396 results on '"M. A. Rodrigo,† and"'
Search Results
2. Effects of Glyphosate on the Environment and Human Health
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L. A. García-Villanueva, V. H. Cuapio-Ortega, I. Y. Henández-Paniagua, G. Fernández-Villagómez, J. Rodrigo-Ilarri, M. E. Rodrigo-Clavero, G. L. Andraca-Ayala, G.B. Hernández-Cruz and S. Banda-Santamaría
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glyphosate, pesticide, human health, toxicity ,Environmental effects of industries and plants ,TD194-195 ,Science (General) ,Q1-390 - Abstract
Glyphosate is a herbicide of a wide spectrum that alters the production of amino acids in plants, leading to their death. Due to its properties, it is used to eliminate weeds that interfere with human activity. The intensive use of this herbicide in the past decades has led to its frequent encounter in the environment as it has been detected in water, animals, and food destined for human consumption. Its impact on human health and the rest of living organisms has not been fully explored, given that many authors enter into contradictions with one another, specifically surrounding the role of surfactants in the commercial presentation of herbicides. The use of pesticides can have significant impacts on ecosystems, threatening bio-cultural diversity due to genetic contamination from transgenic crops. The effectiveness of Glyphosate-based herbicides in weed control is diminishing due to weed tolerance. However, the use of herbicides remains prevalent in large-scale crops due to the challenges of organic food production. In addition, the probable conflict of interest by the agrochemical industry does not bring a full picture with respect to the actions that world governments should take. Banning GLP-based herbicides may lead to the use of other pesticides, in which the long-term impacts will require further studies. The motivation for this research is the review of the latest advances of glyphosate in the world, considering the use and prohibitions of this herbicide, its interaction with water and soil, as well as the effects on both the environment and health. The search for information for this paper was carried out in the Mendeley, Elsevier, and Springer databases by filtering by the suitable keywords.
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- 2024
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3. Training in primary care paediatrics: The role of entrustable professional activities
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C. Villaizán Pérez, M. Aparicio Rodrigo, and F. Fehr
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Primary care paediatrics ,Training ,Entrustable professional activities ,Pediatrics ,RJ1-570 - Abstract
Primary care paediatrics is practiced throughout the countries of Europe with different structures of health care systems and identities of care providers. The best way to guarantee that paediatricians are competently trained and provide high quality care to children and adolescents in primary care is a flexible and comprehensive training program based on practice and demonstration of acquired competencies. Entrustable professional activities represent a significant step toward improving the training and assessment of future healthcare professionals. It may constitute a model that unifies the training standards in primary care and community paediatrics.
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- 2024
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4. La era de la ebullición global: desafíos y oportunidades para la resiliencia climática en la región centroamericana
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Rojas M., José Rodrigo
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- 2024
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5. Bacterial sexually transmitted infections among men who have sex with men and transgender women using oral pre-exposure prophylaxis in Latin America (ImPrEP): a secondary analysis of a prospective, open-label, multicentre study
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Lacerda, Marcus Vinicius, Madruga, José Valdez, Farias, Alessandro, Lima, Josué N, Zonta, Ronaldo, Lauria, Lilian, Urbaez-Brito, J. David, d'Albuquerque, Polyana, Palombo, Claudio, Alencastro, Paulo Ricardo, Ito, Raquel Keiko de Luca, Moreira, Júlio, Benedetti, João L., Maria, Fabio V., Luz, Paula M., Freitas, Lucilene, Geraldo, Kim, Derrico, Monica, Nazer, Sandro, Kristic, Tania, Girade, Renato, Lima, Renato, Carvalho, Antônio R., Rocha, Carla, Leite, Pedro, Lessa, Marcio, Santini-Oliveira, Marilia, Bezerra, Daniel R.B., Souza, Cleo de Oliveira, Corrêa, Jacinto, Alves, Marcelo, Souza, Carolina, Portugal, Camilla, Valões, Mônica dos Santos, Mota, Gabriel Lima, Gomes, Joyce Alves, Falcão, Cynthia Ferreira Lima, Riberson, Fernanda Falcão, Melo, Luciano, Oliveira, Talita Andrade, Oliveira Júnior, Agnaldo Moreira, Fonseca, Bruna, Lannoy, Leonor Henriette, Carlos, Ludymilla Anderson Santiago, Cunha, João Paulo, Coracini, Sonia Maria de Alencastro, Rodrigues, Thiago Oliveira, Mettrau, Emília Regina Scharf, Meira, Kelly Vieira, Tavares, Heder, Valeiras, Ana Paula Nunes Viveiros, Rocha, Taiane Miyake Alves de Carvalho, Amorim, Alex, Sabadini, Patrícia, Córdoba, Luiz Gustavo, Gusmão, Caio, Faustino, Erika, Hansen, Julia Soares da Silva, Cunha, Agatha Mirian, Nishimura, Neuza Uchiyama, Santos, Jaime Eduardo Flygare Razo Prereira, Cano, Aline Barnabé, Dias, Willyam Magnum Telles, Tonhon, Magô, Rezende, Tania Regina, Gomes, Alex, Rodrigues, Eloá dos Santos, Carneiro, Maria das Dores Aires, Castilho, Alexandre, Carvalho, Mariana, Bautista-Aredondo, Sergio, Vermandere, Heleen, Diaz, Steven, Diaz-Sosa, Dulce, Guillen-Diaz-Barriga, Centli, Robles, Rebeca, Medina-Mora, Maria Elena, González, Marcela, Icelo, Ivonne Huerta, Davalos, Araczy Martinez, Castro, José Gomez, Valdez, Luis Obed Ocampo, Barajas, Fernanda Ramírez, González, Verónica Ruiz, Guadarrama, Galileo Vargas, Macías, Israel, Sánchez, Jehovani Tena, Noriega, Juan Pablo Osuna, Moheno M., H. Rodrigo, Ramírez, Jorge M. Bernal, Juarez, Víctor Dante Galicia, Vizcaíno, Gerardo, Arjona, Francisco Javier, Osco Tamayo, Cesar Vidal, Salvatierra Flores, Hector Javier, Cabrera Santa Cruz, Yovanna Margot, Moreno Aguayo, Ricardo Martín, Calvo, Gino, Vargas, Silver, Elorreaga, Oliver, Gutierrez, Ximena, Olivos, Fernando, Caviedes, Damaris, Adriazola, Daniella, Juárez, Eduardo, Mariño, Gabriela, Qquellon, Jazmin, Vasquez, Francesca, Jiron, Jean Pierre, Flores, Sonia, Campos, Karen, Torres Silva, Mayara Secco, Torres, Thiago Silva, Coutinho, Carolina, Ismério Moreira, Ronaldo, da Costa Leite, Iuri, Cunha, Marcelo, da Costa Leite, Pedro Henrique Amparo, Cáceres, Carlos F, Vega-Ramírez, Hamid, Konda, Kelika A, Guanira, Juan, Valdez Madruga, José, Wagner Cardoso, Sandra, Benedetti, Marcos, Pimenta, Maria Cristina, Hoagland, Brenda, Grinsztejn, Beatriz, and Gonçalves Veloso, Valdilea
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- 2024
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6. Transport Properties in Multicomponent Systems Containing Cyclodextrins and Nickel Ions
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Sónia I. G. Fangaia, Daniela S. A. Silva, Ana Messias, Pedro M. G. Nicolau, Artur J. M. Valente, M. Melia Rodrigo, and Ana C. F. Ribeiro
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cyclodextrins ,diffusion ,multicomponent systems ,nickel ions ,transport properties ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
In this work, we propose a comprehensive experimental study of the diffusion of nickel ions in combination with different cyclodextrins as carrier molecules for enhanced solubility and facilitated transport. For this, ternary mutual diffusion coefficients measured by Taylor dispersion method are reported for aqueous solutions containing nickel salts and different cyclodextrins (that is, α-CD, β-CD, and γ-CD) at 298.15 K. A combination of Taylor dispersion and other methods, such as UV-vis spectroscopy, will be used to obtain complementary information on these systems. The determination of the physicochemical properties of these salts with CDs in aqueous solution provides information that allows us to understand solute–solvent interactions, and gives a significant contribution to understanding the mechanisms underlying diffusional transport in aqueous solutions, and, consequently, to mitigating the potential toxicity associated with these metal ions. For example, using mutual diffusion data, it is possible to estimate the number of moles of each ion transported per mole of the cyclodextrin driven by its own concentration gradient.
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- 2024
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7. Same-day initiation of oral pre-exposure prophylaxis among gay, bisexual, and other cisgender men who have sex with men and transgender women in Brazil, Mexico, and Peru (ImPrEP): a prospective, single-arm, open-label, multicentre implementation study
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Urbaez-Brito, J. David, d'Albuquerque, Polyana, Palombo, Claudio, Alencastro, Paulo Ricardo, Ito, Raquel Keiko de Luca, Benedetti, João L., Maria, Fabio V., Luz, Paula M., Freitas, Lucilene, Geraldo, Kim, Derrico, Monica, Nazer, Sandro, Kristic, Tania, Girade, Renato, Lima, Renato, Carvalho, Antônio R., Rocha, Carla, Leite, Pedro, Lessa, Marcio, Santini-Oliveira, Marilia, Bezerra, Daniel R.B., Souza, Cleo de Oliveira, Corrêa, Jacinto, Alves, Marcelo, Souza, Carolina, Portugal, Camilla, Valões, Mônica dos Santos, Mota, Gabriel Lima, Gomes, Joyce Alves, Falcão, Cynthia Ferreira Lima, Riberson, Fernanda Falcão, Melo, Luciano, Oliveira, Talita Andrade, Oliveira Júnior, Agnaldo Moreira, Fonseca, Bruna, Lannoy, Leonor Henriette, Carlos, Ludymilla Anderson Santiago, Cunha, João Paulo, Coracini, Sonia Maria de Alencastro, Rodrigues, Thiago Oliveira, Mettrau, Emília Regina Scharf, Meira, Kelly Vieira, Tavares, Heder, Valeiras, Ana Paula Nunes Viveiros, Rocha, Taiane Miyake Alves de Carvalho, Amorim, Alex, Sabadini, Patrícia, Córdoba, Luiz Gustavo, Gusmão, Caio, Faustino, Erika, Hansen, Julia Soares da Silva, Cunha, Agatha Mirian, Nishimura, Neuza Uchiyama, Santos, Jaime Eduardo Flygare Razo Prereira, Cano, Aline Barnabé, Dias, Willyam Magnum Telles, Tonhon, Magô, Rezende, Tania Regina, Gomes, Alex, Rodrigues, Eloá dos Santos, Carneiro, Maria das Dores Aires, Castilho, Alexandre, Carvalho, Mariana, Diaz-Sosa, Dulce, Guillen-Diaz-Barriga, Centli, Hernández, Lorena, Robles, Rebeca, Medina-Mora, Maria Elena, González, Marcela, Icelo, Ivonne Huerta, Davalos, Araczy Martinez, Castro, José Gomez, Valdez, Luis Obed Ocampo, Barajas, Fernanda Ramírez, González, Verónica Ruiz, Guadarrama, Galileo Vargas, Macías, Israel, Sánchez, Jehovani Tena, Noriega, Juan Pablo Osuna, Moheno M, H. Rodrigo, Ramírez, Jorge M. Bernal, Juarez, Víctor Dante Galicia, Vizcaíno, Gerardo, Arjona, Francisco Javier, Calvo, Gino, Vargas, Silver, Elorreaga, Oliver, Gutierrez, Ximena, Olivos, Fernando, Caviedes, Damaris, Adriazola, Daniella, Juárez, Eduardo, Mariño, Gabriela, Qquellon, Jazmin, Vasquez, Francesca, Jiron, Jean Pierre, Flores, Sonia, Campos, Karen, Veloso, Valdiléa G, Cáceres, Carlos F, Hoagland, Brenda, Moreira, Ronaldo I, Vega-Ramírez, Hamid, Konda, Kelika A, Leite, Iuri C, Bautista-Arredondo, Sergio, Vinícius de Lacerda, Marcus, Valdez Madruga, José, Farias, Alessandro, Lima, Josué N, Zonta, Ronaldo, Lauria, Lilian, Tamayo, Cesar Vidal Osco, Flores, Hector Javier Salvatierra, Santa Cruz, Yovanna Margot Cabrera, Aguayo, Ricardo Martín Moreno, Cunha, Marcelo, Moreira, Júlio, Makkeda, Alessandra Ramos, Díaz, Steven, Guanira, Juan V, Vermandere, Heleen, Benedetti, Marcos, Ingold, Heather L, Pimenta, M Cristina, Torres, Thiago S, and Grinsztejn, Beatriz
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- 2023
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8. Oportunidades y desafíos del sector energético en América Central. Algunas refl exiones sobre las centrales hidroeléctricas de Reventazón (Costa Rica) y Barro Blanco (Panamá)
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Rojas M., José Rodrigo, primary and Dembicz, Katarzyna, additional
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- 2023
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9. Bacterial sexually transmitted infections among men who have sex with men and transgender women using oral pre-exposure prophylaxis in Latin America (ImPrEP): a secondary analysis of a prospective, open-label, multicentre study
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Torres Silva, Mayara Secco, Torres, Thiago Silva, Coutinho, Carolina, Ismério Moreira, Ronaldo, da Costa Leite, Iuri, Cunha, Marcelo, da Costa Leite, Pedro Henrique Amparo, Cáceres, Carlos F, Vega-Ramírez, Hamid, Konda, Kelika A, Guanira, Juan, Valdez Madruga, José, Wagner Cardoso, Sandra, Benedetti, Marcos, Pimenta, Maria Cristina, Hoagland, Brenda, Grinsztejn, Beatriz, Gonçalves Veloso, Valdilea, Lacerda, Marcus Vinicius, Madruga, José Valdez, Farias, Alessandro, Lima, Josué N, Zonta, Ronaldo, Lauria, Lilian, Urbaez-Brito, J. David, d'Albuquerque, Polyana, Palombo, Claudio, Alencastro, Paulo Ricardo, Ito, Raquel Keiko de Luca, Moreira, Júlio, Benedetti, João L., Maria, Fabio V., Luz, Paula M., Freitas, Lucilene, Geraldo, Kim, Derrico, Monica, Nazer, Sandro, Kristic, Tania, Girade, Renato, Lima, Renato, Carvalho, Antônio R., Rocha, Carla, Leite, Pedro, Lessa, Marcio, Santini-Oliveira, Marilia, Bezerra, Daniel R.B., Souza, Cleo de Oliveira, Corrêa, Jacinto, Alves, Marcelo, Souza, Carolina, Portugal, Camilla, Valões, Mônica dos Santos, Mota, Gabriel Lima, Gomes, Joyce Alves, Falcão, Cynthia Ferreira Lima, Riberson, Fernanda Falcão, Melo, Luciano, Oliveira, Talita Andrade, Oliveira Júnior, Agnaldo Moreira, Fonseca, Bruna, Lannoy, Leonor Henriette, Carlos, Ludymilla Anderson Santiago, Cunha, João Paulo, Coracini, Sonia Maria de Alencastro, Rodrigues, Thiago Oliveira, Mettrau, Emília Regina Scharf, Meira, Kelly Vieira, Tavares, Heder, Valeiras, Ana Paula Nunes Viveiros, Rocha, Taiane Miyake Alves de Carvalho, Amorim, Alex, Sabadini, Patrícia, Córdoba, Luiz Gustavo, Gusmão, Caio, Faustino, Erika, Hansen, Julia Soares da Silva, Cunha, Agatha Mirian, Nishimura, Neuza Uchiyama, Santos, Jaime Eduardo Flygare Razo Prereira, Cano, Aline Barnabé, Dias, Willyam Magnum Telles, Tonhon, Magô, Rezende, Tania Regina, Gomes, Alex, Rodrigues, Eloá dos Santos, Carneiro, Maria das Dores Aires, Castilho, Alexandre, Carvalho, Mariana, Bautista-Aredondo, Sergio, Vermandere, Heleen, Diaz, Steven, Diaz-Sosa, Dulce, Guillen-Diaz-Barriga, Centli, Robles, Rebeca, Medina-Mora, Maria Elena, González, Marcela, Icelo, Ivonne Huerta, Davalos, Araczy Martinez, Castro, José Gomez, Valdez, Luis Obed Ocampo, Barajas, Fernanda Ramírez, González, Verónica Ruiz, Guadarrama, Galileo Vargas, Macías, Israel, Sánchez, Jehovani Tena, Noriega, Juan Pablo Osuna, Moheno M., H. Rodrigo, Ramírez, Jorge M. Bernal, Juarez, Víctor Dante Galicia, Vizcaíno, Gerardo, Arjona, Francisco Javier, Osco Tamayo, Cesar Vidal, Salvatierra Flores, Hector Javier, Cabrera Santa Cruz, Yovanna Margot, Moreno Aguayo, Ricardo Martín, Calvo, Gino, Vargas, Silver, Elorreaga, Oliver, Gutierrez, Ximena, Olivos, Fernando, Caviedes, Damaris, Adriazola, Daniella, Juárez, Eduardo, Mariño, Gabriela, Qquellon, Jazmin, Vasquez, Francesca, Jiron, Jean Pierre, Flores, Sonia, and Campos, Karen
- Abstract
The global burden of sexually transmitted infections (STIs) poses a challenge in the context of HIV pre-exposure prophylaxis (PrEP) programmes. We aimed to explore factors associated with prevalent, incident, and recurrent STIs in men who have sex with men (MSM) and transgender women on PrEP in Brazil, Mexico, and Peru.
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- 2024
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10. Interactions of Sodium Salicylate with β-Cyclodextrin and an Anionic Resorcin[4]arene: Mutual Diffusion Coefficients and Computational Study
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Diana M. Galindres, Nicolás Espitia-Galindo, Artur J. M. Valente, Sara P. C. Sofio, M. Melia Rodrigo, Ana M. T. D. P. V. Cabral, Miguel A. Esteso, Jhon Zapata-Rivera, Edgar F. Vargas, and Ana C. F. Ribeiro
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β-cyclodextrin ,sodium sulfonated resorcinarenes ,sodium salicylate ,diffusion by Taylor technique ,transport properties ,computational calculations ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
The interaction between sodium salicylate (NaSal) and the two macrocycles 5,11,17,23-tetrakissulfonatomethylene-2,8,14,20-tetra(ethyl)resorcinarene (Na4EtRA) and β-cyclodextrin (β-CD) has been studied by the determination of ternary mutual diffusion coefficients, and spectroscopic and computational techniques. The results obtained by the Job method suggest that the complex formation is given in a 1:1 ratio for all systems. The mutual diffusion coefficients and the computational experiments have shown that the β-CD-NaSal system presents an inclusion process, whereas the Na4EtRA-NaSal system forms an outer-side complex. This fact is also in line with the results obtained from the computational experiments, where the calculated solvation free energy has been found to be more negative for the Na4EtRA-NaSal complex because of the partial entry of the drug inside the Na4EtRA cavity.
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- 2023
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11. Aging predictive factors for oxygenation response and mortality in COVID-19 and acute respiratory distress syndrome (ARDS) patients exposed to prone position: A multicenter cohort study
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Cunha, Marieta Cabral Amaral, primary, C Lunardi, Adriana, additional, Schardong, Jociane, additional, C Righi, Natiele, additional, N Sant’Anna, Guadalupe, additional, P Isensee, Larissa, additional, F Xavier, Rafaela, additional, E Pompeu, Jose, additional, M Weigert, Ranata, additional, L Matte, Darlan, additional, A Cardoso, Rozana, additional, C V Abras, Ana, additional, M V Silva, Antonio, additional, C Dorneles, Camila, additional, W Werle, Roberta, additional, C Starke, Ana, additional, D M Plentz, Rodrigo, additional, C Ferreira, Juliana, additional, and R F Carvalho, Celso, additional
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- 2023
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12. Diffusion of Vanadium Ions in Artificial Saliva and Its Elimination from the Oral Cavity by Pharmacological Compounds Present in Mouthwashes
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Sónia I. G. Fangaia, Ana M. T. D. P. V. Cabral, Pedro M. G. Nicolau, Fernando A. D. R. A. Guerra, M. Melia Rodrigo, Ana C. F. Ribeiro, Artur J. M. Valente, and Miguel A. Esteso
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cyclodextrins ,diffusion ,hyaluronic acid ,ion release ,mouthwashes ,SDS ,Microbiology ,QR1-502 - Abstract
In this study, diffusion coefficients of ammonium vanadate at tracer concentrations in artificial saliva with and without sodium fluoride, at different pH values, were measured using an experimental model based on the Taylor dispersion technique. Ternary mutual diffusion coefficients (D11, D22, D12, and D21) for four aqueous systems {NH4VO3 (component 1) + β-cyclodextrin (β-CD) (component 2),} {NH4VO3 (component 1) + β-cyclodextrin (HP-β-CD) (component 2)}, {NH4VO3 (component 1) + sodium dodecyl sulphate (SDS) (component 2)} and {NH4VO3 (component 1) + sodium hyaluronate (NaHy) (component 2)} at 25.00 °C were also measured by using the same technique. These data showed that diffusion of ammonium vanadate was strongly affected in all aqueous media studied. Furthermore, a significant coupled diffusion of this salt and β-CD was observed through the non-zero values of the cross-diffusion coefficients, D12, allowing us to conclude that there is a strong interaction between these two components. This finding is very promising considering the removal, from the oral cavity, of vanadium resulting from tribocorrosion of Ti-6Al-4V prosthetic devices.
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- 2022
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13. Complexation of 5-Fluorouracil with β-Cyclodextrin and Sodium Dodecyl Sulfate: A Useful Tool for Encapsulating and Removing This Polluting Drug
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Ana M. T. D. P. V. Cabral, Ana C. G. Fernandes, Neuza A. M. Joaquim, Francisco Veiga, Sara P. C. Sofio, Isabel Paiva, Miguel A. Esteso, M. Melia Rodrigo, Artur J. M. Valente, and Ana C. F. Ribeiro
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5-fluorouracil ,β-cyclodextrin ,sodium dodecyl sulphate ,complexation ,diffusion coefficients ,Chemical technology ,TP1-1185 - Abstract
The formation of complexes of the drug 5-fluorouracil (5-FU) with β-cyclodextrin (β-CD) and sodium dodecyl sulphate (SDS) was studied through experimental measurements of the ternary mutual diffusion coefficients (D11, D22, D12, and D21) for the systems {5-FU (component 1) + β-CD (component 2) + water} and {5-FU (component 1) + SDS (component 2) + water} at 298.15 K and at concentrations up to 0.05 mol dm−3 by using the Taylor dispersion method, with the objective of removing this polluting drug from the residual systems in which it was present. The results found showed that a coupled diffusion of 5-FU occurred with both β-CD and SDS, as indicated by the nonzero values of the cross-diffusion coefficients, D12 and D21, as a consequence of the complex formation between 5-FU and the β-CD or SDS species. That is, 5-FU was solubilized (encapsulated) by both carriers, although to a greater extent with SDS (K = 20.0 (±0.5) mol−1 dm3) than with β-CD (K = 10.0 (±0.5) mol−1 dm3). Values of 0.107 and 0.190 were determined for the maximum fraction of 5-FU solubilized with β-CD and SDS (at concentrations above its CMC), respectively. This meant that SDS was more efficient at encapsulating and thus removing the 5-FU drug.
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- 2022
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14. Recomendaciones sobre el uso de la tomografía computarizada en el código ictus: Documento de consenso SENR, SERAU, GEECV-SEN, SERAM
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A. López-Rueda, L. Ibáñez Sanz, M. Alonso de Leciñana, D. de Araújo Martins-Romeo, A. Vicente Bartulos, M. Castellanos Rodrigo, and L. Oleaga Zufiria
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Radiology, Nuclear Medicine and imaging - Published
- 2023
15. Recommendations on the use of computed tomography in the stroke code: Consensus document SENR, SERAU, GEECV-SEN, SERAM
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A. López-Rueda, L. Ibáñez Sanz, M. Alonso de Leciñana, D. de Araújo Martins-Romeo, A. Vicente Bartulos, M. Castellanos Rodrigo, and L. Oleaga Zufiria
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General Earth and Planetary Sciences ,General Environmental Science - Published
- 2023
16. Intraoperative OCT assessment of retinal vascular complications secondary to intraarterial chemotherapy for retinoblastoma
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J. Santamaría Álvarez, J. Català-Mora, M. Barraso Rodrigo, J. Diaz Cascajosa, T. Sola, G. Luis Chantada, J. Mora Graupera, J.P. Muñoz Pérez, and D. Molies Navarrete
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Ophthalmology - Published
- 2023
17. Effect of technology on aging perception.
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M. A. Rodrigo Juárez, Víctor M. González 0001, and Jesús Favela
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- 2018
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18. Association between heart rhythm and cortical sound processing
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Renata S. Marcomini, Ana Claúdia F. Frizzo, Viviane B. de Góes, Simone F. Regaçone, David M. Garner, Rodrigo D. Raimundo, Fernando R. Oliveira, Vitor E. Valenti
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autonomic nervous system ,cardiovascular physiology ,heart rate variability ,neurophysiology ,sound ,speech ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Processing of sound signals is an important factor for conscious human communication and such sound signals may be assessed through cortical auditory evoked potentials. Heart rate variability provides information about heart rate autonomic regulation. The association between resting heart rate variability and cortical auditory evoked potentials was investigated. Resting heart rate variability in the time and frequency domain and the cortical auditory evoked potential components were investigated. Subjects remained at rest for 10 minutes for recording of heart rate variability. Cortical auditory evoked potential examinations were then undertaken through frequency and duration protocols in both ears. Linear regression indicated that the amplitude of the N2 wave of the cortical auditory evoked potentials in the left ear (not right ear) was significantly influenced by the standard deviation of normal-to-normal heart beats (17.7%) and percentage of adjacent heart beat intervals with a difference of duration greater than 50 milliseconds (25.3%) for the time domain heart rate variability indices in the frequency protocol. In the duration protocol and in the left ear the latency of the P2 wave was significantly influenced by low (20.8%) and high frequency bands in normalized units (21%) and low frequency/high frequency ratio (22.4%) indices of heart rate variability spectral analysis. The latency of the N2 wave was significantly influenced bylow frequency (25.8%), high frequency (25.9%) and low frequency/high frequency ratio (28.8%). In conclusion, it is proposed that resting heart rhythm is associated with thalamo-cortical, cortical-cortical and auditory cortex pathways involved with auditory processing in the right hemisphere.
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- 2018
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19. Effect of Cobalt and Chromium Ions on the Chlorhexidine Digluconate as Seen by Intermolecular Diffusion
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Sónia I. G. Fangaia, Pedro M. G. Nicolau, Fernando A. D. R. A. Guerra, M. Melia Rodrigo, Gianluca Utzeri, Ana M. T. D. P. V. Cabral, Artur J. M. Valente, Miguel A. Esteso, and Ana C. F. Ribeiro
- Subjects
artificial saliva ,cobalt chloride ,chromium chloride ,diffusion coefficients ,chlorhexidine digluconate ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Metal ions such as cobalt (II) and chromium (III) might be present in the oral cavity, as a consequence of the corrosion of Co-Cr dental alloys. The diffusion of such metal ions into the organism, carried by saliva, can cause health problems as a consequence of their toxicity, enhanced by a cumulative effect in the body. The effect of the chlorhexidine digluconate, which is commonly used in mouthwash formulations, on the transport of these salts is evaluated in this paper by using the Taylor dispersion technique, which will allow an assessment of how the presence of chlorhexidine digluconate (either in aqueous solution or in a commercial formulation) may affect the diffusion of metal ions. The ternary mutual diffusion coefficients of metal ions (Co and Cr) in the presence of chlorhexidine digluconate, in an artificial saliva media, were measured. Significant coupled diffusion of CoCl2 (and CrCl3) and chlorhexidine digluconate is observed by analysis of the non-zero values of the cross-diffusion coefficients, D12 and D21. The observed interactions between metal ions and chlorhexidine digluconate suggest that the latter might be considered as an advantageous therapeutic agent, once they contribute to the reduction of the concentration of those ions inside the mouth.
- Published
- 2021
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20. Evaluation of Poly(N-Ethyl Pyrrolidine Methacrylamide) (EPA) and Derivatives as Polymeric Vehicles for miRNA Delivery to Neural Cells
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Soto, Altea, primary, Nieto-Díaz, Manuel, additional, Martínez-Campos, Enrique, additional, Noalles-Dols, Ana, additional, Barreda-Manso, María Asunción, additional, Reviriego, Felipe, additional, Reinecke, Helmut, additional, Reigada, David, additional, Muñoz-Galdeano, Teresa, additional, Novillo, Irene, additional, Gallardo, Alberto, additional, Rodríguez-Hernández, Juan, additional, Eritja, Ramón, additional, Aviñó, Anna, additional, Elvira, Carlos, additional, and M. Maza, Rodrigo, additional
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- 2023
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21. HIGH-FAT DIET IN THE PERI-PUBERTAL PERIOD PROGRAMS CARDIOVASCULAR DYSFUNCTION IN ADULT MALE WISTAR RATS
- Author
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Vanusa Guedes Ribeiro, Maiara, primary, Rebeka F. Oliveira, Anna, additional, Natália C. Peres, Maria, additional, Piovan, Silvano, additional, A. Ferreira, Lucas, additional, M. Gomes, Rodrigo, additional, Cezar F. Mathias, Paulo, additional, and Gemima Palma Rigo Wutzow, Kesia, additional
- Published
- 2023
- Full Text
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22. EARLY GLYCOTOXIN EXPOSURE INDUCES EX-VIVO LEFT VENTRICULAR DYSFUNCTION IN ADULT RATS
- Author
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P. C. Mota, Ariel, primary, E. R. Silva, Maria, additional, S. Rosa, Isadora, additional, A. B. L. Sobrinho, Jose, additional, D. Ferreira- Junior, Marcos, additional, V. N. Cavalcante, Keilah, additional, M. Costa, Jaqueline, additional, H. Castro, Carlos, additional, Matafome, Paulo, additional, and M. Gomes, Rodrigo, additional
- Published
- 2023
- Full Text
- View/download PDF
23. Transport Properties of Carbohydrates: Towards the Minimization Toxicological Risks of Cobalt and Chromium Ions
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Esteso, Ana C. V. Trindade, Sónia I. G. Fangaia, Pedro M. G. Nicolau, Ana Messias, Ana C. F. Ribeiro, Daniela S. A. Silva, Artur J. M. Valente, M. Melia Rodrigo, and Miguel A.
- Subjects
cobalt ,chromium ,Co-Cr alloys ,cyclodextrins ,hyaluronic acid ,diffusion coefficient ,Taylor dispersion ,transport properties - Abstract
The influence of oligosaccharides (α-cyclodextrin, β-cyclodextrin and γ-cyclodextrin), and a polysaccharide, sodium hyaluronate (NaHy), on the diffusion of aqueous solutions of cobalt and chromium chlorides has been investigated. Cobalt and chromium are constituents of metal alloys for biomedical use, including dental prostheses. Thus, the release of these ions in the human body can lead to harmful biological effects. The interaction of metal ions with saccharides might have information on the role of mouthwashes in preventing these effects. This interaction has been assessed by measuring multicomponent intermolecular diffusion coefficients at 298.15 K. It has been found that β-cyclodextrin has the highest interaction towards cobalt and chromium ions. This work will contribute to unveiling the mechanisms responsible for transport by diffusion in aqueous solutions, and, therefore, mitigating the potential toxicity inherent to those metal ions.
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- 2023
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24. OC-072 COMPARATIVE STUDY OF THE TROCAR SITE INCISIONAL HERNIA INCIDENCE ACCORDING TO SLOW VS RAPID ABSORPTION SUTURES
- Author
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J Ferreres Serafini, C Olona Casas, E Julià Verdaguer, J Vadillo Bargalló, A Varona Mancilla, M Rodrigo Rodrigo, Á Diaz Martín, and R Jorba Martín
- Subjects
Surgery - Abstract
Aim Abdominal wall closure guidelines recommend the utilization of slow absorption sutures. However, fast absorption sutures are still used for laparoscopic trocar site closure, mainly due to ease of handling and availability. We planned a retrospective cohort study, analysing the incidence of trocar site hernia (TSH) depending on the suture used for the fascial closure. Materials & Methods A retrospective cohort study is carried out including a sample of 200 patients operated in our centre by any elective laparoscopic procedure, by Hasson access technique at the umbilical trocar site. Patients were distributed in 2 groups, according to the suture used: Group-1 Polyglactin, Group-2 Polydioxanone. In both groups the needle that was employed had a J-shape. Patients that had open or robotic surgery, reinterventions, and previous diagnosis of umbilical hernia were excluded. Results 100 patients were included in Group-1, and 100 patients in Group-2. The average age was 57.34 and 63.39 years respectively. The incidence of TSH in Group-1 was 20% with an average follow up of 22.3 months, compared to an 15% TSH incidence in Group-2, with an average follow-up of 20.3 months. These differences were not statistically significant. 80% of TSH were diagnosed in the first 24 months after the surgery. Conclusions Likewise the existing evidence in open surgery wall closure, the use of slow absorption sutures in trocar site closure probably reduces the TSH incidence, without repercussion in comorbidity, however, in our study, the sample was not enough to prove statistical significance. These results should be contrasted with further randomized Control Trials.
- Published
- 2023
25. Do Technology-Related Stimuli Affect Age Estimation?
- Author
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M. A. Rodrigo Juárez, Jesús Favela, and Víctor M. González 0001
- Published
- 2015
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26. Do Technology-Related Stimuli Affect Age Estimation?
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Juarez, M. A. Rodrigo, Favela, Jesús, González, Víctor M., Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Cleland, Ian, editor, Guerrero, Luis, editor, and Bravo, José, editor
- Published
- 2015
- Full Text
- View/download PDF
27. Vericiguat in heart failure: From scientific evidence to clinical practice
- Author
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J R, González-Juanatey, M, Anguita-Sánchez, A, Bayes-Genís, J, Comín-Colet, A, García-Quintana, A, Recio-Mayoral, J L, Zamorano-Gómez, J M, Cepeda-Rodrigo, and L, Manzano
- Subjects
Heart Failure ,Insuficiencia cardíaca ,Stroke Volume ,Heart failure ,Nitric oxide ,General Medicine ,Nitric Oxide ,Heterocyclic Compounds, 2-Ring ,cGMP ,GMPc ,Ventricular Dysfunction, Left ,Pyrimidines ,Vericiguat ,Humans ,Óxido nítrico - Abstract
Despite currently available treatments, risk of death and hospitalizations in patients with heart failure with reduced ejection fraction (HFrEF) remains high. The pathophysiology of HFrEF includes neurohormonal activation characterized by stimulation of deleterious pathways (i.e., sympathetic nervous and renin-angiotensin-aldosterone systems) and suppression of pro-tective pathways such as nitric oxide-dependent pathways. Inhibition or stimulation of some, but not all, of these pathways is insufficient. In HFrEF, there is reduced nitric oxide, soluble guanylate cyclase, and cGMP activity, leading to deleterious effects in the myocardial, vascu-lar, and renal systems. Vericiguat is able to stimulate the activity of this protective pathway. The VICTORIA study demonstrated that the addition of vericiguat to optimal medical treatment in patients with HFrEF and recent decompensation significantly reduced the incidence of the primary endpoint, a composite of cardiovascular death or HF hospitalization, with a number needed to treat of 24 patients and excellent tolerability. (c) 2022 The Authors. Published by Elsevier Espana, S.L.U. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Published
- 2022
28. Same-day initiation of oral pre-exposure prophylaxis among gay, bisexual, and other cisgender men who have sex with men and transgender women in Brazil, Mexico, and Peru (ImPrEP): a prospective, single-arm, open-label, multicentre implementation study
- Author
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Veloso, Valdiléa G, primary, Cáceres, Carlos F, additional, Hoagland, Brenda, additional, Moreira, Ronaldo I, additional, Vega-Ramírez, Hamid, additional, Konda, Kelika A, additional, Leite, Iuri C, additional, Bautista-Arredondo, Sergio, additional, Vinícius de Lacerda, Marcus, additional, Valdez Madruga, José, additional, Farias, Alessandro, additional, Lima, Josué N, additional, Zonta, Ronaldo, additional, Lauria, Lilian, additional, Tamayo, Cesar Vidal Osco, additional, Flores, Hector Javier Salvatierra, additional, Santa Cruz, Yovanna Margot Cabrera, additional, Aguayo, Ricardo Martín Moreno, additional, Cunha, Marcelo, additional, Moreira, Júlio, additional, Makkeda, Alessandra Ramos, additional, Díaz, Steven, additional, Guanira, Juan V, additional, Vermandere, Heleen, additional, Benedetti, Marcos, additional, Ingold, Heather L, additional, Pimenta, M Cristina, additional, Torres, Thiago S, additional, Grinsztejn, Beatriz, additional, Urbaez-Brito, J. David, additional, d'Albuquerque, Polyana, additional, Palombo, Claudio, additional, Alencastro, Paulo Ricardo, additional, Ito, Raquel Keiko de Luca, additional, Benedetti, João L., additional, Maria, Fabio V., additional, Luz, Paula M., additional, Freitas, Lucilene, additional, Geraldo, Kim, additional, Derrico, Monica, additional, Nazer, Sandro, additional, Kristic, Tania, additional, Girade, Renato, additional, Lima, Renato, additional, Carvalho, Antônio R., additional, Rocha, Carla, additional, Leite, Pedro, additional, Lessa, Marcio, additional, Santini-Oliveira, Marilia, additional, Bezerra, Daniel R.B., additional, Souza, Cleo de Oliveira, additional, Corrêa, Jacinto, additional, Alves, Marcelo, additional, Souza, Carolina, additional, Portugal, Camilla, additional, Valões, Mônica dos Santos, additional, Mota, Gabriel Lima, additional, Gomes, Joyce Alves, additional, Falcão, Cynthia Ferreira Lima, additional, Riberson, Fernanda Falcão, additional, Melo, Luciano, additional, Oliveira, Talita Andrade, additional, Oliveira Júnior, Agnaldo Moreira, additional, Fonseca, Bruna, additional, Lannoy, Leonor Henriette, additional, Carlos, Ludymilla Anderson Santiago, additional, Cunha, João Paulo, additional, Coracini, Sonia Maria de Alencastro, additional, Rodrigues, Thiago Oliveira, additional, Mettrau, Emília Regina Scharf, additional, Meira, Kelly Vieira, additional, Tavares, Heder, additional, Valeiras, Ana Paula Nunes Viveiros, additional, Rocha, Taiane Miyake Alves de Carvalho, additional, Amorim, Alex, additional, Sabadini, Patrícia, additional, Córdoba, Luiz Gustavo, additional, Gusmão, Caio, additional, Faustino, Erika, additional, Hansen, Julia Soares da Silva, additional, Cunha, Agatha Mirian, additional, Nishimura, Neuza Uchiyama, additional, Santos, Jaime Eduardo Flygare Razo Prereira, additional, Cano, Aline Barnabé, additional, Dias, Willyam Magnum Telles, additional, Tonhon, Magô, additional, Rezende, Tania Regina, additional, Gomes, Alex, additional, Rodrigues, Eloá dos Santos, additional, Carneiro, Maria das Dores Aires, additional, Castilho, Alexandre, additional, Carvalho, Mariana, additional, Diaz-Sosa, Dulce, additional, Guillen-Diaz-Barriga, Centli, additional, Hernández, Lorena, additional, Robles, Rebeca, additional, Medina-Mora, Maria Elena, additional, González, Marcela, additional, Icelo, Ivonne Huerta, additional, Davalos, Araczy Martinez, additional, Castro, José Gomez, additional, Valdez, Luis Obed Ocampo, additional, Barajas, Fernanda Ramírez, additional, González, Verónica Ruiz, additional, Guadarrama, Galileo Vargas, additional, Macías, Israel, additional, Sánchez, Jehovani Tena, additional, Noriega, Juan Pablo Osuna, additional, Moheno M, H. Rodrigo, additional, Ramírez, Jorge M. Bernal, additional, Juarez, Víctor Dante Galicia, additional, Vizcaíno, Gerardo, additional, Arjona, Francisco Javier, additional, Calvo, Gino, additional, Vargas, Silver, additional, Elorreaga, Oliver, additional, Gutierrez, Ximena, additional, Olivos, Fernando, additional, Caviedes, Damaris, additional, Adriazola, Daniella, additional, Juárez, Eduardo, additional, Mariño, Gabriela, additional, Qquellon, Jazmin, additional, Vasquez, Francesca, additional, Jiron, Jean Pierre, additional, Flores, Sonia, additional, and Campos, Karen, additional
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- 2023
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29. Evaluation of Poly(N-Ethyl Pyrrolidine Methacrylamide) (EPA) and Derivatives as Polymeric Vehicles for miRNA Delivery to Neural Cells
- Author
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Soto, Altea, Nieto-Díaz, Manuel, Martínez-Campos, Enrique, Noalles-Dols, Ana, Barreda-Manso, María Asunción, Reviriego, Felipe, Reinecke, Helmut, Reigada, David, Muñoz-Galdeano, Teresa, Novillo, Irene, Gallardo, Alberto, Rodríguez-Hernández, Juan, Eritja, Ramón, Aviñó, Anna, Elvira, Carlos, M. Maza, Rodrigo, Soto, Altea, Nieto-Díaz, Manuel, Martínez-Campos, Enrique, Noalles-Dols, Ana, Barreda-Manso, María Asunción, Reviriego, Felipe, Reinecke, Helmut, Reigada, David, Muñoz-Galdeano, Teresa, Novillo, Irene, Gallardo, Alberto, Rodríguez-Hernández, Juan, Eritja, Ramón, Aviñó, Anna, Elvira, Carlos, and M. Maza, Rodrigo
- Abstract
MicroRNAs (miRNAs) are endogenous, short RNA oligonucleotides that regulate the expression of hundreds of proteins to control cells’ function in physiological and pathological conditions. miRNA therapeutics are highly specific, reducing the toxicity associated with off-target effects, and require low doses to achieve therapeutic effects. Despite their potential, applying miRNA-based therapies is limited by difficulties in delivery due to their poor stability, fast clearance, poor efficiency, and off-target effects. To overcome these challenges, polymeric vehicles have attracted a lot of attention due to their ease of production with low costs, large payload, safety profiles, and minimal induction of the immune response. Poly(N-ethyl pyrrolidine methacrylamide) (EPA) copolymers have shown optimal DNA transfection efficiencies in fibroblasts. The present study aims to evaluate the potential of EPA polymers as miRNA carriers for neural cell lines and primary neuron cultures when they are copolymerized with different compounds. To achieve this aim, we synthesized and characterized different copolymers and evaluated their miRNA condensation ability, size, charge, cytotoxicity, cell binding and internalization ability, and endosomal escape capacity. Finally, we evaluated their miRNA transfection capability and efficacy in Neuro-2a cells and rat primary hippocampal neurons. The results indicate that EPA and its copolymers, incorporating β-cyclodextrins with or without polyethylene glycol acrylate derivatives, can be promising vehicles for miRNA administration to neural cells when all experiments on Neuro-2a cells and primary hippocampal neurons are considered together.
- Published
- 2023
30. Functional Evaluation of the Visual Pathway in Patients with Multiple Sclerosis Using a Multifunction Stimulator Monitor
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M. Satue, L. Jarauta, J. Obis, M. Cipres, M. J. Rodrigo, C. Almarcegui, I. Dolz, J. R. Ara, J. Martin, L. E. Pablo, and E. Garcia-Martin
- Subjects
Ophthalmology ,RE1-994 - Abstract
Objectives. To assess the capability of the vision monitor unit Monpack One of detecting visual function alterations in patients with multiple sclerosis (MS) and to evaluate the correlation between structural retinal parameters and functional measurements obtained with this device. Methods. Forty-eight patients with MS and 46 healthy controls were included in a cross-sectional study. All participants underwent a complete functional evaluation of the visual pathway, which included low-contrast visual acuity (LCVA), contrast sensitivity vision (CSV), automated perimetry, multifocal visual evoked potentials (mfVEPs), and pattern electroretinogram (ERG). All tests were performed using the vision monitor unit Monpack One (Metrovision, France), a multifunction stimulator device. Retinal structural measurements were obtained in all subjects using Triton swept source optical coherence tomography (Topcon, Japan). Results. Patients with MS presented reduced low-contrast VA (p
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- 2019
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31. 4CPS-245 Prevention of refeeding syndrome in patients on parenteral nutrition: a review of appropriateness
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M Iglesias Rodrigo, C Sebastián Carrasco, C Sangrador Pelluz, N Meca Casasnovas, F Salazar González, B Tenas Rius, and J Nicolás Picó
- Published
- 2023
32. Effect of Hofmeister Ions on Transport Properties of Aqueous Solutions of Sodium Hyaluronate
- Author
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Lenka Musilová, Aleš Mráček, Věra Kašpárková, Antonín Minařík, Artur J. M. Valente, Eduarda F. G. Azevedo, Luis M. P. Veríssimo, M. Melia Rodrigo, Miguel A. Esteso, and Ana C. F. Ribeiro
- Subjects
sodium hyaluronate ,transport properties ,viscosity ,Hofmeister series ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Tracer diffusion coefficients obtained from the Taylor dispersion technique at 25.0 °C were measured to study the influence of sodium, ammonium and magnesium salts at 0.01 and 0.1 mol dm−3 on the transport behavior of sodium hyaluronate (NaHy, 0.1%). The selection of these salts was based on their position in Hofmeister series, which describe the specific influence of different ions (cations and anions) on some physicochemical properties of a system that can be interpreted as a salting-in or salting-out effect. In our case, in general, an increase in the ionic strength (i.e., concentrations at 0.01 mol dm−3) led to a significant decrease in the limiting diffusion coefficient of the NaHy 0.1%, indicating, in those circumstances, the presence of salting-in effects. However, the opposite effect (salting-out) was verified with the increase in concentration of some salts, mainly for NH4SCN at 0.1 mol dm−3. In this particular salt, the cation is weakly hydrated and, consequently, its presence does not favor interactions between NaHy and water molecules, promoting, in those circumstances, less resistance to the movement of NaHy and thus to the increase of its diffusion (19%). These data, complemented by viscosity measurements, permit us to have a better understanding about the effect of these salts on the transport behaviour of NaHy.
- Published
- 2021
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33. Transcranial direct current stimulation (tDCS) improves handgrip performance in Brazilian Jiu-jitsu elite male athletes.
- Author
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DE M. PEDREIRO, RODRIGO C., BRIZZI, ANA CAROLINA B., and PINTO NETO, OSMAR
- Subjects
TRANSCRANIAL direct current stimulation ,ELITE athletes ,MALE athletes ,RESISTANCE training ,MUSCLE strength ,RATE of perceived exertion - Abstract
Copyright of Ido Movement for Culture. Journal of Martial Arts Anthropology is the property of Idokan Poland Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2023
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34. PLATO focal plane assembly (FPA) qualification model (QM): an innovative real-time metrology
- Author
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Juan F. Cabrero Gomez, Ángel Valverde Guijarro, Gonzalo Ramos Zapata, M. Teresa Rodrigo Rodríguez, Luis Gómez Zazo, Luis M. González Fernández, J. Miguel Mas-Hesse, Ana Balado, Miriam Pajas Sanz, Paloma I. Gallego Sempere, Maria Ángeles Alcacera Gil, Irene Catalan Fernandez, David Escribano, Ignacio Muñoz Rebate, and Santiago Martin Iglesias
- Published
- 2022
35. In situ preparation of PNIPAM biphasic hydrogels
- Author
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Sara Izquierdo, M. Melia Rodrigo, Camino Gonzalez-Arellano, Juan M. Benito, José Manuel García Fernández, Francisco Mendicuti, and Gema Marcelo
- Subjects
Polymers and Plastics ,Organic Chemistry ,Materials Chemistry ,General Physics and Astronomy - Published
- 2023
36. Morphological and physiological responses of acai seedlings subjected to different watering regimes/Respostas morfologicas e fisiologicas de mudas de acaizeiros submetidas a diferentes regimes hidricos
- Author
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Silvestre, Walter V. D., Pinheiro, Hugo A., de M. Souza, Rodrigo O.R., and Palheta, Lenilson F.
- Published
- 2016
- Full Text
- View/download PDF
37. Los micromamíferos (Lagomorpha, Eulipotyphla y Rodentia) del yacimiento del Pleistoceno Medio de Cuesta de la Bajada (Teruel, España): Estudio sistemático y consideraciones paleoambientales
- Author
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C. Sesé, E. Soto, M. Santonja, A. Pérez-González, and M. Domínguez-Rodrigo
- Subjects
micromamíferos ,lagomorpha ,eulipotyphla ,rodentia ,pleistoceno medio ,yacimiento de cuesta de la bajada ,teruel ,españa ,Geology ,QE1-996.5 - Abstract
La asociación de micromamíferos determinada en este trabajo es la siguiente: Lagomorpha: Oryctolagus cuniculus; Eulipotyphla: Crocidura cf. russula, cf. Sorex sp., Neomys sp., Soricidae indet. y Talpa sp.; y Rodentia: Eliomys quercinus, Apodemus cf. sylvaticus, Cricetulus (Allocricetus) bursae, Arvicola aff. sapidus, Microtus (Iberomys) brecciensis y Microtus (Terricola) duodecimcostatus. Es una asociación característica del Pleistoceno Medio. El estadio evolutivo de Cricetulus (A.) bursae, Arvicola aff. sapidus y Microtus (I.) brecciensis le aproximan a las poblaciones de dichas especies de algunos yacimientos de la Península Ibérica del Pleistoceno Medio avanzado, pero no final, lo que es acorde con las dataciones numéricas obtenidas en el yacimiento (243-337 ka) que le sitúan en el MIS 8 o 9. Los micromamíferos indican la predominancia de los espacios abiertos con abundante vegetación herbácea y arbustiva, en los que podría haber también alguna zona arbolada. El clima que indican es de tipo mediterráneo, similar al actual en la zona o quizás algo más benigno y más húmedo.
- Published
- 2016
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38. Unrealistic Optimism, Compulsive Purchasing and Debt-Stress among Credit Card Users in Sri Lanka
- Author
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G. M. R. Rodrigo and B. S. Galdolage
- Subjects
Finance ,Computer Networks and Communications ,business.industry ,media_common.quotation_subject ,Payment ,Purchasing ,Credit card ,Optimism ,Hardware and Architecture ,Arrears ,Debt ,Business sector ,Default ,Business ,Software ,media_common - Abstract
Credit cards become increasingly popular in Sri Lanka while a total of 78,201 new issues were in 2019 first quarter (Central Bank report). Credit card usage affects the consumption patterns of people, sometimes leading to purchase excessively with impractical confidence (Omar, et al., 2013). According to the central bank report, around total of 118,905 cards are being defaulted where the payment is in arrears for 90days or more in 2019 showing an increment in credit card debts, which may result in stress among card users. In view of the timeliness and relevance of this issue, this study aims to investigate the impact of unrealistic optimism and compulsive purchasing on debt-stress among credit card users in Sri Lanka. This study employs the quantitative approach in collecting data using self-administered questionnaires among 301 credit cardholders in Western Province, Sri Lanka who were chosen based on the non-probabilistic convenience sampling method. This study found a moderate positive impact of both the unrealistic optimism and compulsive purchasing on debt stress. Further, a moderate positive correlation was found between unrealistic optimism and compulsive purchasing too. This research contributes to fill the gap in the extant literature by broadening the understanding on concepts such as unrealistic optimism, compulsive purchasing, and debt stress which is prevalent among credit card users. Further, as managerial implications, this study provides a better understanding on cardholders in Sri Lanka which might be a good reference for banks, card service providers and investors in developing their policies. Further, it will support the business sector to develop the Sri Lankan non-cash payment market while policymakers and tax authorities can understand the causes of high credit card debts.
- Published
- 2021
39. Effect of potassium dihydrogen citrate on the diffusion behaviour of citric acid
- Author
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M. Melia Rodrigo, Ana M.T.D.P.V. Cabral, Pedro M.G. Nicolau, Ana C.F. Ribeiro, A.J.M. Valente, Sónia I.G. Fangaia, and Miguel A. Esteso
- Subjects
General Materials Science ,Physical and Theoretical Chemistry ,Atomic and Molecular Physics, and Optics - Published
- 2023
40. Host-dependent resistance of Group A Streptococcus to sulfamethoxazole mediated by a horizontally-acquired ECF transporter S component
- Author
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M Kalindu Rodrigo, Aarti Saiganesh, Andrew Hayes, Jack Anstey, Jua Iwasaki, Janessa Pickering, Jessica Hillas, Scott Winslow, Tabitha Woodman, Jake Lacey, Mark van der Linden, Philip Giffard, Steven Tong, Keith Stubbs, Jonathan Carapetis, Asha Bowen, Mark Davies, and Timothy Barnett
- Abstract
Described antimicrobial resistance mechanisms enable bacteria to avoid the direct effects of antibiotics and can be monitored by in vitro susceptibility testing and genetic methods. We have identified a new mechanism of sulfamethoxazole resistance that requires a host metabolite for activity. Using a combination of in vitro evolution and metabolic rescue experiments, we identified an energy-coupling factor (ECF) transporter S component gene (thfT) that enables Group A Streptococcus to acquire extracellular tetrahydrofolate and related compounds. ThfT likely modifies the substrate specificity of an ECF transporter to acquire the end products of folate biosynthesis. As ThfT-mediated resistance is undetectable by routine surveillance methods, our study highlights the need to understand antibiotic susceptibility during infection to reduce inappropriate antibiotic use and treatment failures.
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- 2022
41. 3PC-004 Insulin eye drop formulation: effectiveness, safety and patient satisfaction
- Author
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M Iglesias Rodrigo, F Salazar Gonzalez, J Pardo Pastor, N Meca Casasnovas, C Sebastián Carrasco, G Garreta Fontelles, and J Nicolás Picó
- Published
- 2022
42. A confinable female-lethal population suppression system in the malaria vector, Anopheles gambiae
- Author
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Smidler, Andrea L., Pai, James J., Apte, Reema A., Sánchez C., Héctor M., M. Corder, Rodrigo, Jeffrey Gutiérrez, Eileen, Thakre, Neha, Antoshechkin, Igor, Marshall, John M., Akbari, Omar S., Smidler, Andrea L., Pai, James J., Apte, Reema A., Sánchez C., Héctor M., M. Corder, Rodrigo, Jeffrey Gutiérrez, Eileen, Thakre, Neha, Antoshechkin, Igor, Marshall, John M., and Akbari, Omar S.
- Abstract
Malaria is among the world’s deadliest diseases, predominantly affecting sub-Saharan Africa, and killing over half a million people annually. Controlling the principal vector, the mosquito Anopheles gambiae, as well as other anophelines, is among the most effective methods to control disease spread. Here we develop an innovative genetic population suppression system termed Ifegenia (Inherited Female Elimination by Genetically Encoded Nucleases to Interrupt Alleles) in this deadly vector. In this bicomponent CRISPR-based approach, we disrupt a female-essential gene, femaleless (fle), demonstrating complete genetic sexing via heritable daughter gynecide. Moreover, we show that Ifegenia males remain reproductively viable, and can load both fle mutations and CRISPR machinery to induce fle mutations in subsequent generations, resulting in sustained population suppression. Through modeling, we demonstrate that iterative releases of non-biting Ifegenia males can act as an effective, confinable, controllable, and safe population suppression and elimination system.
- Published
- 2022
43. MiR-182-5p regulates Nogo-A expression and promotes neurite outgrowth of hippocampal neurons in vitro
- Author
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Soto, Altea, primary, Nieto-Díaz, Manuel, additional, Reigada, David, additional, Muñoz-Galdeano, Teresa, additional, Barreda-Manso, M. Asunción, additional, and M. Maza, Rodrigo, additional
- Published
- 2022
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44. Contribution of green roofs to urban arthropod biodiversity in a Mediterranean climate: A case study in València, Spain
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Vicent Benedito Durà, Enric Meseguer, Carmen Hernández Crespo, Miguel Martín Monerris, Ignacio Andrés Doménech, and M. Eugenia Rodrigo Santamalia
- Subjects
Environmental Engineering ,Geography, Planning and Development ,Building and Construction ,Civil and Structural Engineering - Published
- 2023
45. Performance of the SolWat system operating in static mode vs. dynamic for wastewater treatment: Power generation and obtaining reclaimed water
- Author
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J, Torres, M, Vivar, M, Fuentes, A M, Palacios, and M J, Rodrigo
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Disinfection ,Environmental Engineering ,Bacteria ,Escherichia coli ,Water ,General Medicine ,Wastewater ,Management, Monitoring, Policy and Law ,Water Microbiology ,Waste Management and Disposal ,Water Purification - Abstract
Two hybrid SolWat systems operating in static (without flow circulation) versus dynamic (with flow circulation) mode were simultaneously compared. This work aims to demonstrate the viability of SolWat in dynamic mode to: a) adapt to the operation of the WWTP with a continuous flow, in which the wastewater flows continuously for treatment, b) treat a larger volume of water in the system and c) increase the cooling of the PV modules thanks to the cooling of the temperature of the water sample to improve the energy efficiency in the system. Real secondary wastewater effluents from wastewater treatment plants were used, using solar energy for water disinfection and photovoltaic energy production, in order to use the SolWat systems and implement it as a tertiary treatment. A total of five experiments were performed during autumn, winter, spring and summer. Solar disinfection of Escherichia coli, Enterococcus faecalis and Clostridium perfringens was assessed, and physicochemical parameters were also analysed. The UV dose received by the SolWat systems was the same, but not for the microorganisms in the water sample. The static SolWat irradiated a particle (microorganism) for 4 h, while the dynamic SolWat irradiated intermittently, so the latter system received a shorter UV exposure time, and therefore a lower UV dose. Results indicated that, although the microorganisms did not obtain the absolute bacterial inactivation during the SODIS treatment in any SolWat system, adequate inactivation levels were achieved to allow the reuse of the water for various uses (Royal Decree 1620/2007, Regulation (EU) 2020/741), although to a lesser extent for SolWat in dynamic mode, which treated twice the volume of water and reached cooler temperatures. C. perfringens proved to be the most resistant bacterium tested. The total photovoltaic energy production in the dynamic mode system was more energy efficient than the static mode, being even more efficient than the single PV reference system during the spring (3.5%) and summer (2.7%) test, due to the compensating effect by the cooling of the water on the photovoltaic module against the losses caused by radiation.
- Published
- 2022
46. Ternary diffusion in aqueous sodium salicylate + sodium dodecyl sulfate solutions
- Author
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M. Melia Rodrigo, Artur J.M. Valente, Miguel A. Esteso, Ana M.T.D.P.V. Cabral, and Ana C.F. Ribeiro
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General Materials Science ,Physical and Theoretical Chemistry ,Atomic and Molecular Physics, and Optics - Published
- 2022
47. Five-year follow-up of patients with chronic C hepatitis and sustained virological response Seguimiento a 5 años de pacientes con hepatitis crónica C y respuesta viral sostenida
- Author
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I. Puig-del-Castillo, M. Miquel-Planas, M. Vergara-Gómez, A. Cebollero-Agustí, M. Gallach-Montero, B. Dalmau-Obrador, M. Gil-Prades, M. Casas-Rodrigo, J. Sánchez-Delgado, R. Tomás-Tutusaus, and A. Gavarró-Puig
- Subjects
Hepatitis crónica C ,Interferón pegilado alfa-2a ,Interferón pegilado alfa-2b ,Ribavirina ,Chronic C hepatitis ,Pegylated interferon alfa-2a ,Pegylated interferon alfa-2b ,Ribavirin ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Objective: to assess persistence of sustained viral response at 5 years of follow-up in patients with chronic viral hepatitis C treated with pegylated interferon and ribavirin. Design: a descriptive study. Patients: from August 2001 to May 2004, all patients treated at our center with pegylated interferon and ribavirin who achieved a sustained viral response were consecutively enrolled (93 patients). Demographic, histological, biochemical, and virological data were collected during treatment and 5 years after achievement of the sustained viral response. Eighty-six percent of patients enrolled (n = 80) attended the control visit at 5 years. Results: mean age of enrolled patients was 41 years (standard deviation = 10 years), and 30.1% (n = 28) were women. Liver biopsy had been performed before treatment in 68.8% of patients (n = 64), showing no or mild fibrosis in 62.3% (F0 and F1) and significant fibrosis and cirrhosis in 37.7% (F ≥ 3). Genotype distribution was: 58.1% genotype 1 (n = 54); 8.6% genotype 2 (n = 8); 24.7% genotype 3 (n = 23); 7.5% genotype 4 (n = 7), and indeterminate in one patient. Only one patient experienced virological recurrence. All other patients had negative HCV RNA levels and, in the absence of other liver diseases, normal ALT levels. Conclusion: in patients treated with pegylated interferon and ribavirin with sustained viral response, long-term recurrence rate was very low.Objetivo: evaluar la persistencia de respuesta viral sostenida a los 5 años de seguimiento en pacientes con hepatitis crónica por virus C tratados con interferón pegilado y ribavirina. Diseño: estudio descriptivo. Pacientes: desde agosto de 2001 hasta mayo de 2004, se incluyeron de forma consecutiva todos los pacientes de nuestro centro tratados con interferón pegilado y ribavirina que alcanzaron respuesta viral sostenida (93 pacientes). Se recogieron datos demográficos, histológicos, bioquímicos y virológicos durante el tratamiento y a los 5 años de haber obtenido la respuesta viral sostenida. Se presentaron a la visita de control a los 5 años un 86% de los pacientes incluidos (n = 80). Resultados: los pacientes incluidos presentaron una edad media de 41 años (desviación estándar = 10 años); mujeres 30,1% (n = 28). En el 68,8% de los pacientes (n=64) se había realizado biopsia hepática previa al tratamiento, que mostraba ausencia de fibrosis o fibrosis leve en un 62,3% (F0 y F1) y fibrosis significativa o cirrosis en un 37,7% (F≥3). La distribución por genotipos fue: 58,1% genotipo 1 (n = 54); 8,6% genotipo 2 (n = 8); 24,7% genotipo 3 (n = 23); 7,5% genotipo 4 (n = 7) e indeterminado en un caso. Sólo uno de los pacientes presentó recurrencia virológica. El resto de pacientes presentaron niveles de ARN-VHC negativo y, en ausencia de otra hepatopatía, niveles de ALT normales. Conclusión: en pacientes tratados con interferón pegilado y ribavirina con respuesta viral sostenida la tasa de recurrencia a largo plazo es muy baja.
- Published
- 2011
48. Dependence of Viscosity and Diffusion on β-Cyclodextrin and Chloroquine Diphosphate Interactions
- Author
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Lenka Musilová, Miguel A. Esteso, M. Melia Rodrigo, Aleš Mráček, Ana C.F. Ribeiro, Artur J.M. Valente, and Eduarda F. G. Azevedo
- Subjects
chemistry.chemical_classification ,Aqueous solution ,Cyclodextrin ,Chemistry ,Process Chemistry and Technology ,Diffusion ,Chemical technology ,Taylor dispersion ,diffusion ,Analytical chemistry ,Bioengineering ,TP1-1185 ,Chloroquine diphosphate ,drugs ,Viscosity ,Diffusion process ,transport properties ,Chemical Engineering (miscellaneous) ,chloroquine diphosphate ,Ternary operation ,QD1-999 ,solutions - Abstract
Mutual diffusion coefficients of chloroquine diphosphate (CDP) in aqueous solutions both without and with β-cyclodextrin (β-CD) were measured at concentrations from (0.0000 to 0.0100) mol dm−3 and 298.15 K, using the Taylor dispersion technique. Ternary mutual diffusion coefficients (Dik) measured by the same technique are reported for aqueous CDP + β-CD solutions at 298.15 K. The presence of β CD led to relevant changes in the diffusion process, as showed by nonzero values of the cross-diffusion coefficients, D12 and D21 . β-CD concentration gradients produced significant co-current coupled flows of CDP. In addition, the effects of β-CD on the transport of CDP are assessed by comparing the binary diffusion coefficient of aqueous CDP solutions with the main diffusion coefficient (D11 ) measured for ternary {CDP(1) + β-CD(2)} solutions. These observations are supported by viscosity analysis. All data allow to have a better interpretation on the effect of cyclodextrin on the transport behavior of CDP. © 2021 by the authors. Licensee MDPI, Basel, Switzerland., Coimbra Chemistry Centre - FundacAo para a Ciencia e a Tecnologia (FCT), Portuguese Agency for Scientific Research [UID/QUI/UI0313/2019]; COMPETE; Ministry of Education, Youth and Sports of the Czech Republic DKRVO [RP/CPS/2020/003]; University of Alcala (Spain), RP/CPS/2020/003; UID/QUI/UI0313/2019; Fundação para a Ciência e a Tecnologia, FCT; Universidad de Alcalá, UAH; Programa Operacional Temático Factores de Competitividade, POFC
- Published
- 2021
- Full Text
- View/download PDF
49. Growth Arrest Specific 1 (Gas1) Gene Overexpression in Liver Reduces the In Vivo Progression of Murine Hepatocellular Carcinoma and Partially Restores Gene Expression Levels.
- Author
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Natalia Sacilotto, Josefa Castillo, Ángela L Riffo-Campos, Juana M Flores, Olivia Hibbitt, Richard Wade-Martins, Carlos López, M Isabel Rodrigo, Luis Franco, and Gerardo López-Rodas
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Medicine ,Science - Abstract
The prognosis of hepatocellular carcinoma patients is usually poor, the size of tumors being a limiting factor for surgical treatments. Present results suggest that the overexpression of Gas1 (growth arrest specific 1) gene reduces the size, proliferating activity and malignancy of liver tumors. Mice developing diethylnitrosamine-induced hepatocellular carcinoma were subjected to hydrodynamic gene delivery to overexpress Gas1 in liver. This treatment significantly (p < 0.05) reduced the number of large tumors, while the difference in the total number of lesions was not significant. Moreover, the number of carcinoma foci in the liver and the number of lung metastases were reduced. These results are related with the finding that overexpression of Gas1 in Hepa 1-6 cells arrests cell cycle before S phase, with a significant (p < 0.01) and concomitant reduction in the expression of cyclin E2 gene. In addition, a triangular analysis of microarray data shows that Gas1 overexpression restores the transcription levels of 150 genes whose expression was affected in the diethylnitrosamine-induced tumors, thirteen of which are involved in the hedgehog signaling pathway. Since the in vivo Gas1 gene delivery to livers of mice carrying hepatocellular carcinoma reduces the size and proliferating activity of tumors, partially restoring the transcriptional profile of the liver, the present study opens promising insights towards a therapeutic approach for hepatocellular carcinoma.
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- 2015
- Full Text
- View/download PDF
50. Diffusion and structural behaviour of the dl-2-aminobutyric acid
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Miguel A. Esteso, Ana C.F. Ribeiro, Luis M.P. Verissimo, M.L. Ramos, M. Melia Rodrigo, Licínia L. G. Justino, Carmen M. Romero, and Hugh D. Burrows
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Activity coefficient ,chemistry.chemical_classification ,Aqueous solution ,Chemistry ,Diffusion ,02 engineering and technology ,Limiting ,010402 general chemistry ,01 natural sciences ,Aminobutyric acid ,Atomic and Molecular Physics, and Optics ,0104 chemical sciences ,Amino acid ,chemistry.chemical_compound ,Monomer ,13c nmr spectroscopy ,020401 chemical engineering ,Computational chemistry ,General Materials Science ,0204 chemical engineering ,Physical and Theoretical Chemistry - Abstract
dl -2-Aminobutyric acid (α-aminobutyric acid or AABA) is a non-protein amino acid with important physiological properties, and with considerable relevance in different areas, such as fundamental research and pharmaceutical industry. In this paper, the binary mutual diffusion coefficients of AABA in non-buffered aqueous solutions (0.001–0.100) mol·dm−3 at 298.15 K were measured. From these diffusion data, limiting values at infinitesimal concentration, D0, as well as those of the thermodynamic factors, FT, and activity coefficients, γ, were estimated. These data for AABA were compared with the data previously obtained for dl -4-aminobutyric acid (GABA). The difference of the behaviour of these transport properties for both amino-acids was explained based on the structural differences for the monomeric zwitterionic species of AABA and GABA. Such structural differences are supported by both 1H and 13C NMR spectroscopy and theoretical calculations, which indicate that the predominant species of AABA in these solutions is the extended zwitterionic form in contrast with the curled one of GABA.
- Published
- 2019
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