Search

Full list of authors: Kawauchi, K.; Murgas, F.; Palle, E.; Narita, N.; Fukui, A.; Hirano, T.; Parviainen, H.; Ishikawa, H. T.; Watanabe, N.; Esparaza-Borges, E.; Kuzuhara, M.; Orell-Miquel, J.; Krishnamurthy, V; Mori, M.; Kagetani, T.; Zou, Y.; Isogai, K.; Livingston, J. H.; Howell, S. B.; Crouzet, N.; de Leon, J. P.; Kimura, T.; Kodama, T.; Korth, J.; Kurita, S.; Laza-Ramos, A.; Luque, R.; Madrigal-Aguado, A.; Miyakawa, K.; Morello, G.; Nishiumi, T.; Rodriguez, G. E. F.; Sanchez-Benavente, M.; Stangret, M.; Teng, H.; Terada, Y.; Gnilka, C. L.; Guerrero, N.; Harakawa, H.; Hodapp, K.; Hori, Y.; Ikoma, M.; Jacobson, S.; Konishi, M.; Kotani, T.; Kudo, T.; Kurokowa, T.; Kusakabe, N.; Nishikawa, J.; Omiya, M.; Serizawa, T.; Tamura, M.; Ueda, A.; Vievard, S.--This is an Open Access article, published by EDP Sciences, under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited., Context. The NASA space telescope TESS is currently in the extended mission of its all-sky search for new transiting planets. Of the thousands of candidates that TESS is expected to deliver, transiting planets orbiting nearby M dwarfs are particularly interesting targets since they provide a great opportunity to characterize their atmospheres by transmission spectroscopy. Aims. We aim to validate and characterize the new sub-Neptune-sized planet candidate TOI-2136.01 orbiting a nearby M dwarf (d = 33.36 ± 0.02pc, Teff = 3373 ± 108 K) with an orbital period of 7.852 days. Methods. We use TESS data, ground-based multicolor photometry, and radial velocity measurements with the InfraRed Doppler (IRD) instrument on the Subaru Telescope to validate the planetary nature of TOI-2136.01, and estimate the stellar and planetary parameters. We also conduct high-resolution transmission spectroscopy to search for helium in its atmosphere. Results. We confirm that TOI-2136.01 (now named TOI-2136b) is a bona fide planet with a planetary radius of Rp = 2.20 ± 0.07R⊕ and a mass of Mp = 4.7−2.6+3.1 M⊕. We also search for helium 10830 Å absorption lines and place an upper limit on the equivalent width of, The MEarth Project acknowledges funding from the David and Lucile Packard Fellowship for Science and Engineering, the National Science Foundation under grants AST-0807690, AST-1109468, AST-1616624 and AST-1004488 (Alan T. Waterman Award), the National Aeronautics and Space Administration under Grant No. 80NSSC18K0476 issued through the XRP Program, and the John Templeton Foundation. Based on observations obtained with the Samuel Oschin 48-inch Telescope at the Palomar Observatory as part of the Zwicky Transient Facility project. Z.T.F. is supported by the National Science Foundation under Grant No. AST-1440341 and a collaboration including Caltech, IPAC, the Weizmann Institute for Science, the Oskar Klein Center at Stockholm University, the University of Maryland, the University of Washington, Deutsches Elektronen-Synchrotron and Humboldt University, Los Alamos National Laboratories, the TANGO Consortium of Taiwan, the University of Wisconsin at Milwaukee, and Lawrence Berkeley National Laboratories. Operations are conducted by COO, IPAC, and UW. Our data reductions benefited from PyRAF and PyFITS that are the products of the Space Telescope Science Institute, which is operated by AURA for NASA. G.M. has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No. 895525. R.L. acknowledges financial support from the Spanish Ministerio de Ciencia e Innovación, through project PID2019-109522GB-C52, and the Centre of Excellence “Severo Ochoa” award to the Instituto de Astrofísica de Andalucía (SEV-2017-0709). J.K. gratefully acknowledge the support of the Swedish National Space Agency (SNSA; DNR 2020-00104). This work is partly supported by JSPS KAKENHI Grant Numbers JP21K20376, JP21K13975, JP21H00035, JP21K20388, JP20K14518, JP20K14521, JP19K14783, JP18H05439, JP17H04574, by Grant-in-Aid for JSPS Fellows Grant Number JP20J21872, by JST CREST Grant Number JPMJCR1761, by Astrobiology Center PROJECT Research AB031014, by Astrobiology Center SATELLITE Research project AB022006, and the Astrobiology Center of National Institutes of Natural Sciences (NINS) (Grant Number AB031010). M.T. is supported by MEXT/JSPS KAKENHI grant Nos. 18H05442, 15H02063, and 22000005. Some of the observations in the paper made use of the High-Resolution Imaging instrument Alopeke obtained under Gemini LLP Proposal Number: GN/S-2021A-LP-105. Alopeke was funded by the NASA Exoplanet Exploration Program and built at the NASA Ames Research Center by Steve B. Howell, Nic Scott, Elliott P. Horch, and Emmett Quigley. Alopeke was mounted on the Gemini North (and/or South) telescope of the international Gemini Observatory, a program of NSF’s OIR Lab, which is managed by the Association of Universities for Research in Astronomy (AURA) under a cooperative agreement with the National Science Foundation, on behalf of the Gemini partnership: the National Science Foundation (United States), National Research Council (Canada), Agencia Nacional de Investigación y Desarrollo (Chile), Mnisterio de Ciencia, Tecnología e Innovación (Argentina), Ministério da Ciência, Tecnologia, Inovações e Comunicações (Brazil), and Korea Astronomy and Space Science Institute (Republic of Korea).

We present new transit observations of the hot Jupiter WASP-74 b ($T_\mathrm{eq} \sim$ 1860 K) using the high-resolution spectrograph HARPS-N and the multi-colour simultaneous imager MuSCAT2. We refine the orbital properties of the planet and its host star, and measure its obliquity for the first time. The measured sky-projected angle between the stellar spin-axis and the planet's orbital axis is compatible with an orbit well-aligned with the equator of the host star ($\lambda = 0.77\pm0.99 \mathrm{deg}$). We are not able to detect any absorption feature of H$\alpha$, or any other atomic spectral features, in its high-resolution transmission spectra due to low S/N at the line cores. Despite previous claims regarding the presence of strong optical absorbers such TiO and VO gases in the atmosphere of WASP-74 b, the new ground-based photometry combined with a reanalysis of previously reported observations from the literature shows a slope in the low-resolution transmission spectrum steeper than expected from Rayleigh scattering alone., Comment: Accepted for publication in Astronomy & Astrophysics. 12 pages, 8 figures, 5 tables

Full list of authors: Fukui, A.; Korth, J.; Livingston, J. H.; Twicken, J. D.; Osorio, M. R. Zapatero; Jenkins, J. M.; Mori, M.; Murgas, F.; Ogihara, M.; Narita, N.; Pallé, E.; Stassun, K. G.; Nowak, G.; Ciardi, D. R.; Alvarez-Hernandez, L.; Béjar, V. J. S.; Casasayas-Barris, N.; Crouzet, N.; de Leon, J. P.; Esparza-Borges, E.; Soto, D. Hidalgo; Isogai, K.; Kawauchi, K.; Klagyivik, P.; Kodama, T.; Kurita, S.; Kusakabe, N.; Luque, R.; Madrigal-Aguado, A.; Rodriguez, P. Montanes; Morello, G.; Nishiumi, T.; Orell-Miquel, J.; Oshagh, M.; Parviainen, H.; Sánchez-Benavente, M.; Stangret, M.; Terada, Y.; Watanabe, N.; Chen, G.; Tamura, M.; Bosch-Cabot, P.; Bowen, M.; Eastridge, K.; Freour, L.; Gonzales, E.; Guerra, P.; Jundiyeh, Y.; Kim, T. K.; Kroer, L. V.; Levine, A. M.; Morgan, E. H.; Reefe, M.; Tronsgaard, R.; Wedderkopp, C. K.; Wittrock, J.; Collins, K. A.; Hesse, K.; Latham, D. W.; Ricker, G. R.; Seager, S.; Vanderspek, R.; Winn, J.; Bachelet, E.; Bowman, M.; McCully, C.; Daily, M.; Harbeck, D.; Volgenau, N. H., We report the discovery of one super-Earth- (TOI-1749b) and two sub-Neptune-sized planets (TOI-1749c and TOI-1749d) transiting an early M dwarf at a distance of 100 pc, which were first identified as planetary candidates using data from the TESS photometric survey. We have followed up this system from the ground by means of multiband transit photometry, adaptive optics imaging, and low-resolution spectroscopy, from which we have validated the planetary nature of the candidates. We find that TOI-1749b, c, and d have orbital periods of 2.39, 4.49, and 9.05 days, and radii of 1.4, 2.1, and 2.5 R ⊕, respectively. We also place 95% confidence upper limits on the masses of 57, 14, and 15 M ⊕ for TOI-1749b, c, and d, respectively, from transit timing variations. The periods, sizes, and tentative masses of these planets are in line with a scenario in which all three planets initially had a hydrogen envelope on top of a rocky core, and only the envelope of the innermost planet has been stripped away by photoevaporation and/or core-powered mass-loss mechanisms. These planets are similar to other planetary trios found around M dwarfs, such as TOI-175b,c,d and TOI-270b,c,d, in the sense that the outer pair has a period ratio within 1% of 2. Such a characteristic orbital configuration, in which an additional planet is located interior to a near 2:1 period-ratio pair, is relatively rare around FGK dwarfs. © 2021. The American Astronomical Society. All rights reserved., Funding for the TESS mission is provided by NASA's Science Mission Directorate. We acknowledge the use of public TESS data from pipelines at the TESS Science Office and at the TESS Science Processing Operations Center (SPOC). Resources supporting this work were provided by the NASA High-End Computing (HEC) Program through the NASA Advanced Supercomputing (NAS) Division at Ames Research Center for the production of the SPOC data products. This research has made use of the Exoplanet Follow-up Observation Program website, which is operated by the California Institute of Technology, under contract with the National Aeronautics and Space Administration under the Exoplanet Exploration Program. This paper includes data collected by the TESS mission that are publicly available from the Mikulski Archive for Space Telescopes (MAST). This paper is based on observations made with the MuSCAT3 instrument, developed by the Astrobiology Center and under financial supports by JSPS KAKENHI (JP18H05439) and JST PRESTO (JPMJPR1775), at Faulkes Telescope North on Maui, HI, operated by the Las Cumbres Observatory. Based on observations obtained with the Samuel Oschin 48 inch Telescope at the Palomar Observatory as part of the Zwicky Transient Facility project. Z.T.F. is supported by the National Science Foundation under grant No. AST-1440341 and a collaboration including Caltech, IPAC, the Weizmann Institute for Science, the Oskar Klein Center at Stockholm University, the University of Maryland, the University of Washington, Deutsches Elektronen-Synchrotron and Humboldt University, Los Alamos National Laboratories, the TANGO Consortium of Taiwan, the University of Wisconsin at Milwaukee, and Lawrence Berkeley National Laboratories. Operations are conducted by COO, IPAC, and UW. This work is partly supported by JSPS KAKENHI grant Nos. JP17H04574, JP18H01265, and JP18H05439, Grant-in-Aid for JSPS Fellows grant No. JP20J21872, JST PRESTO grant No. JPMJPR1775, and a University Research Support Grant from the National Astronomical Observatory of Japan (NAOJ). This work is also partly financed by the Spanish Ministry of Economics and Competitiveness through grants PGC2018-098153-B-C31 and PID2019-109522GB-C53. J.K. gratefully acknowledges the support of the Swedish National Space Agency (DNR 2020-00104). G.M. has received funding from the European Union's Horizon 2020 research and innovation program under the Marie Skodowska-Curie grant agreement No. 895525. M.T. is supported by JSPS KAKENHI grant Nos.18H05442, 15H02063, and 22000005., With funding from the Spanish government through the Severo Ochoa Centre of Excellence accreditation SEV-2017-0709.

Fil: Martinez, Daniel Emilio. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencia Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Geologia de Costas y del Cuaternario. Provincia de Buenos Aires. Gobernacion. Comision de Investigaciones Cientificas. Instituto de Geologia de Costas y del Cuaternario; Argentina

Background:Musculoeskeletal ultrasound (MSUS) is frequently used in several rheumatology units to detect subclinical inflammation in patients with joint symptoms suspected for progression to inflammatory arthritis (IA). Synovitis grade I (EULAR-OMERACT combined score) is known to be a casual finding in healthy individuals, but studies headed to unravel its possible role on rheumatic diseases are sparse.Objectives:To investigate the correlation between synovitis grade I, and the diagnosis of IA made after a year follow-up period since MSUS findings, in patients of an MSUS-specialized unit of a Rheumatology Department.Methods:We conducted a descriptive, retrospective and unicentric study. 30 patients were selected from the MSUS-specialized unit of our Rheumatology Department from July-18 to January-19. Patients presenting synovitis grade 0 (exclusively), 2 and/or 3 on combined score were excluded. Data collection at baseline included age, sex, immunological profile and previous physical examination to the MSUS findings, as well as the diagnosis made by the rheumatologist in 1-year visit follow-up: dividing the patient sample into two groups: those who were diagnosed with IA and those not. Non-parametric statistical tests for comparing means were used.Results:The mean age was 51,6 years and 70% were females. 6 (20%) patients were diagnosed with inflammatory arthritis after a year follow-up: 2 (4,8%) psoriatic arthritis, 1 (3,3%) undifferentiated arthritis, 1 (3,3%) rheumatoid arthritis, 1 (3,3%) Sjögren’s syndrome. Non-inflammatory arthropathies were also found 24 (80%), of which, 12 (40%) were non-specific arthralgias and 8 (19%) osteoarthritis.In the group of patients who did not developed an IA the mean C-reactive protein (CPR) value was 3,12 mg/L and erythrocyte sedimentation rate (ESR) was 8,2 mm; all of them were rheumatoid factor (RF) positive and ACPA-negative except one patient. 5 (31,3%) patients presented low antinuclear antibodies (ANAs) levels. In those who HLA B-27 and Cw6 were tested (4,25%); both were negative except for one that was HLA B-27 positive. The median number of swollen and painful joint count was 0, and the mean of joints with MSUS involvement was 3,5; the mean involved metacarpophalangeal (MCP) joints was 1,83; proximal interphalangeal (PIP) joints was 1,48 and distal interphalangeal (DIP) joints 0,21.Among the group of patients that developed an IA the mean of CPR and ESR was 9,27 mg/L and 14,17 mm respectively; 2 (33%) patients were RF- positive, and 1 ACPA-positive. ANAs were positive in 3 cases (50%). The median of swollen joint count was 2 and for painful joint count was 0, the median of joints with MSUS involvement was 4,5. The mean of MSUS involvement was for MCP, PIP and DIP joints: 1,67, 2 and 0. Comparing the means of CPR values in the two groups with Student’s t-test we obtained a statistically significant difference (p=0,023). No other significant differences were found.Conclusion:Despite the limitations and possible statistical bias, the presence of MSUS-defined synovitis grade I and elevated CRP levels could be related to further diagnoses of inflammatory arthropathy. Besides, the absence of synovitis in DIP joints might have a diagnostic role. Normal physical exploration and normal levels of CRP might suggest low MSUS value. However, further research is needed to clarify the role of MSUS-defined synovitis grade I.References:[1]D’Agostino MA et al. Scoring ultrasound synovitis in rheumatoid arthritis: a EULAR-OMERACT ultrasound taskforce-Part 1: definition and development of a standardized, consensus-based scoring system. RMD Open. 2017;3(1):e000428.[2]Van den Berg R et al. What is the value of musculoskeletal ultrasound in patients presenting with arthralgia to predict inflammatory arthritis development? A systematic literature review. Arthritis Research & Therapy (2018) 20:228.Disclosure of Interests:None declared

The aim of this study was to evaluate the effectiveness of a protocol based on GnRH and PGF

Resumen Antecedentes Los tejidos fijados y embebidos en parafina son una fuente importante de material para diagnostico e investigacion. La amplificacion de ADN desde este tipo de tejidos, mediante reaccion en cadena de la polimerasa (PCR), es afectada por el tipo de fijador y los tiempos de fijacion empleados. Para determinar el parametro que mejor se adecue a las condiciones de trabajo de nuestro laboratorio de Patologia Molecular, evaluamos el efecto de cinco fijadores sobre la calidad del ADN bajo condiciones controladas. Material y Metodo Muestras de mucosa gastrica fueron fijadas, embebidas en parafina y luego procesadas para extraccion de ADN empleando un protocolo basado en digestion con proteinasa K. La calidad del ADN se evaluo mediante amplificacion de tres fragmentos del gen β-globina (268, 536 y 989 pb). Resultados No observamos mayores diferencias entre fijadores ni tiempos de fijacion en la amplificacion de ADN de 268 y 536 pb. No obstante, la amplificacion del fragmento mayor (981 pb) se vio alterada al aumentar el tiempo de fijacion, a excepcion de aquellas muestras fijadas en etanol 70% que presentaron una banda de similar intensidad a la obtenida para muestras control (tejido fresco congelado). Conclusiones Estos resultados nos proporcionan una pauta para el diseno de experimentos de acuerdo a la calidad del material archivado, optimizando recursos humanos e insumos.

Room temperature mechanical properties, such as flexural strength and impact resistance, of epoxies and graphite/epoxy composites go through a maximum as a function of epoxy conversion. For tetraglycidyl 4,4′-diaminodiphenylmethane (TGDDM)-4,4′-diamlnodiphenylsulfone (DDS) formulations, the recommended cure cycle prescribes a maximum temperature close to 177°C. The maximum extent of reaction that may be obtained at this temperature is determined from the vitrification curve. At this maximum conversion, balanced mechanical and physical properties are attained in the partially cured specimen. However, if the standard cycle is used to cure thick parts, the maximum temperature inside the sample increases beyond 177°C. This leads to a complete conversion in most of the part and a consequent impairment of resulting physical and mechanical properties. It is shown how numerical solutions of differential energy and mass balances may be used to propose alternative cure cycles such that the maximum conversion at every point remains bounded by the vitrification curve. An illustration for a particular thickness is provided.

Olivopontocerebellar atrophy (OPCA) is a degenerative disease of the nervous system (NS) which currently has no known cure. The neuronal depopulation it brings about produces a number of neurochemical alterations, including a reduction in levels of gamma-aminobutyric acid (GABA) in tissues and in cerebrospinal fluid (CSF). The drug gabapentin (GBP) has proved to be capable of increasing the concentration of this neurotransmitter in the central nervous system, and of improving the cerebellar ataxia in other diseases with a similar neurochemical substrate.We describe two sporadic cases of OPCA, who were administered GBP. In one of the cases, the ataxia was noticeably reduced after taking one 400 mg dose. In the other case, a considerable improvement was observed in a very intense cerebellar dysarthria, and there was less oscillopsia with better vision, following administration of GBP for a period of over 12 months.GBP has proved to be capable of slowing down the motor disorders reported by patients in the course of OPCA. We discuss how such effects are due to the increased levels of GABA in the NS triggered by the drug. Finally, we suggest that the administration of GBP could constitute an effective symptomatic treatment for the ataxia and the dysarthria caused by OPCA, and that the improvement in symptoms following single doses of GBP could be valuable in cases of OPCA, as well as other types of ataxia, that are ideal for taking advantage of the stimulus of the GABAergic neurotransmission.

To detect risk factors related with eating disorders.Descriptive, cross-sectional study.5 secondary schools in the Virgen de Rocío health area in Seville, Spain.789 students enrolled in the first and second years of compulsory secondary school, and their families. MAIN MEASURES. Body mass index, risk behaviors related with food and exercise, influence of the mass media on models of desirable body types, and family climate. Data were obtained with three validated questionnaires: the Eating Attitudes Test (EAT-40), the CIMEC-26, and the Family Environment Scale (FES).In 6.9% of the participants, BMI was between 15 and 17, reflecting slight malnutrition. On the EAT scale, 68 participants (8.8%) had scores that were indicative of illness or risk of illness, and 25 (3.3%) could be diagnosed as having eating behavior disorder according to DSM-IV criteria. According to the CIMEC questionnaire, 104 participants (13.5%) were found to be significantly vulnerable to media pressures, and 85 (11.1%) were considered highly vulnerable. Parents' comments on eating behavior were related with the results on the EAT-40 CIMEC questionnaires (P=.01). No statistically significant relationship was found between family climate scores and the scores on the EAT-40 or CIMEC questionnaires. Students in rural or suburban area schools scored higher on the EAT-40 (P=.04) and CIMEC (P=.01) than students in urban or city center schools.The identification of persons considered at risk will allow us to use primary prevention programs more efficiently.

We present a case of multiple symmetric lipomatosis Type I (Madelung's disease) with severe organic affection, hepatic cirrhosis, sever sensitive polyneuropathy and neuropathic ulceration at the left lower limb. A nephrotic syndrome developed in a larval form due to proliferative glomerulonephritis as the result of a metainfectious complications of the infection at the lower limb. We discuss the etiopathogenicity of the organic affection and we highlight the pathogenic links between the disease and its complications.

Among the mechanisms suggested to account for degradation of varistor materials, ion migration has strong support. Mobile, positively charged ions in the depletion layer would be the key element in degradation. In this context, the authors discuss the consequences of an electrical stressing on the current-temperature characteristic of a comment varistor.

ResumenEl trasplante de órganos sólidos se ha incorporado al tratamiento de pacientes portadores de una gran variedad de condiciones clínicas. La falta de una adecuada pesquisa de donantes así como su inadecuado manejo médico son factores relevantes para la ocurrencia de la actual gran carencia de órganos sólidos disponibles para ser trasplantados en nuestro País. En este artículo se presenta una revisión acotada de los términos usualmente empleados y luego se refiere primordialmente a los donantes fallecidos en muerte encefálica (DFME). Se hace énfasis en las ultimas cifras nacionales, las formas con las que contamos para poder predecir la capacidad generadora de potenciales donantes, cómo y dónde detectarlos, las principales estrategias para aumentar su detección, los aspectos fisiopatológicos subyacentes a esta particular condición. Finalmente se presentan algunas recomendaciones para el adecuado manejo del donante potencial, desde su detección hasta que se convierte en donante efectivo.SummarySolid organ transplantation has been incorporated as a valid treatment option for patients that suffer several conditions. The failure to identify potential cadaveric donors early and their subsequent inadequate treatment are undoubtedly relevant factors that go some way to explain the actual shortage of organs available to be transplanted in Chile. In this article we present a review and explanation of the terminology associated with organ donation before focusing on the legal criteria required for the clinical diagnosis of brain-stem death. We use data from other countries in order to predict how many donors should be available in our country as well as trying to anticipate their diagnoses and where they are usually located. The discussion then moves on to present the current reality in Chile before reviewing some measures that have been found useful in other countries to increase donation rates. Finally we present some suggestions on how the patient should be managed from the moment they are considered as a potential donor until they complete the donation process.

We present the optical transmission spectrum of the hot Jupiter WASP-104b based on one transit observed by the blue and red channels of the DBSP spectrograph at the Palomar 200-inch telescope and 14 transits observed by the MuSCAT2 four-channel imager at the 1.52 m Telescopio Carlos Sanchez. We also analyse 45 additional K2 transits, after correcting for the flux contamination from a companion star. Together with the transit light curves acquired by DBSP and MuSCAT2, we are able to revise the system parameters and orbital ephemeris, confirming that no transit timing variations exist. Our DBSP and MuSCAT2 combined transmission spectrum reveals an enhanced slope at wavelengths shorter than 630 nm and suggests the presence of a cloud deck at longer wavelengths. While the Bayesian spectral retrieval analyses favour a hazy atmosphere, stellar spot contamination cannot be completely ruled out. Further evidence, from transmission spectroscopy and detailed characterisation of the host star's activity, is required to distinguish the physical origin of the enhanced slope., 17 pages, 14 figures, accepted for publication in MNRAS

The in vitro susceptibility of Mycobacterium fortuitum, Mycobacterium chelonae and Mycobacterium avium to ciprofloxacin, norfloxacin and ofloxacin was studied by the agar dilution method. All strains of Mycobacterium fortuitum were inhibited by 2 mg/ml or less of these antimicrobial agents. Concentrations higher than achievable blood levels were necessary to inhibit Mycobacterium chelonae and Mycobacterium avium.

The in vitro susceptibility of Mycobacterium tuberculosis, Mycobacterium bovis, Mycobacterium africanum, Mycobacterium avium, Mycobacterium fortuitum, and Mycobacterium chelonae (M. chelonei) to ticarcillin in combination with calvulanic acid (CA) was studied by the agar dilution method. All the M. tuberculosis, M. bovis, and M. africanum strains were inhibited at a ticarcillin concentration of 32 micrograms/ml or lower in combination with 5 micrograms of CA. M. chelonae and M. avium strains proved resistant to more than 128 micrograms of ticarcillin plus 5 micrograms of CA per ml. M. fortuitum strains needed 128 micrograms of ticarcillin plus 5 micrograms of CA to inhibit approximately 30% of the isolates.

The in vitro susceptibility of Mycobacterium fortuitum and Mycobacterium chelonei to cefmetazole was studied by the agar dilution method. At a concentration of 16 micrograms/ml or lower, 44 isolates (96%) of M. fortuitum and 8 isolates (40%) of M. chelonei were inhibited.