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1. Genetic epidemiology of diabetes with onset within one year of life

Author

IAFUSCO, Dario, M. A. Stazi, R. Cotichini, M. Cotellessa, M. E. Martinucci, M. Mazzella, V. Cherubini, F. Cerutti, F. Prisco, Italian Study Group on Early Onset Diabetes of ISPED, Iafusco, Dario, M. A., Stazi, R., Cotichini, M., Cotellessa, M. E., Martinucci, M., Mazzella, V., Cherubini, F., Cerutti, F., Prisco, and Italian Study Group on Early Onset Diabetes of, Isped

Published
2001

2. Risk of type 1 diabetes development in children with incidental hyperglycemia (multicenter Italian Study)

Author

R. LORINI, A. ALIBRANDI, L. VITALI, C. KLERSY, M. MARTINETTI, C. BETTERLE, G. DANNUNZIO, E. BONIFACIO, V. CHERUBINI, L. CAVALLO, F. DAMMACCO, G. CERASOLI, M. POCECCO, S. TUMINI, F. CHIARELLI, M. MANCUSO, P. BANIN, S. TONI, M. MARTINUCCI, C. BARELLA, M. COTELLESSA, A. MONACI, F. LOMBARDO, F. MESCHI, G. CHIUMELLO, L. IUGHETTI, S. BERNASCONI, F. PRISCO, A. FRANZESE, F. CADARIO, F. CARDELLA, C. MONCIOTTI, R. GIACCHERO, MA AVANZINI, MAL CRESPIN, L. CALISTI, G. CHIARI, M. VANELLI, L. GUAZZAROTTI, N. SULLI, G. MULTARI, A. CRINÒ, G. MARIETTI, S. PICCININI, ML MANCA BITTI, P. SACCHINI, A. MARSCIANI, C. SACCHETTI, F. CERUTTI, G. TONINI, A. VISENTIN, G. CONTREAS, L. PINELLI, IAFUSCO, Dario, R., Lorini, A., Alibrandi, L., Vitali, C., Klersy, M., Martinetti, C., Betterle, G., Dannunzio, E., Bonifacio, V., Cherubini, L., Cavallo, F., Dammacco, G., Cerasoli, M., Pocecco, S., Tumini, F., Chiarelli, M., Mancuso, P., Banin, S., Toni, M., Martinucci, C., Barella, M., Cotellessa, A., Monaci, F., Lombardo, F., Meschi, G., Chiumello, L., Iughetti, S., Bernasconi, Iafusco, Dario, F., Prisco, A., Franzese, F., Cadario, F., Cardella, C., Monciotti, R., Giacchero, Ma, Avanzini, Mal, Crespin, L., Calisti, G., Chiari, M., Vanelli, L., Guazzarotti, N., Sulli, G., Multari, A., Crinò, G., Marietti, S., Piccinini, ML MANCA, Bitti, P., Sacchini, A., Marsciani, C., Sacchetti, F., Cerutti, G., Tonini, A., Visentin, G., Contrea, and L., Pinelli

Published
2001

3. Rischio di diabete al di sotto del primo anno di vita: Sardegna versus resto d’Italia

Author

Cherubini V, P. Frongia, M. Songini, A. Ogana, F. Carle, M. Cotellessa, E. de Conciliis, A. iannilli, R. Dhamo, G. V. Coppa Gruppo di Studio SIEDP F. Chiarelli, L. Bellu, A. R. Fifi, L. Cavallo, E. Frezza, E. Piccinno, A. Vergerio, E. Cacciari, S. Salardi, E. Angius, C. Pintor, A. La Loggia, M. Cicchetti, G. Reitano, M. Mancuso, M. Pocecco, G. Cerasoli, A. Verrotti, R. Vanini, L. Spallino, A. Vaccà, P. Banin, S. Toni, R. Lorini, P. Picco, A. Monaci, F. De Luca, F. Lombardo, G. Chiumello, F. Meschi, S. Bernasconi, S. Mariani, A. Franzese, O. Stoppoloni, Bona, C. Monciotti, F. Cardella, M. Vanelli, G. Chiari, G. D’Annunzio, G. De Giorgi, L. Calisti, G. Zanette, E. Bartolotta, A. Crinò, L. Lucentini, I. P. Patera, G. Marietti, G. Multari, N. Sulli, A. M. Marinaro, A. Falorni, I. Rabbone, V. Cauvin, A. Visentin, G. Tonini, E. Buratti, P. Salvatoni, L. Pinelli, IAFUSCO, Dario, Cherubini, V, Iafusco, Dario, P., Frongia, M., Songini, A., Ogana, F., Carle, M., Cotellessa, E., de Concilii, A., Iannilli, R., Dhamo, G. V. Coppa Gruppo di Studio SIEDP F., Chiarelli, L., Bellu, A. R., Fifi, L., Cavallo, E., Frezza, E., Piccinno, A., Vergerio, E., Cacciari, S., Salardi, E., Angiu, C., Pintor, A., La Loggia, M., Cicchetti, G., Reitano, M., Mancuso, M., Pocecco, G., Cerasoli, A., Verrotti, R., Vanini, L., Spallino, A., Vaccà, P., Banin, S., Toni, R., Lorini, P., Picco, A., Monaci, F., De Luca, F., Lombardo, G., Chiumello, F., Meschi, S., Bernasconi, S., Mariani, A., Franzese, O., Stoppoloni, Bona, C., Monciotti, F., Cardella, M., Vanelli, G., Chiari, G., D’Annunzio, G., De Giorgi, L., Calisti, G., Zanette, E., Bartolotta, A., Crinò, L., Lucentini, I. P., Patera, G., Marietti, G., Multari, N., Sulli, A. M., Marinaro, A., Falorni, I., Rabbone, V., Cauvin, A., Visentin, G., Tonini, E., Buratti, P., Salvatoni, and L., Pinelli

Published
1999

4. L’incidenza del diabete tipo 1 al di sotto del primo anno di vita. Sardegna versus resto d’Italia

Author

Cherubini V, Frongia P, M. Songini, A. Ogada, F. Carle, M. Cotellessa, E. De Conciliis e. Gruppo di Studio di Diabetologia Pediatrica F. Chiarelli, U. Iannilli, R. Dhamo, A. Pinelli, GV Coppa, L. Bellu, A. R. Fifi, L. Cavallo, E. Frezza, E. Piccinno, A. Vergerio, E. Cacciari, S. Salardi, E. Angius, P. Frongia, C. Pintor, A. La Loggia, M. Cicchetti, G. Reitano, M. Mancuso, ML Arpi, M. Pocecco, G. Cerasoli, A. Verrotti, E. Altobelli, R. Vanini, L. Spallino, A. Vaccà, P. Banin, S. Toni, R. Lorini, P. Picco, A. Monaci, F. De Luca, F. Lombardo, G. Chiumello, F. Meschi, S. Bernasconi, S. Mariani, A. Franzese, O. Stoppoloni, F. Prisco, Bona, C. Monciotti, F. Cardella, M. Vanelli, G. Chiari, G. D’Annunzio, G. De Giorgi, L. Calisti, G. Zanette, E. Bartolotta, A. Crinò, L. Lucentini, I. P. Patera, G. Marietti, G. Multari, N. Sulli, A. M. Marinaro, A. Falorni, F. Cerutti, I. Rabbone, Bruno, V. Cauvin, A. Visentin, G. Tonini, E. Buratti, P. Salvatoni, L. Pinelli, IAFUSCO, Dario, Cherubini, V, Iafusco, Dario, Frongia, P, M., Songini, A., Ogada, F., Carle, M., Cotellessa, E. De Conciliis e. Gruppo di Studio di Diabetologia Pediatrica F., Chiarelli, U., Iannilli, R., Dhamo, A., Pinelli, Gv, Coppa, L., Bellu, A. R., Fifi, L., Cavallo, E., Frezza, E., Piccinno, A., Vergerio, E., Cacciari, S., Salardi, E., Angiu, P., Frongia, C., Pintor, A., La Loggia, M., Cicchetti, G., Reitano, M., Mancuso, Ml, Arpi, M., Pocecco, G., Cerasoli, A., Verrotti, E., Altobelli, R., Vanini, L., Spallino, A., Vaccà, P., Banin, S., Toni, R., Lorini, P., Picco, A., Monaci, F., De Luca, F., Lombardo, G., Chiumello, F., Meschi, S., Bernasconi, S., Mariani, A., Franzese, O., Stoppoloni, F., Prisco, Bona, C., Monciotti, F., Cardella, M., Vanelli, G., Chiari, G., D’Annunzio, G., De Giorgi, L., Calisti, G., Zanette, E., Bartolotta, A., Crinò, L., Lucentini, I. P., Patera, G., Marietti, G., Multari, N., Sulli, A. M., Marinaro, A., Falorni, F., Cerutti, I., Rabbone, Bruno, V., Cauvin, A., Visentin, G., Tonini, E., Buratti, P., Salvatoni, and L., Pinelli

Published
1999

5. Esiste un’età 'cut-off' al di sotto della quale è improbabile il diabete autoimmune ?

Author

IAFUSCO, Dario, F. Prisco, MA Stazi, M. Cotellessa, M. Mazzella, F. Cerutti, ME Martinucci, V. Cherubini, G. Tosi, R. Accolla e. il Gruppo di Lavoro sul Diabete ad insorgenza precoce della SIEDP, Iafusco, Dario, F., Prisco, Ma, Stazi, M., Cotellessa, M., Mazzella, F., Cerutti, Me, Martinucci, V., Cherubini, G., Tosi, and R. Accolla e., il Gruppo di Lavoro sul Diabete ad insorgenza precoce della SIEDP

Published
1999

6. Transient focal neurologic deficits associated with hypoglycemia in children with insulin-dependent diabetes mellitus

Author

M. POCECCO, R. RONFANI, R. BERARDI, S. BERNASCONI, S. MARIANI, E. BURATTI, C. MILOCCO, E. CACCIARI, S. SALARDI, F. CADARIO, L. CALISTI, G. CERASOLI, F. CERUTTI, V. CHERUBINI, F. CHIARELLI, A. VERROTTI, M. COTELLESSA, M. MAZZELLA, A. CRINÒ, F. DE LUCA, V. DE SANCTIS, P. BANIN, A. FRANZESE, L. GARGANTINI, E. SANPELLEGRINO, F. PRISCO, G. DANNUNZIO, L. LUCENTINI, G. MARIETTI, A. MARSCIANI, M. MARTINUCCI, C. MONCIOTTI, A. OGANA, P. PICCO, M. SCATTONI, L. SPALLINO, R. VANINI, L. STOCCHERO, M. VANELLI, G. CHIARI, A. VISENTIN, IAFUSCO, Dario, M., Pocecco, R., Ronfani, R., Berardi, S., Bernasconi, S., Mariani, E., Buratti, C., Milocco, E., Cacciari, S., Salardi, F., Cadario, L., Calisti, G., Cerasoli, F., Cerutti, V., Cherubini, F., Chiarelli, A., Verrotti, M., Cotellessa, M., Mazzella, A., Crinò, F., DE LUCA, V., DE SANCTIS, P., Banin, A., Franzese, L., Gargantini, E., Sanpellegrino, Iafusco, Dario, F., Prisco, G., Dannunzio, L., Lucentini, G., Marietti, A., Marsciani, M., Martinucci, C., Monciotti, A., Ogana, P., Picco, M., Scattoni, L., Spallino, R., Vanini, L., Stocchero, M., Vanelli, G., Chiari, and A., Visentin

Published
1998

7. Incidenza e prevalenza di MODY in una popolazione pediatrica (studio multicentrico)

Author

R. Lorini, L. Vitali, A. Alibrandi, V. Cherubini, L. Cavallo, A. Marsciani, G. Cerasoli, F. Chiarelli, P. Banin, S. Toni, M. Martinucci, M. Pelegrini, M. Cotellessa, P. Picco, A. Monaci, F. lombardo, F. Meschi, S. Bernasconi, F. Prisco, A. Franzese, F. Cadario, C. Monciotti, F. Cardella, G. Chiari, M. Vanelli, D. d’Annunzio, L. Calisti, L. Guazzarotti, P. sacchini, N. Sulli, G. Multari, A. Crinò, G. Marietti, A. Falorni, F. Cerutti, A. Visentin, C. Klersì, F. Barbetti, C. Bellanè Chantelot, IAFUSCO, Dario, R., Lorini, L., Vitali, A., Alibrandi, V., Cherubini, L., Cavallo, A., Marsciani, G., Cerasoli, F., Chiarelli, P., Banin, S., Toni, M., Martinucci, M., Pelegrini, M., Cotellessa, P., Picco, A., Monaci, F., Lombardo, F., Meschi, S., Bernasconi, Iafusco, Dario, F., Prisco, A., Franzese, F., Cadario, C., Monciotti, F., Cardella, G., Chiari, M., Vanelli, D., D’Annunzio, L., Calisti, L., Guazzarotti, P., Sacchini, N., Sulli, G., Multari, A., Crinò, G., Marietti, A., Falorni, F., Cerutti, A., Visentin, C., Klersì, F., Barbetti, and C., Bellanè Chantelot

Published
1998

8. Incidence and Prevalence of MODY: A Multicentre Italian Study

Author

R. Lorini, L. Vitali, A. Alibrandi, V. Cherubini, L. Cavallo, A. Marsciani, G. Cerasoli, F. Chiarelli, P. Banin, S. Toni, M. Martinucci, M. Pelegrini, M. Cotellessa, P. Picco, F. Lombardi, F. Meschi, S. Bernasconi, F. Prisco, A. Franzese, F. Cadario, F. Cardella, G. Chiari, M. Vanelli, C. Monciotti, L. Calisti, L. Guazzarotti, P. Sacchini, N. Sulli, G. Multari, A. crinò, G. Marietti, A. Falorni, F. Cerutti, A. Visentin, C. Klersì, F. Barbetti, C. Bellanè Chantelot, IAFUSCO, Dario, R., Lorini, L., Vitali, A., Alibrandi, V., Cherubini, L., Cavallo, A., Marsciani, G., Cerasoli, F., Chiarelli, P., Banin, S., Toni, M., Martinucci, M., Pelegrini, M., Cotellessa, P., Picco, F., Lombardi, F., Meschi, S., Bernasconi, Iafusco, Dario, F., Prisco, A., Franzese, F., Cadario, F., Cardella, G., Chiari, M., Vanelli, C., Monciotti, L., Calisti, L., Guazzarotti, P., Sacchini, N., Sulli, G., Multari, A., Crinò, G., Marietti, A., Falorni, F., Cerutti, A., Visentin, C., Klersì, F., Barbetti, and C., Bellanè Chantelot

Published
1998

9. Breastfeeding in Northern Italy

Author

Corciulo M, Caviglia Mr, Malvasio S, M. Cotellessa, Santini P, Schiavetti P, Asprea T, Maria Grazia Calevo, Boscarini A, Serra G, Corona Mf, Renda R, W. Bonacci, Revello G, and Ivaldi M

Subjects
Adult, Pediatrics, medicine.medical_specialty, Time Factors, Adolescent, Breastfeeding, Birthing Centers, World health, Pregnancy, Surveys and Questionnaires, Epidemiology, Medicine, Humans, Prospective Studies, business.industry, Public health, Infant, Newborn, Infant, General Medicine, Northern italy, Parity, Breast Feeding, Italy, Pediatrics, Perinatology and Child Health, Cohort, Educational Status, Observational study, Female, business, Breast feeding, Demography, Maternal Age
Abstract

Aim: To describe the duration and type, as classified by World Health Organization (WHO) criteria, of breastfeeding in Ligurian newborns up to 1 year of age, and to identify possible related factors. Methods: A prospective, observational study on a cohort of 757 women recruited in 10 hospitals in Northern Italy. Women were followed up by means of a questionnaire at discharge and by telephone interviews in the 4th, 12th, 24th and 48th weeks postpartum using the ‘recall period’ method. Results: At discharge, 97.3% of mothers had started breastfeeding; regional breastfeeding rates at the 4th, 12th, 24th and 48th weeks were respectively 84.4%, 71.2%, 54.4% and 26.3%. Socio-demographic factors did not significantly influence these percentages. Median duration of breastfeeding was 6.5 months. No statistically significant differences were observed in duration of breastfeeding between women who started exclusive breastfeeding (EBF) and those who did predominant breastfeeding (PBF), while the difference was statistically significant when comparing complementary breastfeeding (CBF) with EBF and with PBF. Conclusions: Our study is the first regional experience in the Liguria region and represents a starting point for the diffusion of the culture of breastfeeding. Our results are satisfactory with regards to the overall duration of breastfeeding until the first year of life (26.3%), while duration of EBF (9.5% at the 24th week) is still unsatisfactory according to WHO objectives that include EBF for all children up to the sixth month of life.

Published
2008

10. Difetti neurologici focali transitori associati ad ipoglicemia in bambini con diabete mellito insulino dipendente

Author

M. Pocecco, L. Ronfani, R. Berardi, S. Bernasconi, S. Mariani, E. Cacciari, S. Salardi, F. Cadario, L. Calisti, G. Cerasoli, F. Cerutti, V. Cherubini, A. Iannilli, F. Chiarelli, A. Verrotti, M. Cotellessa, M. Mazzella, A. Crinò, G. De Giorgi, F. De Luca, F. Lombardo, V. De Santis, P. Banin, A. Franzese, L. Gargantini, E. Sampellegrini, R. Lorini, G. D’Annunzio, L. Lucentini, G. Marietti, A. Marsciani, M. Martinucci, C. Monciotti, A. Ogana, P. Picco, F. Prisco, Scattoni M, L. Spallino, R. Vanini, L. Stocchero, m. Vanelli, G. Vhiari, A. Visentin, IAFUSCO, Dario, M., Pocecco, L., Ronfani, R., Berardi, S., Bernasconi, S., Mariani, E., Cacciari, S., Salardi, F., Cadario, L., Calisti, G., Cerasoli, F., Cerutti, V., Cherubini, A., Iannilli, F., Chiarelli, A., Verrotti, M., Cotellessa, M., Mazzella, A., Crinò, G., De Giorgi, F., De Luca, F., Lombardo, V., De Santi, P., Banin, A., Franzese, L., Gargantini, E., Sampellegrini, R., Lorini, G., D’Annunzio, L., Lucentini, G., Marietti, A., Marsciani, M., Martinucci, C., Monciotti, A., Ogana, P., Picco, F., Prisco, Iafusco, Dario, Scattoni, M, L., Spallino, R., Vanini, L., Stocchero, M., Vanelli, G., Vhiari, and A., Visentin

Published
1997

11. Children with incidental hyperglycemia (Multicentre Italian Study)

Author

R. Lorini, L. Vitali, L. Cavallo, F. Cerutti, F. Cardella, G. Multari, A. Crinò, M. Cotellessa, P. Picco, G. Cerasoli, E. Bartolotta, L. Pinelli, L. Calisti, C. Monciotti, G. Marietti, P. Sacchini, A. Franzese, M. Pocecco, M. Vanelli, T. Arrigo, M. Martinucci, F. Meschi, MT Fonte, V. Cherubini, F. Chiarelli, F. Dammacco, F. Cadario, P. Banin, IAFUSCO, Dario, R., Lorini, L., Vitali, L., Cavallo, F., Cerutti, F., Cardella, G., Multari, A., Crinò, M., Cotellessa, P., Picco, G., Cerasoli, E., Bartolotta, L., Pinelli, L., Calisti, Iafusco, Dario, C., Monciotti, G., Marietti, P., Sacchini, A., Franzese, M., Pocecco, M., Vanelli, T., Arrigo, M., Martinucci, F., Meschi, Mt, Fonte, V., Cherubini, F., Chiarelli, F., Dammacco, F., Cadario, and P., Banin

Published
1997

12. Bambini con iperglicemia occasionale (studio multicentrico)

Author

I. Vitali, A. Alibrandi, R. Lorini, L. Cavallo, F. Cerutti, F. Cardella, N. Sulli, G. Multari, A. Crinò, M. Pelegrino, M. Cotellessa, P. Picco, G. Cerasoli, L. Guazzarotti, L. Pinelli, L. Calisti, F. Prisco, C. Monciotti, G. Marietti, P. Sacchini, A. Franzese, M. Pocecco, G. Chiari, M. Vanelli, F. Lombardo, A. Fasulo, M. Martinucci, F. Meschi, M. T. Fonte, V. Cherubini, F. Chiarelli, F. Dammacco, F. Cadario, P. Banin, IAFUSCO, Dario, I., Vitali, A., Alibrandi, R., Lorini, L., Cavallo, F., Cerutti, F., Cardella, N., Sulli, G., Multari, A., Crinò, M., Pelegrino, M., Cotellessa, P., Picco, G., Cerasoli, L., Guazzarotti, L., Pinelli, L., Calisti, Iafusco, Dario, F., Prisco, C., Monciotti, G., Marietti, P., Sacchini, A., Franzese, M., Pocecco, G., Chiari, M., Vanelli, F., Lombardo, A., Fasulo, M., Martinucci, F., Meschi, M. T., Fonte, V., Cherubini, F., Chiarelli, F., Dammacco, F., Cadario, and P., Banin

Published
1997

13. Children with incidental hyperglycemia: A Multicenter Italian Study

Author

L. Vitali, A. Alibrandi, R. Lorini, L. Cavallo, F. Cerutti, F. Cardella, N. Sulli, G. Multari, A. Crinò, M. Pelegrino, M. Cotellessa, P. Picco, G. Cerasoli, L. Guazzarotti, L. Pinelli, L. Calisti, F. Prisco, C. Monciotti, G. Marietti, P. Sacchini, A. Franzese, M. Pocecco, G. Chiari, M. Vanelli, F. Lombardo, A. Fasulo, M. Martinucci, F. Meschi, MT Fonte, V. Cherubini, F. Chiarelli, F. Dammacco, F. Cadario, P. Banin, IAFUSCO, Dario, L., Vitali, A., Alibrandi, R., Lorini, L., Cavallo, F., Cerutti, F., Cardella, N., Sulli, G., Multari, A., Crinò, M., Pelegrino, M., Cotellessa, P., Picco, G., Cerasoli, L., Guazzarotti, L., Pinelli, L., Calisti, Iafusco, Dario, F., Prisco, C., Monciotti, G., Marietti, P., Sacchini, A., Franzese, M., Pocecco, G., Chiari, M., Vanelli, F., Lombardo, A., Fasulo, M., Martinucci, F., Meschi, Mt, Fonte, V., Cherubini, F., Chiarelli, F., Dammacco, F., Cadario, and P., Banin

Published
1997

14. Caratteristiche epidemiologiche e cliniche del diabete mellito insulino-dipendente in bambini italiani di età inferiore a tre anni Epidemiological and clinical characteristics of type I insulin dependent diabetes mellitus in Italian children under 3 years old

Author

F. CERUTTI, F. CHIARELLI, E. CACCIARI, S. SALARDI, V. CHERUBINI, E. BARTOLOTTA, G. CHIUMELLO, F. MESCHI, M. COTELLESSA M. MAZZELLA, F. DAMMACCO, F. FREZZA, G. DE GIORGI, M. SPOSITO, A. FALORNI, F. FARAONI, M. POCECCO, S. MARINONI, C. SACCHETTI, G. AGOSTA, I. RABBONE, F. SEVERI, R. LORINI, G. STOPPOLONI, S. TUMINI, A. VERROTTI, M. VANELLI, S. CANTONI, IAFUSCO, Dario, F., Cerutti, F., Chiarelli, E., Cacciari, S., Salardi, V., Cherubini, E., Bartolotta, G., Chiumello, F., Meschi, M. COTELLESSA M., Mazzella, F., Dammacco, F., Frezza, G., DE GIORGI, M., Sposito, A., Falorni, F., Faraoni, M., Pocecco, S., Marinoni, C., Sacchetti, G., Agosta, I., Rabbone, F., Severi, R., Lorini, G., Stoppoloni, Iafusco, Dario, S., Tumini, A., Verrotti, M., Vanelli, and S., Cantoni

Published
1995

15. Coeliac Disease and insulin-dependent diabetes mellitus: A casual association? (Italian Multicentre Study)

Author

M. POCECCO, A. VENTURA, E. CACCIARI, S. SALARDI, L. CALISTI, G. SAGGESE, L. CAVALLO, F. TRENTADUE, F. CERUTTI, C. SACCHETTI, V. CHERUBINI, E. BARTOLOTTA, F. CHIARELLI, A. BLASETTI, F. DAMMACCO, A. TORELLI, S. MARINONI, G. TONINI, A. MARSCIANI, M. MARTINUCCI, A. MEDICI, A. MAZZELLA, M. COTELLESSA, F. MESCHI, G. BARERA, C. MONCIOTTI, G. MULTARI, G. ARGO, P. PICCO, G. STOPPOLONI, M. VANELLI, S. CANTONI, IAFUSCO, Dario, M., Pocecco, A., Ventura, E., Cacciari, S., Salardi, L., Calisti, G., Saggese, L., Cavallo, F., Trentadue, F., Cerutti, C., Sacchetti, V., Cherubini, E., Bartolotta, F., Chiarelli, A., Blasetti, F., Dammacco, A., Torelli, S., Marinoni, G., Tonini, A., Marsciani, M., Martinucci, A., Medici, A., Mazzella, M., Cotellessa, F., Meschi, G., Barera, C., Monciotti, G., Multari, G., Argo, P., Picco, G., Stoppoloni, Iafusco, Dario, M., Vanelli, and S., Cantoni

Published
1995

16. Type 1 diabetes in italian children under three years old Italian Collaborative Multicenter Study

Author

F. Cerutti, G. Agosia, G. Chiumello, F. Meschi, R. Lorini, M. Cotellessa, M. Pocecco, E. Cacciari, S. Salardi, M. Vanelli, F. Chiarelli, S. Tumini, V. Cherubini, A. Falorni, G. De Giorgi, G. Stoppoloni, F. D'Ammacco, IAFUSCO, Dario, F., Cerutti, G., Agosia, G., Chiumello, F., Meschi, R., Lorini, M., Cotellessa, M., Pocecco, E., Cacciari, S., Salardi, M., Vanelli, F., Chiarelli, S., Tumini, V., Cherubini, A., Falorni, G., De Giorgi, G., Stoppoloni, Iafusco, Dario, and F., D'Ammacco

Published
1992

17. A novel hepatocyte nuclear factor-1beta (MODY-5) gene mutation in an Italian family with renal dysfunctions and early-onset diabetes

Author

M. Cotellessa, Barella C, Renata Lorini, Gian Marco Ghiggeri, Carbone I, Francesco Perfumo, Gianluca Caridi, and Carlo Minetti

Subjects
Adult, Male, Endocrinology, Diabetes and Metabolism, MODY 5, Biology, Gene mutation, Kidney, Diabetes mellitus, Internal Medicine, medicine, Humans, Child, Early onset, Hepatocyte Nuclear Factor 1-beta, Genetics, medicine.disease, Kidney Transplantation, Pedigree, DNA-Binding Proteins, Diabetes Mellitus, Type 2, Italy, Hepatocyte Nuclear Factor 1-Beta, Kidney Failure, Chronic, Female, Kidney Diseases, Transcription Factors
Published
2002

18. [The adolescent with type 1 diabetes mellitus]

Author

R, Lorini, M, Cotellessa, L, Minicucci, and A, Giannattasio

Subjects
Adult, Male, Time Factors, Adolescent, Body Weight, Psychology, Adolescent, Puberty, Age Factors, Body Height, Diabetes Mellitus, Type 1, Sex Factors, Risk Factors, Diet, Diabetic, Humans, Insulin, Female, Longitudinal Studies, Follow-Up Studies
Published
2001

19. Corticosterone methyl oxidase type II deficiency: a cause of failure to thrive and recurrent dehydration in early infancy

Author

P Picco, M. DiRocco, Luigi Garibaldi, M Cotellessa, and C. Borrone

Subjects
Male, medicine.medical_specialty, Sodium, chemistry.chemical_element, Mixed Function Oxygenases, Elevated serum, Diagnosis, Differential, chemistry.chemical_compound, Recurrence, Internal medicine, Renin, medicine, Cytochrome P-450 CYP11B2, Humans, Dehydration, Corticosterone methyl oxidase, 18-Hydroxycorticosterone, Aldosterone, business.industry, Infant, medicine.disease, Early infancy, Hypoaldosteronism, Failure to Thrive, Endocrinology, chemistry, Pediatrics, Perinatology and Child Health, Failure to thrive, Potassium, Hyperkalemia, medicine.symptom, Hyponatremia, business
Abstract

Corticosterone methyl oxidase type II (CMO II) deficiency is an uncommon cause of salt-wasting in infancy. We describe a boy who presented with recurrent dehydration and severe failure to thrive in the first 3 months of life, associated with mild hyponatraemia (serum Na+ 127-132 mEq/l) and hyperkalaemia (serum K+ 5.3-5.9 mEq/l). The diagnosis was suggested by an elevated plasma renin activity (PRA): serum aldosterone ratio, and subsequently confirmed by an elevated serum 18-hydroxycorticosterone: aldosterone ratio. Treatment with 9 alpha-fluorohydroxycortisone normalized growth parameters and PRA levels. CMO II deficiency should be considered in infants with recurrent dehydration and failure to thrive, even when serum sodium and potassium levels are not strikingly abnormal.

Published
1992

21. N1303K mutation and diabetes mellitus in cystic fibrosis

Author

M. Cotellessa, Claudio Bruno, L. Romano, C Buzzanca, C. Romano, Laura Minicucci, M. Gandino, and Massimo Mazzella

Subjects
Adult, Male, Pathology, medicine.medical_specialty, Letter, Adolescent, Cystic Fibrosis, business.industry, Bioinformatics, medicine.disease, Cystic fibrosis, Diabetes mellitus, Mutation, Pediatrics, Perinatology and Child Health, Mutation (genetic algorithm), Diabetes Mellitus, Humans, Medicine, Female, business
Published
1996
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22. Autoimmune Thyroiditis In IDDM Patients

Author

M. Cotellessa, Vito Pistoia, Massimo Mazzella, and Paolo Picco

Subjects
Advanced and Specialized Nursing, Autoimmune thyroiditis, business.industry, Endocrinology, Diabetes and Metabolism, Diabetes mellitus, Immunology, Internal Medicine, medicine, medicine.disease, business
Published
1991
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23. Duplication of the short arm of chromosome 9. Analysis of five cases

Author

Francesco Pasquali, P. Alicata, Roberto Cerone, Orsetta Zuffardi, M. Cotellessa, G. Battaglino, L. Poloni, A. Ghidont, S. Motta, Giorgio Gimelli, Franca Bernardi, and Cristina Cuoco

Subjects
Adult, Chromosomes, Human, 6-12 and X, Genetics, Isochromosome, Infant, Trisomy, Chromosome 9, Chromosomal translocation, Karyotype, Biology, medicine.disease, Phenotype, Intellectual Disability, Karyotyping, Tetrasomy, Gene duplication, medicine, Humans, Abnormalities, Multiple, Female, Tetrasomy 9p, Child, Genetics (clinical)
Abstract

Five females with duplication of the short arm of one chromosome 9 are reported, one tetrasomic and four trisomic for 9p. The tetrasomy is due to an isochromosome 9p while the trisomies are due in one case to an intrachromosomal duplication present in lymphocytes but not in fibroblasts, two are secondary to translocations with chromosomes 22 and 13 respectively, and one is a mosaic with a cell line with an additional deleted chromosome 9 present in lymphocytes and fibroblasts. This analysis indicates that duplications 9p may result in impairment of ovarian function. The phenotypic differences between trisomy and tetrasomy 9p are discussed.

Published
1982
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24. Dihydropteridine reductase deficiency: Clinical, biochemical and therapeutic aspects

Author

S. Scalisi, M. Cotellessa, Corrado Romano, Ubaldo Caruso, M. C. Schiaffino, and Roberto Cerone

Subjects
medicine.medical_specialty, business.industry, Homovanillic acid, Biopterin, Metabolism, medicine.disease, Dihydropteridine Reductase, Dihydropteridine reductase deficiency, chemistry.chemical_compound, Hyperphenylalaninemia, Endocrinology, chemistry, Internal medicine, Genetics, medicine, Dihydrobiopterin synthetase, Neurotransmitter, business, Genetics (clinical)
Abstract

Inborn errors of biopterin metabolism are detected in 1–3% of patients with hyperphenylalaninaemia and appear to result from a deficiency of dihydropteridine reductase (DHPR, EC 1.6.99.7) (Kaufmann et al, 1975) or dihydrobiopterin synthetase (Bartholome etal., 1977) or GPT-cyclohydrolase (EC 3.5.4.16) (Nieder- wieser et al1982). In addition to hyperphenylalaninaemia, most infants and children with congenital defects of biopterin metabolism have decreased levels of neurotransmitter metabolites in CSF.

Published
1986
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26. Focusing on late effects in long-term survivors of childhood leukemia and lymphomas

Author

G. Stella, B. De Bernardi, G. F. Gargani, E. Casari, Comelli A, S. Gandus, M. L. Vitali, A. Pelizza, P. Cornaglia, Maria Luisa Garrè, M Cotellessa, Luisa M. Massimo, Riccardo Haupt, A. Ferrando, C. Querci, and B. Cesana

Subjects
Pediatrics, medicine.medical_specialty, Acute leukemia, Childhood leukemia, business.industry, medicine.medical_treatment, Cancer, Disease, medicine.disease, Late toxicity, Radiation therapy, Medicine, Endocrine system, business, Organ system
Abstract

Major advances have occurred in the treatment of children with cancer, leading to a high percentage of cure especially in Acute Lymphoblastic Leukemia (ALL), Hodgkin’s disease (HD) and non-Hodgkin’s Lymphomas (NHL). The remarkable improvement in the prognosis of childhood malignancies has been achieved with the use of combined modalities of treatment [1–4]. Consequently pediatric oncologists are now dealing with an increasing number of long-term survivors of these diseases and with their emerging treatment sequelae [5–9]. Late toxicity attributable to surgery (S) and radiotherapy (RT) is better known than that produced by chemotherpay (CT) or multimodal treatment [10, 11]. The frequency of long-term consequences of antineoplastic drug treatment in the pediatric age group is unknown. In addition there is little information regarding the relationships between their severity and the dose, schedule and duration of therapy [12]. Appropriate investigation of possible late sequelae must include a detailed evaluation of a number of organ systems including the cardiopulmonary, endocrine, hematopoetic, immune, musculoskeletal and central nervous systems [13].

Published
1987
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29. [Description of a case: Beckwith-Wiedemann syndrome]

Author

S, Nieri, C, Prestandrea, J, Lombardi, M, Cotellessa, and F, Cottafava

Subjects
Blood Glucose, Male, Beckwith-Wiedemann Syndrome, Cryptorchidism, Humans, Insulin, Child, Hypoglycemia
Published
1988

38. Beta-cell autoantibodies and diabetes mellitus family history in cystic fibrosis

Author

M. Cotellessa, Maria Antonietta Avanzini, Renata Lorini, Giuseppe d'Annunzio, Laura Minicucci, Nicola Minuto, and Livia Pittaluga

Subjects
Adult, Male, musculoskeletal diseases, medicine.medical_specialty, Adolescent, Cystic Fibrosis, Endocrinology, Diabetes and Metabolism, medicine.disease_cause, Gastroenterology, Cystic fibrosis, Autoimmunity, Pathogenesis, Islets of Langerhans, Endocrinology, Diabetes mellitus, Internal medicine, medicine, Humans, Family history, Child, Autoantibodies, business.industry, Autoantibody, Infant, Type 2 Diabetes Mellitus, Middle Aged, medicine.disease, Pedigree, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Case-Control Studies, Child, Preschool, Pediatrics, Perinatology and Child Health, Immunology, Female, Beta cell, business
Abstract

Objective: To verify whether autoimmunity against beta-cells and family history of type 1 and/or type 2 diabetes mellitus (DM) play a role in the pathogenesis of cystic fibrosis (CF)-related diabetes mellitus (CFRD). Patients and Methods: The prevalence of beta-cell autoantibodies (GADA and IA-2A) was investigated in a group of patients with CF compared with patients with type 1 DM (DM1) and controls. Family history of DM1 and/or DM2 was investigated among patients with CF. Results: Frequency of beta-cell autoantibodies was significantly lower (p = 0.0001) in patients with CF with CFRD (IA-2A: 0%; GADA 12.5%) than in patients with DM1 (64.1% vs 52.8%, respectively) and it did not differ from the frequency in patients with CF without CFRD. Prevalence of family history for DM1 or DM2 was not significantly higher in CF patients with CFRD than in CF patients without CFRD. Conclusions: The investigated factors did not show correlation with the pathogenesis of CFRD.

39. Geographical variation and rising trend of type 1 diabetes in Italy

Author

Cherubini V, Carle F, Gesuita R, Bruno G, Cotellessa M, Devoti G, Falorni A, Martinucci ME, Pinelli A, Prisco F, Sondini M, Visalli N, RIDI Study Group (P Barbieri, L Carpinelli, A Casu, F Cerutti, GV Coppa, G D'Annunzio, G De Giorgi, M Di Meio, P Frongia, A Gentili, Iafusco D, A Iannilli, R Lorini, G Marietti, AM Marinaro, M Mazzella, A Medici, F Merletti, G Pagano, ML Picchio, P Pozzilli, F Santeusanio, MT Tenconi, S Toni. ), F. Carle, R. Gesuita, G. Bruno, M. Cotellessa, G. Devoti, A. Falorni, M. E. Martinucci, A. Pinelli, F. Prisco, M. Songini, N. Visalli, RIDI Study Group, Barbieri, L Carpinelli, A Casu, F Cerutti, GV Coppa, G D' Annunzio, G De Giorgi, M Di Meio, P Frongia, A Gentili, D Iafusco, A Iannilli, R Lorini, G Marietti, AM Marinaro, M Mazzella, A Medici, F Merletti, G Pagano, ML Picchio, P Pozzilli, F Santeusanio, MT Tenconi, S Toni., Cherubini, V, Carle, F, Gesuita, R, Bruno, G, Cotellessa, M, Devoti, G, Falorni, A, Martinucci, Me, Pinelli, A, Prisco, F, Sondini, M, Visalli, N, RIDI Study Group (P, Barbieri, L, Carpinelli, A, Casu, F, Cerutti, Gv, Coppa, G, D'Annunzio, G De, Giorgi, M Di, Meio, P, Frongia, A, Gentili, Iafusco, D, A, Iannilli, R, Lorini, G, Marietti, Am, Marinaro, M, Mazzella, A, Medici, F, Merletti, G, Pagano, Ml, Picchio, P, Pozzilli, F, Santeusanio, Mt, Tenconi, and S, Toni. ).

Published
2002

40. Permanent diabetes mellitus in the first year of life

Author

Iafusco, D, Stazi, Ma, Cotichini, R, Cotellessa, M, Martinucci, Me, Mazzella, M, Cherubini, V, Barbetti, F, Martinetti, M, Cerutti, Franco, Prisco, F, Early Onset Diabetes Study Group of the Italian Society of Paediatric Endocrinology, Diabetology, Iafusco, Dario, M. A., Stazi, R., Cotichini, M., Cotellessa, M. E., Martinucci, M., Mazzella, V., Cherubini, F., Barbetti, M., Martinetti, F., Cerutti, and F., PRISCO AND THE EARLY ONSET DIABETES STUDY GROUP OF THE ITALIAN SOCIETY OF PAEDIATRIC ENDOCRINOLOGY AND DIABETOLOGY

Subjects
Male, medicine.medical_specialty, non-autoimmune diabetes mellitus, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Birth weight, Population, Gestational Age, Permanent neonatal diabetes, Type I diabetes, HLA protective heterodimers, autoimmune enteropathy, Settore MED/13 - Endocrinologia, Cohort Studies, Islets of Langerhans, Risk Factors, Internal medicine, Diabetes mellitus, Internal Medicine, Medicine, Birth Weight, Humans, Insulin, Age of Onset, education, Autoantibodies, Autoimmune disease, education.field_of_study, business.industry, Infant, Newborn, Infant, Permanent neonatal diabetes mellitus, Infant, Low Birth Weight, medicine.disease, Diabetes Mellitus, Type 1, Italy, Cohort, Immunology, Female, Seasons, Age of onset, business
Abstract

The pathogenesis of permanent diabetes mellitus diagnosed early in life is heterogeneous and, in most cases, not known. We aimed at identifying markers differentiating between non-autoimmune and autoimmune diabetes.The clinical, genetic and epidemiological features of 111 diabetic patients (62 males) who received insulin within 12 months of life were studied.The epidemic curve by age of diabetes onset revealed two subsets of patients at a cutoff of 180 days. In the group with diabetes onset before 180 days ("early onset" permanent diabetes) the analysis of HLA susceptibility heterodimers (available for 21 individuals) showed that 76% had a "protective" HLA genotype for Type I (insulin-dependent) diabetes mellitus as compared to 11.9% (5/42) of the later onset group. Accordingly, "early onset" children were less likely to have autoimmunity markers (4 out of 26 tested) than children with onset after 180 days (13 out 20 tested) (15.4% vs. 65.0%, p0.01). Of note, 19 out of 20 (or the 95%) patients who were born on the island of Sardinia, an Italian region where the incidence of Type I diabetes is six times higher than continental Italy (33/100,000/year vs 5/100,000/year), were included in the later onset group (180 days). Small-for-date birthweight, a possible sign of reduced foetal insulin secretion, was more common in the "early onset" group (OR=9.9, 95%-CI 2.6-38.6).These results, obtained in the largest population-based cohort of diabetic infants hitherto reported, suggest that "early onset" permanent diabetes cases differ from later onset cases and that most of them do not have an autoimmune pathogenesis.

Published
2001

41. Normal values of First-Phase Insulin Response to intravenous glucose in healthy italian children and adolescents

Author

Lorini, R., Vanelli, M., Arrigo, T., Banin, P., Calisti, L., Cardella, F., Gallo, F., Cerutti, F., Cherubini, V., Chiarelli, F., Cotellessa, M., Crinò, A., Falorni, A., Fonte, M. T., Marietti, G., Marsciani, A., Martinucci, M., Meschi, F., Picco, P., Pocecco, M., Dario Iafusco, Vitali, L., R., Lorini, M., Vanelli, T., Arrigo, P., Banin, L., Calisti, F., Cardella, F., Gallo, F., Cerutti, V., Cherubini, F., Chiarelli, M., Cotellessa, A., Crinò, A., Falorni, M. T., Fonte, G., Marietti, A., Marsciani, M., Martinucci, F., Meschi, P., Picco, M., Pocecco, Iafusco, Dario, and L., Vitali

Published
1996

42. Folic acid, vitamin B12, and homocysteine levels during fasting and after methionine load in patients with Type 1 diabetes mellitus.

Author

Giannattasio A, Calevo MG, Minniti G, Gianotti D, Cotellessa M, Napoli F, Lorini R, and d'Annunzio G

Subjects
Adolescent, Adult, Aging physiology, Blood Glucose metabolism, Case-Control Studies, Child, Female, Humans, Male, Sex Characteristics, Young Adult, Diabetes Mellitus, Type 1 blood, Fasting metabolism, Folic Acid blood, Homocysteine blood, Methionine, Vitamin B 12 blood
Abstract

Aims: To assess plasma concentrations of folic acid, vitamin B12, and total plasma homocysteine (tHCY) during fasting and after methionine load in young patients with Type 1 diabetes mellitus (T1DM)., Methods: We enrolled 41 young patients with T1DM without any sign of microvascular complications and 123 healthy controls in a 1:3 case-control study. Fasting and post-methionine load (PML) tHCY, folic acid, and vitamin B12 levels were measured in both groups. Data regarding chronological age, metabolic control (assessed by mean values of glycated hemoglobin in the last 12 months) and disease duration were also recorded., Results: Fasting and PML tHCY levels were significantly lower in patients than in controls: 7.3+/-2.7 micromol/l vs 8.3+/-2.5 micromol/l (p=0.01), and 16.7+/-5.8 micromol/l vs 17.3+/-4.3 micromol/l (p=0.01), respectively. No correlation was found between fasting and PML tHCY levels and chronological age, disease duration, metabolic control, and insulin requirement. Patients had significantly higher vitamin B12 levels compared to controls: 767+/-318 pg/ml vs 628+/-236 pg/ml (p=0.003), while folic acid turned out to be lower in patients than in controls: 5.3+/-1.9 nmol/l vs 7.5+/-2.6 nmol/l (p<0.0001)., Conclusions: Adolescents and young adults with T1DM without microvascular complications showed lower tHCY both during fasting and after methionine load. Lower folate concentrations in these patients might benefit from food fortification.

Published
2010
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43. Breastfeeding in Northern Italy.

Author

Santini P, Calevo MG, Caviglia MR, Asprea T, Bonacci W, Serra G, Cotellessa M, Revello G, Corciulo M, Boscarini A, Malvasio S, Renda R, Schiavetti P, Ivaldi M, and Corona MF

Subjects
Adolescent, Adult, Birthing Centers, Breast Feeding epidemiology, Educational Status, Female, Humans, Infant, Infant, Newborn, Italy epidemiology, Maternal Age, Parity, Pregnancy, Prospective Studies, Surveys and Questionnaires, Time Factors, Breast Feeding statistics & numerical data
Abstract

Aim: To describe the duration and type, as classified by World Health Organization (WHO) criteria, of breastfeeding in Ligurian newborns up to 1 year of age, and to identify possible related factors., Methods: A prospective, observational study on a cohort of 757 women recruited in 10 hospitals in Northern Italy. Women were followed up by means of a questionnaire at discharge and by telephone interviews in the 4th, 12th, 24th and 48th weeks postpartum using the 'recall period' method., Results: At discharge, 97.3% of mothers had started breastfeeding; regional breastfeeding rates at the 4th, 12th, 24th and 48th weeks were respectively 84.4%, 71.2%, 54.4% and 26.3%. Socio-demographic factors did not significantly influence these percentages. Median duration of breastfeeding was 6.5 months. No statistically significant differences were observed in duration of breastfeeding between women who started exclusive breastfeeding (EBF) and those who did predominant breastfeeding (PBF), while the difference was statistically significant when comparing complementary breastfeeding (CBF) with EBF and with PBF., Conclusions: Our study is the first regional experience in the Liguria region and represents a starting point for the diffusion of the culture of breastfeeding. Our results are satisfactory with regards to the overall duration of breastfeeding until the first year of life (26.3%), while duration of EBF (9.5% at the 24th week) is still unsatisfactory according to WHO objectives that include EBF for all children up to the sixth month of life.

Published
2008
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44. The IGF system in a case of Costello syndrome.

Author

Barreca A, Cotellessa M, Boschetti M, Giannattasio A, Cresta L, Schiaffino C, and Lorini R

Subjects
Carrier Proteins blood, Female, Glycoproteins blood, Humans, Hypoglycemia, Infant, Insulin-Like Growth Factor Binding Protein 2 blood, Insulin-Like Growth Factor Binding Protein 3 blood, Insulin-Like Growth Factor Binding Protein 6 blood, Insulin-Like Growth Factor I analysis, Insulin-Like Growth Factor II analysis, Intellectual Disability blood, Intellectual Disability complications, Keratoderma, Palmoplantar blood, Keratoderma, Palmoplantar complications, Syndrome, Craniofacial Abnormalities blood, Craniofacial Abnormalities complications, Growth Disorders blood, Growth Disorders complications, Hyperpigmentation blood, Hyperpigmentation complications, Somatomedins analysis
Abstract

Costello syndrome is characterized by facial dysmorphia, hyperpigmented skin, palmar and plantar hyperkeratosis, curly hair, perioral and nasal papillomata (more rarely localized anally and on vocal cords), short stature, mental retardation and sociable personality. Although growth retardation is typical of Costello syndrome, its cause is not defined. We report on a 10-yr-old Caucasian girl affected by Costello syndrome with fasting hypoglycemia and short stature, associated low circulating levels of acid-labile subunit (ALS), relatively low levels of IGF-I and IGFBP-3, and normal IGF-II, mostly circulating in a binary complex with IGFBP-2 and -6 instead of in a 150 kDa ternary complex. The reduced ALS concentration and the consequent impaired formation of the circulating 150 kDa ternary complex can induce an accelerated clearance rate of IGF peptides and of IGFBP-3, contributing to the decreased IGF-I growth promoting activity in our patient. Moreover, the presence of IGF-II in the binary complex, which has been postulated to increase the insulin-like effects of these peptides, can explain, at least in part, the patient's asymptomatic fasting hypoglycemia.

Published
2006
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45. Anti-CD38 autoimmunity in children with newly diagnosed type 1 diabetes mellitus.

Author

Pupilli C, Antonelli A, Iughetti L, D'Annunzio G, Cotellessa M, Vanelli M, Okamoto H, Lorini R, and Ferrannini E

Subjects
Autoantibodies blood, Child, Child, Preschool, Female, Humans, Male, ADP-ribosyl Cyclase 1 immunology, Autoimmunity, Diabetes Mellitus, Type 1 immunology
Abstract

Aims: To test for anti-CD38 autoimmunity in children with newly-diagnosed type 1 diabetes mellitus (DM1)., Methods: Serum anti-CD38 autoantibodies were detected by Western blot in 270 children (130 girls, 140 boys, mean age 8 +/- 4 years) with newly-diagnosed DM1 and 179 gender- and age-matched non-diabetic children. In 126 diabetic children, another blood sample was obtained 15 +/- 4 months after the diagnosis., Results: Anti-CD38 autoantibody titers at least 3 SD above the mean value for the control group were found in 4.4% of children with DM1 vs 0.6% of controls (chi2 = 5.8, p <0.016). No statistical differences were observed between anti-CD38 positive and negative patients in terms of phenotype. At follow-up, of six diabetic children who were positive for anti-CD38 antibodies, two were new cases. A positive correlation was found between the antibody titer of diabetic sera at diagnosis and follow up (r = 0.46, p <0.0001)., Conclusion: An autoimmune reaction against CD38, a protein expressed in human islets, is associated with newly-diagnosed DM1. In children with DM1, CD38 autoimmunity increases with time and persists.

Published
2005
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46. Beta-cell autoantibodies and diabetes mellitus family history in cystic fibrosis.

Author

Minicucci L, Cotellessa M, Pittaluga L, Minuto N, d'Annunzio G, Avanzini MA, and Lorini R

Subjects
Adolescent, Adult, Case-Control Studies, Child, Child, Preschool, Cystic Fibrosis etiology, Female, Humans, Infant, Male, Middle Aged, Pedigree, Autoantibodies, Cystic Fibrosis genetics, Cystic Fibrosis physiopathology, Diabetes Mellitus, Type 1 complications, Diabetes Mellitus, Type 2 complications, Islets of Langerhans immunology
Abstract

Objective: To verify whether autoimmunity against beta-cells and family history of type 1 and/or type 2 diabetes mellitus (DM) play a role in the pathogenesis of cystic fibrosis (CF)-related diabetes mellitus (CFRD)., Patients and Methods: The prevalence of beta-cell autoantibodies (GADA and IA-2A) was investigated in a group of patients with CF compared with patients with type 1 DM (DM1) and controls. Family history of DM1 and/or DM2 was investigated among patients with CF., Results: Frequency of beta-cell autoantibodies was significantly lower (p = 0.0001) in patients with CF with CFRD (IA-2A: 0%; GADA 12.5%) than in patients with DM1 (64.1% vs 52.8%, respectively) and it did not differ from the frequency in patients with CF without CFRD. Prevalence of family history for DM1 or DM2 was not significantly higher in CF patients with CFRD than in CF patients without CFRD., Conclusions: The investigated factors did not show correlation with the pathogenesis of CFRD.

Published
2005
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47. Diabetes mellitus after kidney transplantation in pediatric recipients.

Author

Cotellessa M, Pastorino N, Cresta L, Minicucci L, Basile G, Perfumo F, Lorini R, and Ginevri F

Subjects
Adult, Child, Diabetes Mellitus diagnosis, Female, Glucose Tolerance Test, Humans, Male, Retrospective Studies, Diabetes Mellitus etiology, Kidney Transplantation adverse effects, Postoperative Complications etiology
Published
2003
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48. High incidence of childhood type 1 diabetes in Liguria, Italy, from 1989 to 1998.

Author

Cotellessa M, Barbieri P, Mazzella M, Bonassi S, Minicucci L, and Lorini R

Subjects
Adolescent, Age Distribution, Child, Child, Preschool, Female, Geography, Humans, Infant, Italy epidemiology, Male, Sex Characteristics, Time Factors, Diabetes Mellitus, Type 1 epidemiology
Abstract

Objective: Assessing updated incidence of type 1 diabetes in 0- to 14-year-old children in Liguria, a Northwest region of Italy., Research Design and Methods: Incident cases were recorded prospectively from 1989 to 1998. Incidence rates (IRs) were standardized to the 1999 world population using the direct method. The independent effect of sex, age, residence, and calendar year was estimated with Poisson regression model. The degree of ascertainment was calculated in accordance to capture/recapture method., Results: During 10 full calendar years, 219 new cases of type 1 diabetes in children were diagnosed in Liguria. The standardized IR over the 10-year period was 12.56 cases per 100,000 per year (95% CI 11.0-14.3). The sex-specific IR among men and women was 14.15 and 10.88, respectively. The age-specific IR was higher in the 10- to 14-year-old age-group (15.01/100,000) than in 0- to 4-year-old age-group (9.01/100,000) and in the 5- to 9-year-old age-group (13.03/100,000)., Conclusions: The IR of type 1 diabetes in Liguria is among the highest in Southern Europe and approaches IRs of Northern European countries. In particular it is much higher than those reported in the surrounding Italian regions except for Sardinia. Therefore, the geographical distribution of type 1 diabetes does not seem to reflect the simple North-South gradient reported in several previous works.

Published
2003
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49. Permanent diabetes mellitus in the first year of life.

Author

Iafusco D, Stazi MA, Cotichini R, Cotellessa M, Martinucci ME, Mazzella M, Cherubini V, Barbetti F, Martinetti M, Cerutti F, and Prisco F

Subjects
Autoantibodies blood, Birth Weight, Cohort Studies, Diabetes Mellitus, Type 1 drug therapy, Diabetes Mellitus, Type 1 immunology, Female, Gestational Age, Humans, Infant, Infant, Low Birth Weight, Infant, Newborn, Islets of Langerhans immunology, Italy epidemiology, Male, Risk Factors, Seasons, Age of Onset, Diabetes Mellitus, Type 1 epidemiology, Insulin therapeutic use
Abstract

Aims/hypothesis: The pathogenesis of permanent diabetes mellitus diagnosed early in life is heterogeneous and, in most cases, not known. We aimed at identifying markers differentiating between non-autoimmune and autoimmune diabetes., Methods: The clinical, genetic and epidemiological features of 111 diabetic patients (62 males) who received insulin within 12 months of life were studied., Results: The epidemic curve by age of diabetes onset revealed two subsets of patients at a cutoff of 180 days. In the group with diabetes onset before 180 days ("early onset" permanent diabetes) the analysis of HLA susceptibility heterodimers (available for 21 individuals) showed that 76% had a "protective" HLA genotype for Type I (insulin-dependent) diabetes mellitus as compared to 11.9% (5/42) of the later onset group. Accordingly, "early onset" children were less likely to have autoimmunity markers (4 out of 26 tested) than children with onset after 180 days (13 out 20 tested) (15.4% vs. 65.0%, p<0.01). Of note, 19 out of 20 (or the 95%) patients who were born on the island of Sardinia, an Italian region where the incidence of Type I diabetes is six times higher than continental Italy (33/100,000/year vs 5/100,000/year), were included in the later onset group (>180 days). Small-for-date birthweight, a possible sign of reduced foetal insulin secretion, was more common in the "early onset" group (OR=9.9, 95%-CI 2.6-38.6)., Conclusion/interpretation: These results, obtained in the largest population-based cohort of diabetic infants hitherto reported, suggest that "early onset" permanent diabetes cases differ from later onset cases and that most of them do not have an autoimmune pathogenesis.

Published
2002
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50. A novel hepatocyte nuclear factor-1beta (MODY-5) gene mutation in an Italian family with renal dysfunctions and early-onset diabetes.

Author

Carbone I, Cotellessa M, Barella C, Minetti C, Ghiggeri GM, Caridi G, Perfumo F, and Lorini R

Subjects
Adult, Child, Female, Hepatocyte Nuclear Factor 1-beta, Humans, Italy, Kidney Diseases surgery, Kidney Failure, Chronic genetics, Kidney Transplantation, Male, Pedigree, DNA-Binding Proteins genetics, Diabetes Mellitus, Type 2 genetics, Kidney abnormalities, Kidney Diseases genetics, Transcription Factors genetics
Published
2002
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