41 results on '"M Morvay"'
Search Results
2. Factor analysis of training load determining a sport performance of a race walker for 35 kilometres
- Author
-
J. Broďáni, M. Spišiak, and M. Morvay
- Published
- 2022
- Full Text
- View/download PDF
3. 3D QSAR analysis of novel 5-HT1A receptor ligands
- Author
-
M. Morvay, Péter Mátyus, and A.P. Borosy
- Subjects
Quantitative structure–activity relationship ,Chemistry ,Stereochemistry ,Process Chemistry and Technology ,Biological activity ,Latent variable ,Field analysis ,Computer Science Applications ,Analytical Chemistry ,Set (abstract data type) ,Pharmacophore ,Biological system ,Spectroscopy ,Software - Abstract
In an effort to develop a quantitative ligand-binding model for 5-HT 1A receptors, a pharmacophore mapping procedure, DIStance COmparison (DISCO) was used to identify structural features that are common in a novel set of pyridazinothiazepines and pyridazinooxazepines with moderate-to-high affinity to 5-HT 1A -receptors. The pharmacophore thus obtained provided a good starting point for a Comparative Molecular Field Analysis (CoMFA) study. The CoMFA gave acceptable statistical measure ( R CV 2 =0.52 by using six latent variables, whereas it afforded a noncross-validated R 2 value of 1.00). Predictability of our model was tested by a separated prediction set of four compounds, for them the relative deviations between calculated and measured biological activity values did not exceed 10%.
- Published
- 1999
- Full Text
- View/download PDF
4. [Are the hemochromatosis (HFE) gene mutation and hepatitis C virus (HCV) infection risk factors for porphyria cutanea tarda?]
- Author
-
Z, Nagy, F, Kószó, A, Pár, A, Nagy, M, Horányi, M, Morvay, A, Dobozy, and G, Mózsik
- Subjects
Adult ,Male ,Porphyria Cutanea Tarda ,Heterozygote ,Hungary ,Homozygote ,Hepacivirus ,Middle Aged ,Hepatitis C ,Risk Factors ,Mutation ,Humans ,RNA, Viral ,Female ,Genetic Predisposition to Disease ,Hemochromatosis ,Alleles ,Aged - Abstract
As it is not clear whether mutations in hemochromatosis gene (HFE) and hepatitis C virus (HCV) act independently in the pathogenesis of porphyria cutanea tarda (PCT), and prevalence of both risk factors reveals a great variety in different parts of the world, PCT patients from our Central East European country were investigated for this aspect. The occurrence of the C282Y and H63D mutations in HFE gene were determined in 19 PCT patients and compared with the reported control frequencies. Furthermore, the presence of HCV infection was determined and related to the patients' HFE status. The C282Y mutation was found in 3/19 cases (one patient was homozygous and two heterozygous), with an 10.5% allele frequency (vs. 3.8% control) (p0.05). Five patients were heterozygous for the H63D mutation, allele frequency 13.1%, which did not differ from the reported control prevalence of 12.3%. Six patients (31.7%) were HCV-RNA positive, out of the six one was heterozygous for H63D mutation and one was compound heterozygous. HCV infection and HFE C282Y mutations may probably be independent predisposing factors for development of PCT in Hungarian patients.
- Published
- 2000
5. Novel proline substitution mutations in keratin 16 in two cases of pachyonycia congenita type 1
- Author
-
Colin S. Munro, M. Del Monaco, Whi McLean, F.J.R. Rietveld, Peter M. Steijlen, M. Morvay, C. M. Coleman, Frances J.D. Smith, and Jouni Uitto
- Subjects
Male ,Proline ,Pseudogene ,Mutation, Missense ,Nails, Malformed ,Classificatie van genodermatosen ,Dermatology ,Biology ,medicine.disease_cause ,Keratin 16 ,Cataract ,Ectodermal Dysplasia ,Keratin ,medicine ,Humans ,Pachyonychia congenita ,Tumor pathology ,Skin ,Genetics ,chemistry.chemical_classification ,Mutation ,Keratin Filament ,integumentary system ,Infant ,Tumor pathologie ,medicine.disease ,Phenotype ,Pedigree ,Palmoplantar keratoderma ,chemistry ,Keratins ,Classification of genodermatoses ,Female - Abstract
Pachyonychia congenita (PC) is a group of inherited ectodermal dysplasias, the characteristic phenotype being hypertrophic nail dystrophy. Two main clinical subtypes, PC-1 and PC-2, are inherited as autosomal dominant disorders, but other less well characterized clinical forms also exist. The PC-1 phenotype may be distinguished by the absence of the epidermal cysts found in PC-2, and it has been shown to be caused by mutations in either keratin K16 or its expression partner, the K6a isoform of K6. Mutations in K16 have also been shown to cause a milder related phenotype, focal non-epidermolytic palmoplantar keratoderma. Recently, we have developed a long-range polymerase chain reaction (PCR) strategy which allows specific amplification of the entire functional K16 gene (KRT16A), without amplification of the two K16 pseudogenes (psiKRT16B and psiKRT16C), enabling mutation analysis based on genomic DNA. Here, using this methodology, we describe novel mutations R127P and Q122P in the helix 1A domain of K16 in two families presenting with PC-1. Both mutations were excluded from 50 normal unrelated individuals by restriction enzyme analysis of K16 PCR fragments. In one family, ultrastructural analysis was performed, revealing distinctive tonofilament abnormalities. Specifically, keratin filament bundles were greatly condensed, but did not form the dense amorphous aggregates seen in a number of other keratin disorders. In the second kindred, autosomal dominant cataract was present in some but not all members affected by PC. As the cataract phenotype did not fully cosegregate with the K16 mutation, and given that K16 is not expressed in the lens, these two phenotypes may be coincidental.
- Published
- 1999
6. Juvenile pemphigus foliaceus
- Author
-
M, Mehravaran, M, Morvay, K, Molnár, J, Oláh, I, Korom, S, Husz, and A, Dobozy
- Subjects
Fluorescent Antibody Technique, Direct ,Prednisolone ,Anti-Inflammatory Agents, Non-Steroidal ,Humans ,Female ,Child ,Dapsone ,Glucocorticoids ,Pemphigus ,Autoimmune Diseases - Abstract
A 7-year-old girl with generalized erythematous, scaling plaques and vesiculobullous lesions on the extremities was diagnosed as having pemphigus foliaceus. Lesional direct immunofluorescence revealed intercellular IgG, IgA and C3 deposition. The patient's serum gave positive reactions against one epitope of desmoglein 3 and the epitope of desmoglein 1 in enzyme-linked immunosorbent assays, but the blood sample for indirect immunofluorescence did not display any circulating antibodies. The patient was successfully treated systemically with prednisolone and dapsone. Currently, she is taking dapsone, 12.5 mg daily. She has been free of lesions for the last 3 years.
- Published
- 1998
7. [New lasers in dermatologic surgery]
- Author
-
M, Morvay
- Subjects
Lasers ,Humans ,Dermatology ,Laser Therapy ,Photosensitivity Disorders ,Phototherapy ,Skin Diseases ,Forecasting - Abstract
Developments in the fields of laser technology and application have significantly broadened its clinical use over the past two decades. As lasers became more smaller, more reliable and less expensive, dermatology will benefit new laser-based therapeutic and diagnostic methods. Relevant laser systems and their clinical applications are presented, as are investigational laser systems, which may be of importance for the future in dermatology. We review advances in the use of pulsed lasers for treating vascular and non-vascular, pigmented epidermal and dermal lesions, for precise cutting of tissue, for photodynamic therapy and the future role of diode lasers in dermatological laser surgery is also discussed.
- Published
- 1995
8. [Chronic hemodialysis-related porphyria/pseudoporphyria]
- Author
-
F, Kószó, M, Földes, M, Morvay, R, Judák, G, Vakis, and A, Dobozy
- Subjects
Male ,Porphyria Cutanea Tarda ,Skin Diseases, Vesiculobullous ,Renal Dialysis ,Humans ,Kidney Failure, Chronic ,Uroporphyrinogen Decarboxylase ,Female ,Uroporphyrins - Abstract
In a considerable proportion of the patients with chronic renal failure, skin changes resembling porphyria cutanea tarda (PCT) develop some months to years after the onset of maintenance hemodialysis. This can be either real PCT, or secondary PCT, or PCT-like bullous dermatosis. In a minor proportion, real PCT can be diagnosed. In such cases, elevated total porphyrin levels with a predominance of uro- (IIII) and heptacarboxyl porphyrins (IIII) can be measured in the plasma (also in the urine, if not anuric), and fecal (perhaps urinary as well) isocoproporphyrin can be detected. The activity of the hepatic uroporphyrinogen decarboxylase (UD) is decreased in every type of PCT; in PCT-II, also that of the erythrocyte UD. In a higher proportion, secondary PCT (pseudo-PCT) develops. In this group, porphyrins are accumulated in the plasma due to the unsatisfactory renal function. Uro and hepta are the dominant fractions here as well, but alteration in the ratio of the uro isomers or the presence of isocoproporphyrin can not be expected. The UD activity is probably normal in every tissue. In 1% to 18% of the cases, PCT-like bullous dermatoses develop, but porphyrins are at normal levels in all compartments. The phototoxic agent here is other than porphyrin (e.g. nalidixic acid, furosemide, tetracycline, etc., or unknown). The authors review the knowledge on chronic hemodialysis-related PCT or the PCT-like bullous dermatoses: development of the above-mentioned conditions, clinical and morphological and biochemical features, difficulties in diagnosis, or the possibilities in therapy.
- Published
- 1994
9. [Ocular manifestations in porphyria cutanea tarda]
- Author
-
H, Hammer, I, Korom, M, Morvay, and M, Simon
- Subjects
Cornea ,Male ,Porphyria Cutanea Tarda ,Porphyrins ,Eye Diseases ,Ultraviolet Rays ,Sunlight ,Humans ,Female ,Photosensitivity Disorders ,Eye ,Conjunctiva - Abstract
Ninety two patients suffering from porphyria cutanea tarda were examined ophthalmologically in a paired case-control study. The incidence of pinguecula and that of pterygium were 8 times and 2 times higher, respectively, in PCT patients that in the control group. The photodamage of the conjunctiva is presumed to be a result of the photoactivity of uroporphyrin in the tissues.
- Published
- 1992
10. Erythrocyte uroporphyrinogen decarboxylase activity in 80 unrelated patients with porphyria cutanea tarda
- Author
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M. Morvay, F. Kószó, Attila Dobozy, and N. Simon
- Subjects
Adult ,Male ,congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Erythrocytes ,Uroporphyrinogen III decarboxylase ,Urinary system ,Dermatology ,Gastroenterology ,Skin Diseases ,Pathogenesis ,Porphyrias ,Sex Factors ,Internal medicine ,parasitic diseases ,medicine ,Humans ,Uroporphyrinogen Decarboxylase ,Porphyria cutanea tarda ,Family ,Uroporphyrinogen decarboxylase activity ,Aged ,Familial form ,business.industry ,Age Factors ,Middle Aged ,bacterial infections and mycoses ,medicine.disease ,Porphyria ,Endocrinology ,Increased risk ,Female ,business ,hormones, hormone substitutes, and hormone antagonists - Abstract
Summary To estimate the prevalence of the subgroups of porphyria cutanea tarda (PCT), erythrocyte uroporphyrinogen decarboxylase (UD) activity was measured in 80 unrelated patients with PCT, and in 45 of their relatives by using pentacarboxyl-porphyrinogen III as substrate. The subgroups were differentiated by analysis of the urinary porphyrins of the patients and 119 of their relatives. Of the patients, 77·5% were found to be suffering from the sporadic form of PCT (type I PCT), and 22·5% from the familial form (type II PCT), Every patient with PCT had previously been affected by alcohol, oestrogen or some other liver-damaging factor. The relative frequency of familial PCT was higher in females (nine of 15) than in males (nine of 65), which suggests that inheritance of the gene for type II PCT may predispose to oestrogen-precipitated PCT. The onset of type II PCT occurred at a lower age than that of type I (42·6 vs. 47·0 years). The findings suggest an increased risk of precipitating factors in carriers of an inherited UD deficiency.
- Published
- 1992
11. Polygenic Heredity of Porphyria cutanea tarda
- Author
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János Hunyadi, M. Morvay, and Attila Dobozy
- Subjects
Genetics ,business.industry ,Heredity ,Medicine ,Porphyria cutanea tarda ,Dermatology ,business ,medicine.disease ,medicine.disease_cause - Published
- 1990
- Full Text
- View/download PDF
12. [Porphyria sclerodermiformis]
- Author
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M, Simon, I, Korom, L, Szekeres, M, Morvay, and F, Kószó
- Subjects
Adult ,Male ,Porphyrias ,Scleroderma, Systemic ,Humans ,Female ,Middle Aged ,Skin Diseases ,Aged ,Skin - Published
- 1986
13. [The role of frozen sections in the intraoperative diagnosis of skin cancer]
- Author
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I, Korom, C, Bertényi, K, Kapitány, M, Morvay, and E, Dobó
- Subjects
Diagnosis, Differential ,Intraoperative Period ,Skin Neoplasms ,Carcinoma, Basal Cell ,Frozen Sections ,Humans ,Microtomy ,Melanoma - Published
- 1986
14. [Erythrocyte protoporphyrin studies in hepato-erythropoietic porphyria]
- Author
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F, Kószó, M, Morvay, M, Kiss, M, Simon, A, Dobozy, and G, Varga
- Subjects
Porphyrias ,Erythrocytes ,Porphyrins ,Liver Diseases ,Humans ,Protoporphyrins ,Erythropoiesis ,Female ,Aged - Published
- 1988
15. Repigmentation of vitiligo macules treated topically with Efudix cream
- Author
-
E, Szekeres and M, Morvay
- Subjects
Adult ,Male ,Administration, Topical ,Vitiligo ,Skin Pigmentation ,Middle Aged ,Ointments ,Microscopy, Electron ,Humans ,Melanocytes ,Female ,Fluorouracil ,Child ,Skin - Abstract
Repigmentation has been observed under the influence of topically administered Efudix cream in 3 patients with vitiligo of symmetrical acral type. No response has been received in 2 patients with segmental vitiligo treated in the same way. Recurrence of vitiligo was seen in 1 patient. Histologic and electron microscopic characterization of recolonized melanocytes is described. The significance of topical 5-fluorouracil treatment in vitiligo is discussed.
- Published
- 1985
16. [Secondary malignant tumor associated with melanoma]
- Author
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I, Korom, L, Szekeres, C, Bertényi, and M, Morvay
- Subjects
Adult ,Male ,Neoplasms, Multiple Primary ,Leukemia ,Lymphoma ,Carcinoma ,Humans ,Female ,Middle Aged ,Melanoma ,Aged - Published
- 1985
17. [Coexistence of porphyria cutanea tarda and lupus erythematosus]
- Author
-
M, Morvay, J, Hunyadi, F, Kószó, M, Kiss, A, Dobozy, and N, Simon
- Subjects
Adult ,Porphyrias ,Lupus Erythematosus, Discoid ,Lupus Erythematosus, Cutaneous ,Humans ,Lupus Erythematosus, Systemic ,Female ,Skin Diseases - Abstract
We report on the appearance of porphyria cutanea tarda in a patient with systemic LE and in two patients with discoid LE. A review is given on the corresponding literature. It is suggested that both lupus erythematosus and porphyria cutanea tarda have multifactorial inheritance. The cause of coexistence can be common genes responsible for the genetic determination which also predispose to the occurrence of both diseases. The question of etiology still remains obscure. This coexistence raises, however, a more practical question as regards the therapeutic modalities for the two diseases.
- Published
- 1989
18. [Sclerodermiform porphyria]
- Author
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N, Simon, I, Korom, L, Szekeres, M, Morvay, and F, Kószó
- Subjects
Actin Cytoskeleton ,Microscopy, Electron ,Porphyrias ,Scleroderma, Localized ,Porphyrins ,Humans ,Collagen ,Skin Diseases ,Facial Dermatoses ,Skin - Abstract
We give a retrospective survey on the clinical, histological, biochemical, and pathogenetical aspects of sclerodermiform changes rarely accompanying porphyria cutanea tarda (PCT). Sclerodermiform changes were seen in 12 patients (2% of all our PCT cases). In these patients, no correlation was found between the severity of the dermatological signs and symptoms and the degree of disturbance in the porphyrin metabolism. Biochemical remission was not accompanied by improvement of the sclerodermiform changes. The proportion of porphyrins with 4 or 5 COOH-groups was higher than that of PCT patients without sclerosis. The findings are consistent with the view that the development of sclerodermiform changes cannot be merely explained by phototoxic reactions, but the "dark-effect" of the porphyrins may also play an important role in the pathogenesis.
- Published
- 1986
19. Oral tacrolimus for severe recalcitrant eosinophilic cellulitis.
- Author
-
Morvay M, Bergman R, and Avitan-Hersh E
- Published
- 2020
- Full Text
- View/download PDF
20. Study of the International Epidemiology of Androgenetic Alopecia in Young Caucasian Men Using Photographs From the Internet.
- Author
-
Avital YS, Morvay M, Gaaland M, and Kemény L
- Abstract
Background: The epidemiological evaluation of androgenetic alopecia (AGA) is based mainly on direct observation and questionnaires. The international epidemiology and environmental risk factors of AGA in young Caucasian men remain unknown., Aim: To use photographs and data from the Internet to evaluate severe AGA and generate greater understanding of the international epidemiology of the disorder in young Caucasian men., Materials and Methods: A population-based cross-sectional study design was used. The sample included 26,340 Caucasian men aged 30 to 40 years who had uploaded profiles to two dating websites. Their photographs were evaluated for AGA and graded as follows: severe AGA (Norwood type VI-VII), non-severe AGA, and unknown. Epidemiological data were collected from the sites. Logistic regression was used to analyze the effect of risk factors on the prevalence of severe AGA., Results: The overall success rate for identifying severe AGA by indirect evaluation of Internet photographs was 94%. The prevalence of severe AGA was 15.33% overall and varied significantly by geographical region. The risk of having severe AGA was increased by 1.092 for every year of age between 30 and 40 years. Severe AGA was more prevalent in subjects with higher body mass index., Conclusions: Photographs from the Internet can be used to evaluate severe AGA in epidemiological studies. The prevalence of severe AGA in young Caucasian men increases with age and varies by geographical region. Body mass index is an environmental risk factor for severe AGA.
- Published
- 2015
- Full Text
- View/download PDF
21. A rare manifestation of Fabry's disease.
- Author
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Nagy ZF, Bencsik K, Rajda C, Morvay M, Husz S, Vörös E, Rolfs A, Honti V, Dobozy A, and Vécsei L
- Subjects
- Adult, Amino Acid Substitution genetics, Fabry Disease genetics, Humans, Male, Paresis genetics, Stroke genetics, alpha-Galactosidase genetics, Fabry Disease pathology, Paresis pathology, Stroke pathology
- Published
- 2007
- Full Text
- View/download PDF
22. Hemochromatosis (HFE) gene mutations and hepatitis C virus infection as risk factors for porphyria cutanea tarda in Hungarian patients.
- Author
-
Nagy Z, Kószó F, Pár A, Emri G, Horkay I, Horányi M, Karádi O, Rumi G Jr, Morvay M, Varga V, Dobozy A, and Mózsik G
- Subjects
- Adult, Aged, Aged, 80 and over, Female, Hemochromatosis complications, Hemochromatosis Protein, Humans, Hungary, Male, Middle Aged, Mutation, Porphyria Cutanea Tarda complications, Porphyria Cutanea Tarda physiopathology, Risk Factors, Hemochromatosis genetics, Hepatitis C complications, Histocompatibility Antigens Class I genetics, Membrane Proteins genetics, Porphyria Cutanea Tarda etiology
- Abstract
Aim: It is not clear whether the mutations in hemochromatosis (HFE) gene and hepatitis C virus (HCV) infection act independently in the pathogenesis of porphyria cutanea tarda (PCT). The prevalence of both risk factors varies greatly in different parts of the world. PCT patients from Hungary were evaluated to assess both factors., Methods: The prevalence of C282Y and H63D mutations in the HFE gene was determined in 50 PCT patients and compared with the reported control frequencies. Furthermore, the presence of HCV infection was determined and related to the patients' HFE gene status., Results: The C282Y mutation was found in 8/50 cases (three homozygotes and five heterozygotes), with an 11% allele frequency (vs. 3.8% control) (P<0.05). Seventeen patients were heterozygous, one was homozygous for the H63D mutation, allele frequency 19%, which did not differ significantly from the reported control prevalence of 12.3%. Twenty-two patients (44%) were HCV-RNA positive; six out of them were heterozygous for H63D mutation, one only for the C282Y mutation and one was compound heterozygous for both mutations., Conclusion: HCV infection and HFE C282Y mutation may probably be independent predisposing factors for development of PCT in Hungarian patients.
- Published
- 2004
- Full Text
- View/download PDF
23. [Are the hemochromatosis (HFE) gene mutation and hepatitis C virus (HCV) infection risk factors for porphyria cutanea tarda?].
- Author
-
Nagy Z, Kószó F, Pár A, Nagy A, Horányi M, Morvay M, Dobozy A, and Mózsik G
- Subjects
- Adult, Aged, Alleles, Female, Genetic Predisposition to Disease, Hepacivirus genetics, Heterozygote, Homozygote, Humans, Hungary, Male, Middle Aged, RNA, Viral blood, Risk Factors, Hemochromatosis genetics, Hepacivirus isolation & purification, Hepatitis C complications, Mutation, Porphyria Cutanea Tarda genetics, Porphyria Cutanea Tarda virology
- Abstract
As it is not clear whether mutations in hemochromatosis gene (HFE) and hepatitis C virus (HCV) act independently in the pathogenesis of porphyria cutanea tarda (PCT), and prevalence of both risk factors reveals a great variety in different parts of the world, PCT patients from our Central East European country were investigated for this aspect. The occurrence of the C282Y and H63D mutations in HFE gene were determined in 19 PCT patients and compared with the reported control frequencies. Furthermore, the presence of HCV infection was determined and related to the patients' HFE status. The C282Y mutation was found in 3/19 cases (one patient was homozygous and two heterozygous), with an 10.5% allele frequency (vs. 3.8% control) (p < 0.05). Five patients were heterozygous for the H63D mutation, allele frequency 13.1%, which did not differ from the reported control prevalence of 12.3%. Six patients (31.7%) were HCV-RNA positive, out of the six one was heterozygous for H63D mutation and one was compound heterozygous. HCV infection and HFE C282Y mutations may probably be independent predisposing factors for development of PCT in Hungarian patients.
- Published
- 2000
24. Novel proline substitution mutations in keratin 16 in two cases of pachyonychia congenita type 1.
- Author
-
Smith FJ, Del Monaco M, Steijlen PM, Munro CS, Morvay M, Coleman CM, Rietveld FJ, Uitto J, and McLean WH
- Subjects
- Cataract genetics, Ectodermal Dysplasia pathology, Female, Humans, Infant, Male, Pedigree, Skin ultrastructure, Ectodermal Dysplasia genetics, Keratins genetics, Mutation, Missense, Nails, Malformed, Proline genetics
- Abstract
Pachyonychia congenita (PC) is a group of inherited ectodermal dysplasias, the characteristic phenotype being hypertrophic nail dystrophy. Two main clinical subtypes, PC-1 and PC-2, are inherited as autosomal dominant disorders, but other less well characterized clinical forms also exist. The PC-1 phenotype may be distinguished by the absence of the epidermal cysts found in PC-2, and it has been shown to be caused by mutations in either keratin K16 or its expression partner, the K6a isoform of K6. Mutations in K16 have also been shown to cause a milder related phenotype, focal non-epidermolytic palmoplantar keratoderma. Recently, we have developed a long-range polymerase chain reaction (PCR) strategy which allows specific amplification of the entire functional K16 gene (KRT16A), without amplification of the two K16 pseudogenes (psiKRT16B and psiKRT16C), enabling mutation analysis based on genomic DNA. Here, using this methodology, we describe novel mutations R127P and Q122P in the helix 1A domain of K16 in two families presenting with PC-1. Both mutations were excluded from 50 normal unrelated individuals by restriction enzyme analysis of K16 PCR fragments. In one family, ultrastructural analysis was performed, revealing distinctive tonofilament abnormalities. Specifically, keratin filament bundles were greatly condensed, but did not form the dense amorphous aggregates seen in a number of other keratin disorders. In the second kindred, autosomal dominant cataract was present in some but not all members affected by PC. As the cataract phenotype did not fully cosegregate with the K16 mutation, and given that K16 is not expressed in the lens, these two phenotypes may be coincidental.
- Published
- 1999
- Full Text
- View/download PDF
25. Scleromyxedema.
- Author
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Bata-Csorgo Z, Husz S, Foldes M, Korom I, Molnar K, Morvay M, and Dobozy A
- Subjects
- Cyclosporine therapeutic use, Fibroblasts pathology, Humans, Immunoglobulin G analysis, Male, Middle Aged, Myositis complications, Paraproteins analysis, Scleroderma, Systemic pathology, Skin pathology, Mucinoses drug therapy, Mucinoses immunology, Mucinoses pathology
- Abstract
Scleromyxedema is a sclerotic variant of papular mucinosis, in which lichenoid papules and scleroderma-like features are present. We describe a patient with scleromyxedema with IgG type lambda chain paraprotein, a systemic sclerosis-like illness, and myositis. The patient's serum contained Scl 70 antibodies, characteristic of scleroderma. Electromyography showed signs of acute myositis and the creatine phosphokinase (CPK) level was elevated. Multiply passaged fibroblasts from the patient's skin lesions showed altered growth response in vitro. The patient was treated with cyclosporin (4 mg/kg/day) with improvement.
- Published
- 1999
- Full Text
- View/download PDF
26. Juvenile pemphigus foliaceus.
- Author
-
Mehravaran M, Morvay M, Molnár K, Oláh J, Korom I, Husz S, and Dobozy A
- Subjects
- Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Autoimmune Diseases drug therapy, Autoimmune Diseases immunology, Child, Dapsone therapeutic use, Female, Fluorescent Antibody Technique, Direct, Glucocorticoids therapeutic use, Humans, Pemphigus drug therapy, Pemphigus immunology, Prednisolone therapeutic use, Autoimmune Diseases pathology, Pemphigus pathology
- Abstract
A 7-year-old girl with generalized erythematous, scaling plaques and vesiculobullous lesions on the extremities was diagnosed as having pemphigus foliaceus. Lesional direct immunofluorescence revealed intercellular IgG, IgA and C3 deposition. The patient's serum gave positive reactions against one epitope of desmoglein 3 and the epitope of desmoglein 1 in enzyme-linked immunosorbent assays, but the blood sample for indirect immunofluorescence did not display any circulating antibodies. The patient was successfully treated systemically with prednisolone and dapsone. Currently, she is taking dapsone, 12.5 mg daily. She has been free of lesions for the last 3 years.
- Published
- 1998
- Full Text
- View/download PDF
27. Hailey-Hailey disease with acrokeratosis verruciformis Hopf.
- Author
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Yakis G, Csató M, Kemény L, Korom I, Morvay M, and Dobozy A
- Subjects
- Acrodermatitis diagnosis, Humans, Keratitis diagnosis, Male, Middle Aged, Pemphigus, Benign Familial diagnosis, Acrodermatitis complications, Keratitis complications, Pemphigus, Benign Familial complications
- Published
- 1996
- Full Text
- View/download PDF
28. [New lasers in dermatologic surgery].
- Author
-
Morvay M
- Subjects
- Forecasting, Humans, Laser Therapy trends, Photosensitivity Disorders, Phototherapy instrumentation, Skin Diseases diagnosis, Dermatology instrumentation, Laser Therapy instrumentation, Lasers classification, Skin Diseases surgery
- Abstract
Developments in the fields of laser technology and application have significantly broadened its clinical use over the past two decades. As lasers became more smaller, more reliable and less expensive, dermatology will benefit new laser-based therapeutic and diagnostic methods. Relevant laser systems and their clinical applications are presented, as are investigational laser systems, which may be of importance for the future in dermatology. We review advances in the use of pulsed lasers for treating vascular and non-vascular, pigmented epidermal and dermal lesions, for precise cutting of tissue, for photodynamic therapy and the future role of diode lasers in dermatological laser surgery is also discussed.
- Published
- 1995
29. [Chronic hemodialysis-related porphyria/pseudoporphyria].
- Author
-
Kószó F, Földes M, Morvay M, Judák R, Vakis G, and Dobozy A
- Subjects
- Female, Humans, Kidney Failure, Chronic metabolism, Male, Uroporphyrinogen Decarboxylase blood, Uroporphyrins blood, Kidney Failure, Chronic therapy, Porphyria Cutanea Tarda etiology, Renal Dialysis adverse effects, Skin Diseases, Vesiculobullous etiology
- Abstract
In a considerable proportion of the patients with chronic renal failure, skin changes resembling porphyria cutanea tarda (PCT) develop some months to years after the onset of maintenance hemodialysis. This can be either real PCT, or secondary PCT, or PCT-like bullous dermatosis. In a minor proportion, real PCT can be diagnosed. In such cases, elevated total porphyrin levels with a predominance of uro- (I > III) and heptacarboxyl porphyrins (III > I) can be measured in the plasma (also in the urine, if not anuric), and fecal (perhaps urinary as well) isocoproporphyrin can be detected. The activity of the hepatic uroporphyrinogen decarboxylase (UD) is decreased in every type of PCT; in PCT-II, also that of the erythrocyte UD. In a higher proportion, secondary PCT (pseudo-PCT) develops. In this group, porphyrins are accumulated in the plasma due to the unsatisfactory renal function. Uro and hepta are the dominant fractions here as well, but alteration in the ratio of the uro isomers or the presence of isocoproporphyrin can not be expected. The UD activity is probably normal in every tissue. In 1% to 18% of the cases, PCT-like bullous dermatoses develop, but porphyrins are at normal levels in all compartments. The phototoxic agent here is other than porphyrin (e.g. nalidixic acid, furosemide, tetracycline, etc., or unknown). The authors review the knowledge on chronic hemodialysis-related PCT or the PCT-like bullous dermatoses: development of the above-mentioned conditions, clinical and morphological and biochemical features, difficulties in diagnosis, or the possibilities in therapy.
- Published
- 1994
30. [Ocular manifestations in porphyria cutanea tarda].
- Author
-
Hammer H, Korom I, Morvay M, and Simon M
- Subjects
- Conjunctiva pathology, Cornea physiopathology, Eye radiation effects, Female, Humans, Male, Porphyria Cutanea Tarda urine, Porphyrins urine, Sunlight, Ultraviolet Rays adverse effects, Eye Diseases etiology, Photosensitivity Disorders etiology, Porphyria Cutanea Tarda complications
- Abstract
Ninety two patients suffering from porphyria cutanea tarda were examined ophthalmologically in a paired case-control study. The incidence of pinguecula and that of pterygium were 8 times and 2 times higher, respectively, in PCT patients that in the control group. The photodamage of the conjunctiva is presumed to be a result of the photoactivity of uroporphyrin in the tissues.
- Published
- 1992
31. Erythrocyte uroporphyrinogen decarboxylase activity in 80 unrelated patients with porphyria cutanea tarda.
- Author
-
Kószó F, Morvay M, Dobozy A, and Simon N
- Subjects
- Adult, Age Factors, Aged, Family, Female, Humans, Male, Middle Aged, Porphyrias blood, Porphyrias classification, Porphyrias genetics, Sex Factors, Erythrocytes enzymology, Porphyrias enzymology, Skin Diseases enzymology, Uroporphyrinogen Decarboxylase blood
- Abstract
To estimate the prevalence of the subgroups of porphyria cutanea tarda (PCT), erythrocyte uroporphyrinogen decarboxylase (UD) activity was measured in 80 unrelated patients with PCT, and in 45 of their relatives by using pentacarboxyl-porphyrinogen III as substrate. The subgroups were differentiated by analysis of the urinary porphyrins of the patients and 119 of their relatives. Of the patients, 77.5% were found to be suffering from the sporadic form of PCT (type I PCT), and 22.5% from the familial form (type II PCT). Every patient with PCT had previously been affected by alcohol, oestrogen or some other liver-damaging factor. The relative frequency of familial PCT was higher in females (nine of 15) than in males (nine of 65), which suggests that inheritance of the gene for type II PCT may predispose to oestrogen-precipitated PCT. The onset of type II PCT occurred at a lower age than that of type I (42.6 vs. 47.0 years). The findings suggest an increased risk of precipitating factors in carriers of an inherited UD deficiency.
- Published
- 1992
- Full Text
- View/download PDF
32. Polygenic heredity of porphyria cutanea tarda.
- Author
-
Hunyadi J, Morvay M, and Dobozy A
- Subjects
- Erythrocytes enzymology, Humans, Porphyrias metabolism, Porphyrias genetics, Skin Diseases genetics
- Published
- 1990
- Full Text
- View/download PDF
33. [Secondary malignant tumor associated with melanoma].
- Author
-
Korom I, Szekeres L, Bertényi C, and Morvay M
- Subjects
- Adult, Aged, Female, Humans, Male, Middle Aged, Carcinoma pathology, Leukemia pathology, Lymphoma pathology, Melanoma pathology, Neoplasms, Multiple Primary
- Published
- 1985
34. [The role of frozen sections in the intraoperative diagnosis of skin cancer].
- Author
-
Korom I, Bertényi C, Kapitány K, Morvay M, and Dobó E
- Subjects
- Carcinoma, Basal Cell diagnosis, Carcinoma, Basal Cell pathology, Diagnosis, Differential, Humans, Intraoperative Period, Melanoma diagnosis, Skin Neoplasms diagnosis, Frozen Sections, Melanoma pathology, Microtomy, Skin Neoplasms pathology
- Published
- 1986
35. [Coexistence of porphyria cutanea tarda and lupus erythematosus].
- Author
-
Morvay M, Hunyadi J, Kószó F, Kiss M, Dobozy A, and Simon N
- Subjects
- Adult, Female, Humans, Lupus Erythematosus, Discoid complications, Lupus Erythematosus, Cutaneous complications, Lupus Erythematosus, Systemic complications, Porphyrias complications, Skin Diseases complications
- Abstract
We report on the appearance of porphyria cutanea tarda in a patient with systemic LE and in two patients with discoid LE. A review is given on the corresponding literature. It is suggested that both lupus erythematosus and porphyria cutanea tarda have multifactorial inheritance. The cause of coexistence can be common genes responsible for the genetic determination which also predispose to the occurrence of both diseases. The question of etiology still remains obscure. This coexistence raises, however, a more practical question as regards the therapeutic modalities for the two diseases.
- Published
- 1989
36. [Porphyria sclerodermiformis].
- Author
-
Simon M, Korom I, Szekeres L, Morvay M, and Kószó F
- Subjects
- Adult, Aged, Female, Humans, Male, Middle Aged, Skin pathology, Porphyrias pathology, Scleroderma, Systemic pathology, Skin Diseases pathology
- Published
- 1986
37. [Skin changes in hemodialysis patients].
- Author
-
Morvay M, Lubach D, Froese P, and Lüth BJ
- Subjects
- Female, Humans, Kidney Failure, Chronic complications, Kidney Failure, Chronic therapy, Long-Term Care, Male, Middle Aged, Renal Dialysis, Skin Diseases etiology
- Abstract
188 patients undergoing long-term hemodialysis and a control group of 371 patients without kidney diseases were examined with regard to changes of the connective tissue of the skin. The following alterations were observed: increased sensibility to low temperatures and Raynaud's syndrome (42%), Dupuytren's contracture (22.4%), sclerosis of the dorsum of the fingers (17.6%). Carpal tunnel syndrome was seen in 24.4% of the cases, significantly correlating with the duration of hemodialysis.
- Published
- 1987
38. [Erythrocyte protoporphyrin studies in hepato-erythropoietic porphyria].
- Author
-
Kószó F, Morvay M, Kiss M, Simon M, Dobozy A, and Varga G
- Subjects
- Aged, Erythrocytes analysis, Erythropoiesis, Female, Humans, Liver Diseases blood, Porphyrias blood, Porphyrins blood, Protoporphyrins blood
- Published
- 1988
39. [Sclerodermiform porphyria].
- Author
-
Simon N, Korom I, Szekeres L, Morvay M, and Kószó F
- Subjects
- Actin Cytoskeleton ultrastructure, Collagen metabolism, Facial Dermatoses pathology, Humans, Microscopy, Electron, Porphyrins urine, Skin pathology, Porphyrias pathology, Scleroderma, Localized pathology, Skin Diseases pathology
- Abstract
We give a retrospective survey on the clinical, histological, biochemical, and pathogenetical aspects of sclerodermiform changes rarely accompanying porphyria cutanea tarda (PCT). Sclerodermiform changes were seen in 12 patients (2% of all our PCT cases). In these patients, no correlation was found between the severity of the dermatological signs and symptoms and the degree of disturbance in the porphyrin metabolism. Biochemical remission was not accompanied by improvement of the sclerodermiform changes. The proportion of porphyrins with 4 or 5 COOH-groups was higher than that of PCT patients without sclerosis. The findings are consistent with the view that the development of sclerodermiform changes cannot be merely explained by phototoxic reactions, but the "dark-effect" of the porphyrins may also play an important role in the pathogenesis.
- Published
- 1986
40. Repigmentation of vitiligo macules treated topically with Efudix cream.
- Author
-
Szekeres E and Morvay M
- Subjects
- Administration, Topical, Adult, Child, Female, Fluorouracil administration & dosage, Humans, Male, Melanocytes ultrastructure, Microscopy, Electron, Middle Aged, Ointments, Skin pathology, Vitiligo pathology, Fluorouracil therapeutic use, Skin Pigmentation drug effects, Vitiligo drug therapy
- Abstract
Repigmentation has been observed under the influence of topically administered Efudix cream in 3 patients with vitiligo of symmetrical acral type. No response has been received in 2 patients with segmental vitiligo treated in the same way. Recurrence of vitiligo was seen in 1 patient. Histologic and electron microscopic characterization of recolonized melanocytes is described. The significance of topical 5-fluorouracil treatment in vitiligo is discussed.
- Published
- 1985
- Full Text
- View/download PDF
41. [Skin changes in hemodialysis patients].
- Author
-
Morvay M and Marghescu S
- Subjects
- Female, Humans, Male, Middle Aged, Risk Factors, Kidney Failure, Chronic therapy, Renal Dialysis, Skin Diseases etiology
- Published
- 1988
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