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The tumor of the orbital region is defined as a progressive and abnormal increase in the volume of the orbit, its contents or as a progressive, abnormal and simultaneous increase in the volume of these two structures, due to an excessive multiplication of tumor cells leading to a exophthalmos. The objective of this work is to study the clinical, paraclinical and therapeutic aspect of this lesion, and to identify the histological type of the tumor. It was Mrs. AD mother of a child, aged 19, with no known medical and surgical history; admitted on September 28, 2022 to the stomatology and maxillofacial surgery department of the Nianankoro Fomba hospital in Ségou for right ocular exophthalmos accompanied by pain and visual disturbance. Surgical treatment consisted of orbital exenteration, avoiding recurrences and postoperative superinfections and restoring the aesthetics of the face. The cytology result of the surgical specimen reveals a moderately differentiated sarcoma. Facial region tumors are lesions that aesthetically affect patients. Their prognosis and therapeutic follow-up after surgery depend on the histological type confirmed by cytological examination of the surgical specimen.

The sharing economy is a business model based on the idea of sharing underutilized resources or assets between individuals, rather than owning them individually. This concept has been widely applied in various industries such as transportation, accommodation, and equipment rental. Sharing economy platforms have disrupted traditional business models by creating new markets and providing greater access to goods and services. The performance of the sharing economy depends on the ability of companies to create trust, facilitate transactions, and ensure the safety and quality of the shared assets. While the sharing economy has brought benefits such as increased efficiency and sustainability, it has also raised concerns about regulation, labor rights, and the concentration of market power in the hands of a few large platforms.

Bone metastasis is frequent in bronchopulmonary cancer. We report a series of 52 patients, and analyze indications and the efficacy of surgery.We retrospectively studied the records of 52 patients operated on for spinal metastases of bronchopulmonary cancer over a 6-year period from January 2009 to December 2014 in the neurosurgery department of the North Hospital of Marseille, France.Mean age was 63.6years; with a sex ratio of 3:1 (M:F). Spinal pain associated with vertebral fracture and spinal cord compression was the most frequent clinical presentation (59.6%). SINS score was≥7 in 78.9% of cases. Karnofski Performance Status was average in 67.4% of cases. Predicted survival beyond 12months was zero according to the modified Tokuhashi score. The surgical indication was essentially palliative. Evolution showed regression of pain in 84.6% of cases, and stabilization and improvement in motor deficit in 80.6%. Median postoperative survival was 16months.Our results highlight the interest of surgery for pain relief, spinal stabilization and improvement in neurological function in patients with spinal metastases of bronchopulmonary cancer, and the unreliability of predictive survival scores.

Proliferating trichilemmal tumor (PTT) is an uncommon lesion that typically occurs on the scalp of older women. The risk factors which have been incriminated in the appearance of tumors of the scalp are: chronic sun exposure, the presence of sebaceous nevi, a history of ionizing radiation, burns, trauma or surgery of the scalp. CT can confirm the cystic and tissue nature of the lesion with the presence of calcifications, signs of locoregional invasion. The diagnosis of certainty is based on the anatomopathological study. The principle of treatment of TTP without the metastasis is a wide surgical excision with a margin of 1 cm in normal tissue. Endocranial extension and distant metastases are obstacles to surgical treatment. We report a rare case of scalp tumors in a hospital setting in a 75-year-old woman.

Resume L’agenesie pulmonaire est une malformation congenitale rare pouvant etre decouverte au decours des infections respiratoires. Un nourrisson de six mois issu d’une grossesse gemellaire est admis pour une detresse respiratoire avec hypoxie et asymetrie de l’auscultation pulmonaire. L’angioscanner thoracique revele une agenesie pulmonaire droite. L’evolution est favorable sous traitement avec neanmoins la persistance d’un stridor explore par une fibroscopie laryngee. Une corticotherapie inhalee au long cours a ete instauree dans le suivi. C’est un diagnostic rare qu’il faut savoir evoquer et qui justifie la realisation d’une radiographie pulmonaire au moindre doute.

Atmospheric stability conditions are known to impact the wind resource and yield assessments. However, they are too barely or not correctly taken into account in the industry due to several reasons such as limitations of commercial software or the relative inertia in updating industrial processes. This paper proposes a simplistic approach to improve wind resource and yield assessment certainty while keeping very similar software and industry processes. Two test cases are considered. First, the wind speed estimates made using a CFD software (Meteodyn 5.3) for different stability classes are compared to measurements obtained on a site with four met masts. Second, the wake losses obtained with a commercial yield assessment solver (WindPRO 3.5) considering different wake decay constant definitions are compared to SCADA data. In both cases, it appears that dividing the timeseries in “stability classes” and using corresponding stability parameters in the CFD and in the wake model parameters enable a reduction of the uncertainty. In the case of the energy estimation compared to SCADA, an improvement of 1.25% is obtained compared to the conventional approach.

Purpose: The purpose of this study was to determine HIV prevalence among participants admitted to the delivery room and recent birth attendants. Materials and Methods: This was a descriptive, cross-sectional, analytical study, with a prospective collection from February 1, 2018 to January 31, 2019 at fousseyni Daou Hospital in Kayes, Mali. Results: During our study period, we recorded 4269 deliveries. HIV-positive patients known before labour accounted for 0.21%. Four hundred and six participants received counselling/testing in the delivery room; of which 36 refused the test: 8.87% and 370 accepted or 91.13%. Thirteen patients tested positive or 3.51%. The 20 - 35 age group was the most represented at 76.92%. Positive patients tested received ARV treatment in the delivery room in 92.31% of cases; and 1 patient or 7.69% did not receive treatment for refusal. Vaginal delivery was the most common at 77%, with caesarean section 23%. Newborns had a good prognosis in their first weeks of life in 85%; fetal lethality was observed in 15% of newborns including 1 case of fresh stillbirth and 1 case of pediatric deaths for neonatal suffering. Conclusion: Counselling and voluntary HIV/AIDS testing during labour and immediate postpartum can detect many pregnant women who escape screening during antenatal consultations.

Secondary hypertrophic osteoarthropathy, or Pierre-Marie Bamberger syndrome, is characterized by the association of digital clubbing, polyarthritis and periostitis affecting the long bones. Most commonly it is a paraneoplastic syndrome associated with lung cancer in 80% of cases. We report the case of a 49-year-old female patient who is actively smoking, one pack per day for 20 years. Seen in consultation for pain and swelling of the hands, elbows, knees, ankles, and feet evolving for about 5 months, associated with a poorly differentiated pulmonary adenocarcinoma. On history, she told us about a weight loss of about 8 kg, no fever, no cough, no family history of inflammatory rheumatism or cancer. Bilateral digital clubbing was noted. The diagnosis was based on imaging and histology. Treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) and chemo-radiotherapy was started.

Objective: Rheumatologic disorders of chronic inflammatory bowel disease (IBD) and reactive arthritis with a digestive origin are part of the spondyloarthritis family. In black Africa, the prevalence of SpA associated with IBD is not clearly established. Thus the objective of our study was to describe the clinical and radiological characteristics of spondyloarthritis associated with IBD. Patients and Method: We carried out a prospective study in the rheumatology department of CHU Ignace Deen between January and December 2019. The diagnosis of SpA was based on clinical and biological arguments in accordance with the criteria of Amor and ASAS. Results: Fifteen observations of spondyloarthritis associated with IBD were collected in patients mean age 52 years with extremes of 32 and 65 years. 9 (53.33%) were female. Ten patients had Crohn’s disease (CD) and 5 had ulcerative colitis (UC). The mean number of pushes was 2.5 ± 1.2. The average diagnostic time was 46 months. Sacroiliitis was present in 73.3% of cases and the mean mSASSS score at diagnosis was 32.11/72. In total, corticosteroids were used in 9 (60%) of patients, NSAIDs in 26.6% while DMARDs salazopyrine and methotrexate in 33.3% and 20% of patients, respectively. Conclusion: The MICI and SpA association is undoubtedly underestimated in our regions. Better collaboration between rheumatologists and gastroenterologists could facilitate diagnosis and improve care.

Background: Mainly for economic reasons, histopathologic analysis is not a systematic practice in medical structures in Senegal, and the utility of this exam is being questioned by many authors. The purpose of this paper is to report the results of this exam, in our medical practice and try to determine if this exam should be systematic of kept only for individualized cases. Material and Methods: It was a retrospective study from January 2010 to December 2018, carried out in the Laboratory of Pathology of the Teaching Hospital of Grand Yoff in Dakar. The data were collected from the register of pathologic examinations of the laboratory. Results: We registered 543 results of histopathologic examination of products of conception from the first trimester abortion. The women mean age was 22.4 years ± 6.2 with extremes of 17 and 46 years. The routine histopathologic assessment of products of first- trimester miscarriages highlighted in our study three pathologies: hydatidiform mole (24.7%), infection (4.6%) and ectopic pregnancy (0.09%). Only 11.7% of cases of Hydatidiform mole (HM) were suspected before the histopathologic assessment. In our sample, molar pregnancy seems to be higher in anembryonic conception with a prevalence of 45%. The prevalence of Complete Hydatidiform Mole (CHM) was higher than the one of Partial Hydatidiform Mole (PHM) (14.8% vs. 9.9% of miscarriages). Indeed, both require follow up to prevent or manage at time the occurrence of choriocarcinoma. Conclusion: The results of the histologic analysis after abortion in the first trimester of pregnancy show that this exam should be practiced systematically in routine in our context because of high prevalence of hydatidiform mole.

Introduction: the roots of Leptadenia hastata, (L hastata) are remedies from the Senegalese pharmacopoeia and are as widely used as the leaves. However, few researchers have devoted themselves to their toxicity, unlike the leaves. However, in the traditional pharmacopoeia, the indications for use are very different. The aim of our study was to study the effect of the administration of methanolic extracts of roots of L hastata on renal tissue, using an animal model. Materials and Methods: a cohort of 18 rats was studied with a random distribution of the animals in 3 groups (n = 6). The first group was the control group. The treated groups (Group II and III) received the methanolic extract of L. hastata with an administration of 500 mg / kg / day and 1000 mg / kg / day respectively, for 28 days. Results: The dose of 1000 mg / kg / day was lethal in group III, from the first week in females. Serum creatinine was significantly higher in rats given the root extract. There was kidney damage with vacuolar degeneration starting at 500 mg / kg / day. The lesions were more severe in group III with glomerular involvement characterized by retraction in the renal corpuscles. Conclusion: If the leaves of L hastata seem to be safe for consumption according to the majority of authors in the literature, the roots of this same plant could be harmful. In addition to the lethality observed at the doses tested, the lesions in the renal parenchyma would be dose-dependent.

In the context of highly data-centric applications, close reconciliation of computation and storage should significantly reduce the energy-consuming process of data movement. This letter proposes a computational SRAM (C-SRAM) combining in- and near-memory computing (IMC/NMC) approaches to be used by a scalar processor as an energy-efficient vector processing unit. Parallel computing is thus performed on vectorized integer data on large words using usual logic and arithmetic operators. Furthermore, multiple rows can be advantageously activated simultaneously to increase this parallelism. The proposed C-SRAM is designed with a two-port pushed-rule foundry bitcell, available in most existing design platforms, and an adjustable form factor to facilitate physical implementation in a SoC. The 4-kB C-SRAM testchip of 128-b words manufactured in 22-nm FD-SOI process technology displays a subarray efficiency of 72% as well as an additional computing area of less than 5%. The measurements averaged on 10 dies at 0.85 V and 1 GHz demonstrate an energy efficiency per unit area of 35.6 and 1.48 TOPS/W/mm2 for 8-b additions and multiplications with 3- and 24-ns computing latency, respectively. Compared to a 128-b SIMD processor architecture, up to $2\times $ energy reduction and $1.8\times $ speed-up gains are achievable for a representative set of highly data-centric application kernels.

Tubal ligation is a surgical sterilization procedure that provides permanent and reliable contraception to women. Tubal obstruction is a method of permanent birth control that can be performed after mini-laparotomy under local anesthesia. Objective: To determine the outcome of tubal sterilizations by mini-laparotomy under local anesthesia performed in clients who underwent the surgical operation in the Maternity Ward of Ignace Deen National Hospital. Patients and Methods: The Gynecology and Obstetrics Department of Ignace Deen National Hospital was used as the place for the study. The study involved all the women seeking voluntary surgical contraception. This was a retrospective study of a descriptive type carried out from January 1, 2017 to December 31, 2018. A consent form was filled out and signed by spouses after an interview and a systematically carried out pre-operative clinical and para-clinical assessment. Results: During the study period, 56 tubal ligations were performed i.e. 4.72 percent of all family planning methods. The recruiting for the surgical contraception involved clients whose typical profile is that of women with an average age of 35, mostly housewives (35.71%), major multiparous (69.63%) with 6 living children on average. Married women made up the bulk of the recruiting i.e. 96.44%. Unmarried women made much more use of other methods. Indications of personal convenience were the most frequently encountered common reason. Among medical causes, high blood pressure concerned the majority of cases: 38% of the indications. Surgical contraception in between was more practiced than the post-partum one. The recorded complication was the parietal hematoma due to a lack of hemostasis and it accounted for 1.79% of cases. The progress was uncomplicated in 98.68% of cases. Forty couples (71.42%) expressed their feelings of satisfaction against only 6 cases of regret (10.71%). Conclusion: The surgical contraception has become a requirement for modern couples. Tubal ligation by mini-laparotomy is a simple operation and a harmless method of contraception that allows clients to use permanent contraception. Carried out on an outpatient basis, incidents and accidents are rare and may have psychological repercussions that are difficult to assess. The technical mastery of the gesture helps to minimize these incidents.

AIMS: To update and extend a previous cross-sectional international comparison of glycaemic control in people with type 1 diabetes.METHODS: Data were obtained for 520,392 children and adults with type 1 diabetes from 17 population and five clinic-based data sources in countries or regions between 2016 and 2020. Median HbA1c (IQR) and proportions of individuals with HbA1c < 58 mmol/mol (RESULTS: Median HbA1c varied from 55 to 79 mmol/mol (7.2 to 9.4%) across data sources and age groups so a pooled estimate was deemed inappropriate. OR (95% CI) for HbA1c < 58 mmol/mol (CONCLUSIONS: Glycaemic control of type 1 diabetes continues to vary substantially between age groups and data sources. While some improvement over time has been observed, glycaemic control remains sub-optimal for most people with Type 1 diabetes.

Type 1 diabetes is associated with an increased risk of vascular complications. We aimed to investigate the association between serum and tissue advanced glycation end-products (AGEs) and micro- and macrovascular complications in type 1 diabetes (T1D).We conducted a cross-sectional study on 196 adults with T1D (mean age 44.53 ± 16, mean duration of diabetes 22 ± 12 years, mean HbA1c 8 ± 1.2%). AGEs were measured in blood serum (i.e., carboxymethyllysine (CML), methylglyoxal-hydroimidazolone-1 (MGH1), and pentosidine) and by measurement of skin autofluorescence (SAF). Associations between AGEs levels and vascular complications were analyzed using binary logistic regression. Correlations between AGEs and pulse wave velocity (PWV) were also assessed by linear regressions. Significant differences were set for p values less than 0.05.We found positive associations between different AGEs and vascular complications. SAF was associated with both microangiopathy (retinopathy: OR = 1.92, p = 0.011; neuropathy: OR = 2.02, p = 0.04; any microangiopathy: OR = 2.83, p 0.0001) and macroangiopathy (coronaropathy: OR = 3.11, p = 0.009; any macroangiopathy: OR = 2.78, p = 0.003). For circulating AGEs, pentosidine was significantly associated with coronaropathy (OR = 1.61, p = 0.01) and any macroangiopathy (OR = 1.52, p = 0.005) while MGH1 was associated with nephropathy (OR 1.72, p = 0.03). Furthermore, a significant linear correlation was found between PWV and SAF (r = 0.43, p 0.001), pentosidine (r = 0.28, p 0.001), and MGH1 (r = 0.16, p = 0.031), but not for CML (r = 0.03, p = 0.598).Skin autofluorescence appears to be a useful marker for investigating both micro- and macrovascular complications in T1D. In this study, pentosidine was associated with macroangiopathy and MGH1 with nephropathy among the circulating AGEs. Furthermore, the correlations between PWV and AGEs may suggest their value in early prediction of vascular complications in T1D.

International audience; On-chip memories, and in particular SRAMs, are among the most critical components in terms of data security because they might contain sensitive data such as secret keys. Whenever a tampering event is detected, one should be able to erase efficiently and rapidly the full content of a memory holding such sensitive data, but current solutions based on simple power-off leadto very long erasure times. In this paper, we present a non-invasive design technique based on an innovative mechanism to remove electric charges from SRAM bitcells still powered on, beforerefreshing them with a new content not correlated with the previous one. The particularity of this novel hardware countermeasure is to be natively compatible with any SRAM circuit designed from pushed-rule foundry bitcells. We have designed and characterized an 8kB SRAM in 22nm FD-SOI process technology exploiting the proposed security strategy demonstrating an erase operation accomplished in the nanosecond time scale (versus 295$\mu$s with the conventional power-off solution) at the cost of an additional area of less than 5%. We have also shown that our solution is more efficient than a solution without prior erasure consisting in writing identical data to all memory addresses in a single clock cycle (1 ns). The use of the latter drops the ratio of zeroized addresses at 92%, while increasing the operating energy consumption by 2.1x under nominal operating conditions.

Resume Objectif Decrire les caracteristiques demographiques, cliniques, paracliniques et therapeutiques des patients ayant une dermatite atopique en Afrique sub-saharienne (SSA) et au Maghreb. Methodes Les medecins membres de la Federation Allergologie Internationale travaillant en Afrique sub-saharienne et au Maghreb ont ete invites a participer a cette etude transversale en incluant de facon consecutive les patientsatteints de dermatite atopique (DA) vus dans leurs consultations de septembre 2019 a janvier 2010 (5 mois). Resultats Au total, 69 patients (53,6 % de sexe feminin) ont ete inclus. La proportion des sujets de sexe feminin etait plus elevee chez les sujets inclus en Afrique SSA (69,7 % vs 38,9 %, p = 0,010). L’âge median (IIQ) etait de 8(2–23) ans. Au moins 3 zones corporelles etaient touchees chez 78,3 % des participants (72,7 % en Afrique SSA et 83,3 % au Maghreb). La somnolence diurne excessive a ete rapportee dans 31,9 % des cas. Quarante-huit patients (69,6 %) avaient une autre maladie cutanee associee notamment un prurigo simple (28 cas, 40,6 %) et une dermatite seborrheique (10 cas, 14,5 %). Les autres maladies allergiques les plus frequemment retrouvees chez nos patients etaient la rhinite allergique (55,1 %) et l’asthme (37,7 %). La prevalence de la sensibilisation aux aeroallergenes et aux allergenes alimentaires etait respectivement de 59,5 % et 40,6 %. Une surinfection bacterienne cutanee a ete exclusivement retrouvee chez 27,3 % des sujets africains. Conclusion Les caracteristiques cliniques classiquement decrites ont ete retrouvees avec en particulier une association de la DA avec d’autres maladies allergiques. La frequence de la surinfection bacterienne n’est pas negligeable.

INTRODUCTION : La DCV de la peau est une pratique courante chez les femmes en Afrique Subsaharienne avec une prévalence de 25 à 71%. Les principaux produits utilisés étaient les dermocorticoïdes d’activité très forte, l'hydroquinone et le mercure. Le CSC est très rare chez les patients atteints de phototype VI de Fitzpatrick. Depuis 2000, le premier cas de carcinome épidermoïde associé à une DCV de la peau a été rapporté par Addo à Accra, au Ghana. Nos objectifs étaient de décrire les cas de CSC survenus chez des femmes noires africaines vivant en Afrique Subsaharienne et d'en déterminer les facteurs associés. MATERIELS ET METHODES : Nous avons mené une étude descriptive multicentrique d'Août 2005 à Octobre 2021 au Mali, en Guinée, en Côte d'Ivoire et au Sénégal. Nous avons inclus tous les patients consultant pour un carcinome épidermoïde cutané associé à un blanchiment de la peau. Les données sociodémographiques, cliniques, paracliniques et thérapeutiques ont été enregistrées. RESULTATS : Au total 37 patientes ont été incluses. L'âge variait de 37 à 77 ans. L'hydroquinone topique et les corticoïdes très puissants ont été les principaux produits utilisés sur l'ensemble du corps, pendant une durée moyenne de 20,3 ans. Aucune maladie cutanée pré-néoplasique n'a été retrouvée chez nos patients. Les aspects cliniques des tumeurs étaient les suivants : ulcéro-bourgeonnant, ulcéré et nodulaire. Le délai moyen de développement avant consultation était de 6,75 mois. Les carcinomes épidermoïdes cutanés étaient localisés le plus souvent sur des lésions lichénoïdes ou des lésions ochronotiques exogènes sur les zones photo-exposées : visage, cou ou haut du dos. Un patient présente deux carcinomes épidermoïdes. Les aspects anatomo-pathologiques du carcinome épidermoïde étaient : la forme infiltrante, la forme invasive et le carcinome in situ. De plus, il existait des stigmates d’infection à HPV a l’histopathologie. L’exposition aux UV, l'immunosuppression et l'inflammation chronique sont certainement les principaux facteurs associés. Le facteur supplémentaire serait le virus HPV qui est oncogène. L'évolution était favorable chez la majorité des patients après résection chirurgicale. Quatre décès sont survenus. CONCLUSION : De 2000 à 2021, 37 cas de carcinomes épidermoïdes cutanés associés à l'utilisation cosmétique de produits de blanchiment ont été rapportés dans quatre pays d'Afrique Subsaharienne. Le mécanisme n'a pas été complètement élucidé et d'autres études sont nécessaires. Ces observations fournissent un argument supplémentaire pour lutter contre cette pratique et inclure le blanchiment de la peau parmi les facteurs de risque connus du carcinome épidermoïde.

INTRODUCTION : Le cancer de l’ovaire est un cancer dont la prise en charge est obligatoirement chirurgicale et la laparotomie est la voie d’abord par excellence. L’endoscopie planifiée dans la stratégie thérapeutique est d’un apport indéniable non seulement dans la confirmation diagnostique, mais également dans la décision opératoire d’emblée ou intervallaire. MATERIELS ET METHODES : Il s’agissait d’une collecte prospective et descriptive sur une période de six ans au Centre Hospitalier National de Pikine. Elle regroupe 53 cas de cancers avancés de l’ovaire ayant bénéficié d’un traitement chimiothérapique et ou d’une chirurgie cytoréductrice. Ont été incluses toutes les patientes ayant une tumeur de l’ovaire aux stades avancés (III et IV de la FIGO). Ainsi, toutes les patientes avaient bénéficié d’une cœlioscopie première, pour établir un diagnostic histologique et de décider de la stratégie finale de pris en charge. RESULTATS : L’âge moyen des patientes était de 50 ans avec des extrêmes de 18 et de 75 ans corrélé à un index de masse corporel moyen de 24 kg/m² de surface corporelle. Notre étude portait sur 53 patientes, dont 33 d’entre elles avaient eu à bénéficier d’une chirurgie. Parmi elles, 21 patientes, soit 39,6% étaient classés au stade IIIC de la FIGO. L’évaluation de la carcinose péritonéale était faite en utilisant le score de Fagotti et l’Index de Carcinose Péritonéale (PCI) de Sugarbaker. En se basant sur le score de Fagotti, la chirurgie était possible dans 15% des cas. En ce qui concerne l’index de carcinose péritonéale de Sugarbaker, 17 patientes avaient un score inférieur à huit, alors que six d’entre elles avaient un score supérieur à 18. Dans notre série, la qualité de la chirurgie était évaluée à l’aide de la « completeness cancer resection » (CCR score), ainsi le résidu tumoral était nul dans 90,9% alors que 9,1% avait un résidu tumoral dont la taille était inférieure à 2,5 cm. Dans notre série, huit patientes avaient un score d’Aletti bas, 12 patientes avaient un score d’Aletti intermédiaire alors celui était élevé dans 3% des cas. Parmi les patientes ayant eu une chirurgie complète, 11 étaient classés au stade FIGO IIIC, cinq présentaient un score PCI supérieure ou égale à 18, 10 avaient un score d’Aletti intermédiaire et seules deux avaient un score de Fagotti supérieure ou égale à huit. La cœlioscopie avait permis de prendre une décision jugée acceptable dans tous les cas, soit en chirurgie d’emblée première soit en chirurgie d’intervalle avec un taux de résidu R0 dans plus de 90% des cas. CONCLUSION : La cœlioscopie devient de plus en plus incontournable pour le diagnostic et la décision de résecabilité des patientes au stade avancé du cancer de l’ovaire. En diminuant la morbidité liée à une laparotomie diagnostique elle permet en outre de leur permettre une chimiothérapie néoadjuvante sans délai.