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1. 20789. DETECCIÓN DE LA ANGIOPATÍA AMILOIDE CEREBRAL (AAC) EN LA ENFERMEDAD DE ALZHEIMER (EA) MEDIANTE MARCADORES EN SANGRE

Author

M. Ricciardi Serra, E. Valeriano Lorenzo, M. Zea Sevilla, M. Valentí, B. Frades, I. López, M. Antón Moreno, A. Ruiz González, A. Pastor, S. Wagner, F. López González, P. Ruiz, L. Saiz, I. Burgueño García, M. López Martínez, A. Rábano, T. del Ser, and P. Sánchez Juan

Subjects
Neurology. Diseases of the nervous system, RC346-429
Published
2024
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3. Properties and technical characteristics of Casira pottery, Jujuy, Argentina

Author

A. Paltrinieri, M. F. Serra, M. S. Conconi, and N. M. Rendtorff

Subjects
popular ceramics, Casira, Argentina, properties, Engineering (General). Civil engineering (General), TA1-2040
Abstract

Abstract In this work, the results of a multi-technique characterization of a type of pottery production with high cultural and economic relevance from the only potter town in Argentina are presented and correlated. Raw materials, a prepared paste, and ceramic samples were studied. Chemical, structural, textural, microstructural, and thermal features were assessed and described in terms of the raw materials characteristics, fabrication, and firing conditions. Some distinctive properties of this Casira ceramic production, like the thermal expansion coefficient and other technological properties, are reported for the first time. This allowed the establishment of characteristic behaviors of the ceramics under study, which also constitute the basis for their traceability.

Published
2022
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4. Risk of Zika virus-associated birth defects in congenital confirmed cases in the Brazilian Amazon

Author

Consuelo S de Oliveira, Haroldo José de Matos, Francisco Luzio de Paula Ramos, Ana Yece das N Pinto, Priscila Nathyelly dos S Graim, Vivianne de Paula R Guimarães, Luna Thaís S Gomes, Emilene M. F Serra, Ana Cecília Cruz, Alessandra Leal, Daniele F. Henriques, Juliana A. Lima, Maura V. Anjos, Eliana V. Pinto, Alana W. de Souza, and Pedro Fernando da C. Vasconcelos

Subjects
zika virus infection, microcephaly, pregnancy complications, infectious, brazil, Medicine, Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270
Abstract

Objective. To establish the risk of microcephaly in neonates born to women infected with ZIKV during pregnancy. Methods. A cohort of laboratory-confirmed ZIKV cases of congenital infections (109 mothers infected during pregnancy and 101 newborns) among 308 suspect cases was followed in Belem, Pará, Brazil, from October 2015 to December 2017. Results. A microcephaly risk of 1.98% (95% CI 0.54-6.93%) was found, or 2 cases among the 101 neonates infected with ZIKV during pregnancy. 72% of the pregnant women had ZIKV infection confirmed by RT-qPCR during gestation. Conclusions. Results showed a low incidence of ZIKV-associated birth defects, stillbirth, and miscarriage, which contrasts with previous studies in other Brazilian regions. Previous exposure to yellow fever vaccine and/or multiserotype DENV infection could be implicated in the protection from ZIKV congenital infection.

Published
2020
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7. Central nervous system manganese induced lesions and clinical consequences in patients with hereditary hemorrhagic telangiectasia

Author

M. M. Serra, C. H. Besada, A. Cabana Cal, A. Saenz, C. V. Stefani, D. Bauso, A. B. Golimstok, J. C. Bandi, D. H. Giunta, and C. M. Elizondo

Subjects
Hepatic vascular malformations, Hereditary hemorrhagic telangiectasia, Basal ganglia manganese deposits, Iron deficiency anemia, Medicine
Abstract

Abstract Background Around 47–74% of patients with hereditary hemorrhagic telangiectasia (HHT) have hepatic vascular malformations (HVMs); magnetic resonance images (MRI) of the central nervous system (CNS) might show in T1 sequences a hyper-intensity signal in different areas, mainly in the basal ganglia (BG) as consequence of manganese (Mn) deposits as observed in cirrhotic patients. These patients might suffer from different neuropsychiatric disorders (hepatic encephalopathy). In HHT patients, even in the presence of hepatic shunts, hepatocellular function is usually preserved. Additionally, Mn shares iron absorption mechanisms, transferrin and CNS transferrin receptors. In iron deficiency conditions, the Mn may harbor transferrin and access BG. The objectives were to describe frequency of BG Mn deposit-induced lesions (BGMnIL) in HHT patients, its relationship with iron deficiency anemia (IDA) and HVMs. Finally, explore the association between neuropsychological and motor consequences. We performed a cross-sectional study. We determined HHT patients with or without BG-MnIL by the MRI screening of the CNS. We included all patients with lesions and a random sample of those without lesions. All patients underwent standardized and validated neuropsychological assessment to evaluate BG actions. Results were analyzed with multiple logistic regression, adjusting for potential confounders. Results Among 307 participants from a cohort included in the Institutional HHT Registry, 179 patients had MRI performed and Curaçao Criteria ≥3. The prevalence of BG-MnIL was 34.6% (95%CI 27.69-42.09). While neuropsychological symptoms were present in all patients, BG-MnIL patients performed poorly in three of the neuropsychological tests (serial dotting, line tracing time, number connection test A). HVMs frequency in BG-MnIL was 95.1%, versus 71.4% in those without lesions (p

Published
2017
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8. Reduced LPL and subcutaneous lipid storage capacity are associated with metabolic syndrome in postmenopausal women with obesity

Author

M. C. Serra, A. S. Ryan, and A. P. Goldberg

Subjects
Adipocyte hypertrophy, LPL activity, metabolic syndrome, visceral adipose tissue, Internal medicine, RC31-1245
Abstract

Sumary Objectives This study examines the hypothesis that lower adipose tissue lipoprotein lipase (LPL) activity and a limited capacity for subcutaneous adipocyte expansion will be associated with metabolic syndrome (MSyn) in postmenopausal women who are overweight and obese. Methods Women (N = 150; age 60 ± 1 year; BMI: 31.5 ± 0.3 kg m−2; mean ± standard errors of the means [SEM]) with and without MSyn had dual‐energy X‐ray absorptiometry scans for total body fat, CT scans for visceral and subcutaneous abdominal adipose tissue areas, lipid and glucose metabolic profiles, and abdominal and gluteal fat aspirations for subcutaneous fat cell weight (FCW; N = 150) and LPL activity (N = 100). Results Women with MSyn had similar total body fat, but 15% larger abdominal and 11% larger gluteal FCWs and more visceral fat (179 ± 7 vs. 134 ± 6 cm2) than women without MSyn (P's

Published
2017
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10. Determinants of host susceptibility to murine respiratory syncytial virus (RSV) disease identify a role for the innate immunity scavenger receptor MARCO gene in human infants

Author

Monica High, Hye-Youn Cho, Jacqui Marzec, Tim Wiltshire, Kirsten C. Verhein, Mauricio T. Caballero, Patricio L. Acosta, Jonathan Ciencewicki, Zackary R. McCaw, Lester Kobzik, Laura Miller-DeGraff, Wes Gladwell, David B. Peden, M. Elina Serra, Min Shi, Clarice Weinberg, Oscar Suzuki, Xuting Wang, Douglas A. Bell, Fernando P. Polack, and Steven R. Kleeberger

Subjects
Infectious disease, Innate immunity, Lung, Single nucleotide polymorphism, SNP, Promoter, Haplotype, Medicine, Medicine (General), R5-920
Abstract

Background: Respiratory syncytial virus (RSV) is the global leading cause of lower respiratory tract infection in infants. Nearly 30% of all infected infants develop severe disease including bronchiolitis, but susceptibility mechanisms remain unclear. Methods: We infected a panel of 30 inbred strains of mice with RSV and measured changes in lung disease parameters 1 and 5 days post-infection and they were used in genome-wide association (GWA) studies to identify quantitative trait loci (QTL) and susceptibility gene candidates. Findings: GWA identified QTLs for RSV disease phenotypes, and the innate immunity scavenger receptor Marco was a candidate susceptibility gene; targeted deletion of Marco worsened murine RSV disease. We characterized a human MARCO promoter SNP that caused loss of gene expression, increased in vitro cellular response to RSV infection, and associated with increased risk of disease severity in two independent populations of children infected with RSV. Interpretation: Translational integration of a genetic animal model and in vitro human studies identified a role for MARCO in human RSV disease severity. Because no RSV vaccines are approved for clinical use, genetic studies have implications for diagnosing individuals who are at risk for severe RSV disease, and disease prevention strategies (e.g. RSV antibodies).

Published
2016
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11. ESICM LIVES 2016: part one

Author

L. Bos, L. Schouten, L. van Vught, M. Wiewel, D. Ong, O. Cremer, A. Artigas, I. Martin-Loeches, A. Hoogendijk, T. van der Poll, J. Horn, N. Juffermans, M. Schultz, N. de Prost, T. Pham, G. Carteaux, A. Mekontso Dessap, C. Brun-Buisson, E. Fan, G. Bellani, J. Laffey, A. Mercat, L. Brochard, B. Maitre, LUNG SAFE investigators and the ESICM study group, P. A. Howells, D. R. Thickett, C. Knox, D. P. Park, F. Gao, O. Tucker, T. Whitehouse, D. F. McAuley, G. D. Perkins, LUNG SAFE Investigators and the ESICM Trials Group, L. Pisani, J. P. Roozeman, F. D. Simonis, A. Giangregorio, L. R. Schouten, S. M. Van der Hoeven, A. Serpa Neto, E. Festic, A. M. Dondorp, S. Grasso, L. D. Bos, M. J. Schultz, M. Koster-Brouwer, D. Verboom, B. Scicluna, K. van de Groep, J. Frencken, M. Bonten, J. I. Ko, K. S. Kim, G. J. Suh, W. Y. Kwon, K. Kim, J. H. Shin, O. T. Ranzani, E. Prina, R. Menendez, A. Ceccato, R. Mendez, C. Cilloniz, A. Gabarrus, M. Ferrer, A. Torres, A. Urbano, L. A. Zhang, D. Swigon, F. Pike, R. S. Parker, G. Clermont, C. Scheer, S. O. Kuhn, A. Modler, M. Vollmer, C. Fuchs, K. Hahnenkamp, S. Rehberg, M. Gründling, A. Taggu, N. Darang, N. Öveges, I. László, K. Tánczos, M. Németh, G. Lebák, B. Tudor, D. Érces, J. Kaszaki, W. Huber, D. Trásy, Z. Molnár, G. Ferrara, V. S. Kanoore Edul, H. S. Canales, E. Martins, C. Canullán, G. Murias, M. O. Pozo, J. F. Caminos Eguillor, M. G. Buscetti, C. Ince, A. Dubin, H. D. Aya, A. Rhodes, N. Fletcher, R. M. Grounds, M. Cecconi, M. Jacquet-Lagrèze, M. Riche, R. Schweizer, P. Portran, W. Fornier, M. Lilot, J. Neidecker, J. L. Fellahi, A. Escoresca-Ortega, A. Gutiérrez-Pizarraya, L. Charris-Castro, Y. Corcia-Palomo, E. Fernandez-Delgado, J. Garnacho-Montero, C. Roger, L. Muller, L. Elotmani, J. Lipman, J. Y. Lefrant, J. A. Roberts, R. Muñoz-Bermúdez, M. Samper, C. Climent, F. Vasco, V. Sara, S. Luque, N. Campillo, S. Grau Cerrato, J. R. Masclans, F. Alvarez-Lerma, S. Carvalho Brugger, G. Jimenez Jimenez, M. Miralbés Torner, J. Trujillano Cabello, B. Balsera Garrido, X. Nuvials Casals, F. Barcenilla Gaite, M. Vallverdú Vidal, M. Palomar Martínez, V. Gusarov, D. Shilkin, M. Dementienko, E. Nesterova, N. Lashenkova, A. Kuzovlev, M. Zamyatin, A. Demoule, S. Carreira, S. Lavault, O. Palancca, E. Morawiec, J. Mayaux, I. Arnulf, T. Similowski, B. S. Rasmussen, R. G. Maltesen, M. Hanifa, S. Pedersen, S. R. Kristensen, R. Wimmer, M. Panigada, G. Li Bassi, T. Kolobow, A. Zanella, M. Cressoni, L. Berra, V. Parrini, H. Kandil, G. Salati, S. Livigni, A. Amatu, A. Andreotti, F. Tagliaferri, G. Moise, G. Mercurio, A. Costa, A. Vezzani, S. Lindau, J. Babel, M. Cavana, D. Consonni, A. Pesenti, L. Gattinoni, for the GRAVITY-VAP TRIAL NETWORK, P. Mansouri, F. Zand, L. Zahed, F. Dehghanrad, M. Bahrani, M. Ghorbani, B. Cambiaghi, O. Moerer, T. Mauri, N. Kunze-Szikszay, C. Ritter, M. Quintel, L. M. Vilander, M. A. Kaunisto, S. T. Vaara, V. Pettilä, FINNAKI Study Group, J. L. G. Haitsma Mulier, S. Rozemeijer, A. M. E. Spoelstra-de Man, P. E. Elbers, P. R. Tuinman, M. C. de Waard, H. M. Oudemans-van Straaten, A. M. A. Liberatore, R. B. Souza, A. M. C. R. P. F. Martins, J. C. F. Vieira, I. H. J. Koh, M. Galindo Martínez, R. Jiménez Sánchez, L. Martínez Gascón, M. D. Rodríguez Mulero, A. Ortín Freire, A. Ojados Muñoz, S. Rebollo Acebes, Á. Fernández Martínez, S. Moreno Aliaga, L. Herrera Para, J. Murcia Payá, F. Rodríguez Mulero, P. Guerci, Y. Ince, P. Heeman, B. Ergin, Z. Uz, M. Massey, R. Papatella, E. Bulent, F. Toraman, E. R. Longbottom, H. D. Torrance, H. C. Owen, C. J. Hinds, R. M. Pearse, M. J. O’Dywer, Z. Trogrlic, M. van der Jagt, H. Lingsma, H. H. Ponssen, J. F. Schoonderbeek, F. Schreiner, S. J. Verbrugge, S. Duran, T. van Achterberg, J. Bakker, D. A. M. P. J. Gommers, E. Ista, A. Krajčová, P. Waldauf, F. Duška, A. Shah, N. Roy, S. McKechnie, C. Doree, S. Fisher, S. J. Stanworth, J. F. Jensen, D. Overgaard, M. H. Bestle, D. F. Christensen, I. Egerod, The RAPIT Group, A. Pivkina, I. Zhivotneva, N. Pasko, A. Alklit, R. L. Hansen, H. Knudsen, L. B. Grode, The RAPIT group, M. Hravnak, L. Chen, A. Dubrawski, M. R. Pinsky, S. M. Parry, L. D. Knight, B. C. Connolly, C. E. Baldwin, Z. A. Puthucheary, L. Denehy, N. Hart, P. E. Morris, J. Mortimore, C. L. Granger, H. I. Jensen, R. Piers, B. Van den Bulcke, J. Malmgren, V. Metaxa, A. K. Reyners, M. Darmon, K. Rusinova, D. Talmor, A. P. Meert, L. Cancelliere, L. Zubek, P. Maia, A. Michalsen, J. Decruyenaere, E. Kompanje, S. Vanheule, E. Azoulay, S. Vansteelandt, D. Benoit, C. Ryan, D. Dawson, J. Ball, K. Noone, B. Aisling, S. Prudden, A. Ntantana, D. Matamis, S. Savvidou, M. Giannakou, M. Gouva, G. Nakos, V. Koulouras, J. Aron, G. Lumley, D. Milliken, K. Dhadwal, B. A. McGrath, S. J. Lynch, B. Bovento, G. Sharpe, E. Grainger, S. Pieri-Davies, S. Wallace, B. McGrath, M. Jung, J. Cho, H. Park, G. Suh, O. Kousha, J. Paddle, L. Gamrin Gripenberg, M. Sundström Rehal, J. Wernerman, O. Rooyackers, H. J. de Grooth, W. P. Choo, A. M. Spoelstra-de Man, E. L. Swart, L. Talan, G. Güven, N. D. Altıntas, M. Padar, G. Uusvel, L. Starkopf, J. Starkopf, A. Reintam Blaser, M. S. Kalaiselvan, A. S. Arunkumar, M. K. Renuka, R. L. Shivkumar, M. Volbeda, D. ten Kate, M. Hoekstra, J. M. van der Maaten, M. W. Nijsten, A. Komaromi, Å. Norberg, M. Smedberg, M. Mori, L. Pettersson, M. Theodorakopoulou, T. Christodoulopoulou, A. Diamantakis, F. Frantzeskaki, M. Kontogiorgi, E. Chrysanthopoulou, M. Lygnos, C. Diakaki, A. Armaganidis, K. Gundogan, E. Dogan, R. Coskun, S. Muhtaroglu, M. Sungur, T. Ziegler, M. Guven, A. Kleyman, W. Khaliq, D. Andreas, M. Singer, R. Meierhans, R. Schuepbach, I. De Brito-Ashurst, G. Sabetian, R. Nikandish, F. Hagar, M. Masjedi, B. Maghsudi, A. Vazin, E. Asadpour, K. C. Kao, L. C. Chiu, C. Y. Hung, C. H. Chang, S. H. Li, H. C. Hu, S. El Maraghi, M. Ali, D. Rageb, M. Helmy, J. Marin-Corral, C. Vilà, A. Vàzquez, I. Martín-Loeches, E. Díaz, J. C. Yébenes, A. Rodriguez, F. Álvarez-Lerma, H1N1 SEMICYUC/GETGAG Working Group, N. Varga, A. Cortina-Gutiérrez, L. Dono, M. Martínez-Martínez, C. Maldonado, E. Papiol, M. Pérez-Carrasco, R. Ferrer, K. Nweze, B. Morton, I. Welters, M. Houard, B. Voisin, G. Ledoux, S. Six, E. Jaillette, S. Nseir, S. Romdhani, R. Bouneb, D. Loghmari, N. Ben Aicha, J. Ayachi, K. Meddeb, I. Chouchène, A. Khedher, M. Boussarsar, K. S. Chan, W. L. Yu, J. Nolla, L. Vidaur, J. Bonastre, B. Suberbiola, J. E. Guerrero, H1N1 SEMICYUC/GETGAG working group, N. Ramon Coll, G. Jiménez Jiménez, J. Codina Calero, M. García, M. C. de la Torre, E. Vendrell, E. Palomera, E. Güell, M. Serra-Prat, J. F. Bermejo-Martín, J. Almirall, E. Tomas, A. Escoval, F. Froe, M. H. Vitoria Pereira, N. Velez, E. Viegas, E. Filipe, C. Groves, M. Reay, A. Ballin, F. Facchin, G. Sartori, F. Zarantonello, E. Campello, C. M. Radu, S. Rossi, C. Ori, P. Simioni, N. Umei, I. Shingo, A. C. Santos, C. Candeias, I. Moniz, R. Marçal, Z. Costa e Silva, J. M. Ribeiro, J. F. Georger, J. P. Ponthus, M. Tchir, V. Amilien, M. Ayoub, E. Barsam, G. Martucci, G. Panarello, F. Tuzzolino, G. Capitanio, V. Ferrazza, T. Carollo, L. Giovanni, A. Arcadipane, M. López Sánchez, M. A. González-Gay, F. J. Llorca Díaz, M. I. Rubio López, E. Zogheib, L. Villeret, J. Nader, M. Bernasinski, P. Besserve, T. Caus, H. Dupont, P. Morimont, S. Habran, R. Hubert, T. Desaive, F. Blaffart, N. Janssen, J. Guiot, A. Pironet, P. Dauby, B. Lambermont, T. Pettenuzzo, G. Citton, C. Kirakli, O. Ediboglu, S. Ataman, M. Yarici, F. Tuksavul, S. Keating, A. Gibson, M. Gilles, M. Dunn, G. Price, N. Young, P. Remeta, P. Bishop, M. D. Fernández Zamora, J. Muñoz-Bono, E. Curiel-Balsera, E. Aguilar-Alonso, R. Hinojosa, A. Gordillo-Brenes, J. A. Arboleda-Sánchez, ARIAM-CARDIAC SURGERY PROJECT AUTHORS, I. Skorniakov, D. Vikulova, C. Whiteley, O. Shaikh, A. Jones, M. Ostermann, L. Forni, M. Scott, J. Sahatjian, W. Linde-Zwirble, D. Hansell, P. Laoveeravat, N. Srisawat, M. Kongwibulwut, S. Peerapornrattana, N. Suwachittanont, T. O. Wirotwan, P. Chatkaew, P. Saeyub, K. Latthaprecha, K. Tiranathanagul, S. Eiam-ong, J. A. Kellum, R. E. Berthelsen, A. Perner, A. E. K. Jensen, J. U. Jensen, D. J. Gebhard, J. Price, C. E. Kennedy, A. Akcan-Arikan, Y. R. Kang, M. N. Nakamae, K. Hamed, M. M. Khaled, R. Aly Soliman, M. Sherif Mokhtar, G. Seller-Pérez, D. Arias-Verdú, E. Llopar-Valdor, I. De-Diós-Chacón, G. Quesada-García, M. E. Herrera-Gutierrez, R. Hafes, G. Carroll, P. Doherty, C. Wright, I. G. Guerra Vera, M. Ralston, M. L. Gemmell, A. MacKay, E. Black, R. I. Docking, R. Appleton, M. R. Ralston, L. Gemmell, A. Mackay, J. G. Röttgering, P. W. G. Elbers, N. Mejeni, J. Nsiala, A. Kilembe, P. Akilimali, G. Thomas, A. E. Andersson, A. M. Fagerdahl, V. Knudsen, P-INFECT, A. Ben Cheikh, Y. Hamdaoui, A. Guiga, N. Fraj, N. Sma, I. Chouchene, N. Bouafia, A. Amirian, B. Ziaian, C. Fleischmann, D. O. Thomas-Rueddel, A. Schettler, D. Schwarzkopf, A. Stacke, K. Reinhart, A. Martins, P. Sousa, G. Snell, R. Matsa, T. T. S. Paary, A. M. Cavalheiro, L. L. Rocha, C. S. Vallone, A. Tonilo, M. D. S. Lobato, D. T. Malheiro, G. Sussumo, N. M. Lucino, V. D. Rosenthal, A. Sanaei Dashti, A. Yousefipour, J. R. Goodall, M. Williamson, E. Tant, N. Thomas, C. Balci, C. Gonen, E. Haftacı, H. Gurarda, E. Karaca, B. Paldusová, I. Zýková, D. Šímová, S. Houston, L. D’Antona, J. Lloyd, V. Garnelo-Rey, M. Sosic, V. Sotosek-Tokmazic, J. Kuharic, I. Antoncic, S. Dunatov, A. Sustic, C. T. Chong, M. Sim, T. Lyovarin, F. M. Acosta Díaz, S. Narbona Galdó, M. Muñoz Garach, O. Moreno Romero, A. M. Pérez Bailón, A. Carranza Pinel, M. Colmenero, A. Gritsan, A. Gazenkampf, E. Korchagin, N. Dovbish, R. M. Lee, M. P. P. Lim, B. C. L. Lim, J. J. See, R. Assis, F. Filipe, N. Lopes, L. Pessoa, T. Pereira, N. Catorze, M. S. Aydogan, C. Aldasoro, P. Marchio, A. Jorda, M. D. Mauricio, S. Guerra-Ojeda, M. Gimeno-Raga, M. Colque-Cano, A. Bertomeu-Artecero, M. Aldasoro, S. L. Valles, D. Tonon, T. Triglia, J. C. Martin, M. C. Alessi, N. Bruder, P. Garrigue, L. Velly, S. Spina, V. Scaravilli, C. Marzorati, E. Colombo, D. Savo, A. Vargiolu, G. Cavenaghi, G. Citerio, A. H. V. Andrade, P. Bulgarelli, J. A. P. Araujo, V. Gonzalez, V. A. Souza, C. Massant, C. A. C. Abreu Filho, R. A. Morbeck, L. E. Burgo, R. van Groenendael, L. T. van Eijk, G. P. Leijte, B. Koeneman, M. Kox, P. Pickkers, A. García-de la Torre, M. de la Torre-Prados, A. Fernández-Porcel, C. Rueda-Molina, P. Nuevo-Ortega, T. Tsvetanova-Spasova, E. Cámara-Sola, A. García-Alcántara, L. Salido-Díaz, X. Liao, T. Feng, J. Zhang, X. Cao, Q. Wu, Z. Xie, H. Li, Y. Kang, M. S. Winkler, A. Nierhaus, E. Mudersbach, A. Bauer, L. Robbe, C. Zahrte, E. Schwedhelm, S. Kluge, C. Zöllner, E. Mitsi, S. H. Pennington, J. Reine, A. D. Wright, R. Parker, I. D. Welters, J. D. Blakey, G. Rajam, E. W. Ades, D. M. Ferreira, D. Wang, A. Kadioglu, S. B. Gordon, R. Koch, J. Rahamat-Langedoen, J. Schloesser, M. de Jonge, J. Bringue, R. Guillamat-Prats, E. Torrents, M. L. Martinez, M. Camprubí-Rimblas, L. Blanch, S. Y. Park, Y. B. Park, D. K. Song, S. Shrestha, S. H. Park, Y. Koh, M. J. Park, C. W. Hong, O. Lesur, D. Coquerel, X. Sainsily, J. Cote, T. Söllradl, A. Murza, L. Dumont, R. Dumaine, M. Grandbois, P. Sarret, E. Marsault, D. Salvail, M. Auger-Messier, F. Chagnon, Apelin Group, M. P. Lauretta, E. Greco, A. Dyson, S. Preau, M. Ambler, A. Sigurta, S. Saeed, L. Topcu Sarıca, N. Zibandeh, D. Genc, F. Gul, T. Akkoc, E. Kombak, L. Cinel, I. Cinel, S. J. Pollen, N. Arulkumaran, G. Warnes, D. J. Pennington, K. Brohi, M. J. O’Dwyer, H. Y. Kim, S. Na, J. Kim, Y. F. Chang, A. Chao, P. Y. Shih, C. T. Lee, Y. C. Yeh, L. W. Chen, M. Adriaanse, W. Rietdijk, S. Funcke, S. Sauerlaender, B. Saugel, H. Pinnschmidt, D. A. Reuter, R. Nitzschke, S. Perbet, C. Biboulet, A. Lenoire, D. Bourdeaux, B. Pereira, B. Plaud, J. E. Bazin, V. Sautou, A. Mebazaa, J. M. Constantin, M. Legrand, Y. Boyko, P. Jennum, M. Nikolic, H. Oerding, R. Holst, P. Toft, H. K. Nedergaard, T. Haberlandt, S. Park, S. Kim, Y. J. Cho, Y. J. Lim, A. Chan, S. Tang, S. L. Nunes, S. Forsberg, H. Blomqvist, L. Berggren, M. Sörberg, T. Sarapohja, C. J. Wickerts, J. G. M. Hofhuis, L. Rose, B. Blackwood, E. Akerman, J. Mcgaughey, M. Fossum, H. Foss, E. Georgiou, H. J. Graff, M. Kalafati, R. Sperlinga, A. Schafer, A. G. Wojnicka, P. E. Spronk, F. Khalili, R. Afshari, H. Haddad Khodaei, S. Javadpour, P. Petramfar, S. Nasimi, H. Tabei, A. Gunther, J. O. Hansen, P. Sackey, H. Storm, J. Bernhardsson, Ø. Sundin, A. Bjärtå, A. Bienert, P. Smuszkiewicz, P. Wiczling, K. Przybylowski, A. Borsuk, I. Trojanowska, J. Matysiak, Z. Kokot, M. Paterska, E. Grzeskowiak, A. Messina, E. Bonicolini, D. Colombo, G. Moro, S. Romagnoli, A. R. De Gaudio, F. Della Corte, S. M. Romano, J. A. Silversides, E. Major, E. E. Mann, A. J. Ferguson, D. F. Mcauley, J. C. Marshall, J. A. Diaz-Rodriguez, R. Silva-Medina, E. Gomez-Sandoval, N. Gomez-Gonzalez, R. Soriano-Orozco, P. L. Gonzalez-Carrillo, M. Hernández-Flores, K. Pilarczyk, J. Lubarksi, D. Wendt, F. Dusse, J. Günter, B. Huschens, E. Demircioglu, H. Jakob, A. Palmaccio, A. M. Dell’Anna, D. L. Grieco, F. Torrini, C. Iaquaniello, F. Bongiovanni, M. Antonelli, L. Toscani, D. Antonakaki, D. Bastoni, M. Jozwiak, F. Depret, J. L. Teboul, J. Alphonsine, C. Lai, C. Richard, X. Monnet, G. Demeter, I. Kertmegi, A. Hasanin, A. Lotfy, A. El-adawy, H. Nassar, S. Mahmoud, A. Abougabal, A. Mukhtar, F. Quinty, S. Habchi, A. Luzi, E. Antok, G. Hernandez, B. Lara, L. Enberg, M. Ortega, P. Leon, C. Kripper, P. Aguilera, E. Kattan, M. Lehmann, S. Sakka, B. Bein, R. M. Schmid, J. Preti, J. Creteur, A. Herpain, J. Marc, F. Trojette, S. Bar, L. Kontar, D. Titeca, J. Richecoeur, B. Gelee, N. Verrier, R. Mercier, E. Lorne, J. Maizel, M. Slama, M. E. Abdelfattah, A. Eladawy, M. A. Ali Elsayed, A. Pedraza Montenegro, E. Monares Zepeda, J. Franco Granillo, J. S. Aguirre Sánchez, G. Camarena Alejo, A. Rugerio Cabrera, A. A. Tanaka Montoya, C. Lee, F. Hatib, M. Cannesson, P. Theerawit, T. Morasert, Y. Sutherasan, G. Zani, S. Mescolini, M. Diamanti, R. Righetti, A. Scaramuzza, M. Papetti, M. Terenzoni, C. Gecele, M. Fusari, K. A. Hakim, A. Chaari, M. Ismail, A. H. Elsaka, T. M. Mahmoud, K. Bousselmi, V. Kauts, W. F. Casey, S. D. Hutchings, D. Naumann, J. Wendon, S. Watts, E. Kirkman, Z. Jian, S. Buddi, J. Settels, P. Bertini, F. Guarracino, C. Trepte, P. Richter, S. A. Haas, V. Eichhorn, J. C. Kubitz, M. S. Soliman, W. I. Hamimy, A. Z. Fouad, A. M. Mukhtar, M. Charlton, L. Tonks, L. Mclelland, T. J. Coats, J. P. Thompson, M. R. Sims, D. Williams, D. Z. Roushdy, R. A. Soliman, R. A. Nahas, M. Y. Arafa, W. T. Hung, C. C. Chiang, W. C. Huang, K. C. Lin, S. C. Lin, C. C. Cheng, P. L. Kang, S. R. Wann, G. Y. Mar, C. P. Liu, M. Lopez Carranza, H. Sancho Fernandez, J. A. Sanchez Roman, F. Lucena, A. Campanario Garcia, A. Loza Vazquez, A. Lesmes Serrano, ARIAM-SEMICYUC Registry Investigators, L. Sayagues Moreira, R. Vidal-Perez, U. Anido Herranz, J. M. Garcia Acuna, C. Pena Gil, J. L. Garcia Allut, P. Rascado Sedes, C. Martin Lopez, E. Saborido Paz, C. Galban Rodriguez, J. R. Gonzalez-Juanatey, A. Vallejo-Baez, M. V. de la Torre-Prados, ARIAM Group, R. Marharaj, K. Gervasio, M. Bottiroli, M. Mondino, D. De Caria, A. Calini, E. Montrasio, F. Milazzo, M. P. Gagliardone, A. Vallejo-Báez, ARIAM group, U. Anido, M. Cheikh-Bouhlel, M. P. R. D. L. Dela Cruz, J. M. Bernardo, F. Galfo, A. Marino, C. C. Chao, P. Hou, C. C. Hung, C. H. Chiang, Y. J. Liou, S. M. Hung, Y. S. Lin, F. Y. Kuo, K. R. Chiou, C. J. Chen, L. S. Yan, C. Y. Liu, H. H. Wang, H. L. Chen, C. K. Ho, S. Grewal, S. Gopal, C. Corbett, A. Wilson, J. Capps, W. Ayoub, A. Lomas, S. Ghani, J. Moore, D. Atkinson, M. Sharman, W. Swinnen, J. Pauwels, K. Mignolet, E. Pannier, A. Koch, T. Sarens, W. Temmerman, A. M. Elmenshawy, A. M. Fayed, M. Elboriuny, E. Hamdy, E. Zakaria, A. C. Falk, A. Petosic, K. Olafsen, H. Wøien, H. Flaatten, K. Sunde, J. J. Cáceres Agra, J. L. Santana Cabrera, J. D. Martín Santana, L. Melián Alzola, H. Rodríguez Pérez, T. Castro Pires, H. Calderón, A. Pereira, S. Castro, C. Granja, I. Norkiene, I. Urbanaviciute, G. Kezyte, D. Ringaitiene, T. Jovaisa, G. Vogel, U. B. Johansson, A. Sandgren, C. Svensen, E. Joelsson-Alm, M. A. Leite, L. D. Murbach, E. F. Osaku, C. R. L. M. Costa, M. Pelenz, N. M. Neitzke, M. M. Moraes, J. L. Jaskowiak, M. M. M. Silva, R. S. Zaponi, L. R. L. Abentroth, S. M. Ogasawara, A. C. Jorge, P. A. D. Duarte, J. Barreto, S. T. Duarte, S. Taba, D. Miglioranza, D. P. Gund, C. F. Lordani, H. Vollmer, M. Gager, C. Waldmann, A. T. Mazzeo, R. Tesio, C. Filippini, M. E. Vallero, C. Giolitti, S. Caccia, M. Medugno, T. Tenaglia, R. Rosato, I. Mastromauro, L. Brazzi, P. P. Terragni, R. Urbino, V. Fanelli, V. M. Ranieri, L. Mascia, J. Ballantyne, L. Paton, P. Perez-Teran, O. Roca, J. C. Ruiz-Rodriguez, A. Zapatero, J. Serra, S. Bianzina, P. Cornara, G. Rodi, G. Tavazzi, M. Pozzi, G. A. Iotti, F. Mojoli, A. Braschi, A. Vishnu, D. Buche, R. Pande, D. L. J. Moolenaar, F. Bakhshi-Raiez, D. A. Dongelmans, N. F. de Keizer, D. W. de Lange, I. Fuentes Fernández, D. Martínez Baño, J. L. Buendía Moreno, R. Jara Rubio, J. Scott, D. Phelan, D. Morely, J. O’Flynn, P. Stapleton, M. Lynch, B. Marsh, E. Carton, C. O’Loughlin, K. C. Cheng, M. I. Sung, M. O. Elghonemi, M. H. Saleh, T. S. Meyhoff, M. Krag, P. B. Hjortrup, M. H. Møller, T. Öhman, T. Sigmundsson, E. Redondo, M. Hallbäck, F. Suarez-Sipmann, H. Björne, C. Hällsjö Sander, KARISMA, D. Chiumello, C. Chiurazzi, M. Brioni, I. Algieri, M. Guanziroli, G. Vergani, T. Tonetti, I. Tomic, A. Colombo, F. Crimella, E. Carlesso, V. Gasparovic, R. El-Sherif, M. Abd Al-Basser, A. Raafat, A. El-Sherif, L. R. A. Schouten, O. L. Cremer, D. S. Y. Ong, G. Amoruso, G. Cinnella, L. D. J. Bos, P. Schmidle, M. Findeisen, P. Hoppmann, J. Jaitner, F. Brettner, T. Lahmer, EXODUS-investigators, G. Rajagopalan, V. Bansal, R. Frank, R. Hinds, J. Levitt, United States Critical Illness and Injury Trials Group/LIPS-B investigators, S. Siddiqui, SICM NICER Group, J. P. Gilbert, K. Sim, C. H. Wang, I. J. Li, W. R. Tang, P. Persona, A. De Cassai, M. Franco, A. Goffi, B. Llorente Ruiz, J. Lujan Varas, R. Molina Montero, C. Pintado Delgado, O. Navarrete, M. Vazquez Mezquita, E. Alonso Peces, M. A. M. Nakamura, L. A. Hajjar, F. R. B. G. Galas, T. A. Ortiz, M. B. P. Amato, L. Bitker, N. Costes, D. Le Bars, F. Lavenne, D. Mojgan, J. C. Richard, D. Massari, M. Gotti, P. Cadringher, A. Zerman, M. Türkoğlu, G. Arık, F. Yıldırım, Z. Güllü, I. Kara, N. Boyacı, B. Basarık Aydoğan, Ü. Gaygısız, K. Gönderen, G. Aygencel, M. Aydoğdu, Z. Ülger, G. Gürsel, J. Riera, C. Maldonado Toral, C. Mazo, M. Martínez, J. Baldirà, L. Lagunes, A. Roman, M. Deu, J. Rello, D. J. Levine, R. M. Mohus, Å. Askim, J. Paulsen, A. Mehl, A. T. Dewan, J. K. Damås, E. Solligård, B. O. Åsvold, Mid-Norway Sepsis Research Center, A. DeWan, O. Aktepe, A. Kara, H. Yeter, A. Topeli, M. Norrenberg, M. Devroey, H. Khader, J. C. Preiser, Z. Tang, C. Qiu, L. Tong, C. Cai, O. Apostolopoulou, J. Y. Moon, M. R. Park, I. S. Kwon, G. R. Chon, J. Y. Ahn, S. J. Kwon, Y. J. Chang, J. Y. Lee, S. Y. Yoon, J. W. Lee, The Korean Chungcheong Critical Care Research Group, M. Kostalas, J. Mckinlay, G. Kooner, G. Dudas, A. Horton, C. Kerr, N. Karanjia, B. Creagh-Brown, N. D. Altintas, S. Izdes, O. Keremoglu, A. Alkan, S. Neselioglu, O. Erel, N. Tardif, T. Gustafsson, K. N. MacEachern, M. Traille, I. Bromberg, S. E. Lapinsky, M. J. Moore, J. L. García-Garmendia, F. Villarrasa-Clemente, F. Maroto-Monserrat, O. Rufo-Tejeiro, V. Jorge-Amigo, M. Sánchez-Santamaría, C. Colón-Pallarés, A. Barrero-Almodóvar, S. Gallego-Lara, C. T. Anthon, R. B. Müller, N. Haase, K. Møller, J. Wetterslev, M. Nakanishi, A. Kuriyama, T. Fukuoka, M. A. Abd el Halim, M. H. Elsaid hafez, A. M. Moktar, H. M. Elazizy, K. Abdel Hakim, M. Elbahr, T. Mahmoud, E. Khalil, W. Casey, S. H. Zaky, A. Rizk, R. Ahmed, G. A. Ospina-Tascón, A. F. Garcia Marin, G. J. Echeverry, W. F. Bermudez, H. J. Madriñan-Navia, J. D. Valencia, E. Quiñonez, A. Marulanda, C. A. Arango-Dávila, A. Bruhn, D. De Backer, D. Orbegozo Cortes, F. Su, J. L. Vincent, L. Tullo, L. Mirabella, P. Di Molfetta, M. Dambrosio, C. Villavicencio Lujan, J. Leache irigoyen, M. Cartanya ferré, R. Carbonell García, M. Ahmed, M. El Ayashi, E. Ayman, M. Salem, S. Fathy, A. Zaghlol, M. F. Aguilar Arzapalo, Å. Valsø, T. Rustøen, I. Schou-Bredal, L. Skogstad, K. Tøien, C. Padilla, Y. Palmeiro, W. Egbaria, R. Kigli, B. Maertens, K. Blot, S. Blot, E. Santana-Santos, E. R. dos Santos, R. E. D. L. Ferretti-Rebustini, R. D. C. C. D. O. dos Santos, R. G. S. Verardino, L. A. Bortolotto, A. M. Doyle, I. Naldrett, J. Tillman, S. Price, P. Pearson, J. Greaves, D. Goodall, A. Berry, A. Richardson, G. O. Odundo, P. Omengo, P. Obonyo, N. M. Chanzu, R. Kleinpell, S. J. Sarris, P. Nedved, M. Heitschmidt, H. Ben-Ghezala, S. Snouda, S. Djobbi, N. K. J. Adhikari, D. Leasa, D. Fergusson, D. A. Mckim, J. Weblin, D. McWilliams, F. Doesburg, F. Cnossen, W. Dieperink, W. Bult, M. W. N. Nijsten, G. A. Galvez-Blanco, C. I. Olvera Guzman, J. Santos Stroud, R. Thomson, M. Llaurado-Serra, A. Lobo-Civico, M. Pi-Guerrero, I. Blanco-Sanchez, A. Piñol-Tena, C. Paños-Espinosa, Y. Alabart-Segura, B. Coloma-Gomez, A. Fernandez-Blanco, F. Braga-Dias, M. Treso-Geira, A. Valeiras-Valero, L. Martinez-Reyes, A. Sandiumenge, M. F. Jimenez-Herrera, CAPCRI Study, R. Prada, P. Juárez, R. Argandoña, J. J. Díaz, C. Sánchez Ramirez, P. Saavedra, S. Ruiz Santana, O. Obukhova, S. Kashiya, I. A. Kurmukov, A. M. Pronina, P. Simeone, L. Puybasset, G. Auzias, O. Coulon, B. Lesimple, G. Torkomian, A. Bartkowska-Sniatkowska, O. Szerkus, D. Siluk, J. Bartkowiak-Wieczorek, J. Rosada-Kurasinska, J. Warzybok, R. Kaliszan, C. Hernandez Caballero, S. Roberts, G. Isgro, D. Hall, G. Guillaume, O. Passouant, F. Dumas, W. Bougouin, B. Champigneulle, M. Arnaout, J. Chelly, J. D. Chiche, O. Varenne, J. P. Mira, E. Marijon, A. Cariou, M. Beerepoot, H. R. Touw, K. Parlevliet, C. Boer, P. W. Elbers, Á. J. Roldán Reina, Y. Corcia Palomo, R. Martín Bermúdez, L. Martín Villén, I. Palacios García, J. R. Naranjo Izurieta, J. B. Pérez Bernal, F. J. Jiménez Jiménez, Cardiac Arrest Group HUVR, F. Cota-Delgado, T. Kaneko, H. Tanaka, M. Kamikawa, R. Karashima, S. Iwashita, H. Irie, S. Kasaoka, O. Arola, R. Laitio, A. Saraste, J. Airaksinen, M. Pietilä, M. Hynninen, J. Wennervirta, M. Bäcklund, E. Ylikoski, P. Silvasti, E. Nukarinen, J. Grönlund, V. P. Harjola, J. Niiranen, K. Korpi, M. Varpula, R. O. Roine, T. Laitio, for the Xe-HYPOTHECA study group, S. Salah, B. G. Hassen, A. Mohamed Fehmi, Y. C. Hsu, J. Barea-Mendoza, C. García-Fuentes, M. Castillo-Jaramillo, H. Dominguez-Aguado, R. Viejo-Moreno, L. Terceros-Almanza, S. Bermejo Aznárez, C. Mudarra-Reche, W. Xu, M. Chico-Fernández, J. C. Montejo-González, K. Crewdson, M. Thomas, M. Merghani, L. Fenner, P. Morgan, D. Lockey, E. J. van Lieshout, B. Oomen, J. M. Binnekade, R. J. de Haan, N. P. Juffermans, M. B. Vroom, R. Algarte, L. Martínez, B. Sánchez, I. Romero, F. Martínez, S. Quintana, J. Trenado, O. Sheikh, D. Pogson, R. Clinton, F. Riccio, A. Arthur, L. Young, A. Sinclair, D. Markopoulou, K. Venetsanou, L. Filippou, E. Salla, S. Stratouli, I. Alamanos, A. H. Guirgis, R. Gutiérrez Rodriguez, M. J. Furones Lorente, I. Macias Guarasa, A. Ukere, S. Meisner, G. Greiwe, B. Opitz, D. Benten, B. Nashan, L. Fischer, C. J. C. Trepte, C. R. Behem, B. Ana, A. Vazir, D. Gibson, M. R. Hadavi, M. Riahi alam, M. R. Sasani, N. Parenti, F. Agrusta, C. Palazzi, B. Pifferi, R. Sganzerla, F. Tagliazucchi, A. Luciani, M. Möller, J. Müller-Engelmann, G. Montag, P. Adams, C. Lange, J. Neuzner, R. Gradaus, K. H. Wodack, F. Thürk, A. D. Waldmann, M. F. Grässler, S. Nishimoto, S. H. Böhm, E. Kaniusas, C. J. Trepte, M. Wallin, F. Suarez Sipman, A. Oldner, L. Colinas, R. Vicho, M. Serna, R. Cuena, A. Canabal, ECOCRITIC group, M. Etman, M. El Bahr, A. El Sakka, A. Arali, O. Bond, P. De Santis, E. Iesu, F. Franchi, S. Scolletta, F. S. Taccone, Z. Marutyan, L. Hamidova, A. Shakotko, V. Movsisyan, I. Uysupova, A. Evdokimov, S. Petrikov, F. J. Redondo Calvo, N. Bejarano, V. Baladron, R. Villazala, J. Redondo, D. Padilla, P. Villarejo, C. Gomez-Gonzalez, S. Mas-Font, A. Puppo-Moreno, M. Herrera-Gutierrez, M. Garcia-Garcia, S. Aldunate-Calvo, NEFROCON Investigators, E. P. Plata-Menchaca, X. L. Pérez-Fernández, M. Estruch, A. Betbese-Roig, P. Cárdenas Campos, M. Rojas Lora, N. D. Toapanta Gaibor, R. S. Contreras Medina, V. D. Gumucio Sanguino, E. J. Casanova, J. Sabater Riera, SIRAKI group, K. Kritmetapak, S. Peerapornratana, P. Kittiskulnam, T. Dissayabutra, P. Susantithapong, K. Praditpornsilpa, K. Tungsanga, S. Eiam-Ong, T. Winkelmann, T. Busch, J. Meixensberger, S. Bercker, E. M. Flores Cabeza, M. Sánchez Sánchez, N. Cáceres Giménez, C. Gutierrez Melón, E. Herrero de Lucas, P. Millán Estañ, M. Hernández Bernal, A. Garcia de Lorenzo y Mateos, P. A. C. Specht, M. Balik, M. Zakharchenko, F. Los, H. Brodska, C. de Tymowski, P. Augustin, M. Desmard, P. Montravers, S. N. Stapel, R. de Boer, H. M. Oudemans, A. Hollinger, T. Schweingruber, F. Jockers, M. Dickenmann, M. Siegemund, Clinical Intensive Care Research Basel, N. Runciman, L. Alban, C. Turrini, T. Sasso, T. Langer, P. Taccone, C. Marenghi, G. Grasselli, P. Wibart, T. Reginault, M. Garcia, B. Barbrel, A. Benard, C. Bader, F. Vargas, H. N. Bui, G. Hilbert, J. M. Serrano Simón, P. Carmona Sánchez, F. Ruiz Ferrón, M. García de Acilu, J. Marin, V. Antonia, L. Ruano, M. Monica, G. Hong, D. H. Kim, Y. S. Kim, J. S. Park, Y. K. Jee, Z. Yu xiang, W. Jia-xing, W. Xiao dan, N. Wen long, W. Yu, Z. Yan, X. Cheng, T. Kobayashi, Y. Onodera, R. Akimoto, A. Sugiura, H. Suzuki, M. Iwabuchi, M. Nakane, K. Kawamae, P. Carmona Sanchez, M. D. Bautista Rodriguez, M. Rodriguez Delgado, V. Martínez de Pinillos Sánchez, A. Mula Gómez, P. Beuret, C. Fortes, M. Lauer, M. Reboul, J. C. Chakarian, X. Fabre, B. Philippon-Jouve, S. Devillez, M. Clerc, N. Rittayamai, M. Sklar, M. Dres, M. Rauseo, C. Campbell, B. West, D. E. Tullis, M. Okada, N. Ahmad, M. Wood, A. Glossop, J. Higuera Lucas, A. Blandino Ortiz, D. Cabestrero Alonso, R. De Pablo Sánchez, L. Rey González, R. Costa, G. Spinazzola, A. Pizza, G. Ferrone, M. Rossi, G. Conti, H. Ribeiro, J. Alves, M. Sousa, P. Reis, C. S. Socolovsky, R. P. Cauley, J. E. Frankel, A. L. Beam, K. O. Olaniran, F. K. Gibbons, K. B. Christopher, J. Pennington, P. Zolfaghari, H. S. King, H. H. Y. Kong, H. P. Shum, W. W. Yan, C. Kaymak, N. Okumus, A. Sari, B. Erdogdu, S. Aksun, H. Basar, A. Ozcan, N. Ozcan, D. Oztuna, J. A. Malmgren, S. Lundin, K. Torén, M. Eckerström, A. Wallin, A. C. Waldenström, for the Section on Ethics of the ESICM, F. C. Riccio, A. C. P. Antonio, A. F. Leivas, F. Kenji, E. James, S. Jonnada, C. S. Gerrard, N. Jones, J. D. Salciccioli, D. C. Marshall, M. Komorowski, A. Hartley, M. C. Sykes, R. Goodson, J. Shalhoub, J. R. Fernández Villanueva, R. Fernández Garda, A. M. López Lago, E. Rodríguez Ruiz, R. Hernández Vaquero, C. Galbán Rodríguez, E. Varo Pérez, C. Hilasque, I. Oliva, G. Sirgo, M. C. Martin, M. Olona, M. C. Gilavert, M. Bodí, C. Ebm, G. Aggarwal, S. Huddart, N. Quiney, S. M. Fernandes, J. Santos Silva, J. Gouveia, D. Silva, R. Marques, H. Bento, A. Alvarez, Z. Costa Silva, D. Díaz Diaz, M. Villanova Martínez, E. Palencia Herrejon, A. Martinez de la Gandara, G. Gonzalo, M. A. Lopez, P. Ruíz de Gopegui Miguelena, C. I. Bernal Matilla, P. Sánchez Chueca, M. D. C. Rodríguez Longares, R. Ramos Abril, A. L. Ruíz Aguilar, R. Garrido López de Murillas, R. Fernández Fernández, P. Morales Laborías, M. A. Díaz Castellanos, M. E. Morales Laborías, J. Park, S. Woo, T. West, E. Powell, A. Rimmer, C. Orford, J. Williams, P. Ruiz de Gopegui Miguelena, R. S. Bourne, R. Shulman, M. Tomlin, G. H. Mills, M. Borthwick, W. Berry, D. García Huertas, F. Manzano, F. Villagrán-Ramírez, A. Ruiz-Perea, C. Rodríguez-Mejías, F. Santiago-Ruiz, M. Colmenero-Ruiz, C. König, B. Matt, A. Kortgen, C. S. Hartog, A. Wong, C. Balan, G. Barker, S. Tachaboon, J. Paratz, G. Kayambu, R. Boots, R. Vlasenko, E. Gromova, S. Loginov, M. Kiselevskiy, Y. Dolgikova, K. B. Tang, C. M. Chau, K. N. Lam, E. Gil, G. Y. Suh, C. M. Park, C. R. Chung, C. H. Lai, Y. J. Cheng, V. Colella, N. Zarrillo, M. D’Amico, F. Forfori, B. Pezza, T. Laddomada, V. Beltramelli, M. L. Pizzaballa, A. Doronzio, B. Balicco, D. Kiers, W. van der Heijden, J. Gerretsen, Q. de Mast, S. el Messaoudi, G. Rongen, M. Gomes, N. P. Riksen, Y. Kashiwagi, K. Hayashi, Y. Inagaki, S. Fujita, A. Blet, M. Sadoune, J. Lemarié, N. Bihry, R. Bern, E. Polidano, R. Merval, J. M. Launay, B. Lévy, J. L. Samuel, J. Hartmann, S. Harm, and V. Weber

Subjects
Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Published
2016
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14. Climatically driven changes in population composition and offspring sex‐morph ratio in a polymorphic species

Author

E. M. Tuttle, A. S. Grunst, M. L. Grunst, M. L. Korody, A. M. Betuel, M. Barcelo‐Serra, G. Bierly, and R. A. Gonser

Subjects
El Niño, genetic polymorphism, morph ratios, population composition, sex ratios, teleconnection patterns, Ecology, QH540-549.5
Abstract

Abstract Females from polymorphic species could theoretically benefit by adjusting offspring morph composition, since morphs often differ in ecological and behavioral traits, and may be differentially susceptible to environmental conditions. Although offspring sex ratio adjustments have been increasingly supported, whether, and in which contexts, genetically determined morph ratios are adjusted has not been established. We used a long‐term dataset to examine whether broad‐scale climatic patterns characterized by teleconnection indices, population composition, and other environmental factors affect offspring sex‐morph ratios in the white‐throated sparrow (Zonotrichia albicollis), a species with chromosomal morph determination. We predicted that females might overproduce the underrepresented sex or morph, since pairing is disassortative by morph, and might also produce more white morph male offspring given favorable climatic conditions, because white males (WMs) are large, promiscuous, and expensive to produce. The proportion of WM‐by‐tan female breeding pairs and recruitment of WMs declined following winters with high Pacific North American teleconnection indices, and females of both morphs produced more WM offspring after these relatively cold winters. These winters and the following springs were also associated with low Southern Oscillation indices, indicating El Niño. Females of both morphs also produced fewer males late in asynchronously hatching broods. Adjustment of brood composition in response to climatically mediated changes in population composition could stabilize the white‐throated sparrow's disassortative breeding system and genetic polymorphism.

Published
2017
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15. Delphi survey on the application of advanced practice nursing competencies: Strong points and unfinished business in cancer care

Author

M. Antònia Serra‐Barril, Llúcia Benito‐Aracil, Margarida Pla‐Consuegra, and Tarsila Ferro‐García

Subjects
Advanced Practice Nursing, Leadership, Consensus, Delphi Technique, Leadership and Management, Evidence-Based Practice, Neoplasms, Humans, Clinical Competence
Abstract

This study assessed the application of advanced practice nursing competencies in cancer care to identify obstacles to their full implementation.Internationally, the implementation of advanced practice nursing roles depends on the context and environment, which shape the definition, scope and competencies associated with these roles.Nurses participated in two rounds of an online Delphi survey about the competencies of advanced practice oncology nurses. The threshold for expert consensus was set at 75%.Eleven competency domains were proposed; all yielded consensus of over 75%. However, for 57.8% of the specific competencies proposed in round 1 and for 62.2% in round 2, there was no consensus on which were applied in practice. There was more agreement on the competencies applied in the domains of direct clinical practice, consultation and collaboration and interprofessional relations than in dimensions such as health care promotion, quality improvement, evidence-based practice and research. Barriers related to unimplemented competencies were identified.The competencies applied in advanced practice nursing reflect incomplete development of these roles. Domains related to direct clinical practice, consultation and collaboration and interprofessional relations are relatively well developed, whereas those related to leadership, research, evidence-based practice and quality improvement are not. The identified barriers hindering implementation of some competencies can inform strategies to develop this role in cancer care.Hospital administrators and nurse managers should reflect and be mindful of the development of advanced practice nurse (APN) competencies along with the challenges associated with implementing advanced practice roles.

Published
2022

17. Quantitative firing transformations of a triaxial ceramic by X-ray diffraction methods

Author

M. S. Conconi, M. R. Gauna, M. F. Serra, G. Suarez, E. F. Aglietti, and N. M. Rendtorff

Subjects
cerâmicas triaxiais, DRX-Rietveld, processamento, caracterização, Engineering (General). Civil engineering (General), TA1-2040
Abstract

The firing transformations of traditional (clay based) ceramics are of technological and archeological interest, and are usually reported qualitatively or semiquantitatively. These kinds of systems present an important complexity, especially for X-ray diffraction techniques, due to the presence of fully crystalline, low crystalline and amorphous phases. In this article we present the results of a qualitative and quantitative X-ray diffraction Rietveld analysis of the fully crystalline (kaolinite, quartz, cristobalite, feldspars and/or mullite), the low crystalline (metakaolinite and/or spinel type pre-mullite) and glassy phases evolution of a triaxial (clay-quartz-feldspar) ceramic fired in a wide temperature range between 900 and 1300 ºC. The employed methodology to determine low crystalline and glassy phase abundances is based in a combination of the internal standard method and the use of a nanocrystalline model where the long-range order is lost, respectively. A preliminary sintering characterization was carried out by contraction, density and porosity evolution with the firing temperature. Simultaneous thermo-gravimetric and differential thermal analysis was carried out to elucidate the actual temperature at which the chemical changes occur. Finally, the quantitative analysis based on the Rietveld refinement of the X-ray diffraction patterns was performed. The kaolinite decomposition into metakaolinite was determined quantitatively; the intermediate (980 ºC) spinel type alumino-silicate formation was also quantified; the incongruent fusion of the potash feldspar was observed and quantified together with the final mullitization and the amorphous (glassy) phase formation.The methodology used to analyze the X-ray diffraction patterns proved to be suitable to evaluate quantitatively the thermal transformations that occur in a complex system like the triaxial ceramics. The evaluated phases can be easily correlated with the processing variables and materials properties. These correlations can be employed for materials characterization, design and processing control.

Published
2014
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18. Rapid prototyping of a complex model for the manufacture of plaster molds for slip casting ceramic

Author

D. P. C. Velazco, E. F. Sancet, F. Urbaneja, M. Piccico, M. F. Serra, M. F. Acebedo, G. Suárez, and N. M. Rendtorff

Subjects
modelagem digital, impressão 3D, cerâmicas tradicionais, Engineering (General). Civil engineering (General), TA1-2040
Abstract

Computer assisted designing (CAD) is well known for several decades and employed for ceramic manufacturing almost since the beginning, but usually employed in the first part of the projectual ideation processes, neither in the prototyping nor in the manufacturing stages. The rapid prototyping machines, also known as 3D printers, have the capacity to produce in a few hours real pieces using plastic materials of high resistance, with great precision and similarity with respect to the original, based on unprecedented digital models produced by means of modeling with specific design software or from the digitalization of existing parts using the so-called 3D scanners. The main objective of the work is to develop the methodology used in the entire process of building a part in ceramics from the interrelationship between traditional techniques and new technologies for the manufacture of prototypes. And to take advantage of the benefits that allow us this new reproduction technology. The experience was based on the generation of a complex piece, in digital format, which served as the model. A regular 15 cm icosahedron presented features complex enough not to advise the production of the model by means of the traditional techniques of ceramics (manual or mechanical). From this digital model, a plaster mold was made in the traditional way in order to slip cast clay based slurries, freely dried in air and fired and glazed in the traditional way. This experience has shown the working hypothesis and opens up the possibility of new lines of work to academic and technological levels that will be explored in the near future. This technology provides a wide range of options to address the formal aspect of a part to be performed for the field of design, architecture, industrial design, the traditional pottery, ceramic art, etc., which allow you to amplify the formal possibilities, save time and therefore costs when drafting the necessary and appropriate matrixes to each requirement.

Published
2014
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19. Volcanic and environmental impacts on subfossil chironomids from Northern Patagonia (Argentina) over the last 700 years

Author

Gustavo Villarosa, M. Noel Serra, and Julieta Massaferro

Subjects
0106 biological sciences, geography, Subfossil, geography.geographical_feature_category, Ecology, 010604 marine biology & hydrobiology, Climate change, Aquatic Science, 010603 evolutionary biology, 01 natural sciences, Volcano, Environmental science, Glacial period, Physical geography, Tephra, Tephrochronology, Southern Hemisphere, Water Science and Technology, Volcanic ash
Abstract

Southern South America, especially Patagonia, presents numerous glacial lakes holding proxies of past environmental and climate changes. This is useful to reconstruct past environmental changes, key for understanding Southern Hemisphere variability and the present. Our aim was to identify the volcanic and environmental impact that occurred during the last 700 year in Northern Patagonia (Argentina) using subfossil chironomids, organic matter content, and tephrochronology from short sediment cores of two lakes located between Los Alerces National Park and Esquel city. Both lakes have similar watershed characteristics and were affected by the same volcanic events, making them an excellent tool for study environmental changes. Although changes in chironomid assemblages were subtle along both cores, enviromental variations and faunal responses to volcanic ash (tephra) could be inferred. In the last 50 years, an increase of organic matter, chironomids typical of productive environments, and the presence of macrophytes, point towards an increase in lake productivity. Probably linked to the establishment of Esquel city and fisheries starting in 1966 AD. Four tephra were recorded along cores affecting chironomid abundance differently, showing that the effects of volcanic events are not unique onefold but are related to the characteristics of the ash, the effect of wind, rain, and/or macrophytes.

Published
2021
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20. Therapeutic yoga reduces pro-tumorigenic cytokines in cancer survivors

Author

Darpan I. Patel, G. J. Almeida, N. T. Darby, M. C. Serra, T. Calderon, A. Lapetoda, B. Gutierrez, A. G. Ramirez, and D. C. Hughes

Subjects
Male, Adult, Inflammation, Adolescent, Tumor Necrosis Factor-alpha, Yoga, Middle Aged, Interleukin 1 Receptor Antagonist Protein, Meditation, C-Reactive Protein, Oncology, Cancer Survivors, Humans, Cytokines, Female, Interleukin-4, Neoplasm Recurrence, Local, Aged
Abstract

Chronic inflammation can remain many years after the completion of cancer treatment and is associated with cancer recurrence. The purpose of this study was to examine how a 16-week therapeutic yoga program (TYP) modulates the cytokine profile in heterogeneous cancer survivors.Eligible participants were 18 years of age or older and clinically diagnosed with cancer. Consenting participants were asked to attend three, 75-min sessions weekly of TYP with meditation. Seventeen patients provided blood samples at baseline and end of study. Eight cytokines (interferon (IFN)-γ; interleukin (IL)-1b, IL-1ra, IL-4, IL-6, IL-8, IL-10; and tumor necrosis factor (TNF)-α), three receptors (sIL-6R, sTNFRI, sTNFRII), and C-reactive protein (CRP) were quantified.Patients were 59.6 ± 7.3 years old; over half (56%) were overweight or obese BMI ≥ 25 kg/mTYP led to significant reduction in circulating cytokines associated with chronic inflammation in a heterogeneous sample of cancer survivors.

Published
2022

22. Improving the quality of life an empowerment of our patients with ischemic heart disease

Author

B Gonzalez Batista, F Marti Bertomeu, A Clemente Prat, P Corzan Melgosa, M Esclusa Serra, N Santaularia Capdevila, L Pintado Pallares, and G Vazquez Oliva

Subjects
Advanced and Specialized Nursing, Medical–Surgical Nursing, Cardiology and Cardiovascular Medicine
Abstract

Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): Fundació Althaia It is proved that nursing interventions in chronic coronary heart illnesses decrease mortality and risk of a new coronary event. This is achieved through the development and performance of a personalized educational plan, focused on health promotion, aimed at modifying or enhancing a heart-healthy lifestyle and facilitating strategies to promote patient's empowerment, helping them assume certain responsibility in their own heart-healthy. Always based on humanized and empathetic care. This individual attention is reinforced with a "Health School" which is a group of talks addressed to patients and their close family members. Since 2019 we organizer two to healthy walks a year. Once the program is completed are referred to the Primary Care nursing. Objectives Improving the knowledge's level of patients with regards to their illness and its treatment. The keys consist in designing easy strategies for an optimum self-control of the illness. Evaluate the acquired knowledge and recording level of satisfaction with the program. Methodology A descriptive and retrospective study of patients with ischemic heart disease the for 5 years, from 2015 to 2020. After the hospital discharge, an outpatient nursing follow-up is performed on a 1, 3 and 6 months basis finalizing whit a group talk a kind of "School of health", carried out 3 times a year in 3 educational sessions. Results Among 960 patients monitored: 852 who successfully completed, 97 abandoned the program before having completed it and 11 who unfortunately died. The variables studied in the educational plan are: Identifies cardiovascular risk factors and knows how to act tochange them (82.5%) Recognizes signs and symptoms of chest pain and how to act (90.9%) Recognizes their responsibility for monitoring of the prescribed treatment (91.2%). In relation to the "School of health" 334 patients attended 156 companions, of the topics covered: the most important was the psychological / emotional aspect followed by control of risk factors and exercise, the information on the pathology and finally diet and sexuality. Innovative contribution to policy, practice and/or research The nursing interventions carried out with Educational Program hare proved on patients knowledge improvement and a higher adherence to treatment as well as a major self control of risk factors. Patients and their families report a high level of satisfaction with the program. Under our opinion all this will have a positive impact in the future an impact in the future improving the quality of life of patients and their closest families, reducing the possibilities of new coronary events decreasing as well health care costs for the society. It will more over guaranties a good continuity between specialized and primary care nursing.

Published
2022
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23. Firing transformations of an argentinean calcareous commercial clay

Author

M. F. Serra, M.S. Conconi, G. Suarez, E. F. Agietti, and N. M. Rendtorff

Subjects
processamento de cerâmica de silicato, estrutura, difração de raios X, Engineering (General). Civil engineering (General), TA1-2040
Abstract

Mineralogical transformations caused by firing are usually studied by XRD methods only semi-quantitatively. In this work the original mineral disappearance and the neo-mineralization were evaluated quantitatively. Furthermore an indirect non crystalline phase quantification was performed under 1100 ºC was also carried out using the quartz content as internal standard. This study specifically discusses the behavior of an Argentinean white calcareous earthenware commercial when subjected to traditional ceramic firing, besides the technological importance of this particular material, it acts as a model for other clay based ceramic materials. Materials were subjected to thermal treatments between 700 ºC and 1100 ºC. A preliminary sintering characterization was carried out by contraction and porosity evolution. Simultaneous thermogravimetric and differential thermal analysis (TG-DTA) was carried out to elucidate the actual temperature at which the chemical changes occur. Finally, a quantitative analysis based on the Rietveld refinement of the X-ray diffraction patterns was performed to characterize the crystalline phases present in both the clay and in the materials obtained after different thermal treatments. The actual chemical reactions are proposed. The phases identified after firing at traditional working temperature (1040 ºC) are quartz, plagioclase, and the Spinel type alumino-silicate, accompanied by the non-diffracting un-reacted metakaolin and some amount of amorphous glassy phase. At intermediate temperatures (900 ºC) the presence of gehlenite was also detected. The carbonates (calcite and dolomite) presence and decomposition were also evaluated and demonstrated to determine the sintering characteristics of this material.

Published
2013
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24. A multidisciplinary approach to study the functional properties of neuron-like cell models constituting a living bio-hybrid system: SH-SY5Y cells adhering to PANI substrate

Author

S. Caponi, S. Mattana, M. Ricci, K. Sagini, L. J. Juarez-Hernandez, A. M. Jimenez-Garduño, N. Cornella, L. Pasquardini, L. Urbanelli, P. Sassi, A. Morresi, C. Emiliani, D. Fioretto, M. Dalla Serra, C. Pederzolli, S. Iannotta, P. Macchi, and C. Musio

Subjects
Physics, QC1-999
Abstract

A living bio-hybrid system has been successfully implemented. It is constituted by neuroblastic cells, the SH-SY5Y human neuroblastoma cells, adhering to a poly-anyline (PANI) a semiconductor polymer with memristive properties. By a multidisciplinary approach, the biocompatibility of the substrate has been analyzed and the functionality of the adhering cells has been investigated. We found that the PANI films can support the cell adhesion. Moreover, the SH-SY5Y cells were successfully differentiated into neuron-like cells for in vitro applications demonstrating that PANI can also promote cell differentiation. In order to deeply characterize the modifications of the bio-functionality induced by the cell-substrate interaction, the functional properties of the cells have been characterized by electrophysiology and Raman spectroscopy. Our results confirm that the PANI films do not strongly affect the general properties of the cells, ensuring their viability without toxic effects on their physiology. Ascribed to the adhesion process, however, a slight increase of the markers of the cell suffering has been evidenced by Raman spectroscopy and accordingly the electrophysiology shows a reduction at positive stimulations in the cells excitability.

Published
2016
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25. Training of health referents at child care centers. Experience in Argentina

Author

M Elina, Serra and Rose M, Soria

Subjects
Eating, Pediatrics, Perinatology and Child Health, Argentina, Humans, Child Day Care Centers, Child Care, Child
Abstract

An adequate child care helps to mitigate the effects of social adversity. Health prevention is a part of it. This is an innovative training program for health referents in child care centers that cater to vulnerable populations in Buenos Aires, Argentina. It consisted in training child care center staff, followed by the implementation, over 4 months, of an improvement plan developed by each participant in their center, with ongoing advisory support. In total, 26 participants from 19 centers completed the program. In total, 35 out of 49 goals proposed in the plans were achieved, including the certification in cardiopulmonary resuscitation, staff and family training, development of center policies, and improved resource management. Preventive care offered in child care centers may be improved via a simple and inexpensive intervention, including in unfavorable conditions.El cuidado infantil de buena calidad atenúa los efectos de la adversidad social. La prevención en salud es parte de él. Se presenta un programa innovador de formación de referentes de salud en centros de cuidado infantil que atienden a poblaciones vulnerables en Buenos Aires, Argentina. Este consistió en una capacitación para personal de centros de cuidado infantil, seguido de la implementación, durante 4meses, de un plan de mejoras elaborado por cada participante para su centro, con apoyo de consultoría permanente. Veintiséis participantes de 19centros completaron el programa. Se alcanzaron 35 de 49 objetivos planteados en los planes, incluida la certificación en reanimación cardiopulmonar, la capacitación del personal y las familias, el desarrollo de políticas del centro y la mejora de la gestión de recursos. Es posible mejorar los cuidados preventivos en los centros de cuidado infantil mediante una intervención sencilla y de bajo costo, incluso en condiciones desfavorables.

Published
2022
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29. Circumareolar Mastopexy with Multiple Glandular Plications for Symmetry of the Contra-Lateral Breast, in Patients Undergoing Breast Reconstruction with Prosthesis. Experience on 50 Cases

Author

M. P. Serra, P. Longhi, and E. Robotti

Subjects
breast reconstruction with prosthesis, symmetrization, mastopexy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

4 years experience on 50 cases using the Elliott’s technique for symmetrization of the contra-lateral breast in patients undergoing breast reconstruction with an anatomical prosthesis is presented in this paper. The Elliott’s technique with its double superior and horizontal plication is a suitable and long-lasting procedure for patients with small-moderate ptotic breast and elastic skin, who wish to have a simple procedure and an immediate result with minimal scars.

Published
2008

30. Effect of Sewerage on the Contamination of Soil with Pathogenic Leptospira in Urban Slums

Author

Federico Costa, Peter J. Diggle, Maísa Aguiar Santos, Albert I. Ko, Daiana de Oliveira, Max T. Eyre, Rafael M. R. Serra, Mitermayer G. Reis, Arnau Casanovas-Massana, Barbara Ia Xavier, Diogo César C. Santiago, Melanie Curry, Elsio A. Wunder, Anderson S. de Oliveira, Evelyn Lopes, and Fábio Neves Souza

Subjects
0303 health sciences, Veterinary medicine, 030306 microbiology, General Chemistry, Contamination, Biology, biology.organism_classification, medicine.disease, Leptospirosis, Zoonotic disease, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, 13. Climate action, Leptospira, Sewerage, medicine, Environmental Chemistry, 030212 general & internal medicine, Sanitary sewer, Pathogen, Slum
Abstract

Leptospirosis is an environmentally transmitted zoonotic disease caused by pathogenic Leptospira spp. that affects poor communities worldwide. In urban slums, leptospirosis is associated with deficient sanitary infrastructure. Yet, the role of sewerage in the reduction of the environmental contamination with pathogenic Leptospira has not been explored. Here, we conducted a survey of the pathogen in soils surrounding open and closed sewer sections in six urban slums in Brazil. We found that soils surrounding conventionally closed sewers (governmental interventions) were 3 times less likely to contain pathogenic Leptospira (inverse OR 3.44, 95% CI = 1.66-8.33; p < 0.001) and contained a 6 times lower load of the pathogen (0.82 log10 units difference, p < 0.01) when compared to their open counterparts. However, no differences were observed in community-closed sewers (poor-quality closings performed by the slum dwellers). Human fecal markers (BacHum) were positively associated with pathogenic Leptospira even in closed sewers, and rat presence was not predictive of the presence of the pathogen in soils, suggesting that site-specific rodent control may not be sufficient to reduce the environmental contamination with Leptospira. Overall, our results indicate that sewerage expansion to urban slums may help reduce the environmental contamination with the pathogen and therefore reduce the risk of human leptospirosis.

Published
2021
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31. Usefulness and Safety Evaluation of Chemotherapy Administration Device for Nurses: Experimental Study

Author

M. Antònia Serra-Barril, Marta Pamias-Nogue, Núria Zarza-Arnau, Anna Esteve-Gomez, Ana Clopes-Estela, and Paz Fernández-Ortega

Subjects
Oncology (nursing), Attitude of Health Personnel, Neoplasms, Surveys and Questionnaires, Humans, Antineoplastic Agents
Abstract

Antineoplastic drugs are considered high risk, and computerized systems favor safe administration. The objective of the study was to test the usefulness and safety of a new mobile device compared to the standard device for administering these antineoplastic treatments.This multicenter, quasi-experimental pre-post study assessed an intervention in two cancer centers in June and July 2020. Nineteen nurses participated by completing 57 questionnaires. The outcome variables were usefulness, ease of use, efficiency, safety, attitudes, and satisfaction with the new mobile device; they were measured by means of the USE questionnaire (Usefulness, Satisfaction, and Ease of use) and the Technology Attitude Survey (TAS). Professionals rated the new device higher than the standard device and showed a favorable attitude toward technology.The tested device was useful, effective, safe, and specific to the antineoplastic treatment administration process, garnering greater satisfaction among professionals than the standard.As new technologies can improve care for patients with cancer, it is essential to develop strategies to improve the experience of professionals for optimal implementation.

Published
2021

32. Effect of Sewerage on the Contamination of Soil with Pathogenic

Author

Arnau, Casanovas-Massana, Fabio, Neves Souza, Melanie, Curry, Daiana, de Oliveira, Anderson S, de Oliveira, Max T, Eyre, Diogo, Santiago, Maísa, Aguiar Santos, Rafael M R, Serra, Evelyn, Lopes, Barbara Ia, Xavier, Peter J, Diggle, Elsio A, Wunder, Mitermayer G, Reis, Albert I, Ko, and Federico, Costa

Subjects
Leptospira, Soil, Poverty Areas, Animals, Leptospirosis, Brazil, Article, Rats
Abstract

Leptospirosis is an environmentally transmitted zoonotic disease caused by pathogenic Leptospira spp. that affects poor communities worldwide. In urban slums, leptospirosis is associated with deficient sanitary infrastructure. Yet, the role of sewerage in the reduction of the environmental contamination with pathogenic Leptospira has not been explored. Here, we conducted a survey of the pathogen in soils surrounding open and closed sewer sections in six urban slums in Brazil. We found that soils surrounding conventionally closed sewers (governmental interventions) were 3 times less likely to contain pathogenic Leptospira (inverse OR 3.44, 95% CI = 1.66–8.33; p < 0.001) and contained a 6 times lower load of the pathogen (0.82 log(10) units difference, p < 0.01) when compared to their open counterparts. However, no differences were observed in community-closed sewers (poor-quality closings performed by the slum dwellers). Human fecal markers (BacHum) were positively associated with pathogenic Leptospira even in closed sewers, and rat presence was not predictive of the presence of the pathogen in soils, suggesting that site-specific rodent control may not be sufficient to reduce the environmental contamination with Leptospira. Overall, our results indicate that sewerage expansion to urban slums may help reduce the environmental contamination with the pathogen and therefore reduce the risk of human leptospirosis.

Published
2021

35. Clinical evaluation of drug-induced hepatitis Evaluación clínica de las hepatitis producidas por fármacos

Author

L. Martí, J. A. del Olmo, J. Tosca, E. Ornia, M. L. García-Torres, M. A. Serra, F. Rodríguez, P. Lluch, A. Escudero, and J. M. Rodrigo

Subjects
Hepatitis agudas, Fármacos, Epidemiología, Evolución, Características clínicas, Acute hepatitis, Drugs, Epidemiology, Evolution, Clinical characteristics, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Objective: to ascertain the epidemiological characteristics, clinical symptoms, and evolution of drug-induced hepatitis over the last 22 years. Experimental design and subjects: an observational, retrospective study between 1982 and 1993, and prospective study between 1994 and 2003. All patients in our department diagnosed with having drug-induced hepatitis were studied analyzing epidemiological (age, sex, cases per year, hospitalization) and clinical features (previous liver disease, hepatic symptoms, laboratory results), and follow-up (complete recovery or chronicity). Results: a total of 61 patients were diagnosed as having drug-induced hepatitis, 26 men and 35 women (57%), mean age 52.4 years ± 17 years, of which 72.2% were older than 40 years. A total of 43% were admitted to hospital. In 87% of cases, two or more drugs were involved, the most frequent being antituberculosis (19 cases), psychotropic (26 cases), and non-steroidal anti-inflammatory drugs (45 cases). Evolution showed that 94% of patients recovered after the withdrawal of suspected causal drugs. Conclusions: the incidence of drug-induced hepatitis is higher in patients over 40 years of age, it being more common in females. Non-steroidal anti-inflammatory, psychotropic, and anti-tuberculosis agents were the main drugs involved. Most patients made a complete recovery after withdrawal of the suspected causal drug.Objetivo: conocer las características epidemiológicas, manifestaciones clínicas y la evolución de las hepatitis producidas por fármacos en los últimos 22 años. Diseño experimental y pacientes: estudio observacional, retrospectivo entre 1982 y 1993 y prospectivo entre 1994 y 2003, donde incluimos todos los pacientes atendidos en nuestro Servicio que fueron diagnosticados de hepatitis por fármacos. Analizamos los factores epidemiológicos -edad, sexo, número de casos por año, ingresos hospitalarios-, clínicos -antecedentes de enfermedad hepática, manifestaciones clínicas-, analíticas y evolutivos -evolución a curación o cronicidad. Resultados: diagnosticamos un total de 61 pacientes con hepatitis por fármacos, 26 hombres y 35 mujeres, con edad media 52.4 ± 17 años y edades superiores a los 40 años en el 72,2%. Se produjo ingreso hospitalario en el 43% de los casos. En la mayoría de los pacientes (87%) existían dos o más fármacos siendo los antiinflamatorios no esteroideos, neurofármacos y antituberculosos, los que con más frecuencia encontramos implicados en la aparición de la enfermedad hepática. La evolución a curación se produce en el 94% de los casos. Conclusiones: las hepatitis por fármacos se presentan más frecuentemente en edades superiores a los 40 años (72%) y en mujeres (57%), siendo los fármacos más frecuentemente implicados los antiinflamatorios (45 casos), neurofármacos (26 casos) y antituberculosos (19 casos). La mayoría de los casos evolucionó a la curación.

Published
2005

36. Leishmaniose tegumentar canina em Morada das Águias (Serra da Tiririca), Maricá, Rio de Janeiro, Brasil Canine tegumentary leishmaniasis in Morada das Águias (Serra da Tiririca), Maricá, Rio de Janeiro, Brazil

Author

Cathia M. B. Serra, Cristianni A. Leal, Fabiano Figueiredo, Tânia M. Schubach, Rosemere Duarte, Cláudia M. A. Uchôa, Roger Magno M. Silva, and Maria de Fátima Madeira

Subjects
Leishmania, Leishmaniose, Cães, Zoonoses, Leishmaniasis, Dogs, Medicine, Public aspects of medicine, RA1-1270
Abstract

Descreve-se a ocorrência da leishmaniose tegumentar em cães da localidade de Morada das Águias (Serra da Tiririca), Maricá, Estado do Rio de Janeiro, Brasil. Foram avaliados 83 cães por meio de exames clínico, sorológico e parasitológico. Os soros de 11 (13,2%) animais foram reagentes à imunofluorescência indireta (IFI) e de 30 (36,1%) ao ensaio imunoenzimático (ELISA). Úlceras cutâneas e ou mucosas foram observadas em 18 (n = 83; 21,7%) dos animais. Leishmania foi isolada de 11 cães. Discute-se a ocorrência da doença e a ocupação da localidade.This is a report of canine tegumentary leishmaniasis in Morada das Águias (in the Serra da Tiririca mountain range), Maricá, Rio de Janeiro State, Brazil. A clinical, serological, and parasitological survey was performed in 83 dogs. Eleven (13.2%) were positive on indirect immunofluorescence (IIF) and 30 (36.1%) on enzyme-linked immunosorbent assay (ELISA). Ulcerated cutaneous or mucosal lesions were observed in 18 (n = 83; 21.7%) dogs. Leishmania was isolated from 11 of the animals. The disease occurrence and local occupational characteristics are discussed.

Published
2003
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37. A televisão e a visibilidade como variável estética

Author

Joaquim M. Paulo Serra

Subjects
Television, Aesthetics, Visibility, Social Sciences
Abstract

The currently somewhat generalized refusal of the "effects studies" paradigm does not imply the statement that the invention of a new medium has no "effects" over the whole culture or, even, that the "reception" of media products is a process exclusively determined by the receiver. Taking television as the specific object of analysis, we seek to demonstrate that in both processes there is a dialectics between the medium and the receiver, in such a way that neither one of them exists outside the dynamics of interaction and mutual readjustment. That dynamics, which can be described on the basis of what we, following Flusser, shall call the logic of the "black box", has an aesthesic base.

Published
2003

38. Endoscopic Band Ligation Without Resection Of Small-Sized Subepithelial Tumours: Results In Long-Term Follow Up Of A Multicentre Prospective Study (Banding-Set)

Author

Ferrán González-Huix, Raquel Ballester-Clau, S Maisterra, C Loras, L Pardo-Grau, Carlos Huertas, M Vilanova-Serra, X Andujar, P Ruiz-Ramírez, A Garcia-Sumalla, Carlos Guarner-Argente, A. Pardo, F Bas-Cutrina, JB Gornals, J Colán-Hernández, and CF Consiglieri

Subjects
medicine.medical_specialty, Long term follow up, business.industry, Medicine, Ligation, business, Prospective cohort study, Surgery, Resection
Published
2021
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39. Pepper Mild Mottle Virus Coat Protein Alone Can Elicit the Capsicum spp. L3 Gene-Mediated Resistance

Author

P. Gilardi, I. García-Luque, and M. T. Serra

Subjects
Microbiology, QR1-502, Botany, QK1-989
Abstract

The pepper mild mottle virus (PMMoV-S) (an L3 hypersensitive response [HR]-inducer strain) coat protein was expressed in Capsicum chinense (L3L3) plants with the heterologous potato virus X (PVX)-based expression system. The chimeric virus was localized in the inoculated leaves and induced the HR, thus indicating that the tobamoviral sequences that affect induction of the HR conferred by the L3 resistance gene reside in the coat protein gene. Furthermore, transient expression of the PMMoV-S coat protein in C. chinense leaves by biolistic co-bombardment with a plasmid expressing the β-glucuronidase (GUS) gene leads to the induction of cell death and expression of host defense genes. Thus, the coat protein of PMMoV-S is the elicitor of the Capsicum spp. L3 resistance gene-mediated HR.

Published
1998
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40. The Coat Protein Is Required for the Elicitation of the Capsicum L2 Gene-Mediated Resistance Against the Tobamoviruses

Author

A. de la Cruz, L. López, F. Tenllado, J. R. Díaz-Ruíz, A. I. Sanz, C. Vaquero, M. T. Serra, and I. García-Luque

Subjects
tobamovirus L2 resistance gene, Microbiology, QR1-502, Botany, QK1-989
Abstract

In Capsicum, the resistance against tobamoviruses conferred by the L2 gene is effective against all but one of the known tobamoviruses. Pepper mild mottle virus (PMMoV) is the only virus which escapes its action. To identify the viral factors affecting induction of the hypersensitive reaction (HR) mediated by the Capsicum spp. L2 resistance gene, we have constructed chimeric viral genomes between paprika mild mottle virus (PaMMV) (a virus able to induce the HR) and PMMoV. A hybrid virus with the PaMMV coat protein gene substituted in the PMMoV-S sequences was able to elicit the HR in Capsicum frutescens (L2L2) plants. These data indicate that the sequences that affect induction of the HR mediated by the L2 resistance gene reside in the coat protein gene. Furthermore, a mutant that codes for a truncated coat protein was able to systemically spread in these plants. Thus, the elicitation of the host response requires the coat protein and not the RNA.

Published
1997
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41. MODELO AVALIATIVO DE APLICAÇÃO DO LEAN SIX SIGMA EM EMPRESAS CONSTRUTORAS

Author

Lucio S. Yamamoto and Sheyla M. B. Serra

Abstract

Ainda que a indústria da construção civil tenha desenvolvido metodologias para o controle da qualidade de obras, ainda há falhas no gerenciamento da qualidade, principalmente em relação ao controle dos processos e produtos. A implantação do conjunto de práticas conhecido como Lean Six Sigma (LSS) pode proporcionar melhoria na eficiência dos processos reduzindo os desperdícios. O objetivo desta pesquisa é propor uma estrutura de avaliação de possível aplicação do LSS por meio de um questionário estruturado seguindo a formatação do ciclo DMAIC (Define, Measure, Analyse, Improve, Control). O questionário foi aplicado a profissionais responsáveis pelo gerenciamento de obras e pelo setor da qualidade em duas construtoras. Os resultados demonstraram que as empresas contatadas possuem o domínio da fase de definição de atividades, clientes e requisições, porém há possibilidade de implementação de ações e ferramentas aplicadas para o desenvolvimento de processos e produtos. Sendo assim, a pesquisa contribui para elencar os principais gargalos nos modelos de gerenciamento aplicados por empresas construtoras segundo a prática LSS.

Published
2020
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42. ANÁLISE DE APLICATIVOS PARA O GERENCIAMENTO DE OBRAS: USO PARA DIÁRIO DE OBRAS

Author

Ana Flavia Davanzo Lopes, Lucio Schiavon Yamamoto, and Sheyla M. B. Serra

Abstract

No momento atual, acontece a Quarta Revolução Industrial, na qual os meios digital, físico e biológico se unem formando a Indústria 4.0. Grande parte da indústria da construção civil se manteve atrasada em relação aos movimentos de modernização. No entanto, existe uma parcela dessa indústria que considera imprescindível a busca de novas tecnologias e metodologias de gestão que visem a eficiência de seus processos. O presente trabalho analisou como a Tecnologia de Informação e Comunicação (TIC) pode ser utilizada a fim de atingir impactos positivos na gestão de obras. Devido à sua importância no armazenamento de dados e comunicação dentro da construção civil, foi selecionado o documento do Diário de Obras para estudo comparativo entre três programas computacionais, visando averiguar o atendimento de parâmetros identificados. Concluiu-se, que os programas analisados atendem satisfatoriamente sua função de TIC, significando um avanço para substituição do tradicional registro no Diário de Obras da forma escrita para a forma virtual.

Published
2020
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43. Design, synthesis and biological evaluation of new carbazole derivatives as anti-cancer and anti-migratory agents

Author

Julia I. Medina, Linette Castillo-Pichardo, Zulma R. Toro Ramos, Eliud Hernandez, Cathyria M. Marrero-Serra, Cornelis Vlaar, and Ericka Vélez

Subjects
rac1 GTP-Binding Protein, 0301 basic medicine, Clinical Biochemistry, Carbazoles, Pharmaceutical Science, Antineoplastic Agents, Biochemistry, Article, Metastasis, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cell Movement, Cell Line, Tumor, Drug Discovery, medicine, Humans, Cytotoxic T cell, Molecular Biology, IC50, Cell Proliferation, Binding Sites, Carbazole, Organic Chemistry, Cancer, medicine.disease, In vitro, Protein Structure, Tertiary, Molecular Docking Simulation, 030104 developmental biology, chemistry, Cell culture, Drug Design, 030220 oncology & carcinogenesis, MCF-7 Cells, Cancer research, Molecular Medicine, Lead compound
Abstract

Based on the efficacy of EHop-016 as an inhibitor of migration and Rac1 activation, a new series of carbazole derivatives has been synthesized. Cytotoxic and anti-migratory effects of these compounds were evaluated in MCF-7 and MDA-MB-231 breast cancer cell lines. Preliminary investigations of their anticancer activity demonstrated that several compounds have moderate antiproliferative effects on cancer cell lines with GI50 values in the range of 13–50 µM. Furthermore, compounds 3b and 11b inhibit migration activity of metastatic cell line MDA-MB-231 by 32% and 34%, respectively. Compound 11b was shown to inhibit activation of the Rho GTPase Rac1 by 55% at 250 nM in both MDA-MB-231 and MDA-MB-435 cell lines. Compared with the IC50 of Rac1 inhibition by lead compound EHop-016 of 1.1 µM, compound 11b demonstrates 4X improved in vitro efficacy.

Published
2018
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44. Salvage of Upper Limb following a Severe Crushing Trauma: Immediate Reconstruction with a Free Flap and Subsequent Hyperbaric Oxygen Therapy

Author

M. P. Serra and P. Longhi

Subjects
Medicine
Abstract

A microsurgical latissimus dorsi flap was performed for resurfacing a large soft tissue defect of the forearm with exposure of the vital structures and contaminated wound. Early coverage of a defect is a generally accepted concept to achieve a better functional result. The authors present a case report where a free latissimus dorsi flap with subsequent hyperbaric oxygen therapy allowed a successful single stage reconstruction of this complex severely contaminated defect.

Published
2009
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46. Adherence to follow-up recommendation guidelines in long term breast cancer survivors, a SURBCAN cohort analysis using administrative databases

Author

Anna Jansana, Maximino Redondo, Teresa Sanz, Xavier Castells, M. Padilla-Ruiz, Mercè Comas, P. Santiá, M. Sala Serra, Laia Domingo, and I. de la Cura

Subjects
medicine.medical_specialty, Breast cancer, business.industry, Family medicine, medicine, Surgery, General Medicine, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, business, lcsh:RC254-282, Cohort study, Term (time)
Published
2021
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48. Automatic classification system for grazing, ruminating and resting behaviour of dairy sheep using a tri-axial accelerometer

Author

M. Acciaro, Giovanni Molle, Salvatore Pier Giacomo Rassu, Andrea Cabiddu, Carla Manca, R. Cossu, M. G. Serra, Corrado Dimauro, V. Giovanetti, Mauro Decandia, and M. Mameli

Subjects
geography, geography.geographical_feature_category, General Veterinary, Coefficient of variation, 0402 animal and dairy science, 04 agricultural and veterinary sciences, Linear discriminant analysis, Accelerometer, 040201 dairy & animal science, Pasture, Standard deviation, Biting, Grazing, Statistics, 040103 agronomy & agriculture, 0401 agriculture, forestry, and fisheries, Animal Science and Zoology, Ruminating, Mathematics
Abstract

A device based on a tri-axial accelerometer was used to measure behavioural parameters of dairy sheep at pasture. Short tests were performed in grazing conditions to collect accelerometer data simultaneously with video recordings of sheep behavioural activities (grazing, ruminating and resting). The raw acceleration data was processed to create 12 variables: mean, variance and inverse coefficient of variation (ICV; mean/standard deviation) for the X-, Y- and Z-axis and the resultant at 1-min intervals. A database inclusive of the 12 acceleration variables and the three behavioural activities detected for each minute was then created. Three multivariate statistical techniques were used to discriminate the behavioural activities using the acceleration data: stepwise discriminant analysis (SDA), canonical discriminant analysis (CDA), and discriminant analysis (DA). Based on the acceleration variables selected by SDA, the subsequent CDA significantly discriminated the three behaviours by extracting two canonical functions. The first canonical function (CAN1) discriminated the grazing activity from the resting and ruminating, whereas the second (CAN2) differentiated the grazing from the ruminating behaviour. After bootstrap resampling, the DA correctly assigned 93.0% of minutes to behavioural activities. Stepwise regression analysis was used to estimate the rate of biting(total number of bites/min) using a subset of acceleration data that contained only minutes in which sheep were grazing. In this case, 15 variables were tested and out of them, only one was selected, the sum of X-axis value per minute (SX), which explained 65% of the total variation of the rate of biting .

Published
2017
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49. Graphene oxide nanocomposite magnetic microbeads for the remediation of positively charged aromatic compounds

Author

M Dalla Serra, Luca Minati, Massimiliano Clamer, Giorgio Speranza, and Victor Micheli

Subjects
Materials science, Nanostructure, Nanocomposite, Graphene, Oxide, magnetic beads, law.invention, Inorganic Chemistry, chemistry.chemical_compound, Sodium borohydride, Adsorption, chemistry, Chemical engineering, law, Self-healing hydrogels, Agarose
Abstract

Integrating graphene as an inorganic nanostructure within a hydrogel matrix enables the creation of a unique hybrid composite combining the peculiar chemical and physical properties of graphene with the high porosity and stability of hydrogels as for example agarose gel. As a consequence, the resulting material forms a double-network system providing advantages deriving from both the components. In this study, we present the synthesis of novel magnetic porous agarose-based graphene oxide microbeads for the adsorption and separation of positively charged aromatic molecules. The hydrogel-based graphene oxide beads revealed an ultrafast adsorption kinetics for positively charged aromatic dyes. We tested this material for the purification of fluorescent-tagged biomolecules. In addition, reduced graphene oxide microbeads were decorated with palladium nanoparticles, showing a high catalytic activity towards the reduction of dyes by sodium borohydride. Our results show that magnetic agarose based graphene microbeads with enhanced physical-chemical properties can be used for several biochemical applications.

Published
2020
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50. SMN-primed ribosomes modulate the translation of transcripts related to Spinal Muscular Atrophy

Author

M Dalla Serra, Toma Tebaldi, Marta Marchioretto, Elena Perenthaler, Gabriella Viero, Massimiliano Clamer, Paola Bernabò, Julia Orri, Thomas H. Gillingwater, Alessandro Quattrone, Federica Maniscalco, Ejn Groen, Fabio Lauria, and Alberto Inga

Subjects
0303 health sciences, Translation (biology), Spinal muscular atrophy, Motor neuron, Biology, SMA, medicine.disease, Ribosome, Cell biology, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, nervous system, Proteome, medicine, Coding region, 030217 neurology & neurosurgery, Function (biology), 030304 developmental biology
Abstract

The contribution of ribosome heterogeneity and ribosome-associated factors to the molecular control of proteomes in health and disease remains enigmatic. We demonstrate that Survival Motor Neuron (SMN) protein, loss of which causes the neuromuscular disease spinal muscular atrophy (SMA), binds to ribosomes and that this interaction is tissue-dependent. SMN-primed ribosomes are positioned within the first five codons of a set of mRNAs which are enriched in IRES-like sequences in the 5’UTR and rare codons at the beginning of their coding sequence. Loss of SMN at early-stages of SMA induces translational defectsin vivo,characterized by ribosome depletion in rare codons at the third and fifth position of the coding sequence. These positional defects cause ribosome depletion from mRNAs bound by SMN-primed ribosomes and translational impairment of proteins involved in motor neuron function and stability, including acetylcholinesterase. Thus, SMN plays a crucial role in the regulation of ribosome fluxes along mRNAs which encode proteins relevant to SMA pathogenesis.

Published
2019
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