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In this paper, we obtain the necessary and sufficient conditions for the weak/strong boundedness of the Calderón-Zygmund operators in generalized weighted Orlicz-Morrey spaces. We also study the boundedness of the commutators of Calderón-Zygmund operators on these spaces. Moreover, the boundedness of Calderón-Zygmund operators in the vector-valued setting is given., 25 pages

We consider solutions $u\in W^{1,p}\big(\Omega;\mathbb{R}^{N}\big)$ of the $p$-Laplacian PDE \begin{equation} \nabla\cdot\big(a(x)|Du|^{p-2}Du\big)=0,\notag \end{equation} for $x\in\Omega\subseteq\mathbb{R}^{n}$, where $\Omega$ is open and bounded. More generally, we consider solutions of the elliptic system \begin{equation} \nabla\cdot\left(a(x)g'\big(a(x)|Du|\big)\frac{Du}{|Du|}\right)=0\text{, }x\in\Omega\notag \end{equation} as well as minimizers of the functional \begin{equation} \int_{\Omega}g\big(a(x)|Du|\big)\ dx.\notag \end{equation} In each case, the coefficient map $a\ : \ \Omega\rightarrow\mathbb{R}$ is only assumed to be of class $VMO(\Omega)\cap L^{\infty}(\Omega)$, which means that it may be discontinuous. Without assuming that $x\mapsto a(x)$ has any weak differentiability, we show that $u\in\mathscr{C}_{\text{loc}}^{0,\alpha}(\Omega)$ for each $0, Comment: Nonlinear Analysis

For $\Omega\subseteq\mathbb{R}^{n}$ an open and bounded region we consider solutions $u\in W_{\text{loc}}^{1,p(x)}\big(\Omega;\mathbb{R}^{N}\big)$, with $N>1$, of the $p(x)$-Laplacian system \begin{equation} \nabla\cdot\left(a(x)|Du|^{p(x)-2}Du\right)=0\text{, a.e. }x\in\Omega,\notag \end{equation} where concerning the coefficient function $x\mapsto a(x)$ we assume only that \begin{equation} a\in W^{1,q}(\Omega)\cap L^{\infty}(\Omega),\notag \end{equation} where $q>1$ is essentially arbitrary. This implies that the coefficient in the PDE can be highly irregular, and yet in spite of this we still recover that \begin{equation} u\in\mathscr{C}_{\text{loc}}^{0,\alpha}\big(\Omega_0\big),\notag \end{equation} for each $0, Comment: Journal of Differential Equations

The long term behavioural and biochemical effects of chronic chlordiazepoxide treatment during the period of neuronal maturation in the rat have been investigated. The administration to lactating mothers of chlordiazepoxide at very low doses (0.22 and 2.6 mg/kg) in their drinking water affects both behavioural and biochemical parameters in offspring at 60 days of age and undrugged since weaning. A deficit in the acquisition of the conditioned avoidance response in treated rats was observed, although no significant difference in spontaneous locomotor activity between control and treated rats was found. 3H-Flunitrazepam binding sites in cerebral cortex and hippocampus were decreased by the treatment, whereas no change was detected in cerebellum. Moreover, 3H-muscimol binding sites increased in hippocampus with no changes in cerebral cortex and cerebellum. According to the different regional distribution of benzodiazepine type 1 and type 2 receptors, we suggest that type 2 receptors are selectively affected by the treatment, and that the GABA ergic receptor system is also permanently altered by administration of chlordiazepoxide during early postnatal life.

We have studied a group of 349 institutionalized propositi with mental retardation, and found 12 fra(X)-positive cases among 155 males (7.7%) and 8 fra(X)-positive cases among 194 females (4.1%). The males had characteristic manifestations of the Martin-Bell syndrome. Another 7 males, who were initially considered "borderline", having expression of fra(X) less than 4% and a non-characteristic phenotype, were eventually considered negative. Among 5,624 patients (2,764 males and 2,860 females) that were admitted to the Pediatric Department of the University of Catania during the period July 1986 - June 1987, 210 (120 males and 90 females) had mental retardation. Of these, 75 were analyzed for the presence of fra(X) (q27.3); 5 males (0.18% of all males) and 2 females (0.07% of all females) were fra(X)-positive. The males had the Martin Bell syndrome phenotype. The presence of fra(X) (q27) was confirmed in another 4 male propositi that were referred to our outpatient services with a clinical diagnosis of Martin-Bell syndrome.

Toll-like receptors (TLRs) represent a conserved family of proteins widely expressed in eukaryotes. They play crucial roles in the innate immune system recognizing different pathogen-associated molecular patterns. In mammals the TLR family comprises 10-13 members, while a huge number of TLR-like genes were recovered in S.purpuratus[1-3]. The Paracentrotus lividus genome project recently generated a new highquality assembly of the genome that represents a valuable resource also for clarifying the evolutionary origin of immune system. In order to identify TLR genes in P.lividus, a genome wide survey was carried out and BLAT searches retrieved 119 TLR genes (PlivTLRs). Ab initio gene predictions and in silico analyses allowed us to compute gene structures and define TSS, start/stop codons and PolyA sites in the retrieved sequences. Remarkably, differently from other species, several PlivTLR genes possess one or two introns interrupting the coding region and two different predictions were often obtained, both compatible with TLR protein structures. To support predictions and to get functional information, we examined the available P.lividus transcriptomes. Based on transcriptomic analysis, more than 50% of PlivTLRs resulted expressed and ~30% of genes without matching sequences probably represent pseudogenes, due to defects in TSS, coding region or PolyA signal. A molecular phylogenetic analysis aiming to classify PlivTLRs and gain insights into TLR evolution is in processing. Comparative genome analyses confirm the massive expansion of such family in sea urchins and suggests that TLRs are likely to function as part of a fundamentally different immune mechanism. 1-3. Rast group (2006, 2012, 2015)

Human papillomavirus (HPV) is the agent of the most common sexually transmitted diseases causing a variety of clinical manifestations ranging from warts to cancer. Oncogenic HPV infection is the major cause of cervical cancer and less frequently of penile cancers. Its presence in semen is widely known, but the effects on fertility are still controversial. We developed a new approach to evaluate virus localisation in the different semen components. We analysed also the specific genotype localisation and viral DNA quantity by qPCR. Results show that HPV DNA can be identified in every fraction of semen: spermatozoa, somatic cells and seminal plasma. Different samples can contain the HPV DNA in different fractions and several HPV genotypes can be found in the same fraction. Additionally, different fractions may contain multiple HPV genotypes in different relative quantity. We analysed the wholeness of HPV DNA in sperm cells by qPCR. In one sample more than half of viral genomes were defective, suggesting a possible recombination event. The new method allows to easily distinguish different sperm infections and to observe the possible effects on semen. The data support the proposed role of HPV in decreased fertility and prompt new possible consequences of the infection in semen.