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1. Ovarian reserve may influence the outcome of bone mineral density in patients with long-term use of dienogest

Author: N Yamamoto, O Wada-Hiraike, M Hirano, T Hirata, M Harada, Y Hirota, K Koga, T Fujii, and Y Osuga
Subjects: Medicine (General), R5-920
Abstract: Objective: Long-term administration of dienogest, which is known to have effect on bone mineral density, is frequently done in patients with endometriosis and adenomyosis, but a few studies focused on the bone mineral density changes after finishing the long-term therapy. This study aimed to reveal the factors that adversely affect lumbar bone mineral density. Method: Fifty-seven premenopausal women who visited our hospital were diagnosed as either endometriosis or adenomyosis, and they were treated by dienogest for more than 115 weeks (26.5 months). Based on a previous report, bone mineral density changes less than 2% was categorized as the osteopenic group ( n = 30), and the others were assigned to the unchanged group ( n = 27). Bone mineral density was measured at the lumbar spine using dual-energy X-ray absorptiometry. A representative ovarian reserve marker, endogenous estradiol levels, and follicle-stimulating hormone levels were measured over time and were compared between the osteopenic and unchanged groups. Result: Duration of dienogest intake was 59.5 months (osteopenic group) versus 57.5 months (unchanged group). These patients experienced ovarian surgeries in a similar frequency, but the ovarian reserve in osteopenic group was impaired as suggested by the decline of endogenous estradiol level during intake of dienogest compared to that of unchanged group ( p = 0.0146). Endogenous follicle-stimulating hormone level between osteopenic group and unchanged group did not reach statistically significant difference, although the osteopenic group showed relatively higher level. Conclusion: This study might suggest that decreased ovarian reserve as judged by endogenous estradiol level is a factor that negatively affect bone mineral density, and measurement of endogenous estradiol level during intake of dienogest could have a predictive meaning of future decreased bone mineral density level.
Published: 2021
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2. Extracting above-ground biomass in areas corresponding to FAO’s definition of 'Forest' using open geospatial data: Results for ASEAN

Author: B. A. Johnson, C. Umemiya, T. Tadono, M. Harada, O. Ochiai, and K. Hamamoto
Subjects: Technology, Engineering (General). Civil engineering (General), TA1-2040, Applied optics. Photonics, TA1501-1820
Abstract: In this study, we extracted above-ground biomass (AGB) information for forests in different ecological zones of ASEAN (Association of Southeast Asian Nations) by integrating freely-available global AGB, forest, and ecological zone map products. Our objective was to assess the suitability of the data and proposed approach for national reporting of forest carbon stocks. We compared the satellite-derived AGB values of forests in ASEAN countries with the corresponding AGB values provided by the Intergovernmental Panel for Climate Change (IPCC) in their Guidelines for National Greenhouse Gas Inventories (which are derived from ground-based measurements of forest AGB). For this, we used a map integration approach that ensures that AGB data is extracted from areas corresponding to the Food and Agricultural Association (FAO) of the UN’s definitions of “forest” and “ecological zones”, as recommended by the relevant IPCC Guidelines. We found that the average satellite-derived AGB values extracted for each ecological zone were generally lower than the values for natural forests (but higher than the values for plantation forests) provided in the IPCC Guidelines. Further investigation showed that this was partly due to the presence of many erroneously low AGB values for forests in the extracted results, caused by errors in the data masks applied to the original global AGB map, including masks of cropland, urban areas, bare soil, and water bodies. Our findings suggest that further processing is necessary before using satellite-derived data for national reporting of forest carbon stocks in ASEAN countries, and we give a few possible options for this.
Published: 2024
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3. Contrasting responses of summer precipitation to orbital forcing in Japan and China over the past 450 kyr

Author: T. Matsushita, M. Harada, H. Ueda, T. Nakagawa, Y. Kubota, Y. Suzuki, and Y. Kamae
Subjects: Environmental pollution, TD172-193.5, Environmental protection, TD169-171.8, Environmental sciences, GE1-350
Abstract: Understanding orbital-scale changes in East Asian summer monsoon (EASM) precipitation is a fundamental issue in paleoclimate research as it helps assess the response of the East Asian monsoon to different climatic forcings, such as insolation, ice volume, and greenhouse gases. However, due to inconsistencies between different proxies, the fundamental driving force for EASM variability remains controversial. The present study simulated the global climate under given insolation changes over the past 450 kyr using a climate model, version 2.3 of the Meteorological Research Institute's Coupled General Circulation Model (MRI-CGCM2.3). Changes in summer insolation over East Asia resulted in distinct climatic responses in China and Japan: an increase in summer insolation led to increased summer precipitation in China and decreased summer precipitation in Japan. Composite analyses of simulated climate under strong boreal-summer insolation suggest that warming of the Indian Ocean occurs under intense insolation, resulting in the intensification of the North Pacific subtropical high (sub-high). The northern shift in the monsoon front, associated with the intensified sub-high, leads to an increase in rainfall in the coastal area of China. In contrast, the intensity of the EASM around Japan is affected by the strength of the North Pacific High. Under strong insolation, the increase in thermal contrast between the North American continent and the North Pacific Ocean intensifies the North Pacific High, decreasing summer precipitation around Japan. Thus, strong regional differences in the effects of solar-insolation variability on summer precipitation in East Asia exist due to interactions with different ocean basins.
Published: 2024
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4. Survey of in vitro fertilization add-ons in Japan (Izanami project)

Author: N. Shionoya, M. Yamada, S. Harada, H. Shirasawa, S. Chik Jwa, K. Kuroda, M. Harada, and Y. Osuga
Subjects: adoption, cost, in vitro fertilization, add-ons, Japan, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract: ObjectiveTo identify any correlations between evidence levels, adoption rates, and additional costs of in vitro fertilization (IVF) add-ons.DesignOnline survey.SubjectsThe survey was conducted in 621 assisted reproductive technology-registered facilities that are members of the Japanese Society of Obstetrics and Gynecology from December 22, 2021, to February 13, 2022.ExposureThe survey included details regarding the specific add-on modalities employed and their associated costs; inquiries pertained to the fertility healthcare infrastructure in Japan before the implementation of the National Health Insurance scheme.Main outcome measuresThe correlation between the adoption rate and cost of IVF add-ons and their evidence levels were analyzed. The evidence level of the add-on treatments was classified into Green, Amber, and Red categories based on the United Kingdom’s Human Fertilisation and Embryology Authority and Cochrane systematic reviews.ResultsA total of 438 eligible responses were analyzed, with clinics constituting 70.9% of the respondents’ facilities. A total of 18 add-ons were assessed, and 96.5% (423/438) of facilities used at least one add-on. A positive correlation of the adoption rate and an inverse correlation of the cost with the evidence level of the IVF add-on treatment were observed (not significant). Outpatient clinics, defined as medical facilities with no beds, had a significantly higher adoption rate (Amber, 65.7%; Red, 52.0%) of add-ons than other facilities, regardless of the evidence rating, although the costs were similar across all site attributes.ConclusionAccumulating evidence on the efficacy and safety of add-ons will lead to the development of medical care with a high-cost benefit, as an increase in the adoption rate and a decrease in cost are expected when limiting to medical care with a high level of evidence.
Published: 2024
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5. Study on the accidental background of the JSNS $$^2$$ 2 experiment

Author: D. H. Lee, S. Ajimura, M. K. Cheoun, J. H. Choi, J. Y. Choi, T. Dodo, J. Goh, K. Haga, M. Harada, S. Hasegawa, T. Hiraiwa, W. Hwang, H. I. Jang, J. S. Jang, H. Jeon, S. Jeon, K. K. Joo, D. E. Jung, S. K. Kang, Y. Kasugai, T. Kawasaki, E. J. Kim, J. Y. Kim, S. B. Kim, W. Kim, H. Kinoshita, T. Konno, I. T. Lim, C. Little, E. Marzec, T. Maruyama, S. Masuda, S. Meigo, S. Monjushiro, D. H. Moon, T. Nakano, M. Niiyama, K. Nishikawa, M. Y. Pac, H. W. Park, J. S. Park, R. G. Park, S. J. M. Peeters, C. Rott, K. Sakai, S. Sakamoto, T. Shima, C. D. Shin, J. Spitz, F. Suekane, Y. Sugaya, K. Suzuya, M. Taira, Y. Yamaguchi, M. Yeh, I. S. Yeo, C. Yoo, and I. Yu
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract JSNS $$^2$$ 2 (J-PARC Sterile Neutrino Search at J-PARC Spallation Neutron Source) is an experiment that searches for sterile neutrinos via the observation of $$\bar{\nu }_{\mu } \rightarrow \bar{\nu }_{e}$$ ν ¯ μ → ν ¯ e appearance oscillations using muon decay-at-rest neutrinos. The JSNS $$^2$$ 2 experiment performed data taking from 2021. In this manuscript, a study of the accidental background is presented. The rate of the accidental background is ( $$9.29\pm 0.39) \times 10^{-8}$$ 9.29 ± 0.39 ) × 10 - 8 /spill with 0.75 MW beam power and comparable to the expected number of signal events.
Published: 2024
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6. Increased plasma plant sterol levels in heterozygotes with sitosterolemia and xanthomatosis.

Author: H Hidaka, T Nakamura, T Aoki, H Kojima, Y Nakajima, K Kosugi, I Hatanaka, M Harada, M Kobayashi, and A Tamura
Subjects: Biochemistry, QD415-436
Abstract: Plasma sterol levels in a family of sitosterolemia and xanthomatosis were determined by a high performance liquid chromatography. Three affected siblings manifested marked xanthomatosis including subcutaneous soft tissues and generalized atherosclerosis. Two other siblings as well as children of the patients did not show such clinical symptoms and signs. Plasma levels of cholesterol, sitosterol, campesterol, and cholestanol in three affected subjects were 190 +/- 18.5, 25.9 +/- 11.6, 16.1 +/- 7.8, 1.84 +/- 0.92 mg/dl (mean +/- SD), respectively. Four daughters of the affected subjects, who should be considered as obligatory heterozygotes, showed moderately increased levels of these sterols (195 +/- 41.7, 1.33 +/- 0.44, 1.56 +/- 0.69, 0.80 +/- 0.28 mg/dl), which were significantly higher than those of normal subjects. Treatment with cholestyramine had little effect on the increased plasma plant sterol levels, but markedly decreased plasma cholestanol concentrations in two affected siblings. This report presents the clinical features of the patients with sitosterolemia and xanthomatosis and also demonstrates that heterozygotes with this disorder have increased plasma levels of plant sterols as well as cholestanol, and suggests that this rare disease might be inherited as an autosomal co-dominant trait in certain cases. The data also indicate that cholestyramine administration was not effective in this family for treatment of sitosterolemia.
Published: 1990
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7. Combined Pre-supernova Alert System with KamLAND and Super-Kamiokande

Author: S. Abe, M. Eizuka, S. Futagi, A. Gando, Y. Gando, S. Goto, T. Hachiya, K. Hata, K. Ichimura, S. Ieki, H. Ikeda, K. Inoue, K. Ishidoshiro, Y. Kamei, N. Kawada, Y. Kishimoto, M. Koga, M. Kurasawa, T. Mitsui, H. Miyake, D. Morita, T. Nakahata, R. Nakajima, K. Nakamura, R. Nakamura, J. Nakane, H. Ozaki, K. Saito, T. Sakai, I. Shimizu, J. Shirai, K. Shiraishi, R. Shoji, A. Suzuki, A. Takeuchi, K. Tamae, H. Watanabe, K. Watanabe, S. Yoshida, S. Umehara, K. Fushimi, K. Kotera, Y. Urano, B. E. Berger, B. K. Fujikawa, J. G. Learned, J. Maricic, Z. Fu, J. Smolsky, L. A. Winslow, Y. Efremenko, H. J. Karwowski, D. M. Markoff, W. Tornow, S. Dell’Oro, T. O’Donnell, J. A. Detwiler, S. Enomoto, M. P. Decowski, K. M. Weerman, C. Grant, H. Song, A. Li, S. N. Axani, M. Garcia, The KamLAND Collaboration, K. Abe, C. Bronner, Y. Hayato, K. Hiraide, K. Hosokawa, K. Ieki, M. Ikeda, J. Kameda, Y. Kanemura, R. Kaneshima, Y. Kashiwagi, Y. Kataoka, S. Miki, S. Mine, M. Miura, S. Moriyama, M. Nakahata, Y. Nakano, S. Nakayama, Y. Noguchi, K. Sato, H. Sekiya, H. Shiba, K. Shimizu, M. Shiozawa, Y. Sonoda, Y. Suzuki, A. Takeda, Y. Takemoto, H. Tanaka, T. Yano, S. Han, T. Kajita, K. Okumura, T. Tashiro, T. Tomiya, X. Wang, P. Fernandez, L. Labarga, N. Ospina, B. Zaldivar, B. W. Pointon, E. Kearns, J. L. Raaf, L. Wan, T. Wester, J. Bian, N. J. Griskevich, M. B. Smy, H. W. Sobel, V. Takhistov, A. Yankelevich, J. Hill, M. C. Jang, S. H. Lee, D. H. Moon, R. G. Park, B. Bodur, K. Scholberg, C. W. Walter, A. Beauchêne, O. Drapier, A. Giampaolo, Th. A. Mueller, A. D. Santos, P. Paganini, B. Quilain, R. Rogly, T. Nakamura, J. S. Jang, L. N. Machado, K. Choi, N. Iovine, S. Cao, L. H. V. Anthony, D. Martin, N. W. Prouse, M. Scott, Y. Uchida, V. Berardi, N. F. Calabria, M. G. Catanesi, E. Radicioni, A. Langella, G. De Rosa, G. Collazuol, M. Feltre, F. Iacob, M. Mattiazzi, L. Ludovici, M. Gonin, L. Périssé, G. Pronost, C. Fujisawa, S. Horiuchi, M. Kobayashi, Y. M. Liu, Y. Maekawa, Y. Nishimura, R. Okazaki, R. Akutsu, M. Friend, T. Hasegawa, T. Ishida, T. Kobayashi, M. Jakkapu, T. Matsubara, T. Nakadaira, Y. Oyama, K. Sakashita, T. Sekiguchi, T. Tsukamoto, A. Portocarrero Yrey, N. Bhuiyan, G. T. Burton, F. Di Lodovico, J. Gao, A. Goldsack, T. Katori, J. Migenda, R. M. Ramsden, Z. Xie, S. Zsoldos, A. T. Suzuki, Y. Takagi, Y. Takeuchi, H. Zhong, J. Feng, L. Feng, J. R. Hu, Z. Hu, M. Kawaue, T. Kikawa, M. Mori, T. Nakaya, R. A. Wendell, K. Yasutome, S. J. Jenkins, N. McCauley, P. Mehta, A. Tarrant, M. J. Wilking, Y. Fukuda, Y. Itow, H. Menjo, K. Ninomiya, Y. Yoshioka, J. Lagoda, M. Mandal, P. Mijakowski, Y. S. Prabhu, J. Zalipska, M. Jia, J. Jiang, W. Shi, C. Yanagisawa, M. Harada, Y. Hino, H. Ishino, Y. Koshio, F. Nakanishi, S. Sakai, T. Tada, T. Tano, T. Ishizuka, G. Barr, D. Barrow, L. Cook, S. Samani, D. Wark, A. Holin, F. Nova, S. Jung, B. S. Yang, J. Y. Yang, J. Yoo, J. E. P. Fannon, L. Kneale, M. Malek, J. M. McElwee, M. D. Thiesse, L. F. Thompson, S. T. Wilson, H. Okazawa, S. M. Lakshmi, S. B. Kim, E. Kwon, J. W. Seo, I. Yu, A. K. Ichikawa, K. D. Nakamura, S. Tairafune, K. Nishijima, A. Eguchi, K. Nakagiri, Y. Nakajima, S. Shima, N. Taniuchi, E. Watanabe, M. Yokoyama, P. de Perio, S. Fujita, C. Jesús-Valls, K. Martens, K. M. Tsui, M. R. Vagins, J. Xia, S. Izumiyama, M. Kuze, R. Matsumoto, K. Terada, R. Asaka, M. Ishitsuka, H. Ito, Y. Ommura, N. Shigeta, M. Shinoki, K. Yamauchi, T. Yoshida, R. Gaur, V. Gousy-Leblanc, M. Hartz, A. Konaka, X. Li, S. Chen, B. D. Xu, A. Q. Zhang, B. Zhang, M. Posiadala-Zezula, S. B. Boyd, R. Edwards, D. Hadley, M. Nicholson, M. O’Flaherty, B. Richards, A. Ali, B. Jamieson, S. Amanai, Ll. Marti, A. Minamino, R. Shibayama, S. Suzuki, and The Super-Kamiokande Collaboration
Subjects: Particle astrophysics, Neutrino astronomy, Core-collapse supernovae, Astrophysics, QB460-466
Abstract: Preceding a core-collapse supernova (CCSN), various processes produce an increasing amount of neutrinos of all flavors characterized by mounting energies from the interior of massive stars. Among them, the electron antineutrinos are potentially detectable by terrestrial neutrino experiments such as KamLAND and Super-Kamiokande (SK) via inverse beta decay interactions. Once these pre-supernova (pre-SN) neutrinos are observed, an early warning of the upcoming CCSN can be provided. In light of this, KamLAND and SK, both located in the Kamioka mine in Japan, have been monitoring pre-SN neutrinos since 2015 and 2021, respectively. Recently, we performed a joint study between KamLAND and SK on pre-SN neutrino detection. A pre-SN alert system combining the KamLAND detector and the SK detector was developed and put into operation, which can provide a supernova alert to the astrophysics community. Fully leveraging the complementary properties of these two detectors, the combined alert is expected to resolve a pre-SN neutrino signal from a 15 M _⊙ star within 510 pc of the Earth at a significance level corresponding to a false alarm rate of no more than 1 per century. For a Betelgeuse-like model with optimistic parameters, it can provide early warnings up to 12 hr in advance.
Published: 2024
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8. Performance of SK-Gd’s Upgraded Real-time Supernova Monitoring System

Author: Y. Kashiwagi, K. Abe, C. Bronner, Y. Hayato, K. Hiraide, K. Hosokawa, K. Ieki, M. Ikeda, J. Kameda, Y. Kanemura, R. Kaneshima, Y. Kataoka, S. Miki, S. Mine, M. Miura, S. Moriyama, Y. Nakano, M. Nakahata, S. Nakayama, Y. Noguchi, K. Sato, H. Sekiya, H. Shiba, K. Shimizu, M. Shiozawa, Y. Sonoda, Y. Suzuki, A. Takeda, Y. Takemoto, H. Tanaka, T. Yano, S. Han, T. Kajita, K. Okumura, T. Tashiro, T. Tomiya, X. Wang, S. Yoshida, P. Fernandez, L. Labarga, N. Ospina, B. Zaldivar, B. W. Pointon, E. Kearns, J. L. Raaf, L. Wan, T. Wester, J. Bian, N. J. Griskevich, S. Locke, M. B. Smy, H. W. Sobel, V. Takhistov, A. Yankelevich, J. Hill, M. C. Jang, S. H. Lee, D. H. Moon, R. G. Park, B. Bodur, K. Scholberg, C. W. Walter, A. Beauchêne, O. Drapier, A. Giampaolo, Th. A. Mueller, A. D. Santos, P. Paganini, B. Quilain, R. Rogly, T. Nakamura, J. S. Jang, L. N. Machado, J. G. Learned, K. Choi, N. Iovine, S. Cao, L. H. V. Anthony, D. Martin, N. W. Prouse, M. Scott, A. A. Sztuc, Y. Uchida, V. Berardi, M. G. Catanesi, E. Radicioni, N. F. Calabria, A. Langella, G. De Rosa, G. Collazuol, F. Iacob, M. Mattiazzi, L. Ludovici, M. Gonin, L. Périssé, G. Pronost, C. Fujisawa, Y. Maekawa, Y. Nishimura, R. Okazaki, R. Akutsu, M. Friend, T. Hasegawa, T. Ishida, T. Kobayashi, M. Jakkapu, T. Matsubara, T. Nakadaira, K. Nakamura, Y. Oyama, K. Sakashita, T. Sekiguchi, T. Tsukamoto, N. Bhuiyan, G. T. Burton, F. Di Lodovico, J. Gao, A. Goldsack, T. Katori, J. Migenda, R. M. Ramsden, Z. Xie, S. Zsoldos, A. T. Suzuki, Y. Takagi, Y. Takeuchi, H. Zhong, J. Feng, L. Feng, J. R. Hu, Z. Hu, M. Kawaue, T. Kikawa, M. Mori, T. Nakaya, R. A. Wendell, K. Yasutome, S. J. Jenkins, N. McCauley, P. Mehta, A. Tarrant, Y. Fukuda, Y. Itow, H. Menjo, K. Ninomiya, Y. Yoshioka, J. Lagoda, S. M. Lakshmi, M. Mandal, P. Mijakowski, Y. S. Prabhu, J. Zalipska, M. Jia, J. Jiang, C. K. Jung, W. Shi, M. J. Wilking, C. Yanagisawa, M. Harada, Y. Hino, H. Ishino, Y. Koshio, F. Nakanishi, S. Sakai, T. Tada, T. Tano, T. Ishizuka, G. Barr, D. Barrow, L. Cook, S. Samani, D. Wark, A. Holin, F. Nova, S. Jung, B. S. Yang, J. Y. Yang, J. Yoo, J. E. P. Fannon, L. Kneale, M. Malek, J. M. McElwee, M. D. Thiesse, L. F. Thompson, S. T. Wilson, H. Okazawa, S. B. Kim, E. Kwon, J. W. Seo, I. Yu, A. K. Ichikawa, K. D. Nakamura, S. Tairafune, K. Nishijima, A. Eguchi, K. Nakagiri, Y. Nakajima, S. Shima, N. Taniuchi, E. Watanabe, M. Yokoyama, P. de Perio, S. Fujita, C. Jesús-Valls, K. Martens, K. M. Tsui, M. R. Vagins, J. Xia, M. Kuze, S. Izumiyama, R. Matsumoto, M. Ishitsuka, H. Ito, Y. Ommura, N. Shigeta, M. Shinoki, K. Yamauchi, T. Yoshida, R. Gaur, V. Gousy-Leblanc, M. Hartz, A. Konaka, X. Li, S. Chen, B. D. Xu, B. Zhang, M. Posiadala-Zezula, S. B. Boyd, R. Edwards, D. Hadley, M. Nicholson, M. O’Flaherty, B. Richards, A. Ali, B. Jamieson, S. Amanai, Ll. Marti, A. Minamino, S. Suzuki, and The Super-Kamiokande Collaboration
Subjects: Core-collapse supernovae, Supernova neutrinos, Particle astrophysics, Astrophysics, QB460-466
Abstract: Among multimessenger observations of the next Galactic core-collapse supernova, Super-Kamiokande (SK) plays a critical role in detecting the emitted supernova neutrinos, determining the direction to the supernova (SN), and notifying the astronomical community of these observations in advance of the optical signal. In 2022, SK has increased the gadolinium dissolved in its water target (SK-Gd) and has achieved a Gd concentration of 0.033%, resulting in enhanced neutron detection capability, which in turn enables more accurate determination of the supernova direction. Accordingly, SK-Gd’s real-time supernova monitoring system has been upgraded. SK_SN Notice, a warning system that works together with this monitoring system, was released on 2021 December 13, and is available through GCN Notices. When the monitoring system detects an SN-like burst of events, SK_SN Notice will automatically distribute an alarm with the reconstructed direction to the supernova candidate within a few minutes. In this paper, we present a systematic study of SK-Gd’s response to a simulated Galactic SN. Assuming a supernova situated at 10 kpc, neutrino fluxes from six supernova models are used to characterize SK-Gd’s pointing accuracy using the same tools as the online monitoring system. The pointing accuracy is found to vary from 3° to 7° depending on the models. However, if the supernova is closer than 10 kpc, SK_SN Notice can issue an alarm with three-degree accuracy, which will benefit follow-up observations by optical telescopes with large fields of view.
Published: 2024
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9. Search for Astrophysical Electron Antineutrinos in Super-Kamiokande with 0.01% Gadolinium-loaded Water

Author: M. Harada, K. Abe, C. Bronner, Y. Hayato, K. Hiraide, K. Hosokawa, K. Ieki, M. Ikeda, J. Kameda, Y. Kanemura, R. Kaneshima, Y. Kashiwagi, Y. Kataoka, S. Miki, S. Mine, M. Miura, S. Moriyama, Y. Nakano, M. Nakahata, S. Nakayama, Y. Noguchi, K. Okamoto, K. Sato, H. Sekiya, H. Shiba, K. Shimizu, M. Shiozawa, Y. Sonoda, Y. Suzuki, A. Takeda, Y. Takemoto, A. Takenaka, H. Tanaka, S. Watanabe, T. Yano, S. Han, T. Kajita, K. Okumura, T. Tashiro, T. Tomiya, X. Wang, S. Yoshida, G. D. Megias, P. Fernandez, L. Labarga, N. Ospina, B. Zaldivar, B. W. Pointon, E. Kearns, J. L. Raaf, L. Wan, T. Wester, J. Bian, N. J. Griskevich, S. Locke, M. B. Smy, H. W. Sobel, V. Takhistov, A. Yankelevich, J. Hill, S. H. Lee, D. H. Moon, R. G. Park, B. Bodur, K. Scholberg, C. W. Walter, A. Beauchêne, O. Drapier, A. Giampaolo, Th. A. Mueller, A. D. Santos, P. Paganini, B. Quilain, T. Ishizuka, T. Nakamura, J. S. Jang, J. G. Learned, K. Choi, N. Iovine, S. Cao, L. H. V. Anthony, D. Martin, M. Scott, A. A. Sztuc, Y. Uchida, V. Berardi, M. G. Catanesi, E. Radicioni, N. F. Calabria, A. Langella, L. N. Machado, G. De Rosa, G. Collazuol, F. Iacob, M. Lamoureux, M. Mattiazzi, L. Ludovici, M. Gonin, G. Pronost, C. Fujisawa, Y. Maekawa, Y. Nishimura, R. Okazaki, R. Akutsu, M. Friend, T. Hasegawa, T. Ishida, T. Kobayashi, M. Jakkapu, T. Matsubara, T. Nakadaira, K. Nakamura, Y. Oyama, K. Sakashita, T. Sekiguchi, T. Tsukamoto, N. Bhuiyan, G. T. Burton, F. Di Lodovico, J. Gao, A. Goldsack, T. Katori, J. Migenda, Z. Xie, S. Zsoldos, Y. Kotsar, H. Ozaki, A. T. Suzuki, Y. Takagi, Y. Takeuchi, J. Feng, L. Feng, J. R. Hu, Z. Hu, T. Kikawa, M. Mori, T. Nakaya, R. A. Wendell, K. Yasutome, S. J. Jenkins, N. McCauley, P. Mehta, A. Tarrant, Y. Fukuda, Y. Itow, H. Menjo, K. Ninomiya, J. Lagoda, S. M. Lakshmi, M. Mandal, P. Mijakowski, Y. S. Prabhu, J. Zalipska, M. Jia, J. Jiang, C. K. Jung, M. J. Wilking, C. Yanagisawa, Y. Hino, H. Ishino, H. Kitagawa, Y. Koshio, F. Nakanishi, S. Sakai, T. Tada, T. Tano, G. Barr, D. Barrow, L. Cook, S. Samani, D. Wark, A. Holin, F. Nova, B. S. Yang, J. Y. Yang, J. Yoo, J. E. P. Fannon, L. Kneale, M. Malek, J. M. McElwee, M. D. Thiesse, L. F. Thompson, S. T. Wilson, H. Okazawa, S. B. Kim, E. Kwon, J. W. Seo, I. Yu, A. K. Ichikawa, K. D. Nakamura, S. Tairafune, K. Nishijima, K. Nakagiri, Y. Nakajima, S. Shima, N. Taniuchi, E. Watanabe, M. Yokoyama, P. de Perio, K. Martens, K. M. Tsui, M. R. Vagins, J. Xia, M. Kuze, S. Izumiyama, R. Matsumoto, M. Ishitsuka, H. Ito, T. Kinoshita, Y. Ommura, N. Shigeta, M. Shinoki, T. Suganuma, K. Yamauchi, J. F. Martin, H. A. Tanaka, T. Towstego, R. Gaur, V. Gousy-Leblanc, M. Hartz, A. Konaka, X. Li, N. W. Prouse, S. Chen, B. D. Xu, B. Zhang, M. Posiadala-Zezula, S. B. Boyd, R. Edwards, D. Hadley, M. Nicholson, M. O’Flaherty, B. Richards, A. Ali, B. Jamieson, Ll. Marti, A. Minamino, G. Pintaudi, S. Sano, S. Suzuki, K. Wada, and The Super-Kamiokande Collaboration
Subjects: Supernova neutrinos, Neutrino astronomy, Astrophysics, QB460-466
Abstract: We report the first search result for the flux of astrophysical electron antineutrinos for energies ${ \mathcal O }(10)\,\mathrm{MeV}$ in the gadolinium-loaded Super-Kamiokande (SK) detector. In 2020 June, gadolinium was introduced to the ultrapure water of the SK detector in order to detect neutrons more efficiently. In this new experimental phase, SK-Gd, we can search for electron antineutrinos via inverse beta decay with efficient background rejection thanks to the high efficiency of the neutron tagging technique. In this paper, we report the result for the initial stage of SK-Gd, during 2020 August 26, and 2022 June 1 with a 22.5 × 552 kton · day exposure at 0.01% Gd mass concentration. No significant excess over the expected background in the observed events is found for the neutrino energies below 31.3 MeV. Thus, the flux upper limits are placed at the 90% confidence level. The limits and sensitivities are already comparable with the previous SK result with pure water (22.5 × 2970 kton · day) owing to the enhanced neutron tagging. Operation with Gd increased to 0.03% started in 2022 June.
Published: 2023
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10. 2023 Update on European Atherosclerosis Society Consensus Statement on Homozygous Familial Hypercholesterolaemia: new treatments and clinical guidance

Author: M, Cuchel, primary, FJ, Raal, additional, RA, Hegele, additional, K, Al-Rasadi, additional, M, Arca, additional, M, Averna, additional, E, Bruckert, additional, T, Freiberger, additional, D, Gaudet, additional, M, Harada-Shiba, additional, LC, Hudgins, additional, M, Kayikcioglu, additional, L, Masana, additional, KG, Parhofer, additional, JE, Roeters van Lennep, additional, RD, Santos, additional, ESG, Stroes, additional, GF, Watts, additional, A, Wiegman, additional, JK, Stock, additional, LS, Tokgozoğlu, additional, AL, Catapano, additional, and KK, Ray, additional
Published: 2023
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11. Informing COVID-19 Response and Health Equity Agenda: Collection of Public Health Reports Articles on Emerging Viral Epidemics in the United States, 1878-2021

Author: Noelle M. Harada, Andrey Kuzmichev, Zygmunt F. Dembek, Amy I. Ising, and Hazel D. Dean
Subjects: Public Health, Environmental and Occupational Health
Abstract: Objective: Public Health Reports ( PHR) is the oldest public health journal in the United States and has reported on viral epidemics since the 19th century. We describe the creation and analysis of a collection of historic PHR articles on emerging viral epidemics in the United States to inform public health response to COVID-19 and future epidemics. Methods: We searched databases from 1878 through 2021 using custom search strings and conducted a manual search for articles published under previously used names for PHR. We evaluated all articles based on inclusion/exclusion criteria and coded the final list for virus/disease, article type, public health emergency preparedness and response capabilities from the Centers for Disease Control and Prevention (CDC), and PubMed citation count. Results: We identified 349 relevant articles including 130 commentaries/reviews/editorials, 79 epidemiologic reports, 75 research articles, and 65 case study/practice articles. The collection focused on influenza (n = 244), COVID-19 (n = 75), dengue (n = 14), and other emerging viruses, such as Zika and Ebola (n = 25). The collection included 48 articles on health disparities/health of various disadvantaged populations, highlighting such disparities as race and ethnicity (n = 22), socioeconomic status (n = 17), and age (n = 15). When we categorized articles by CDC public health emergency preparedness and response capabilities, we found that 207 addressed surveillance and epidemiologic investigation, 36 addressed community preparedness, and 28 addressed medical countermeasure dispensing and administration. The articles addressing surveillance and epidemiologic investigation, nonpharmaceutical interventions, and community preparedness had the most PubMed citations (799, 334, and 308, respectively). Conclusions: PHR’s historic articles on US emerging viral epidemics covered a range of virus/disease types, emergency preparedness and response capabilities, and contribution types and were widely cited in the scholarly literature. This publicly available and continuously updated collection is a valuable resource for pandemic planning and response.
Published: 2023

12. Experimental validation of cold neutron source performance with mesitylene moderator installed at RANS

Author: Yujiro Ikeda, Makoto Teshigawara, Mingfei Yan, Chihiro Iwamoto, Kunihiro Fujita, Yutaka Abe, Yasuo Wakabayashi, Atsushi Taketani, Takaoki Takanashi, M. Harada, Takao Hashiguchi, Yutaka Yamagata, Yoshio Matsuzaki, Baolong Ma, Masato Takamura, Maki Mizuta, Makoto Goto, Shota Ikeda, Tomohiro Kobayashi, and Yoshie Otake
Subjects: Nuclear and High Energy Physics, Nuclear Energy and Engineering
Abstract: The RANS (RIKEN Accelerator driven Neutron Source), one of compact accelerator neutron sources (CANS), tries to expand its performance by installing a cold neutron which may provide new opportunities in many applications. RANS is a low power CANS with a proton beam of 7 MeV and 100 µA at maximum. A moderator system was constructed based on results of optimization design study with mesitylene. Recently, we have done performance tests aiming at showing characteristics as cold neutron source. Cryogenic mesitylene moderator was installed on a plug with a new target moderator reflector configuration of RANS. Experiment using a gas electron multiplier (GEM) detector was carried out to measure neutron spectra of the cold moderator. This paper describes performance of the cold moderator in terms of 1) Cold neutron gain of optimization design with respect to a polyethylene moderator, 2) Temperature dependency of cold neutron spectrum flux regarding scattering kernel (SK), and 3) comparison between experiment and calculation. A note is given for comparison between calculations with different SKs available. Also, two-dimensional imaging of cold and thermal neutron spectrum flux on the viewed surface is shown with a pinhole slit configuration.
Published: 2023

13. Implementation of a low-activation Au-In-Cd decoupler into the J-PARC 1 MW short pulsed spallation neutron source

Author: M. Teshigawara, Y. Ikeda, M. Ooi, M. Harada, H. Takada, M. Kakishiro, G. Noguchi, T. Shimada, K. Seita, D. Murashima, K. Fukatani, K. Kanomata, and T. Teraoku
Subjects: 1 MW short pulsed spallation neutron source, Decoupler, Neutron absorber, Gold-indium-cadmium (Au-In-Cd) alloy, Silver-indium-cadmium (Ag-In-Cd) alloy, Hot isostatic pressing (HIP), Moderator-reflector assembly, Ultrasonic transmission, Aluminum alloy (A5083), ANSYS code, Nuclear engineering. Atomic power, TK9001-9401
Abstract: A silver-indium-cadmium (Ag-In-Cd, or AIC) alloy with a 1 eV high neutron cut-off energy was originaly developed as a decoupler to provide a narrow neutron pulse width with a short tail for the J-PARC 1-MW short-pulsed spallation neutron source. As a result of later studies, gold (Au) was chosen as a substitute for Ag for the production of spare decoupled moderators and reflector in order to reduce residual radioactivity thus easing handling and disposal of the spent moderator and reflector. The decoupler material Au-In-Cd (AuIC) was therefore investigated and developed. To implement it into an actual moderator-reflector assembly many critical engineering issues needed to be resolved with regard to large-sized bonding between AuIC and aluminum alloy A5083 by the hot isostatic pressing process (HIP). The HIP process for AuIC and aluminum was investigated in terms of surface condition, size, and heat capacity. Implementation of an AuIC decoupler into a spare reflector assembly was successfuly achieved and will result in a remarkable reduction of radioactivity compared to AIC without sacrificing neutronic performance.
Published: 2018
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14. Development of laminate materials with low Df using novel functionalized PPE

Author: H. Yamamoto, K. Iwase, H. Fukuoka, S. Otani, and M. Harada
Published: 2023

15. Liquid crystal mesogenic epoxy modified cyanate ester resin

Author: S. Yanaura and M. Harada
Published: 2023

16. Association of touch experiences in childhood with social touch resistance and attachment in adulthood

Author: M., Harada and Emiko, Katsurada
Published: 2022

17. WCN23-0309 RELATIONSHIP BETWEEN ORAL HEALTH STATUS AND PHYSICAL FUNCTION IN PATIENTS UNDERGOING HEMODIALYSIS: A CROSS-SECTIONAL STUDY

Author: S. Nikkawa, K. Imamura, S. Yoshikoshi, T. Nakajima, J. Uchida, N. Fukuzaki, A. Tobita, M. Harada, S. Osada, and A. Matsunaga
Subjects: Nephrology
Published: 2023

18. TSV process solution for 3D-IC.

Author: Satoru Toyoda, A. Shibata, M. Harada, Takahide Murayama, Toshiyuki Sakuishi, M. Hatanaka, Yasuhiro Morikawa, and Koukou Suu
Published: 2011
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19. Supernova model discrimination with hyper-kamiokande

Author: Y. Nagao, H. Tanaka, A. Minamino, B. Navarro-Garcia, Z. Xie, L. Nascimento Machado, J. Lagoda, M. Shinoki, S. Cuen-Rochin, Arman Esmaili, F. Ballester, S. Parsa, N. McCauley, Jung-Hyun Kim, K. Frankiewicz, L. L. Kormos, Masaki Ishitsuka, M. Malek, V. Valentino, N. Kazarian, T. Wachala, E. Drakopoulou, G. Grella, V. Paolone, L. F. Thompson, A. K. Tomatani-Sánchez, A. Blanchet, R. A. Wendell, John Ellis, J. Y. Kim, N. W. Prouse, O. V. Mineev, M. R. Vagins, T. Boschi, T. Lindner, J. González-Nuevo, Hiroshi Ito, N. Skrobova, M. La Commara, L. Gialanella, F. Orozco-Luna, T. Kumita, A. Garfagnini, S. H. Jeon, A. Dergacheva, Hiroaki Menjo, A. T. Suzuki, K. Okamoto, C. E. R. Naseby, J. F. Martin, T. Iijima, M. Mezzetto, G. Ricciardi, J. R. Wilson, P. Gumplinger, Y. Takemoto, G. Galinski, K. Zaremba, T. Nakadaira, D. Vivolo, A. Carroll, C. Vilela, A. Blondel, A. Rychter, T. A. Doyle, C. Garde, G. De Rosa, A. Oshlianskyi, Hiroyuki Sekiya, R. Matsumoto, G. Pastuszak, P. J. Rajda, F. Monrabal, Yoichi Asaoka, G. Díaz López, K. L. Stankevich, C. D. Shin, Y. Fukuda, Yuto Ashida, Michal Malinský, T. Suganuma, B. Radics, Kohta Murase, Marco Grassi, P. Mehta, F. Cafagna, Ahmed Ali, L. Koerich, Vincenzo Berardi, Etam Noah, F. J. P. Soler, Alan Cosimo Ruggeri, M. Kekic, G. Vasseur, S. Wronka, M. Thiesse, B. Ferrazzi, K. Iwamoto, Yu. Kudenko, Atsushi Takeda, Kendall Mahn, David Hadley, B. Roskovec, M. Bergevin, A. Korzenev, J.J. Gómez-Cadenas, M. Batkiewicz-Kwasniak, M. Tzanov, M. Ikeda, Federico Sanchez, W. Obrębski, H. S. Jo, Y. Takeuchi, Piotr Kalaczyński, S. Chakraborty, J. C. Nugent, S. King, P. Paganini, M. Miura, F. Ameli, D. N. Yeum, C. J. Metelko, Akito Araya, T. Kajita, M. Tanaka, I. T. Lim, L. Mellet, S. Y. Kim, S. Bolognesi, A. Bravar, J. S. Jang, D. Svirida, A. Fiorentini, J. Renner, M. Chabera, L. O'Sullivan, V. Herrero, F. Iacob, K. Nakamura, Ko Okumura, Lukasz Stawarz, N. Ogawa, Laura Bonavera, Y. Maekawa, Takatomi Yano, Ll. Marti, H. J. Rose, S. El Hedri, L. Maret, G. Zarnecki, L. Bernard, S. H. Seo, H. Nakamura, H. Ozaki, A. P. Kryukov, A. Popov, Hisakazu Minakata, M. Buizza Avanzini, P. Sarmah, K. Martens, Sergio Luis Suárez Gómez, Hiroaki Aihara, V. Lezaun, G. A. Cowan, C. Riccio, S. Garode, R. Akutsu, M. Lamers James, T. Nicholls, I. Alekseev, K. Kowalik, J. Kasperek, T. Zakrzewski, S. B. Kim, T. Kutter, Evan O'Connor, B. Jamieson, F. Nova, M. Barbi, Xianguo Lu, Y. Sonoda, M. Friend, Teppei Katori, L. H. V. Anthony, A. Shaikhiev, C. J. Densham, V. Gousy-Leblanc, I. Bandac, J. H. Choi, S. Sano, A. K. Ichikawa, Magda Cicerchia, S. Valder, S. Roth, J. Kameda, M. Zito, A. Vijayvargi, S. Nakai, Y. Kotsar, K. M. Tsui, K. Hoshina, K. K. Joo, C. Pastore, T. Marchi, K. Niewczas, K. Nakayoshi, G. Fiorillo, C. McGrew, P. F. Loverre, S. Playfer, G.D. Barr, L. Labarga, T. Kobayashi, E. S. Pinzon Guerra, André Rubbia, D. Karlen, Th. A. Mueller, L. Koch, F. J. Mora, M. M. Khabibullin, Hidekazu Kakuno, Yoshitaka Itow, H. K. Tanaka, P. Adrich, Jeong-Eun Lee, S. Samani, M. G. Catanesi, M. Yu, M. J. Wilking, Robert Svoboda, P. Mijakowski, N. Kolev, Yu. Onishchuk, A. Kato, J. M. Poutissou, C. Bronner, Yutaka Nakajima, B. Richards, C. Ruggles, M. Needham, P. Jonsson, Y. Hayato, S. Mine, A. Konaka, L. Munteanu, Kunio Inoue, O. Drapier, Kenneth Long, M. McCarthy, T. Kinoshita, G. Tortone, Yuuki Nakano, T. Feusels, N. Izumi, Reetanjali Moharana, T. Dealtry, S. Hassani, G. Pronost, K. Sakashita, J. G. Learned, H. M. O'Keeffe, Shintaro Ito, E. Rondio, Toru Ogitsu, D. A. Patel, Tatiana Ovsiannikova, M. Guigue, Yusuke Koshio, T. Matsubara, S. M. Stellacci, R. J. Wilkes, G. Santucci, S. Y. Suzuki, S. D. Rountree, K. Zietara, A. A. Quiroga, M. Jakkapu, A. Boiano, L. Berns, M. O. Wascko, M. M. Vyalkov, K. Porwit, M. Taani, A. Evangelisti, I. Sashima, Michal Dziewiecki, J. Feng, Y. Seiya, M. Yonenaga, B. Spisso, B. W. Pointon, C. M. Mollo, N. Booth, S. V. Cao, N. Ospina, A. J. Finch, V. Takhistov, E. Radicioni, P. Przewlocki, S. Nakayama, S. Yen, T. Sekiguchi, Yudai Suwa, J. M. Calvo-Mozota, S. Zsoldos, C. Checchia, M. Posiadala-Zezula, E. O'Sullivan, Janusz Marzec, F. Retiere, Jan T. Sobczyk, P. Migliozzi, S. Borjabad, I. Di Palma, John Hill, K. A. Kouzakov, D. L. Wark, L. Cook, D. Sgalaberna, E. W. Miller, M. Lamoureux, M. Y. Pac, S. Russo, S. L. Cartwright, Yasunari Suzuki, D. Bose, B. Zaldivar, D. Martin, Dongsu Ryu, Z. Shan, S. Miki, M. Jiang, J. Kisiel, N. Yershov, M. Matusiak, C. Pea-Garay, K. Sato, Jesús Daniel Santos, Y. Yamaguchi, D. Bravo-Berguo, Chad Finley, T. Tashiro, Lawrence D. Brown, A. Gorin, Hiromasa Tanaka, M. Ziembicki, T. Vladisavljevic, J. Zalipska, J. Insler, C. Yanagisawa, Abinash Medhi, L. Kravchuk, W. Idrissi Ibnsalih, Hirokazu Ishino, J. Bian, K. Magar, S. Cebrian, Philippe Mermod, R. Gornea, Juan Pedro Ochoa-Ricoux, Sergei Fedotov, S. Izumiyama, C. Bozza, R. Esteve, Seiko Hirota, T. Tsukamoto, K. Skwarczynski, E. De la Fuente, T. Kikawa, M. Gonin, J. Xia, Intae Yu, Gareth J. Barker, A. Marinelli, E. Kearns, L. Lavitola, Michal Ostrowski, N. Deshmukh, Y. Kataoka, F. d. M. Blaszczyk, Carsten Rott, C. Mariani, T. Ishida, Roberto Spina, J. W. Seo, Masashi Yokoyama, F. Gramegna, K. Hultqvist, G. Collazuol, P. Spradlin, Gus Sinnis, A. Takenaka, T. Xin, M. Bellato, Yuki Fujii, Mark Scott, J. A. Hernando-Morata, P. Ferrario, A. Buchowicz, S. J. Jenkins, J. Walker, J. Toledo, Pablo Fernandez, Sandhya Choubey, S. Emery, A. Mefodiev, R.P. Kurjata, M. Mongelli, J. Dumarchez, Tsuyoshi Nakaya, M. Antonova, M. Danilov, M. Feely, A. Holin, Ara Ioannisian, B. A. Popov, K Stopa, W. G. S. Vinning, M. L. Sánchez, Masato Shiozawa, L. Ludovici, J. Gao, S. Bhadra, Koji Ishidoshiro, Hiroshi Nunokawa, V. Aushev, M. Hartz, I. Shimizu, C. S. Moon, M. B. Smy, S. Matsuno, I. Anghel, J. Migenda, T. Mondal, F. Di Lodovico, M. Tada, D. J. Payne, M. Kuze, N. C. Hastings, P. Di Meo, Y. Nishimura, M. Inomoto, L. Magaletti, C. Giganti, A. Klekotko, Patrick Dunne, J. Yoo, M. C. Sanchez, A. N. Khotjantsev, Kyujin Kwak, Lars Eklund, M. Lawe, A. Mitra, H. W. Sobel, Jürgen Pozimski, Yasuhiro Makida, A. Bubak, Jaroslaw Pasternak, B. Quilain, R. Leitner, Marco Laveder, J. P. Coleman, N. F. Calabria, H. I. Jang, S. B. Boyd, Moon Moon Devi, M. Fitton, M. Harada, Artur F. Izmaylov, J. McElwee, Shunsaku Horiuchi, P. de Perio, K. Nakagiri, Y. Kano, M. Rescigno, S. Moriyama, Masayuki Nakahata, C. Pidcott, Y. Uchida, V. Palladino, A. Longhin, A. Shaykina, Michelangelo Pari, Akimichi Taketa, Yuichi Oyama, S. Suvorov, R. P. Litchfield, D. H. Moon, Katsuki Hiraide, M. Pavin, M. Koga, R. B. Vogelaar, Enrique Fernandez-Martinez, B. L. Hartfiel, Koji Yamamoto, K. Ohta, K. Abe, Alexander Studenikin, E. Mazzucato, Elisa Bernardini, Abe, K., Adrich, P., Aihara, H., Akutsu, R., Alekseev, I., Ali, A., Ameli, F., Anghel, I., Anthony, L. H. V., Antonova, M., Araya, A., Asaoka, Y., Ashida, Y., Aushev, V., Ballester, F., Bandac, I., Barbi, M., Barker, G. J., Barr, G., Batkiewicz-Kwasniak, M., Bellato, M., Berardi, V., Bergevin, M., Bernard, L., Bernardini, E., Berns, L., Bhadra, S., Bian, J., Blanchet, A., Blaszczyk, F. D. M., Blondel, A., Boiano, A., Bolognesi, S., Bonavera, L., Booth, N., Borjabad, S., Boschi, T., Bose, D., Boyd, S. B., Bozza, C., Bravar, A., Bravo-Berguo, D., Bronner, C., Brown, L., Bubak, A., Buchowicz, A., Buizza Avanzini, M., Cafagna, F. S., Calabria, N. F., Calvo-Mozota, J. M., Cao, S., Cartwright, S. L., Carroll, A., Catanesi, M. G., Cebrian, S., Chabera, M., Chakraborty, S., Checchia, C., Choi, J. H., Choubey, S., Cicerchia, M., Coleman, J., Collazuol, G., Cook, L., Cowan, G., Cuen-Rochin, S., Danilov, M., Diaz Lopez, G., De La Fuente, E., De Perio, P., De Rosa, G., Dealtry, T., Densham, C. J., Dergacheva, A., Deshmukh, N., Devi, M. M., Di Lodovico, F., Di Meo, P., Di Palma, I., Doyle, T. A., Drakopoulou, E., Drapier, O., Dumarchez, J., Dunne, P., Dziewiecki, M., Eklund, L., El Hedri, S., Ellis, J., Emery, S., Esmaili, A., Esteve, R., Evangelisti, A., Feely, M., Fedotov, S., Feng, J., Fernandez, P., Fernandez-Martinez, E., Ferrario, P., Ferrazzi, B., Feusels, T., Finch, A., Finley, C., Fiorentini, A., Fiorillo, G., Fitton, M., Frankiewicz, K., Friend, M., Fujii, Y., Fukuda, Y., Galinski, G., Gao, J., Garde, C., Garfagnini, A., Garode, S., Gialanella, L., Giganti, C., Gomez-Cadenas, J. J., Gonin, M., Gonzalez-Nuevo, J., Gorin, A., Gornea, R., Gousy-Leblanc, V., Gramegna, F., Grassi, M., Grella, G., Guigue, M., Gumplinger, P., Hadley, D. R., Harada, M., Hartfiel, B., Hartz, M., Hassani, S., Hastings, N. C., Hayato, Y., Hernando-Morata, J. A., Herrero, V., Hill, J., Hiraide, K., Hirota, S., Holin, A., Horiuchi, S., Hoshina, K., Hultqvist, K., Iacob, F., Ichikawa, A. K., Idrissi Ibnsalih, W., Iijima, T., Ikeda, M., Inomoto, M., Inoue, K., Insler, J., Ioannisian, A., Ishida, T., Ishidoshiro, K., Ishino, H., Ishitsuka, M., Ito, H., Ito, S., Itow, Y., Iwamoto, K., Izmaylov, A., Izumi, N., Izumiyama, S., Jakkapu, M., Jamieson, B., Jang, H. I., Jang, J. S., Jenkins, S. J., Jeon, S. H., Jiang, M., Jo, H. S., Jonsson, P., Joo, K. K., Kajita, T., Kakuno, H., Kameda, J., Kano, Y., Kalaczynski, P., Karlen, D., Kasperek, J., Kataoka, Y., Kato, A., Katori, T., Kazarian, N., Kearns, E., Khabibullin, M., Khotjantsev, A., Kikawa, T., Kekic, M., Kim, J. H., Kim, J. Y., Kim, S. B., Kim, S. Y., King, S., Kinoshita, T., Kisiel, J., Klekotko, A., Kobayashi, T., Koch, L., Koga, M., Koerich, L., Kolev, N., Konaka, A., Kormos, L. L., Koshio, Y., Korzenev, A., Kotsar, Y., Kouzakov, K. A., Kowalik, K. L., Kravchuk, L., Kryukov, A. P., Kudenko, Y., Kumita, T., Kurjata, R., Kutter, T., Kuze, M., Kwak, K., La Commara, M., Labarga, L., Lagoda, J., Lamers James, M., Lamoureux, M., Laveder, M., Lavitola, L., Lawe, M., Learned, J. G., Lee, J., Leitner, R., Lezaun, V., Lim, I. T., Lindner, T., Litchfield, R. P., Long, K. R., Longhin, A., Loverre, P., Lu, X., Ludovici, L., Maekawa, Y., Magaletti, L., Magar, K., Mahn, K., Makida, Y., Malek, M., Malinsky, M., Marchi, T., Maret, L., Mariani, C., Marinelli, A., Martens, K., Marti, L., Martin, J. F., Martin, D., Marzec, J., Matsubara, T., Matsumoto, R., Matsuno, S., Matusiak, M., Mazzucato, E., Mccarthy, M., Mccauley, N., Mcelwee, J., Mcgrew, C., Mefodiev, A., Medhi, A., Mehta, P., Mellet, L., Menjo, H., Mermod, P., Metelko, C., Mezzetto, M., Migenda, J., Migliozzi, P., Mijakowski, P., Miki, S., Miller, E. W., Minakata, H., Minamino, A., Mine, S., Mineev, O., Mitra, A., Miura, M., Moharana, R., Mollo, C. M., Mondal, T., Mongelli, M., Monrabal, F., Moon, D. H., Moon, C. S., Mora, F. J., Moriyama, S., Mueller, T. A., Munteanu, L., Murase, K., Nagao, Y., Nakadaira, T., Nakagiri, K., Nakahata, M., Nakai, S., Nakajima, Y., Nakamura, K., Nakamura, K. I., Nakamura, H., Nakano, Y., Nakaya, T., Nakayama, S., Nakayoshi, K., Nascimento Machado, L., Naseby, C. E. R., Navarro-Garcia, B., Needham, M., Nicholls, T., Niewczas, K., Nishimura, Y., Noah, E., Nova, F., Nugent, J. C., Nunokawa, H., Obrebski, W., Ochoa-Ricoux, J. P., O'Connor, E., Ogawa, N., Ogitsu, T., Ohta, K., Okamoto, K., O'Keeffe, H. M., Okumura, K., Onishchuk, Y., Orozco-Luna, F., Oshlianskyi, A., Ospina, N., Ostrowski, M., O'Sullivan, E., O'Sullivan, L., Ovsiannikova, T., Oyama, Y., Ozaki, H., Pac, M. Y., Paganini, P., Palladino, V., Paolone, V., Pari, M., Parsa, S., Pasternak, J., Pastore, C., Pastuszak, G., Patel, D. A., Pavin, M., Payne, D., Pea-Garay, C., Pidcott, C., Pinzon Guerra, E., Playfer, S., Pointon, B. W., Popov, A., Popov, B., Porwit, K., Posiadala-Zezula, M., Poutissou, J. -M., Pozimski, J., Pronost, G., Prouse, N. W., Przewlocki, P., Quilain, B., Quiroga, A. A., Radicioni, E., Radics, B., Rajda, P. J., Renner, J., Rescigno, M., Retiere, F., Ricciardi, G., Riccio, C., Richards, B., Rondio, E., Rose, H. J., Roskovec, B., Roth, S., Rott, C., Rountree, S. D., Rubbia, A., Ruggeri, A. C., Ruggles, C., Russo, S., Rychter, A., Ryu, D., Sakashita, K., Samani, S., Sanchez, F., Sanchez, M. L., Sanchez, M. C., Sano, S., Santos, J. D., Santucci, G., Sarmah, P., Sashima, I., Sato, K., Scott, M., Seiya, Y., Sekiguchi, T., Sekiya, H., Seo, J. W., Seo, S. H., Sgalaberna, D., Shaikhiev, A., Shan, Z., Shaykina, A., Shimizu, I., Shin, C. D., Shinoki, M., Shiozawa, M., Sinnis, G., Skrobova, N., Skwarczynski, K., Smy, M. B., Sobczyk, J., Sobel, H. W., Soler, F. J. P., Sonoda, Y., Spina, R., Spisso, B., Spradlin, P., Stankevich, K. L., Stawarz, L., Stellacci, S. M., Stopa, K., Studenikin, A. I., Suarez Gomez, S. L., Suganuma, T., Suvorov, S., Suwa, Y., Suzuki, A. T., Suzuki, S. Y., Suzuki, Y., Svirida, D., Svoboda, R., Taani, M., Tada, M., Takeda, A., Takemoto, Y., Takenaka, A., Taketa, A., Takeuchi, Y., Takhistov, V., Tanaka, H., Tanaka, H. A., Tanaka, H. I., Tanaka, M., Tashiro, T., Thiesse, M., Thompson, L. F., Toledo, J., Tomatani-Sanchez, A. K., Tortone, G., Tsui, K. M., Tsukamoto, T., Tzanov, M., Uchida, Y., Vagins, M. R., Valder, S., Valentino, V., Vasseur, G., Vijayvargi, A., Vilela, C., Vinning, W. G. S., Vivolo, D., Vladisavljevic, T., Vogelaar, R. B., Vyalkov, M. M., Wachala, T., Walker, J., Wark, D., Wascko, M. O., Wendell, R. A., Wilkes, R. J., Wilking, M. J., Wilson, J. R., Wronka, S., Xia, J., Xie, Z., Xin, T., Yamaguchi, Y., Yamamoto, K., Yanagisawa, C., Yano, T., Yen, S., Yershov, N., Yeum, D. N., Yokoyama, M., Yonenaga, M., Yoo, J., Yu, I., Yu, M., Zakrzewski, T., Zaldivar, B., Zalipska, J., Zaremba, K., Zarnecki, G., Ziembicki, M., Zietara, K., Zito, M., Zsoldos, S., Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Hyper-Kamiokande, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Physics - Instrumentation and Detectors, 09.- Desarrollar infraestructuras resilientes, promover la industrialización inclusiva y sostenible, y fomentar la innovación, KAMIOKANDE, Astrophysics, 01 natural sciences, neutrino: flux, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), neutrino, accretion, black hole, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Core-collapse supernovae, neutron star, Monte Carlo, physics.ins-det, 010303 astronomy & astrophysics, astro-ph.HE, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, Instrumentation and Detectors (physics.ins-det), 16. Peace & justice, Supernova, neutrino: detector, 07.- Asegurar el acceso a energías asequibles, fiables, sostenibles y modernas para todos, supernova, neutrino astronomy, neutrino physics, Neutrino detector, Neutrino, Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, supernova: collapse, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Observable universe, Astrophysics::Cosmology and Extragalactic Astrophysics, Hyper-Kamiokande, 0103 physical sciences, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], High energy physics, Instrumentation and Methods for Astrophysics (astro-ph.IM), High Energy Astrophysical Phenomena, Astrophysics::Galaxy Astrophysics, hep-ex, 010308 nuclear & particles physics, supernova: model, Astronomy and Astrophysics, Galaxy, Black hole, Neutron star, Space and Planetary Science, neutrino: burst, galaxy, Neutrino astronomy, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], astro-ph.IM
Abstract: Autorzy: Abe K., Adrich P., Aihara H., Akutsu, R., Alekseev I., Ali A. , Ameli F., Anghel I., Anthony L. H. V., Antonova M. , Araya A., Asaoka Y., Ashida Y., Aushev V., Ballester F., Bandac I., Barbi M., Barker G. J., Barr G., Batkiewicz-Kwasniak M., Bellato M., Berardi V., Bergevin M., Bernard L., Bernardini E., Berns L., Bhadra S., Bian J., Blanchet A., Blaszczyk F. d. M., Blonde A., Boiano A., Bolognesi S., Bonavera L., Booth N., Borjabad S., Boschi, T., Bose D., Boyd S . B., Bozza C., Bravar A., Bravo-Berguño D., Bronner C., Brown L., Bubak Arkadiusz, Buchowicz A., Buizza Avanzini M., Cafagna F. S., Calabria N. F., Calvo-Mozota J. M., Cao S., Cartwright S.L., Carroll A., Catanesi M. G., Cebriàn, S., Chabera M., Chakraborty, S., Checchia C., Choi J.H., Choubey S., Cicerchia M., Coleman J., Collazuol G., Cook L., Cowan G., Cuen-Rochin, S., Danilov M., Díaz López G., De la Fuente E., de Perio P., De Rosa G., Dealtry T., Densham C. J., Dergacheva A., Deshmukh N., Devi M. M., Di Lodovico F., Di Meo, P., Di Palma I., Doyle T. A., Drakopoulou E., Drapier O., Dumarchez J., Dunne P., Dziewiecki M., Eklund L., El Hedri S., Ellis J., Emery S., Esmaili A., Esteve R., Evangelisti A., Feely M., Fedotov S., Feng J., Fernandez P., Fernández-Martinez E., Ferrario P., Ferrazzi,B., Feusels T., Finch A., Finley C., Fiorentini A., Fiorillo G., Fitton M., Frankiewicz K., Friend M., Fujii Y., Fukuda Y., Galinski G., Gao J., Garde C., Garfagnini A., Garode S., Gialanella L., Giganti C., Gomez-Cadenas J.J., Gonin M., González-Nuevo J., Gorin A., Gornea R., Gousy-Leblanc V. Gramegna F. Grassi M. Grella G. Guigue M. Gumplinger P. Hadley D.R. Harada M., Hartfiel B., Hartz M., Hassani S., Hastings N.C., Hayato Y., Hernando-Morata J.A., Herrero V., Hill J., Hiraide K., Hirota S., Holin A., Horiuchi S., Hoshina K., Hultqvist K., Iacob F., Ichikawa A.K., Idrissi Ibnsalih W., Iijima T., Ikeda M., Inomoto M., Inoue K., Insler J., Ioannisian A., Ishida T., Ishidoshiro K., Ishino H., Ishitsuka M., Ito H., Ito S., Itow Y., Iwamoto K., Izmaylov A., Izumi N., Izumiyama S., Jakkapu M., Jamieson B., Jang H.I., Jang J.S., Jenkins S.J., Jeon S.H., Jiang M., Jo H.S., Jonsson P., Joo K.K., Kajita T., Kakuno H., Kameda J., Kano Y., Kalaczynski P., Karlen D., Kasperek J., Kataoka Y., Kato A., Katori T., Kazarian N., Kearns E., Khabibullin M., Khotjantsev A., Kikawa T., Kekic M., Kim J.H., Kim J.Y., Kim S.B., Kim S.Y., King S., Kinoshita T., Kisiel Jan, Klekotko A., Kobayashi T., Koch L., Koga M., Koerich L., Kolev N., Konaka A., Kormos L.L., Koshio Y., Korzenev A., Kotsar Y., Kouzakov K.A., Kowalik K.L., Kravchuk L., Kryukov A.P., Kudenko Y., Kumita T., Kurjata R., Kutter T., Kuze M., Kwak K., La Commara M., Labarga L., Lagoda J., Lamers James J., Lamoureux M., Laveder M., Lavitola L., Lawe M., Learned J.G., Lee J., Leitner R., Lezaun V., Lim I.T., Lindner T., Litchfield R.P., Long K.R., Longhin A., Loverre P., Lu X., Ludovici L., Maekawa Y., Magaletti L., Magar K., Mahn K., Makida Y., Malek M., Malinský M., Marchi T., Maret L., Mariani C., Marinelli A., Martens K., Marti L., Martin J.F. Martin D., Marzec J., Matsubara T., Matsumoto R., Matsuno S., Matusiak M., Mazzucato E., McCarthy M., McCauley N., McElwee J., McGrew C., Mefodiev A., Medhi A., Mehta P., Mellet L., Menjo H., Mermod P., Metelko C., Mezzetto M., Migenda J., Migliozzi P., Mijakowski P., Miki S., Miller E.W., Minakata H., Minamino A., Mine S., Mineev O., Mitra A., Miura M., Moharana R., Mollo C.M., Mondal T., Mongelli M., Monrabal F., Moon D.H., Moon C.S., Mora F.J., Moriyama S., Mueller Th.A., Munteanu L., Murase K., Nagao Y., Nakadaira T., Nakagiri K., Nakahata M., Nakai S., Nakajima Y., Nakamura K., Nakamura KI., Nakamura H., Nakano Y., Nakaya T., Nakayama S., Nakayoshi K., Nascimento Machado L., Naseby C.E.R., Navarro-Garcia B., Needham M., Nicholls T., Niewczas K., Nishimura Y., Noah E., Nova F., Nugent J.C., Nunokawa H., Obrebski W., Ochoa-Ricoux J.P., O’Connor E., Ogawa N., Ogitsu T., Ohta K., Okamoto K., O’Keeffe H.M., Okumura K., Onishchuk Y., Orozco-Luna F., Oshlianskyi A., Ospina N., Ostrowski M., O’Sullivan E., O’Sullivan L., Ovsiannikova T., Oyama Y., Ozaki H., Pac M.Y., Paganini P., Palladino V., Paolone V., Pari M., Parsa S., Pasternak J., Pastore C., Pastuszak G., Patel D.A., Pavin M., Payne D., Peña-Garay C., Pidcott C., Pinzon Guerra E., Playfer S., Pointon B.W., Popov A., Popov B., Porwit Kamil, Posiadala-Zezula M., Poutissou J.M., Pozimski J., Pronost G., Prouse N.W., Przewlocki P., Quilain B., Quiroga A.A., Radicioni E., Radics B., Rajda P.J., Renner J., Rescigno M., Retiere F., Ricciardi G., Riccio C., Richards B., Rondio E., Rose H.J., Roskovec B., Roth S., Rott C., Rountree S.D., Rubbia A., Ruggeri A.C., Ruggles C., Russo S., Rychter A., Ryu D., Sakashita K., Samani S., Sánchez F., Sánchez M.L., Sanchez M.C., Sano S., Santos J.D., Santucci G., Sarmah P., Sashima I., Sato K., Scott M., Seiya Y., Sekiguchi T., Sekiya H., Seo J.W., Seo S.H., Sgalaberna D., Shaikhiev A., Shan Z., Shaykina A., Shimizu I., Shin C.D., Shinoki M., Shiozawa M., Sinnis G., Skrobova N., Skwarczynski K., Smy M.B., Sobczyk J., Sobel H.W., Soler F. J. P., Sonoda Y., Spina R., Spisso B., Spradlin B., Stankevich K.L., Stawarz L., Stellacci S.M., Stopa K., Studenikin A.I., Suárez Gómez S.L., Suganuma T., Suvorov S., Suwa Y., Suzuki A.T., Suzuki S.Y., Suzuki Y., Svirida D., Svoboda R., Taani M., Tada M., Takeda A., Takemoto Y., Takenaka A., Taketa A., Takeuchi Y., Takhistov V., Tanaka H., Tanaka H.A., Tanaka H.I., Tanaka M., Tashiro T., Thiesse M., Thompson L.F., Toledo J., Tomatani-Sánchez A.K., Tortone G., Tsui K.M., Tsukamoto T., Tzanov M., Uchida Y., Vagins M.R., Valder S., Valentino V., Vasseur G., Vijayvargi A., Vilela C., Vinning W. G. S., Vivolo D., Vladisavljevic T., Vogelaar R.B., Vyalkov M.M., Wachala T., Walker J., Wark D., Wascko M.O., Wendell R.A., Wilkes R.J., Wilking M.J., Wilson M.R., Wronka S., Xia J., Xie Z., Xin T., Yamaguchi Y., Yamamoto K., Yanagisawa C., Yano T., Yen S., Yershov N., Yeum D.N., Yokoyama M., Yonenaga M., Yoo J., Yu I., Yu M., Zakrzewski T., Zaldivar B., Zalipska J., Zaremba K., Zarnecki G., Ziembicki M., Zietara K., Zito M., Zsoldos S., Core-collapse supernovae are among the most magnificent events in the observable universe. They produce many of the chemical elements necessary for life to exist and their remnants-neutron stars and black holes-are interesting astrophysical objects in their own right. However, despite millennia of observations and almost a century of astrophysical study, the explosion mechanism of core-collapse supernovae is not yet well understood. Hyper-Kamiokande is a next-generation neutrino detector that will be able to observe the neutrino flux from the next galactic core-collapse supernova in unprecedented detail. We focus on the first 500 ms of the neutrino burst, corresponding to the accretion phase, and use a newly-developed, high-precision supernova event generator to simulate Hyper-Kamiokandeʼs response to five different supernova models. We show that Hyper-Kamiokande will be able to distinguish between these models with high accuracy for a supernova at a distance of up to 100 kpc. Once the next galactic supernova happens, this ability will be a powerful tool for guiding simulations toward a precise reproduction of the explosion mechanism observed in nature.
Published: 2022

20. P-610 Endoplasmic reticulum stress-induced Notch signaling stimulates cumulus-oocyte complex expansion in PCOS

Author: H Koike, M Harada, C Kunitomi, A Kusamoto, Z Xu, T Tanaka, Y Urata, and Y Osuga
Subjects: Reproductive Medicine, Rehabilitation, Obstetrics and Gynecology
Abstract: Study question Does endoplasmic reticulum (ER) stress and Notch signaling affect cumulus-oocyte complex (COC) expansion in pathophysiology of polycystic ovary syndrome (PCOS)? Summary answer Notch signaling is induced via activation of ER stress in granulosa cells (GCs) of PCOS and stimulates COC expansion that is abrogated by Notch inhibition. What is known already PCOS presents a variety of symptoms including ovarian dysfunction which is caused by various local factors in follicular microenvironment; among them, ER stress and following activation of unfolded protein response are critical, causing ovarian fibrosis, growth arrest of antral follicles and other ovarian dysfunctions. While Notch signaling pathway plays an important role of various ovarian functions such as ovarian development, follicle growth, luteinization and steroid hormone synthesis, the potential interaction between Notch signaling and ER stress in ovarian function is not determined. Study design, size, duration To examine expression levels of Notch signaling, ovaries and granulosa-lutein cells (GLCs) were collected from PCOS patients undergoing surgery or IVF. Human GLCs were collected from follicular fluid of IVF patients and cultured under ER-stressed condition. COCs obtained from PMSG-primed mice were subjected to examine the in vitro effects of ER stress activation and Notch inhibition on COC expansion. To examine the in vivo effects of Notch inhibition, dehydroepiandrosterone-induced PCOS mouse model was used. Participants/materials, setting, methods The expression levels of Notch signaling in ovaries and GLCs were investigated by immunohistochemistry and real time qPCR. To examine whether Notch signaling is activated by ER stress, human GLCs were incubated with ER stress inducer or inhibitor and ATF4 was knocked down by RNA interference. To investigate COC expansion level, murine COCs were cultured under ER stress condition with/without Notch signaling inhibitor. The COCs were collected from PCOS mice treated with/without Notch inhibitor. Main results and the role of chance We found that the expression levels of Notch2 and Hey2, a transcription factor activated by Notch signaling, were upregulated in GCs of antral follicles from PCOS patients and PCOS mice by using immunohistochemical analysis. Similarly, mRNA levels of these genes were higher in GLCs from PCOS patients than those from control patients. Notch signaling was induced in cultured human GLCs incubated with an ER stress inducer, tunicamycin; the effect was abrogated by incubation with an ER stress inhibitor, tauroursodeoxycholic acid (TUDCA), or knockdown of activating transcription factor 4 (ATF4, a transcription factor induced by ER stress). These findings suggest that Notch signaling is induced by ER stress via ATF4 pathway in human GCs. Measuring under a microscope, the area of expanded COCs was increased in cultured murine COCs incubated with tunicamycin, while this stimulatory effect of tunicamycin was abrogated by adding a Notch signaling inhibitor, DAPT. The area of expanded COCs obtained from PCOS model mice was increased compared to control mice, while administration of DAPT to these mice reduced the area. These results suggest that ER stress-induced Notch signaling stimulate COC expansion contributing PCOS pathophysiology. Limitations, reasons for caution COC expansion area was measured only in PCOS model mouse; it is unknown whether COC expansion is induced in PCOS patients. This point requires further investigation in PCOS patients. Wider implications of the findings Our findings suggest that ER stress-induced Notch signaling affects COC expansion, associated with ovulatory dysfunction in PCOS. The detailed understandings of PCOS pathophysiology may be beneficial for substantial clinical implications and inhibition of ER stress or Notch signaling may serve as a novel therapeutic approach for PCOS. Trial registration number This study was supported by Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (JSPS) (19k09749, 19k24045, 19k24021, 21k16808, 21j12871,), a grant from the Takeda Science Foundation, a grant from The Tokyo Society of Medical Science, a grant from The Japan Society of Fertility Preservation, and a grant from The Japan Society for Menopause and Women’s Health (JMWH) (a JMWH Bayer Grant).
Published: 2022

21. Search for supernova bursts in Super-Kamiokande IV

Author: M. Mori, K. Abe, Y. Hayato, K. Hiraide, K. Ieki, M. Ikeda, S. Imaizumi, J. Kameda, Y. Kanemura, R. Kaneshima, Y. Kashiwagi, Y. Kataoka, S. Miki, S. Mine, M. Miura, S. Moriyama, Y. Nagao, M. Nakahata, Y. Nakano, S. Nakayama, Y. Noguchi, T. Okada, K. Okamoto, A. Orii, K. Sato, H. Sekiya, H. Shiba, K. Shimizu, M. Shiozawa, Y. Sonoda, Y. Suzuki, A. Takeda, Y. Takemoto, A. Takenaka, H. Tanaka, T. Tomiya, S. Watanabe, T. Yano, S. Yoshida, S. Han, T. Kajita, K. Okumura, T. Tashiro, X. Wang, J. Xia, G. D. Megias, D. Bravo-Berguño, P. Fernandez, L. Labarga, N. Ospina, B. Zaldivar, S. Zsoldos, B. W. Pointon, F. D. M. Blaszczyk, E. Kearns, J. L. Raaf, J. L. Stone, L. Wan, T. Wester, J. Bian, N. J. Griskevich, W. R. Kropp, S. Locke, M. B. Smy, H. W. Sobel, V. Takhistov, Yankelevich A., J. Hill, J. Y. Kim, I. T. Lim, R. G. Park, B. Bodur, K. Scholberg, C. W. Walter, L. Bernard, A. Coffani, O. Drapier, S. El Hedri, A. Giampaolo, Th. A. Mueller, P. Paganini, B. Quilain, A. D. Santos, T. Ishizuka, T. Nakamura, J. S. Jang, J. G. Learned, L. H. V. Anthony, D. Martin, M. Scott, A. A. Sztuc, Y. Uchida, V. Berardi, M. G. Catanesi, E. Radicioni, N. F. Calabria, L. N. Machado, G. De Rosa, G. Collazuol, F. Iacob, M. Lamoureux, M. Mattiazzi, L. Ludovici, M. Gonin, G. Pronost, Y. Maekawa, Y. Nishimura, C. Fujisawa, M. Friend, T. Hasegawa, T. Ishida, T. Kobayashi, M. Jakkapu, T. Matsubara, T. Nakadaira, K. Nakamura, Y. Oyama, K. Sakashita, T. Sekiguchi, T. Tsukamoto, H. Ozaki, T. Shiozawa, A. T. Suzuki, Y. Takeuchi, S. Yamamoto, Y. Kotsar, Y. Ashida, C. Bronner, J. Feng, S. Hirota, T. Kikawa, T. Nakaya, R. A. Wendell, K. Yasutome, N. McCauley, P. Mehta, K. M. Tsui, Y. Fukuda, Y. Itow, H. Menjo, K. Ninomiya, T. Niwa, M. Tsukada, J. Lagoda, S. M. Lakshmi, P. Mijakowski, J. Zalipska, M. Mandal, Y. S. Prabhu, J. Jiang, C. K. Jung, C. Vilela, M. J. Wilking, C. Yanagisawa, M. Jia, K. Hagiwara, M. Harada, T. Horai, H. Ishino, S. Ito, H. Kitagawa, Y. Koshio, W. Ma, F. Nakanishi, N. Piplani, S. Sakai, G. Barr, D. Barrow, L. Cook, S. Samani, D. Wark, F. Nova, T. Boschi, J. Gao, A. Goldsack, T. Katori, F. Di Lodovico, J. Migenda, M. Taani, J. Y. Yang, S. J. Jenkins, M. Malek, J. M. McElwee, O. Stone, M. D. Thiesse, L. F. Thompson, H. Okazawa, S. B. Kim, J. W. Seo, I. Yu, K. Nishijima, M. Koshiba, K. Nakagiri, Y. Nakajima, K. Iwamoto, N. Taniuchi, M. Yokoyama, K. Martens, P. de Perio, M. R. Vagins, M. Kuze, S. Izumiyama, T. Yoshida, M. Inomoto, M. Ishitsuka, H. Ito, T. Kinoshita, R. Matsumoto, K. Ohta, Y. Ommura, N. Shigeta, M. Shinoki, T. Suganuma, K. Yamauchi, J. F. Martin, H. A. Tanaka, T. Towstego, R. Akutsu, V. Gousy-Leblanc, M. Hartz, A. Konaka, N. W. Prouse, S. Chen, B. D. Xu, B. Zhang, M. Posiadala-Zezula, D. Hadley, M. Nicholson, M. O’Flaherty, B. Richards, A. Ali, B. Jamieson, J. Walker, Ll. Marti, A. Minamino, G. Pintaudi, R. Sasaki, S. Sano, S. Suzuki, K. Wada, S. Cao, A. ichikawa, K. D. Nakamura, S. Tairafune, K. Choi, Mori, M., Abe, K., Hayato, Y., Hiraide, K., Ieki, K., Ikeda, M., Imaizumi, S., Kameda, J., Kanemura, Y., Kaneshima, R., Kashiwagi, Y., Kataoka, Y., Miki, S., Mine, S., Miura, M., Moriyama, S., Nagao, Y., Nakahata, M., Nakano, Y., Nakayama, S., Noguchi, Y., Okada, T., Okamoto, K., Orii, A., Sato, K., Sekiya, H., Shiba, H., Shimizu, K., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Takenaka, A., Tanaka, H., Tomiya, T., Watanabe, S., Yano, T., Yoshida, S., Han, S., Kajita, T., Okumura, K., Tashiro, T., Wang, X., Xia, J., Megias, G. D., Bravo-Bergu??o, D., Fernandez, P., Labarga, L., Ospina, N., Zaldivar, B., Zsoldos, S., Pointon, B. W., Blaszczyk, F. D. M., Kearns, E., Raaf, J. L., Stone, J. L., Wan, L., Wester, T., Bian, J., Griskevich, N. J., Kropp, W. R., Locke, S., Smy, M. B., Sobel, H. W., Takhistov, V., A., Yankelevich, Hill, J., Kim, J. Y., Lim, I. T., Park, R. G., Bodur, B., Scholberg, K., Walter, C. W., Bernard, L., Coffani, A., Drapier, O., El Hedri, S., Giampaolo, A., Mueller, Th. A., Paganini, P., Quilain, B., Santos, A. D., Ishizuka, T., Nakamura, T., Jang, J. S., Learned, J. G., Anthony, L. H. V., Martin, D., Scott, M., Sztuc, A. A., Uchida, Y., Berardi, V., Catanesi, M. G., Radicioni, E., Calabria, N. F., Nascimento Machado, L., De Rosa, G., Collazuol, G., Iacob, F., Lamoureux, M., Mattiazzi, M., Ludovici, L., Gonin, M., Pronost, G., Maekawa, Y., Nishimura, Y., Fujisawa, C., Friend, M., Hasegawa, T., Ishida, T., Kobayashi, T., Jakkapu, M., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Ozaki, H., Shiozawa, T., Suzuki, A. T., Takeuchi, Y., Yamamoto, S., Kotsar, Y., Ashida, Y., Bronner, C., Feng, J., Hirota, S., Kikawa, T., Nakaya, T., Wendell, R. A., Yasutome, K., Mccauley, N., Mehta, P., Tsui, K. M., Fukuda, Y., Itow, Y., Menjo, H., Ninomiya, K., Niwa, T., Tsukada, M., Lagoda, J., Lakshmi, S. M., Mijakowski, P., Zalipska, J., Mandal, M., Prabhu, Y. S., Jiang, J., Jung, C. K., Vilela, C., Wilking, M. J., Yanagisawa, C., Jia, M., Hagiwara, K., Harada, M., Horai, T., Ishino, H., Ito, S., Kitagawa, H., Koshio, Y., Ma, W., Nakanishi, F., Piplani, N., Sakai, S., Barr, G., Barrow, D., Cook, L., Samani, S., Wark, D., Nova, F., Boschi, T., Gao, J., Goldsack, A., Katori, T., Di Lodovico, F., Migenda, J., Taani, M., Yang, J. Y., Jenkins, S. J., Malek, M., Mcelwee, J. M., Stone, O., Thiesse, M. D., Thompson, L. F., Okazawa, H., Kim, S. B., Seo, J. W., Yu, I., Nishijima, K., Koshiba, M., Nakagiri, K., Nakajima, Y., Iwamoto, K., Taniuchi, N., Yokoyama, M., Martens, K., de Perio, P., Vagins, M. R., Kuze, M., Izumiyama, S., Yoshida, T., Inomoto, M., Ishitsuka, M., Ito, H., Kinoshita, T., Matsumoto, R., Ohta, K., Ommura, Y., Shigeta, N., Shinoki, M., Suganuma, T., Yamauchi, K., Martin, J. F., Tanaka, H. A., Towstego, T., Akutsu, R., Gousy-Leblanc, V., Hartz, M., Konaka, A., Prouse, N. W., Chen, S., Xu, B. D., Zhang, B., Posiadala-Zezula, M., Hadley, D., Nicholson, M., O???flaherty, M., Richards, B., Ali, A., Jamieson, B., Walker, J., Marti, Ll., Minamino, A., Pintaudi, G., Sasaki, R., Sano, S., Suzuki, S., Wada, K., Cao, S., Ichikawa, A., Nakamura, K. D., Tairafune, S., and Choi, K.
Subjects: High Energy Astrophysical Phenomena (astro-ph.HE), Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astronomy and Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, High Energy Physics - Experiment, Supernova neutrinos, High Energy Physics - Experiment (hep-ex), Space and Planetary Science, Core-collapse supernovae Supernova neutrinos Particle astrophysics, Core-collapse supernovae, Particle astrophysics, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics::Galaxy Astrophysics
Abstract: Super-Kamiokande has been searching for neutrino bursts characteristic of core-collapse supernovae continuously, in real time, since the start of operations in 1996. The present work focuses on detecting more distant supernovae whose event rate may be too small to trigger in real time, but may be identified using an offline approach. The analysis of data collected from 2008 to 2018 found no evidence of distant supernovae bursts. This establishes an upper limit of 0.29 yr−1 on the rate of core-collapse supernovae out to 100 kpc at 90% C.L. For supernovae that fail to explode and collapse directly to black holes the limit reaches to 300 kpc.
Published: 2022

22. PLANNING PROCESS OF PILOT BATCH PRODUCTION OF AN INNOVATIVE DRUG FOR CLINICAL TRIAL IN A PHARMACEUTICAL INDUSTRY

Author: Lila M. Harada and Adriano Manicoba da Silva
Subjects: Drug development, Pilot batch, Production planning, Clinical trial supply, Production management. Operations management, TS155-194
Abstract: Purpose – Clinical trials are the most critical step in the process of drug development and evaluation to bring a new drug to market. The purpose of this article was to show an approach of the planning and production of a new innovative drug for a clinical study, based on the presentation of decision-making process in a national pharmaceutical industry. Design / methodology / approach - Through a case-study methodology, it was described the pilot batch production planning of a new drug for clinical trial, focusing on how the company evaluates the adequacy of the available systems at the manufacturing plant and how they use them in drug production planning process. Findings – A previous planning for clinical trial supplies production is determinant to decide the order, amount and timing of the products to be produced when the manufacturing plant is shared with the production of commercial products. Also, even in a small pilot batch production, there is a substantial waste of supplies during the process. Research Limitations / Implications – This study showed the production planning process of one investigational product with the recruitment of few patients for the clinical trial. However, the number of patients enrolled can reach thousands in many clinical trials, and it does need a more complex production planning to avoid wastes and try to reduce the process costs. Practical Implications - This article provides a picture of the production planning of clinical trial supplies chain under uncertainty and the decisions that affect the large-scale production of commercial drugs and the pilot batch production of experimental drugs. Originality / value - Although the results of clinical trials is the most significant source of uncertainty in the development process of any new drug, a good clinical supply planning and processes management can avoid or attenuate the imminent risk of process failure.
Published: 2016
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23. STORAGE MANAGEMENT OF CLINICAL RESEARCH SUPPLIES OF A PHASE IIB/III, NATIONAL, MULTI-CENTRE, DOUBLE-BLIND AND RANDOMIZED STUDY

Author: Luiz Teruo Kawamoto Junior, Adriano Maniçoba da Silva, William de Paula Ferreira, Enio Fernandes Rodrigues, and Lila M. Harada
Subjects: Clinical Trial, Supply, Storage, Good practices, Production management. Operations management, TS155-194
Abstract: Abstract: New drugs suffer a long and slow proceeding to reach the market. On the one hand there are difficulties from the regulatory agency that delays the onset of clinical trial studies, on the other hand there is a slow patient recruitment during the course of the trial that prevents its completion. An efficient management of clinical trial supplies throughout the supply chain is essential. Thus, the objective of this study was to characterize the clinical supplies storage management in a national, multi-centre, double-blind and randomized study to evaluate the efficiency and safety of a combination of drugs to treat acute pain. The study was primarily focused on storage conditions of clinical supplies, detailing their distribution to the research sites. According to the data observed in this study, the clinical supplies storage management was not determinant for the slow patient recruitment process that reflected the delay to the end of the study. And although the centers were located in different states, there were no delays, loss or damage during storage and distribution that could compromise the proper stock and storage management of clinical trial supplies.
Published: 2016
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24. A Genetic Algorithm for Telecommunication Network Design.

Author: Silvana Livramento, Arnaldo V. Moura, Flavio Keidi Miyazawa, Mário M. Harada, and Rogério A. Miranda
Published: 2004
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25. Editors in Chief of Public Health Reports, 1878-2022: Men and Women Who Shaped the Discussion of Public Health Practice From 1918 Influenza to COVID-19

Author: Noelle M. Harada, Andrey Kuzmichev, and Hazel D. Dean
Subjects: Public Health, Environmental and Occupational Health
Abstract: Objectives: Public Health Reports ( PHR), the official journal of the Office of the US Surgeon General and US Public Health Service, is the oldest public health journal in the United States. Considering its heritage through the eyes of its past editors in chief (EICs), many of whom have been influential public health figures, can provide a fresh point of view on US public health history, of which the journal has been an integral part. Here, we reconstruct the timeline of past PHR EICs and identify women among them. Methods: We reconstructed the PHR EIC timeline by reviewing the journal’s previous mastheads and its articles describing leadership transitions. For each EIC, we identified dates in office, concurrent job titles, key contributions, and other important developments. Results: PHR had 25 EIC transitions in 109 years of its history, during which a single individual in charge of the journal could be identified. Only 5 identifiable EICs were women, who served as EIC for approximately one-quarter of the journal’s traceable history (28 of 109 years). PHR’s longest-serving EIC was a woman named Marian P. Tebben (1974-1994). Conclusions: PHR history revealed frequent EIC transitions and a low representation of women among its EICs. Mapping the timeline of past EICs of a historic public health journal can yield valuable insights into the workings of US public health, especially in the area of building a research evidence base.
Published: 2023

26. 892 A novel KITLG mutation detected only in the hyperpigmented epidermis of linear and whorled nevoid hypermelanosis and functional analysis of the mutant KITLG

Author: S. Yamaji, S. Shinkuma, A. Yuki, K. Hamada, M. Harada, R. Ommori, H. Matsuyama, R. Hayashi, H. Nguyen, R. Abe, and H. Asada
Subjects: Cell Biology, Dermatology, Molecular Biology, Biochemistry
Published: 2023

27. 858 Genotype-phenotype correlation of porokeratosis

Author: K. Hamada, S. Shinkuma, M. Harada, K. Ogawa, and H. Asada
Subjects: Cell Biology, Dermatology, Molecular Biology, Biochemistry
Published: 2023

28. WCN23-0232 RESERVED GAIT CAPACITY AND MORTALITY IN PATIENTS UNDERGOING HEMODIALYSIS

Author: S. YOSHIKOSHI, S. Yamamoto, Y. Suzuki, K. Imamura, M. Harada, N. Fukuzaki, A. Tobita, S. Nikkawa, and A. Matsunaga
Subjects: Nephrology
Published: 2023

29. Public Health Reports in 2021: Impact Factor Increase and New Article Collections on Racism and COVID-19

Author: Andrey Kuzmichev, Noelle M. Harada, Derek M. Griffith, Krista M. Powell, and Hazel D. Dean
Subjects: Special Article, Public Health, Environmental and Occupational Health
Published: 2022

30. First gadolinium loading to Super-Kamiokande

Author: K. Abe, C. Bronner, Y. Hayato, K. Hiraide, M. Ikeda, S. Imaizumi, J. Kameda, Y. Kanemura, Y. Kataoka, S. Miki, M. Miura, S. Moriyama, Y. Nagao, M. Nakahata, S. Nakayama, T. Okada, K. Okamoto, A. Orii, G. Pronost, H. Sekiya, M. Shiozawa, Y. Sonoda, Y. Suzuki, A. Takeda, Y. Takemoto, A. Takenaka, H. Tanaka, S. Watanabe, T. Yano, S. Han, T. Kajita, K. Okumura, T. Tashiro, J. Xia, G.D. Megias, D. Bravo-Berguño, L. Labarga, Ll. Marti, B. Zaldivar, B.W. Pointon, F.d.M. Blaszczyk, E. Kearns, J.L. Raaf, J.L. Stone, L. Wan, T. Wester, J. Bian, N.J. Griskevich, W.R. Kropp, S. Locke, S. Mine, M.B. Smy, H.W. Sobel, V. Takhistov, J. Hill, J.Y. Kim, I.T. Lim, R.G. Park, B. Bodur, K. Scholberg, C.W. Walter, L. Bernard, A. Coffani, O. Drapier, S. El Hedri, A. Giampaolo, M. Gonin, Th.A. Mueller, P. Paganini, B. Quilain, T. Ishizuka, T. Nakamura, J.S. Jang, J.G. Learned, L.H.V. Anthony, D. Martin, M. Scott, A.A. Sztuc, Y. Uchida, S. Cao, V. Berardi, M.G. Catanesi, E. Radicioni, N.F. Calabria, L.N. Machado, G. De Rosa, G. Collazuol, F. Iacob, M. Lamoureux, M. Mattiazzi, N. Ospina, L. Ludovici, Y. Maekawa, Y. Nishimura, M. Friend, T. Hasegawa, T. Ishida, T. Kobayashi, M. Jakkapu, T. Matsubara, T. Nakadaira, K. Nakamura, Y. Oyama, K. Sakashita, T. Sekiguchi, T. Tsukamoto, T. Boschi, J. Gao, F. Di Lodovico, J. Migenda, M. Taani, S. Zsoldos, Y. Kotsar, Y. Nakano, H. Ozaki, T. Shiozawa, A.T. Suzuki, Y. Takeuchi, S. Yamamoto, A. Ali, Y. Ashida, J. Feng, S. Hirota, T. Kikawa, M. Mori, T. Nakaya, R.A. Wendell, K. Yasutome, P. Fernandez, N. McCauley, P. Mehta, K.M. Tsui, Y. Fukuda, Y. Itow, H. Menjo, T. Niwa, K. Sato, M. Tsukada, J. Lagoda, S.M. Lakshmi, P. Mijakowski, J. Zalipska, J. Jiang, C.K. Jung, C. Vilela, M.J. Wilking, C. Yanagisawa, K. Hagiwara, M. Harada, T. Horai, H. Ishino, S. Ito, F. Kitagawa, Y. Koshio, W. Ma, N. Piplani, S. Sakai, G. Barr, D. Barrow, L. Cook, A. Goldsack, S. Samani, D. Wark, F. Nova, J.Y. Yang, S.J. Jenkins, M. Malek, J.M. McElwee, O. Stone, M.D. Thiesse, L.F. Thompson, H. Okazawa, S.B. Kim, J.W. Seo, I. Yu, A.K. Ichikawa, K. Nishijima, M. Koshiba, K. Iwamoto, Y. Nakajima, N. Ogawa, M. Yokoyama, K. Martens, M.R. Vagins, M. Kuze, S. Izumiyama, T. Yoshida, M. Inomoto, M. Ishitsuka, H. Ito, T. Kinoshita, R. Matsumoto, K. Ohta, M. Shinoki, T. Suganuma, J.F. Martin, H.A. Tanaka, T. Towstego, R. Akutsu, M. Hartz, A. Konaka, P. de Perio, N.W. Prouse, S. Chen, B.D. Xu, M. Posiadala-Zezula, D. Hadley, M. O’Flaherty, B. Richards, B. Jamieson, J. Walker, A. Minamino, G. Pintaudi, S. Sano, R. Sasaki, Abe, K., Bronner, C., Hayato, Y., Hiraide, K., Ikeda, M., Imaizumi, S., Kameda, J., Kanemura, Y., Kataoka, Y., Miki, S., Miura, M., Moriyama, S., Nagao, Y., Nakahata, M., Nakayama, S., Okada, T., Okamoto, K., Orii, A., Pronost, G., Sekiya, H., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Takenaka, A., Tanaka, H., Watanabe, S., Yano, T., Han, S., Kajita, T., Okumura, K., Tashiro, T., Xia, J., Megias, G. D., Bravo-Berguno, D., Labarga, L., Marti, L., Zaldivar, B., Pointon, B. W., Blaszczyk, F. D. M., Kearns, E., Raaf, J. L., Stone, J. L., Wan, L., Wester, T., Bian, J., Griskevich, N. J., Kropp, W. R., Locke, S., Mine, S., Smy, M. B., Sobel, H. W., Takhistov, V., Hill, J., Kim, J. Y., Lim, I. T., Park, R. G., Bodur, B., Scholberg, K., Walter, C. W., Bernard, L., Coffani, A., Drapier, O., Hedri, S. E., Giampaolo, A., Gonin, M., Mueller, T. A., Paganini, P., Quilain, B., Ishizuka, T., Nakamura, T., Jang, J. S., Learned, J. G., Anthony, L. H. V., Martin, D., Scott, M., Sztuc, A. A., Uchida, Y., Cao, S., Berardi, V., Catanesi, M. G., Radicioni, E., Calabria, N. F., Nascimento Machado, L., De Rosa, G., Collazuol, G., Iacob, F., Lamoureux, M., Mattiazzi, M., Ospina, N., Ludovici, L., Maekawa, Y., Nishimura, Y., Friend, M., Hasegawa, T., Ishida, T., Kobayashi, T., Jakkapu, M., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Boschi, T., Gao, J., Di Lodovico, F., Migenda, J., Taani, M., Zsoldos, S., Kotsar, Y., Nakano, Y., Ozaki, H., Shiozawa, T., Suzuki, A. T., Takeuchi, Y., Yamamoto, S., Ali, A., Ashida, Y., Feng, J., Hirota, S., Kikawa, T., Mori, M., Nakaya, T., Wendell, R. A., Yasutome, K., Fernandez, P., Mccauley, N., Mehta, P., Tsui, K. M., Fukuda, Y., Itow, Y., Menjo, H., Niwa, T., Sato, K., Tsukada, M., Lagoda, J., Lakshmi, S. M., Mijakowski, P., Zalipska, J., Jiang, J., Jung, C. K., Vilela, C., Wilking, M. J., Yanagisawa, C., Hagiwara, K., Harada, M., Horai, T., Ishino, H., Ito, S., Kitagawa, F., Koshio, Y., Ma, W., Piplani, N., Sakai, S., Barr, G., Barrow, D., Cook, L., Goldsack, A., Samani, S., Wark, D., Nova, F., Yang, J. Y., Jenkins, S. J., Malek, M., Mcelwee, J. M., Stone, O., Thiesse, M. D., Thompson, L. F., Okazawa, H., Kim, S. B., Seo, J. W., Yu, I., Ichikawa, A. K., Nishijima, K., Koshiba, M., Iwamoto, K., Nakajima, Y., Ogawa, N., Yokoyama, M., Martens, K., Vagins, M. R., Kuze, M., Izumiyama, S., Yoshida, T., Inomoto, M., Ishitsuka, M., Ito, H., Kinoshita, T., Matsumoto, R., Ohta, K., Shinoki, M., Suganuma, T., Martin, J. F., Tanaka, H. A., Towstego, T., Akutsu, R., Hartz, M., Konaka, A., de Perio, P., Prouse, N. W., Chen, S., Xu, B. D., Posiadala-Zezula, M., Hadley, D., O'Flaherty, M., Richards, B., Jamieson, B., Walker, J., Minamino, A., Pintaudi, G., Sano, S., and Sasaki, R.
Subjects: Nuclear and High Energy Physics, Gadolinium Neutrino Neutron Water Cherenkov detector, Physics - Instrumentation and Detectors, 010308 nuclear & particles physics, FOS: Physical sciences, Gadolinium, Neutron, Instrumentation and Detectors (physics.ins-det), 01 natural sciences, Water Cherenkov detector, 0103 physical sciences, Neutrino, 010306 general physics, Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation, Instrumentation and Methods for Astrophysics (astro-ph.IM)
Abstract: In order to improve Super-Kamiokande's neutron detection efficiency and to thereby increase its sensitivity to the diffuse supernova neutrino background flux, 13 tons of $\rm Gd_2(\rm SO_4)_3\cdot \rm 8H_2O$ (gadolinium sulfate octahydrate) was dissolved into the detector's otherwise ultrapure water from July 14 to August 17, 2020, marking the start of the SK-Gd phase of operations. During the loading, water was continuously recirculated at a rate of 60 m$^3$/h, extracting water from the top of the detector and mixing it with concentrated $\rm Gd_2(\rm SO_4)_3\cdot \rm 8H_2O$ solution to create a 0.02% solution of the Gd compound before injecting it into the bottom of the detector. A clear boundary between the Gd-loaded and pure water was maintained through the loading, enabling monitoring of the loading itself and the spatial uniformity of the Gd concentration over the 35 days it took to reach the top of the detector. During the subsequent commissioning the recirculation rate was increased to 120 m$^3$/h, resulting in a constant and uniform distribution of Gd throughout the detector and water transparency equivalent to that of previous pure-water operation periods. Using an Am-Be neutron calibration source the mean neutron capture time was measured to be $115\pm1$ $\mu$s, which corresponds to a Gd concentration of $111\pm2$ ppm, as expected for this level of Gd loading. This paper describes changes made to the water circulation system for this detector upgrade, the Gd loading procedure, detector commissioning, and the first neutron calibration measurements in SK-Gd., Comment: 37 pages, 19 Figures, Accepted for publication in Nucl. Instrum. Meth. A
Published: 2022

31. GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents

Author: Gina L. C. Yosten, Luigino Antonio Giancotti, Anthony H. Dickenson, Chun Guo, Willis K. Samson, Ryan Patel, Zhoumou Chen, Timothy M. Doyle, Caron M. Harada, Grant R. Kolar, Jinsong Zhang, Christopher J. Haddock, and Daniela Salvemini
Subjects: Male, 0301 basic medicine, MAPK/ERK pathway, Thalamus, Nerve Tissue Proteins, In situ hybridization, Ligands, CREB, PC12 Cells, Cell Line, Receptors, G-Protein-Coupled, Mice, 03 medical and health sciences, 0302 clinical medicine, Animals, Humans, Medicine, RNA, Small Interfering, biology, business.industry, Concise Communication, General Medicine, Nerve injury, Spinal cord, Sciatic Nerve, Rats, Up-Regulation, 030104 developmental biology, medicine.anatomical_structure, Spinal Cord, 030220 oncology & carcinogenesis, Neuropathic pain, biology.protein, Neuralgia, Female, medicine.symptom, Signal transduction, business, Neuroscience, Signal Transduction
Abstract: Treating neuropathic pain is challenging and novel non-opioid-based medicines are needed. Using unbiased receptomics, transcriptomic analyses, immunofluorescence, and in situ hybridization, we found that the expression of the orphan GPCR Gpr160 and GPR160 increased in the rodent dorsal horn of the spinal cord following traumatic nerve injury. Genetic and immunopharmacological approaches demonstrated that GPR160 inhibition in the spinal cord prevented and reversed neuropathic pain in male and female rodents without altering normal pain response. GPR160 inhibition in the spinal cord attenuated sensory processing in the thalamus, a key relay in the sensory discriminative pathways of pain. We also identified cocaine- and amphetamine-regulated transcript peptide (CARTp) as a GPR160 ligand. Inhibiting endogenous CARTp signaling in spinal cord attenuated neuropathic pain, whereas exogenous intrathecal CARTp evoked painful hypersensitivity through GPR160-dependent ERK and cAMP response element-binding protein (CREB). Our findings de-orphanize GPR160, identify it as a determinant of neuropathic pain and potential therapeutic target, and provide insights into its signaling pathways. CARTp is involved in many diseases including depression and reward and addiction; de-orphanization of GPR160 is a major step forward understanding the role of CARTp signaling in health and disease.
Published: 2020

32. Neutron tagging following atmospheric neutrino events in a water Cherenkov detector

Author: K. Abe, Y. Haga, Y. Hayato, K. Hiraide, K. Ieki, M. Ikeda, S. Imaizumi, K. Iyogi, J. Kameda, Y. Kanemura, Y. Kataoka, Y. Kato, Y. Kishimoto, S. Miki, S. Mine, M. Miura, T. Mochizuki, S. Moriyama, Y. Nagao, M. Nakahata, T. Nakajima, Y. Nakano, S. Nakayama, T. Okada, K. Okamoto, A. Orii, K. Sato, H. Sekiya, M. Shiozawa, Y. Sonoda, Y. Suzuki, A. Takeda, Y. Takemoto, A. Takenaka, H. Tanaka, S. Tasaka, T. Tomura, K. Ueno, S. Watanabe, T. Yano, T. Yokozawa, S. Han, T. Irvine, T. Kajita, I. Kametani, K. Kaneyuki, K.P. Lee, T. McLachlan, K. Okumura, E. Richard, T. Tashiro, R. Wang, J. Xia, G.D. Megias, D. Bravo-Berguño, L. Labarga, B. Zaldivar, M. Goldhaber, F.d.M. Blaszczyk, J. Gustafson, C. Kachulis, E. Kearns, J.L. Raaf, J.L. Stone, L.R. Sulak, S. Sussman, L. Wan, T. Wester, B.W. Pointon, J. Bian, G. Carminati, M. Elnimr, N.J. Griskevich, W.R. Kropp, S. Locke, A. Renshaw, M.B. Smy, H.W. Sobel, V. Takhistov, P. Weatherly, K.S. Ganezer, B.L. Hartfiel, J. Hill, W.E. Keig, N. Hong, J.Y. Kim, I.T. Lim, R.G. Park, T. Akiri, B. Bodur, A. Himmel, Z. Li, E. O'Sullivan, K. Scholberg, C.W. Walter, T. Wongjirad, L. Bernard, A. Coffani, O. Drapier, S. El Hedri, A. Giampaolo, J. Imber, Th.A. Mueller, P. Paganini, B. Quilain, T. Ishizuka, T. Nakamura, J.S. Jang, K. Choi, J.G. Learned, S. Matsuno, S.N. Smith, J. Amey, L.H.V. Anthony, R.P. Litchfield, W.Y. Ma, D. Marin, A.A. Sztuc, Y. Uchida, M.O. Wascko, V. Berardi, M.G. Catanesi, R.A. Intonti, E. Radicioni, N.F. Calabria, G. De Rosa, L.N. Machado, G. Collazuol, F. Iacob, M. Lamoureux, N. Ospina, L. Ludovici, M. Gonin, G. Pronost, Y. Maekawa, Y. Nishimura, S. Cao, M. Friend, T. Hasegawa, T. Ishida, T. Ishii, M. Jakkapu, T. Kobayashi, T. Matsubara, T. Nakadaira, K. Nakamura, Y. Oyama, K. Sakashita, T. Sekiguchi, T. Tsukamoto, T. Boschi, F. Di Lodovico, J. Migenda, S. Molina Sedgwick, M. Taani, S. Zsoldos, K.E. Abe, M. Hasegawa, Y. Isobe, Y. Kotsar, H. Miyabe, H. Ozaki, T. Shiozawa, T. Sugimoto, A.T. Suzuki, Y. Takeuchi, S. Yamamoto, A. Ali, Y. Ashida, C. Bronner, J. Feng, T. Hayashino, T. Hiraki, S. Hirota, K. Huang, M. Jiang, T. Kikawa, M. Mori, A. Murakami, KE. Nakamura, T. Nakaya, N.D. Patel, K. Suzuki, S. Takahashi, K. Tateishi, R.A. Wendell, K. Yasutome, P. Fernandez, N. McCauley, P. Mehta, A. Pritchard, K.M. Tsui, Y. Fukuda, Y. Itow, H. Menjo, G. Mitsuka, M. Murase, F. Muto, T. Niwa, T. Suzuki, M. Tsukada, K. Frankiewicz, P. Mijakowski, J. Hignight, J. Jiang, C.K. Jung, X. Li, J.L. Palomino, G. Santucci, C. Vilela, M.J. Wilking, C. Yanagisawa, D. Fukuda, K. Hagiwara, M. Harada, T. Horai, H. Ishino, S. Ito, T. Kayano, A. Kibayashi, H. Kitagawa, Y. Koshio, W. Ma, T. Mori, H. Nagata, N. Piplani, S. Sakai, M. Sakuda, Y. Takahira, C. Xu, R. Yamaguchi, Y. Kuno, G. Barr, D. Barrow, L. Cook, A. Goldsack, S. Samani, C. Simpson, D. Wark, F. Nova, R. Tacik, J.Y. Yang, A. Cole, S.J. Jenkins, M. Malek, J.M. McElwee, O. Stone, M.D. Thiesse, L.F. Thompson, H. Okazawa, Y. Choi, S.B. Kim, I. Yu, A.K. Ichikawa, K. Ito, K. Nishijima, R.G. Calland, P. de Perio, K. Martens, M. Murdoch, M.R. Vagins, M. Koshiba, Y. Totsuka, K. Iwamoto, Y. Nakajima, N. Ogawa, Y. Suda, M. Yokoyama, D. Hamabe, S. Izumiyama, M. Kuze, Y. Okajima, M. Tanaka, T. Yoshida, M. Inomoto, M. Ishitsuka, H. Ito, R. Matsumoto, K. Ohta, M. Shinoki, J.F. Martin, C.M. Nantais, H.A. Tanaka, T. Towstego, R. Akutsu, M. Hartz, A. Konaka, N.W. Prouse, S. Chen, B.D. Xu, Y. Zhang, S. Berkman, S. Tobayama, K. Connolly, R.J. Wilkes, M. Posiadala-Zezula, D. Hadley, B. Richards, B. Jamieson, J. Walker, Ll. Marti, A. Minamino, G. Pintaudi, S. Sano, R. Sasaki, Abe, K., Haga, Y., Hayato, Y., Hiraide, K., Ieki, K., Ikeda, M., Imaizumi, S., Iyogi, K., Kameda, J., Kanemura, Y., Kataoka, Y., Kato, Y., Kishimoto, Y., Miki, S., Mine, S., Miura, M., Mochizuki, T., Moriyama, S., Nagao, Y., Nakahata, M., Nakajima, T., Nakano, Y., Nakayama, S., Okada, T., Okamoto, K., Orii, A., Sato, K., Sekiya, H., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Takenaka, A., Tanaka, H., Tasaka, S., Tomura, T., Ueno, K., Watanabe, S., Yano, T., Yokozawa, T., Han, S., Irvine, T., Kajita, T., Kametani, I., Kaneyuki, K., Lee, K. P., Mclachlan, T., Okumura, K., Richard, E., Tashiro, T., Wang, R., Xia, J., Megias, G. D., Bravo-Bergu??o, D., Labarga, L., Zaldivar, B., Goldhaber, M., Blaszczyk, F. d. M., Gustafson, J., Kachulis, C., Kearns, E., Raaf, J. L., Stone, J. L., Sulak, L. R., Sussman, S., Wan, L., Wester, T., Pointon, B. W., Bian, J., Carminati, G., Elnimr, M., Griskevich, N. J., Kropp, W. R., Locke, S., Renshaw, A., Smy, M. B., Sobel, H. W., Takhistov, V., Weatherly, P., Ganezer, K. S., Hartfiel, B. L., Hill, J., Keig, W. E., Hong, N., Kim, J. Y., Lim, I. T., Park, R. G., Akiri, T., Bodur, B., Himmel, A., Li, Z., O'Sullivan, E., Scholberg, K., Walter, C. W., Wongjirad, T., Bernard, L., Coffani, A., Drapier, O., El Hedri, S., Giampaolo, A., Imber, J., Mueller, Th. A., Paganini, P., Quilain, B., Ishizuka, T., Nakamura, T., Jang, J. S., Choi, K., Learned, J. G., Matsuno, S., Smith, S. N., Amey, J., Anthony, L. H. V., Litchfield, R. P., Ma, W. Y., Marin, D., Sztuc, A. A., Uchida, Y., Wascko, M. O., Berardi, V., Catanesi, M. G., Intonti, R. A., Radicioni, E., Calabria, N. F., De Rosa, G., Nascimento Machado, L., Collazuol, G., Iacob, F., Lamoureux, M., Ospina, N., Ludovici, L., Gonin, M., Pronost, G., Maekawa, Y., Nishimura, Y., Cao, S., Friend, M., Hasegawa, T., Ishida, T., Ishii, T., Jakkapu, M., Kobayashi, T., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Boschi, T., Di Lodovico, F., Migenda, J., Molina Sedgwick, S., Taani, M., Zsoldos, S., Abe, K. E., Hasegawa, M., Isobe, Y., Kotsar, Y., Miyabe, H., Ozaki, H., Shiozawa, T., Sugimoto, T., Suzuki, A. T., Takeuchi, Y., Yamamoto, S., Ali, A., Ashida, Y., Bronner, C., Feng, J., Hayashino, T., Hiraki, T., Hirota, S., Huang, K., Jiang, M., Kikawa, T., Mori, M., Murakami, A., Nakamura, Ke., Nakaya, T., Patel, N. D., Suzuki, K., Takahashi, S., Tateishi, K., Wendell, R. A., Yasutome, K., Fernandez, P., Mccauley, N., Mehta, P., Pritchard, A., Tsui, K. M., Fukuda, Y., Itow, Y., Menjo, H., Mitsuka, G., Murase, M., Muto, F., Niwa, T., Suzuki, T., Tsukada, M., Frankiewicz, K., Mijakowski, P., Hignight, J., Jiang, J., Jung, C. K., Li, X., Palomino, J. L., Santucci, G., Vilela, C., Wilking, M. J., Yanagisawa, C., Fukuda, D., Hagiwara, K., Harada, M., Horai, T., Ishino, H., Ito, S., Kayano, T., Kibayashi, A., Kitagawa, H., Koshio, Y., Ma, W., Mori, T., Nagata, H., Piplani, N., Sakai, S., Sakuda, M., Takahira, Y., Xu, C., Yamaguchi, R., Kuno, Y., Barr, G., Barrow, D., Cook, L., Goldsack, A., Samani, S., Simpson, C., Wark, D., Nova, F., Tacik, R., Yang, J. Y., Cole, A., Jenkins, S. J., Malek, M., Mcelwee, J. M., Stone, O., Thiesse, M. D., Thompson, L. F., Okazawa, H., Choi, Y., Kim, S. B., Yu, I., Ichikawa, A. K., Ito, K., Nishijima, K., Calland, R. G., de Perio, P., Martens, K., Murdoch, M., Vagins, M. R., Koshiba, M., Totsuka, Y., Iwamoto, K., Nakajima, Y., Ogawa, N., Suda, Y., Yokoyama, M., Hamabe, D., Izumiyama, S., Kuze, M., Okajima, Y., Tanaka, M., Yoshida, T., Inomoto, M., Ishitsuka, M., Ito, H., Matsumoto, R., Ohta, K., Shinoki, M., Martin, J. F., Nantais, C. M., Tanaka, H. A., Towstego, T., Akutsu, R., Hartz, M., Konaka, A., Prouse, N. W., Chen, S., Xu, B. D., Zhang, Y., Berkman, S., Tobayama, S., Connolly, K., Wilkes, R. J., Posiadala-Zezula, M., Hadley, D., Richards, B., Jamieson, B., Walker, J., Marti, Ll., Minamino, A., Pintaudi, G., Sano, S., and Sasaki, R.
Subjects: Physics - Instrumentation and Detectors, Large detector systems for particle and astroparticle physics, hep-ex, Cherenkov detectors, FOS: Physical sciences, Acceleratorfysik och instrumentering, Instrumentation and Detectors (physics.ins-det), Accelerator Physics and Instrumentation, High Energy Physics - Experiment, Subatomär fysik, High Energy Physics - Experiment (hep-ex), Particle identification methods, Neutrino detectors, Subatomic Physics, Cherenkov detectors Large detector systems for particle and astroparticle physics Neutrino detectors Particle identification methods, Detectors and Experimental Techniques, Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation, Instrumentation and Methods for Astrophysics (astro-ph.IM), physics.ins-det, Mathematical Physics, Particle Physics - Experiment, astro-ph.IM
Abstract: We present the development of neutron-tagging techniques in Super-Kamiokande IV using a neural network analysis. The detection efficiency of neutron capture on hydrogen is estimated to be 26%, with a mis-tag rate of 0.016 per neutrino event. The uncertainty of the tagging efficiency is estimated to be 9.0%. Measurement of the tagging efficiency with data from an Americium-Beryllium calibration agrees with this value within 10%. The tagging procedure was performed on 3,244.4 days of SK-IV atmospheric neutrino data, identifying 18,091 neutrons in 26,473 neutrino events. The fitted neutron capture lifetime was measured as 218±9 μs. We present the development of neutron-tagging techniques in Super-Kamiokande IV using a neural network analysis. The detection efficiency of neutron capture on hydrogen is estimated to be 26%, with a mis-tag rate of 0.016 per neutrino event. The uncertainty of the tagging efficiency is estimated to be 9.0%. Measurement of the tagging efficiency with data from an Americium-Beryllium calibration agrees with this value within 10%. The tagging procedure was performed on 3,244.4 days of SK-IV atmospheric neutrino data, identifying 18,091 neutrons in 26,473 neutrino events. The fitted neutron capture lifetime was measured as 218 \pm 9 \mu s.
Published: 2022

33. 1O IMpower010: ctDNA status in patients (pts) with resected NSCLC who received adjuvant chemotherapy (chemo) followed by atezolizumab (atezo) or best supportive care (BSC)

Author: E. Felip, M. Srivastava, M. Reck, H. Wakelee, N.K. Altorki, E. Vallieres, R. Liersch, M. Harada, H. Tanaka, J.T. Hamm, S. McCune, E. Bennett, B.J. Gitlitz, V.A. McNally, S. Novello, M. Ballinger, W. Zou, B. Nabet, M. Das Thakur, and C. Zhou
Subjects: Oncology, Immunology and Allergy
Published: 2022

34. Role of Adenosine Kinase In Sphingosine-1-Phosphate Receptor 1-Induced Mechano-Hypersensitivities

Author: Timothy J. Garrett, Grant R. Kolar, Caron M. Harada, Daniela Salvemini, Filomena Lauro, Luigino Antonio Giancotti, and Taylor A Harmon
Subjects: Agonist, biology, medicine.drug_class, Chemistry, Sphingosine-1-phosphate receptor, Cell Biology, General Medicine, Adenosine kinase, Receptor antagonist, Adenosine, ADK, Cell biology, Cellular and Molecular Neuroscience, medicine, biology.protein, Signal transduction, S1PR1, medicine.drug
Abstract: Emerging evidence implicates the sphingosine-1-phosphate (S1P) receptor subtype 1 (S1PR1) in the development of neuropathic pain. Continued investigation of the signaling pathways downstream of S1PR1 are needed to support development of S1PR1 antagonists. In rodents, intrathecal (i.th.) injection of SEW2871, a selective S1PR1 agonist, activates the nod-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome, increases interleukin-1β (IL-1β) and causes behavioral hypersensitivity. I.th. injection of a IL-1β receptor antagonist blocks SEW2871-induced hypersensitivity, suggesting that IL-1β contributes to S1PR1’s actions. Interestingly, previous studies have suggested that IL-1β increases the expression/activity of adenosine kinase (ADK), a key regulator of adenosine signaling at its receptors (ARs). Increased ADK expression reduces adenosine signaling whereas inhibiting ADK restores the action of adenosine. Here, we show that SEW287-induced behavioral hypersensitivity is associated with increased expression of ADK in astrocytes of the dorsal horn of the spinal cord (DH-SC). Moreover, the ADK inhibitor, ABT702, blocks SEW2871-induced hypersensitivity. These findings link ADK activation to S1PR1. If SEW2871-induced pain is mediated by IL-1β, which in turn activates ADK and leads to mechano-allodynia, then blocking ADK should attenuate IL-1β effects. In support of this idea, recombinant rat (rrIL-1β)-induced allodynia was blocked by at least 90% with ABT702, functionally linking ADK to IL-1β. Moreover, the selective A3AR antagonist, MRS1523, prevents the ability of ABT702 to block SEW2871 and IL-1β-induced allodynia, implicating A3AR signaling in the beneficial effects exerted by ABT702. Our findings provide novel mechanistic insight into how S1PR1 signaling in the spinal cord produces hypersensitivity through IL1-b and ADK activation.
Published: 2021

35. Search for neutrinos in coincidence with gravitational wave events from the LIGO–Virgo O3a observing run with the Super-Kamiokande detector

Author: Y. Kanemura, A. Giampaolo, W. R. Kropp, Y. Hayato, A. A. Sztuc, P. Mehta, Pablo Fernandez, T. Hasegawa, F. Iacob, D. Bravo-Berguño, Y. Kuno, T. Towstego, O. Drapier, H. Ito, Sei-ichiro Watanabe, G.D. Barr, J. Bian, N. Piplani, S. Miki, S. V. Cao, M. R. Vagins, K. Martens, Y. Takemoto, L. F. Thompson, S. Imaizumi, A. Coffani, O. Stone, J. S. Jang, M. Taani, Seiko Hirota, T. Kikawa, M. Gonin, J. Xia, Masahiro Kuze, A. Goldsack, S. Han, M. J. Wilking, R. A. Wendell, M. B. Smy, Junjie Jiang, F. Nova, E. Radicioni, Kimihiro Okumura, B. Zaldivar, J. Y. Kim, S. Izumiyama, A. Orii, S. Mine, L. Cook, J. Migenda, John Hill, A. T. Suzuki, K. Okamoto, T. Horai, R. Sasaki, J. F. Martin, J. Kameda, B. Bodur, Yuichi Oyama, T. Nakadaira, J. McElwee, J. L. Stone, I. T. Lim, F. Di Lodovico, D. L. Wark, Vincenzo Berardi, Y. Maekawa, S. El Hedri, T. Sekiguchi, L. Ludovici, Th. A. Mueller, N. Ospina, K. Ohta, G. De Rosa, Hiromasa Tanaka, V. Takhistov, Hiroaki Menjo, C. Simpson, J. G. Learned, K. M. Tsui, P. Mijakowski, J. Y. Yang, K. Abe, J. L. Raaf, M. Tsukada, M. Thiesse, K. Iwamoto, H. K. Tanaka, Yasunari Suzuki, S. Samani, G. D. Megias, A. Konaka, M. G. Catanesi, N. J. Griskevich, Y. Nishimura, David Hadley, F. d. M. Blaszczyk, M. Inomoto, S. Locke, Masaki Ishitsuka, M. Jakkapu, Yusuke Koshio, S. Sakai, D. Barrow, M. Lamoureux, P. Weatherly, P. de Perio, T. Boschi, T. Niwa, K. Nakamura, T. Yoshida, A. Pritchard, C. K. Jung, R. Matsumoto, M. Hartz, T. Shiozawa, C. Vilela, Ahmed Ali, M. Koshiba, Masato Shiozawa, H. Ozaki, T. Tashiro, S. Moriyama, S. Nakayama, R. Akutsu, L. H. V. Anthony, Hussain Kitagawa, S. J. Jenkins, B. Jamieson, R. G. Park, Song Chen, P. Paganini, M. Miura, Masayuki Nakahata, H. W. Sobel, Yuuki Nakano, Y. Uchida, B. D. Xu, Ll. Marti, Kate Scholberg, K. Hagiwara, Yutaka Nakajima, B. W. Pointon, D. Martin, Manabu Tanaka, K. Sato, G. Pintaudi, H. Okazawa, M. Ikeda, L. Wan, S. Molina Sedgwick, Hirokazu Ishino, Y. Kotsar, N. F. Calabria, Yuto Ashida, C. Yanagisawa, E. Kearns, C. Bronner, Masashi Yokoyama, Intae Yu, K. Yasutome, T. Nakamura, G. Collazuol, J. Walker, L. N. Machado, N. Ogawa, K. Nishijima, T. Wester, L. Bernard, T. Ishizuka, M. Harada, Tsuyoshi Nakaya, Y. Nagao, Atsushi Takeda, A. Minamino, Rongkun Wang, S. B. Kim, M. Shinoki, A. K. Ichikawa, N. McCauley, L. Labarga, T. Kobayashi, M. Malek, N. W. Prouse, B. Richards, T. Matsubara, S. Yamamoto, C. W. Walter, K. Sakashita, J. Feng, M. Posiadala-Zezula, W. Ma, B. Quilain, Hiroyuki Sekiya, Y. Kataoka, Y. Fukuda, Y. Takeuchi, T. Kajita, Takatomi Yano, M. Friend, M. Mori, Y. Sonoda, S. Sano, Yoshitaka Itow, G. Pronost, Shintaro Ito, S. Zsoldos, T. Tsukamoto, T. Okada, T. Ishida, A. Takenaka, UAM. Departamento de Física Teórica, Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Super-Kamiokande, Abe, K., Bronner, C., Hayato, Y., Ikeda, M., Imaizumi, S., Kameda, J., Kanemura, Y., Kataoka, Y., Miki, S., Miura, M., Moriyama, S., Nagao, Y., Nakahata, M., Nakayama, S., Okada, T., Okamoto, K., Orii, A., Pronost, G., Sekiya, H., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Takenaka, A., Tanaka, H., Watanabe, S., Yano, T., Han, S., Kajita, T., Okumura, K., Tashiro, T., Wang, R., Xia, J., Megias, G. D., Bravo-Berguno, D., Labarga, L., Marti, Ll., Zaldivar, B., Pointon, B. W., Blaszczyk, F. D. M., Kearns, E., Raaf, J. L., Stone, J. L., Wan, L., Wester, T., Bian, J., Griskevich, N. J., Kropp, W. R., Locke, S., Mine, S., Smy, M. B., Sobel, H. W., Takhistov, V., Weatherly, P., Hill, J., Kim, J. Y., Lim, I. T., Park, R. G., Bodur, B., Scholberg, K., Walter, C. W., Bernard, L., Coffani, A., Drapier, O., El Hedri, S., Giampaolo, A., Gonin, M., Mueller, Th. A., Paganini, P., Quilain, B., Ishizuka, T., Nakamura, T., Jang, J. S., Learned, J. G., Anthony, L. H. V., Martin, D. G. R., Sztuc, A. A., Uchida, Y., Berardi, V., Catanesi, M. G., Radicioni, E., Calabria, N. F., Nascimento Machado, L., de Rosa, G., Collazuol, G., Iacob, F., Lamoureux, M., Ospina, N., Ludovici, L., Maekawa, Y., Nishimura, Y., Cao, S., Friend, M., Hasegawa, T., Ishida, T., Jakkapu, M., Kobayashi, T., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Kotsar, Y., Nakano, Y., Ozaki, H., Shiozawa, T., Suzuki, A. T., Takeuchi, Y., Yamamoto, S., Ali, A., Ashida, Y., Feng, J., Hirota, S., Kikawa, T., Mori, M., Nakaya, T., Wendell, R. A., Yasutome, K., Fernandez, P., Mccauley, N., Mehta, P., Pritchard, A., Tsui, K. M., Fukuda, Y., Itow, Y., Menjo, H., Niwa, T., Sato, K., Tsukada, M., Mijakowski, P., Jiang, J., Jung, C. K., Vilela, C., Wilking, M. J., Yanagisawa, C., Hagiwara, K., Harada, M., Horai, T., Ishino, H., Ito, S., Koshio, Y., Kitagawa, H., Ma, W., Piplani, N., Sakai, S., Kuno, Y., Barr, G., Barrow, D., Cook, L., Goldsack, A., Samani, S., Simpson, C., Wark, D., Nova, F., Boschi, T., Di Lodovico, F., Migenda, J., Molina Sedgwick, S., Taani, M., Zsoldos, S., Yang, J. Y., Jenkins, S. J., Malek, M., Mcelwee, J. M., Stone, O., Thiesse, M. D., Thompson, L. F., Okazawa, H., Kim, S. B., Yu, I., Nishijima, K., Koshiba, M., Iwamoto, K., Nakajima, Y., Ogawa, N., Yokoyama, M., Martens, K., Vagins, M. R., Izumiyama, S., Kuze, M., Tanaka, M., Yoshida, T., Inomoto, M., Ishitsuka, M., Ito, H., Matsumoto, R., Ohta, K., Shinoki, M., Martin, J. F., Tanaka, H. A., Towstego, T., Akutsu, R., Hartz, M., Konaka, A., de Perio, P., Prouse, N. W., Chen, S., Xu, B. D., Posiadala-Zezula, M., Hadley, D., Richards, B., Jamieson, B., Walker, J., Minamino, A., Pintaudi, G., Sano, S., Sasaki, R., and Ichikawa, A. K.
Subjects: Astrophysics, KAMIOKANDE, Neutrino Astronomy, GeV, 01 natural sciences, 7. Clean energy, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), Neutrino astronomy Gravitational wave astronomy High energy astrophysics Black holes Compact objects Neutron stars Transient sources, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], LIGO, 010303 astronomy & astrophysics, QC, QB, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), energy: emission, Black holes, Neutrino, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics, High energy astrophysics, High-energy astronomy, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Gravitational-wave astronomy, Neutron stars, neutrino: spectrum, 0103 physical sciences, Instrumentation and Methods for Astrophysics (astro-ph.IM), Compact objects, flavor, 010308 nuclear & particles physics, Gravitational wave, background, gravitational radiation, Física, Astronomy and Astrophysics, trigger, Transient sources, flux, Neutron star, VIRGO, Space and Planetary Science, High Energy Physics::Experiment, Gravitational wave astronomy, Neutrino astronomy, Super-Kamiokande, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], statistical
Abstract: The Super-Kamiokande detector can be used to search for neutrinos in time coincidence with gravitational waves detected by the LIGO-Virgo Collaboration (LVC). Both low-energy ($7-100$ MeV) and high-energy ($0.1-10^5$ GeV) samples were analyzed in order to cover a very wide neutrino spectrum. Follow-ups of 36 (out of 39) gravitational waves reported in the GWTC-2 catalog were examined; no significant excess above the background was observed, with 10 (24) observed neutrinos compared with 4.8 (25.0) expected events in the high-energy (low-energy) samples. A statistical approach was used to compute the significance of potential coincidences. For each observation, p-values were estimated using neutrino direction and LVC sky map ; the most significant event (GW190602_175927) is associated with a post-trial p-value of $7.8\%$ ($1.4\sigma$). Additionally, flux limits were computed independently for each sample and by combining the samples. The energy emitted as neutrinos by the identified gravitational wave sources was constrained, both for given flavors and for all-flavors assuming equipartition between the different flavors, independently for each trigger and by combining sources of the same nature., Comment: 16 pages, 5 figures. v2: adding corrections from The Astrophysical Journal review
Published: 2021

36. 85P Safety and efficacy of atezolizumab (Atezo) + bevacizumab (Bev) in Japanese patients (pts) with unresectable hepatocellular carcinoma (uHCC): A prospective, multicenter, observational study (ELIXIR) - A preliminary analysis

Author: M. Ikeda, N. Kato, T. Kagawa, T. Yamashita, M. Moriguchi, S. Nakamura, K. Sawada, H. Iijima, T. Kamoshida, K. Nakao, K. Ohkawa, R. Sugimoto, T. Takehara, M. Harada, Y. Yamamoto, T. Ito, M. Kudo, N. Kokudo, K. Yamamoto, and J. Furuse
Subjects: Oncology, Hematology
Published: 2022

37. A Planning Method Of Collision Free Path For A Manipulator.

Author: M. Harada, M. Kunimitsu, and M. Yamada
Published: 1992
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38. Novel Non-Opioid Based Therapeutics for Chronic Neuropathic Pain

Author: Timothy M, Doyle, Kathryn, Braden, Caron M, Harada, Fatma, Mufti, Rachel M, Schafer, and Daniela, Salvemini
Subjects: Analgesics, Opioid, Science of Medicine | Feature Series, Humans, Neuralgia, Chronic Pain
Abstract: Chronic neuropathic pain is currently a major health issue in U.S. complicated by the lack of non-opioid analgesic alternatives. Our investigations led to the discovery of major signaling pathways involved in the transition of acute to chronic neuropathic pain and the identification of several targets for therapeutic intervention. Our translational approach has facilitated the advancement of novel medicines for chronic neuropathic pain that are in advanced clinical development and clinical trials.
Published: 2021

39. Diffuse Supernova Neutrino Background search at Super-Kamiokande with neutron tagging

Author: K. Sakashita, A. T. Suzuki, K. Okamoto, M. Posiadala-Zezula, T. Nakadaira, Takuto Suganuma, David Wark, Y. Kataoka, Y. Takeuchi, S. Sakai, Y. Nishimura, Shintaro Ito, Atsushi Takeda, G.D. Barr, B. Quilain, E. Kearns, T. Yano, Tatsuya Kikawa, L. Marti, Yasuhiro Nakajima, Masashi Yokoyama, Tatsushi Kinoshita, Joanna Zalipska, Y. Nagao, A. Minamino, Henry W. Sobel, Marco Mattiazzi, J. McElwee, J. Y. Kim, M. Shinoki, Kenzo Nakamura, M. Friend, N. W. Prouse, Yoshihiro Suzuki, H. A. Tanaka, C. W. Walter, A. Coffani, T. Ishizuka, N. McCauley, Tsuyoshi Nakaya, O. Stone, M. Malek, S. Miki, Takashi Kobayashi, David Hadley, T. Hasegawa, C. K. Jung, S. Yamamoto, Makoto Miura, Yuichi Oyama, O. Drapier, M. Ikeda, Masato Shiozawa, L. Ludovici, A. Takenaka, Hiroyuki Sekiya, S. Izumiyama, T. Matsubara, N. Piplani, Soo-Bong Kim, J. Y. Yang, Y. Fukuda, L. Wan, A. Ali, J. Feng, T. Tsukamoto, S. Locke, S. Mohan Lakshmi, A. Konaka, Hiroaki Menjo, M. Koshiba, Masahiro Kuze, F. Nova, M. Hartz, Takaaki Kajita, R. G. Park, Yuuki Nakano, Yusuke Koshio, R. Sasaki, D. Barrow, Thomas A. Mueller, T. Ishida, B. W. Pointon, Natalv Ospina, Kate Scholberg, K. Yasutome, John Fraser Martin, James Hill, T. Tashiro, Hirokazu Ishino, S. J. Jenkins, E. Radicioni, Marcus O'Flaherty, T. Nakamura, R. Matsumoto, G. Collazuol, Intae Yu, Mark Scott, N. Ogawa, J. L. Raaf, C. Yanagisawa, Yoshinari Hayato, L. Bernard, K. Martens, M. Jakkapu, S. Mine, K. M. Tsui, A. Goldsack, S. Nakayama, M. Taani, T. Boschi, R. A. Wendell, M. Mori, M. Lamoureux, Y. Sonoda, Hiroshi Ito, S. Sano, K. Nishijima, Yoshitaka Itow, T. Wester, S. Han, G. Pronost, H. Okazawa, M. J. Wilking, D. Martin, K. Sato, A. K. Ichikawa, J. Kameda, F. Iacob, P. Mijakowski, K. Abe, Shuhei Watanabe, B. Bodur, Y. Kanemura, A. Giampaolo, Pablo Fernandez, P. Mehta, T. Towstego, S. Zsoldos, Vincenzo Berardi, S. Cao, William R. Kropp, T. Sekiguchi, S. Chen, G. D. Megias, J. Bian, M. Gonin, J. Xia, Sonia El Hedri, M. Thiesse, K. Iwamoto, C. Bronner, Gianfranca De Rosa, J. S. Jang, H. Ozaki, Hussain Kitagawa, B. Jamieson, Patrick de Perio, Katsuki Hiraide, K. Nakamura, Y. Maekawa, Jeff N. Griskevich, S. Moriyama, G. Pintaudi, Masayuki Nakahata, Y. Uchida, N. F. Calabria, J. G. Learned, H. K. Tanaka, P. Paganini, B. D. Xu, S. Samani, M. G. Catanesi, Lester D.R. Thompson, M. R. Vagins, Y. Kotsar, John Walker, L. Cook, I. T. Lim, L. H. V. Anthony, R. Akutsu, C. Vilela, FD Lodovico, Junjie Jiang, V. Takhistov, Justyna Lagoda, Jingyuan Gao, W. Ma, L. Labarga, B. Richards, Kimihiro Okumura, Yasuhiro Takemoto, Masaki Ishitsuka, M. Inomoto, A. A. Sztuc, M. B. Smy, B. Zaldivar, J. Migenda, L. N. Machado, and M. Harada
Subjects: Physics, Supernova, Neutron, Astrophysics, Neutrino, Super-Kamiokande
Published: 2021

40. Low energy radioactivity BG model in Super-Kamiokande detector from SK-IV data

Author: S. J. Jenkins, K. Nakamura, M. R. Vagins, M. Taani, J. L. Raaf, John Walker, H. Okazawa, Masaki Ishitsuka, S. Moriyama, A. A. Sztuc, P. Mehta, S. Miki, Masayuki Nakahata, Y. Uchida, I. T. Lim, L. H. V. Anthony, Junjie Jiang, V. Takhistov, Yoshinari Hayato, T. Towstego, M. Jakkapu, J. Y. Kim, Y. Maekawa, Patrick de Perio, Atsushi Takeda, T. Boschi, Yasuhiro Nakajima, J. G. Learned, Shuhei Watanabe, A. K. Ichikawa, T. Yano, Hiroshi Ito, A. T. Suzuki, K. Okamoto, Vincenzo Berardi, J. Kameda, S. Izumiyama, Joanna Zalipska, H. K. Tanaka, L. Cook, A. Coffani, S. Samani, M. G. Catanesi, O. Drapier, M. B. Smy, B. Zaldivar, Y. Takeuchi, J. Migenda, O. Stone, B. Bodur, T. Nakadaira, Takashi Kobayashi, P. Mijakowski, S. Zsoldos, Sonia El Hedri, T. Hasegawa, A. Ali, Katsuki Hiraide, Makoto Miura, K. Nishijima, M. Thiesse, K. Iwamoto, Justyna Lagoda, T. Wester, F. Iacob, Jingyuan Gao, Y. Nagao, A. Minamino, S. Mohan Lakshmi, Lester D.R. Thompson, M. Hartz, L. N. Machado, Kenzo Nakamura, K. Sakashita, W. Ma, T. Matsubara, William R. Kropp, T. Sekiguchi, S. Chen, M. Shinoki, M. Harada, N. McCauley, S. Sakai, M. Posiadala-Zezula, R. Akutsu, Marco Mattiazzi, J. Feng, M. Friend, Yuuki Nakano, K. Abe, Shintaro Ito, M. Malek, N. Piplani, B. W. Pointon, S. Yamamoto, Y. Kanemura, A. Giampaolo, Kate Scholberg, Hiroaki Menjo, N. W. Prouse, C. W. Walter, E. Kearns, David Wark, P. Paganini, Kimihiro Okumura, Takaaki Kajita, C. Vilela, T. Tashiro, FD Lodovico, M. Koshiba, B. D. Xu, Masashi Yokoyama, G.D. Barr, Yasuhiro Takemoto, T. Nakamura, S. Locke, Y. Kataoka, James Hill, M. Inomoto, Intae Yu, R. G. Park, Tatsuya Kikawa, G. D. Megias, Pablo Fernandez, R. Matsumoto, L. Marti, N. Ogawa, G. Pintaudi, David Hadley, Hiroyuki Sekiya, J. S. Jang, Hirokazu Ishino, N. Jeff Griskevich, L. Labarga, Soo-Bong Kim, S. Han, L. Bernard, T. Ishizuka, C. Yanagisawa, Tsuyoshi Nakaya, Y. Fukuda, L. Wan, B. Richards, T. Tsukamoto, K. Yasutome, Marcus O'Flaherty, C. K. Jung, Yuichi Oyama, M. Ikeda, A. Goldsack, N. F. Calabria, S. Nakayama, G. Collazuol, Mark Scott, Masato Shiozawa, R. A. Wendell, L. Ludovici, J. Y. Yang, T. Ishida, K. Martens, S. Mine, K. M. Tsui, Y. Kotsar, Y. Nishimura, Masahiro Kuze, F. Nova, R. Sasaki, A. Konaka, M. Lamoureux, Yusuke Koshio, D. Martin, J. Bian, H. Ozaki, Hussain Kitagawa, B. Jamieson, Natalv Ospina, S. Cao, D. Barrow, John Fraser Martin, A. Takenaka, K. Sato, C. Bronner, M. Gonin, J. Xia, Gianfranca De Rosa, Tatsushi Kinoshita, Yoshihiro Suzuki, Henry W. Sobel, J. McElwee, H. A. Tanaka, E. Radicioni, B. Quilain, M. Mori, Y. Sonoda, S. Sano, Yoshitaka Itow, Takuto Suganuma, G. Pronost, M. J. Wilking, Thomas A. Mueller, Pronost, Guillaume, Abe, Ko, Bronner, Christophe, Hayato, Yoshinari, Hiraide, Katsuki, Ikeda, Motoyasu, Kameda, Jun, Kanemura, Yuki, Kataoka, Yousuku, Miki, Shintaro, Miura, Makoto, Moriyama, Shigetaka, Nagao, Yoshiki, Nakahata, Masayuki, Nakayama, Shoei, Okamoto, Kohei, Sekiya, Hiroyuki, Shiozawa, Masato, Sonoda, Yutaro, Suzuki, Yoichiro, Takeda, Atsushi, Takemoto, Yasuhiro, Takenaka, Akira, Tanaka, Hidekazu, Watanabe, Shuhei, Yano, Takatomi, Han, Seungho, Kajita, Takaaki, Okumura, Kimihiro, Tashiro, Takuya, Xia, Junjie, Megias, Guillermo, Labarga, Lui, Marti, Llui, Zaldivar, Bryan, Pointon, Barry W., Kearns, Edward, Raaf, Jennifer L., Wan, Linyan, Wester, Thoma, Bian, Jianming, Griskevich, N. Jeff, Kropp, William R., Locke, Scott, Mine, Shunichi, Smy, Michael, Sobel, Henry W., Takhistov, Volodymyr, Hill, Jame, Kim, Jae Yool, Lim, In Taek, Park, Ryeong Gyoon, Bodur, Baran, Scholberg, Kate, Walter, Chri, Bernard, Laura, Coffani, Alice, Drapier, Olivier, El Hedri, Sonia, Giampaolo, Alberto, Gonin, Michel, Mueller, Thomas A., Paganini, Pascal, Quilain, Benjamin, Ishizuka, Takeharu, Nakamura, Taku, Jang, Jae Seung, Learned, John G., Cao, Son, Anthony, Lauren H. V., Martin, Daniel, Scott, Mark, Sztuc, Artur A., Uchida, Yoshi, Berardi, Vincenzo, Catanesi, Maria Gabriella, Radicioni, Emilio, Calabria, Nicola F., Machado, Lucas N., De Rosa, Gianfranca, Collazuol, Gianmaria, Iacob, Fabio, Lamoureux, Mathieu, Mattiazzi, Marco, Ospina, Natalv, Ludovici, Lucio, Maekawa, Yuto, Nishimura, Yasuhiro, Friend, Megan, Hasegawa, Takuya, Ishida, Taku, Kobayashi, Takashi, Jakkapu, Mahesh, Matsubara, Tsunayuki, Nakadaira, Takeshi, Nakamura, Kenzo, Oyama, Yuichi, Sakashita, Ken, Sekiguchi, Tetsuro, Tsukamoto, Toshifumi, Boschi, Tommaso, Di Lodovico, Francesca, Gao, Jingyuan, Migenda, Jost, Taani, Mahdi, Zsoldos, Stephane, Nakano, Yuuki, Ozaki, Hironori, Suzuki, Atsumu, Takeuchi, Yasuo, Yamamoto, Shotaro, Kotsar, Yurii, Ali, Ajmi, Feng, Jiahui, Kikawa, Tatsuya, Mori, Masamitsu, Nakaya, Tsuyoshi, Wendell, Roger, Yasutome, Kenji, Fernández, Pablo, Mccauley, Neil, Mehta, Pruthvi, Tsui, Ka Ming, Fukuda, Yoshiyuki, Itow, Yoshitaka, Menjo, Hiroaki, Sato, Kazufumi, Lagoda, Justyna, Lakshmi, S. Mohan, Mijakowski, Piotr, Zalipska, Joanna, Jiang, Junjie, Jung, Chang K., Vilela, Cristovao, Wilking, Michael, Yanagisawa, Chiaki, Harada, Masayuki, Ishino, Hirokazu, Ito, Shintaro, Kitagawa, Hussain, Koshio, Yusuke, Ma, Wenjie, Piplani, Nishtha, Sakai, Seiya, Barr, Gile, Barrow, Danial, Cook, Laurence, Goldsack, Alexander, Samani, Soniya, Wark, David, Nova, Federico, Yang, Jeong Yeol, Jenkins, Sam J., Malek, Matthew, Mcelwee, Jordan, Stone, Owen, Thiesse, Matthew D., Thompson, Lee F., Okazawa, Hiroko, Kim, Soo Bong, Yu, Intae, Ichikawa, Atsuko, Nakamura, Kiseki, Nishijima, Kyoshi, Koshiba, Masatoshi, Iwamoto, Konosuke, Nakajima, Yasuhiro, Ogawa, Natsumi, Yokoyama, Masashi, Martens, Kai, Vagins, Mark, Kuze, Masahiro, Izumiyama, Shota, Inomoto, Michitaka, Ishitsuka, Masaki, Ito, Hiroshi, Kinoshita, Tatsushi, Matsumoto, Ryo, Shinoki, Masataka, Suganuma, Takuto, Martin, John Fraser, Tanaka, Hirohisa, Towstego, Trevor, Akutsu, Ryosuke, de Perio, Patrick, Hartz, Mark, Konaka, Akira, Prouse, Nick, Chen, Shaomin, Xu, Benda D., Posiadala-Zezula, Magdalena, Hadley, David, O'Flaherty, Marcu, Richards, Benjamin, Jamieson, Blair, Walker, John, Minamino, Akihiro, Pintaudi, Ggiorgio, Sano, Shiochi, and Sasaki, Ryota
Subjects: Physics, Physics::Instrumentation and Detectors, Solar neutrino, Physics::Medical Physics, Detector, Water source, chemistry.chemical_element, Radon, Nuclear physics, Low energy, chemistry, High Energy Physics::Experiment, Neutrino, Super-Kamiokande, Solar data
Abstract: The radioactivity background are among the most dangerous background for low energy neutrino analysis in Super-Kamiokande (SK), like the solar neutrino analysis. Among them, the main contribution is coming from $^{222}$Rn, which is spread in the detector's water due to the water source and to the photo multiplier (PMT) emanations. Up to now, its exact distribution in the detector was not known. Using our knowledge of the radon concentration in the detector water, and the SK-IV solar data, we developed a model of the radon distribution in the detector. The uncertainty on the Rn concentration associated with this model was estimated to be $\sim0.1$ mBq/m$^{3}$
Published: 2021

41. P–632 Examination of temporal changes in phenotype and gut microbiome during the process of growth in polycystic ovary syndrome (PCOS) model induced by prenatal androgen exposure

Author: A Kusamoto, M Harada, J M Azhary, C Kunitomi, E Nose, H Koike, Z Xu, Y Urata, T Takahashi, and Y Osuga
Subjects: medicine.medical_specialty, medicine.drug_class, business.industry, Polycystic ovary syndrome (PCOS), Rehabilitation, Obstetrics and Gynecology, Androgen, medicine.disease, Phenotype, Gut microbiome, Endocrinology, Reproductive Medicine, Internal medicine, medicine, business
Abstract: Study question From when do abnormality in gut microbiome and phenotypes of PCOS appear during the process of growth? Summary answer Reproductive phenotypes of PCOS appear from 6 weeks and metabolic phenotypes from 12 weeks onward. Alteration in gut microbiome appears as early as 4 weeks. What is known already The etiology of PCOS remains largely unknown, however PCOS is considered as a complex multigenic disorder with strong epigenetic and environmental influence. Previous studies have suggested that fetal over-exposure to androgens could be the main factor of the development of PCOS after birth. On the other hands, recent studies on both human and PCOS rodent models have demonstrated the association between PCOS and alteration of gut microbiome in adulthood. Furthermore, it was recently reported that gut microbiome in obese adolescent with PCOS is different from obese adolescent without PCOS. Study design, size, duration A rodent PCOS model induced by prenatal dehydroepiandrosterone (DHT) exposure was applied to this study. Phenotypes and gut microbiome were compared between PCOS model mice (n = 12/group) and control mice (n = 10/group) at each stage of growth; 4 weeks (prepuberty), 6 weeks (puberty), 8 weeks (adolescent), 12 weeks (young adult), and 16 weeks (adult). The determinants for PCOS phenotypes are onset of puberty, estrous cycle, morphology of ovaries, serum testosterone level, body weight, and insulin resistance. Participants/materials, setting, methods Pregnant dams were subcutaneously injected on days of 16, 17, and 18 of gestation with either sesame oil for control groups or sesame oil containing 250µg of DHT for prenatal DHT groups. The evaluation of PCOS phenotypes and gut microbiome in female offspring were performed at each stage of growth. For examination of gut microbiota, next generation sequencing and bioinformatics analysis of 16S rRNA genes were performed on DNA extracted from mouse fecal samples. Main results and the role of chance Prenatal DHT mice exhibited delayed puberty onset, disrupted estrous cycle, and significantly increased testosterone levels from 6 weeks onward. Significantly increased atretic antral follicles were observed in prenatal DHT mice at 6, 12, and 16 weeks. Prenatal DHT mice showed significantly decreased body weight at 4, 6, 8 weeks and increased body weight from 12 weeks onward. As for gut microbiome, alpha-diversity was significantly different between control and prenatal DHT mice from 8 weeks onward and beta-diversity was significantly different at 6 and 8 weeks. Altered composition of gut microbiota was observed as early as 4 weeks. At phylum level, Firmicutes are significantly increased in prenatal DHT mice at 4 and 8 weeks and decreased at 16 weeks. Actinobacteria phylum showed significant decrease at 6 and 8 weeks in prenatal DHT mice. At genus level, relative abundance of several bacterial taxa significantly differed between control and prenatal DHT mice; some taxa, such as Allobaculum, Adlercreutzia, Bilophila, Clostridium, Gemella, Gemmiger, Roseburia, Ruminococcus, Staphylococcus, and Sutterella, exhibited constant increase or decrease in prenatal DHT mice during the process of growth. Interestingly, Roseburia was never detected in prenatal DHT mice, while approximately half of control mice harbored Roseburia at 12 and 16 weeks. Limitations, reasons for caution It is not clearly determined whether alteration in gut microbiome is cause or result of PCOS development, although the changes in gut microbiome seemed to precede the appearance of typical PCOS phenotypes in the present study. Mouse model does not completely recapitulate human PCOS. Wider implications of the findings: Our findings suggest that prenatal androgen exposure causes alteration of gut microbiome from pre-puberty onward, even before PCOS phenotypes become apparent. Intervention for girls at risk of PCOS with pre/pro-biotics may prevent them from developing PCOS in future. Trial registration number Not applicable
Published: 2021

42. Ovotesticular disorders of sex development in FGF9 mouse models of human synostosis syndromes

Author: AD, Bird, primary, BM, Croft, additional, M, Harada, additional, L, Tang, additional, L, Zhao, additional, Z, Ming, additional, S, Bagheri-Fam, additional, P, Koopman, additional, Z, Wang, additional, K, Akita, additional, and VR, Harley, additional
Published: 2021
Full Text: View/download PDF

43. Clinical significance of low-density lipoprotein-triglycerides in patients with familial hypercholesterolemia

Author: M. Ogura, Y. Ito, and M. Harada-Shiba
Subjects: Cardiology and Cardiovascular Medicine
Published: 2022

44. Past, Present and Future of Cocaine- and Amphetamine-Regulated Transcript Peptide

Author: Gislaine Almeida-Pereira, Caron M. Harada, Gina L. C. Yosten, Lauren M. Stein, Willis K. Samson, Matthew R. Hayes, Daniela Salvemini, Grant R. Kolar, and Christopher J. Haddock
Subjects: Cart, Neuropeptide, Experimental and Cognitive Psychology, Peptide, Nerve Tissue Proteins, Biology, Cocaine and amphetamine regulated transcript, Article, 03 medical and health sciences, Behavioral Neuroscience, 0302 clinical medicine, Cocaine, Reward, immune system diseases, mental disorders, medicine, 0501 psychology and cognitive sciences, 050102 behavioral science & comparative psychology, Receptor, Gene, G protein-coupled receptor, chemistry.chemical_classification, 05 social sciences, Neuropeptides, virus diseases, Feeding Behavior, medicine.disease, chemistry, nervous system, Neuroscience, 030217 neurology & neurosurgery, Ingestive behaviors, hormones, hormone substitutes, and hormone antagonists
Abstract: The existence of the peptide encoded by the cocaine- and amphetamine-regulated transcript (Cartpt) has been recognized since 1981, but it was not until 1995, that the gene encoding CART peptide (CART) was identified. With the availability of the predicted protein sequence of CART investigators were able to identify sites of peptide localization, which then led to numerous approaches attempting to clarify CART's multiple pharmacologic effects and even provide evidence of potential physiologic relevance. Although not without controversy, a picture emerged of the importance of CART in ingestive behaviors, reward behaviors and even pain sensation. Despite the wealth of data hinting at the significance of CART, in the absence of an identified receptor, the full potential for this peptide or its analogs to be developed into therapeutic agents remained unrealized. There was evidence favoring the action of CART via a G protein-coupled receptor (GPCR), but despite multiple attempts the identity of that receptor eluded investigators until recently. Now with the identification of the previously orphaned GPCR, GPR160, as a receptor for CART, focus on this pluripotent neuropeptide will in all likelihood experience a renaissance and the potential for the development of pharmcotherapies targeting GPR160 seems within reach.
Published: 2021

45. Imaging the Source Region of the 2015 Phreatic Eruption at Owakudani, Hakone Volcano, Japan, Using High‐Density Audio‐Frequency Magnetotellurics

Author: Yohei Yukutake, Kazutaka Mannen, Yuki Abe, Wataru Kanda, M. Harada, M. Fukai, Masahiro Ishikawa, Rina Noguchi, Shinichi Takakura, Takao Koyama, and Kaori Seki
Subjects: geography, Geophysics, geography.geographical_feature_category, Volcano, Magnetotellurics, General Earth and Planetary Sciences, High density, Geology, Seismology, Phreatic eruption, Audio frequency
Published: 2021

46. Impact of Blood Pressure Visit‐to‐Visit Variability on Adverse Events in Patients With Nonvalvular Atrial Fibrillation: Subanalysis of the J‐RHYTHM Registry

Author: Eitaro Kodani, Hiroshi Inoue, Hirotsugu Atarashi, Ken Okumura, Takeshi Yamashita, Toshiaki Otsuka, Hideki Origasa, H Inoue, K Okumura, H Atarashi, T Yamashita, M Sakurai, Y Kawamura, I Kubota, Y Kaneko, K Matsumoto, S Ogawa, Y Aizawa, I Kodama, E Watanabe, Y Koretsune, Y Okuyama, A Shimizu, O Igawa, S Bando, M Fukatani, T Saikawa, A Chishaki, H Origasa, N Kato, K. Kanda, J Kato, H Obata, M Aoki, H. Honda, Y Konta, T Hatayama, Y Abe, K Terata, T Yagi, A Ishida, T Komatsu, H Tachibana, H Suzuki, Y Kamiyama, T Watanabe, M Oguma, M Itoh, O Hirono, Y Tsunoda, K Ikeda, T Kanaya, K Sakurai, H Sukekawa, S Nakada, T Itoh, S Tange, M. Manita, M Ohta, H Eguma, R Kato, Y Endo, T Ogino, M Yamazaki, H Kanki, M Uchida, S Miyanaga, K Shibayama, N Toratani, T Kojima, M Ichikawa, M Saito, Y Umeda, T Sawanobori, H Sohara, S Okubo, T Okubo, T. Tokunaga, O Kuboyama, H Ito, Y Kitahara, K Sagara, T Satoh, E Kodani, K Sugi, Y Kobayashi, Y Higashi, T Katoh, Y Hirayama, N Matsumoto, M Takano, T Ikeda, S Yusu, S Niwano, Y Nakazato, Y Kawano, M Sumiyoshi, N Hagiwara, K Murasaki, H Mitamura, S Nakagawa, K Okishige, K Azegami, H Aoyagi, K Sugiyama, M Nishizaki, N Yamawake, I Watanabe, K Ohkubo, H Sakurada, S Fukamizu, M Suzuki, W Nagahori, T Nakamura, Y Murakawa, N Hayami, K Yoshioka, M Amino, K Hirao, A Yagishita, K Ajiki, K Fujiu, Y Imai, A Yamashina, T Ishiyama, M Sakabe, K Nishida, H Asanoi, H Ueno, null Lee, Y Mitsuke, H Furushima, K Ebe, M Tagawa, M Sato, M. Morikawa, K Yamashiro, K Takami, T Ozawa, M Watarai, M Yamauchi, H Kamiya, H. Hirayama, Y. Yoshida, T Murohara, Y Inden, H Osanai, N Ohte, T Goto, I Morishima, T Yamamoto, E Fujii, M Senga, H. Hayashi, T Urushida, Y Takada, N Tsuboi, T Noda, T Hirose, T Onodera, S Kageyama, T Osaka, T. Tomita, K Shimada, M Nomura, H Izawa, A Sugiura, T Arakawa, K. Kimura, T Mine, T Makita, H Mizuno, A Kobori, T Haruna, M Takagi, N Tanaka, H Shimizu, T Kurita, K Motoki, N Takeda, Y Kijima, M Ito, A Nakata, Y Ueda, A Hirata, S Kamakura, K Satomi, Y. Yamada, Y. Yoshiga, H Ogawa, M Kimura, T Hayano, T Kinbara, H Tatsuno, M Harada, K. Kusano, M Adachi, A Yano, M Sawaguchi, J Yamasaki, T Matsuura, Y Tanaka, H Moritani, T Maki, S Okada, M Takechi, T Hamada, A Nishikado, Y Takagi, I Matsumoto, T Soeki, Y Doi, M Okawa, H Seo, S Kitamura, K Yamamoto, M Akizawa, N Kaname, S Ando, S Narita, T Inou, Y Fukuizumi, K Saku, M Ogawa, Y Urabe, M Ikeuchi, S Harada, H Yamabe, Y Imamura, Y. Yamanouchi, K Sadamatsu, K Yoshida, T Kubota, N Takahashi, N Makino, Y Higuchi, T Ooie, T Iwao, K. Kitamura, T Imamura, K Maemura, N Komiya, M Hayano, H Yoshida, and K. Kumagai
Subjects: Male, medicine.medical_specialty, Hemorrhage, Risk Assessment, Rhythm, Japan, Risk Factors, Cause of Death, Thromboembolism, Internal medicine, Atrial Fibrillation, Ambulatory Care, medicine, Humans, Arrhythmia and Electrophysiology, In patient, Registries, Risk factor, Adverse effect, Original Research, Aged, Analysis of Variance, variability, Clinical events, business.industry, blood pressure, Anticoagulants, Blood Pressure Determination, Atrial fibrillation, medicine.disease, Blood pressure, major hemorrhage, Hypertension, Cardiology, Female, Warfarin, Cardiology and Cardiovascular Medicine, business, Platelet Aggregation Inhibitors
Abstract: Background Blood pressure (BP) variability has reportedly been a risk factor for various clinical events. To clarify the influence of BP visit‐to‐visit variability on adverse events in patients with nonvalvular atrial fibrillation, a post hoc analysis of the J‐RHYTHM Registry was performed. Methods and Results Of 7406 outpatients with nonvalvular atrial fibrillation from 158 institutions, 7226 (age, 69.7±9.9 years; men, 70.7%), in whom BP was measured 4 times or more (14.6±5.0 times) during the 2‐year follow‐up period or until occurrence of an event, constituted the study group. SD and coefficient of variation of BP values were calculated as BP variability. Thromboembolism, major hemorrhage, and all‐cause death occurred in 110 (1.5%), 121 (1.7%), and 168 (2.3%) patients, respectively. When patients were divided into quartiles of systolic BP‐SD (P =0.015 for thromboembolism; HR, 2.60, 95% CI, 1.36–4.97, P =0.004 for major hemorrhage; and HR, 1.85, 95% CI, 1.11–3.07, P =0.018 for all‐cause death) after adjusting for components of the CHA 2 DS 2 ‐VASc score, warfarin and antiplatelet use, atrial fibrillation type, BP measurement times, and others. These findings were consistent when BP‐coefficient of variation was used instead of BP‐SD. Conclusions Systolic BP visit‐to‐visit variability was significantly associated with all adverse events in patients with nonvalvular atrial fibrillation. Further studies are needed to clarify the causality between BP variability and adverse outcomes in patients with nonvalvular atrial fibrillation. Registration URL: https://www.umin.ac.jp/ctr/ ; Unique Identifier: UMIN000001569.
Published: 2021

47. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Author: D. KLIONSKY, A. ABDEL-AZIZ, S. ABDELFATAH, M. ABDELLATIF, A. ABDOLI, S. ABEL, H. ABELIOVICH, M. ABILDGAARD, Y. ABUDU, A. ACEVEDO-AROZENA, I. ADAMOPOULOS, K. ADELI, T. ADOLPH, A. ADORNETTO, E. AFLAKI, G. AGAM, A. AGARWAL, B. AGGARWAL, M. AGNELLO, P. AGOSTINIS, J. AGREWALA, A. AGROTIS, P. AGUILAR, S. AHMAD, Z. AHMED, U. AHUMADA-CASTRO, S. AITS, S. AIZAWA, Y. AKKOC, T. AKOUMIANAKI, H. AKPINAR, A. AL-ABD, L. AL-AKRA, A. AL-GHARAIBEH, M. ALAOUI-JAMALI, S. ALBERTI, E. ALCOCER-GOMEZ, C. ALESSANDRI, M. ALI, M. AL-BARI, S. ALIWAINI, J. ALIZADEH, E. ALMACELLAS, A. ALMASAN, A. ALONSO, G. ALONSO, N. ALTAN-BONNET, D. ALTIERI, S. ALVES, C. DA COSTA, M. ALZAHARNA, M. AMADIO, C. AMANTINI, C. AMARAL, S. AMBROSIO, A. AMER, V. AMMANATHAN, Z. AN, S. ANDERSEN, S. ANDRABI, M. ANDRADE-SILVA, A. ANDRES, S. ANGELINI, D. ANN, U. ANOZIE, M. ANSARI, P. ANTAS, A. ANTEBI, Z. ANTON, T. ANWAR, L. APETOH, N. APOSTOLOVA, T. ARAKI, Y. ARAKI, K. ARASAKI, W. ARAUJO, J. ARAYA, C. ARDEN, M. AREVALO, S. ARGUELLES, E. ARIAS, J. ARIKKATH, H. ARIMOTO, A. ARIOSA, D. ARMSTRONG-JAMES, L. ARNAUNE-PELLOQUIN, A. AROCA, D. ARROYO, I. ARSOV, R. ARTERO, D. ASARO, M. ASCHNER, M. ASHRAFIZADEH, O. ASHUR-FABIAN, A. ATANASOV, A. AU, P. AUBERGER, H. AUNER, L. AURELIAN, R. AUTELLI, L. AVAGLIANO, Y. AVALOS, S. AVEIC, C. AVELEIRA, T. AVINWITTENBERG, Y. AYDIN, S. AYTON, S. AYYADEVARA, M. AZZOPARDI, M. BABA, J. BACKER, S. BACKUES, D. BAE, O. BAE, S. BAE, E. BAEHRECKE, A. BAEK, S. BAEK, G. BAGETTA, A. BAGNIEWSKA-ZADWORNA, H. BAI, J. BAI, X. BAI, Y. BAI, N. BAIRAGI, S. BAKSI, T. BALBI, C. BALDARI, W. BALDUINI, A. BALLABIO, M. BALLESTER, S. BALAZADEH, R. BALZAN, R. BANDOPADHYAY, S. BANERJEE, Y. BAO, M. BAPTISTA, A. BARACCA, C. BARBATI, A. BARGIELA, D. BARILA, P. BARLOW, S. BARMADA, E. BARREIRO, G. BARRETO, J. BARTEK, B. BARTEL, A. BARTOLOME, G. BARVE, S. BASAGOUDANAVAR, D. BASSHAM, R. JR, A. BASU, H. BATOKO, I. BATTEN, E. BAULIEU, B. BAUMGARNER, J. BAYRY, R. BEALE, I. BEAU, F. BEAUMATIN, L. BECHARA, G. 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ZHANG, W. ZHANG, X. ZHANG, Y. ZHANG, Z. ZHANG, H. ZHAO, L. ZHAO, S. ZHAO, T. ZHAO, X. ZHAO, Y. ZHAO, G. ZHENG, K. ZHENG, L. ZHENG, S. ZHENG, X. ZHENG, Y. ZHENG, Z. ZHENG, B. ZHIVOTOVSKY, Q. ZHONG, A. ZHOU, B. ZHOU, C. ZHOU, G. ZHOU, H. ZHOU, J. ZHOU, K. ZHOU, R. ZHOU, X. ZHOU, Y. ZHOU, Z. ZHOU, B. ZHU, C. ZHU, G. ZHU, H. ZHU, W. ZHU, Y. ZHU, H. ZHUANG, X. ZHUANG, K. ZIENTARA-RYTTER, C. ZIMMERMANN, E. ZIVIANI, T. ZOLADEK, W. ZONG, D. ZOROV, A. ZORZANO, W. ZOU, Z. ZOU, S. ZURYN, W. ZWERSCHKE, B. BRAND-SABERI, C. KENCHAPPA, S. OSHIMA, Y. RONG, J. SLUIMER, and C. STALLINGS
Subjects: flux, macroautophagy, phagophore, stress, vacuole, Autophagosome, LC3, lysosome, neurodegeneration, cancer
Abstract: In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.
Published: 2021

48. X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis

Author: S. Abiru, John F. Dillon, Yasuhiro Miyake, Piero Portincasa, Giancarlo Spinzi, R. Harvey, T. Ngatchu, Agostino Colli, M. Taniai, K. Flahive, Masanori Abe, B. Hoeroldt, S. Holder, Howard Curtis, María Isabel Colombo, C. MacNicol, Gang Xie, Andrew Chilton, H. Hussaini, Cristina Rigamonti, M. Kato, Shintaro Yagi, G. Abouda, D. Tyrer, Chris D. Evans, Christopher I. Amos, K. Koss, Kazuaki Chayama, P. Premchand, K. Migita, Simon Panter, Marco Marzioni, Silvia Colombo, Konstantinos N. Lazaridis, M. Yagura, Ashley Brown, D. Gocher, Domenico Alvaro, K. Murata, Mark Wright, Piero Luigi Almasio, C. Healey, A. Ciaccio, N. Wheatley, Vincenzo Cardinale, T. Delahooke, Chiara Milani, T. Shewan, W. Stableforth, S. Levi, Mark L. Green, James V. Jones, Y. Baird, Aftab Ala, Burroughs Ak, D. Williams, K. Ario, P. Sanghi, Hemant Gupta, P. Southern, L. Farrington, M. Hamilton, Andrew D. Higham, I. Yabuuchi, H. Yatsuhashi, Lorenzo Morini, T. Yamamoto, Douglas Thorburn, M. Carnahan, N. Nishida, Susan Slininger, M. Koga, K. Honda, Annarosa Floreani, Andrew Douglass, K. Netherton, M. Yasunami, Hirohito Tsubouchi, F. Donato, K. Walker, U. Shmueli, Paolo Muratori, Ray Mathew, J. Maiden, E. Dungca, Subramaniam Ramakrishnan, S. Vyas, Helen Sweeting, Subrata Saha, T. Komeda, T. Komatsu, H. J. Lee, Maria Consiglia Bragazzi, T. Komura, C. Thomas, C. Shallcross, C. Duggan, J. Kordula, F. Muscariu, Lourdes Cumlat, Imran Patanwala, Giulia Cardamone, L. Morgan, J. Brighton, Masao Honda, H. Nakamura, David Jones, Raj Srirajaskanthan, M. E. Gershwin, T. Muro, L. Stafford, N. Fukushima, Graham P. Butcher, Andrea Crosignani, George Lipscomb, K. Hirata, Y. Nagaoki, S. Mann, Paul G. Richardson, David A Elphick, M. Mupudzi, Y. Ohara, E. Grieve, Gayle Clifford, Claudio Tiribelli, M. Quinn, G. Van Duyvenvoorde, E. Archer, Tatsuki Ichikawa, J. Maltby, T. Arinaga-Hino, Simon Williams, A. King, Yasuni Nakanuma, H. Doyle, A. Brind, Nora Cazzagon, H. Ota, Daphne D’Amato, K. Hogben, H. Wooldridge, J. Wilkins, Shuichi Kaneko, L. Hankey, Gordon Wood, Andrew Fraser, K. Martin, A. Naqvi, M. Ninkovic, M. Patel, Yoshihiko Maehara, Kapil Kapur, I. Amey, Vincenza Calvaruso, Kenichi Harada, T. Yamashita, James Neuberger, N. Taylor, T. Lee, J. Featherstone, C. Lawlor, K. Seward, Satoshi Yamagiwa, Andrea Galli, L. Tan, Kentaro Kikuchi, K. Furuta, Mark A. Ainsworth, Hiromasa Ohira, Esther Unitt, Yosuke Kawai, N. Lancaster, D. Simpson, R. Shidrawi, I. Salam, A.J. Bell, Pietro Andreone, J. Ishida, Voi Shim Wong, N Fisher, Andrew C. Douds, R. Penn, Matthew Foxton, A. Watson, Andrew Mason, S. Walsh, Hiromi Ishibashi, Daniel M. Forton, Giovanni Casella, H. Takaki, K. Yamauchi, Pietro Lampertico, Osamu Yokosuka, M. Koda, M. Davies, H. Mitchison, P. Gyawali, G. Bird, M. Hughes, L. Jones, C. Hamilton, A. Hynes, R. Galaska, Fabio Marra, Debasish Das, C. Cowley, A. Fouracres, Yasuhiko Sugawara, E. Mita, T. Saoshiro, Akinobu Taketomi, Robert P. Myers, R. Przemioslo, F. Wright, L. Hobson, L. Currie, J. Allison, J. Hails, Noriyo Yamashiki, Massimo Zuin, C. Grimley, Alessio Gerussi, S. Besley, Stefano Duga, A. Piotrowicz, H. Kouno, L. Dali-kemmery, H. Sakai, M. Mizokami, Stefano Fagiuoli, Amy Davis, Pier Maria Battezzati, Masao Nagasaki, Luigi Muratori, A. Mori, S. Desmennu, S. Jones, R. Abrahams, Keith George, F. Makita, J. Brown, D. Gorard, Satoru Joshita, M. Mills, Pierluigi Toniutto, S. Campbell, J. Butterworth, S. Dyer, Filomena Morisco, Norihiro Kokudo, T. Yapp, C. Shorrock, Floriano Rosina, E. Walker, Shinji Uemoto, H. Takahashi, Simon M. Rushbrook, K. Amor, E. Marshall, J. Browning, S. Batham, Luca Fabris, Paul R. Banim, Meenakshi Narain, M. Harada, Dermot Gleeson, N. Hirashima, M. Kikuchi, T. Nikami, Gideon M. Hirschfield, Carlo Ferrari, G. Prasad, O. Chirag, Katsushi Tokunaga, M. Nasseri, Rosanna Asselta, Y. Lu, Ken Shirabe, D. Sirdefield, George F. Mells, K. Sugi, R. Ayres, G. Whatley, A. Singhal, M. Leoni, N. Sivaramakrishnan, T. 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Gordon, Shotaro Sakisaka, A. Dias, Chin Lye Ch'ng, M. Carter, A. Mandal, Yufang Shi, Takafumi Ichida, N. Masaki, M. Oblak, S. Nagaoka, Kevin Yoong, O. Gervais, Minoru Nakamura, Kazuhiko Nakao, S. Taylor-Robinson, L. Kent, Sushma Saksena, A. Affronti, K. Boulton, R. Ede, H. Pateman, K. Yoshizawa, G. Bray, H. Ebinuma, Yeng Ang, Akio Ido, John Ramage, Richard Sturgess, C. Gray, E. Durant, M. Hayes, A. Saeed, J. Keggans, J. Gitahi, T. Valliani, Edoardo G. Giannini, C. Foale, A. Palegwala, Lory Saveria Crocè, K. Matsushita, S. Shaukat, J. Mclindon, S. Pearson, A. Barnardo, A. Wright, Mirko Tarocchi, R Marley, M. Kent, C. Dickson, A. Gibbins, J. Whiteman, S. Singhal, Richard Aspinall, M. Ito, Laura Cristoferi, Maurizia Rossana Brunetto, J. Booth, A. Bathgate, Morikazu Onji, A. Grant, A. Paton, Y. Aiba, P. Chan, J. Sayer, S. Whalley, T. Mathialahan, J. Gotto, T. Kanda, B. Williams, K. Elliott, P. Raymode, Akinobu Takaki, V. Silvestre, I. Gee, C. Hovell, Graham R. Foster, D. Cotterill, G. 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D., Collier, J., Klass, H., Ninkovic, M., Cramp, M., Sharer, N., Aspinall, R., Goggin, P., Ghosh, D., Douds, A., Hoeroldt, B., Booth, J., Williams, E., Hussaini, H., Stableforth, W., Ayres, R., Thorburn, D., Marshall, E., Burroughs, A., Mann, S., Lombard, M., Richardson, P., Patanwala, I., Maltby, J., Brookes, M., Mathew, R., Vyas, S., Singhal, S., Gleeson, D., Misra, S., Butterworth, J., George, K., Harding, T., Douglass, A., Panter, S., Shearman, J., Bray, G., Butcher, G., Forton, D., Mclindon, J., Cowan, M., Whatley, G., Mandal, A., Gupta, H., Sanghi, P., Jain, S., Pereira, S., Prasad, G., Watts, G., Wright, M., Neuberger, J., Gordon, F., Unitt, E., Grant, A., Delahooke, T., Higham, A., Brind, A., Cox, M., Ramakrishnan, S., King, A., Collins, C., Whalley, S., Li, A., Fraser, J., Bell, A., Wong, V. 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F., Invernizzi, P., Asselta R., Paraboschi E.M., Gerussi A., Cordell H.J., Mells G.F., Sandford R.N., Jones D.E., Nakamura M., Ueno K., Hitomi Y., Kawashima M., Nishida N., Tokunaga K., Nagasaki M., Tanaka A., Tang R., Li Z., Shi Y., Liu X., Xiong M., Hirschfield G., Siminovitch K.A., Walker E., Xie G., Mason A., Myers R., Peltekian K., Ghent C., Atkinson E., Juran B., Lazaridis K., Lu Y., Gu X., Jing K., Amos C., Affronti A., Brunetto M., Coco B., Spinzi G., Elia G., Ferrari C., Lleo A., Muratori L., Muratori P., Portincasa P., Colli A., Bruno S., Colloredo G., Azzaroli F., Andreone P., Bragazzi M., Alvaro D., Cardinale V., Cazzagon N., Rigamonti C., Floreani A., Rosina F., Ciaccio A., Cristoferi L., D'Amato D., Malinverno F., Mancuso C., Massironi S., Milani C., O'Donnell S.E., Ronca V., Barisani D., Lampertico P., Donato F., Fagiuoli S., Almasio P.L., Giannini E., Cursaro C., Colombo M., Valenti L., Miele L., Andriulli A., Niro G.A., Grattagliano I., Morini L., Casella G., Vinci M., Battezzati P.M., Crosignani A., Zuin M., Mattalia A., Calvaruso V., Colombo S., Benedetti A., Marzioni M., Galli A., Marra F., Tarocchi M., Picciotto A., Morisco F., Fabris L., Croce L.S., Tiribelli C., Toniutto P., Strazzabosco M., Ch'ng C.L., Rahman M., Yapp T., Sturgess R., Healey C., Czajkowski M., Gunasekera A., Gyawali P., Premchand P., Kapur K., Marley R., Foster G., Watson A., Dias A., Subhani J., Harvey R., McCorry R., Ramanaden D., Gasem J., Evans R., Mathialahan T., Shorrock C., Lipscomb G., Southern P., Tibble J., Gorard D., Palegwala A., Jones S., Dawwas M., Alexander G., Dolwani S., Prince M., Foxton M., Elphick D., Mitchison H., Gooding I., Karmo M., Saksena S., Mendall M., Patel M., Ede R., Austin A., Sayer J., Hankey L., Hovell C., Fisher N., Carter M., Koss K., Piotrowicz A., Grimley C., Neal D., Lim G., Levi S., Ala A., Broad A., Saeed A., Wood G., Brown J., Wilkinson M., Gordon H., Ramage J., Ridpath J., Ngatchu T., Grover B., Shaukat S., Shidrawi R., Abouda G., Ali F., Rees I., Salam I., Narain M., Brown A., Taylor-Robinson S., Williams S., Grellier L., Banim P., Das D., Chilton A., Heneghan M., Curtis H., Gess M., Drake I., Aldersley M., Davies M., Jones R., McNair A., Srirajaskanthan R., Pitcher M., Sen S., Bird G., Barnardo A., Kitchen P., Yoong K., Chirag O., Sivaramakrishnan N., MacFaul G., Jones D., Shah A., Evans C., Saha S., Pollock K., Bramley P., Mukhopadhya A., Fraser A., Mills P., Shallcross C., Campbell S., Bathgate A., Shepherd A., Dillon J., Rushbrook S., Przemioslo R., Macdonald C., Metcalf J., Shmueli U., Davis A., Naqvi A., Lee T., Ryder S.D., Collier J., Klass H., Ninkovic M., Cramp M., Sharer N., Aspinall R., Goggin P., Ghosh D., Douds A., Hoeroldt B., Booth J., Williams E., Hussaini H., Stableforth W., Ayres R., Thorburn D., Marshall E., Burroughs A., Mann S., Lombard M., Richardson P., Patanwala I., Maltby J., Brookes M., Mathew R., Vyas S., Singhal S., Gleeson D., Misra S., Butterworth J., George K., Harding T., Douglass A., Panter S., Shearman J., Bray G., Butcher G., Forton D., Mclindon J., Cowan M., Whatley G., Mandal A., Gupta H., Sanghi P., Jain S., Pereira S., Prasad G., Watts G., Wright M., Neuberger J., Gordon F., Unitt E., Grant A., Delahooke T., Higham A., Brind A., Cox M., Ramakrishnan S., King A., Collins C., Whalley S., Li A., Fraser J., Bell A., Wong V.S., Singhal A., Gee I., Ang Y., Ransford R., Gotto J., Millson C., Bowles J., Thomas C., Harrison M., Galaska R., Kendall J., Whiteman J., Lawlor C., Gray C., Elliott K., Mulvaney-Jones C., Hobson L., Van Duyvenvoorde G., Loftus A., Seward K., Penn R., Maiden J., Damant R., Hails J., Cloudsdale R., Silvestre V., Glenn S., Dungca E., Wheatley N., Doyle H., Kent M., Hamilton C., Braim D., Wooldridge H., Abrahams R., Paton A., Lancaster N., Gibbins A., Hogben K., Desousa P., Muscariu F., Musselwhite J., McKay A., Tan L., Foale C., Brighton J., Flahive K., Nambela E., Townshend P., Ford C., Holder S., Palmer C., Featherstone J., Nasseri M., Sadeghian J., Williams B., Rolls S.-A., Hynes A., Duggan C., Crossey M., Stansfield G., MacNicol C., Wilkins J., Wilhelmsen E., Raymode P., Lee H.-J., Durant E., Bishop R., Ncube N., Tripoli S., Casey R., Cowley C., Miller R., Houghton K., Ducker S., Wright F., Bird B., Baxter G., Keggans J., Hughes M., Grieve E., Young K., Williams D., Ocker K., Hines F., Martin K., Innes C., Valliani T., Fairlamb H., Thornthwaite S., Eastick A., Tanqueray E., Morrison J., Holbrook B., Browning J., Walker K., Congreave S., Verheyden J., Slininger S., Stafford L., O'Donnell D., Ainsworth M., Lord S., Kent L., March L., Dickson C., Simpson D., Longhurst B., Hayes M., Shpuza E., White N., Besley S., Pearson S., Wright A., Jones L., Gunter E., Dewhurst H., Fouracres A., Farrington L., Graves L., Marriott S., Leoni M., Tyrer D., Dali-kemmery L., Lambourne V., Green M., Sirdefield D., Amor K., Colley J., Shinder B., Jones J., Mills M., Carnahan M., Taylor N., Boulton K., Tregonning J., Brown C., Clifford G., Archer E., Hamilton M., Curtis J., Shewan T., Walsh S., Warner K., Netherton K., Mupudzi M., Gunson B., Gitahi J., Gocher D., Batham S., Pateman H., Desmennu S., Conder J., Clement D., Gallagher S., Orpe J., Chan P., Currie L., O'Donohoe L., Oblak M., Morgan L., Quinn M., Amey I., Baird Y., Cotterill D., Cumlat L., Winter L., Greer S., Spurdle K., Allison J., Dyer S., Sweeting H., Kordula J., Aiba Y., Nakamura H., Abiru S., Nagaoka S., Komori A., Yatsuhashi H., Ishibashi H., Ito M., Kawai Y., Kohn S.-S., Gervais O., Migita K., Katsushima S., Naganuma A., Sugi K., Komatsu T., Mannami T., Matsushita K., Yoshizawa K., Makita F., Nikami T., Nishimura H., Kouno H., Ota H., Komura T., Nakamura Y., Shimada M., Hirashima N., Komeda T., Ario K., Nakamuta M., Yamashita T., Furuta K., Kikuchi M., Naeshiro N., Takahashi H., Mano Y., Tsunematsu S., Yabuuchi I., Shimada Y., Yamauchi K., Sugimoto R., Sakai H., Mita E., Koda M., Tsuruta S., Kamitsukasa H., Sato T., Masaki N., Kobata T., Fukushima N., Higuchi N., Ohara Y., Muro T., Takesaki E., Takaki H., Yamamoto T., Kato M., Nagaoki Y., Hayashi S., Ishida J., Watanabe Y., Kobayashi M., Koga M., Saoshiro T., Yagura M., Hirata K., Takikawa H., Ohira H., Zeniya M., Abe M., Onji M., Kaneko S., Honda M., Arai K., Arinaga-Hino T., Hashimoto E., Taniai M., Umemura T., Joshita S., Nakao K., Ichikawa T., Shibata H., Yamagiwa S., Seike M., Honda K., Sakisaka S., Takeyama Y., Harada M., Senju M., Yokosuka O., Kanda T., Ueno Y., Kikuchi K., Ebinuma H., Himoto T., Yasunami M., Murata K., Mizokami M., Shimoda S., Miyake Y., Takaki A., Yamamoto K., Hirano K., Ichida T., Ido A., Tsubouchi H., Chayama K., Harada K., Nakanuma Y., Maehara Y., Taketomi A., Shirabe K., Soejima Y., Mori A., Yagi S., Uemoto S., Tanaka T., Yamashiki N., Tamura S., Sugawara Y., Kokudo N., Carbone M., Cardamone G., Duga S., Gershwin M.E., Seldin M.F., Invernizzi P., Asselta, R, Paraboschi, E, Gerussi, A, Cordell, H, Mells, G, Sandford, R, Jones, D, Nakamura, M, Ueno, K, Hitomi, Y, Kawashima, M, Nishida, N, Tokunaga, K, Nagasaki, M, Tanaka, A, Tang, R, Li, Z, Shi, Y, Liu, X, Xiong, M, Hirschfield, G, Siminovitch, K, Walker, E, Xie, G, Mason, A, Myers, R, Peltekian, K, Ghent, C, Atkinson, E, Juran, B, Lazaridis, K, Lu, Y, Gu, X, Jing, K, Amos, C, Affronti, A, Brunetto, M, Coco, B, Spinzi, G, Elia, G, Ferrari, C, Lleo, A, Muratori, L, Muratori, P, Portincasa, P, Colli, A, Bruno, S, Colloredo, G, Azzaroli, F, Andreone, P, Bragazzi, M, Alvaro, D, Cardinale, V, Cazzagon, N, Rigamonti, C, Floreani, A, Rosina, F, Ciaccio, A, Cristoferi, L, D'Amato, D, Malinverno, F, Mancuso, C, Massironi, S, Milani, C, O'Donnell, S, Ronca, V, Barisani, D, Lampertico, P, Donato, F, Fagiuoli, S, Almasio, P, Giannini, E, Cursaro, C, Colombo, M, Valenti, L, Miele, L, Andriulli, A, Niro, G, Grattagliano, I, Morini, L, Casella, G, Vinci, M, Battezzati, P, Crosignani, A, Zuin, M, Mattalia, A, Calvaruso, V, Colombo, S, Benedetti, A, Marzioni, M, Galli, A, Marra, F, Tarocchi, M, Picciotto, A, Morisco, F, Fabris, L, Croce, L, Tiribelli, C, Toniutto, P, Strazzabosco, M, Ch'Ng, C, Rahman, M, Yapp, T, Sturgess, R, Healey, C, Czajkowski, M, Gunasekera, A, Gyawali, P, Premchand, P, Kapur, K, Marley, R, Foster, G, Watson, A, Dias, A, Subhani, J, Harvey, R, Mccorry, R, Ramanaden, D, Gasem, J, Evans, R, Mathialahan, T, Shorrock, C, Lipscomb, G, Southern, P, Tibble, J, Gorard, D, Palegwala, A, Jones, S, Dawwas, M, Alexander, G, Dolwani, S, Prince, M, Foxton, M, Elphick, D, Mitchison, H, Gooding, I, Karmo, M, Saksena, S, Mendall, M, Patel, M, Ede, R, Austin, A, Sayer, J, Hankey, L, Hovell, C, Fisher, N, Carter, M, Koss, K, Piotrowicz, A, Grimley, C, Neal, D, Lim, G, Levi, S, Ala, A, Broad, A, Saeed, A, Wood, G, Brown, J, Wilkinson, M, Gordon, H, Ramage, J, Ridpath, J, Ngatchu, T, Grover, B, Shaukat, S, Shidrawi, R, Abouda, G, Ali, F, Rees, I, Salam, I, Narain, M, Brown, A, Taylor-Robinson, S, Williams, S, Grellier, L, Banim, P, Das, D, Chilton, A, Heneghan, M, Curtis, H, Gess, M, Drake, I, Aldersley, M, Davies, M, Jones, R, Mcnair, A, Srirajaskanthan, R, Pitcher, M, Sen, S, Bird, G, Barnardo, A, Kitchen, P, Yoong, K, Chirag, O, Sivaramakrishnan, N, Macfaul, G, Shah, A, Evans, C, Saha, S, Pollock, K, Bramley, P, Mukhopadhya, A, Fraser, A, Mills, P, Shallcross, C, Campbell, S, Bathgate, A, Shepherd, A, Dillon, J, Rushbrook, S, Przemioslo, R, Macdonald, C, Metcalf, J, Shmueli, U, Davis, A, Naqvi, A, Lee, T, Ryder, S, Collier, J, Klass, H, Ninkovic, M, Cramp, M, Sharer, N, Aspinall, R, Goggin, P, Ghosh, D, Douds, A, Hoeroldt, B, Booth, J, Williams, E, Hussaini, H, Stableforth, W, Ayres, R, Thorburn, D, Marshall, E, Burroughs, A, Mann, S, Lombard, M, Richardson, P, Patanwala, I, Maltby, J, Brookes, M, Mathew, R, Vyas, S, Singhal, S, Gleeson, D, Misra, S, Butterworth, J, George, K, Harding, T, Douglass, A, Panter, S, Shearman, J, Bray, G, Butcher, G, Forton, D, Mclindon, J, Cowan, M, Whatley, G, Mandal, A, Gupta, H, Sanghi, P, Jain, S, Pereira, S, Prasad, G, Watts, G, Wright, M, Neuberger, J, Gordon, F, Unitt, E, Grant, A, Delahooke, T, Higham, A, Brind, A, Cox, M, Ramakrishnan, S, King, A, Collins, C, Whalley, S, Li, A, Fraser, J, Bell, A, Wong, V, Singhal, A, Gee, I, Ang, Y, Ransford, R, Gotto, J, Millson, C, Bowles, J, Thomas, C, Harrison, M, Galaska, R, Kendall, J, Whiteman, J, Lawlor, C, Gray, C, Elliott, K, Mulvaney-Jones, C, Hobson, L, Van Duyvenvoorde, G, Loftus, A, Seward, K, Penn, R, Maiden, J, Damant, R, Hails, J, Cloudsdale, R, Silvestre, V, Glenn, S, Dungca, E, Wheatley, N, Doyle, H, Kent, M, Hamilton, C, Braim, D, Wooldridge, H, Abrahams, R, Paton, A, Lancaster, N, Gibbins, A, Hogben, K, Desousa, P, Muscariu, F, Musselwhite, J, Mckay, A, Tan, L, Foale, C, Brighton, J, Flahive, K, Nambela, E, Townshend, P, Ford, C, Holder, S, Palmer, C, Featherstone, J, Nasseri, M, Sadeghian, J, Williams, B, Rolls, S, Hynes, A, Duggan, C, Crossey, M, Stansfield, G, Macnicol, C, Wilkins, J, Wilhelmsen, E, Raymode, P, Lee, H, Durant, E, Bishop, R, Ncube, N, Tripoli, S, Casey, R, Cowley, C, Miller, R, Houghton, K, Ducker, S, Wright, F, Bird, B, Baxter, G, Keggans, J, Hughes, M, Grieve, E, Young, K, Williams, D, Ocker, K, Hines, F, Martin, K, Innes, C, Valliani, T, Fairlamb, H, Thornthwaite, S, Eastick, A, Tanqueray, E, Morrison, J, Holbrook, B, Browning, J, Walker, K, Congreave, S, Verheyden, J, Slininger, S, Stafford, L, O'Donnell, D, Ainsworth, M, Lord, S, Kent, L, March, L, Dickson, C, Simpson, D, Longhurst, B, Hayes, M, Shpuza, E, White, N, Besley, S, Pearson, S, Wright, A, Jones, L, Gunter, E, Dewhurst, H, Fouracres, A, Farrington, L, Graves, L, Marriott, S, Leoni, M, Tyrer, D, Dali-kemmery, L, Lambourne, V, Green, M, Sirdefield, D, Amor, K, Colley, J, Shinder, B, Jones, J, Mills, M, Carnahan, M, Taylor, N, Boulton, K, Tregonning, J, Brown, C, Clifford, G, Archer, E, Hamilton, M, Curtis, J, Shewan, T, Walsh, S, Warner, K, Netherton, K, Mupudzi, M, Gunson, B, Gitahi, J, Gocher, D, Batham, S, Pateman, H, Desmennu, S, Conder, J, Clement, D, Gallagher, S, Orpe, J, Chan, P, Currie, L, O'Donohoe, L, Oblak, M, Morgan, L, Quinn, M, Amey, I, Baird, Y, Cotterill, D, Cumlat, L, Winter, L, Greer, S, Spurdle, K, Allison, J, Dyer, S, Sweeting, H, Kordula, J, Aiba, Y, Nakamura, H, Abiru, S, Nagaoka, S, Komori, A, Yatsuhashi, H, Ishibashi, H, Ito, M, Kawai, Y, Kohn, S, Gervais, O, Migita, K, Katsushima, S, Naganuma, A, Sugi, K, Komatsu, T, Mannami, T, Matsushita, K, Yoshizawa, K, Makita, F, Nikami, T, Nishimura, H, Kouno, H, Ota, H, Komura, T, Nakamura, Y, Shimada, M, Hirashima, N, Komeda, T, Ario, K, Nakamuta, M, Yamashita, T, Furuta, K, Kikuchi, M, Naeshiro, N, Takahashi, H, Mano, Y, Tsunematsu, S, Yabuuchi, I, Shimada, Y, Yamauchi, K, Sugimoto, R, Sakai, H, Mita, E, Koda, M, Tsuruta, S, Kamitsukasa, H, Sato, T, Masaki, N, Kobata, T, Fukushima, N, Higuchi, N, Ohara, Y, Muro, T, Takesaki, E, Takaki, H, Yamamoto, T, Kato, M, Nagaoki, Y, Hayashi, S, Ishida, J, Watanabe, Y, Kobayashi, M, Koga, M, Saoshiro, T, Yagura, M, Hirata, K, Takikawa, H, Ohira, H, Zeniya, M, Abe, M, Onji, M, Kaneko, S, Honda, M, Arai, K, Arinaga-Hino, T, Hashimoto, E, Taniai, M, Umemura, T, Joshita, S, Nakao, K, Ichikawa, T, Shibata, H, Yamagiwa, S, Seike, M, Honda, K, Sakisaka, S, Takeyama, Y, Harada, M, Senju, M, Yokosuka, O, Kanda, T, Ueno, Y, Kikuchi, K, Ebinuma, H, Himoto, T, Yasunami, M, Murata, K, Mizokami, M, Shimoda, S, Miyake, Y, Takaki, A, Yamamoto, K, Hirano, K, Ichida, T, Ido, A, Tsubouchi, H, Chayama, K, Harada, K, Nakanuma, Y, Maehara, Y, Taketomi, A, Shirabe, K, Soejima, Y, Mori, A, Yagi, S, Uemoto, S, Tanaka, T, Yamashiki, N, Tamura, S, Sugawara, Y, Kokudo, N, Carbone, M, Cardamone, G, Duga, S, Gershwin, M, Seldin, M, Invernizzi, P, Asselta R, Paraboschi EM, Gerussi A, Cordell HJ, Mells GF, Sandford RN, Jones DE, Nakamura M, Ueno K, Hitomi Y, Kawashima M, Nishida N, Tokunaga K, Nagasaki M, Tanaka A, Tang R, Li Z, Shi Y, Liu X, Xiong M, Hirschfield G, Siminovitch KA, Canadian-US PBC Consortium, Italian PBC Genetics Study Group, UK-PBC Consortium, Japan PBC-GWAS Consortium, Carbone M, Cardamone G, Duga S, Gershwin ME, Seldin MF, Invernizzi P, and LiveR North
Subjects: Canadian-US PBC Consortium, 0301 basic medicine, Male, Linkage disequilibrium, Genome-wide association study, Disease, PBC, Settore MED/03 - GENETICA MEDICA, Linkage Disequilibrium, 0302 clinical medicine, UK-PBC Consortium, Genotype, Mitochondrial Precursor Protein Import Complex Proteins, Italian PBC Genetics Study Group, Odds Ratio, X-Wide Association Study, Japan PBC-GWAS Consortium, X chromosome, Genetics, Liver Cirrhosis, Biliary, Gastroenterology, Forkhead Transcription Factors, DNA-Binding Proteins, Shal Potassium Channels, 030211 gastroenterology & hepatology, Female, Adult, Monosaccharide Transport Proteins, Superenhancer, Locus (genetics), Single-nucleotide polymorphism, Biology, Protein Serine-Threonine Kinases, Polymorphism, Single Nucleotide, Article, White People, 03 medical and health sciences, Asian People, Proto-Oncogene Proteins, Endopeptidases, Humans, Cell Lineage, Genetic Predisposition to Disease, Meta-analysi, Genetic association, Chromosomes, Human, X, Gastroenterology & Hepatology, Hepatology, 1103 Clinical Sciences, Meta-analysis, 030104 developmental biology, Genetic Loci, 1114 Paediatrics and Reproductive Medicine, 1109 Neurosciences, Carrier Proteins, Genome-Wide Association Study
Abstract: Background & aims: Genome-wide association studies in primary biliary cholangitis (PBC) have failed to find X chromosome (chrX) variants associated with the disease. Here, we specifically explore the chrX contribution to PBC, a sexually dimorphic complex autoimmune disease. Methods: We performed a chrX-wide association study, including genotype data from 5 genome-wide association studies (from Italy, United Kingdom, Canada, China, and Japan; 5244 case patients and 11,875 control individuals). Results: Single-marker association analyses found approximately 100 loci displaying P < 5 × 10-4, with the most significant being a signal within the OTUD5 gene (rs3027490; P = 4.80 × 10-6; odds ratio [OR], 1.39; 95% confidence interval [CI], 1.028-1.88; Japanese cohort). Although the transethnic meta-analysis evidenced only a suggestive signal (rs2239452, mapping within the PIM2 gene; OR, 1.17; 95% CI, 1.09-1.26; P = 9.93 × 10-8), the population-specific meta-analysis showed a genome-wide significant locus in East Asian individuals pointing to the same region (rs7059064, mapping within the GRIPAP1 gene; P = 6.2 × 10-9; OR, 1.33; 95% CI, 1.21-1.46). Indeed, rs7059064 tags a unique linkage disequilibrium block including 7 genes: TIMM17B, PQBP1, PIM2, SLC35A2, OTUD5, KCND1, and GRIPAP1, as well as a superenhancer (GH0XJ048933 within OTUD5) targeting all these genes. GH0XJ048933 is also predicted to target FOXP3, the main T-regulatory cell lineage specification factor. Consistently, OTUD5 and FOXP3 RNA levels were up-regulated in PBC case patients (1.75- and 1.64-fold, respectively). Conclusions: This work represents the first comprehensive study, to our knowledge, of the chrX contribution to the genetics of an autoimmune liver disease and shows a novel PBC-related genome-wide significant locus.
Published: 2021

49. Search for tens of MeV neutrinos associated with gamma-ray bursts in Super-Kamiokande

Author: P. Fernandez, Y. Nishimura, M. Inomoto, J. Bian, P. de Perio, G. Pronost, L. Wan, M. Lamoureux, Shintaro Ito, S. Zsoldos, Y. Takeuchi, K. Martens, J. Xia, Y. Sonoda, O. Drapier, Takatomi Yano, S. El Hedri, T. Shiozawa, Ahmed Ali, Ll. Marti, K. Nakamura, C. Xu, Hiroaki Menjo, C. Bronner, A. Konaka, T. Sekiguchi, K. S. Ganezer, M. Hartz, A. Giampaolo, B. Jamieson, N. F. Calabria, J. G. Learned, Takaaki Kajita, K. Yasutome, S. Nakayama, A. Takenaka, M. Harada, Vincenzo Berardi, William R. Kropp, S. Chen, R. G. Park, L. Ludovici, Kimihiro Okumura, Yasuhiro Takemoto, K. M. Tsui, A. Takeda, Hiromasa Tanaka, C. W. Walter, H. Okazawa, K. Okamoto, Y. Ashida, J. McElwee, S. Izumiyama, D. Barrow, Y. Fukuda, M. Ikeda, R. P. Litchfield, T. Okada, Intae Yu, N. Ogawa, Kate Scholberg, H. Miyabe, G. D. Megias, C. Simpson, Makoto Sakuda, L. Bernard, S. Samani, M. G. Catanesi, J. Y. Yang, Masaki Ishitsuka, M. Thiesse, F. d. M. Blaszczyk, Jl Stone, Yoshitaka Kuno, G. Pintaudi, K. Ohta, Hiroyuki Sekiya, F. Nova, Y. Kato, P. Weatherly, K. Abe, S. Han, T. Sugimoto, Hirokazu Ishino, Masayuki Nakahata, N. McCauley, C. M. Nantais, B. Zaldivar, T. Nakadaira, S. Sakai, E. Kearns, A. Goldsack, Michael B. Smy, M. Jakkapu, R. A. Wendell, Y. Uchida, M. Posiadala-Zezula, Y. Oyama, B. Bodur, C. Vilela, G. De Rosa, K. Sato, G. Collazuol, Luis Labarga, J. Kameda, J. Feng, D. Fukuda, T. Niwa, P. Mijakowski, P. Paganini, B. D. Xu, N. J. Griskevich, P. Mehta, T. Horai, C. K. Jung, Lester D.R. Thompson, Yusuke Koshio, D. Bravo-Berguño, S. Matsuno, T. Tsukamoto, K. Hagiwara, S. Hirota, M. Koshiba, Y. Nakajima, G.D. Barr, Yuuki Nakano, T. Mochizuki, Stephen J. Jenkins, I. T. Lim, T. Ishida, Y. Isobe, L. N. Machado, T. Boschi, John Walker, Th. A. Mueller, Hiroshi Ito, B. W. Pointon, M. Taani, R. Akutsu, A. A. Sztuc, Makoto Hasegawa, L. H. V. Anthony, Tatsuya Kikawa, Volodymyr Takhistov, Yousuke Kataoka, N. W. Prouse, S. V. Cao, A. Pritchard, M. Tsukada, M. Gonin, Yoshihiro Suzuki, Y. Nagao, A. Minamino, M. Shinoki, M. Malek, J. Y. Kim, J. L. Raaf, S. Yamamoto, T. Nakamura, S. Locke, M. Jiang, A. Coffani, Yasuhiro Kishimoto, O. Stone, Takashi Kobayashi, T. Towstego, T. Hasegawa, S. Mine, Takahiko Matsubara, K. Frankiewicz, N. Piplani, A. Orii, Mark R. Vagins, S. B. Kim, A. K. Ichikawa, K. E. Nakamura, S. Molina Sedgwick, B. Richards, Ken Sakashita, W. Ma, R. Matsumoto, B. Quilain, J. F. Martin, M. Friend, Masato Shiozawa, Y. Choi, L. Cook, A. Suzuki, Masashi Yokoyama, T. Ishizuka, Tsuyoshi Nakaya, J. S. Jang, Masahiro Kuze, R. Sasaki, Henry W. Sobel, Kyoshi Nishijima, Natalv Ospina, Shigetaka Moriyama, H. A. Tanaka, S. Imaizumi, K. Iwamoto, T. Tashiro, Manabu Tanaka, Yoshinari Hayato, C. Yanagisawa, T. Wester, Yoshitaka Itow, M. Miura, M. J. Wilking, Takashi Yoshida, F. Iacob, E. Radicioni, John Hill, D. L. Wark, Y. Takahira, R. Wang, M. Mori, F. Di Lodovico, Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Super-Kamiokande, and Super-Kamiokande Collaboration
Subjects: Astrophysics::High Energy Astrophysical Phenomena, General Physics and Astronomy, FOS: Physical sciences, Astrophysics, KAMIOKANDE, gamma ray: burst, 01 natural sciences, Fluence, Coincidence, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), Positron, F03 Ultra-high energy phenomena of cosmic rays, neutrino: energy, 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], 010303 astronomy & astrophysics, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), 010308 nuclear & particles physics, background, High Energy Physics::Phenomenology, F22 Neutrinos from supernova remnant and other astronomical objects, network, positron, High Energy Physics::Experiment, C43 Underground experiments, Underground experiments Ultra-high energy phenomena of cosmic rays Neutrinos from supernova remnant and other astronomical objects, Neutrino, Astrophysics - High Energy Astrophysical Phenomena, Super-Kamiokande, Gamma-ray burst, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Energy (signal processing), Bar (unit)
Abstract: A search for neutrinos produced in coincidence with Gamma-Ray Bursts(GRB) was conducted with the Super-Kamiokande (SK) detector. Between December 2008 and March 2017, the Gamma-ray Coordinates Network recorded 2208 GRBs that occurred during normal SK operation. Several time windows around each GRB were used to search for coincident neutrino events. No statistically significant signal in excess of the estimated backgrounds was detected. The $\bar\nu_e$ fluence in the range from 8 MeV to 100 MeV in positron total energy for $\bar\nu_e+p\rightarrow e^{+}+n$ was found to be less than $\rm 5.07\times10^5$ cm$^{-2}$ per GRB in 90\% C.L. Upper bounds on the fluence as a function of neutrino energy were also obtained., Comment: 29 pages, 16 figures, 5 tables, accepted by PTEP
Published: 2021
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50. Follow-up of GWTC-2 gravitational wave events with neutrinos from the Super-Kamiokande detector

Author: Vincenzo Berardi, A. A. Sztuc, M. Thiesse, K. Iwamoto, P. Mehta, M. Koshiba, S. J. Jenkins, M. Taani, R. G. Park, H. Okazawa, Y. Takeuchi, Patrick de Perio, Kimihiro Okumura, K. Martens, S. Han, S. Cao, Thomas A. Mueller, E. Kearns, M. R. Vagins, David Hadley, Henry W. Sobel, Yoshinari Hayato, K. Yasutome, S. Mine, K. M. Tsui, Masashi Yokoyama, T. Towstego, C. Bronner, J. Y. Yang, Yasuhiro Takemoto, O. Drapier, J. McElwee, Gianfranca De Rosa, Makoto Miura, E. Radicioni, M. B. Smy, J. S. Jang, Shuhei Watanabe, A. Konaka, Marco Mattiazzi, David Wark, B. Zaldivar, J. Migenda, M. Lamoureux, T. Ishizuka, M. Friend, S. Zsoldos, B. Bodur, H. A. Tanaka, T. Matsubara, N. W. Prouse, Katsuki Hiraide, Tsuyoshi Nakaya, C. W. Walter, Masaki Ishitsuka, S. Locke, S. Miki, Hirokazu Ishino, J. Feng, Sonia El Hedri, Masahiro Kuze, Yusuke Koshio, John Walker, D. Barrow, S. Mohan Lakshmi, J. L. Raaf, M. Mori, Hiroaki Menjo, Y. Sonoda, F. Nova, S. Sano, R. Sasaki, Marcus O'Flaherty, Takaaki Kajita, Yoshitaka Itow, G. Collazuol, M. Jakkapu, Natalv Ospina, Mark Scott, Y. Nishimura, Hiroyuki Sekiya, Soo-Bong Kim, B. Quilain, James Hill, G. Pronost, M. Inomoto, Y. Fukuda, L. Wan, T. Yano, John Fraser Martin, I. T. Lim, T. Boschi, Y. Maekawa, K. Nakamura, M. J. Wilking, J. Bian, K. Abe, L. Bernard, Y. Nagao, A. Minamino, Tatsushi Kinoshita, S. Izumiyama, C. K. Jung, Hiroshi Ito, N. Jeff Griskevich, P. Paganini, Y. Kanemura, M. Ikeda, A. Giampaolo, Masato Shiozawa, L. Ludovici, B. D. Xu, Yoshihiro Suzuki, S. Moriyama, F. Iacob, M. Shinoki, M. Gonin, J. Xia, L. H. V. Anthony, Masayuki Nakahata, J. G. Learned, R. Matsumoto, Takuto Suganuma, Y. Uchida, A. Ali, Kate Scholberg, Pablo Fernandez, N. McCauley, L. N. Machado, H. K. Tanaka, S. Samani, M. Malek, M. G. Catanesi, Junjie Jiang, William R. Kropp, T. Sekiguchi, M. Harada, S. Chen, Kenzo Nakamura, H. Ozaki, S. Yamamoto, Yuuki Nakano, A. T. Suzuki, K. Okamoto, Hussain Kitagawa, B. Jamieson, G. D. Megias, B. W. Pointon, A. K. Ichikawa, T. Nakadaira, J. Kameda, Lester D.R. Thompson, Yuichi Oyama, V. Takhistov, P. Mijakowski, S. Sakai, T. Hasegawa, Atsushi Takeda, G. Pintaudi, Yasuhiro Nakajima, N. F. Calabria, Joanna Zalipska, K. Sakashita, T. Nakamura, N. Piplani, Intae Yu, N. Ogawa, M. Posiadala-Zezula, C. Yanagisawa, J. Y. Kim, A. Goldsack, S. Nakayama, R. A. Wendell, Y. Kataoka, A. Coffani, O. Stone, Takashi Kobayashi, D. Martin, K. Sato, G.D. Barr, Tatsuya Kikawa, L. Marti, M. Hartz, T. Tashiro, K. Nishijima, T. Wester, Justyna Lagoda, Jingyuan Gao, W. Ma, A. Takenaka, T. Tsukamoto, L. Labarga, T. Ishida, B. Richards, Shintaro Ito, Y. Kotsar, C. Vilela, FD Lodovico, L. Cook, R. Akutsu, Lamoureux, Mathieu, Abe, Ko, Bronner, Christophe, Hayato, Yoshinari, Hiraide, Katsuki, Ikeda, Motoyasu, Kameda, Jun, Kanemura, Yuki, Kataoka, Yousuku, Miki, Shintaro, Miura, Makoto, Moriyama, Shigetaka, Nagao, Yoshiki, Nakahata, Masayuki, Nakayama, Shoei, Okamoto, Kohei, Pronost, Guillaume, Sekiya, Hiroyuki, Shiozawa, Masato, Sonoda, Yutaro, Suzuki, Yoichiro, Takeda, Atsushi, Takemoto, Yasuhiro, Takenaka, Akira, Tanaka, Hidekazu, Watanabe, Shuhei, Yano, Takatomi, Han, Seungho, Kajita, Takaaki, Okumura, Kimihiro, Tashiro, Takuya, Xia, Junjie, Megias, Guillermo, Labarga, Lui, Marti, Llui, Zaldivar, Bryan, Pointon, Barry W., Kearns, Edward, Raaf, Jennifer L., Wan, Linyan, Wester, Thoma, Bian, Jianming, Griskevich, N. Jeff, Kropp, William R., Locke, Scott, Mine, Shunichi, Smy, Michael, Sobel, Henry W., Takhistov, Volodymyr, Hill, Jame, Kim, Jae Yool, Lim, In Taek, Park, Ryeong Gyoon, Bodur, Baran, Scholberg, Kate, Walter, Chri, Bernard, Laura, Coffani, Alice, Drapier, Olivier, El Hedri, Sonia, Giampaolo, Alberto, Gonin, Michel, Mueller, Thomas A., Paganini, Pascal, Quilain, Benjamin, Ishizuka, Takeharu, Nakamura, Taku, Jang, Jae Seung, Learned, John G., Cao, Son, Anthony, Lauren H. V., Martin, Daniel, Scott, Mark, Sztuc, Artur A., Uchida, Yoshi, Berardi, Vincenzo, Catanesi, Maria Gabriella, Radicioni, Emilio, Calabria, Nicola F., Machado, Lucas N., De Rosa, Gianfranca, Collazuol, Gianmaria, Iacob, Fabio, Mattiazzi, Marco, Ospina, Natalv, Ludovici, Lucio, Maekawa, Yuto, Nishimura, Yasuhiro, Friend, Megan, Hasegawa, Takuya, Ishida, Taku, Kobayashi, Takashi, Jakkapu, Mahesh, Matsubara, Tsunayuki, Nakadaira, Takeshi, Nakamura, Kenzo, Oyama, Yuichi, Sakashita, Ken, Sekiguchi, Tetsuro, Tsukamoto, Toshifumi, Boschi, Tommaso, Di Lodovico, Francesca, Gao, Jingyuan, Migenda, Jost, Taani, Mahdi, Zsoldos, Stephane, Nakano, Yuuki, Ozaki, Hironori, Suzuki, Atsumu, Takeuchi, Yasuo, Yamamoto, Shotaro, Kotsar, Yurii, Ali, Ajmi, Feng, Jiahui, Kikawa, Tatsuya, Mori, Masamitsu, Nakaya, Tsuyoshi, Wendell, Roger, Yasutome, Kenji, Fernández, Pablo, Mccauley, Neil, Mehta, Pruthvi, Tsui, Ka Ming, Fukuda, Yoshiyuki, Itow, Yoshitaka, Menjo, Hiroaki, Sato, Kazufumi, Lagoda, Justyna, Lakshmi, S. Mohan, Mijakowski, Piotr, Zalipska, Joanna, Jiang, Junjie, Jung, Chang K., Vilela, Cristovao, Wilking, Michael, Yanagisawa, Chiaki, Harada, Masayuki, Ishino, Hirokazu, Ito, Shintaro, Kitagawa, Hussain, Koshio, Yusuke, Ma, Wenjie, Piplani, Nishtha, Sakai, Seiya, Barr, Gile, Barrow, Danial, Cook, Laurence, Goldsack, Alexander, Samani, Soniya, Wark, David, Nova, Federico, Yang, Jeong Yeol, Jenkins, Sam J., Malek, Matthew, Mcelwee, Jordan, Stone, Owen, Thiesse, Matthew D., Thompson, Lee F., Okazawa, Hiroko, Kim, Soo Bong, Yu, Intae, Ichikawa, Atsuko, Nakamura, Kiseki, Nishijima, Kyoshi, Koshiba, Masatoshi, Iwamoto, Konosuke, Nakajima, Yasuhiro, Ogawa, Natsumi, Yokoyama, Masashi, Martens, Kai, Vagins, Mark, Kuze, Masahiro, Izumiyama, Shota, Inomoto, Michitaka, Ishitsuka, Masaki, Ito, Hiroshi, Kinoshita, Tatsushi, Matsumoto, Ryo, Shinoki, Masataka, Suganuma, Takuto, Martin, John Fraser, Tanaka, Hirohisa, Towstego, Trevor, Akutsu, Ryosuke, de Perio, Patrick, Hartz, Mark, Konaka, Akira, Prouse, Nick, Chen, Shaomin, Xu, Benda D., Posiadala-Zezula, Magdalena, Hadley, David, O'Flaherty, Marcu, Richards, Benjamin, Jamieson, Blair, Walker, John, Minamino, Akihiro, Pintaudi, Ggiorgio, Sano, Shiochi, and Sasaki, Ryota
Subjects: Physics, Particle physics, Gravitational wave, Cherenkov detector, Astrophysics::High Energy Astrophysical Phenomena, High Energy Physics::Phenomenology, Detector, Flux, law.invention, law, Time windows, High Energy Physics::Experiment, Total energy, Neutrino, Super-Kamiokande
Abstract: Super-Kamiokande (SK) is a 50-kt water Cherenkov detector, instrumented with $\sim 13$k photo-multipliers and running since 1996. It is sensitive to neutrinos with energies ranging from 4.5 MeV to several TeV. A new framework has been developed for the follow-up of gravitational wave (GW) alerts issued by the LIGO-Virgo collaboration (LVC). Neutrinos are searched for, using a 1000-second time window centered on the alert time and in both SK low-energy and high-energy samples. Such observation can then be used to constrain the neutrino emission from the GW source. The significance of potential signals has been obtained by comparing neutrino direction with the localization of the GW. The computation of limits on incoming neutrino flux and on the total energy emitted in neutrinos by the source has been performed for the different neutrino flavors. The results using the LVC GWTC-2 catalog (covering O3a period) are presented, as well as the outlooks for the future real-time public release of follow-ups for the O4 period (in 2022) and beyond.
Published: 2021

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