Search

The report of a detection of an absorption profile centred at 78 MHz in the continuum radio background spectrum by the EDGES experiment and its interpretation as the redshifted 21 cm signal of cosmological origin has become one of the most debated results of observational cosmology in recent times. The cosmological 21 cm has long been proposed to be a powerful probe for observing the early Universe and tracing its evolution over cosmic time. Even though the science case is well established, measurement challenges posed on the technical ground are not fully understood to the level of claiming a successful detection. EDGES’s detection has naturally motivated a number of experimental attempts worldwide to corroborate the findings. In this paper, we present a precision cross-correlation spectrometer HYPEREION purpose-designed for a precision radio background measurement between 50–120 MHz to detect the absorption profile reported by the EDGES experiment. HYPEREION implements a pre-correlation signal processing technique that self-calibrates any spurious additive contamination from within the system and delivers a differential measurement of the sky spectrum and a reference thermal load internal to the system. This ensures an unambiguous “zero-point” of absolute calibration of the purported absorption profile. We present the system design, measurement equations of the ideal system, systematic effects in the real system, and finally, an assessment of the real system output for the detection of the absorption profile at 78 MHz in the continuum radio background spectrum.

We present a targeted search for low-frequency (144--215\,MHz) FRB emission from five repeating FRBs using 23.3\,hr of archival data taken with the Murchison Widefield Array (MWA) Voltage Capture System (VCS) between 2014 September and 2020 May. This is the first time that the MWA VCS has been used to search for FRB signals from known repeaters, which enables much more sensitive FRB searches than previously performed with the standard MWA correlator mode. We performed a standard single pulse search with a temporal and spectral resolution of $400\,μ$s and 10\,kHz, respectively, over a $100\,\text{pc}\,\text{cm}^{-3}$ dispersion measure (DM) range centred at the known DM of each studied repeating FRB. No FRBs exceeding a $6σ$ threshold were detected. The fluence upper limits in the range of 32--1175\,Jy\,ms and 36--488\,Jy\,ms derived from 10 observations of FRB 20190711A and four observations of FRB 20201124A respectively, allow us to constrain the spectral indices of their bursts to $\gtrsim-1$ if these two repeaters were active during the MWA observations. If free-free absorption is responsible for our non-detection, we can constrain the size of the absorbing medium in terms of the electron temperature $T$ to $, Accepted for publication in MNRAS

In Paper I, we presented an overview of the Southern-sky MWA Rapid Two-metre (SMART) survey, including the survey design and search pipeline. While the combination of MWA's large field-of-view and the voltage capture system brings a survey speed of ~450 square degrees per hour, the survey progression relies on the availability of compact configuration of the Phase II array. Over the past few years, by taking advantage of multiple windows of opportunity when the compact configuration was available, we have advanced the survey to 75% completion. To date, about 10% of the data collected thus far have been processed for a first-pass search, where 10 minutes of observation is processed for dispersion measures out to 250 ${\rm pc\,cm^{-3}}$, to realise a shallow survey for long-period pulsars. The ongoing analysis has led to two new pulsar discoveries, as well as an independent discovery and a rediscovery of a previously incorrectly characterised pulsar, all from ~3% of the data for which candidate scrutiny is completed. Here we describe the strategies for further detailed follow-up including improved sky localisation and convergence to timing solution, and illustrate them using example pulsar discoveries. The processing has also led to re-detection of 120 pulsars in the SMART observing band, bringing the total number of pulsars detected to date with the MWA to 180, and these are used to assess the search sensitivity of current processing pipelines. The planned second-pass (deep survey) processing is expected to yield a three-fold increase in sensitivity for long-period pulsars, and a substantial improvement to millisecond pulsars by adopting optimal de-dispersion plans. The SMART survey will complement the highly successful Parkes High Time Resolution Universe survey at 1.2-1.5 GHz, and inform future large survey efforts such as those planned with the low-frequency Square Kilometre Array., 22 pages, 9 figures, 7 tables, Accepted for publication in PASA

Pulsars have proven instrumental in exploring a wide variety of physics. Pulsars at low radio frequencies is crucial to further our understanding of spectral properties and emission mechanisms.The Murchison Widefield Array Voltage Capture System (MWA-VCS) has been routinely used to study and discover pulsars at low frequencies, offering the unique opportunity of recording complex voltages ,which can be off-line beamformed or imaged at millisecond time resolution.Devising imaged-based methods for finding pulsar candidates, which can be verified in beamformed data, can accelerate the complete process and lead to more pulsar detections by reducing the number of tied-array beams required, increasing compute resource efficiency.Despite a factor of ~4 loss in sensitivity, searching for pulsar candidates in images from the MWA-VCS, we can explore a larger parameter space, potentially leading to discoveries of pulsars missed by high-frequency surveys such as pulsars obscured in high-time resolution timeseries data by propagation effects.Image-based searches are also essential to probing parts of parameter space inaccessible to traditional beamformed searches with the MWA.In this paper we describe the innovative approach and capability of dual-processing MWA VCS data, i.e. finding pulsar candidates in these images, and verifying by forming tied-array beam.We developed and tested image-based methods of finding pulsar candidates, based on pulsar properties such as spectral index, polarisation and variability.The efficiency of these methodologies has been verified on known pulsars, and the main limitations explained in terms of sensitivity and low-frequency spectral turnover of some pulsars.No candidates were confirmed to be a new pulsar.This new capability will now be applied to multiple observations to accelerate pulsar discoveries with MWA and speed up future searches with the SKA-Low., 12 pages, 9 figures, accepted for publication in Publications of the Astronomical Society of Australia (PASA)

We present an overview of the Southern-sky MWA Rapid Two-metre (SMART) pulsar survey that exploits the MWA's large field of view and voltage capture system to survey the sky south of 30 degree in declination for pulsars and fast transients in the 140-170 MHz band. The survey is enabled by the advent of the Phase II MWA's compact configuration, which offers an enormous efficiency in beam-forming and processing costs, thereby making an all-sky survey of this magnitude tractable with the MWA. Even with the long dwell times of the survey (4800 s), data collection can be completed in < 100 hours of telescope time, while still retaining the ability to reach a limiting sensitivity of ~2-3 mJy. Each observation is processed to generate ~5000-8000 tied-array beams that tessellate the full ~610 square degree field of view, which are then processed to search for pulsars. The voltage-capture recording allows a multitude of post hoc processing options including the reprocessing of data for higher time resolution. Due to the substantial computational cost in pulsar searches at low frequencies, processing is undertaken in multiple passes: in the first pass, a shallow survey is performed, where 10 minutes of each observation is processed, reaching about one-third of the full search sensitivity. Here we present the system overview and initial results. Further details including first pulsar discoveries and a census of low-frequency detections are presented in a companion paper. Future plans include deeper searches to reach the full sensitivity and acceleration searches to target binary and millisecond pulsars. Simulation analysis forecasts ~300 new pulsars upon the completion of full processing. The SMART survey will also generate a complete digital record of the low-frequency sky, which will serve as a valuable reference for future pulsar searches planned with the low-frequency Square Kilometre Array., 22 pages, 12 figures, 2 tables, Accepted for publication in PASA

Energy communities are already part of the current Japanese energy sector. The enerugīkomyuniti (or enekomi, as I propose to call this type of entities) powered by renewables with an important role played by photovoltaics (PVs), reflect a growing wave of prosumer movements in Japan. This derives from the decrease in the cost of renewable installations, as well as the opportunities for multiple deployments in places previously unable to access renewable energy (such as farms – when ‘farming photovoltaics’ or ‘agrivoltaic systems’ are applied). The establishment of municipal power producers and suppliers (small-scale entities covering local areas), leading to broader popularization and use of distributed energy in Japan has also helped to promote this movement. However, any further development of enekomis requires the appropriate regulatory framework. Japan, which wants to promote the concept of a sustainable regional community internationally, must focus on amore preferential approach to enekomi. Based on the experience of the Member States, the European Union has managed to establish a model that could be implemented in Japan after a suitable adaptation. This applies in particular to the solutions offered to energy communities in Europe with respect to membership, non-discriminatory treatment, barriers, support schemes as well as grid connection and management. community energy, Japanese energy sector, enekomi, citizen energy communities, renewable energy communities, energy prosumers

Low-levels of Nb-doped (≤2 at.%) NBT ceramics were synthesized using a conventional ceramic technique. The XRD analysis indicated the formation of a perovskite structure with rhombohedral symmetry ...

We present the first observational study of pulsars performed with the second-generation precursor stations to the low-frequency component of the Square Kilometre Array (SKA-Low): the Aperture Array Verification System 2 (AAVS2) and the Engineering Development Array 2 (EDA2). Using the SKA-Low stations, we have observed 100 southern-sky pulsars between 70-350 MHz, including follow-up observations at multiple frequencies for a selected sample of bright pulsars. These observations have yielded detections of 22 pulsars, including the lowest-frequency detections ever published for 6 pulsars, despite the modest sensitivity of initial system where the recording bandwidth is limited to ~1 MHz. By comparing simultaneous flux density measurements obtained with the SKA-Low stations and performing rigorous electromagnetic simulations, we verify the accuracy of the SKA-Low sensitivity simulation code presented in Sokolowski et al. (2022). Furthermore, we perform model fits to the radio spectra of the detected pulsars using the method developed by Jankowski et al. (2018), including 9 pulsars which were not fitted in the original work. We robustly classify the spectra into 5 morphological classes and find that all but one pulsar exhibit deviations from simple power-law behaviour. These findings suggest that pulsars with well-determined spectra are more likely to show spectral flattening or turn-over than average. Our work demonstrates how SKA-Low stations can be meaningfully used for scientifically useful measurements and analysis of pulsar radio spectra, which are important inputs for informing pulsar surveys and science planned with the SKA-Low., 16 pages, 6 figures, 4 tables, accepted for publication in PASA

The Mn-substituted NBT ceramics were prepared by the conventional ceramic fabrication technique. X-ray diffraction (XRD) studies indicated the formation of perovskite phase with rhombohedral symmet...

With regard to suicidal behavior (SB) genetics, many novel genes have been implicated over the years, in particular by a variety of hypothesis-free genomic methods (e.g. GWAS and exome sequencing). In addition, many novel SB gene findings appear enigmatic in their biological relevance and have weak statistical support, e.g. lack direct replications. Adding to this is the comorbidity between psychiatric disorders and SB. Here we provide a synopsis of SB genes, by prioritization of 106 (out of ~2500) genes based on their highest level of evidence diversity across mainly five genetic evidence types (candidate/GWAS SNP, CNV, linkage and whole exome sequencing), supplemented by three functional categories. This is a representative set of both old and new SB gene candidates, implicated by all kinds of evidence. Furthermore, we define a subset of 40 SB "specific" genes, which are not found among ~3900 genes implicated in other neuropsychiatric disorders, e.g. Autism spectrum disorders (ASD) or Schizophrenia. Biological research of suicidality contains a major developmental focus, e.g. with regard to the gene-environment interactions and epigenetic effects during childhood. Less is known about early (fetal) development and SB genes. Inspired by huge efforts to understand the role early (fetal) neurodevelopment in e.g. ASD by using brain transcriptomic data, we here also characterize the 106 SB genes. We find interesting spatiotemporal expression differences and similarities between SB specific and non-specific genes during brain neurodevelopment. These aspects are of interest to investigate further, to better understand and counteract the genetic origins suicidality.

The conducted research shows that the EU-27 and the UK have a varied approach to electric scooters when it comes to law: some see them as means of micro-transportation or personal transport, others define them exclusively in their legislation (in a direct manner). In some countries electric scooters are not defined in legislation but other rules apply (e.g. rules on bicycles). Electric scooters’ users are qualified either as pedestrians using scooters, drivers, or cyclists. The limit of 20 – 25 km/h of speed is a general benchmark. The rules on the access to pavement, pedestrian zones, and pedestrian crossings vary among the Member States (some allow it, providing speed limits; others offer only the possibility of accessing bike paths or public roads). National legislation also provides some other requirements, such as age limits for electric scooter users when riding on a road or wearing protective equipment (e.g. helmet or safety vest). The research also proves that the majority of Member States do not provide any special rules on driving licences or insurance (generally not required when using electric scooters). Finally, the article addresses a seemingly basic legal European framework on electric scooters and a possible harmonization by adopting the Micromobility Directive. electric transport, electric scooters, micromobility, micro-transportation, Micromobility Directive

We present a low-frequency (170\textendash200\,MHz) search for prompt radio emission associated with the long GRB 210419A using the rapid-response mode of the Murchison Widefield Array (MWA), triggering observations with the Voltage Capture System (VCS) for the first time. The MWA began observing GRB 210419A within 89\,s of its detection by \textit{Swift}, enabling us to capture any dispersion delayed signal emitted by this GRB for a typical range of redshifts. We conducted a standard single pulse search with a temporal and spectral resolution of $100\,\upmu$s and 10\,kHz over a broad range of dispersion measures from 1 to $5000\,\text{pc}\,\text{cm}^{-3}$, but none were detected. However, fluence upper limits of $77\text{--}224$\,Jy\,ms derived over a pulse width of $0.5\text{--}10$\,ms and a redshift of $0.6, Comment: Accepted for publication in MNRAS

Here we present a low frequency (170-200MHz) search for coherent radio emission associated with nine short GRBs detected by the Swift and/or Fermi satellites using the Murchison Widefield Array (MWA) rapid-response observing mode. The MWA began observing these events within 30 to 60s of their high-energy detection, enabling us to capture any dispersion delayed signals emitted by short GRBs for a typical range of redshifts. We conducted transient searches at the GRB positions on timescales of 5s, 30s and 2min, resulting in the most constraining flux density limits on any associated transient of 0.42, 0.29, and 0.084Jy, respectively. We also searched for dispersed signals at a temporal and spectral resolution of 0.5s and 1.28MHz but none were detected. However, the fluence limit of 80-100Jy ms derived for GRB 190627A is the most stringent to date for a short GRB. We compared the fluence and persistent emission limits to short GRB coherent emission models, placing constraints on key parameters including the radio emission efficiency of the nearly merged neutron stars ($\lesssim10^{-4}$), the fraction of magnetic energy in the GRB jet ($\lesssim2\times10^{-4}$), and the radio emission efficiency of the magnetar remnant ($\lesssim10^{-3}$). Comparing the limits derived for our full GRB sample to the same emission models, we demonstrate that our 30-min flux density limits were sensitive enough to theoretically detect the persistent radio emission from magnetar remnants up to a redshift of $z\sim0.6$. Our non-detection of this emission could imply that some GRBs in the sample were not genuinely short or did not result from a binary neutron star merger, the GRBs were at high redshifts, these mergers formed atypical magnetars, the radiation beams of the magnetar remnants were pointing away from Earth, or the majority did not form magnetars but rather collapse directly into black holes., Accepted for publication in PASA

We present the system equivalent flux density (SEFD) expressions for all four Stokes parameters: I, Q, U, V. The expressions were derived based on our derivation of SEFD I (for Stokes I) and subsequent extensions of that work to phased array and multipole interferometers. The key to the derivation of the SEFD Q, U, V expressions is to recognize that the noisy estimates of Q, U, V can be written as the trace of a matrix product. This shows that the SEFD I is a special case, where the general case involves a diagonal or anti-diagonal 2x2 matrix interposed in the matrix multiplication. Following this step, the relation between the SEFD for I and Q, U, V becomes immediately evident. We present example calculations for a crossed dipole based on the formulas derived and the comparison between simulation and observation using the Murchison Widefield Array (MWA)., Comment: 6 pages, 4 figures. Accepted for publication in A&A on 25 May 2022

The SKA will be the largest radio astronomy observatory ever built, providing unprecedented sensitivity over a very broad frequency (50 MHz to 15.3 GHz). The SKA-Low (50 - 350 MHz), will be built at the MRO in Western Australia. It will consist of 512 stations each composed of 256 dual-polarised antennas, and the sensitivity of an individual station is pivotal to the performance of the entire SKA-Low telescope. The answer to the question in the title is, it depends. The sensitivity of a low frequency array, such as an SKA-Low station, depends strongly on the pointing direction of the digitally formed station beam and the local sidereal time (LST), and is different for the two orthogonal polarisations of the antennas. The accurate prediction of the SKA-Low sensitivity in an arbitrary direction in the sky is crucial for future observation planning. We present here a sensitivity calculator for the SKA-Low radio telescope, using a database of pre-computed sensitivity values for two realisations of an SKA-Low station architecture. One realisation uses the log-periodic antennas selected for SKA-Low. The second uses a known benchmark, in the form of the bowtie dipoles of the MWA. Data collected by both stations (deployed at the MRO in 2019) were used to measure their sensitivity at selected frequencies and over at least 24 h intervals, and were compared to the predictions described in this paper. The sensitivity values stored in the SQLite database were pre-computed for the X, Y and Stokes I polarisations in 10 MHz frequency steps, 0.5 hour LST intervals, and 5 degree resolution in pointing directions. The database allows users to estimate the sensitivity of SKA-Low for their favourite object using interactive web-based or command line interface, which can also calculate the sensitivity for arbitrary pointing directions, frequencies, and times without interpolations., 15 pages, 17 figures, Accepted for publication in PASA

The Murchison Widefield Array (MWA) is a low-frequency aperture array capable of high-time and frequency resolution astronomy applications such as pulsar studies. The large field-of-view of the MWA (hundreds of square degrees) can also be exploited to attain fast survey speeds for all-sky pulsar search applications, but to maximise sensitivity requires forming thousands of tied-array beams from each voltage-capture observation. The necessity of using calibration solutions that are separated from the target observation both temporally and spatially makes pulsar observations vulnerable to uncorrected, frequency-dependent positional offsets due to the ionosphere. These offsets may be large enough to move the source away from the centre of the tied-array beam, incurring sensitivity drops of $\sim$30-50\% in Phase II extended array configuration. We analyse these offsets in pulsar observations and develop a method for mitigating them, improving both the source position accuracy and the sensitivity. This analysis prompted the development of a multi-pixel beamforming functionality that can generate dozens of tied-array beams simultaneously, which runs a factor of ten times faster compared to the original single-pixel version. This enhancement makes it feasible to observe multiple pulsars within the vast field of view of the MWA and supports the ongoing large-scale pulsar survey efforts with the MWA. We explore the extent to which ionospheric offset correction will be necessary for the MWA Phase III and the low-frequency Square Kilometre Array (SKA-Low)., 10 pages, 5 figures

This paper extends the treatment of system equivalent flux density (SEFD) in Sutinjo, A. T. et al. (2021) (Paper I) to interferometric phased array telescopes. The objective is to develop an SEFD formula involving only the most fundamental assumptions and one that is readily applicable to phased array interferometer radio observations. Then, we aimed at comparing the resultant SEFD expression against the often-used root-mean-square (RMS) SEFD approximation, SEFDrmsI = (1/2)(SEFD^2_XX + SEFD^2_YY)^(1/2) to study the inaccuracy of the SEFDrms. We take into account all mutual coupling and noise coupling within an array environment (intra-array coupling). This intra-array noise coupling is included in the SEFD expression through the realized noise resistance of the array, which accounts for the system noise. No assumption is made regarding the polarization (or lack thereof) of the sky nor the orthogonality of the antenna elements. The fundamental noise assumption is that, in phasor representation, the real and imaginary components of a given noise source are independent and equally distributed (iid) with zero mean. Noise sources that are mutually correlated and non-iid among themselves are allowed, provided the real and imaginary components of each noise source are iid. The system noise is uncorrelated between array entities separated by a baseline distance, which in the case of the Murchison Widefield Array (MWA) is typically tens of wavelengths or greater. By comparing the resulting SEFD formula to the SEFD_I^rms approximation, we proved that SEFD_I^rms always underestimates the SEFD, which leads to an overestimation of array sensitivity., Comment: Accepted for publication in Astronomy & Astrophysics (30 Jan. 2022). 15 pages

The present study examined the factor structure of the Personality Assessment Inventory Antisocial Features scale (PAI-ANT) in a non-forensic sample of 1257 undergraduate students. One to four-factor models were tested using exploratory factor analysis (EFA), with a four-factor solution exhibiting the best fitting model (Bentler 1995). Next examined was the convergent and discriminant validity of the PAI-ANT. Results indicated that the PAI-ANT four-factor model was significantly related to measures of general personality, pride, impulsivity, and attachment. Comparisons between the original three-factor model (as proposed by Morey 2007) and our derived four-factor model showed that both models generally had the expected pattern of relations for their respective factors although mixed findings were found for the sensation seeking and risk-taking scales. Findings for these scales indicated that individuals could crave excitement and also have some positive characteristics. The current findings suggest that the four-factor model of the PAI is the best way to interpret the PAI psychopathy scale, but that some caution is needed in interpreting the sensation seeking and risk-taking scales.

Muscle mass is a commonly cited mediator of the relationship between physical activity (PA) and bone, representing the mechanical forces generated during PA. However, neuromuscular properties (eg, peak force) also account for unique portions of variance in skeletal outcomes. We used serial multiple mediation to explore the intermediary role of muscle mass and force in the relationships between cortical bone and moderate-to-vigorous intensity PA (MVPA). In a cross-sectional sample of young adults (n = 147, 19.7 ± 0.7 years old, 52.4% female) cortical diaphyseal bone was assessed via peripheral quantitative computed tomography at the mid-tibia. Peak isokinetic torque in knee extension was assessed via Biodex dynamometer. Thigh fat-free soft tissue (FFST) mass, assessed via dual-energy X-ray absorptiometry, represented the muscular aspect of tibial mechanical forces. Habitual MVPA was assessed objectively over 7 days using Actigraph GT3X+ accelerometers. Participants exceeded MVPA guidelines (89.14 ± 27.29 min/day), with males performing 44.5% more vigorous-intensity activity relative to females (p

The article juxtaposes the regulatory approach to small renewable energy sources and energy communities in the European Union, Australia, and New Zealand, highlighting such matters as the nature, character, and scope of the regulatory model of renewable energy sector. The paper also analyses energy communities in the past, current and drafted European law (as in the "Clean Energy for all Europeans" package) as well as discussing relevant legislation and policies on small renewable energy sources and energy communities in Australia and New Zealand. In this context, this article reviews the possibility of exporting the European model on energy communities outside the EU.

Suicidal behavior (SB) has a complex etiology involving different polygenic and environmental components. Here we used an excess of significant markers (ESM) test to study gene-level associations in previous genome-wide association studies (GWAS) SNP data from a family-based sample, having medically severe suicide attempt (SA) as main outcome in the offspring. In SA without major psychiatric disorders (N = 498), a screening of 5,316 genes across the genome suggested association 17 genes (at fdr < 0.05). Genes RETREG1 (a.k.a. FAM134B), GSN, GNAS, and CACNA1D were particularly robust to different methodological variations. Comparison with the more widely used Multi-marker Analysis of GenoMic Annotation (MAGMA) methods, mainly supported RETREG1, GSN, RNASEH2B, UBE2H, and CACNA1D by using the "mean" model, and ranked 13 of the same genes as ESM among its top-17. Complementing the ESM screen by using MAGMA to analyze 17,899 genes, we observed excess of genes with p < .05 by using the "top" model, and the "mean" model suggested additional genes with genome-wide fdr < 0.25. Overrepresentation analysis of 10 selected gene sets using all genes with p < .05, showed significant results for synaptic genes, genes differentially expressed in brain development and for ~12% of the SA polygenic association genes identified previously in this sample. Exploratory analysis linked some of the ESM top-17 genes to psychotropic drugs and we examined the allelic heterogeneity in the previous SA candidate GRIN2B. This study complemented previous GWAS on SB outcomes, implicating both previous candidate (e.g., GRIN2B and GNAS) and novel genes in SA outcomes, as well as synaptic functions and brain development.

The low-lead (1-x)Pb(Mg1/3Nb2/3)O3-xBaTiO3 (x = 0, 0.025, 0.05, 0.075, 0.10 and 0.15) ceramics were fabricated by a two-step solid-state reaction route. The X-ray diffraction characterization confi...

PURPOSE Muscle cross-sectional area (MCSA) is often used as a surrogate for the forces applied to bones during physical activity. Although MCSA is a strong predictor of cortical bone status, its use makes assumptions about the relationship between muscle size and force that are inaccurate. Furthermore, to measure MCSA and other muscle force surrogates typically requires expensive and/or radiative laboratory equipment. Thus, this study aimed to determine whether clinical laboratory- and field-based methodologies for measuring muscular force capacity accounted for similar variance in diaphyseal cortical bone status as a commonly used muscular force surrogate, MCSA, at the midtibia in young men and women. METHODS Healthy young adults (n = 142, 19.7 ± 0.7 yr old, 52.8% female) were assessed via peripheral quantitative computed tomography at the midtibia for cortical bone status and MCSA. Muscle force capacity was measured via Biodex dynamometer, Nottingham leg extensor power rig, and Vertec vertical jump. Regression analysis compared the independent variance predicted by each muscle force measure with that of MCSA, accounting for relevant confounders. RESULTS MCSA, knee extension peak torque, and peak anaerobic power from vertical jump were independent predictors of select cortical structural outcomes (cortical thickness and area, periosteal and endosteal circumference, and estimated strength) accounting for up to 78.4% of the variance explained (all P < 0.05). However, cortical volumetric bone mineral density was unrelated to any measure or surrogate of muscle force capacity. CONCLUSIONS MCSA is a strong independent predictor of cortical bone structure; however, both laboratory- and field-based measures of peak torque and/or peak anaerobic power are promising alternatives, explaining similar and sometimes greater variance than MCSA.

In 2016, the European Commission presented a legislative package: "Clean Energy for all Europeans", with the proposal for a new Directive on common rules for the internal market in electricity (recast) as its part. The package is aimed at setting consumers as the "active and central players on the energy markets of the future". This issue is subjected to the analysis in this paper, which is intended to discuss its collective approach, i.e. the generation of electricity in energy communities. The research covers the analysis of previous European policy documents and programmes, repealed and to be amended legislation that indirectly addresses (or could address) the issue of energy communities, as well as the legislation that will regulate (or may regulate) it directly (i.e. the new Directive on common rules for the internal market in electricity). Seen in this light, the paper is aimed at proving that the idea for cooperation of energy consumers and local production of electricity from renewable energy sources, is deeply rooted in the European agenda for the internal energy market.

Information about genes and the biology of suicidal behavior (SB) is noisy due to heterogenous outcomes (suicide attempts or deaths), as well as many different genes and overlapping biological processes implicated. One approach to test the unbiased biological coherence of disease genes, is to use genes from hypothesis-free genetic scans and to investigate if they aggregate close to each other in cellular gene and protein interaction networks (“interactomes”). Therefore, we used network methods to study the biological coherence among genes (n = 229) from genome-wide association studies (GWAS) and whole exome sequencing (WES) of suicide outcome. Results showed that the suicide GWAS+WES genes has significant aggregation in three major interactome database assemblies, a hallmark of biological similarity and increased likelihood of being involved in the same outcome (suicide). This pinpointed e.g. genes on chromosome 19, which are also associated with lipid metabolism, schizophrenia and bipolar disorder. We identified a subset of GWAS+WES “core” genes (n = 54) which are the most proximal to each other in the context of three interactome assemblies, and present a candidate network module of suicide which is specific for nervous system tissues. The n = 54 most proximal “core” genes showed overrepresentation of synaptic and nervous system development genes, as well as network paths to other SB genes having increased evidence diversity. Overall, results suggested the existence of a coherent biology in suicide outcome and provide unbiased biological support concerning links to other SB genes, as well as e.g. bipolar disorder, excitatory/inhibitory function and ketamine treatment in SB.

Two types of lead-free Na 0.5 Bi 0.5 TiO 3 ceramics were manufactured by using a high-temperature solid-state reaction technique. X-ray diffraction analysis showed the formation of a single perovskite phase with the rhombohedral symmetry at room temperature. The structural, vibrational, dielectric and ferroelectric properties of these ceramics in unpoled and poled states were investigated. It was shown that a prior E-field poling process significantly influences the properties of these ceramics. This includes changes in the character of e(T)- and tanδ(T) plots, P(E) hysteresis loops, as well as shifts of T d and T R-T . These effects are mainly attributed to the improvement of polarization/domain ordering and transformation of tetragonal regions into rhombohedral phase by applied electric field. This is accompanied by a change of rhombohedral lattice distortion and a change of unit cell constants. The electric field supported and extended the ferroelectric phase existence towards higher temperatures.

// Daniel Walden 1 , Selvi Kunnimalaiyaan 1 , Kevin Sokolowski 1 , T. Clark Gamblin 1 and Muthusamy Kunnimalaiyaan 1 1 Division of Surgical Oncology, Department of Surgery, MCW Cancer Center, Translational and Biomedical Research Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA Correspondence to: Muthusamy Kunnimalaiyaan, email: mkunnima@mcw.edu Keywords: cholangiocarcinoma, xanthohumol, Notch1, apoptosis, cell cycle Received: July 06, 2017 Accepted: August 31, 2017 Published: September 30, 2017 ABSTRACT Cholangiocarcinoma remains the second most prevalent hepatic neoplasm in the United States with a 5-year survival rate of less than 10%. Currently, no systemic therapy has demonstrated efficacy. Therefore, an urgent need for the identification of molecularly targeted compound(s) remains. The Notch signaling pathway has been shown to be dysregulated in cholangiocarcinoma, exhibiting hyperactivity while also possibly mediating chemotherapeutic resistance. We analyzed the effects of xanthohumol, a prenylated chalcone, on cholangiocarcinoma proliferation utilizing human cholangiocarcinoma cell lines CCLP1, SG-231 and CC-SW-1 while gaining insight into the associated mechanism. Xanthohumol potently reduced cellular proliferation, colony formation, and cell confluency in all three cell lines. Xanthohumol induced cell cycle arrest as well as apoptosis through the reduction of cell cycle regulatory proteins as well as an increase in pro-apoptotic markers (cleaved poly ADP ribose polymerase, cleaved caspase-3) and a decrease in anti-apoptotic markers (X-linked inhibitor of apoptosis and survivin). At the molecular level, xanthohumol reduced Notch1 and AKT expression in a step-wise and time-dependent fashion, with Notch1 reductions preceding AKT. Additionally, xanthohumol reduced cholangiocarcinoma growth in both CCLP-1 and SG-231 derived mice xenografts. In summary, we show that xanthohumol significantly reduced cholangiocarcinoma growth through the Notch1/AKT signaling axis. Furthermore, known pharmacokinetics and bioavailability of XN supports continued development of treatment for cholangiocarcinoma.

Na0.5Bi0.5TiO3 ceramics were prepared by a conventional solid-state reaction method and by a hot-pressing route. The influence of sintering conditions on structural, thermal, dielectric and ferroelectric properties of these ceramics was investigated. All obtained samples exhibited a single perovskite phase. It was shown that the sintering conditions significantly influence the properties under investigation. This includes changes in the value of the electric permittivity ϵ and dielectric loss tanδ, a shift of Tm and Td and change of the ferroelectric properties. These effects are mainly related to volatility of the Na and Bi components during the sintering process along with formation of their compensating charge defects, which leads to local structure change.

Suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, has preclinical efficacy in hepatocellular carcinoma (HCC), despite an unclear molecular mechanism. We sought to further investigate the effects of SAHA on HCC. We hypothesize SAHA will inhibit HCC cellular proliferation through apoptosis and aid in further profiling SAHA's effect on HCC oncogenic pathways.HCC cell lines were treated with various concentrations of SAHA. Cell proliferation was determined by MTT and colonogenic assays. Cell lysates were analyzed via Western blotting for apoptotic and oncogenic pathway markers. Caspase glo-3/7 was used to assess apoptosis.SAHA treatment demonstrated significant (0.05) reduction in cell growth and colony formation through apoptosis and cell cycle arrest. Western analysis showed reduction in Notch, pAKT and pERK1/2 proteins. Interestingly, phosphorylated STAT3 was increased in all cell lines.SAHA inhibits Notch, AKT, and Raf-1 pathways but not the STAT3 pathway. We believe that STAT3 may lead to cancer cell progression, reducing SAHA efficacy in HCC. Therefore, combination of SAHA and STAT or Notch inhibition may be a strategy for HCC treatment.

The chapter presents an overview of the basic results of studies on potassium-bismuth titanate K0.5Bi0.5TiO3. The investigations relate to four samples prepared in different technological conditions. The results of density test using the Archimedes method and the results of microstructure research using high-resolution scanning electron microscopy SEM and chemical composition using the EDS technique are presented. The identification of the structure of the study materials was carried out using X-ray diffraction. Results of dielectric permeability study were presented.

Overall diet quality is a key predictor of disease risk and mortality. Diets higher in animal protein have been associated with increased disease risk and all-cause mortality. However, the source of protein consumed will inevitably influence the intake of other macronutrients and micronutrients which can also play a role in the onset of disease. The aim of the present study was to assess the relationship between animal and plant protein intake and overall diet quality in young adult females and males.Dietary intake was assessed via 3-day food log (n = 150; 53% females) and data were analyzed using the Nutrition Data Systems for Research (NDSR).Females and males consuming70% of their protein from animal sources had higher scores on a modified Healthy Eating Index (HEI) compared those consuming70% of their protein from animal sources. Males scored lower than females on the modified HEI regardless of protein source intake variation.Our findings suggest that overall diet quality differs with varying protein source consumption and eating70% of protein from animal sources might lead to a better score on the HEI. Future research investigating protein source and disease risk should examine overall dietary quality as a potential effect modifier.

Good quality ceramics of (1−x)Na0.5Bi0.5TiO3(NBT)−xPbTiO3 (PT) (x = 0, 0.03 and 0.05) were prepared by a conventional solid-phase sintering process. The temperature dependence of the dc, ac conductivity (σdc, σac, respectively), the Seebeck coefficient (α), the concentration of charge carriers n and their mobility μ were investigated. The dc conductivity for pure NBT possesses three linear parts with three different activation energies Ea. For 0.97NBT–0.03PT and 0.95NBT--0.05PT ceramics, the dc conductivity also has three linear parts (three different Ea). On the other hand, the ac conductivity possesses three linear parts for pure NBT and four for other compositions. The possible origin of the observed effects is discussed. We suggest that the presented materials can be a good starting point for the development of low-lead electronic ceramics.

Background We have shown that an Akt inhibitor, MK2206, reduces hepatocellular carcinoma (HCC) proliferation. To further delineate MK2206, we sought to investigate the Notch1 pathway and hypothesize that MK2206 treatment will result in Notch1 inhibition with either subsequent or parallel Akt suppression. Methods HCC cell lines were treated with various concentrations of MK2206. Cell proliferation was determined via real-time live cell imaging. Knockdown of Notch1 was used to observe interaction between Notch1 and pAkt. Cell lysates were analyzed via Western blotting for Notch and Akt pathway targets. Results After treatment with MK2206 (up to 2 μM), there was a 60% reduction in cell viability at 48 hours with a concomitant reduction in Notch1 expression. Knockdown of Notch1 in HCC cell lines correlated with reduction in Akt phosphorylation. Conclusions MK2206 inhibits both the PI3-K/Akt and Notch1 pathways. Therefore, further characterization of MK2206 comparing the 2 pathways is warranted and the effect of dual targeting in HCC.

High quality lead-free Na0.5Bi0.5TiO3 (NBT) single crystals were grown by the Czochralski method. The XRD patterns indicate the perovskite-type structure of rhombohedral symmetry with small amount of tetragonal phase even at room temperature. Structural, Raman scattering, thermal, dielectric and second harmonic generation (SHG) studies were performed for both unpoled and poled samples. The observed features indicate that the electric field applying significantly affects the polar state and causes the increase of a local degree of order and transformation of the tetragonal regions into the rhombohedral phase, and in consequence stabilizes and widens the temperature range of the ferroelectric state. The hysteresis loop, pyroelectric and SHG measurements indicated that in controversial temperature interval (∼200–350 °C) NBT exhibits ferroelectric nature rather than antiferroelectric one, and polar state presence up to approximately 400 °C. Anomalies of the temperature dependences of heat flow (DSC) and thermal expansion (Δl/l0) observed at approximately 165, 330 and 540 °C are connected with so called “depolarization temperature” Td and the phase transitions between the rhombohedral, tetragonal and cubic majority phases, respectively.