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1. Synthesis and Characterization of New Amino Acid-Schiff Bases and Studies their Effects on the Activity of ACP, PAP and NPA Enzymes (In Vitro)

Author

Zahraa Salim M. Al-Garawi, Ivan Hameed R. Tomi, and Ali Hussein R. Al-Daraji

Subjects
Chemistry, QD1-999
Abstract

In this study, two new Schiff base compounds derived from the condensation reaction of L-glycine and L-tryptophan with 4-methylbenzal-dehyde have been synthesized. The Schiff base compounds were characterized by FT-IR, UV and 1H NMR spectroscopy. Their effects on the activity of total (ACP), prostatic (PAP) and non prostatic (NPA) acid phosphatase enzymes were studied. The Schiff base derived from L-glycine (A) demonstrated inhibition effect on the ACP and NPA activities and activation effect on PAP activity. The Schiff base derived from L-tryptophan (B) demonstrated semi fixed inhibition effects on the ACP and NPA activities at high concentrations (5.5×10-2, 5.5×10-3 and 5.5×10-4 M) and activator effect at low concentration (5.5×10-5 M) while it was exhibits as activator on PAP activity.

Published
2012
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2. Multiwavelength Photo-Magnetic Imaging Algorithm Improved For Direct Chromophore Concentration Recovery Using Spectral Constraints

Author

Hakan Erkol, M. Al-Garawi, Gultekin Gulsen, Alex Luk, and Farouk Nouizi

Subjects
Optics, Phantoms, Imaging, business.industry, Computer science, Image Processing, Computer-Assisted, Electrical and Electronic Engineering, business, Magnetic Resonance Imaging, Engineering (miscellaneous), Algorithms, Atomic and Molecular Physics, and Optics
Abstract

Multiwavelength photo-magnetic imaging (PMI) is a novel combination of diffuse optics and magnetic resonance imaging, to the best of our knowledge, that yields tissue chromophore concentration maps with high resolution and quantitative accuracy. Here, we present the first experimental results, to the best of our knowledge, obtained using a spectrally constrained PMI image reconstruction method, where chromophore concentration maps are directly recovered, unlike the conventional two-step approach that requires an intermediate step of reconstructing wavelength-dependent absorption coefficient maps. The imposition of the prior spectral information into the PMI inverse problem improves the reconstructed image quality and allows recovery of highly quantitative concentration maps, which are crucial for effective cancer detection and characterization. The obtained results demonstrate the higher performance of the direct reconstruction method. Indeed, the reconstructed concentration maps are not only of higher quality but also obtained approximately 2 times faster than the conventional method.

Published
2021

3. Multi-Wavelength Photo-Magnetic Imaging System for Photothermal Therapy Guidance

Author

Gultekin Gulsen, Seunghoon Ha, Mehmet Burcin Unlu, Alex Luk, Hakan Erkol, M. Al-Garawi, and Farouk Nouizi

Subjects
Materials science, Hot Temperature, Absorption spectroscopy, genetic structures, Photothermal Therapy, Dermatology, Thermometry, 01 natural sciences, Imaging phantom, Article, law.invention, 010309 optics, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Optics, law, 0103 physical sciences, Laser power scaling, Absorption (electromagnetic radiation), business.industry, Phantoms, Imaging, Lasers, Photothermal therapy, Laser, Wavelength, Attenuation coefficient, Surgery, sense organs, business
Abstract

Background and objectives In photothermal therapy, cancerous tissue is treated by the heat generated from absorbed light energy. For effective photothermal therapy, the parameters affecting the induced temperature should be determined before the treatment by modeling the increase in temperature via numerical simulations. However, accurate simulations can only be achieved when utilizing the accurate optical, thermal, and physiological properties of the treated tissue. Here, we propose a multi-wavelength photo-magnetic imaging (PMI) technique that provides quantitative and spatially resolved tissue optical absorption maps at any wavelength within the near-infrared (NIR) window to assist accurate photothermal therapy planning. Study design/materials and methods The study was conducted using our recently developed multi-wavelength PMI system, which operates at four laser wavelengths (760, 808, 860, and 980 nm). An agar tissue-simulating phantom containing water, lipid, and ink was illuminated using these wavelengths, and the slight internal laser-induced temperature rise was measured using magnetic resonance thermometry (MRT). The phantom optical absorption was recovered at the used wavelengths using our dedicated PMI image reconstruction algorithm. These absorption maps were then used to resolve the concentration of the tissue chromophores, and thus deduce its optical absorption spectrum in the NIR region based on the Beer-Lambert law. Results The optical absorption of the phantom was successfully recovered at the used four wavelengths with an average error of ~1.9%. The recovered absorption coefficient was then used to simulate temperature variations inside the phantom. A comparison between the modeled temperature maps and the MRT measured ones showed that these maps are in a good agreement with an average pseudo R2 statistic of 0.992. These absorption values were used to successfully recover the concentration of the used chromophores. Finally, these concentrations are used to accurately calculate the total absorption spectrum of the phantom in the NIR spectral window with an average error as low as ~2.3%. Conclusions Multi-wavelength PMI demonstrated a great ability to assess the distribution of tissue chromophores, thus providing its total absorption at any wavelength within the NIR spectral range. Therefore, applications of photothermal therapy applied at NIR wavelengths can benefit from the absorption spectrum recovered by PMI to determine important parameters such as laser power as well as the laser exposure time needed to attain a specific increase in temperature prior to treatment. Lasers Surg. Med. 00:00-00, 2020. © 2020 Wiley Periodicals LLC.

Published
2020

4. Reconstruction chromophore concentration directly by Photo-Magnetic Imaging: simulation study

Author

Alex Luk, Gultekin Gulsen, Farouk Nouizi, Burcin Unlu, Mohammed Almudhry, Hakan Erkol, and M. Al-Garawi

Subjects
Wavelength, Materials science, Magnetic imaging, Attenuation coefficient, Resonance, sense organs, Chromophore, Absorption (electromagnetic radiation), Molecular physics, Diffuse optical imaging
Abstract

Tomographically recovering chromophore concentrations usually requires the intermediate step of reconstructing absorption maps at different wavelengths first. Here, we present a method that allows to obtain these concentrations directly from measured magnetic resonance temperature maps.

Published
2020
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5. Experimental validation of a multiple wavelength Photo-Magnetic Imaging system

Author

Mohammed Almudhry, Burcin Unlu, Seunghoon Ha, Hakan Erkol, M. Al-Garawi, Alex Luk, Gultekin Gulsen, and Farouk Nouizi

Subjects
Materials science, business.industry, Computer Science::Information Retrieval, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, Computer Science::Computation and Language (Computational Linguistics and Natural Language and Speech Processing), Iterative reconstruction, Experimental validation, Quantitative accuracy, Diffuse optical imaging, Wavelength, Optics, Magnetic imaging, Imaging technique, business, Absorption (electromagnetic radiation)
Abstract

Photo-Magnetic Imaging (PMI) is a novel multimodality imaging technique that provides optical absorption maps with high-resolution and quantitative accuracy. Here, we present the preliminary experimental validation results obtained using our new multi-wavelength PMI system.

Published
2020
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6. CCD-based temperature modulated fluorescence tomography

Author

Tiffany C. Kwong, Farouk Nouizi, Uma Sampathkumaran, Hakan Erkol, M. Al-Garawi, Gultekin Gulsen, and Mehrnaz Mehrabi

Subjects
Materials science, business.industry, Scattering, medicine.medical_treatment, Iterative reconstruction, Fluorescence, Signal, High-intensity focused ultrasound, Optics, medicine, Medical imaging, Molecular imaging, business, Image resolution
Abstract

High scattering in biological tissues severely degrades the spatial resolution of optical fluorescence imaging in thick tissue. As one of the most sensitive in vivo molecular imaging modalities, Fluorescence Tomography plays an essential role in preclinical studies. To overcome the limitations of FT, we introduced a novel method termed, temperature modulated fluorescence tomography (TMFT). TMFT is based on two key elements: 1) temperature sensitive fluorescent agent (ThermoDots) and 2) high intensity focused ultrasound (HIFU). TMFT localizes the position of the fluorescent ThermoDots by scanning a HIFU beam across the tissue while monitoring the variation in the measured fluorescence signals. Actually, a binary mask is built by monitoring the sudden jumps in the fluorescence signal corresponding to the HIFU scan over a position containing ThermoDots. This binary map is used as functional a priori during the FT image reconstruction process. TMFT not only allowed us to resolve ThermoDots with high spatial resolution (~1.3 mm), deep in tissue (~ 60 mm) but with high quantitative accuracy as well (< 3% error). In this paper, we present the latest prototype of TMFT. Here, the fluorescence signals are acquired using a CCD camera, which increases the sensitivity of the system compared to the previous fiber-based system.

Published
2019
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7. High-resolution chromophore concentration recovery using multi-wavelength photo-magnetic imaging

Author

Seunghoon Ha, Mehmet Burcin Unlu, Gultekin Gulsen, Farouk Nouizi, Hakan Erkol, M. Al-Garawi, Mehrnaz Mehrabi, and Alex Luk

Subjects
Materials science, medicine.diagnostic_test, business.industry, Ranging, Magnetic resonance imaging, Laser, Imaging phantom, Diffuse optical imaging, law.invention, Wavelength, Optics, law, medicine, business, Absorption (electromagnetic radiation), Image resolution
Abstract

Although diffuse optical tomography (DOT) is able to obtain valuable functional information, its routine use in clinic is hampered by its poor spatial resolution and quantitative accuracy. Previously, our team introduced Photo-Magnetic Imaging (PMI) to overcome the limitation of DOT. PMI is a hybrid modality that synergistically utilizes optics and Magnetic Resonance Imaging (MRI). While illuminating the imaged medium by near-infrared laser, the induced internal temperature increase is measured using Magnetic Resonance Thermometry (MRT). Using these MRT maps, optical absorption maps at the laser's wavelength can be recovered using the dedicated PMI image reconstruction algorithm. In this paper, we present the result of the first validation simulation study of multi-wavelength PMI that utilizes five different laser wavelengths ranging between 760 and 980 nm. Using the high resolution wavelength specific absorption maps, PMI successfully recovered the concentration of three dyes, used as chromophore in the composition of our phantom, with high spatial resolution and quantitative accuracy. By providing functional information at high resolution, multi-wavelength PMI will be a valuable tool for monitoring tissue physiology, cancer detection and monitoring.

Published
2019
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8. Validation of a comprehensive analytical model for photothermal therapy planning in a layered medium with gold nanoparticles

Author

Farouk Nouizi, Gultekin Gulsen, S.Z. Yelken, Hakan Erkol, and M. Al-Garawi

Subjects
Fluid Flow and Transfer Processes, Diffusion equation, Materials science, Quantitative Biology::Tissues and Organs, Mechanical Engineering, Physics::Medical Physics, Conventional surgery, 02 engineering and technology, Photothermal therapy, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Laser, 01 natural sciences, Finite element method, 010305 fluids & plasmas, law.invention, Colloidal gold, law, 0103 physical sciences, 0210 nano-technology, Absorption (electromagnetic radiation), Reduction (mathematics), Biological system
Abstract

Photothermal therapy (PIT) is a minimally invasive alternative to conventional surgery and can provide faster recovery times as well as reduction in complication rates. Successfully targeting of gold nanoparticles to the tumor increases its light absorption leading to more important temperature rise in the tumor than surrounding tissue. Hence, it is possible to heat tumor with a minimal damage to the surrounding tissue only if the appropriate laser parameters are employed. In this study, our purpose is to develop a simulation tool capable of determining temperature rise and duration in the tissue for therapy planning. This simulation tool is based on a new analytical approach which models laser-induced temperature in a two-layered medium mimicking concentric tumor and its surrounding healthy tissue. First, the diffusion equation is used to model the light propagation in tissue and then a comprehensive solution is derived by obtaining a special Greens' function. Next, the Pennes' bioheat equation is analytically solved for a source term defined as the product of local optical absorption and the solution of the diffusion equation. Our approach is validated by comparing the spatiotemporal temperature distribution obtained by our method, finite element method, and experimental studies, respectively. The obtained results are in very good agreement with an average R-squared of 0.953. This analytical approach can provide a suitable and fast platform for modeling laser-induced temperature distribution for thermal therapy applications. (C) 2020 Elsevier Ltd. All rights reserved.

Published
2020
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9. Resolving tissue chromophore concentration at MRI resolution using multi-wavelength photo-magnetic imaging

Author

Farouk Nouizi, Mehmet Burcin Unlu, Seunghoon Ha, Alex Luk, Hakan Erkol, M. Al-Garawi, and Gultekin Gulsen

Subjects
0303 health sciences, Materials science, genetic structures, business.industry, Resolution (electron density), Chromophore, Laser, 01 natural sciences, Article, Atomic and Molecular Physics, and Optics, Imaging phantom, Diffuse optical imaging, law.invention, 010309 optics, 03 medical and health sciences, Wavelength, Optics, law, 0103 physical sciences, business, Absorption (electromagnetic radiation), Preclinical imaging, 030304 developmental biology, Biotechnology
Abstract

Photo-magnetic imaging (PMI) is an emerging optical imaging modality that showed great performance on providing absorption maps with high resolution and quantitative accuracy. As a multi-modality technology, PMI warms up the imaged object using a near infrared laser while temperature variation is measured using magnetic resonance imaging. By probing tissue at multiple wavelengths, concentration of the main tissue chromophores such as oxy-and deoxy-hemoglobin, lipid, and water are obtained then used to derive functional parameters such as total hemoglobin concentration and relative oxygen saturation. In this paper, we present a multi-wavelength PMI system that was custom-built to host five different laser wavelengths. After recovering the high-resolution absorption maps, a least-squared minimization process was used to resolve the different chromophore concentration. The performance of the system was experimentally tested on a phantom with two different dyes. Their concentrations were successfully assessed with high spatial resolution and average accuracy of nearly 80%. (C) 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

Published
2020
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10. A Comprehensive Analytical Based Computational Technique for Laser Induced Heat in a Gold Nano-particle Embedded Turbid Medium

Author

Alex Luk, Farouk Nouizi, Gultekin Gulsen, Mehmet Burcin Unlu, Mehrnaz Mehrabi, Hakan Erkol, and M. Al-Garawi

Subjects
Diffusion equation, Materials science, law, Attenuation coefficient, Physics::Optics, Function (mathematics), Laser power scaling, Absorption (electromagnetic radiation), Laser, Imaging phantom, Finite element method, Computational physics, law.invention
Abstract

In this study, we develop an analytical based simulation method to determine laser parameters such as laser power and its duration for laser induced thermal ablation. This method utilizes two important physical approaches to model i) the light propagation and ii) the change in temperature due to the laser absorption in turbid media. First, the photon density is obtained analytically from the solution of the diffusion equation by deriving a special Greens’ function. Next, the Pennes bio-heat equation is solved analytically for a source term consisting of the product of the photon density and the optical absorption coefficient. Our approach is validated with the results obtained by Finite Element Method (FEM) and experimental results acquired from the gold-nanoparticle embedded phantom.

Published
2018
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11. Multi-wavelengths Photo Magnetic Imaging

Author

Gultekin Gulsen, Farouk Nouizi, Hakan Erkol, M. Al-Garawi, Alex Luk, and Mehrnaz Mehrabi

Subjects
Materials science, business.industry, Resonance, Image processing, Laser, Diffuse optical imaging, law.invention, Wavelength, Optics, law, Magnetic imaging, Attenuation coefficient, business, Absorption (electromagnetic radiation)
Abstract

Photo-Magnetic Imaging (PMI) is a novel diffuse optical imaging technique that yields high resolution optical absorption images. It is based on the measurement of the temperature increase of a given medium after its illumination with a near-infrared laser using Magnetic Resonance Thermometry (MRT). In this paper, we present the first multi-wavelengths PMI system able to provide oxy- and deoxyhemoglobin concentration maps with high spatial and quantitative accuracy.

Published
2018
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12. Probing the Symmetry Term of the Nuclear Equation of State at High Baryonic Densities

Author

M. Trimarchi, A. Chbihi, Piotr Pawłowski, G. Lanzalone, Riccardo Introzzi, Roy Crawford Lemmon, S. Kupny, Yongjia Wang, Z. Matthews, F. Amorini, Marielle Chartier, M. Zoric, J. Brzychczyk, Chiara Guazzoni, F. Rizzo, N. Kurz, H. H. Wolter, Matthias Heil, M. Al-Garawi, D. M. Rossi, Zbigniew Sosin, P. Z. Wu, Maria Colonna, A. Budzanowski, Qingfeng Li, Yassid Ayyad, W. G. Lynch, Abdulrahman Alajlan, F. Porto, M. Mostazo, Sherry Yennello, Herbert A. Simon, P. Wigg, Giuseppe Verde, P. Cammarata, Lauren Heilborn, D. G. Sarantites, S. Al-Homaidhi, E. V. Pagano, S. Santoro, Mariano Vigilante, W. Reviol, A. Pagano, P. Guazzoni, S. Pirrone, L. Stuhl, T. Isobe, E. La Guidara, P. Lasko, K. Kezzar, J. Łukasik, L. Zetta, P. Russotto, L. Grassi, Michael Famiano, J. Benlliure, A. Wieloch, M. Boisjoli, I. Skwirczyńska, W. Trautmann, S. Gannon, Igor Gašparić, Jack Winkelbauer, Elio Rosato, A. Le Fèvre, Thomas Aumann, M. Kiš, P. Zambon, Z. Chajecki, Michele Papa, M. Adamczyk, Ivano Lombardo, M. B. Tsang, M. D. Cozma, A. Trifirò, Martin Veselsky, F. Riccio, Luis Acosta, Yvonne Leifels, E. De Filippo, K. Boretzky, L. W. May, Lucrezia Auditore, C. Caesar, G. Politi, M. Di Toro, B. Czech, Attila Krasznahorkay, G. Cardella, Paola Marini, Triestino Minniti, Zoran Basrak, Grand Accélérateur National d'Ions Lourds (GANIL), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Russotto, P., Acosta, L., Adamczyk, M., Al-Ajlan, A., Al-Garawi, M., Al-Homaidhi, S., Amorini, F., Auditore, L., Aumann, T., Ayyad, Y., Basrak, Z., Benlliure, J., Boisjoli, M., Boretzky, K., Brzychczyk, J., Budzanowski, A., Caesar, C., Cardella, G., Cammarata, P., Chajecki, Z., Chartier, M., Chbihi, A., Colonna, M., Cozma, M. D., Czech, B., De Filippo, E., Di Toro, M., Famiano, M., Gannon, S., Gašparić, I., Grassi, L., Guazzoni, C., Guazzoni, P., Heil, M., Heilborn, L., Introzzi, R., Isobe, T., Kezzar, K., Kiš, M., Krasznahorkay, A., Kupny, S., Kurz, N., La Guidara, E., Lanzalone, G., Lasko, P., Le Fèvre, A., Leifels, Y., Lemmon, R. C., Li, Q. F., Lombardo, I., Łukasik, J., Lynch, W. G., Marini, P., Matthews, Z., May, L., Minniti, T., Mostazo, M., Pagano, A., Pagano, E. V., Papa, M., Pawłowski, P., Pirrone, S., Politi, G., Porto, F., Reviol, W., Riccio, F., Rizzo, F., Rosato, E., Rossi, D., Santoro, S., Sarantites, D. G., Simon, H., Skwirczynska, I., Sosin, Z., Stuhl, L., Trautmann, W., Trifirò, A., Trimarchi, M., Tsang, M. B., Verde, G., Veselsky, M., Vigilante, M., Wang, Yongjia, Wieloch, A., Wigg, P., Winkelbauer, J., Wolter, H. H., Wu, P., Yennello, S., Zambon, P., Zetta, L., and Zoric, M.

Subjects
Physics, Linear density, History, [PHYS.NUCL]Physics [physics]/Nuclear Theory [nucl-th], 010308 nuclear & particles physics, Nuclear Theory, Nuclear equation of state, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 01 natural sciences, Charged particle, Symmetry (physics), Computer Science Applications, Education, Term (time), Nuclear physics, Baryon, Physics and Astronomy (all), symmetry energy, neutron flow, nuclear equation of state, heavy-ion scattering, relativistic quantum molecular dynamics, Darmstadt GSI FAIR, density dependence, transport theory, elliptic flow, 0.4 GeV/nucleon, Quantum electrodynamics, 0103 physical sciences, Neutron, 010306 general physics, Nucleon, Nuclear Experiment
Abstract

International audience; In the ASY-EOS experiment flows of neutrons and light charged particles were measured for (197)Au+(197)Au collisions at 400 MeV/nucleon, in order to investigate the strength of the symmetry term of the nuclear equation of state at supra-saturation densities. By comparing the experimental data with the UrQMD transport model predictions, we have extracted a new constraint in agreement with the moderately soft to linear density dependence obtained in the former analysis on FOPI-LAND data, but reducing the associated uncertainty by a factor ∼ 2.

Published
2017
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13. Results of the ASY-EOS experiment at GSI: The symmetry energy at suprasaturation density

Author

S. Al-Homaidhi, Abdulrahman Alajlan, A. Wieloch, F. Amorini, Angelo Pagano, Marielle Chartier, E. Rosato, Roy Crawford Lemmon, D. G. Sarantites, S. Kupny, Z. Chajecki, Martin Veselsky, Tadaaki Isobe, M. B. Tsang, F. Riccio, Z. Basrak, Triestino Minniti, A. Chbihi, G. Cardella, P. Zambon, Piotr Pawłowski, J. Benlliure, Giuseppe Verde, Michele Papa, M. Adamczyk, L. Stuhl, Marina Trimarchi, M.D. Cozma, J. Brzychczyk, A. Trifirò, E. De Filippo, C. Caesar, Z. Matthews, Maria Colonna, Lauren Heilborn, F. Rizzo, S. Santoro, N. Kurz, S. Pirrone, S. Gannon, H. H. Wolter, M. Kiš, Luis Acosta, P. Cammarata, Igor Gašparić, Jack Winkelbauer, P. Lasko, Michael Heil, E. La Guidara, Y. Leifels, A. Le Fèvre, A. Krasznahorkay, K. Boretzky, M. Di Toro, B. Czech, I. Lombardo, Thomas Aumann, P. Wigg, E. V. Pagano, M. Boisjoli, K. Kezzar, Paola Marini, W. Reviol, P. Guazzoni, Michael Famiano, I. Skwirczyńska, L. Zetta, P. Russotto, Sherry Yennello, F. Porto, M. Mostazo, W. G. Lynch, H. Simon, M. Zoric, Riccardo Introzzi, M. Al-Garawi, P. Z. Wu, Yassid Ayyad, J. Łukasik, L. Grassi, Chiara Guazzoni, A. Budzanowski, D. M. Rossi, Zbigniew Sosin, Qingfeng Li, Mariano Vigilante, W. Trautmann, G. Lanzalone, Yongjia Wang, L. W. May, Lucrezia Auditore, G. Politi, Grand Accélérateur National d'Ions Lourds (GANIL), Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Russotto, P., Gannon, S., Kupny, S., Lasko, P., Acosta, L., Adamczyk, M., Al-Ajlan, A., Al-Garawi, M., Al-Homaidhi, S., Amorini, F., Auditore, L., Aumann, T., Ayyad, Y., Basrak, Z., Benlliure, J., Boisjoli, M., Boretzky, K., Brzychczyk, J., Budzanowski, A., Caesar, C., Cardella, G., Cammarata, P., Chajecki, Z., Chartier, M., Chbihi, A., Colonna, M., Cozma, M. D., Czech, B., De Filippo, E., Di Toro, M., Famiano, M., Gašparić, I., Grassi, L., Guazzoni, C., Guazzoni, P., Heil, M., Heilborn, L., Introzzi, R., Isobe, T., Kezzar, K., Kiš, M., Krasznahorkay, A., Kurz, N., La Guidara, E., Lanzalone, G., Le Fèvre, A., Leifels, Y., Lemmon, R. C., Li, Q. F., Lombardo, I., Łukasik, J., Lynch, W. G., Marini, P., Matthews, Z., May, L., Minniti, T., Mostazo, M., Pagano, A., Pagano, E. V., Papa, M., Pawłowski, P., Pirrone, S., Politi, G., Porto, F., Reviol, W., Riccio, F., Rizzo, F., Rosato, E., Rossi, D., Santoro, S., Sarantites, D. G., Simon, H., Skwirczynska, I., Sosin, Z., Stuhl, L., Trautmann, W., Trifirò, A., Trimarchi, M., Tsang, M. B., Verde, G., Veselsky, M., Vigilante, M., Wang, Yongjia, Wieloch, A., Wigg, P., Winkelbauer, J., Wolter, H. H., Wu, P., Yennello, S., Zambon, P., Zetta, L., and Zoric, M.

Subjects
Physics, Nuclear and High Energy Physics, sezele, 010308 nuclear & particles physics, Elliptic flow, FOS: Physical sciences, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 01 natural sciences, Charged particle, Symmetry (physics), Nuclear physics, symmetry energy, neutron flow, nuclear equation of state, heavy-ion scattering, relativistic quantum molecular dynamics, Darmstadt GSI FAIR, density dependence, transport theory, elliptic flow, 0.4 GeV/nucleon, 0103 physical sciences, HEAVY-ION COLLISIONS, EQUATION-OF-STATE, MASS-RADIUS RELATION, COLLECTIVE FLOW, PION-PRODUCTION, NEUTRON, DEPENDENCE, FRAGMENTATION, SYSTEMATICS, EMISSION, Large Area Neutron Detector, Neutron, Nuclear Experiment (nucl-ex), Nuclear Experiment, 010306 general physics, Nucleon, Event (particle physics), Parametrization
Abstract

Directed and elliptic flows of neutrons and light charged particles were measured for the reaction 197Au+197Au at 400 MeV/nucleon incident energy within the ASY-EOS experimental campaign at the GSI laboratory. The detection system consisted of the Large Area Neutron Detector LAND, combined with parts of the CHIMERA multidetector, of the ALADIN Time-of-flight Wall, and of the Washington-University Microball detector. The latter three arrays were used for the event characterization and reaction-plane reconstruction. In addition, an array of triple telescopes, KRATTA, was used for complementary measurements of the isotopic composition and flows of light charged particles. From the comparison of the elliptic flow ratio of neutrons with respect to charged particles with UrQMD predictions, a value \gamma = 0.72 \pm 0.19 is obtained for the power-law coefficient describing the density dependence of the potential part in the parametrization of the symmetry energy. It represents a new and more stringent constraint for the regime of supra-saturation density and confirms, with a considerably smaller uncertainty, the moderately soft to linear density dependence deduced from the earlier FOPI-LAND data. The densities probed are shown to reach beyond twice saturation., Comment: 25 pages, 22 figures, accepted for publication in Physical Review C

Published
2016
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14. The symmetry energy at suprasaturation density and the ASY-EOS experiment at GSI

Author

S. Santoro, P. Lasko, Luis Acosta, D. G. Sarantites, S. Al-Homaidhi, K. Boretzky, Giuseppe Verde, F. Porto, S. Pirrone, Z. Chajecki, E. V. Pagano, D. M. Rossi, Zbigniew Sosin, Qingfeng Li, A. Wieloch, Sherry Yennello, F. Rizzo, L. Stuhl, M. B. Tsang, L. Zetta, Roy Crawford Lemmon, S. Kupny, Maria Colonna, M. Kiš, Martin Veselsky, P. Zambon, C. Caesar, F. Riccio, P. Cammarata, Yvonne Leifels, I. Skwirczyńska, J. Benlliure, Marina Trimarchi, Chiara Guazzoni, Mariano Vigilante, A. Trifirò, P. Russotto, Z. Basrak, A. Chbihi, L. W. May, W. Trautmann, M. Di Toro, Piotr Pawłowski, B. Czech, E. La Guidara, M.D. Cozma, W. Reviol, A. Pagano, P. Guazzoni, H. H. Wolter, Michael Famiano, J. Brzychczyk, E. De Filippo, M. Al-Garawi, G. Cardella, G. Lanzalone, Z. Matthews, Igor Gašparić, Jack Winkelbauer, W. G. Lynch, A. Budzanowski, N. Kurz, L. Grassi, M. Mostazo, A. Le Fèvre, Elio Rosato, Paola Marini, M. Zoric, Thomas Aumann, A. Krasznahorkay, Herbert A. Simon, Riccardo Introzzi, Yongjia Wang, P. Wigg, K. Kezzar, Abdulrahman Alajlan, J. Łukasik, P. Z. Wu, Yassid Ayyad, Triestino Minniti, Ivano Lombardo, Lucrezia Auditore, G. Politi, M. Boisjoli, F. Amorini, Marielle Chartier, Lauren Heilborn, Tadaaki Isobe, Matthias Heil, Michele Papa, M. Adamczyk, S. Gannon, Grand Accélérateur National d'Ions Lourds (GANIL), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), De Filippo, E., Russotto, P., Acosta, L., Adamczyk, M., Al-Ajlan, A., Al-Garawi, M., Al-Homaidhi, S., Amorini, F., Auditore, L., Aumann, T., Ayyad, Y., Basrak, Z., Benlliure, J., Boisjoli, M., Boretzky, K., Brzychczyk, J., Budzanowski, A., Caesar, C., Cardella, G., Cammarata, P., Chajecki, Z., Chartier, M., Chbihi, A., Colonna, M., Cozma, M. D., Czech, B., Di Toro, M., Famiano, M., Gannon, S., Gašparić, I., Grassi, L., Guazzoni, C., Guazzoni, P., Heil, M., Heilborn, L., Introzzi, R., Isobe, T., Kezzar, K., Kiš, M., Krasznahorkay, A., Kupny, S., Kurz, N., La Guidara, E., Lanzalone, G., Lasko, P., Le Fèvre, A., Leifels, Y., Lemmon, R. C., Li, Q. F., Lombardo, I., Łukasik, J., Lynch, W. G., Marini, P., Matthews, Z., May, L., Minniti, T., Mostazo, M., Pagano, A., Pagano, E. V., Papa, M., Pawłowski, P., Pirrone, S., Politi, G., Porto, F., Reviol, W., Riccio, F., Rizzo, F., Rosato, E., Rossi, D., Santoro, S., Sarantites, D. G., Simon, H., Skwirczynska, I., Sosin, Z., Stuhl, L., Trautmann, W., Trifirò, A., Trimarchi, M., Tsang, M. B., Verde, G., Veselsky, M., Vigilante, M., Wang, Yongjia, Wieloch, A., Wigg, P., Winkelbauer, J., Wolter, H. H., Wu, P., Yennello, S., Zambon, P., Zetta, L., and Zoric, M.

Subjects
energy: symmetry, QC1-999, Hadron, Nuclear Theory, Elementary particle, Astrophysics, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 7. Clean energy, 01 natural sciences, Nuclear physics, Physics and Astronomy (all), 0103 physical sciences, Neutron, ddc:530, 010306 general physics, Nuclear Experiment, Physics, 010308 nuclear & particles physics, Elliptic flow, gold, charged particle, Charged particle, Symmetry (physics), Darmstadt Lab, n: elliptic flow, nucleus: equation of state, density dependence, density, Baryon, Nucleon, light nucleus, saturation: density, experimental results
Abstract

International audience; The ASY-EOS experiment at GSI laboratory measured the direct and elliptic flow of neutrons and light charged particles in the reaction 197Au+197 Au at 400 A MeV incident energy. The ratio of elliptic flow of neutrons with respect to that of the light charged particles was used as main experimental observable to probe the density dependence of the symmetry energy term of the nuclear equation of state. Results, obtained by comparison of the experimental data with the UrQMD model predictions, strongly support a moderately soft to linear density dependence of the symmetry energy at suprasaturation densities below 2ρ0.

Published
2016
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15. ASY-EOS experiment at GSI: investigating the symmetry enenrgy at supra-satutation densities

Author

P. Russotto, M. Chartier, M. D. Cozma, E. De Filippo, A. Le Fevre, S. Gannon, A. Gašsparić, M. Kiš, S. Kupny, Y. Leifels, R. Lemmon, Q. Li, J. Lukasik, P. Marini, P. Pawlowski, S. Santoro, W. Trautmann, M. Veselsky, L. Acosta, M. Adamczyk, A. Al Ajlan, M. Al Garawi, S. Al Homaidhi, F. Amorini, L. Auditore, T. Aumann, Y. Ayyad, V. Baran, Z. Basrak, R. Bassini, J. Benlliure, C. Boiano, C. Boisjoli, K. Boretzky, J. Brzychczyk, A. Budzanowski, G. Cardella, P. Cammarata, Z. Chajecki, A. Chbihi, M. Colonna, B. Czech, M. Di Toro, M. Famiano, V. Greco, L. Grassi, C. Guazzoni, P. Guazzoni, M. Heil, L. Heilborn, R. Introzzi, T. Isobe, K. Kezzar, A. Krasznahorskay, N. Kurz, E. La Guidara, G. Lanzalone, P. Lasko, W. G. Lynch, Z. Matthews, L. May, T. Minniti, M. Mostazo, A. Pagano, M. Papa, S. Pirrone, R. Pleskac, G. Politi, F. Porto, R. Reifarth, W. Reisdorf, F. Riccio, F. Rizzo, D. Rossi, H. Simon, I. Skwirczynska, Z. Sosin, L. Stuhl, A. Trifirò, M. Trimarchi, M. B. Tsang, G. Verde, A. Wieloch, P. Wigg, H. H. Wolter, P. Wu, S. Yennello, P. Zambon, L. Zetta, M. Zoric, LOMBARDO, IVANO, ROSATO, ELIO, VIGILANTE, MARIANO, S. Lunardi, P.G. Bizzeti, C. Bucci, M. Chiari, A. Dainese, P. Di Nezza, R. Menegazzo, A. Nannini, C. Signorini, J.J. Valiente-Dobon, P., Russotto, M., Chartier, M. D., Cozma, E., De Filippo, A., Le Fevre, S., Gannon, A., Gašsparić, M., Kiš, S., Kupny, Y., Leifel, R., Lemmon, Q., Li, J., Lukasik, P., Marini, P., Pawlowski, S., Santoro, W., Trautmann, M., Veselsky, L., Acosta, M., Adamczyk, A., Al Ajlan, M., Al Garawi, S., Al Homaidhi, F., Amorini, L., Auditore, T., Aumann, Y., Ayyad, V., Baran, Z., Basrak, R., Bassini, J., Benlliure, C., Boiano, C., Boisjoli, K., Boretzky, J., Brzychczyk, A., Budzanowski, G., Cardella, P., Cammarata, Z., Chajecki, A., Chbihi, M., Colonna, B., Czech, M., Di Toro, M., Famiano, V., Greco, L., Grassi, C., Guazzoni, P., Guazzoni, M., Heil, L., Heilborn, R., Introzzi, T., Isobe, K., Kezzar, A., Krasznahorskay, N., Kurz, E., La Guidara, G., Lanzalone, P., Lasko, Lombardo, Ivano, W. G., Lynch, Z., Matthew, L., May, T., Minniti, M., Mostazo, A., Pagano, M., Papa, S., Pirrone, R., Pleskac, G., Politi, F., Porto, R., Reifarth, W., Reisdorf, F., Riccio, F., Rizzo, Rosato, Elio, D., Rossi, H., Simon, I., Skwirczynska, Z., Sosin, L., Stuhl, A., Trifirò, M., Trimarchi, M. B., Tsang, G., Verde, Vigilante, Mariano, A., Wieloch, P., Wigg, H. H., Wolter, P., Wu, S., Yennello, P., Zambon, L., Zetta, and M., Zoric

Subjects
flow, NUCLEAR COLLISIONS
Abstract

The elliptic-flow ratio of neutrons with respect to protons or light complex particles in reactions of heavy-ions at pre-relativistic energies has been proposed as an observable sensitive to the strength of the symmetry term of the nuclear equation of state at supra-saturation densities. The results obtained from the existing FOPI/LAND data for 197Au+197Au collisions at 400 MeV/nucleon in comparison with the UrQMD model simulations favoured a moderately soft symmetry term, but suffer from a considerable statistical uncertainty. These results have been confirmed by an independent analysis based on the Tübingen QMD simulations. In order to obtain an improved data set for Au+Au collisions and to extend the study to other systems, a new experiment was carried out at the GSI laboratory by the ASY-EOS collaboration. The present status of the data analysis is reported

Published
2014

16. The ASY-EOS Experiment at GSI

Author

Z. Basrak, A. Chbihi, Piotr Pawłowski, H. H. Wolter, Giuseppe Verde, Z. Matthews, S. Pirrone, Z. Chajecki, Maria Colonna, M. B. Tsang, J. Łukasik, F. Amorini, F. Rizzo, Abdulrahman Alajlan, Triestino Minniti, P. Cammarata, Marielle Chartier, Chiara Guazzoni, A. Budzanowski, Zbigniew Sosin, Qingfeng Li, L. Grassi, B. Czech, Martin Veselsky, F. Riccio, W. G. Lynch, N. Kurz, Vincenzo Greco, Yvonne Leifels, M. Boisjoli, Attila Krasznahorkay, Sherry Yennello, L. Stuhl, Herbert A. Simon, Mariano Vigilante, W. Trautmann, P. Russotto, S. Al-Homaidhi, W. Reisdorf, F. Porto, A. Wieloch, P. Wigg, E. La Guidara, K. Kezzar, I. Skwirczyńska, L. Zetta, Paola Marini, M. Kiš, M. Zoric, Igor Gašparić, G. Lanzalone, R. Pleskac, Elio Rosato, Angelo Pagano, M. D. Cozma, Lauren Heilborn, L. Acosta, E. De Filippo, Riccardo Introzzi, Roy Crawford Lemmon, S. Gannon, D. Rossi, M. Di Toro, C. Boiano, S. Kupny, G. Cardella, Michele Papa, M. Adamczyk, J. Benlliure, Rene Reifarth, P. Z. Wu, A. Trifirò, Yassid Ayyad, Matthias Heil, Ivano Lombardo, M. Al-Garawi, Tadaaki Isobe, P. Guazzoni, Michael Famiano, M. Trimarchi, R. Bassini, A. Le Fèvre, Thomas Aumann, J. Brzychczyk, Lucrezia Auditore, G. Politi, L. W. May, K. Boretzky, M. Mostazo, S. Santoro, P. Lasko, V. Baran, P. Zambon, Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Grand Accélérateur National d'Ions Lourds (GANIL), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Greco, V., Russotto, P., Chartier, M., Cozma, M. D., De Filippo, E., Le Fèvre, A., Gannon, S., Gašparić, I., Kiš, M., Kupny, S., Leifels, Y., Lemmon, R. C., Li, Q., Aukasik, J., Marini, P., Pawłowski, P., Trautmann, W., Acosta, L., Adamczyk, M., Al-Ajlan, A., Al-Garawi, M., Al-Homaidhi, S., Amorini, F., Auditore, L., Aumann, T., Ayyad, Y., Baran, V., Basrak, Z., Bassini, R., Benlliure, J., Boiano, C., Boisjoli, M., Boretzky, K., Brzychczyk, J., Budzanowski, A., Cardella, G., Cammarata, P., Chajecki, Z., Chbihi, A., Colonna, M., Czech, B., Di Toro, M., Famiano, M., Grassi, L., Guazzoni, C., Guazzoni, P., Heil, M., Heilborn, L., Introzzi, R., Isobe, T., Kezzar, K., Krasznahorkay, A., Kurz, N., La Guidara, E., Lanzalone, G., Lasko, P., Lombardo, I., Lynch, W. G., Matthews, Z., May, L., Minniti, T., Mostazo, M., Pagano, A., Papa, M., Pirrone, S., Pleskac, R., Politi, G., Porto, F., Reifarth, R., Reisdorf, W., Riccio, F., Rizzo, F., Rosato, E., Rossi, D., Santoro, S., Simon, H., Skwirczynska, I., Sosin, Z., Stuhl, L., Trifirò, A., Trimarchi, M., Tsang, M. B., Verde, G., Veselsky, M., Vigilante, M., Wieloch, A., Wigg, P., Wolter, H. H., Wu, P., Yennello, S., Zambon, P., Zetta, L., Zoric, M., Greco, Vincenzo, La Cognata, M., Pirrone, Sara, Rizzo, Francesca, Spitaleri, Claudio, and Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
DENSITY-DEPENDENCE, COLLISIONS, heavy ion: scattering, energy: symmetry, QC1-999, Hadron, Nuclear Theory, Elementary particle, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 01 natural sciences, Ion, Nuclear physics, Physics and Astronomy (all), quantum molecular dynamics: relativistic, symmetry energy, neutron flow, nuclear equation of state, heavy-ion scattering, relativistic quantum molecular dynamics, Darmstadt GSI FAIR, density dependence, transport theory, elliptic flow, 0.4 GeV/nucleon, 0103 physical sciences, Neutron, 010306 general physics, PROBE, Nuclear Experiment, numerical calculations, DETECTOR, Physics, density, DENSITY-DEPENDENCE, SYMMETRY ENERGY, COLLISIONS, FRAGMENTATION, DETECTOR, NEUTRON, PROBE, sezele, 010308 nuclear & particles physics, Elliptic flow, SYMMETRY ENERGY, charged particle, Charged particle, Baryon, n: flow, NEUTRON, Atomic physics, FRAGMENTATION, Nucleon, nucleus: equation of state
Abstract

International audience; The elliptic-flow ratio of neutrons with respect to protons or light complex particles in reactions of heavy ions at pre-relativistic energies has been proposed as an observable sensitive to the strength of the symmetry term of the nuclear equation of state at supra-saturation densities. In the ASY-EOS experiment at the GSI laboratory, flows of neutrons and light charged particles were measured for ^197Au+^197Au collisions at 400 MeV/nucleon. Flow results obtained for the Au+Au system, in comparison with predictions of the UrQMD transport model, confirm the moderately soft to linear density dependence of the symmetry energy deduced from the earlier FOPI-LAND data.

Published
2016
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17. ASY-EOS experiment at GSI

Author

S. Pirrone, Riccardo Introzzi, D. Loria, J. Brzychczyk, F. Amorini, Chiara Guazzoni, Marielle Chartier, Triestino Minniti, M. Trimarchi, A. Budzanowski, H. H. Wolter, L. W. May, M. Di Toro, M. Al-Garawi, M. Zoric, B. Tsang, B. Czech, L. Grassi, Z. Chajecki, E. La Guidara, C. Boisjoli, P. Z. Wu, Matthias Heil, Rene Reifarth, G. Politi, Yassid Ayyad, Martin Veselsky, K. Boretzky, Paola Marini, G. Cardella, F. Porto, P. Guazzoni, F. Riccio, Michael Famiano, J. Lukasik, Maria Colonna, Vincenzo Greco, Yvonne Leifels, A. Gašsparić, A. Trifirò, E. Geraci, I. Skwirczyńska, W. Reisdorf, L. Acosta, P. Zambon, A. Le Fèvre, Lauren Heilborn, Michele Papa, M. Adamczyk, Lucrezia Auditore, P. Cammarata, Thomas Aumann, Mihai Petrovici, Z. Basrak, A. Chbihi, Ivano Lombardo, Piotr Pawłowski, S. Cavallaro, Z. Matthews, M. Mostazo, P. Russotto, J. Wilczyński, S. Santoro, P. Lasko, Tadaaki Isobe, F. Rizzo, V. Baran, D. M. Rossi, Zbigniew Sosin, Qingfeng Li, Mariano Vigilante, W. Trautmann, G. Lanzalone, W. G. Lynch, M. Kiš, J. Benlliure, Elio Rosato, S. Al-Homaidhi, C. Boiano, A. Wieloch, Angelo Pagano, E. De Filippo, Abdulrahman Alajlan, Roy Crawford Lemmon, S. Kupny, Sherry Yennello, N. Kurz, L. Zetta, Herbert A. Simon, P. Wigg, K. Kezzar, Giuseppe Verde, Grand Accélérateur National d'Ions Lourds (GANIL), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), J.D Frankland, A. Pagano, S. Pirrone, M.-F Rivet, F. Rizzo, J.D.Frankland, A.Pagano, S.Pirrone, m.F.Rivet, F.Rizzo, P., Russotto, L., Acosta, M., Adamczyk, A., Al Ajlan, M., Al Garawi, S., Al Homaidhi, F., Amorini, L., Auditore, T., Aumann, Y., Ayyad, V., Baran, Z., Basrak, J., Benlliure, C., Boiano, C., Boisjoli, K., Boretzky, J., Brzychczyk, A., Budzanowski, G., Cardella, P., Cammarata, S., Cavallaro, Z., Chajecki, M., Chartier, A., Chbihi, M., Colonna, B., Czech, E., De Filippo, M., Di Toro, M., Famiano, A., Le Fevre, A., Ga??spari??, E., Geraci, L., Grassi, V., Greco, C., Guazzoni, P., Guazzoni, M., Heil, L., Heilborn, R., Introzzi, T., Isobe, K., Kezzar, M., Ki??, S., Kupny, N., Kurz, E., La Guidara, G., Lanzalone, P., Lasko, Y., Leifel, R., Lemmon, Q., Li, Lombardo, Ivano, D., Loria, J., Lukasik, W. G., Lynch, P., Marini, Z., Matthew, L., May, T., Minniti, M., Mostazo, A., Pagano, M., Papa, P., Pawlowski, M., Petrovici, S., Pirrone, G., Politi, F., Porto, R., Reifarth, W., Reisdorf, F., Riccio, F., Rizzo, Rosato, Elio, D., Rossi, S., Santoro, H., Simon, I., Skwirczynska, Z., Sosin, W., Trautmann, A., Trifirò, M., Trimarchi, B., Tsang, M., Veselsky, G., Verde, Vigilante, Mariano, A., Wieloch, P., Wigg, J., Wilczynski, H. H., Wolter, P., Wu, S., Yennello, P., Zambon, L., Zetta, M., Zoric, Russotto, P., Acosta, L., Adamczyk, M., Al-Ajlan, A., Al-Garawi, M., Al-Homaidhi, S., Amorini, F., Auditore, L., Aumann, T., Ayyad, Y., Baran, V., Basrak, Z., Benlliure, J., Boiano, C., Boisjoli, M., Boretzky, K., Brzychczyk, J., Budzanowski, A., Cardella, G., Cammarata, P., Cavallaro, S., Chajecki, Z., Chartier, M., Chbihi, A., Colonna, M., Czech, B., De Filippo, E., Di Toro, M., Famiano, M., Le Fevre, A., Gašparić, I., Geraci, E., Grassi, L., Greco, V., Guazzoni, C., Guazzoni, P., Heil, M., Heilborn, L., Introzzi, R., Isobe, T., Kezzar, K., Kiš, M., Kupny, S., Kurz, N., La Guidara, E., Lanzalone, G., Lasko, P., Leifels, Y., Lemmon, R., Li, Q., Lombardo, I., Loria, D., Lukasik, J., Lynch, W., Marini, P., Matthews, Z., May, L., Minniti, T., Mostazo, M., Pagano, A., Papa, M., Pawlowski, P., Petrovici, M., Pirrone, S., Politi, G., Porto, F., Reifarth, R., Reisdorf, W., Riccio, F., Rizzo, F., Rosato, E., Rossi, D., Santoro, S., Simon, H., Skwirczynska, I., Sosin, Z., Trautmann, W., Trifirò, A., Trimarchi, M., Tsang, B., Veselsky, M., Verde, G., Vigilante, M., Wieloch, A., Wigg, P., Wilczynski, J., Wolter, H., Wu, P., Yennello, S., Zambon, P., Zetta, L., and Zoric, M.

Subjects
Physics, sezele, QC1-999, Nuclear Theory, symmetry energy, Observable, Nuclear equation of state, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], nuclear equation of state, Symmetry (physics), Term (time), Nuclear physics, Physics and Astronomy (all), nucleus-nucleus collisions, Neutron, Nucleon, Nuclear Experiment
Abstract

The elliptic-flow ratio of neutrons with respect to protons in reactions of neutron rich Heavy-Ion at intermediate energies has been recently proposed as an observable sensitive to the strength of the symmetry term in the nuclear equation of state (EOS) at supra-saturation densities. The recent results obtained from the existing FOPI/LAND data for 197Au+197Au collisions at 400 MeV/nucleon in comparison with the UrQMD model allowed a first estimate of the symmetry term of the EOS but suffer from a considerable statistical uncertainty. In order to obtain an improved data set for Au+Au collisions and to extend the study to other systems, a new experiment was carried out at the GSI laboratory by the ASY-EOS collaboration in May 2011. © Owned by the authors, 2012.

Published
2012
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18. The ASY-EOS experiment at GSI: Constraining the symmetry energy at supra-saturation densities

Author

P. Russotto, M. Chartier, M.D. Cozma, E. De Filippo, A. Le Fèvre, S. Gannon, I. Gašparić, M. Kiš, S. Kupny, Y. Leifels, R.C. Lemmon, Q. Li, J. Łukasik, P. Marini, P. Pawłowski, W. Trautmann, L. Acosta, M. Adamczyk, A. Al-Ajlan, M. Al-Garawi, S. Al-Homaidhi, F. Amorini, L. Auditore, T. Aumann, Y. Ayyad, V. Baran, Z. Basrak, R. Bassini, J. Benlliure, C. Boiano, M. Boisjoli, K. Boretzky, J. Brzychczyk, A. Budzanowski, G. Cardella, P. Cammarata, Z. Chajecki, A. Chbihi, M. Colonna, B. Czech, M. Di Toro, M. Famiano, V. Greco, L. Grassi, C. Guazzoni, P. Guazzoni, M. Heil, L. Heilborn, R. Introzzi, T. Isobe, K. Kezzar, A. Krasznahorkay, N. Kurz, E. La Guidara, G. Lanzalone, P. Lasko, I. Lombardo, W.G. Lynch, Z. Matthews, L. May, T. Minniti, M. Mostazo, A. Pagano, M. Papa, S. Pirrone, R. Pleskac, G. Politi, F. Porto, R. Reifarth, W. Reisdorf, F. Riccio, F. Rizzo, E. Rosato, D. Rossi, S. Santoro, H. Simon, I. Skwirczynska, Z. Sosin, L. Stuhl, A. Trifirò, M. Trimarchi, M.B. Tsang, G. Verde, M. Veselsky, M. Vigilante, A. Wieloch, P. Wigg, H.H. Wolter, P. Wu, S. Yennello, P. Zambon, L. Zetta, M. Zoric, Borderie, B., Russotto, P., Chartier, M., Cozma, M. D., De Filippo, E., Le Fever, A., Gannon, S., Gǎsparíc, I., Kǐs, M., Kupny, S., Leifels, Y., Lemmon, R. C., Li, Q., Lukasik, J., Marini, P., Pawlowski, P., Trautmann, W., Acosta, L., Adamczyk, M., Al-Ajlan, A., Al-Garawi, M., Al-Homaidhi, S., Amorini, F., Auditore, L., Aumann, T., Ayyad, Y., Baran, V., Basrak, Z., Bassini, R., Benlliure, J., Boiano, C., Boisjoli, M., Boretzky, K., Brzychczyk, J., Budzanowski, A., Cardella, G., Cammarata, P., Chajecki, Z., Chbihi, A., Colonna, M., Czech, B., Di Toro, M., Famiano, M., Greco, V., Grassi, L., Guazzoni, C., Guazzoni, P., Heil, M., Heilborn, L., Introzzi, R., Isobe, T., Kezzar, K., Krasznahorkay, A., Kurz, N., La Guidara, E., Lanzalone, G., Lasko, P., Lombardo, I., Lynch, W. G., Matthews, Z., May, L., Minniti, T., Mostazo, M., Pagano, A., Papa, M., Pirrone, S., Pleskac, R., Politi, G., Porto, F., Reifarth, R., Reisdorf, W., Riccio, F., Rizzo, F., Rosato, E., Rossi, D., Santoro, S., Simon, H., Skwirczynska, I., Sosin, Z., Stuhl, L., Trifiro, A., Trimarchi, M., Tsang, M. B., Verde, G., Veselsky, M., Vigilante, M., Wieloch, A., Wigg, P., Wolter, H. H., Wu, P., Yennello, S., Zambon, P., Zetta, L., Zoric, M., Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Grand Accélérateur National d'Ions Lourds (GANIL), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Physics and Astronomy (all), sezele, Physics, QC1-999, Nuclear Theory, ddc:530, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], Nuclear Experiment
Abstract

International audience; The elliptic-flow ratio of neutrons with respect to protons or lightcomplex particles in reactions of heavy ions at pre-relativistic energieshas been proposed as an observable sensitive to the strength of thesymmetry term of the nuclear equation of state at supra-saturationdensities. In the ASY-EOS experiment at the GSI laboratory, flows ofneutrons and light charged particles were measured for 197Au+197Au,96Zr+96Zr and 96Ru+96Ru collisions at 400 MeV/nucleon with theLarge Area Neutron Detector LAND as part of a setup with severaladditional detection systems used for the event characterization. Flowresults obtained for the Au+Au system, in comparison with predictionsof the UrQMD transport model, confirm the moderately soft to lineardensity dependence of the symmetry energy deduced from the earlierFOPI-LAND data.

Published
2015
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19. Geant4 simulation of a 3D high resolution gamma camera

Author

J. Gerl, M. Al-Garawi, K. Kezzar, S. AlGhamdi, N. Assemi, F. Aksouh, and H. Akhdar

Subjects
Physics, Scintillation, Scattering, business.industry, Astrophysics::High Energy Astrophysical Phenomena, Detector, Compton scattering, Lyso, Collimated light, law.invention, Optics, law, Sensitivity (control systems), business, Instrumentation, Mathematical Physics, Gamma camera
Abstract

The aim of this work is to develop a 3D gamma camera with high position resolution and sensitivity relying on both distance/absorption and Compton scattering techniques and without using any passive collimation. The proposed gamma camera is simulated in order to predict its performance using the full benefit of Geant4 features that allow the construction of the needed geometry of the detectors, have full control of the incident gamma particles and study the response of the detector in order to test the suggested geometries. Three different geometries are simulated and each configuration is tested with three different scintillation materials (LaBr3, LYSO and CeBr3).

Published
2015
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21. Synthesis and Characterization of New Amino Acid-Schiff Bases and Studies their Effects on the Activity of ACP, PAP and NPA Enzymes (In Vitro)

Author

Salim M. Al-Garawi, Zahraa, Hameed R. Tomi, Ivan, and Hussein R. Al-Daraji, Ali

Abstract

In this study, two new Schiff base compounds derived from the condensation reaction of L-glycine and L-tryptophan with 4-methylbenzal-dehyde have been synthesized. The Schiff base compounds were characterized by FT-IR, UV and 1H NMR spectroscopy. Their effects on the activity of total (ACP), prostatic (PAP) and non prostatic (NPA) acid phosphatase enzymes were studied. The Schiff base derived from L-glycine (A) demonstrated inhibition effect on the ACP and NPA activities and activation effect on PAP activity. The Schiff base derived from L-tryptophan (B) demonstrated semi fixed inhibition effects on the ACP and NPA activities at high concentrations (5.5×10-2, 5.5×10-3 and 5.5×10-4 M) and activator effect at low concentration (5.5×10-5 M) while it was exhibits as activator on PAP activity.

Published
2012
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22. The ASY-EOS experiment at GSI: Investigating the symmetry energy at supra-saturation densities

Author

Lunardi, S., Russotto, P., Chartier, M., Cozma, M. D., De Filippo, E., Le Fèvre, A., Gannon, S., Gašparić, I., Kiš, M., Kupny, S., Leifels, Y., Lemmon, R. C., Li, Q., Łukasik, J., Marini, P., Pawłowski, P., Santoro, S., Trautmann, W., Veselsky, M., Acosta, L., Adamczyk, M., Al Ajlan, A., Al Garawi, M., Al Homaidhi, S., Amorini, F., Auditore, L., Aumann, T., Ayyad, Y., Baran, V., Basrak, Z., Bassini, R., Benlliure, J., Boiano, C., Boisjoli, M., Boretzky, K., Brzychczyk, J., Budzanowski, A., Cardella, G., Cammarata, P., Chajecki, Z., Chbihi, A., Colonna, M., Czech, B., Di Toro, M., Famiano, M., Greco, V., Grassi, L., Guazzoni, C., Guazzoni, P., Heil, M., Heilborn, L., Introzzi, Riccardo, Isobe, T., Kezzar, K., Krasznahorkay, A., Kurz, N., La Guidara, E., Lanzalone, G., Lasko, P., Lombardo, I., Lynch, W. G., Matthews, Z., May, L., Minniti, T., Mostazo, M., Pagano, A., Papa, M., Pirrone, S., Pleskac, R., Politi, G., Porto, F., Reifarth, R., Reisdorf, W., Riccio, F., Rizzo, F., Rosato, E., Rossi, D., Simon, H., Skwirczynska, I., Sosin, Z., Stuhl, L., Trifirò, A., Trimarchi, M., Tsang, M. B., Verde, G., Vigilante, M., Wieloch, A., Wigg, P., Wolter, H. H., Wu, P., Yennello, S., Zambon, P., Zetta, L., Zoric, M., Bizzeti, P. G., Bucci, C., Chiari, M., Dainese, A., Di Nezza, P., Menegazzo, R., Nannini, A., Signorini, C., Valiente Dobon, J. J., Grand Accélérateur National d'Ions Lourds (GANIL), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Russotto, P., Chartier, M., Filippo, E., Fèvre, A., Gannon, S., Gaparić, I., Ki, M., Kupny, S., Leifels, Y., Lemmon, R., Ukasik, J., Marini, P., Pagano, A., Pawowski, P., Santoro, S, Trautmann, W., Veselsky, M., Acosta, L., Adamczyk, M., Al-Ajlan, A., Al-Garawi, M., Al-Homaidhi, S., Amorini, F., Auditore, L., Aumann, T., Ayyad, Y., Baran, V., Basrak, Z., Benlliure, J., Boiano, C., Boisjoli, M., Boretzky, K., Brzychczyk, J., Budzanowski, A., Cardella, G., Cammarata, P., Chajecki, Z., Chbihi, A., Colonna, M., Cozma, D., Czech, B., Toro, M., Famiano, M., Geraci, E., Greco, V., Grassi, L., Guazzoni, C., Guazzoni, P., Heil, M., Heilborn, L., Introzzi, R., Isobe, T., Kezzar, K., Krasznahorkay, A., Kurz, N., Guidara, E., Lanzalone, G., Lasko, P., Li, Q., Lombardo, I., Lynch, W., Matthews, Z., May, L., Minniti, T., Mostazo, M., Papa, M., Pirrone, S., Politi, G., Porto, F., Reifarth, R., Reisdorf, W., Riccio, F., Rizzo, F., Rosato, E., Rossi, D., Simon, H., Skwirczynska, I., Sosin, Z., Stuhl, L., Trifirò, A., Trimarchi, M., Tsang, M., Verde, G., Vigilante, M., Wieloch, A., Wigg, P., Wolter, H., Wu, P., Yennello, S., Zambon, P., Zetta, L., Zoric, M., B.A.Li and J.B.Natowitz, P., Russotto, M., Chartier, E., De Filippo, A., Le Fevre, S., Gannon, A., Ga??spari??, M., Ki??, S., Kupny, Y., Leifel, R., Lemmon, J., Lukasik, P., Marini, A., Pagano, P., Pawlowski, S., Santoro, W., Trautmann, M., Veselsky, L., Acosta, M., Adamczyk, A., Al Ajlan, M., Al Garawi, S., Al Homaidhi, F., Amorini, L., Auditore, T., Aumann, Y., Ayyad, V., Baran, Z., Basrak, J., Benlliure, C., Boiano, C., Boisjoli, K., Boretzky, J., Brzychczyk, A., Budzanowski, G., Cardella, P., Cammarata, Z., Chajecki, A., Chbihi, M., Colonna, B., Czech, M., Di Toro, M., Famiano, E., Geraci, L., Grassi, V., Greco, C., Guazzoni, P., Guazzoni, M., Heil, L., Heilborn, R., Introzzi, T., Isobe, K., Kezzar, A., Krasznahorskay, N., Kurz, E., La Guidara, G., Lanzalone, P., Lasko, Q., Li, I., Lombardo, W. G., Lynch, Z., Matthew, L., May, T., Minniti, M., Mostazo, M., Papa, S., Pirrone, G., Politi, F., Porto, R., Reifarth, W., Reisdorf, F., Riccio, F., Rizzo, Rosato, Elio, D., Rossi, H., Simon, I., Skwirczynska, Z., Sosin, A., Trifirò, M., Trimarchi, M. B., Tsang, G., Verde, Vigilante, Mariano, A., Wieloch, P., Wigg, H. H., Wolter, P., Wu, S., Yennello, P., Zambon, L., Zetta, M., Zoric, Cozma, M., De Filippo, E., Le Fèvre, A., Gašparić, I., Kiš, M., Łukasik, J., Pawłowski, P., Santoro, S., Bassini, R., Di Toro, M., La Guidara, E., and Pleskac, R.

Subjects
Particle physics, History, QC1-999, Nuclear Theory, FOS: Physical sciences, and isobaric spin 24.10.Pa Thermal and statistical models, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], Education, Nuclear physics, Physics and Astronomy (all), nuclear physics, heavy-ions, symmetry energy, Au+Au collisions, Neutron, Nuclear Experiment (nucl-ex), Nuclear Experiment, ComputingMilieux_MISCELLANEOUS, Physics, sezele, Order (ring theory), Nuclear equation of state, Observable, 21.65.-f Nuclear matter 27.80.+w 190(less-than-or-equal-to)A(less-than-or-equal-to)219 24.60.-k Statistical theory and fluctuations 25.75.Gz Particle correlations and fluctuations 21.10.Hw Spin, Symmetry (physics), Term (time), Computer Science Applications, parity, Nuclear reactions, Saturation (chemistry), Nucleon, Energy (signal processing)
Abstract

The elliptic-flow ratio of neutrons with respect to protons in reactions of neutron rich heavy-ions systems at intermediate energies has been proposed as an observable sensitive to the strength of the symmetry term in the nuclear Equation Of State (EOS) at supra-saturation densities. The recent results obtained from the existing FOPI/LAND data for $^{197}$Au+$^{197}$Au collisions at 400 MeV/nucleon in comparison with the UrQMD model allowed a first estimate of the symmetry term of the EOS but suffer from a considerable statistical uncertainty. In order to obtain an improved data set for Au+Au collisions and to extend the study to other systems, a new experiment was carried out at the GSI laboratory by the ASY-EOS collaboration in May 2011., Comment: Talk given by P. Russotto at the 11th International Conference on Nucleus-Nucleus Collisions (NN2012), San Antonio, Texas, USA, May 27-June 1, 2012. To appear in the NN2012 Proceedings in Journal of Physics: Conference Series (JPCS)

Published
2013
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