460 results on '"M Quante"'
Search Results
2. Improving gastrointestinal cancer therapy by uniting stakeholders
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M. Quante, A. Saborowski, and C.B. Westphalen
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precision medicine ,GI oncology ,academic research ,industry participation ,technology ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Gastrointestinal (GI) cancer—an umbrella term for cancers that affect the digestive system and other abdominal organs—includes some malignancies with the lowest survival rates. To improve patient outcomes, patients must have access to optimal treatment including precision oncology, a method of determining the most effective treatment for an individual cancer patient by identifying predictive biomarkers through the use of advanced molecular diagnostics. While many powerful molecular profiling technologies have already been developed, their uptake in the management of GI cancers could be improved. To bridge this gap, better coordination among three interdependent stakeholders—scientists, clinicians, and industry professionals—is essential. The first Translational and Precision GI-Oncology—Bench to Bedside Meeting was held on 23-28 April 2023 in Freiburg, Germany. The 3-day meeting offered the opportunity for scientists, clinicians, and industry professionals in the field of GI cancer to exchange ideas about how to improve the translation of basic science into clinical practice. One-hundred and twenty participants attended the meeting, which featured 47 presentations covering the following five topics: bedside, analytical approaches for treatment and real-world data, new ideas and biomarkers, novel technologies, and drugs. A summary of the 2023 meeting is provided in this report.
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- 2024
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3. Submesoscale dispersion of surface drifters in a coastal sea near offshore wind farms
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U. Callies, R. Carrasco, J. Floeter, J. Horstmann, and M. Quante
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Geography. Anthropology. Recreation ,Environmental sciences ,GE1-350 - Abstract
We analysed relative dispersion of surface drifters released as pairs (six instances) or triplets (two instances) during three field experiments conducted in the German Bight in close proximity to wind farms. There is some tentative evidence that nearly exponential growth of relative dispersion (non-local dispersion) preferably occurs for drifter pairs that are most exposed to the influence of a wind farm. Kinetic energy spectra and velocity structure functions are analysed with regard to the assumption that turbulent energy could be injected by tides, possibly also via an interaction between tidal currents and wind turbine towers. Applicability of inertial range turbulence theory, however, can be doubted given distinct peaks of overtides observed in velocity power spectra. More comprehensive studies would be needed to better separate submesoscale effects of wind farms, tides and possibly baroclinic instabilities on observed drifter behaviour in a complex coastal environment.
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- 2019
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4. Effects of ship emissions on air quality in the Baltic Sea region simulated with three different chemistry transport models
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M. Karl, J. E. Jonson, A. Uppstu, A. Aulinger, M. Prank, M. Sofiev, J.-P. Jalkanen, L. Johansson, M. Quante, and V. Matthias
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Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
The Baltic Sea is a highly frequented shipping area with busy shipping lanes close to densely populated regions. Exhaust emissions from ship traffic into the atmosphere do not only enhance air pollution, they also affect the Baltic Sea environment through acidification and eutrophication of marine waters and surrounding terrestrial ecosystems. As part of the European BONUS project SHEBA (Sustainable Shipping and Environment of the Baltic Sea region), the transport, chemical transformation and fate of atmospheric pollutants in the Baltic Sea region were simulated with three regional chemistry transport model (CTM) systems, CMAQ, EMEP/MSC-W and SILAM, with grid resolutions between 4 and 11 km. The main goal was to quantify the effect that shipping emissions have on the regional air quality in the Baltic Sea region when the same shipping emission dataset but different CTMs are used in their typical set-ups. The performance of these models and the shipping contribution to the results of the individual models were evaluated for sulfur dioxide (SO2), nitrogen dioxide (NO2), ozone (O3) and particulate matter (PM2.5). Model results from the three CTMs for total air pollutant concentrations were compared to observations from rural and urban background stations of the AirBase monitoring network in the coastal areas of the Baltic Sea region. Observed PM2.5 in summer was underestimated strongly by CMAQ and to some extent by EMEP/MSC-W. Observed PM2.5 in winter was underestimated by SILAM. In autumn all models were in better agreement with observed PM2.5. The spatial average of the annual mean O3 in the EMEP/MSC-W simulation was ca. 20 % higher compared to the other two simulations, which is mainly the consequence of using a different set of boundary conditions for the European model domain. There are significant differences in the calculated ship contributions to the levels of air pollutants among the three models. EMEP/MSC-W, with the coarsest grid, predicted weaker ozone depletion through NO emissions in the proximity of the main shipping routes than the other two models. The average contribution of ships to PM2.5 levels in coastal land areas is in the range of 3.1 %–5.7 % for the three CTMs. Differences in ship-related PM2.5 between the models are mainly attributed to differences in the schemes for inorganic aerosol formation. Differences in the ship-related elemental carbon (EC) among the CTMs can be explained by differences in the meteorological conditions, atmospheric transport processes and the applied wet-scavenging parameterizations. Overall, results from the present study show the sensitivity of the ship contribution to combined uncertainties in boundary conditions, meteorological data and aerosol formation and deposition schemes. This is an important step towards a more reliable evaluation of policy options regarding emission regulations for ship traffic and the planned introduction of a nitrogen emission control area (NECA) in the Baltic Sea and the North Sea in 2021.
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- 2019
- Full Text
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5. Outcomes of gynecologic cancer surgery during the COVID-19 pandemic: an international, multicenter, prospective CovidSurg-Gynecologic Oncology Cancer study
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Nepogodiev, Dmitri, Siaw-Acheampong, Kwabena, Benson, Ruth A., Bywater, Edward, Chaudhry, Daoud, Dawson, Brett E., Evans, Jonathan P., Glasbey, James C., Gujjuri, Rohan R., Heritage, Emily, Jones, Conor S., Kamarajah, Sivesh K., Khatri, Chetan, Khaw, Rachel A., Keatley, James M., Knight, Andrew, Lawday, Samuel, Li, Elizabeth, Mann, Harvinder S., Marson, Ella J., McLean, Kenneth A., Mckay, Siobhan C., Mills, Emily C., Pellino, Gianluca, Picciochi, Maria, Taylor, Elliott H., Tiwari, Abhinav, Simoes, Joana FF., Trout, Isobel M., Venn, Mary L., Wilkin, Richard JW., Bhangu, Aneel, Abbott, Tom EF., Abukhalaf, Sadi, Adamina, Michel, Ademuyiwa, Adesoji O., Agarwal, Arnav, Akkulak, Murat, Alameer, Ehab, Alderson, Derek, Alakaloko, Felix, Albertsmeier, Markus, Alser, Osaid, Alshaar, Muhammad, Alshryda, Sattar, Arnaud, Alexis P., Augestad, Knut Magne, Ayasra, Faris, Azevedo, José, Bankhead-Kendall, Brittany K., Barlow, Emma, Beard, David, Blanco-Colino, Ruth, Brar, Amanpreet, Minaya-Bravo, Ana, Breen, Kerry A., Bretherton, Chris, Buarque, Igor Lima, Burke, Joshua, Caruana, Edward J., Chaar, Mohammad, Chakrabortee, Sohini, Christensen, Peter, Cox, Daniel, Cukier, Moises, Cunha, Miguel F., Davidson, Giana H., Desai, Anant, Di Saverio, Salomone, Drake, Thomas M., Edwards, John G., Elhadi, Muhammed, Emile, Sameh, Farik, Shebani, Fiore, Marco, Fitzgerald, J Edward, Ford, Samuel, Garmanova, Tatiana, Gallo, Gaetano, Ghosh, Dhruva, Ataíde Gomes, Gustavo Mendonça, Grecinos, Gustavo, Griffiths, Ewen A., Gruendl, Magdalena, Halkias, Constantine, Harrison, Ewen M., Hisham, Intisar, Hutchinson, Peter J., Hwang, Shelley, Isik, Arda, Jenkinson, Michael D., Jonker, Pascal, MA Kaafarani, Haytham, Keller, Debby, Kolias, Angelos, Kruijff, Schelto, Lawani, Ismail, Lederhuber, Hans, Leventoglu, Sezai, Litvin, Andrey, Loehrer, Andrew, Löffler, Markus W., Lorena, Maria Aguilera, Modolo, Maria Marta, Major, Piotr, Martin, Janet, Mashbari, Hassan N., Mazingi, Dennis, Metallidis, Symeon, Mohan, Helen M., Moore, Rachel, Moszkowicz, David, Moug, Susan, Ng-Kamstra, Joshua S., Maimbo, Mayaba, Negoi, Ionut, Niquen, Milagros, Ntirenganya, Faustin, Olivos, Maricarmen, Oussama, Kacimi, Outani, Oumaima, Parreno-Sacdalanm, Marie Dione, Pata, Francesco, Perez Rivera, Carlos Jose, Pinkney, Thomas D., van der Plas, Willemijn, Pockney, Peter, Qureshi, Ahmad, Radenkovic, Dejan, Ramos-De la Medina, Antonio, Richards, Toby, Roberts, Keith, Roslani, April C., Rutegård, Martin, Segura-Sampedro, Juan José, Santos, Irène, Satoi, Sohei, Sayyed, Raza, Schache, Andrew, Schnitzbauer, Andreas A., Seyi-Olajide, Justina O., Sharma, Neil, Shaw, Catherine A., Shaw, Richard, Shu, Sebastian, Soreide, Kjetil, Spinelli, Antonino, Stewart, Grant D., Sund, Malin, Sundar, Sudha, Tabiri, Stephen, Townend, Philip, Tsoulfas, Georgios, van Ramshorst, Gabrielle H., Vidya, Raghavan, Vimalachandran, Dale, Warren, Oliver J., Wedderburn, Duane, Wright, Naomi, Booth, Lesley, Barker, Neil, Cooke, Shirley, Doré, Suzanne, Horwood, Nigel, Runigamugabo, Emmy, Weir, Carrie Tierney, Dajti I, Albania, C, Allemand, LA, Boccalatte, M, Figari, M, Lamm, J, Larrañaga, C, Marchitelli, F, Noll, D, Odetto, M, Perrotta, J, Saadi, L, Zamora, Ballester, A.M., KE, Tapper, N, Zeff, JI, Valenzuela, C, Alurralde, J, Anastasio, Perez de Nucci A, Apas, EL, Caram, D, Eskinazi, JP, Mendoza, M, Usandivaras, R, Badra, A, Esteban, JS, García, PM, García, JI, Gerchunoff, Lucchini, S.M., NIgra, M.A., L, Vargas, T, Hovhannisyan, A, Stepanyan, CE, Vasey, EGR, Watson, C, Ip, J, Kealey, CSH, Lim, S, Sengupta, S, Ward, E, Wong, T, Gould, R, Gourlay, B, Griffiths, S, Gananadha, M, McLaren, J, Cecire, N, Joshi, S, Salindera, A, Sutherland, JH, Ahn, G, Charlton, S, Chen, N, Gauri, R, Hayhurst, S, Jang, F, Jia, C, Mulligan, W, Yang, G, Ye, H, Zhang, M, Ballal, D, Gibson, D, Hayne, H, McMillan, J, Moss, MJ, Pugliese, T, Richards, YTN, Seow, A, Thian, P, Viswambaram, UG, Vo, J, Bennetts, T, Bright, Brooke-Smith, M., R, Fong, B, Gricks, L, Huang, YH, Lam, A, Nathan, Ong, B.S., E, Ooi, M, Szpytma, D, Watson, K, Bagraith, S, Caird, E, Chan, C, Dawson, D, Ho, N, Hui, S, Izwan, E, Jeyarajan, S, Jordan, R, Liang, A, Lim, GJ, Nolan, A, Oar, D, Parker, H, Puhalla, A, Quennell, L, Rutherford, C, Sommerville, P, Townend, Papen M, Von, M, Wullschleger, AC, Dawson, A, Drane, A, Blatt, D, Cope, N, Egoroff, M, Fenton, J, Gani, N, Lott, P, Pockney, N, Shugg, M, Elliott, D, Phung, D, Phan, D, Townend, C, Bong, J, Gundara, A, Frankel, S, Bowman, GR, Guerra, N, Gerns, S, McGeorge, A, Riddell, M, Roberts, N, Rukin, J, Bolt, K, Buddingh, Dudi-Venkata, N.N., S, Jog, HM, Kroon, T, Sammour, R, Smith, C, Stranz, M, Batstone, K, Lah, W, McGahan, D, Mitchell, A, Morton, A, Pearce, G, Sheahan, B, Swinson, A, Waldron, P, Walker, N, Alam, S, Banting, L, Chong, P, Choong, S, Clatworthy, D, Foley, A, Fox, MW, Hii, B, Knowles, J, Mack, M, Read, A, Rowcroft, G, Wright, EWY, Lun, M, Lanner, J, Burtscher, Trivik-Barrientos, F., I, Königsrainer, M, Bauer, C, Freyschlag, M, Kafka, F, Messner, D, Öfner, I, Tsibulak, S, Holawe, M, Zimmermann, K, Emmanuel, M, Grechenig, R, Gruber, M, Harald, L, Öhlberger, J, Presl, A, Wimmer, İ, Namazov, E, Samadov, D, Barker, R, Boyce, S, Corbin, A, Doyle, A, Eastmond, R, Gill, A, Haynes, S, Millar, M, O’Shea, G, Padmore, N, Paquette, E, Phillips, John S, St., K, Walkes, J, Abeloos, Backer T, De, Ceulaer J, De, C, Dick, Diez-Fraile, A., P, Lamoral, C, Spaas, W, Ceelen, P, Pattyn, D, Van de putte, Nieuwenhove Y, Van, Ramshorst G, Van, Willaert, W., Bazzett-Matabele, L., SP, Chiyapo, Ramogola-Masire, D., G, Ramontshonyana, A, Seiphetlheng, P, Vuylsteke, EA, Abdallah, Júnior S, Aguiar, G, Baiocchi, GB, Carvalho, FJF, Coimbra, LP, Kowalski, F, Makdissi, N, Marques, T, Marques, Santos S, Soares Dos, Gonçalves B, Tirapelli, JG, Vartanian, Reis R, Dos, P, Camara, Lima RK, De, Giustina E, Della, PV, Hoffmann, A, Gatti, C, Nardi, R, Oliva, L, Nacif, Ferro C, Carvalho, Ataíde G, Gomes Mendonça, Buarque I, Lima, A, Lira dos Santos Leite, Pol-Fachin, L., Bezerra T, Santos, Ramos da Silva A, Maylson, de Araújo Silvestre D, Windson, Barros A, Vieira, L, Campbell, Cicco R, De, I, Cecconello, P, Gregorio, Lima L, Pontual, Junior U, Ribeiro, FR, Takeda, RM, Terra, Teixeira M, Faccini, Kulcsar, M.A.V., LL, Matos, KS, Nunes, G, Laporte, M, Salem, Awada J, Barakat, TR, Ijichi, NJ, Kim, A, Marreiro, B, Muller, R, Nunes, B, Bodanese, ER, Eidt, JC, Isoton, Vieira da Cunha M, Lemos, de Sampaio L, Regina, C, Vendrame, M, Zeni, JA, Zortéa, MR, Zortéa, M, Sokolov, B, Kidane, S, Srinathan, A, Munro, L, Helyer, D, McKeen, M, Boutros, NG, Caminsky, G, Ghitulescu, G, Jamjoum, J, Moon, J, Pelletier, T, Vanounou, S, Wong, D, Cheng, SD, MacNeil, J, Martin, S, Dumitra, A, Kouyoumdjian, S, Schmid, J, Spicer, A, Agarwal, A, Brar, J, Dada, A, Dare, U, Hameed, F, Osman, B, Johnston, C, Russell, G, Groot, A, Persad, H, Pham, M, Wood, M, Ko, L, Rajendran, S, Demyttenaere, R, Garfinkle, C, Brown, A, Karimuddin, N, Lee, J, Liu, Kia T, Madani, Phang, P.T., M, Raval, K, Tom, Abou-Khalil, J., A, Martel, C, Nessim, J, Stevenson, Riyami S, Al, K, Bali, D, Bigam, K, Dajani, A, Dell, MM, Modolo, Nieto P, Ramirez, R, Sepulveda, A, Molero, A, Bolbaran, I, Ruiz, F, Heredia, F, Bellolio, N, Besser, E, Grasset, JO, Guaman, M, Inzunza, MJ, Irarrázaval, C, Jarry, Martinic M, Quintana, Altamirano C, Riquoir, Manqui CA, Romero, Esquide M, Ruiz, Añazco C, Vargas, A, Almeciga, A, Fletcher, A, Merchan, T, Quijano, D, Sanabria, Arias-Amézquita, F., C, Cétares, Murgueitio N, Cortes, Gomez-Mayorga, J.L., Herrera-Almario, G., J, Rodriguez, P, Iglesias, LO, Puentes, JA, Calvache, Orozco-Chamorro, C.M., DA, Rojas, Sánchez-Gómez, A., M, Abadia, J, Acosta, Aristizabal J, Angel, A, Bonilla, L, Caicedo, Quiroz PH, Calderon, Bonilla S, Cervera, S, Diaz, H, Facundo, Mora M, Garcia, O, Guevara, L, Guzman, Mora DR, Herrera, Ramirez LJ, Jimenez, C, Lehmann, E, Manrique, I, Mariño, M, Medina, Morales RE, Pinilla, A, Puerto, Horta J, Puerto, M, Quintero, Ferro M, Rey, A, Saénz, D, Santana, W, Serrano, O, Suescun, Sanchez LM, Trujillo, Cuasquen BG, Velasquez, Quevedo J , Bogota, Mendoza, G, Bačić, D, Karlović, D, Kršul, M, Zelić, I, Luksic, M, Mamic, I, Bacic, B, Bakmaz, I, Ćoza, E, Dijan, Z, Katusic, J, Mihanovic, D, Morović, I, Rakvin, H, Almezghwi, K, Arslan, H, Besim, A, Özant, N, Özçay, K, Frantzeskou, N, Gouvas, G, Kokkinos, P, Papatheodorou, I, Pozotou, O, Stavrinidou, A, Yiallourou, L, Martinek, M, Skrovina, M, Straka, I, Szubota, M, Peteja, J, Žatecký, V, Javurkova, J, Klat, S, Antony, T, Avlund, KD, Berg, M, Borre, P, Christensen, MC, Elkjær, A, Ernst, SK, Fensman, M, Haldrup, JL, Harbjerg, LH, Iversen, Jensen, P.T., TD, Jeppesen, DW, Kjaer, HØ, Kristensen, N, Lund, Axelsen S, Maigaard, M, Mekhael, N, Mikic, EB, Ostenfeld, AL, Ebbehøj, P, Krarup, N, Schlesinger, H, Smith, S, Batista, A, Crespo, PJ, Díaz, R, Rivas, Rodriguez-Abreu, J., N, Tactuk, Kassas M, El, W, Omar, A, Tawheed, M, Talaat, A, Abdelsamed, AY, Azzam, H, Salem, A, Seleim, A, Abdelmajeed, M, Abdou, NE, Abosamak, Sayed M, A.L., F, Ashoush, R, Atta, E, Elazzazy, M, Elnemr, Hewalla ME, Elsayed, I, Elsherbini, E, Essam, M, Ewedah, I, Ghallab, E, Hassan, M, Ibrahim, M, Metwalli, M, Mourad, Qatora, M.S., M, Ragab, A, Sabry, H, Saifeldin, A, Samih, Abdelaal A, Samir, S, Shehata, K, Shenit, D, Attia, N, Kamal, N, Osman, Abbas, A.M., Elazeem HAS, Abd, Abd-Elkariem, A.Y., MM, Abdelkarem, S, Alaa, M, Ashraf, A, Ayman, MG, Azizeldine, H, Elkhayat, Mashhour A, Emad, M, Gaber, HM, Hamza, I, Hawal, HF, Hetta, Ali A, K., S, M.elghazaly, MM, Mohammed, FA, Monib, Nageh, M.A., A, Saad, MM, Saad, M, Shahine, EA, Yousof, A, Youssef, El-Deeb, M., M, Fawzy, G, Ghaly, M, Ibraheem, A, Eldaly, E, Esmail, M, ElFiky, A, Nabil, M, Alrahawy, A, Sakr, H, Soliman, H, Soltan, G, Amira, I, Sallam, M, Sherief, A, Sherif, A, Abdelrahman, H, Aboulkassem, R, Hamdy, A, Morsi, G, Sherif, H, Abdeldayem, Salama I, Abdelkader, M, Balabel, Y, Fayed, AE, Sherif, R, Elmorsi, S, Emile, B, Refky, S, Abd-elsalam, H, Badr, M, Elbahnasawy, M, Elzoghby, M, Essa, Badr S, Gamal, A, Ghoneim, O, Hamad, M, Hamada, M, Hammad, A, Hawila, Morsy, M.S., S, Salman, S, Sarsik, K, Bekele, JH, Kauppila, E, Sarjanoja, O, Helminen, H, Huhta, C, Beyrne, L, Jouffret, L, Lugans, Marie-Macron, L., E, Chouillard, Simone B, De, F, Fredon, A, Roux, J, Bettoni, S, Dakpé, B, Devauchelle, N, Lavagen, S, Testelin, S, Boucher, R, Breheret, A, Gueutier, A, Kahn, Kün-Darbois, J., A, Barrabe, Z, Lakkis, A, Louvrier, S, Manfredelli, P, Mathieu, A, Chebaro, V, Drubay, M, El amrani, C, Eveno, K, Lecolle, G, Legault, L, Martin, G, Piessen, FR, Pruvot, S, Truant, P, Zerbib, Q, Ballouhey, B, Barrat, L, Fourcade, J, Laloze, H, Salle, A, Taibi, J, Tricard, J, Usseglio, D, Bergeat, A, Merdrignac, Roy B, Le, LO, Perotto, A, Scalabre, H, Gornes, C, Vaysse, K, Vergriete, A, Aimé, A, Ezanno, B, Malgras, AP, Arnaud, E, Fustec, V, Lavoue, C, Tesson, P, Bouche, S, Tzedakis, E, Cotte, O, Glehen, J, Lifante, L, Bendjemar, H, Braham, L, Charre, Arbi N, El, L, Morel-chevillet, A, Police, V, Villefranque, E, Volpin, A, D’Urso, E, Felli, D, Mutter, P, Pessaux, B, Seeliger, Y, Barbé, J, Bardet, E, Barret, R, Berry, G, Boddaert, S, Bonnet, E, Brian, N, Cathala, X, Cathelineau, C, Denet, D, Fuks, D, Gossot, M, Grigoroiu, A, Laforest, Levy-Zauberman, Y., Louis-Sylvestre, C., P, Macek, A, Mombet, A, Moumen, G, Pourcher, F, Rozet, Salas R, Sanchez, A, Seguin-givelet, E, Tribillon, V, Crenn, Vergie S, De, E, Duchalais, F, Espitalier, C, Ferron, H, Fragnaud, O, Malard, N, Regenet, J, Rigaud, Y, Varenne, D, Waast, U, Bork, M, Distler, J, Fritzmann, J, Kirchberg, C, Praetorius, C, Riediger, J, Weitz, T, Welsch, P, Wimberger, K, Beyer, C, Kamphues, J, Lauscher, FN, Loch, C, Schineis, M, Albertsmeier, M, Angele, A, Kappenberger, H, Niess, T, Schiergens, J, Werner, R, Becker, J, Jonescheit, J, Doerner, R, Seiberth, I, Pergolini, D, Reim, J, Herzberg, H, Honarpisheh, T, Strate, C, Boeker, I, Hakami, J, Mall, 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Minicozzi, L, Navaratne, P, Patki, R, Rahman, R, Ramamoorthy, C, Sohrabi, C, Tanabalan, M, Thaha, B, Thakur, M, Venn, V, Yip, R, Baumber, J, Parry, S, Evans, L, Jeys, G, Morris, M, Parry, N, Ahmadi, G, Aresu, Barrett-Brown, Z.M., A, Coonar, Yates H, Durio, D, Gearon, J, Hogan, M, King, A, Peryt, IS, Pradeep, M, Adishesh, R, Atherton, K, Baxter, M, Brocklehurst, M, Chaudhury, N, Krishnamohan, J, McAleer, G, Owens, E, Parkin, P, Patkar, I, Phang, A, Aladeojebi, M, Ali, B, Barmayehvar, A, Gaunt, M, Gowda, E, Halliday, M, Kitchen, F, Mansour, P, Nanjaiah, D, Zakai, Abbassi-Ghadi, N., H, Assalaarachchi, A, Currie, M, Flavin, A, Frampton, M, Hague, C, Hammer, J, Hopper, J, Horsnell, S, Humphries, A, Kamocka, TK, Madhuri, S, Preston, P, Singh, J, Stebbing, A, Tailor, D, Walker, E, Coomber, S, Jaunoo, L, Kennedy, A, Airey, J, Bunni, R, Crowley, K, Fairhurst, J, Frost, R, George, S, Lee, S, Mitchell, J, Phull, S, Richards, F, Aljanadi, A, Campbell, A, Glass, I, Hraishawi, M, Jones, C, McIlmunn, S, McIntosh, P, Mhandu, C, O’Donnell, R, Turkington, Al-Ishaq, Z., S, Bhasin, AS, Bodla, A, Burahee, A, Crichton, El-Ghobashy, A., R, Fossett, N, Pigadas, E, Rahman, D, Snee, R, Vidya, N, Yassin, D, Fountain, Hasan, M.T., K, Karabatsou, R, Laurente, O, Pathmanaban, C, Barlow, D, Ding, J, Foster, L, Longstaff, Brett-Miller, C., FE, Buruiana, A, Al-mukhtar, J, Edwards, A, Giblin, C, Kelty, M, Lee, G, Lye, T, Newman, A, Sharkey, C, Steele, Shah N, Sureshkumar, E, Whitehall, J, Blair, A, Lakhiani, Parry-Smith, W., B, Sahu, R, Athwal, A, Baker, L, Jones, C, Konstantinou, S, Ramcharan, J, Vatish, R, Wilkin, A, Alzetani, K, Amer, A, Badran, HV, Colvin, M, Ethunandan, GK, Sekhon, Z, Shakoor, H, Shields, R, Singh, T, Talbot, F, Wensley, S, Lawday, A, Lyons, S, Newman, E, Chung, R, Hagger, A, Hainsworth, I, Hunt, A, Karim, H, Owen, A, Ramwell, G, Santhirakumaran, J, Smelt, C, Tan, P, Vaughan, K, Williams, C, Baker, A, Davies, J, Gossage, M, Kelly, W, Knight, S, Bromage, J, Hall, V, Kaushik, M, Rudic, N, Vallabh, Y, Zhang, G, Harris, G, James, C, Kang, DJ, Lin, AD, Rajgor, T, Royle, R, Scurrah, B, Steel, LJ, Watson, D, Choi, R, Hutchison, V, Luoma, HJ, Marcus, R, May, A, Menon, B, Pramodana, L, Webber, A, Hayes, R, Jones, G, Sivarajah, M, Smith, A, Smrke, D, Strauss, FAM, Abouelela, IA, Aneke, P, Asaad, B, Brown, J, Collis, S, Duff, A, Khan, F, Moura, M, Taylor, B, Wadham, H, Warburton, T, Elmoslemany, Jenkinson, M.D., CP, Millward, R, Zakaria, S, Mccluney, C, Parmar, S, Shah, J, Allison, Babar, M.S., J, Bowen, B, Collard, S, Goodrum, K, Lau, M, Sargent, R, Scott, E, Thomas, H, Whitmore, D, Balasubramaniam, B, Jayasankar, S, Kapoor, A, Ramachandran, C, Semple, A, Elhamshary, SMB, Imam, K, Kapriniotis, V, Kasivisvanathan, J, Lindsay, Rakhshani-Moghadam, S., N, Beech, M, Chand, L, Green, N, Kalavrezos, H, Kiconco, R, McEwen, C, Schilling, D, Sinha, J, Pereca, S, Chopra, D, Egbeare, R, Thomas, S, Arumugam, B, Ibrahim, K, Khan, T, Combellack, G, Hill, S, Jones, M, Kornaszewska, M, Mohammed, G, Tahhan, V, Valtzoglou, N, Blencowe, P, Eskander, K, Gash, L, Gourbault, M, Hanna, TA, Maccabe, B, Main, J, Olivier, C, Newton, S, Roswadowski, N, Ryan, E, Teh, D, West, H, Al-omishy, M, Baig, H, Bates, Taranto G, Di, K, Dickson, N, Dunne, C, Gill, D, Howe, D, Jeevan, A, Khajuria, Martin-Ucar, A., K, McEvoy, P, Naredla, S, Robertson, M, Sait, DR, Sarma, S, Shanbhag, T, Shortland, S, Simmonds, J, Skillman, N, Tewari, G, Walton, Akhtar, M.A., A, Brunt, J, McIntyre, K, Milne, MM, Rashid, A, Sgrò, KE, Stewart, A, Turnbull, Abou-Foul, A.K., G, Gossedge, S, O’Donnell, F, Oldfield, S, Thomson, Gonzalez M, Aguilar, S, Talukder, C, Boyle, D, Fernando, K, Gallagher, A, Laird, D, Tham, M, Bath, P, Basnyat, H, Davis, P, Montauban, A, Shrestha, K, Agarwal, T, Arif, C, Magee, T, Nambirajan, S, Powell, R, Vinayagam, I, Flindall, A, Hanson, V, Mahendran, S, Green, M, Lim, L, MacDonald, V, Miu, L, Onos, K, Sheridan, R, Young, F, Alam, O, Griffiths, C, Houlden, VS, Kolli, AK, Lala, S, Leeson, R, Peevor, Z, Seymour, E, Consorti, R, Gonzalez, R, Grolman, Kwan-Feinberg, R., T, Liu, O, Merzlikin, Francisco, San, A, Brown, Z, Cooper, S, Hirji, J, Jolissaint, D, Mahvi, B, Okafor, CP, Raut, V, Roxo, A, Salim, S, Bessen, L, Chen, L, Dagrosa, K, Fay, C, Fleischer, R, Hasson, E, Henderson, M, Leech, A, Loehrer, C, Markey, J, Paydarfar, K, Rosenkranz, K, Telma, N, Tocci, Wilkinson-Ryan, I., M, Bokenkamp, K, Brown, D, Fleming, C, Heron, C, Hill, H, Kay, E, Leede, K, McElhinney, KA, Olson, EC, Osterberg, C, Riley, P, Srikanth, J, Barbour, D, Blazer, GA, DiLalla, O, Fayanju, ES, Hwang, R, Kahmke, H, Kazaure, A, Lazarides, W, Lee, M, Lidsky, C, Menendez, D, Moris, J, Plichta, MC, Pradhan, L, Puscas, HE, Rice, D, Rocke, L, Rosenberger, R, Scheri, Smith, B.D., Stang, M.T., L, Tolnitch, K, Turnage, J, Visgauss, FS, Walton, T, Watts, S, Zani, J, Farma, K, Cardona, MC, Russell, J, Clark, D, Kwon, N, Goel, J, Kronenfeld, B, Bigelow, E, Etchill, Gabre-Kidan, A., H, Jenny, A, Kent, MR, Ladd, C, Long, H, Malapati, A, Margalit, S, Rapaport, J, Rose, K, Stevens, L, Tsai, D, Vervoort, P, Yesantharao, A, Dehal, D, Klaristenfeld, K, Huynh, H, Kaafarani, L, Naar, M, Qadan, L, Brown, I, Ganly, JE, Mullinax, N, Alpert, C, Gillezeau, Miles DDS MD, F.A.C.S.B.A., E, Taioli, DE, Cha, E, Gleeson, C, Horn, U, Sarpel, N, Gusani, J, Hazelton, J, Maines, JS, Oh, A, Ssentongo, P, Ssentongo, A, Bhama, K, Colling, M, Najarian, M, Azam, A, Choudhry, W, Marx, Y, Abedin, G, Arzumanov, R, Chokshi, S, Gabrilovich, N, Glass, E, Kalyoussef, Parvin-Nejad, F.P., D, Roden, J, Stein, Suarez-Ligon, A., G, Tsui, K, Zhao, J, Fleming, A, Fuson, J, Gigliotti, A, Ovaitt, Y, Ying, MK, Abel, V, Andaya, K, Bigay, Boeck, M.A., H, Chern, C, Corvera, El-Sayed, I., A, Glencer, P, Ha, Hamilton, B.C.S., C, Heaton, K, Hirose, Jablons, D.M., KS, Kirkwood, LZ, Kornblith, JR, Kratz, RH, Lee, PN, Miller, EK, Nakakura, Nunez-Garcia, B., RJ, O’Donnell, D, Ozgediz, P, Park, B, Robinson, A, Sarin, B, Sheu, MG, Varma, KC, Wai, R, Wustrack, MJ, Xu, M, Zimel, D, CA) Beswick, J, Goddard, J, Manor, J, Song, Springs/Loveland, Denver/Colorado, A, Cioci, W, Pavlis, K, Rakoczy, G, Ruiz, R, Saberi, T, Fullmer, C, Gaskill, N, Gross, K, Kiong, CL, Roland, SN, Zafar, M, Abdallah, A, Abouassi, E, Aigbivbalu, M, Almasri, J, Eid, B, George, G, Kulkarni, H, Marwan, M, Mehdi, Andrés M, San, J, Sundaresan, SG, Aoun, VS, Ban, HH, Batjer, K, Bosler, J, Caruso, B, Sumer, D, Abbott, A, Acher, T, Aiken, J, Barrett, E, Foley, PB, Schwartz, AT, Hawkins, A, Maiga, NM, Ruzgar, M, Sion, S, Ullrich, J, Laufer, S, Scasso, Al-Naggar, H., Al-Shehari, M., A, Almassaudi, M, Alsayadi, R, Alsayadi, M, Nahshal, S, Shream, S, AL-Ameri, M, Aldawbali, Fotopoulou, Christina, Khan, Tabassum, Bracinik, Juraj, Glasbey, James, Abu-Rustum, Nadeem, Chiva, Luis, Fagotti, Anna, Fujiwara, Keiichi, Ghebre, Rahel, Gutelkin, Murat, Konney, Thomas O., Ng, Joseph, Pareja, Rene, Kottayasamy Seenivasagam, Rajkumar, Sehouli, Jalid, Surappa, Shylasree T.S., and Leung, Elaine
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- 2022
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6. A rare case of perivascular epithelioid cell tumor (PEComa) of the pancreas diagnosed by endoscopic ultrasound
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J. D. Ulrich, K. Specht, A. M. Schlitter, G. O. Ceyhan, M. Quante, R. M. Schmid, and C. Schlag
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
A 49-year-old woman consulted her general practitioner (GP) regarding epigastric pain that she had experienced for 2 months. Physical examination and laboratory results were unremarkable. An abdominal ultrasound indicated a solid pancreatic tumor, which was confirmed on subsequent CT and MRI. Endoscopic ultrasound (EUS) showed a well-defined heterogeneous, predominantly hypoechoic mass in the pancreatic body, so a neuroendocrine tumor (NET) was suspected. However, EUS-guided fine-needle aspiration (EUS-FNA) was performed and based on (immuno-)histochemical findings, the extremely rare diagnosis of a perivascular epithelioid cell tumor (PEComa) of the pancreas was made. Due to the malignant potential of pancreatic PEComas, laparoscopic left-sided pancreatectomy was performed. We present a case diagnosed by preoperative EUS-FNA highlighting the clinical and endosonographic features which help to distinguish it from its most important differential diagnosis, neuroendocrine tumors (NETs) of the pancreas.
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- 2020
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7. Properties of individual contrails: a compilation of observations and some comparisons
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U. Schumann, R. Baumann, D. Baumgardner, S. T. Bedka, D. P. Duda, V. Freudenthaler, J.-F. Gayet, A. J. Heymsfield, P. Minnis, M. Quante, E. Raschke, H. Schlager, M. Vázquez-Navarro, C. Voigt, and Z. Wang
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Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Mean properties of individual contrails are characterized for a wide range of jet aircraft as a function of age during their life cycle from seconds to 11.5 h (7.4–18.7 km altitude, −88 to −31 °C ambient temperature), based on a compilation of about 230 previous in situ and remote sensing measurements. The airborne, satellite, and ground-based observations encompass exhaust contrails from jet aircraft from 1972 onwards, as well as a few older data for propeller aircraft. The contrails are characterized by mean ice particle sizes and concentrations, extinction, ice water content, optical depth, geometrical depth, and contrail width. Integral contrail properties include the cross-section area and total number of ice particles, total ice water content, and total extinction (area integral of extinction) per contrail length. When known, the contrail-causing aircraft and ambient conditions are characterized. The individual datasets are briefly described, including a few new analyses performed for this study, and compiled together to form a contrail library (COLI). The data are compared with results of the Contrail Cirrus Prediction (CoCiP) model. The observations confirm that the number of ice particles in contrails is controlled by the engine exhaust and the formation process in the jet phase, with some particle losses in the wake vortex phase, followed later by weak decreases with time. Contrail cross sections grow more quickly than expected from exhaust dilution. The cross-section-integrated extinction follows an algebraic approximation. The ratio of volume to effective mean radius decreases with time. The ice water content increases with increasing temperature, similar to non-contrail cirrus, while the equivalent relative humidity over ice saturation of the contrail ice mass increases at lower temperatures in the data. Several contrails were observed in warm air above the Schmidt–Appleman threshold temperature. The emission index of ice particles, i.e., the number of ice particles formed in the young contrail per burnt fuel mass, is estimated from the measured concentrations for estimated dilution; maximum values exceed 1015 kg−1. The dependence of the data on the observation methods is discussed. We find no obvious indication for significant contributions from spurious particles resulting from shattering of ice crystals on the microphysical probes.
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- 2017
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8. A comparison of sea salt emission parameterizations in northwestern Europe using a chemistry transport model setup
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D. Neumann, V. Matthias, J. Bieser, A. Aulinger, and M. Quante
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Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Atmospheric sea salt particles affect chemical and physical processes in the atmosphere. These particles provide surface area for condensation and reaction of nitrogen, sulfur, and organic species and are a vehicle for the transport of these species. Additionally, HCl is released from sea salt. Hence, sea salt has a relevant impact on air quality, particularly in coastal regions with high anthropogenic emissions, such as the North Sea region. Therefore, the integration of sea salt emissions in modeling studies in these regions is necessary. However, it was found that sea salt concentrations are not represented with the necessary accuracy in some situations.In this study, three sea salt emission parameterizations depending on different combinations of wind speed, salinity, sea surface temperature, and wave data were implemented and compared: GO03 (Gong, 2003), SP13 (Spada et al., 2013), and OV14 (Ovadnevaite et al., 2014). The aim was to identify the parameterization that most accurately predicts the sea salt mass concentrations at different distances to the source regions. For this purpose, modeled particle sodium concentrations, sodium wet deposition, and aerosol optical depth were evaluated against measurements of these parameters. Each 2-month period in winter and summer 2008 were considered for this purpose. The shortness of these periods limits generalizability of the conclusions on other years.While the GO03 emissions yielded overestimations in the PM10 concentrations at coastal stations and underestimations of those at inland stations, OV14 emissions conversely led to underestimations at coastal stations and overestimations at inland stations. Because of the differently shaped particle size distributions of the GO03 and OV14 emission cases, the deposition velocity of the coarse particles differed between both cases which yielded this distinct behavior at inland and coastal stations. The PM10 concentrations produced by the SP13 emissions generally overestimated the measured concentrations. The sodium wet deposition was generally underestimated by the model simulations but the SP13 cases yielded the least underestimations. Because the model tends to underestimate wet deposition, this result needs to be considered critically. Measurements of the aerosol optical depth (AOD) were underestimated by all model cases in the summer and partly in winter. None of the model cases clearly improved the modeled AODs. Overall, GO03 and OV14 produced the most accurate results, but both parameterizations revealed weaknesses in some situations.
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- 2016
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9. Sensitivity of modeled atmospheric nitrogen species and nitrogen deposition to variations in sea salt emissions in the North Sea and Baltic Sea regions
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D. Neumann, V. Matthias, J. Bieser, A. Aulinger, and M. Quante
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Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Coarse sea salt particles are emitted ubiquitously from the ocean surface by wave-breaking and bubble-bursting processes. These particles impact the atmospheric chemistry by affecting the condensation of gas-phase species and, thus, indirectly the nucleation of new fine particles, particularly in regions with significant air pollution. In this study, atmospheric particle concentrations are modeled for the North Sea and Baltic Sea regions in northwestern Europe using the Community Multiscale Air Quality (CMAQ) modeling system and are compared to European Monitoring and Evaluation Programme (EMEP) measurement data. The sea salt emission module is extended by a salinity-dependent scaling of the sea salt emissions because the salinity in large parts of the Baltic Sea is very low, which leads to considerably lower sea salt mass emissions compared to other oceanic regions. The resulting improvement in predicted sea salt concentrations is assessed. The contribution of surf zone emissions is considered separately. Additionally, the impacts of sea salt particles on atmospheric nitrate and ammonium concentrations and on nitrogen deposition are evaluated. The comparisons with observational data show that sea salt concentrations are commonly overestimated at coastal stations and partly underestimated farther inland. The introduced salinity scaling improves the predicted Baltic Sea sea salt concentrations considerably. The dates of measured peak concentrations are appropriately reproduced by the model. The impact of surf zone emissions is negligible in both seas. Nevertheless, they might be relevant because surf zone emissions were cut at an upper threshold in this study. Deactivating sea salt leads to minor increases in NH3 + NH4+ and HNO3 + NO3− and a decrease in NO3− concentrations. However, the overall effect on NH3 + NH4+ and HNO3 + NO3− concentrations is smaller than the deviation from the measurements. Nitrogen wet deposition is underestimated by the model at most stations. In coastal regions, the total nitrogen deposition (wet and dry) is considerably affected by sea salt particles. Approximately 3–7 % of atmospheric nitrogen deposition into the North Sea is caused by sea salt particles. The contribution is lower in the Baltic Sea region. The stations in the EMEP network provide a solid basis for model evaluation and validation. However, for a more detailed analysis of the impact of sea salt particles on atmospheric nitrogen species, size-resolved measurements of Na+, NH4+, and NO3− are needed.
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- 2016
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10. The impact of shipping emissions on air pollution in the greater North Sea region – Part 2: Scenarios for 2030
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V. Matthias, A. Aulinger, A. Backes, J. Bieser, B. Geyer, M. Quante, and M. Zeretzke
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Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Scenarios for future shipping emissions in the North Sea have been developed in the framework of the Clean North Sea Shipping project. The effects of changing NOx and SO2 emissions were investigated with the CMAQ chemistry transport model for the year 2030 in the North Sea area. It has been found that, compared to today, the contribution of shipping to the NO2 and O3 concentrations will increase due to the expected enhanced traffic by more than 20 and 5 %, respectively, by 2030 if no regulation for further emission reductions is implemented in the North Sea area. PM2.5 will decrease slightly because the sulfur contents in ship fuels will be reduced as international regulations foresee. The effects differ largely between regions, seasons and date of the implementation of stricter regulations for NOx emissions from newly built ships.
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- 2016
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11. The impact of shipping emissions on air pollution in the greater North Sea region – Part 1: Current emissions and concentrations
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A. Aulinger, V. Matthias, M. Zeretzke, J. Bieser, M. Quante, and A. Backes
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Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
The North Sea is one of the areas with the highest ship traffic densities worldwide. At any time, about 3000 ships are sailing its waterways. Previous scientific publications have shown that ships contribute significantly to atmospheric concentrations of NOx, particulate matter and ozone. Especially in the case of particulate matter and ozone, this influence can even be seen in regions far away from the main shipping routes. In order to quantify the effects of North Sea shipping on air quality in its bordering states, it is essential to determine the emissions from shipping as accurately as possible. Within Interreg IVb project Clean North Sea Shipping (CNSS), a bottom-up approach was developed and used to thoroughly compile such an emission inventory for 2011 that served as the base year for the current emission situation. The innovative aspect of this approach was to use load-dependent functions to calculate emissions from the ships' current activities instead of averaged emission factors for the entire range of the engine loads. These functions were applied to ship activities that were derived from hourly records of Automatic Identification System signals together with a database containing the engine characteristics of the vessels that traveled the North Sea in 2011. The emission model yielded ship emissions among others of NOx and SO2 at high temporal and spatial resolution that were subsequently used in a chemistry transport model in order to simulate the impact of the emissions on pollutant concentration levels. The total emissions of nitrogen reached 540 Gg and those of sulfur oxides 123 Gg within the North Sea – including the adjacent western part of the Baltic Sea until 5° W. This was about twice as much of those of a medium-sized industrialized European state like the Netherlands. The relative contribution of ships to, for example, NO2 concentration levels ashore close to the sea can reach up to 25 % in summer and 15 % in winter. Some hundred kilometers away from the sea, the contribution was about 6 % in summer and 4 % in winter. The relative contribution of the secondary pollutant NO3− was found to reach 20 % in summer and 6 % in winter even far from the shore.
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- 2016
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12. Analysis of the effect of abiotic stressors on BVOC emissions from urban green infrastructure in northern Germany
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J. Feldner, M. O. P. Ramacher, M. Karl, M. Quante, and M. L. Luttkus
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Chemistry (miscellaneous) ,Environmental Chemistry ,Pollution ,Analytical Chemistry - Abstract
Many plants are well known to emit biogenic volatile organic compounds (BVOCs). Under certain conditions BVOCs strongly enhance the photochemical formation of ozone (O3) and impact the levels of atmospheric photo-oxidants. Urban environments under the influence of climate change may face an increasing risk of elevated ozone formation potentials, because abiotic stressors such as heat and drought can stimulate BVOC emissions. However, it is largely uncertain how a combination of heat episodes and reduced soil water potentials affects air quality in cities. The effect of abiotic stress on BVOC emissions and urban O3 formation was assessed for the coastal metropolitan area of Hamburg in Germany during the vegetation period of 2018, characterized by remarkable drought and heat periods. BVOC emissions were modelled using the Model of Emissions of Gases and Aerosols from Nature (MEGAN) version 3 that accounts for several abiotic stresses. Isoprene is the single VOC with the highest share (∼60%) in the BVOC emissions of the study area. Drought stress was identified as the most important abiotic stressor that modulates BVOC emissions in this area. Modelled biogenic emissions calculcated with MEGAN3 were included together with emissions of relevant anthropogenic sectors in simulations with the chemistry transport model EPISODE-CityChem to calculate ozone concentrations under a scenario of prolonged drought stress. As a major result we identified that isoprene concentrations in Hamburg were reduced by 65% (range 6% to 95%) under drought stress during the growing period compared to non-stress conditions. Reduction of isoprene concentrations due to drought stress spatially coincided with a reduction of ozone concentrations. To asses the importance of chemical reactions involved in the formation of ozone, concentrations of isoprene, methacryloyl peroxy nitrate (MPAN) and methacrolein (MACR) have been analysed. The drought stress effect on isoprene emissions led to reductions of MACR and MPAN by approximately 80% and 20%, respectively. Since a VOC limited regime is found presently for Hamburg, it is likely that further reductions in anthropogenic NOx emissions and/or increased BVOC emissions driven by extended green infrastructure and long-term temperature increases may lead to an enhanced photochemical production of ozone in Hamburg in the future.
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- 2022
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13. Anterior Lumbar Interbody Fusion (ALIF) or Transforaminal Lumbar Interbody Fusion (TLIF) for Fusion Surgery in L5/S1 – What Is the Best Way to Restore a physiological Alignment?
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Ferenc Pécsi, Nina Bürger, Björn Thomsen, H. Halm, M. Quante, Mark Köszegvary, Clara Berlin, and Uwe Platz
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Fusion surgery ,medicine.medical_specialty ,Lumbar Vertebrae ,Lordosis ,business.industry ,medicine.medical_treatment ,Dural tear ,medicine.disease ,Single Center ,Surgery ,Cohort Studies ,Spinal Fusion ,Blood loss ,Lumbar interbody fusion ,Spinal fusion ,medicine ,Humans ,Operation time ,Orthopedics and Sports Medicine ,Prospective Studies ,business ,Retrospective Studies - Abstract
A retrospective single center cohort study with prospective collected data from an institutional spine registry.To determine whether restoration of lordosis L5/S1 is possible with both anterior lumbar interbody fusion (ALIF) and transforaminal lumbar interbody fusion (TLIF) and to find out which technique is superior to recreate lordosis in L5/S1.Seventy-seven patients with ALIF and seventy-nine with TLIF L5/S1 were included. Operation time, estimated blood loss), and complications were evaluated. Segmental lordosis L5/S1 and L4/5, overall lordosis, and proximal lordosis (L1 to L4) were measured in X-rays before and after surgery. Oswesery disability index and EQ-5D were assessed before surgery, and 3 and 12 months after surgery.Mean operation time was 176.9 minutes for ALIF and 195.7 minutes for TLIF (p = 0.048). Estimated blood loss was 249.2 cc for ALIF and 362.9 cc for TLIF (p = 0.005). In terms of complications, only a difference in dural tears were found (TLIF 6, ALIF none; p = 0.014). Lordosis L5/S1 increased in the ALIF group (15.8 to 24.6°; p 0.001), whereas no difference was noted in the TLIF group (18.4 to 19.4°; p = 0.360). Clinical results showed significant improvement in the Oswesery disability index (ALIF: 43 to 21.9, TLIF: 45.2 to 23.0) and EQ-5D (ALIF: 0.494 to 0.732, TLIF: 0.393 to 0.764) after 12 months in both groups, without differences between the groups.ALIF and TLIF are comparable methods for performing fusion at L5/S1, with good clinical outcomes and comparable rates of complications. However, there is only a limited potential for recreating lordosis at L5/S1 with a TLIF.Eine retrospektive Single-Center-Kohortenstudie mit prospektiv erhobenen Daten eines institutionellen Wirbelsäulenregisters.Es wurde untersucht, ob eine Wiederherstellung der Lordose L5/S1 sowohl mit ALIF als auch mit TLIF möglich ist und welche Technik zur Wiederherstellung der Lordose bei L5/S1 überlegen ist.77 Patienten mit ALIF und 79 mit TLIF L5/S1 wurden eingeschlossen. Operationszeit (OT), geschätzter Blutverlust (EBL) und Komplikationen wurden ausgewertet. Die segmentale Lordose L5/S1 und L4/5, die Gesamtlordose (LL) und die proximale Lordose (L1 bis L4) wurden in Röntgenbildern vor und nach der Operation ermittelt. Oswesery disability index (ODI) und EQ 5D wurden vor der Operation, 3 und 12 Monate nach der Operation ausgewertet.Die mittlere OT betrug 176,9 min für ALIF und 195,7 min für TLIF (p = 0,048). Die EBL betrug 249,2cc für ALIF und 362,9 cc für TLIF (p = 0,005). In Bezug auf Komplikationen wurde nur ein Unterschied bei den Duraläsionen gefunden (TLIF 6, ALIF keine, p = 0,014). Die Lordose L5/S1 nahm in der ALIF-Gruppe postoperativ zu (15,8 bis 24,6°, p 0,001), während in der TLIF-Gruppe kein signifikanter Unterschied festgestellt wurde (18,4° bis 19,4°, p = 0,360). Die klinischen Ergebnisse zeigten eine signifikante Verbesserung des ODI (ALIF: 43 auf 21,9, TLIF: 45,2 auf 23,0) und des EQ 5D (ALIF: 0,494 auf 0,732, TLIF: 0,393 auf 0,764) nach 12 Monaten in beiden Gruppen, ohne Unterschiede zwischen den Gruppen.Sowohl ALIF als auch TLIF sind vergleichbare Methoden zur Durchführung einer Fusion an L5/S1, mit guten klinischen Ergebnissen und vergleichbaren Komplikationsraten. Allerdings besteht bei Durchführung eines TLIF nur ein begrenztes Potenzial zur Wiederherstellung der Lordose bei L5/S1.
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- 2021
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14. Study protocol of the FIRE-8 (AIO-KRK/YMO-0519) trial: a prospective, randomized, open-label, multicenter phase II trial investigating the efficacy of trifluridine/tipiracil plus panitumumab versus trifluridine/tipiracil plus bevacizumab as first-line treatment in patients with metastatic colorectal cancer
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G. Sommerhäuser, A. Kurreck, S. Stintzing, V. Heinemann, L. Fischer von Weikersthal, T. Dechow, F. Kaiser, M. Karthaus, I. Schwaner, M. Fuchs, A. König, C. Roderburg, I. Hoyer, M. Quante, A. Kiani, S. Fruehauf, L. Müller, A. Reinacher-Schick, T. J. Ettrich, A. Stahler, and D. P. Modest
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Cancer Research ,Pyrrolidines ,Panitumumab ,Body Weight ,Antibodies, Monoclonal ,Angiogenesis Inhibitors ,Trifluridine ,Bevacizumab ,Clinical Trials, Phase II as Topic ,Oncology ,Antineoplastic Combined Chemotherapy Protocols ,Genetics ,Humans ,Multicenter Studies as Topic ,Fluorouracil ,Prospective Studies ,Colorectal Neoplasms ,Thymine ,Randomized Controlled Trials as Topic - Abstract
Background Initial systemic therapy for patients with metastatic colorectal cancer (mCRC) is usually based on two- or three-drug chemotherapy regimens with fluoropyrimidine (5-fluorouracil (5-FU) or capecitabine), oxaliplatin and/or irinotecan, combined with either anti-VEGF (bevacizumab) or, for RAS wild-type (WT) tumors, anti-EGFR antibodies (panitumumab or cetuximab). Recommendations for patients who are not eligible for intensive combination therapies are limited and include fluoropyrimidine plus bevacizumab or single agent anti-EGFR antibody treatment. The use of a monochemotherapy concept of trifluridine/ tipiracil in combination with monoclonal antibodies is not approved for first-line therapy, yet. Results from the phase II TASCO trial evaluating trifluridine/ tipiracil plus bevacicumab in first-line treatment of mCRC patients and from the phase I/II APOLLON trial investigating trifluridine/ tipiracil plus panitumumab in pre-treated mCRC patients suggest favourable activity and tolerability of these new therapeutic approaches. Methods FIRE-8 (NCT05007132) is a prospective, randomized, open-label, multicenter phase II study which aims to evaluate the efficacy of first-line treatment with trifluridine/tipiracil (35 mg/m2 body surface area (BSA), orally twice daily on days 1–5 and 8–12, q28 days) plus either the anti-EGFR antibody panitumumab (6 mg/kg body weight, intravenously on day 1 and 15, q28 days) [arm A] or (as control arm) the anti-VEGF antibody bevacizumab (5 mg/kg body weight, intravenously on day 1 and 15, q28 days) [arm B] in RAS WT mCRC patients. The primary objective is to demonstrate an improved objective response rate (ORR) according to RECIST 1.1 from 30% (control arm) to 55% with panitumumab. With a power of 80% and a two-sided significance level of 0.05, 138 evaluable patients are needed. Given an estimated drop-out rate of 10%, 153 patients will be enrolled. Discussion To the best of our knowledge, this is the first phase II trial to evaluate the efficacy of trifluridine/tipiracil plus panitumumab in first-line treatment of RAS WT mCRC patients. The administration of anti-EGFR antibodies rather than anti-VEGF antibodies in combination with trifluridine/tipiracil may result in an increased initial efficacy. Trial registration EU Clinical Trials Register (EudraCT) 2019-004223-20. Registered October 22, 2019, ClinicalTrials.govNCT05007132. Registered on August 12, 2021.
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- 2022
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15. A step in the right direction: the effect of context, strain and sex on paw preference in mice
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Binia Stieger, Luca Melotti, Sophia M. Quante, Norbert Sachser, S. Helene Richter, and Sylvia Kaiser
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0106 biological sciences ,medicine.medical_specialty ,05 social sciences ,Context (language use) ,Audiology ,Affect (psychology) ,010603 evolutionary biology ,01 natural sciences ,Preference ,Lateralization of brain function ,Action (philosophy) ,Climbing ,Laterality ,medicine ,0501 psychology and cognitive sciences ,Animal Science and Zoology ,050102 behavioral science & comparative psychology ,Psychology ,Association (psychology) ,Ecology, Evolution, Behavior and Systematics - Abstract
Behavioural lateralization is a widespread phenomenon in the animal kingdom and can be an indicator of brain asymmetries in structure or function. It is often assessed using only one measure within the same study. Additionally, this measure is usually obtained in artificial situations, where the subjects undergo tasks requiring learning and forced performance of a specific action. Combining different measures of lateralization seems to be particularly promising, as artificially tested and spontaneously displayed behaviours may cover different aspects of behavioural lateralization. Therefore, the aim of the present study was to provide a comprehensive characterization of behavioural lateralization, using the laboratory mouse, Mus musculus f. domestica, as a model system. We examined lateralization using four behavioural measures, namely food reaching in an artificial test situation (the reference, most established, test) and three spontaneous behaviours (grid climbing, self-grooming and barrier crossing). We investigated their temporal consistency, assessed the association of the three spontaneous behaviours with the established food-reaching test and explored possible influences of genetic background and sex. We found differences in the distributions of lateralization across these behaviours, with fewer mice showing laterality in spontaneous behaviours. All behaviours showed high temporal consistency for the direction of laterality, while only food reaching did so for the strength of laterality. Furthermore, laterality of the spontaneous behaviours was unrelated to laterality of the food-reaching test. Lastly, strain affected behavioural lateralization, with C57BL/6J mice being more strongly lateralized than CD-1 mice for some behaviours, while sex did not affect it. Therefore, we conclude that behavioural lateralization is affected not only by genetic background, but also by the complexity of a given task. To obtain a comprehensive picture of behavioural lateralization, several measures from different contexts thus need to be included in a single study.
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- 2021
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16. Erhobene Daten zur Instrumentierung in Freihandtechnik und Literaturvergleich zu fluoroskopisch- und CT-gestützter Navigation
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U. Platz, M. Quante, C. Berlin, H. Halm, M. Köszegvary, and B. Thomsen
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Gynecology ,030222 orthopedics ,medicine.medical_specialty ,business.industry ,Idiopathic scoliosis ,Radiation exposure ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,Orthopedics and Sports Medicine ,business ,Pedicle screw ,Intraoperative imaging ,030217 neurology & neurosurgery - Abstract
Eine bewahrte und haufig angewandte Operation bei Patienten (Pat) mit idiopathischer Skoliose (IS) ist die dorsale transpedikulare Korrekturspondylodese in Freihandtechnik. Neuere Verfahren mit fluoroskopisch- und CT-gestutzter Navigation sind mutmaslich risikoarmer und exakter. Ist die Freihandtechnik bei IS bezuglich der schraubenassoziierten Komplikationen und intraoperativen Strahlenbelastung sicher? Anhand prospektiv erfasster Daten (2017–2018) von 39 konsekutiven Pat (durchschn. Alter 18,7 J.) mit thorakal einbogiger IS (61,7° ±13,9) eines Skoliosezentrums wurden folgende Parameter (Mittelwert ± Standardabweichung) ausgewertet: Gesamtstrahlenprodukt, Durchleuchtungszeit, fusionierte Segmente, Operationszeit, Blutverlust und schraubenassoziierte Komplikation. Es erfolgte ein Literaturvergleich mit Daten zur intraoperativen Strahlenbelastung bei Navigationsverfahren. Das Gesamtstrahlenprodukt/Pat betrug 71,7 ± 44,0 cGy * cm2, die Durchleuchtungszeit 17,4 ± 8,6 s (7,8 Segmente), die Operationszeit 183,5 ± 54,2 min und der Blutverlust 379,5 ± 183 ml. Keine schraubenassoziierte Komplikation im gesamten Kollektiv. Die Korrektur der Hauptkrummung betrug 75,7 %. Der Vergleich der erhobenen Daten mit denen aus der Literatur zeigte eine fur den Pat 1,25- bis 12,5-fach hohere Strahlenexposition bei fluoroskopisch- gestutzter Navigation und 9,25- bis 12,3-fach hohere bei CT-gestutzten Verfahren. Freihandiges Setzen von Pedikelschrauben ist bei entsprechender Erfahrung mit vergleichbarer Genauigkeit und geringerer Strahlenbelastung fur den Pat verbunden als navigierende Verfahren. Hinsichtlich des geringen Alters der Pat sollte ein strahleninduziertes Langzeitrisiko fur maligne Erkrankungen berucksichtigt werden.
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- 2020
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17. GEWEX Cloud System Study (GCSS) cirrus cloud working group: development of an observation-based case study for model evaluation
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H. Yang, S. Dobbie, G. G. Mace, A. Ross, and M. Quante
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Geology ,QE1-996.5 - Abstract
The GCSS working group on cirrus focuses on an inter-comparison of model simulations ranging from very detailed microphysical and dynamical models through to general circulation models (GCMs). The past GCSS cirrus cloud inter-comparison highlighted the wide range in modelling results that was a surprise to the modelling community. That inter-comparison was idealised and, therefore, a key issue was that it did not benefit from observations to help distinguish between model performances. In this work, we aim to address this key issue by developing an observationally based case study to be used for the GCSS cirrus modelling inter-comparison study. We focused on developing a case that had sufficient observations with which to evaluate models, to help identify which models in the inter-comparison are performing well and highlight areas for model development. Furthermore, it will provide a base case for future model comparisons or testing of new or updated models. This paper outlines the modelling case development and the inter-comparison results will be presented in a follow-on paper. The case was based on the 9 March 2000 Atmospheric Radiation Measurement (ARM) Southern Great Plains (SGP) during an intensive observation period (IOP). The case was developed utilising various observations including ARM SGP remote sensing including the MilliMeter Cloud Radar (MMCR), radiometers, radiosondes, aircraft observations, satellite observations, objective analysis and complemented with results from the Rapid Update Cycle (RUC) model as well as bespoke gravity wave simulations used to provide the best estimate for large scale forcing. The retrievals of ice water content, ice number concentration and fall velocity provide several constraints to evaluate model performances. Initial testing of the case has been reported using the UK Met Office Large Eddy Simulation Model (LEM) which suggests the case is appropriate for the model inter-comparison study. To our knowledge, this case offers the most detailed case study for cirrus comparison available and we anticipate this will offer significant benefits over past comparisons which have mostly been loosely based on observations.
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- 2012
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18. Adapting CMAQ to investigate air pollution in North Sea coastal regions.
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Volker Matthias, A. Aulinger, and M. Quante
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- 2008
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19. SMOKE for Europe – adaptation, modification and evaluation of a comprehensive emission model for Europe
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J. Bieser, A. Aulinger, V. Matthias, M. Quante, and P. Builtjes
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Geology ,QE1-996.5 - Abstract
The US EPA regional emission model SMOKE was adopted and modified to create temporally and spatially distributed emission for Europe and surrounding countries based on official reports and public domain data only. The aim is to develop a flexible model capable of creating consistent high resolution emission data for long-term runs of Chemical Transport Models (CTMs). This modified version of SMOKE, called SMOKE for EUROPE (SMOKE-EU) was successfully used to create hourly gridded emissions for the timespan 1970–2010. In this paper the SMOKE-EU model and the underlying European datasets are introduced. Emission data created by SMOKE-EU for the year 2000 are evaluated by comparison to data of three different state-of-the-art emission models. SMOKE-EU produced a range of values comparable to the other three datasets. Further, concentrations of criteria pollutants calculated by the CTM CMAQ using the four different emission datasets were compared against EMEP measurements with hourly and daily resolution. Using SMOKE-EU gave the most reliable modelling of O3, NO2 and SO42−. The amount of simulated concentrations within a factor of 2 (F2) of the observations for these species are: O3 (F2 = 0.79, N = 329 197), NO2 (F2 = 0.55, N = 11 465) and SO42− (F2 = 0.62, N = 17 536). The lowest values were found for NH4+ (F2 = 0.34, N = 7400) and NO3− (F2 = 0.25, N = 6184). NH4+ concentrations were generally overestimated, leading to a fractional bias (FB) averaged over 22 measurement stations of (FB = 0.83 ± 0.41) while better agreements with observations were found for SO42− (FB = 0.06 ± 0.38, 51 stations) and NO3− (FB = 0.13 ± 0.75, 18 stations). CMAQ simulations using the three other emission datasets were similar to those modelled using SMOKE-EU emissions. Highest differences where found for NH4+ while O3 concentrations were almost identical.
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- 2011
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20. Single trial fMRI reveals significant contralateral bias in responses to laser pain within thalamus and somatosensory cortices.
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Ulrike Bingel, M. Quante, René Knab, B. Bromm, Cornelius Weiller, and Christian Büchel
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- 2003
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21. Vasoactive intestinal peptide modulates intestinal stem cell activity and differentiation
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IE Demir, Roland M. Schmid, Moritz Middelhoff, Dieter Saur, M Quante, J Wieland, and T Agibalova
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Chemistry ,Vasoactive intestinal peptide ,Stem cell ,Cell biology - Published
- 2021
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22. Characterization of the cholinergic stem cell niche in the murine colon
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M Quante, B Kohnke-Ertel, J Wieland, AM Bührer, IE Demir, T Agibalova, Roland M. Schmid, and Moritz Middelhoff
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Cholinergic ,Biology ,Stem cell niche ,Cell biology - Published
- 2021
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23. Erfolgreiche primäre endoskopische Unterdrucktherapie bei spontan-perforierten Duodenaldivertikeln
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D Stüker, U Schweizer, D Wichmann, M Quante, and A Königsrainer
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- 2021
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24. Die Rolle der Magnifikationsendoskopie für Surveillance innerhalb des ersten Jahres nach Dünndarm-Transplantation
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M Quante, A Königsrainer, D Wichmann, and D Stüker
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- 2021
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25. Pathophysiologie des Adenokarzinoms am ösophagogastralen Übergang (AEG)
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L. Liotta and M. Quante
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0301 basic medicine ,Gynecology ,03 medical and health sciences ,medicine.medical_specialty ,030104 developmental biology ,0302 clinical medicine ,Oncology ,business.industry ,030220 oncology & carcinogenesis ,medicine ,Hematology ,business - Abstract
Der Barrett-Osophagus wird als entscheidende Ursprungslasion fur das Adenokarzinom am osophagogastralen Ubergang (AEG) angesehen. Weitgehend unklar ist allerdings nach wie vor, welche Faktoren, Einwirkungen und Ablaufe fur die Karzinogenese verantwortlich sind. In dieser Ubersichtsarbeit sollen v. a. die Bedeutung epidemiologischer, genetischer und immunologischer Faktoren sowie der Einfluss eines hierdurch teilweise veranderten Mikromilieus als initiierende Faktoren erortert werden. Veranderungen in Mikrobiom und Genstruktur (z. B. durch Verlust von TP53 und p16) konnen eine Nische von Stammzellen am osophagogastralen Ubergang (die z. B. in Mausen LGR5, CCK2R und CAR4 exprimieren) bilden, in der vermehrte Zellteilung sowie eine maligne Entartung begunstigt wird. Dabei konnten spezifische Stammzellen, die wahrscheinlich aus Drusen im Bereich der Kardia im Magen entstehen − als Ursprung fur die maligne Transformation sowie in Abhangigkeit von ihrem Differenzierungspotenzial fur die Tumorentstehung ausschlaggebend sein. Aktuelle Studien deuten darauf hin, dass das metaplastische Epithel nicht im Osophagus, sondern in der Kardia entsteht, von wo Stammzellen (im weiteren Verlauf) in den Osophagus expandieren. Ein besseres Verstandnis dieser Mechanismen kann zu einer besseren Fruherkennung, Pravention und schlussendlich auch Therapie der AEG fuhren.
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- 2019
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26. Elective cancer surgery in COVID-19–Free surgical pathways during the SARS-cov-2 pandemic: An international, multicenter, comparative cohort study
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James C Glasbey, Dmitri Nepogodiev, Joana Ff Simoes, Omar Omar, Elizabeth Li, Mary L Venn, Mohammad Abou Chaar, Vita Capizzi, Daoud Chaudhry, Anant Desai, Jonathan G Edwards, Jonathan P Evans, Marco Fiore, Jose Flavio Videria, Samuel J Ford, Ian Ganyli, Ewen A Griffiths, Rohan R Gujjuri, Angelos G Kolias, Haytham Ma Kaafarani, Ana Minaya-Bravo, Siobhan C McKay, Helen M Mohan, Keith Roberts, Carlos San Miguel-Méndez, Peter Pockney, Richard Shaw, Neil J Smart, Grant D Stewart, Sudha Sundar, Raghavan Vidya, Aneel A Bhangu, James C Glasbey, Omar Omar, Aneel A Bhangu, Kwabena Siaw-Acheampong, Ruth A Benson, Edward Bywater, Daoud Chaudhry, Brett E Dawson, Jonathan P Evans, James C Glasbey, Rohan R Gujjuri, Emily Heritage, Conor S Jones, Sivesh K Kamarajah, Chetan Khatri, Rachel A Khaw, James M Keatley, Andrew Knight, Samuel Lawday, Elizabeth Li, Harvinder S Mann, Ella J Marson, Kenneth A McLean, Siobhan C McKay, Emily C Mills, Dmitri Nepogodiev, Gianluca Pellino, Maria Picciochi, Elliott H Taylor, Abhinav Tiwari, Joana Ff Simoes, Isobel M Trout, Mary L Venn, Richard Jw Wilkin, Aneel A Bhangu, James C Glasbey, Neil J Smart, Ana Minaya-Bravo, Jonathan P Evans, Gaetano Gallo, Susan Moug, Francesco Pata, Peter Pockney, Salomone Di Saverio, Abigail Vallance, Dale Vimalchandran, Ewen A Griffiths, Sivesh K Kamarajah, Richard Pt Evans, Philip Townend, Keith Roberts, Siobhan McKay, John Isaac, Sohei Satoi, John Edwards, Aman S Coonar, Adrian Marchbank, Edward J Caruana, Georgia R Layton, Akshay Patel, Alessandro Brunelli, Samuel Ford, Anant Desai, Alessandro Gronchi, Marco Fiore, Max Almond, Fabio Tirotta, Sinziana Dumitra, Angelos Kolias, Stephen J Price, Daniel M Fountain, Michael D Jenkinson, Peter Hutchinson, Hani J Marcus, Rory J Piper, Laura Lippa, Franco Servadei, Ignatius Esene, Christian Freyschlag, Iuri Neville, Gail Rosseau, Karl Schaller, Andreas K Demetriades, Faith Robertson, Alex Alamri, Richard Shaw, Andrew G Schache, Stuart C Winter, Michael Ho, Paul Nankivell, Juan Rey Biel, Martin Batstone, Ian Ganly, Raghavan Vidya, Alex Wilkins, Jagdeep K Singh, Dinesh Thekinkattil, Sudha Sundar, Christina Fotopoulou, Elaine Leung, Tabassum Khan, Luis Chiva, Jalid Sehouli, Anna Fagotti, Paul Cohen, Murat Gutelkin, Rahel Ghebre, Thomas Konney, Rene Pareja, Rob Bristow, Sean Dowdy, T S Shylasree, R Kottayasamy Seenivasagam, Joe Ng, Keiiji Fujiwara, Grant D Stewart, Benjamin Lamb, Krishna Narahari, Alan McNeill, Alexandra Colquhoun, John McGrath, Steve Bromage, Ravi Barod, Veeru Kasivisvanathan, Tobias Klatte, Joana Ff Simoes, Tom Ef Abbott, Sadi Abukhalaf, Michel Adamina, Adesoji O Ademuyiwa, Arnav Agarwal, Murat Akkulak, Ehab Alameer, Derek Alderson, Felix Alakaloko, Markus Albertsmeiers, Osaid Alser, Muhammad Alshaar, Sattar Alshryda, Alexis P Arnaud, Knut Magne Augestad, Faris Ayasra, José Azevedo, Brittany K Bankhead-Kendall, Emma Barlow, David Beard, Ruth A Benson, Ruth Blanco-Colino, Amanpreet Brar, Ana Minaya-Bravo, Kerry A Breen, Chris Bretherton, Igor Lima Buarque, Joshua Burke, Edward J Caruana, Mohammad Chaar, Sohini Chakrabortee, Peter Christensen, Daniel Cox, Moises Cukier, Miguel F Cunha, Giana H Davidson, Anant Desai, Salomone Di Saverio, Thomas M Drake, John G Edwards, Muhammed Elhadi, Sameh Emile, Shebani Farik, Marco Fiore, J Edward Fitzgerald, Samuel Ford, Tatiana Garmanova, Gaetano Gallo, Dhruv Ghosh, Gustavo Mendonça Ataíde Gomes, Gustavo Grecinos, Ewen A Griffiths, Madalegna GrÜndl, Constantine Halkias, Ewen M Harrison, Intisar Hisham, Peter J Hutchinson, Shelley Hwang, Arda Isik, Michael D Jenkinson, Pascal Jonker, Haytham Ma Kaafarani, Debby Keller, Angelos Kolias, Schelto Kruijff, Ismail Lawani, Hans Lederhuber, Sezai Leventoglu, Andrey Litvin, Andrew Loehrer, Markus W Löffler, Maria Aguilera Lorena, Maria Marta Modolo, Piotr Major, Janet Martin, Hassan N Mashbari, Dennis Mazingi, Symeon Metallidis, Ana Minaya-Bravo, Helen M Mohan, Rachel Moore, David Moszkowicz, Susan Moug, Joshua S Ng-Kamstra, Mayaba Maimbo, Ionut Negoi, Milagros Niquen, Faustin Ntirenganya, Maricarmen Olivos, Kacimi Oussama, Oumaima Outani, Marie Dione Parreno-Sacdalanm, Francesco Pata, Carlos Jose Perez Rivera, Thomas D Pinkney, Willemijn van der Plas, Peter Pockney, Ahmad Qureshi, Dejan Radenkovic, Antonio Ramos-De la Medina, Keith Roberts, April C Roslani, Martin Rutegård, Juan José Segura-Sampedro, Irène Santos, Sohei Satoi, Raza Sayyed, Andrew Schache, Andreas A Schnitzbauer, Justina O Seyi-Olajide, Neil Sharma, Richard Shaw, Sebastian Shu, Kjetil Soreide, Antonino Spinelli, Grant D Stewart, Malin Sund, Sudha Sundar, Stephen Tabiri, Philip Townend, Georgios Tsoulfas, Gabrielle H van Ramshorst, Raghavan Vidya, Dale Vimalachandran, Oliver J Warren, Duane Wedderburn, Naomi Wright, C Allemand, L Boccalatte, M Figari, M Lamm, J Larrañaga, C Marchitelli, F Noll, D Odetto, M Perrotta, J Saadi, L Zamora, C Alurralde, E L Caram, D Eskinazi, J P Mendoza, M Usandivaras, R Badra, A Esteban, J S García, P M García, J I Gerchunoff, S M Lucchini, M A NIgra, L Vargas, T Hovhannisyan, A Stepanyan, T Gould, R Gourlay, B Griffiths, S Gananadha, M McLaren, J Cecire, N Joshi, S Salindera, A Sutherland, J H Ahn, G Charlton, S Chen, N Gauri, R Hayhurst, S Jang, F Jia, C Mulligan, W Yang, G Ye, H Zhang, M Ballal, D Gibson, D Hayne, J Moss, T Richards, P Viswambaram, U G Vo, J Bennetts, T Bright, M Brooke-Smith, R Fong, B Gricks, Y H Lam, B S Ong, M Szpytma, D Watson, K Bagraith, S Caird, E Chan, C Dawson, D Ho, E Jeyarajan, S Jordan, A Lim, G J Nolan, A Oar, D Parker, H Puhalla, A Quennell, L Rutherford, P Townend, M Von Papen, M Wullschleger, A Blatt, D Cope, N Egoroff, M Fenton, J Gani, N Lott, P Pockney, N Shugg, M Elliott, D Phung, D Phan, D Townend, C Bong, J Gundara, A Frankel, S Bowman, G R Guerra, J Bolt, K Buddingh, N N Dudi-Venkata, S Jog, H M Kroon, T Sammour, R Smith, C Stranz, M Batstone, K Lah, W McGahan, D Mitchell, A Morton, A Pearce, M Roberts, G Sheahan, B Swinson, N Alam, S Banting, L Chong, 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C McDonald, N McGrath, N McSorley, K Ragupathy, L Ramsay, A Solth, O Kakisi, K Seebah, I Shaikh, L Sreedharan, M Youssef, J Shah, P Ameerally, N McLarty, S Mills, A Shenfine, K Sahnan, J Abu, E Addae-Boateng, D Bratt, L Brock, N Burnside, S Cadwell-Sneath, K Gajjar, C Gan, C Grundy, K Hallam, K Hassell, M Hawari, A Joshi, H Khout, K Konstantinidi, Rxn Lee, D Nunns, R Schiemer, T Walton, H Weaver, L Whisker, K Williamson, J McVeigh, R Myatt, M A Williams, R Kaur, E Leung, S Sundar, M Michel, S Patil, S Ravindran, J Sarveswaran, L Scott, M Edmond, E King, M Almond, A Bhangu, O Breik, L D Cato, A Desai, S Ford, E Griffiths, M Idle, M Kamal, A Kisiel, R Kulkarni, Jkc Mak, T Martin, P Nankivell, A Parente, S Parmar, A M Pathanki, L Phelan, P Praveen, S Saeed, N Sharma, J Singh, F Tirotta, D Vijayan, A Geddes, J McCaul, J McMahon, A H Khan, F Khan, A Mansuri, S Mukherjee, M Patel, M Sarigul, S Singh, K L Tan, A Woodham, A Adiamah, H Brewer, A Chowdhury, J Evans, D Humes, J Jackman, A Koh, C Lewis-Lloyd, O Oyende, J Reilly, D Worku, P Cool, G Cribb, K Shepherd, C Bisset, S Moug, N Elson, G Faulkner, P Saleh, C Underwood, G Brixton, L Findlay, T Klatte, A Majkowska, J Manson, R Potter, A Bhalla, Z Chia, P Daliya, A Goyal, E Grimley, A Hamad, A Kumar, F L Malcolm, E Theophilidou, J Bowden, N Campain, I Daniels, C Evans, G Fowler, J John, L Massey, F McDermott, J McGrath, A McLennan, M Ng, J Pascoe, N Rajaretnam, S Bulathsinhala, B Davidson, G Fusai, C Hidalgo Salinas, N Machairas, T Pissanou, J M Pollok, D A Raptis, F Soggiu, H Tzerbinis, S E Xyda, A Beamish, E Davies, R Foulkes, D Magowan, H Nassa, R Ooi, C Price, L Smith, F Solari, A Tang, G Williams, Y Al-Tamimi, A Bacon, N Beasley, D Chew, M Crank, N Ilenkovan, M Macdonald, B Narice, O Rominiyi, A Thompson, I Varley, T Drake, E Harrison, G Linder, J Mayes, R McGregor, R Skipworth, V Zamvar, E Davies, P Hawkin, T Raymond, O Ryska, R Baron, D Dunne, S Gahunia, C Halloran, N Howes, R McKinney, F McNicol, J Russ, P Szatmary, J R Tan, A Thomas, P Whelan, A Anzak, A Banerjee, O Fuwa, F Hughes, J D Jayasinghe, C Knowles, H Kocher, I Leal Silva, F S Ledesma, A Minicozzi, L Navaratne, R Rahman, R Ramamoorthy, C Sohrabi, M Thaha, B Thakur, M Venn, V Yip, R Baumber, J Parry, S Evans, L Jeys, G Morris, M Parry, J Stevenson, N Ahmadi, G Aresu, Z M Barrett-Brown, A S Coonar, H Durio Yates, D Gearon, J Hogan, M King, A Peryt, I S Pradeep, C Smith, M Adishesh, R Atherton, K Baxter, M Brocklehurst, M Chaudhury, N Krishnamohan, J McAleer, G Owens, E Parkin, P Patkar, I Phang, A Aladeojebi, M Ali, B Barmayehvar, A Gaunt, M Gowda, E Halliday, M Kitchen, F Mansour, M Thomas, D Zakai, N Abbassi-Ghadi, H Assalaarachchi, A Currie, M Flavin, A Frampton, M Hague, C Hammer, J Hopper, J Horsnell, S Humphries, A Kamocka, T K Madhuri, S Preston, P Singh, J Stebbing, A Tailor, D Walker, F Aljanadi, M Jones, P Mhandu, C O'Donnell, R Turkington, Z Al-Ishaq, S Bhasin, A S Bodla, A Burahee, A Crichton, R Fossett, N Pigadas, S Pickford, E Rahman, D Snee, R Vidya, N Yassin, F Colombo, D Fountain, M T Hasan, K Karabatsou, R Laurente, O Pathmanaban, A Al-Mukhtar, S Brown, J Edwards, A Giblin, C Kelty, M Lee, G Lye, T Newman, A Sharkey, C Steele, N Sureshkumar Shah, E Whitehall, R Athwal, A Baker, L Jones, C Konstantinou, S Ramcharan, S Singh, J Vatish, R Wilkin, M Ethunandan, G K Sekhon, H Shields, R Singh, F Wensley, S Lawday, A Lyons, T Abbott, S Anwar, K Ghufoor, C Sohrabi, E Chung, R Hagger, A Hainsworth, A Karim, H Owen, A Ramwell, K Williams, C Baker, A Davies, J Gossage, M Kelly, W Knight, J Hall, G Harris, G James, C Kang, D J Lin, A D Rajgor, T Royle, R Scurrah, B Steel, L J Watson, D Choi, R Hutchison, A Jain, V Luoma, H Marcus, R May, A Menon, B Pramodana, L Webber, I A Aneke, P Asaad, B Brown, J Collis, S Duff, A Khan, F Moura, B Wadham, H Warburton, T Elmoslemany, M Jenkinson, C Millward, R Zakaria, S Mccluney, C Parmar, S Shah, J Allison, M S Babar, B Collard, S Goodrum, K Lau, A Patel, R Scott, E Thomas, H Whitmore, D Balasubramaniam, B Jayasankar, S Kapoor, A Ramachandran, A Elhamshary, Smb Imam, K Kapriniotis, V Kasivisvanathan, J Lindsay, S Rakhshani-Moghadam, N Beech, M Chand, L Green, N Kalavrezos, H Kiconco, R McEwen, C Schilling, D Sinha, J Pereca, J Singh, S Chopra, D Egbeare, R Thomas, T Combellack, Sef Jones, M Kornaszewska, M Mohammed, A Sharma, G Tahhan, V Valtzoglou, J Williams, P Eskander, K Gash, L Gourbault, M Hanna, T Maccabe, C Newton, J Olivier, S Rozwadowski, E Teh, D West, H Al-Omishy, M Baig, H Bates, G Di Taranto, K Dickson, N Dunne, C Gill, D Howe, D Jeevan, A Khajuria, K Martin-Ucar AMcEvoy, P Naredla, V Ng, S Robertson, M Sait, D R Sarma, S Shanbhag, T Shortland, S Simmonds, J Skillman, N Tewari, G Walton, M A Akhtar, A Brunt, J McIntyre, K Milne, M M Rashid, A Sgro, K E Stewart, A Turnbull, M Aguilar Gonzalez, S Talukder, C Boyle, D Fernando, K Gallagher, A Laird, D Tham, M Bath, P Patki, C Sohrabi, C Tanabalan, T Arif, C Magee, T Nambirajan, S Powell, R Vinayagam, I Flindall, A Hanson, V Mahendran, S Green, M Lim, L MacDonald, V Miu, L Onos, K Sheridan, R Young, F Alam, O Griffiths, C Houlden, R Jones, V S Kolli, A K Lala, S Leeson, R Peevor, Z Seymour, L Chen, E Henderson, A Loehrer, K Brown, D Fleming, A Haynes, C Heron, C Hill, H Kay, E Leede, K McElhinney, K Olson, E C Osterberg, C Riley, P Srikanth, M Thornhill, D Blazer, G DiLalla, E S Hwang, W Lee, M Lidsky, J Plichta, L Rosenberger, R Scheri, K Shah, K Turnage, J Visgauss, S Zani, J Farma, J Clark, D Kwon, E Etchill, H E Gabre-Kidan AJenny, A Kent, M Ladd, C Long, H Malapati, A Margalit, S Rapaport, J Rose, K Stevens, L Tsai, D Vervoort, P Yesantharao, A Dehal, D Klaristenfeld, K Huynh, L Brown, I Ganly, J Mullinax, N Gusani, J Hazelton, J Maines, J S Oh, A Ssentongo, P Ssentongo, M Azam, A Choudhry, W Marx, J Fleming, A Fuson, J Gigliotti, A Ovaitt, Y Ying, M K Abel, V Andaya, K Bigay, M A Boeck, L Chen, H Chern, C Corvera, I El-Sayed, A Glencer, P Ha, Bcs Hamilton, C Heaton, K Hirose, D M Jablons, K Kirkwood, L Z Kornblith, J R Kratz, R Lee, P N Miller, E Nakakura, B Nunez-Garcia, R O'Donnell, D Ozgediz, P Park, B Robinson, A Sarin, B Sheu, M Varma, K Wai, R Wustrack, M J Xu, D Beswick, J Goddard, J Manor, J Song, T Fullmer, C Gaskill, N Gross, K Kiong, C L Roland, S N Zafar, M Abdallah, A Abouassi, M Almasri, G Kulkarni, H Marwan, M Mehdi, S Aoun, V S Ban, H H Batjer, J Caruso, D Abbott, A Acher, T Aiken, J Barrett, E Foley, P Schwartz, S N Zafar, A Hawkins, A Maiga, J Laufer, S Scasso
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Aged, 80 and over ,Male ,Critical Care ,SARS-CoV-2 ,International Cooperation ,COVID-19 ,Middle Aged ,Cohort Studies ,Logistic Models ,Postoperative Complications ,Elective Surgical Procedures ,Neoplasms ,Outcome Assessment, Health Care ,Humans ,Female ,Epidemics ,Aged - Abstract
PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks.
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- 2021
27. Intraoperative Radiation Exposure for Patients with Double-Curve Idiopathic Scoliosis in Freehand-Technique in Comparison to Fluoroscopic- and CT-Based Navigation
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Mark Köszegvary, M. Quante, Björn Thomsen, Uwe Platz, H. Halm, and Clara Berlin
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Intraoperative radiation ,Idiopathic scoliosis ,Scoliosis ,03 medical and health sciences ,0302 clinical medicine ,Ct based navigation ,Pedicle Screws ,Medicine ,Fluoroscopy ,Humans ,Orthopedics and Sports Medicine ,Retrospective Studies ,030222 orthopedics ,medicine.diagnostic_test ,business.industry ,Double curve ,Lumbar Curve ,Radiation Exposure ,Neurovascular bundle ,medicine.disease ,Spinal Fusion ,Surgery ,business ,Nuclear medicine ,Tomography, X-Ray Computed ,030217 neurology & neurosurgery - Abstract
In the operative treatment of idiopathic scoliosis, posterior correction and fusion in freehand technique is a proven procedure and is frequently performed. Malpositioned pedicle screws can result in serious neurovascular complications. Intraoperative fluoroscopy and neurophysiological measurements are performed to ensure the correct position of pedicle screws. Newer procedures with fluoroscopic- and computertomographic-assisted navigation are advertised as less dangerous and with a more accurate screw position.Is the freehand technique used in the surgical treatment of idiopathic scoliosis safer than other methods with regard to complications caused by screw malposition and intraoperative radiation exposure?Register data of 34 consecutive idiopathic scoliosis patients with two structural curves (Lenke 3 and 6) were collected prospectively in our scoliosis center and were retrospectively analyzed. The following parameters were evaluated: total radiation product, time of fluoroscopy, number of fused segments, time of operation, blood loss, screw-related complications and number of instrumented pedicle screws. All values were given as mean ± standard deviation and statistically analyzed. Finally, our data were compared on accuracy of screw placement and radiation exposure to data from literature with screw placement under navigation.Average age at the time of surgery was 23.6 ± 12 years. The average thoracic curve was 69.2 ± 14.2° preoperatively and 21.7 ± 12.8° postoperatively (correction 69.9%), the average lumbar curve was 64.3° ± 10.8° preoperatively and corrected to 15.6 ± 10.4° postoperatively (correction 76.2%). The total radiation product per patient was 145.7 ± 86.1 cGy*cm², the time of fluoroscopy 31.7 ± 23.5 s (11.5 segments), the time of operation 267.2 ± 64.1 min and the blood loss 700.4 ± 522.3 ml. A total of 803 pedicle screws were placed. No screw-associated complications were detected in the entire collective. The comparison of our data with freehand placement of pedicle screws to literature data showed a noticeable higher radiation exposure for the patient during fluoroscopic- and computertomographic-assisted navigation.The results showed that positioning of pedicle screws with freehand technique in patients with idiopathic scoliosis is accompanied with considerably lower intraoperative radiation exposure compared to fluoroscopic- or computertomographic-assisted navigation. An increased radiation exposure of these typically young patients is associated with an increased long-term risk for the occurrence of radiation-induced malignant diseases. With appropriate surgical experience, placement of pedicle screws in freehand technique is safe and effective and with similar accuracy than screws placed under navigation, but produces significantly less radiation exposure to the patients.In der operativen Therapie der idiopathischen Skoliose hat sich die dorsale Korrekturspondylodese mit Pedikelschrauben-Doppelstabsystem in Freihandtechnik bewährt und wird häufig durchgeführt. Durch Fehllage der Pedikelschrauben können schwerwiegende neurovaskuläre Komplikationen resultieren. Zur Überprüfung einer korrekten Schraubenlage werden intraoperative fluoroskopische Kontrollen sowie neurophysiologische Messungen durchgeführt. Neuere Verfahren mit fluoroskopischer oder computertomografisch gestützter Navigation werden als risikoärmer und mit genauerer Schraubenlage beworben.Ist die Freihandtechnik in der operativen Behandlung der idiopathischen Skoliose in Bezug auf die Komplikationen durch Schraubenfehllage und die intraoperative Strahlenexposition im Vergleich zu anderen Verfahren sicher?Prospektiv wurden Registerdaten von 34 konsekutiven Patienten erfasst und retrospektiv analysiert, die aufgrund einer doppelbogigen idiopathischen Skoliose (Lenke 3 und 6) in unserem Skoliosezentrum operiert wurden. Folgende Parameter wurden ausgewertet: Gesamtstrahlenprodukt, Durchleuchtungszeit, Anzahl fusionierter Segmente, Operationszeit, Blutverlust, schraubenassoziierte Komplikationen und Anzahl der gesetzten Pedikelschrauben. Alle Werte wurden als Mittelwert ± Standardabweichung angegeben und statistisch ausgewertet. Es erfolgte ein Vergleich unserer Daten zur Genauigkeit der Pedikelschraubenlage und der Strahlenbelastung mit den Daten der Literatur bei navigierten Verfahren.Das Alter zum Operationszeitpunkt betrug 23,6 ± 12 Jahre. Die durchschnittliche thorakale Krümmung betrug präoperativ 69,2 ± 14,2° und postoperativ 21,7 ± 12,8° (Korrektur 69,9%), die durchschnittliche lumbale Krümmung präoperativ 64,3 ± 10,8° und postoperativ 15,6 ± 10,4° nach Cobb (Korrektur 76,2%). Das Gesamtstrahlenprodukt pro Patient betrug 145,7 ± 86,1 cGy*cm², die Durchleuchtungszeit 31,7 ± 23,5 s (11,5 Segmente), die Operationszeit 267,2 ± 64,1 min und der Blutverlust 700,4 ± 522,3 ml. Insgesamt wurden 803 Pedikelschrauben gesetzt. Es traten im gesamten Kollektiv keine schraubenassoziierten Komplikationen auf. Der Vergleich unserer Daten in Freihandtechnik mit Literaturdaten zeigte eine für den Patienten deutlich höhere Strahlenexposition bei der fluoroskopisch gestützten und computertomografisch gestützten Technik.Anhand der Ergebnisse konnte gezeigt werden, dass die dorsale Instrumentation mit Pedikelschrauben-Doppelstabsystem in Freihandtechnik bei Patienten mit adoleszenter und adulter idiopathischer Skoliose mit einer erheblich geringeren intraoperativen Strahlenbelastung im Vergleich zu navigierten Verfahren einhergeht. Dabei ist die Art des navigierten Verfahrens unerheblich. Eine erhöhte Strahlenexposition der meist jungen Patienten ist verbunden mit einem erhöhten langfristigen Risiko für das Auftreten strahleninduzierter maligner Erkrankungen. Bei entsprechender chirurgischer Erfahrung können Pedikelschrauben in Freihandtechnik mit vergleichbarer Genauigkeit sicher und effektiv gesetzt werden, führen jedoch zu einer signifikant geringeren Strahlenbelastung für den Patienten.
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- 2020
28. [Collected data on freehand technique instrumentation and literature comparison on fluoroscopic and CT-assisted navigation]
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C, Berlin, U, Platz, M, Quante, B, Thomsen, M, Köszegvary, and H, Halm
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Young Adult ,Spinal Fusion ,Adolescent ,Scoliosis ,Surgery, Computer-Assisted ,Pedicle Screws ,Fluoroscopy ,Humans ,Radiation Exposure ,Tomography, X-Ray Computed - Abstract
A proven and frequently used surgical procedure in patients with idiopathic scoliosis (IS) is posterior transpedicular corrective spondylodesis using the freehand technique. Novel procedures with fluoroscopically and computed tomography (CT)-assisted navigation are presumed to be less risky and more accurate.Is the freehand technique for IS safe with respect to screw-associated complications and intraoperative radiation exposure?Prospectively collected data (2017-2018) from 39 consecutive patients (average age 18.7 years) with thoracic single curvature IS (61.7° ± 13.9°) from a specialized scoliosis center were evaluated for the following parameters (mean ± standard deviation): total radiation product, fluoroscopy time, fused segments, operative time, blood loss and screw-associated complications. A comparison with data from the literature on intraoperative radiation exposure using navigation procedures was carried out.The total radiation product per patient was 71.7 ± 44.0 cGy*cmThe results of this study showed that with appropriate experience freehand positioning of pedicle screws is associated with comparable accuracy and less radiation exposure for patients than navigation procedures. With respect to the young age of patients, a radiation-induced long-term risk for malignant diseases should be taken into consideration.
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- 2020
29. Gut microbiota and oesophageal disease – an update
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T. Baumeister, M. Quante, and J. Bornschein
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eosinophilic oesophagitis ,oesophageal microbiota ,lcsh:R5-920 ,high fat diet ,toll-like receptor ,lcsh:Diseases of the digestive system. Gastroenterology ,lcsh:RC799-869 ,intestinal metaplasia ,lcsh:Medicine (General) ,barrett’s oesophagus ,digestive system diseases - Abstract
It is a matter of common knowledge that incidence rates of inflammatory and neoplastic conditions of the distal oesophagus, such as eosinophilic oesophagitis, Barrett´s oesophagus, oesophageal adenocarcinoma (OAC), and their common main risk factor gastro-oesophageal reflux disease (GORD) are on the rise. All conditions were linked to lifestyle-related risk factors such as diet or medication without a comprehensive understanding of the pathophysiological mechanisms involved. It is a very recent knowledge that the oesophagus harbours a specific and unique microbiome that changes in correlation with disease conditions. Recent epidemiological data indicate potential causative relationships between disease-specific risk factors, changes in the gastrointestinal microbiota composition, and disease progression, as already reported in other gastrointestinal diseases such as colorectal cancer. It is plausible that alterations in the microbial community might account for inflammatory or potential carcinogenic changes in the microenvironment via interference with the immune system, bacterial defence, and metabolic pathways. It is of crucial importance to accomplish a more comprehensive and systemic understanding of the complex mechanistic interactions between host, lifestyle, environment, and microbiota to elucidate the onset, progress, and potential therapy of oesophageal diseases, as well and their association with other diseases of the gastrointestinal tract.
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- 2020
30. A rare case of perivascular epithelioid cell tumor (PEComa) of the pancreas diagnosed by endoscopic ultrasound
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M. Quante, Anna Melissa Schlitter, Roland M. Schmid, Katja Specht, Güralp O. Ceyhan, C. Schlag, and J. D. Ulrich
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Endoscopic ultrasound ,medicine.medical_specialty ,medicine.medical_treatment ,Physical examination ,Neuroendocrine tumors ,Perivascular Epithelioid Cell ,03 medical and health sciences ,0302 clinical medicine ,Pancreatic tumor ,Case report ,medicine ,Pharmacology (medical) ,lcsh:RC799-869 ,medicine.diagnostic_test ,business.industry ,medicine.disease ,digestive system diseases ,ddc ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Pancreatectomy ,030211 gastroenterology & hepatology ,lcsh:Diseases of the digestive system. Gastroenterology ,Radiology ,Differential diagnosis ,Pancreas ,business - Abstract
A 49-year-old woman consulted her general practitioner (GP) regarding epigastric pain that she had experienced for 2 months. Physical examination and laboratory results were unremarkable. An abdominal ultrasound indicated a solid pancreatic tumor, which was confirmed on subsequent CT and MRI. Endoscopic ultrasound (EUS) showed a well-defined heterogeneous, predominantly hypoechoic mass in the pancreatic body, so a neuroendocrine tumor (NET) was suspected. However, EUS-guided fine-needle aspiration (EUS-FNA) was performed and based on (immuno-)histochemical findings, the extremely rare diagnosis of a perivascular epithelioid cell tumor (PEComa) of the pancreas was made. Due to the malignant potential of pancreatic PEComas, laparoscopic left-sided pancreatectomy was performed. We present a case diagnosed by preoperative EUS-FNA highlighting the clinical and endosonographic features which help to distinguish it from its most important differential diagnosis, neuroendocrine tumors (NETs) of the pancreas.
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- 2020
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31. Pathogenese und Prävention von ösophagealen Adenokarzinomen
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M. Quante and Theresa Baumeister
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Gynecology ,03 medical and health sciences ,medicine.medical_specialty ,0302 clinical medicine ,business.industry ,030220 oncology & carcinogenesis ,Gastroenterology ,Medicine ,030211 gastroenterology & hepatology ,business - Abstract
Osophageale Adenokarzinome (EAC) haben in der industrialisierten Welt die am schnellsten wachsende Inzidenzrate aller Tumorerkrankungen. Es ist fur die Gesundheitsversorgung unabdingbar, die Grunde dafur zu erkennen. Der wichtigste bekannte pramaligne Vorlaufer ist der Barrett-Osophagus (BE). Seine Entstehung wird bisher vor allem auf Inflammation durch chronischen Reflux zuruckgefuhrt. Ein praklinisches Mausmodell und aktuelle humane Studien deuten darauf hin, dass das EAC nicht im Osophagus, sondern in der Kardia des Magens entsteht. Durch die Entzundung angelockt expandieren Stammzellen von der Kardia in den Osophagus und tragen zur Karzinogenese bei. Forschungsergebnisse zeigen, dass die Aktivierung dieser Stammzellen durch eine Veranderung der inflammatorischen Mikroumgebung im Osophagus erfolgt, die vermutlich durch Faktoren, wie Geschlecht, Alter oder Ubergewicht, einhergehend mit genetischen und molekularen Veranderungen beeinflusst wird. Die Identifizierung dieser Faktoren ist zur besseren Risikostratifizierung und Etablierung praventiver Strategien notwendig. Ziel sollte es sein, geeignete Marker zur Aufdeckung von Hochrisikopatienten zu finden, um ein effizienteres und risikoadaptiertes Surveillance-Programm anzubieten. So kann jedoch insgesamt die Zahl der bisher notigen Surveillance-Endoskopien minimiert werden. Hierdurch wurden Aufwand und Kosten gesenkt und eine optimalere Versorgung der einzelnen Patienten gewahrleistet. Trotz vielversprechender Ansatze ist es bisher noch nicht gelungen, ein in der Klinik praktikables Set von Biomarkern zu etablieren, durch das dieses Ziel erreicht wird. Daher kommt der Forschung an Biomarkern fur BE in Zukunft weiterhin eine hohe Bedeutung zu.
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- 2017
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32. Pathogenese des Barrettkarzinoms
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M. Quante and M. Tobiasch
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Gastroenterology - Published
- 2017
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33. A case of cutaneousRhodotorulainfection mimicking cryptococcosis
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E. J. Topham, M. Quante, S. M. C. George, A. R. MacDiarmaid-Gordon, and M. D. Cubbon
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Male ,0301 basic medicine ,biology ,030106 microbiology ,Rhodotorula ,Cryptococcosis ,Dermatology ,Middle Aged ,medicine.disease ,biology.organism_classification ,Kidney Transplantation ,Diagnosis, Differential ,Immunocompromised Host ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Opportunistic pathogen ,0302 clinical medicine ,Renal transplant ,Immunology ,medicine ,Dermatomycoses ,Humans ,Kidney transplantation - Abstract
Rhodotorula is a ubiquitous environmental and commensal yeast, and an emerging opportunistic pathogen, particularly in immunocompromised individuals. Clinical infections with Rhodotorula have been increasingly recognized over the past 30 years; however, infections in solid-organ transplant recipients are uncommon, and cutaneous manifestations have rarely been reported. We describe a 59-year-old male renal transplant recipient, who developed cutaneous infection with Rhodotorula upon failure of his graft and commencement of haemodialysis.
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- 2016
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34. Die adulte lumbale de-novo-Skoliose
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M. Quante
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Gynecology ,Foraminal stenosis ,medicine.medical_specialty ,business.industry ,Lumbar instability ,medicine ,General Medicine ,business - Abstract
ZusammenfassungDie adulte lumbale de-novo-Skoliose entsteht als dreidimensionale Deformität im Erwachsenenalter. Ursächlich sind degenerative Veränderungen, Voroperationen, rheumatische und andere Erkrankungen. Typisches Symptom ist der lumbale, chronische Rückenschmerz. Die Deformität führt im Verlauf zu zentralen Stenosen oder Foraminalstenosen, was zu konsekutiven radikulären Symptomen führt, die das Krankheitsbild weiter verschlechtern. Entscheidend ist die rechtzeitige Erkennung der Deformität mittels nativradiologischer Untersuchung. Die Deformität bestimmt die weitere Behandlung. Wird die Deformität übersehen, besteht das Risiko einer fehlerhaften Behandlung. Konservativ sollte ein intensives Programm zum Aufbau der tiefen stabilisierenden Muskulatur dauerhaft durchgeführt werden, inklusive einer medikamentösen analgetischen Behandlung. Selektive Infiltrationen in Gelenke und neurale Strukturen helfen differenzialdiagnostisch und temporär therapeutisch. Eine Korsett behandlung ist in Einzelfällen hilfreich. Erst nach Ausreizen der konservativen und interventionellen Maßnahmen sollte bei klarem Leidensdruck die Indikation zur Operation überprüft werden. Üblicherweise ist operativ allein die konsequente dekomprimierende Korrekturspondylodese zielführend. In ausgesuchten Fällen kann ein selektives segmentales Vorgehen sinnvoll sein, wenn die strukturelle Pathologie der Beschwerden eindeutig einzelnen Segmenten zugeordnet werden kann.
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- 2016
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35. Erratum zu: Geringe intraoperative Strahlenbelastung für Skoliosepatienten
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H. Halm, U. Platz, M. Quante, C. Berlin, B. Thomsen, and M. Köszegvary
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Gynecology ,medicine.medical_specialty ,business.industry ,medicine ,Orthopedics and Sports Medicine ,business - Abstract
Sehr geehrte Leserin, sehr geehrter Leser, der oben genannte Beitrag wurde mit einem fehlerhaften Titel publiziert. Bitte beachten Sie den korrekten Titel und Untertitel: Geringe intraoperative Strahlenbelastung fur Skoliosepatienten. Freihandige Instrumentation mit Vergleich zur Navigation Wir …
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- 2020
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36. GEWEX Cloud System Study (GCSS) cirrus cloud working group: development of an observation-based case study for model evaluation
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G. G. Mace, Andrew N. Ross, M. Quante, S. Dobbie, and H. Yang
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Rapid update cycle ,Scale (ratio) ,Meteorology ,Computer science ,lcsh:QE1-996.5 ,Forcing (mathematics) ,law.invention ,lcsh:Geology ,law ,Millimeter cloud radar ,ddc:551 ,H1 ,Radiosonde ,Cirrus ,Satellite ,Large eddy simulation - Abstract
The GCSS working group on cirrus focuses on an inter-comparison of model simulations ranging from very detailed microphysical and dynamical models through to general circulation models (GCMs). The past GCSS cirrus cloud inter-comparison highlighted the wide range in modelling results that was a surprise to the modelling community. That inter-comparison was idealised and, therefore, a key issue was that it did not benefit from observations to help distinguish between model performances. In this work, we aim to address this key issue by developing an observationally based case study to be used for the GCSS cirrus modelling inter-comparison study. We focused on developing a case that had sufficient observations with which to evaluate models, to help identify which models in the inter-comparison are performing well and highlight areas for model development. Furthermore, it will provide a base case for future model comparisons or testing of new or updated models. This paper outlines the modelling case development and the inter-comparison results will be presented in a follow-on paper. The case was based on the 9 March 2000 Atmospheric Radiation Measurement (ARM) Southern Great Plains (SGP) during an intensive observation period (IOP). The case was developed utilising various observations including ARM SGP remote sensing including the MilliMeter Cloud Radar (MMCR), radiometers, radiosondes, aircraft observations, satellite observations, objective analysis and complemented with results from the Rapid Update Cycle (RUC) model as well as bespoke gravity wave simulations used to provide the best estimate for large scale forcing. The retrievals of ice water content, ice number concentration and fall velocity provide several constraints to evaluate model performances. Initial testing of the case has been reported using the UK Met Office Large Eddy Simulation Model (LEM) which suggests the case is appropriate for the model inter-comparison study. To our knowledge, this case offers the most detailed case study for cirrus comparison available and we anticipate this will offer significant benefits over past comparisons which have mostly been loosely based on observations.
- Published
- 2018
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37. Zeitlichkeit, personale Lebensform und Ethik
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M. Quante
- Published
- 2018
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38. Die GENESIS-Studie – genetische Biopsie zur Prädiktion des Überwachungsintervalls nach endoskopischer Resektion von Kolonpolypen
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Alexander Meining, Daniel Schwerdel, C Langner, E Zizer, F Oswald, A. Kleger, K Raedler, Lukas Perkhofer, L Ludwig, J Slotta-Huspenina, T Seufferlein, M Quante, N Dikopoulos, AW Berger, and KF Becker
- Published
- 2017
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39. Thromboseprophylaxe und Aggregationshemmer in der Wirbelsäulenchirurgie
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V. Bullmann, M.J.K. Simon, J. Klasen, R. Zamani, and M. Quante
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Gynecology ,medicine.medical_specialty ,Multicenter study ,Sports medicine ,business.industry ,medicine ,Orthopedics and Sports Medicine ,business - Abstract
Hintergrund Die perioperative Gabe von Antikoagulanzien (AK) und Thrombozytenaggregationshemmern (TAH) in der Wirbelsaulenchirurgie (WSC) suggeriert eine erhohte Rate epiduraler Blutungen, Daten dazu fehlen. Oft sind die Substanzen zur Verhinderung thromboembolischer Komplikationen unverzichtbar. Eine ubergreifende Handlungsempfehlung zum Einsatz von AK und TAH fehlt.
- Published
- 2014
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40. Bedeutung der Schlafendoskopie bei obstruktiv-schlafbezogener Atmungsstörung im Kindes- und Jugendalter
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M. Fischer, D. Kyas, M. Quante, Wieland Kiess, Andreas Dietz, Iris-Susanne Horn, and A. Merkenschlager
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Gynecology ,medicine.medical_specialty ,Otorhinolaryngology ,business.industry ,medicine ,Sleep disordered breathing ,business - Abstract
Zusammenfassung Hintergrund: Studien zur gezielten operativen OSAS-Therapie nach Medikamenten-induzierter Schlafendoskopie (MISE) konnten bei Erwachsenen ein verbessertes Outcome erzielen. Im Kindesalter liegen zu diesem Verfahren nur wenige Erfahrungen vor. Diese Studie evaluiert den differenzialdiagnostischen Stellenwert der MISE bei obstruktiven schlafbezogenen Atmungserkrankungen im Kindes- und Jugendalter. Es wird untersucht, ob initiale Therapie-Entscheidungen beeinflusst werden. Material und Methoden: Es wurden retrospektiv die Krankenakten von 25 Kindern mit obstruktiver schlafbezogener Erkrankung analysiert, die im Zeitraum von 05/2012 bis 12/2013 eine Polysomnografie und Schlafendoskopie erhalten hatten. Anhand des Grades der obstruktiven schlafbezogenen Erkrankung wurden 2 Gruppen gebildet (Upper airway resistence syndrome (UARS) und mildes OSAS: AHI Ergebnisse: Häufigster Ort einer Obstruktion war die Oropharynx-Ebene. Ein moderates oder schweres OSAS war signifikant mit einer vollständigen Obstruktion auf Oropharynx-Ebene assoziiert (p=0,02). Zudem fand sich ein signifikanter Zusammenhang zwischen der Adenoidgröße und dem Obstruktionsmuster auf VelopharynxEbene (p=0,02). Eine vollständige Obstruktion auf Oropharynx-Ebene konnte bei 71% der Kinder mit Tonsillengröße IV gefunden werden. Es bestand keine Assoziation zwischen der Adenoid- und Tonsillengröße und dem Ausprägungsgrad der schlafbezogenen Atmungsstörung. Bei 5 Kindern (20%) ergab sich ein Erkenntniszugewinn mit Anpassung der initial geplanten Therapien. Schlussfolgerung: Die Medikamenten-induzierte Schlafendoskopie erscheint ein vielversprechendes Verfahren mit therapeutischer Konsequenz, um Obstruktionen beim kindlichen OSAS topografisch zu beurteilen. Weitere Studien sind jedoch notwendig, um verlässliche Vorhersageparameter für potenzielle Therapieversager nach operativer Therapie zu etablieren.
- Published
- 2014
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41. [Is it necessary to ascertain intestinal metaplasia with goblet cells for the diagnosis of Barrett Esophagus?]
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M, Quante
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Barrett Esophagus ,Metaplasia ,Esophagus ,Esophageal Neoplasms ,Humans ,Esophagoscopy ,Goblet Cells ,Adenocarcinoma - Published
- 2016
42. Was sind die Gründe der Patientenpräferenz? Vergleich von oraler und subkutaner Darreichungsform
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I.-M. Thate-Waschke, M. Schofer, and M. Quante
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Gynecology ,medicine.medical_specialty ,business.industry ,Medicine ,Orthopedics and Sports Medicine ,Surgery ,business ,Patient preference - Abstract
Hintergrund: Aktuell sind fur die Thromboseprophylaxe nach Huft- und Kniegelenkendoprothesen zahlreiche subkutan und 3 oral applizierbare Substanzen zugelassen. Wahrend die allgemeine Auffassung besagt, dass Patienten die orale Medikation befurworten, gibt es in fachlicher Hinsicht groses Interesse an den Beweggrunden der Patienten fur die Bevorzugung einer oralen oder subkutanen Applikation. Letztlich ist zu erwarten, dass die kompetente Berucksichtigung von Patientenpraferenzen die Compliance erhoht. Die vorliegende Studie soll eine Analyse der Patientenpraferenzen hinsichtlich oraler bzw. subkutaner Thromboseprophylaxe nach elektiven Huft- oder Kniegelenkersatzoperationen erlauben. Anhand der Ergebnisse sollen Ruckschlusse fur den klinischen Alltag und die Wahl der einen oder anderen Applikationsform gewonnen werden. Methodik: Es handelt sich um eine nicht interventionelle, prospektive, multizentrische Beobachtungsstudie, die in 6 Akut- sowie 6 Rehabilitationskliniken durchgefuhrt wurde. Befragt wurden 178 Patienten nach elektiver Huft- oder Kniegelenkersatzoperation, die eine subkutane (niedermolekulare Heparine zur Thromboseprophylaxe) sowie orale Medikation erhielten. Die subjektive Beurteilung der Prozesse und die Beurteilung der Praferenz einer der beiden Applikationsformen durch die Patienten erfolgten auf eigens fur dieses Projekt entwickelten Fragebogen (allgemeine Angaben, Status orale Dauermedikation, Details zur subkutanen Thromboseprophylaxe, Praferenz der Applikationsform, Grunde fur die Praferenz). Ergebnisse: 71,9 % aller Patienten gaben an, eine orale Thromboseprophylaxe zu bevorzugen, sofern sie die Wahl hatten. Lediglich 14,6 % wurden weiterhin die tagliche subkutane Gabe bevorzugen. Grunde fur die deutliche Praferenz der oralen Applikationsform waren die einfachere (86,6 % Nennungen), weniger aufwendige (73,1 % Nennungen) Handhabung sowie die geringe Bedeutung einer weiteren Tablette (70,9 % Nennungen). Fur 65,7 % der Nennungen war die geringere Schmerzhaftigkeit bei der Tablette entscheidend. Die masgeblichen Nennungen fur die subkutane Applikation waren die hohere Applikationssicherheit (55,3 % Nennungen) sowie die Annahme einer per se besseren Wirksamkeit einer Spritze (47,4 % Nennungen). Die Storung der Befindlichkeit durch die subkutane Gabe nimmt mit zunehmendem zeitlichen Abstand zur OP zu. Ein geringer Teil der Patienten (
- Published
- 2012
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43. Transforaminale lumbale interkorporelle Fusion zur Versorgung der degenerativen Spondylolisthese
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M. Quante, H. Halm, H. Kesten, and A. Richter
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Gynecology ,medicine.medical_specialty ,business.industry ,Treatment outcome ,Medicine ,Orthopedics and Sports Medicine ,business - Abstract
Die degenerative Spondylolisthese (DS) ist eine haufige Ursache chronisch rezidivierender Lumbalgien sowie radikularer Beinschmerzen. Bei einer Fusion sollten symptomatische degenerierte Nachbarsegmente („degenerative disc disease“, DDD) einbezogen werden. In dieser Arbeit wird die tansforaminale lumbale interkorporelle Fusion (TLIF) hinsichtlich ihrer Ergebnisse bei Patienten mit monosegmentaler degenerativer Spondylolisthese und einem degenerierten Anschlusssegment untersucht. Es handelte sich um 28 Patienten mit monosegmentaler DS und einem symptomatischen Anschlusssegment mit DDD (alle bisegmental dorsal instrumentiert und fusioniert, ventral 14 bisegmentale TLIF, 14 monosegmentale TLIF). Die Werte der visuellen Analogskala (VAS) Schmerz und des Oswestry Disability Index (ODI) wurden ermittelt, auserdem erfolgte eine radiometrische Auswertung pra- und 12 Monate postoperativ. Weiter wurde die vergleichende Subanalyse der bi- mit monosegmentaler interkorporeller Abstutzung vorgenommen. Die Schmerzreduktion war signifikant (VAS von 8,7 auf 3,1), der ODI verbesserte sich ebenfalls signifikant von 63 auf 28%. Radiologisch wurden die Segmenthohe und das Wirbelgleiten (Etagen mit TLIF und Spondylolisthese) signifikant verbessert. Die bisegmentale ventrale Abstutzung zeigte gegenuber der monosegmentalen Vorgehensweise eine signifikant bessere Relordosierung. Bei monosegmentaler DS mit symptomatischem Anschlusssegment stellt die Versorgung der Spondylolisthese mittels TLIF ein sicheres und effektives Verfahren dar. In der klinischen Ergebnislage zeigt sich fur das degenerierte Nachbarsegment kein Unterschied zwischen der zusatzlichen interkorporellen Abstutzung und der alleinigen dorsalen Fusion. Allerdings ergeben sich durch eine zusatzliche ventrale Abstutzung Vorteile fur die Relordosierung des Segments, sodass mogliche langfristige Effekte zugunsten der bisegmentalen TLIF diesbezuglich untersucht werden sollten.
- Published
- 2011
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44. Liver Transplantation to Treat Suspected Hepatocellular Carcinoma in Iron-Free Foci in Congenital Hemochromatosis: Case Report
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S. Jonas, C. Benckert, Michael Bartels, A. Thelen, M. Moche, C. Wittekind, D. Uhlmann, M. Quante, and Matthias M. Dollinger
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Adult ,Male ,medicine.medical_specialty ,Pathology ,Carcinoma, Hepatocellular ,medicine.medical_treatment ,Liver transplantation ,Gastroenterology ,Liver disease ,Internal medicine ,medicine ,Humans ,Hemochromatosis ,Transplantation ,medicine.diagnostic_test ,business.industry ,Liver Neoplasms ,Immunosuppression ,medicine.disease ,Magnetic Resonance Imaging ,digestive system diseases ,Liver Transplantation ,Hepatocellular carcinoma ,Liver biopsy ,Surgery ,Siderosis ,business - Abstract
Hepatocellular carcinoma (HCC) commonly develops in cirrhotic or noncirrhotic livers affected by congenital hemochromatosis. In patients with congenital hemochromatosis and HCC, liver transplantation is a therapeutic option with a 5-year posttransplantation survival rate as high as 80%. Herein is reported congenital hemochromatosis in a 37-year-old man. During a routine checkup, 2 liver nodules were detected. Signal characteristics at magnetic resonance imaging indicated the presence of iron-free foci (IFF). The serum α-fetoprotein concentration was within the range of normal, and repeated liver biopsy did not show histomorphologic signs of malignancy but confirmed the presence of IFF in surrounding siderosis. The patient was listed for liver transplantation with match MELD (Model of End-Stage Liver Disease including exceptions) because of suspected HCC. After 173 days on the waiting list, liver transplantation was performed successfully. Histologic examination of the explanted liver confirmed 2 HCC lesions with a diameter of 0.9 cm in the exact projection as the IFF detected at magnetic resonance imaging. At 20 months of rapamycin-based immunosuppression therapy, there were no signs of HCC recurrence. This is, to our knowledge, the first report of liver transplantation performed to treat suspected HCC based on the finding of IFF in congenital hemochromatosis, with histopathologic confirmation of the diagnosis of HCC after transplantation. According to this case and the current literature, IFF in patients with congenital hemochromatosis should be considered preneoplastic lesions vulnerable to possible development of HCC.
- Published
- 2011
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45. Subkutane versus orale Arzneimittelapplikation
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I.-M. Thate-Waschke, M. Quante, and M. Schofer
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medicine.medical_specialty ,Knee prosthesis ,business.industry ,Health Policy ,medicine ,Heparin ,business ,Surgery ,medicine.drug - Published
- 2010
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46. Die modifizierte primärstabile ventrale Derotationsspondylodese mit dem Halm-Zielke-Instrumentarium (HZI) zur Behandlung der idiopathischen Skoliose
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Alexander Richter, Anja Macherei, H. Halm, and M. Quante
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Gynecology ,Bone screws ,medicine.medical_specialty ,business.industry ,medicine ,Orthopedics and Sports Medicine ,Surgery ,business ,Scoliosis surgery - Abstract
Ventrale dreidimensionale Korrektur einer skoliotischen Deformitat sowohl in der koronaren als auch in der sagittalen Ebene mit Schaffung eines physiologischen Wirbelsaulenprofils bei moglichst kurzer Fusionsstrecke. Skoliotische Deformitat mit thorakaler, lumbaler oder thorakolumbaler Hauptkrummung zwischen 40° und 90° (Cobb) im Bereich von Th4 bis L4. Die Indikation zur selektiven anterioren Korrektur der idiopathischen Skoliose muss anhand der Lokalisation der Deformitat unter Berucksichtigung der Flexibilitat (der Haupt- und Nebenkrummung) und des sagittalen Profils (Lordose, Kyphose) erfolgen. Nach der Lenke-Klassifikation eignen sich fur ein solches Operationsverfahren vor allem der Typ 1 („main thoracic“) und der Typ 5 („thoracolumbar/lumbar“). Osteoporose. Infektion. Metallallergie (Titan Ti 6Al-4V). Fehlende Flexibilitat der Nebenkrummung. Strukturelle Kyphose im Bereich der Hauptkrummung. Pathologische Kyphose kranial oder kaudal der geplanten Instrumentation. Zugangsweg und Praparation des Instrumentationsbereichs entsprechend der Thorakotomie und Thorakophrenolumbotomie mit Darstellung der ventralen Wirbelsaule. Vollstandige Diskektomie im Fusionsbereich und Fixation der Bugelplatten seitlich an den Wirbelkorpern mit zwei divergierend eingebrachten Schrauben, die bikortikal verankert werden. Korrektur der Deformitat uber verschiedene Manover wie Cantilever-Forces, Stabrotation und segmentale Kompression. Erzielen der Primarstabilitat durch Einbringen eines rigiden und teilflexiblen Stabs (Doppelstabsystem). Schichtweiser Wundverschluss der Thorakotomie unter Einlage einer Bulau-Drainage. Korsettfreie Nachbehandlung. Physiotherapie. Atemtherapie. Nahezu immer Erreichen der knochernen Spondylodese. Exzellente und nachhaltige frontale Korrektur von 60–70%. Sehr gute spontane Korrektur der kranialen und auch der lumbalen Nebenkrummung von ca. 40% sowie Herstellung eines physiologischen Profils. Fusionsstrecke und Korrekturwinkel vergleichbar mit modernen dorsalen transpedikularen Doppelstabsystemen.
- Published
- 2010
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47. Orale Thromboembolieprophylaxe mit Rivaroxaban und Dabigatran: Sind die Neuzulassungen Innovationen für die operative Orthopädie und Unfallchirurgie?
- Author
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W. Gogarten, M. Quante, and R. Pauschert
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medicine.medical_specialty ,Rivaroxaban ,Joint replacement ,business.industry ,medicine.medical_treatment ,Guideline ,medicine.disease ,Thrombosis ,Surgery ,Dabigatran ,Hip replacement ,Orthopedic surgery ,medicine ,Orthopedics and Sports Medicine ,Intensive care medicine ,business ,Trauma surgery ,medicine.drug - Abstract
Today the indication for thrombosis prophylaxis is a relevant and daily concern in orthopaedic surgery. Recently there are some changes concerning the German guidelines, which are approved by 27 German medical societies. For the first time the guidelines give distinct recommendations for the different indications, the kind of thrombosis prophylaxis and its duration. Some of the recommendations will lead to changes of both processes in outpatient and inpatient management. In parallel 2 new oral anticoagulants have been approved for the prevention of thromboembolic events after elective knee and hip replacement. Dabigatran is an oral thrombin inhibitor. Compared to enoxaparin it has a comparable profile of side effects and efficacy. Rivaroxaban is an oral Xa inhibitor which shows a significantly better efficacy compared to enoxaparin and no difference in side effects. The significant reduction of symptomatic thromboembolisms after elective knee and hip replacement was shown for rivaroxaban compared to enoxaparin in a pooled analysis of phase III data. This review discusses the main topics of the new German guideline and impact of the new oral anticoagulants on in- and outpatient treatment procedures.
- Published
- 2010
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48. Fortschritte bei der Therapie des akuten Leberversagens
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M. Quante, S. Jonas, C. Benckert, and G. Gäbelein
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Emergency Medicine ,Critical Care and Intensive Care Medicine - Published
- 2009
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49. Anterior scoliosis surgery
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H. Halm, M. Ahrens, B. Thomsen, M. Köszegvary, A. Richter, and M. Quante
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business.industry ,Medicine ,Orthopedics and Sports Medicine ,business ,Nuclear medicine - Published
- 2009
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50. Die operative Behandlung der adulten Skoliose
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A. Richter, M. Quante, H. Halm, M. Köszegvary, and B. Thomsen
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medicine.medical_specialty ,Cobb angle ,Spinal stenosis ,business.industry ,Kyphosis ,Scoliosis ,medicine.disease ,Surgery ,Coronal plane ,Back pain ,medicine ,Deformity ,Orthopedics and Sports Medicine ,medicine.symptom ,business ,Lumbosacral joint - Abstract
Adult scoliosis is defined as a spinal deformity with a Cobb angle of more than 10 degrees in the coronal plain in a skeletally mature patient. Patients predominantly suffer from back pain symptoms, often accompanied by signs of spinal stenosis (central as well as lateral). Asymmetric degeneration leads to asymmetric load and therefore to a progression of the degeneration and deformity as either scoliosis (0.5-1 degree per year), kyphosis, or both. The diagnostic evaluation includes static and dynamic imaging, magnetic resonance imaging, and myelo-computed tomography, as well as invasive diagnostic procedures such as discograms, facet blocks, and epidural and root blocks. The treatment, either conservative or surgical, is then tailored to the patient's specific symptomatology. Surgical management is usually complex and must take into account an array of specific problems, including the patient's age and general medical condition, the length of the fusion, the condition of the adjacent segments, the condition of the lumbosacral junction, osteoporosis, and any previous scoliosis surgery. The main goal of corrective surgery is a balancing of the coronal and sagittal planes.This review focuses on the special indications for vertebral body cement augmentation in patients with osteoporosis and the problem of adjacent level degeneration and its surgical management.
- Published
- 2009
- Full Text
- View/download PDF
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