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The antib acterial and antifungal activi ties of Terminalia arjuna, Tephrosia purpurea and Thuja occidentalis extracts w ere investigated against the standard drugs , which are presen tly available in the market as G entam i cin, Cephradine , Amoxicillin c lavulanate, Norfloxacin and Itraconazole . W ell m ethod was used for antimicrobial activity and the zone s of inhibition were measured in m illi m eters . The antibacterial activity was observed on three gram negative bacteria i.e. Escherichia coli, Klebsiella pneumonia and Pseudomonas aeruginosa and one gram positive bacteria i.e. Staphy lococcus aureus . The antifungal activity was investigat ed against Candida albicans and Aspergillus niger . The cytotoxic effects (LD 50 ) of the crude extracts we re also observed on brine shrimps ( Artemia salina ) using E toposide a s an internal standard . The crude extract of T . arjuna bark exhibited less potent antimicrobial activity as compare d to crude extract of T . arjuna heart wood. Bark extract of T. arjuna show ed no cytotoxic activity but heart wood extract sho w ed this activit y in b rine s hrimp b ioassay technique . The crude extract of T . purpurea show ed positive cytotoxic, potent antibacterial but no antifungal activity . The crude extract of T . occidentalis show ed good antibacterial low antifungal and low cytotoxic activity. T. arjuna showed most potent antimicrobial and cytotoxic activity while T. Purpurea and T. oocidentalis posses less potent activities.