa, DR Lichtenstein, J Van Dam, PA Banks, S. Eisele, M. Böchjer, Th. Foitzik, C. Fern’andez-del Castillo, D. W. Rattner, M. J. Ferraro, A. L. Warshaw, J. Schmidt, H. Hotz, H. J. Buhr, E. Klar, A. Heinisch, R. Kadow, U. Bioss, J. Schölmerich, H. Zimgibl, H. -G. Leser, G. Manes, P. G. Rabitti, M. Laccetti, A. Cavallera, L. Paceili, G. Gagiione, G. Uomo, A. Marinqhini, A. R. Zinsmeister, L. J. Melton, E. P. DiMagno, F. Marotta, D. H. Chui, G. Barbi, G. G. Zhong, H. Tajiri, O. Bellini, C McKay, J. N. Baxter, K. Mithöfer, C. Fern’andez-delCastillo, T. W. Frick, K. Lewandrowski, R. Pezzilli, P. Billi, R. Miniero, L. Gullo, B. Barakat, M. Migliuli, B. Rau, M. Schad, M. Schoenberg, F. Richter, R. Matthias, M Imoto, T Ashihara, D Schofield, NM Sharer, KM Heywood, HM Waters, JM Braganza, P Scott, D Bilton, D Deardon, S Lee, PM Taylor, RF McCloy, J. Shen, H. Shao, Z. P. Wu, J. J. Jin, N Shiel, O Cassidy, H Sharma, J. M. Braganza, F. Soöckmann, J. Ahrens, U. Leonhardt, J. Otto, U. Ritzel, G. Ramadori, Fuzhou Tian, JZ Hu, DR Huang, XH Wang, HW Lian, BY Zhang, JG Miao, Xu Li, HT Zhou, P. Esposico, F. Perrocti, M. Visconci, M. I. Vaccaro, M. A. Dagrosa, M. I. Mora, D. O. Sordelli, W. Vogt, H. MeOmann, A. Linseis, A. Holstege, M. R. Weiser, S. A. L. Gibbs, H. B. Hechcman, F. D. Moore, H. V. Worthington, L. P. Runt, R. F. HcCloy, I. A. KacLennan, J. M. Braqanza, D Heath, D Alexander, C Wilson, M Larvin, CW Imrie, MJ McMahon, J Ward, PJ Robinson, AG Chalmers, M Apte, J Wilson, G McCaughan, M Korsten, I Norton, R Piroia, D. Bimmler, G. A. Scheele, Dale E. Bockman, Markus Büchler, Hans G. Beger, G. Cavallini, M. P. Brunori, L. Rigo, P. Bovo, M. Filippini, B. Vaona, V. Di Francesco, L. Frulloni, M. Marcori, P. C. Farri, M. T. Laardini, Riaz Chowdhury, Koji Ochi, Takaaki Mizushima, Tetsuya Tsurumi, Hideo Harada, P. Laver, J. J. Hoist, M. v. d. Ohe, H. Goebell, A. Mi Zumoto, M. G. Sarr, R. Moore, C. F. Frey, H. T. Debas, S. J. Mulvihill, S. Onizuka, H. Kuroda, Y. Kuroda, H. Hongo, S. Matsuzaki, M. Ito, L. Sekine, T. Tsunoda, ’A. Pap, V. Hrisztov, E. Marosi, K. Simon, T. Tak’acs, A. Bonora, G. Talamini, R. Saivia, L. Benini, E. Caldiron, S. Vesentini, Isaac Raijman, Paul Kortan, Gregory B. Haber, H Ramesh, CJ Varghese, PM Kay, T Bottiglieri, S Uden, A Gut, I Segal, C Snehalatha, V Mohan, E. Silva, R. Ceneviva, M. A. L. Velludo, E. Silvan, B. Ruebner, J. E. S. Roselino, M. C. Foss, G. Talaraini, M. Falcaoi, L Frmlltai, V. K Fraacesca, M. Maxwi, B. Vaosa, P. Baro, C. Baxu, P. Pedercoli, G. Cavalliai, G. Taiamini, C. Iacano, M. Faicsai, L. Rige, A. Castagnisi, G. Angelini, P. Bom, B. Vaoss, I. Vantini, G. Sen, P. Pederzali, B Štimee, M Bulajič, T Milosavljevi’c, R Krsti’c, M Markovi’c, V Korneti, M Ugljcš’c, IL Abruzzesse, DB Evans, L Larry, T King, I Raijman, L Roubein, M Frazier, C. lacono, E. Faca, G. Falezza, E. Bonora, PP Aurola, G. Serio, N. Nicoli, G. C. Mansueto, M. Zicari, L. Marchiori, G. Mangiante, G. Seno, M. Imarnura, H. Yamauchi, M. Inoue, M. Onda, E. UchlDa, T. Almqtq, Y. Yamanaka, T. Kqbayashi, T. Yokqyama, K. Aida, K. Sasajima, T. Tajiri, K. Egami, K. Yamashita, Z. Naitq, G. Asano, K. B. Lewandrowski, R. E. Kirby, J. F. Southern, C. C. Compton, J Lip, L Strömmer, J Permert, J Larsson, E. V. Loftus, M. C. Adkins, B. Olivares-Pakzad, K. P. Batts, D. H. Stephens, M. B. Farnell, H. G. Sarr, G. B. Thompson, J. A. van Heerden, D. G. Kelly, L. J. Miller, R. K. Pearson, J. E. Clain, B. T. Petersen, Cancer S. Matsumoto, R. Chowdhury, T. Mizushima, K. Ochi, H. Harada, H. Miki, Hnsan Ozkan, Hiromitsu Saisho, Taketo Yarnaguchi, Takeshi Ishihara, Yasuharu Kikuchi, Toshio Tsuyuguchi, Masao Ohto, C. Pasqual, C. Sperti, G. Liesai, M. Guido, S. Pedrazzoli, C. Pasquali, E. Khajeturian, P. Guolo, H. Tadokoro, S. Watanabe, Y. Moriyoshi, K. Yoshida, K. Shiratori, T. Takeuchi, E. Uchida, T. Kobayashi, T. Aimoto, T. Yokoyama, Z. Naito, M. A. Valentich, B. Monis, N. N. Barotto, and P. Herrera

Subjects
medicine.medical_specialty, Endocrinology, Oncology, business.industry, Family medicine, Gastroenterology, medicine, business
Published
1994
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2. Quercetin enhances pretumorous lesions in the NMU model of rat pancreatic carcinogenesis

Author

N N, Barotto, C B, López, A R, Eynard, M E, Fernández Zapico, and M A, Valentich

Subjects
Male, Cocarcinogenesis, Body Weight, Methylnitrosourea, Organ Size, Rats, Pancreatic Neoplasms, Pregnancy, Carcinogens, Animals, Female, Quercetin, Rats, Wistar, Precancerous Conditions
Abstract

The effect of dietary quercetin (Q) was evaluated in rats treated with nitrosomethylurea (NMU). Pancreatic nodules and focal acinar cell hyperplasias were observed in groups treated with NMU (87%) and Q-NMU (100%). Although rats with dysplastic foci (27%) were found in the NMU-treated group, Q-NMU treatment resulted in a significantly higher number of rats with dysplastic foci (73%). Furthermore, carcinomas in situ (12%) and one microcarcinoma (4%) were found in these animals. Mitosis was significantly increased and apoptosis was diminished in focal acinar cell hyperplasias of the Q-NMU group. Our present results support a promoting and progressing effect of quercetin in the NMU model of rat pancreatic carcinogenesis.

Published
1998

3. Multicentric focal acinar cell hyperplasia and hepatocyte-like cell metaplasia are induced by nitrosomethylurea in rat pancreas

Author

Raul Urrutia, M. A. Valentich, M. Rivolta, and B. Monis

Subjects
medicine.medical_specialty, medicine.medical_treatment, Intraperitoneal injection, Biology, Endocrinology, Pregnancy, Metaplasia, Internal medicine, medicine, Acinar cell, Weaning, Animals, Pancreas, Carcinogen, Hyperplasia, Fatty Acids, Essential, Gastroenterology, Methylnitrosourea, Rats, Inbred Strains, medicine.disease, Dietary Fats, Rats, Pancreatic Neoplasms, medicine.anatomical_structure, Oncology, Hepatocyte, Female, medicine.symptom, Precancerous Conditions
Abstract

The present report is a study of the effect of the carcinogen nitrosomethylurea (NMU) on pancreas of rats receiving during lifetime a lipid-poor diet, that is essential fatty acid deficient or control diets. Rats fed a commercial stock chow were mated. At day 10 of pregnancy, dams were divided into three groups, that were respectively supplied with the commercial chow, the essential fatty acid deficient or the sufficient diet. Each litter was separated at random in two groups that received at day one of life one intraperitoneal injection of NMU (50 mg/kg b.w.) or saline. After weaning, they were maintained for life with the diet that was supplied to their mothers. The pancreas of NMU-treated rats presented diffuse proliferative changes, focal acinar cell hyperplasias (FACH), and focal hepatocyte-like metaplasia (FHLCM). FACH were expansive presumably preneoplastic growths, showing abnormal differentiation. The number of NMU-treated rats bearing FACH and FHLCM did not significantly differ in the three nutritional conditions.

Published
1991

4. A Feulgen microspectrophotometric study of the DNA content of essential fatty acid-deficient rat pancreas treated with nitrosomethylurea

Author

R A, Urrutia, C M, Rivolta, M A, Valentich, and B, Monis

Subjects
Fatty Acids, Essential, Pregnancy, Microspectrophotometry, Animals, Female, Methylnitrosourea, Rats, Inbred Strains, DNA, Pancreas, Rats
Abstract

Microspectrophotometric DNA measurements in exocrine pancreas of essential fatty acid-deficient (EFAD) and EFA-sufficient (EFAS) rats which received a single intraperitoneal injection of the carcinogen nitrosomethylurea (NMU) or saline (SAL) was the subject of the present report. The DNA content of acinar pancreatic cells of SAL-injected EFAD and EFAS rats was diploid. NMU-induced pancreatic focal acinar cell hyperplasia (FACH) had one main cell population with a diploid content, whereas in the intervening parenchyma there were diploid and tetraploid cells. The number of tetraploid cells was smaller in EFAD rat pancreas than in EFAS indicating a diet dependent effect. NMU-induced FACH had a diploid distribution pattern indicating that cells are in a G1, quiescent phase, contrasting with AZA-induced similar lesions which showed an abnormal ploidy. It remains to be established whether DNA phenotypic traits of NMU and AZA induced FACH reflect the neoplastic potentials of both types of lesions. The decreased number of tetraploid cells in EFAD rat pancreas is in keeping with data indicating a promoting effect of the EFA linoleic and arachidonic acids on growth rate of certain cell populations in vitro.

Published
1990

6. Ultrastructural and chemical evidences of heterogeneity and hormone dependence of certain glycocalyces

Author

R. A. Rovasio, M. A. Valentich, C. Boldint, I. Parlanti, A. Paschini, D. Lis, A. R. Eynard, and B. Monis

Subjects
Chemistry, Ultrastructure, Biophysics, General Medicine, Hormone dependence
Abstract

We are gathering evidences which indicate ultrastructural variations and chemical heterogeneity of certain glycocalyces as well as hormone dependence of some of them. Thus, in the lumenal glycocalyx of renal collecting tubules of the guinea-pig granular and filamentous structures were seen (1, fig. 1). By isolation, chemical analysis and cellulose acetate electrophoresis in various buffers of tubular membrane material, glycopeptides and glycosaminoglycans were identified (fig. 2).Guinea-pig and rat transitional epithelium of urinary tract showed a filamentous lumenal glycocalyx demonstrable with ruthenium red (fig. 3) but which only in part stained with concanavalin A. Chemical and electrophoretic data indicated that urothelium contains glycoproteins, glycosaminoglycans and glycolipids.The glycocalyx of the fat globule membrane of milk of several species has a granular appearance as shown by cationic dyes and by concanavalin A (2, 3, fig. 4 and 5). Also, several glycoproteins were isolated and identified on polyacrilamide gel electrophoresis (fig. 6). Glycosaminoglycans and certain glycolipids such as sulfatides were chemically identified in this glycocalyx.

Published
1978
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