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Introduction: In Portugal, a colorectal cancer screening program based on faecal immunochemical test followed by colonoscopy was shown to be cost-effective for individuals between 50 and 74 years old. We report the first findings of the implementation of a population-based program In Northern Portugal. Material and Methods: In the pilot phase, eligible subjects were allocated either to a direct mailing invitation or to primary care centers. In the first year of program implementation, we assessed the uptake rate, the faecal immunochemical test -positivity rate, the diagnostic yield of advanced neoplasia, and the quality parameters for post-faecal immunochemical test + colonoscopy. Results: We invited 100 501 eligible subjects (49% male with a median age of 55 years). Of these, 5228 participated in the pilot phase and 95 273 participated in the first year of the program. In the first year of the program, the adherence was 29%, with a positivity rate of 5% and a 60% compliance to colonoscopy. The faecal immunochemical test-detection rate of advanced neoplasia was 0.35/1000 subjects, and the positive predictive value at post- faecal immunochemical test + colonoscopy was 44% and 2% for advanced adenoma and invasive cancer, respectively. No major adverse events were reported after colonoscopy. Discussion: The suboptimal adherence to faecal immunochemical test and post-faecal immunochemical test + colonoscopy remains the most urgent step to be addressed. Conclusion: A centralized invitation system based on direct mailing was feasible and both colonoscopy quality and diagnostic yield were adequate antecipating the success of the programme.

On page 168, Table 2, where it reads: On page 168, Table 2, where it reads: Advanced phenotype rate* [n (%)] 35 (49.0) 10 (52.0) 25 (47.0) 0.606 Carcinoma** [n (%)] 2 (2.0) 1 (5.0) 1 (2.0) It should read: Advanced phenotype rate [n (%)] 179 (22.0) 57 (30.0) 35 (21.0) 29 (21.0) 24 (14.0) 34 (24.0) Carcinoma [n (%)] 3 (0.4) 2 1 On page 168, Table 3, where it reads: ADR (%) 80.0 - Advanced adenoma (%) 44.0 15.9 It should read: ADR (%) 41.0 - Advanced adenoma (%) 22.0 15.9 Article published with errors: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/15904

This study analyses the distribution of the total metal(loid)s content accumulated in the sediments of the Grande River, the most important river course that runs through the old mining district of La Carolina (Jaén, Spain), whose waters are collected in an urban supply reservoir. In total, 102 sediments samples were taken along the river, 51 in the live-bed channel and another 51 in the floodplain. The samples analysed have high metal(loid)s content, sometimes much higher than the reference levels established by European and regional legislation for soils, especially Pb, As and Ba, with average values of 5452 mg/kg, 116 mg/kg and 2622 mg/kg, respectively. The statistical analysis of the values obtained allows the distribution of the contents of the different elements along the river to be characterized and the associations and dispersion patterns in the sediments of the metal(loid)s coming from the environmental liabilities of the numerous dumpsites and tailings dams generated by mining activity to be defined. In both cases, the high metal(loid)s content identified as well as the resulting values of various environmental indices (the enrichment factor, contamination factor, geoaccumulation index, potential ecological risk index and pollution load index), confirmed that the sediment samples were moderately to highly contaminated over extensive areas of the basin studied, with the greatest intensity and extent in the floodplain sediments.

The internal geometries of progradational units on the coastal plain in southeastern Spain (Carchuna Beach, Granada) since the maximum Holocene marine transgression (ca. 7000 cal BP) have been analysed using ground-penetrating radar (GPR). Radargram analysis shows the presence of sedimentary structures consistent with the progradation of coastal plains, interpreted as laminations associated with the foreset and topset. Laterally, five middle scale progradational units (H2, H3, H4, H5 and H6) are identified. Each of these units can be grouped into two major units. The general trend towards progradation is interrupted at the boundary of the units. Minor scale units (prograding wedges), deposited at topographically lower areas, are detected in GPR profiles. The radargrams also show channel erosional surfaces and sigmoidal landward dipping reflections interpreted as washover channel deposits, with the erosion and transference of sediments between the beach and the back-ridge domain. Furthermore, the saturation of coastline sediments with saltwater rapidly attenuates the GPR signal. Thus, the GPR is also a good tool to detect saltwater intrusions in shallow aquifers.