Author: "M L, Petrelli" - Searchworks@Jio Institute Digital Library Search Results

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Author: G, Teti, G, Mancuso, E, Losi, F, Tomasello, V, Cusumano, M, Gambuzza, and M L, Petrelli
Subjects: Disease Models, Animal, Mice, Mice, Inbred BALB C, Animals, Newborn, Tumor Necrosis Factor-alpha, Streptococcal Infections, Age Factors, Animals, Streptococcus agalactiae
Published: 1997

Author: Francesco Tomasello, Giuseppe Mancuso, M. L. Petrelli, E. Losi, V. Cusumano, Maria Elsa Gambuzza, and Giuseppe Teti
Subjects: business.industry, Age related, Immunology, Toxicity, Medicine, Neonatal mouse, Tumor necrosis factor alpha, Disease, Neonatal age, business, Pathophysiology, Group B
Abstract: Newborns are highly susceptible to infections by group B streptococci (GBS), a relatively infrequent cause of serious disease in adults. Several immunological defects, including decreased opsono-phagocytosis, can, at least partially, account for the increased susceptibility of neonates to GBS infections. We have previously demonstrated that tumor necrosis factor alpha (TNF-α) plays an important pathophysiologic role in neonatal models of GBS disease1. This study was undertaken to test the hypothesis that neonatal age is associated with altered sensitivity to TNF-α-dependent toxic activities of GBS products.
Published: 1997
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