Search

Your search keyword '"Müther, Michael"' showing total 194 results
Start Over Author "Müther, Michael"
194 results on '"Müther, Michael"'

4. Localization of protoporphyrin IX during glioma-resection surgery via paired stimulated Raman histology and fluorescence microscopy

Author

Nasir-Moin, Mustafa, Wadiura, Lisa Irina, Sacalean, Vlad, Juros, Devin, Movahed-Ezazi, Misha, Lock, Emily K., Smith, Andrew, Lee, Matthew, Weiss, Hannah, Müther, Michael, Alber, Daniel, Ratna, Sujay, Fang, Camila, Suero-Molina, Eric, Hellwig, Sönke, Stummer, Walter, Rössler, Karl, Hainfellner, Johannes A., Widhalm, Georg, Kiesel, Barbara, Reichert, David, Mischkulnig, Mario, Jain, Rajan, Straehle, Jakob, Neidert, Nicolas, Schnell, Oliver, Beck, Jürgen, Trautman, Jay, Pastore, Steve, Pacione, Donato, Placantonakis, Dimitris, Oermann, Eric Karl, Golfinos, John G., Hollon, Todd C., Snuderl, Matija, Freudiger, Christian W., Heiland, Dieter Henrik, and Orringer, Daniel A.

Published
2024
Full Text
View/download PDF

5. 'Gemeinsam an einem Strang ziehen': Skills-Lab Workshops Marburg-Göttingen – Ein Erfahrungsbericht [Heading in the same direction: The skills-lab workshops Marburg-Goettingen – A field report]

Author

Schiller, Matthias, Huber, Tobias, and Müther, Michael

Subjects
medical skills, peer-teaching, medical training-center, cooperation, ärztliche Fertigkeiten, medizinische Trainingszentrum, Kooperation, Peer-Teaching, Special aspects of education, LC8-6691, Medicine (General), R5-920
Abstract

[english] History: After the initiation of skills-labs in Marburg and Goettingen the peer-teaching students of both institutions saw a need for communication and cooperation. The primary goal of these ’skills-lab workshops’ was the exchange of already existing ideas for extracurricular peer-teaching, the development of new tutorials and long-term cooperation between the institutions.Methods: In January of 2010 the 1 ’skills-lab workshop’ Marburg-Goettingen was held at the ‘Marburg’s Interdisciplinary skills-lab’ (Maris, since 10/2008). The 2 workshop was held at the ‘Student’s trainings center of medical practice and simulation’ (STÄPS, since 10/2009) in Goettingen in October of 2010.Results and conclusion: Especially younger skills-labs can profit from an exchange with a more established Institution. Cooperations like these are the foundation for future exchange of ideas for new peer-teachings and the continuous improvement or a transfer of existing peer-teachings for skills-labs. We recommend bilateral exchanges like this to other and especially to new skills-labs.[german] Zielsetzung: Mit der Gründung von Skills-Labs an den medizinischen Fakultäten der Universitäten Marburg und Göttingen in den letzten drei Jahren entstand das Bedürfnis der in diesen Einrichtungen tätigen studentischen Tutoren nach Austausch. Das primäre Ziel eines gemeinsamen Workshops war der Austausch zur Angebots- und Qualitätsentwicklung und der längerfristigen Kooperation der beiden Standorte zur Ressourcenoptimierung.Methodik: An einem Wochenende im Januar 2010 hat auf studentische Initiative hin der „1. Skills-Lab Workshop Marburg-Göttingen“ in Marburg stattgefunden, veranstaltet vom Marburger interdisziplinären Skills-Lab (Maris, seit 10/2008) in Kooperation mit dem Studentisches Trainingszentrum Ärztlicher Praxis und Simulation (STÄPS, seit 10/2009). Der „2. Skills-Lab Workshop“ fand im Oktober 2010 in Göttingen statt. Ergebnisse und Schlussfolgerung: Die hier begonnene Kooperation zeigt, dass Skills-Labs „das Rad nicht unbedingt immer neu erfinden“ müssen. Durch den freundlichen und kollegialen „Anschub“ erfahrener Tutoren des jeweils anderen Standortes konnten sich Peer-Teaching-Erfahrungen unkompliziert ergänzen, um im eigenen Skills-Lab angewendet zu werden. Wir können vor allem den im Aufbau befindlichen Skills-Labs empfehlen, in der Startphase ebenfalls zu kooperieren und voneinander zu lernen.

Published
2011
Full Text
View/download PDF

6. Importance of interdisciplinarity in modern oncology: results of a national intergroup survey of the Young Oncologists United (YOU)

Author

Mäurer, Matthias, Staudacher, Jonas, Meyer, Robert, Mäurer, Irina, Lazaridis, Lazaros, Müther, Michael, Huber, Tobias, Sommer, Nils P., Fleischmann, Daniel F., Käsmann, Lukas, Ziegler, Sonia, Kropf-Sanchen, Cornelia, Wikert, Julia, Pietzner, Klaus, Holzgreve, Adrien, Nestler, Tim, Siech, Carolin, Sturm, Max-Johann, Sulzer, Sabrina, Heinrich, Kathrin, and Stahler, Arndt

Published
2023
Full Text
View/download PDF

9. Expertise in surgical neuro-oncology. Results of a survey by the EANS neuro-oncology section

Author

Agrawal, Rachit, Albano, Luigi, Alexiou, George A., Ali, Amanj, Al-Mahfoudh, Rafid, Amoo, Michael, Anagnostopoulos, Christos, Bamps, Sven, Bandyopadhyay, Soham, Barone, Damiano G., Barone, Fabio, Barrit, Sami, Behling, Felix, Blaga, Alin, Boukas, Alexandros, Brennan, Paul, Butenschoen, Vicki M., Campello, Mauro, Cara, Areda, Chibbaro, Salvatore, Chrenko, Robert, Cifre Serra, Pere J., Clusmann, Hans, Corell, Alba, Cornelius, Jan F., D'Andrea, Marcello, Demetriades, Andreas K., De Vleeschouwer, Steven, Drexler, Richard, Duerinck, Johnny, Fanarjyan, Ruben V., Fernandez-Coello, Alejandro, Fountas, Kostas, Freiman, Thomas M., Gadzhiagaev, Vadim, Georgiopoulos, Miltiadis, Gilis, Nathalie, Golubovic, Jagos, Lippi Fernandes, Eric Goulin, Grasso, Giovanni, Guerrini, Francesco, Gulsuna, Beste, Hill, Ciaran S., Höhne, Julius, Holling, Markus, Iarmoliuk, Ievgenii, Ioan-Alexandru, Florian, Ius, Tamara, Jacikevicius, Kestutis, Jakola, Asgeir S., Jakubowski, Paweł, Kalantzis, Georgios, Karabatsou, Konstantina, Kirollos, Ramez, König, Ralph, Kozyrev, Danil A., Krex, Dietmar, Ladisich, Barbara, Lau, Ruth, Lizunou, Yauhen, Lombard, Arnaud, Low, Hu Liang, Alves, José Luís, Maghrabi, Yazid, Mammi, Marco, Marji, Ala, Massimi, Luca, Mavridis, Ioannis, McLean, Aaron Lawson, Lawson McLean, Anna C., Meyer, Bernhard, Mohme, Malte, Branco, Pedro Moura, Müther, Michael, Musleh, Issam, Nasiri, Danial, Navarro, Ramon, Omerhodzic, Ibrahim, Oppong, Marvin Darkwah, Paidakakos, Nikolaos A., Pantera, Zoi, Patel, Mohammed A., Pawlowski, Mateusz, Petridis, Athanasios, Praeger, Adrian J., Price, Stephen, Ricklefs, Franz, Rigante, Luigi, Ringel, Florian, Robe, Pierre A., Rössler, Karl, Sá-Marta, Eduarda, Sanmillan, Jose L., Scerrati, Alba, Schneider, Matthias, Schroeder, Henry W.S., Schwake, Michael, Shoaib, Mohamed, Sirbu, Octavian Mihai, Sistiaga, Iñigo L., Skajster, Tomasz J., Sliauzys, Albertas, Sokotukhin, Vitaly, Soleman, Jehuda, Stoecklein, Veit M., Suero Molina, Eric, Świątnicki, Wojciech, Syrmos, Νikolaos, Taddei, Graziano, Taher, Avin, Tamarit, Martin, Laan, Mark ter, Theocharous, Theocharis, Thijs, Dieter, Trakolis, Leonidas, Truffelli, Monica, Weiss, Miriam, Uhl, Eberhard, Valentini, Laura Grazia, Vanhauwaert, Dimitri, Zebian, Bassel, Zivkovic, Bojana, Zoli, Matteo, Gousias, K., Hoyer, A., Mazurczyk, L.A., Bartek, J., Jr., Bruneau, M., Celtikci, E., Foroglou, N., Freyschlag, C., Grossman, R., Jungk, C., Metellus, P., Netuka, D., Rola, R., Schucht, P., Senft, C., Signorelli, F., Vincent, A.J.P.E., and Simon, M.

Published
2024
Full Text
View/download PDF

13. Efficacy and Low Toxicity of Normo-Fractionated Re-Irradiation with Combined Chemotherapy for Recurrent Glioblastoma—An Analysis of Treatment Response and Failure.

Author

Pepper, Niklas Benedikt, Prange, Nicholas Grischa, Troschel, Fabian Martin, Kröger, Kai, Oertel, Michael, Kuhlmann, Tanja, Müther, Michael, Grauer, Oliver, Stummer, Walter, and Eich, Hans Theodor

Subjects
THERAPEUTIC use of antineoplastic agents, DRUG toxicity, GLIOMAS, CANCER relapse, PATIENT safety, TEMOZOLOMIDE, ADJUVANT treatment of cancer, RADIATION injuries, CHEMORADIOTHERAPY, TREATMENT effectiveness, RETROSPECTIVE studies, DESCRIPTIVE statistics, DRUG efficacy, MEDICAL records, ACQUISITION of data, COMPARATIVE studies, SURVIVAL analysis (Biometry), PROGRESSION-free survival, RADIATION doses, OVERALL survival
Abstract

Simple Summary: In this single-center retrospective analysis of 101 patients with recurrent glioblastoma, we demonstrate the benefit of a multimodal treatment approach with normo-fractionated re-RT with combined alkylating chemotherapy after surgical resection. Additionally, questions of patient selection, treatment tolerability, and patterns of relapse are addressed. Multimodal Treatment with re-resection followed by re-irradiation in combination with alkylating chemotherapy achieved the best results, especially when a combination of two agents (TMZ and CCNU) is used. Treatment was tolerated well with little evidence of radionecrosis or hematological toxicity and mean overall survival was 11.3 months (mean progression free survival: 9.5 months). No influence of second-line chemotherapy on patterns of relapse was detected. Background: Glioblastoma is the most common malignant brain tumor in adults. Even after maximal safe resection and adjuvant chemoradiotherapy, patients normally relapse after a few years or even months. Standard treatment for recurrent glioblastoma is not yet defined, with re-resection, re-irradiation, and systemic therapy playing key roles. Usually, re-irradiation is combined with concurrent chemotherapy, harnessing the radiosensitizing effects of alkylating agents. Methods: A retrospective analysis of 101 patients with recurrent glioblastoma treated with re-irradiation was conducted, evaluating the survival impact of concurrent chemotherapy regimens, as well as prior resection. Patients were subcategorized according to concurrent chemotherapy (temozolomide vs. CCNU vs. combination of both vs. none) and details are given regarding treatment toxicity and patterns of relapse after first- and second-line treatment. Results: Patients were treated with normo-fractionated re-irradiation (with prescription dose of ~40 Gy to the PTV), resulting in a moderate cumulative EQD2 (~100 Gy). The mean overall survival was 11.3 months (33.5 months from initial diagnosis) and mean progression free survival was 9.5 months. Prior resection resulted in increased survival (p < 0.001), especially when gross total resection was achieved. Patients who received concurrent chemotherapy had significantly longer survival vs. no chemotherapy (p < 0.01), with the combination of CCNU and TMZ achieving the best results. Overall survival was significantly better in patients who received the CCNU + TMZ combination at any time during treatment (first or second line) vs. monotherapy only. The treatment of larger volumes (mean PTV size = 112.7 cm3) was safe and did not result in worse prognosis or increased demand for corticosteroids. Overall, the incidence of high-grade toxicity or sequential radionecrosis (5%) was reasonably low and treatment was tolerated well. While second-line chemotherapy did not seem to influence patterns of relapse, patients who received TMZ + CCNU as first-line treatment had a tendency towards better local control with more out-field recurrence. Conclusions: Normo-fractionated re-irradiation appears to be safe and is accompanied by good survival outcomes, even when applied to larger treatment volumes. Patients amenable to undergo re-resection and achieving concurrent systemic therapy with alkylating agents had better OS, especially when gross total resection was possible. Based on existing data and experiences reflected in this analysis, we advocate for a multimodal approach to recurrent glioblastoma with maximal safe re-resection and adjuvant second chemoradiation. The combination of TMZ and CCNU for patients with methylated MGMT promoter yielded the best results in the primary and recurrent situation (together with re-RT). Normo-fractionated RT enables the use of more generous margins and is tolerated well. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

14. Intratumor heterogeneity and T cell exhaustion in primary CNS lymphoma

Author

Heming, Michael, Haessner, Svea, Wolbert, Jolien, Lu, I-Na, Li, Xiaolin, Brokinkel, Benjamin, Müther, Michael, Holling, Markus, Stummer, Walter, Thomas, Christian, Schulte-Mecklenbeck, Andreas, de Faria, Flavia, Stoeckius, Marlon, Hailfinger, Stephan, Lenz, Georg, Kerl, Kornelius, Wiendl, Heinz, Meyer zu Hörste, Gerd, and Grauer, Oliver M.

Published
2022
Full Text
View/download PDF

15. Expertise in Surgical Neuro-oncology. Results of a Survey by the EANS Neuro-oncology Section.

Author

Gousias, K., primary, Hoyer, A., additional, Mazurczyk, L.A., additional, Bartek, J., additional, Bruneau, M., additional, Celtikci, E., additional, Foroglou, N., additional, Freyschlag, C., additional, Grossman, R., additional, Jungk, C., additional, Metellus, P., additional, Netuka, D., additional, Rola, R., additional, Schucht, P., additional, Senft, C., additional, Signorelli, F., additional, Vincent, A.J.P.E., additional, Simon, M., additional, Agrawal, Rachit, additional, Albano, Luigi, additional, Alexiou, George A., additional, Ali, Amanj, additional, Al-Mahfoudh, Rafid, additional, Amoo, Michael, additional, Anagnostopoulos, Christos, additional, Bamps, Sven, additional, Bandyopadhyay, Soham, additional, Barone, Damiano G., additional, Barone, Fabio, additional, Barrit, Sami, additional, Behling, Felix, additional, Blaga, Alin, additional, Boukas, Alexandros, additional, Brennan, Paul, additional, Butenschoen, Vicki M., additional, Campello, Mauro, additional, Cara, Areda, additional, Chibbaro, Salvatore, additional, Chrenkol, Robert, additional, Cifre Serra, Pere J., additional, Clusmann, Hans, additional, Corell, Alba, additional, Cornelius, Jan F., additional, D'Andrea, Marcello, additional, Demetriades, Andreas K., additional, De Vleeschouwer, Steven, additional, Drexler, Richard, additional, Duerinck, Johnny, additional, Fanarjyan, Ruben V., additional, Fernandez-Coello, Alejandro, additional, Fountas, Kostas, additional, Freiman, Thomas M., additional, Gadzhiagaev, Vadim, additional, Georgiopoulos, Miltiadis, additional, Gilis, Nathalie, additional, Golubovic, Jagos, additional, Lippi Fernandes, Eric Goulin, additional, Grasso, Giovanni, additional, Guerrini, Francesco, additional, Gulsuna, Beste, additional, Hill, Ciaran S., additional, Höhne, Julius, additional, Holling, Markus, additional, Iarmoliuk, Ievgenii, additional, Ioan-Alexandru, Florian, additional, Ius, Tamara, additional, Jacikevicius, Kestutis, additional, Jakola, Asgeir S., additional, Jakubowski, Paweł, additional, Kalantzis, Georgios, additional, Karabatsou, Konstantina, additional, Kirollos, Ramez, additional, König, Ralph, additional, Kozyrev, Danil A., additional, Krex, Dietmar, additional, Ladisich, Barbara, additional, Lau, Ruth, additional, Lizunou, Yauhen, additional, Lombard, Arnaud, additional, Low, Hu Liang, additional, Alves, José Luís, additional, Maghrabi, Yazid, additional, Mammi, Marco, additional, Marji, Ala’, additional, Massimi, Luca, additional, Mavridis, Ioannis, additional, McLean, Aaron Lawson, additional, Lawson McLean, Anna C., additional, Meyer, Bernhard, additional, Mohme, Malte, additional, Branco, Pedro Moura, additional, Müther, Michael, additional, Musleh, Issam, additional, Nasiri, Danial, additional, Navarro, Ramon, additional, Omerhodzic, Ibrahim, additional, Oppong, Marvin Darkwah, additional, Paidakakos, Nikolaos A., additional, Pantera, Zoi, additional, Patel, Mohammed A., additional, Pawlowski, Mateusz, additional, Petridis, Athanasios, additional, Praeger, Adrian J., additional, Price, Stephen, additional, Ricklefs, Franz, additional, Rigante, Luigi, additional, Ringel, Florian, additional, Robe, Pierre A., additional, Rössler, Karl, additional, Sá-Marta, Eduarda, additional, Sanmillan, Jose L., additional, Scerrati, Alba, additional, Schneider, Matthias, additional, Schroeder, Henry W.S., additional, Schwake, Michael, additional, Shoaib, Mohamed, additional, Sirbu, Octavian Mihai, additional, Sistiaga, Iñigo L., additional, Skajster, Tomasz J., additional, Sliauzys, Albertas, additional, Sokotukhin, Vitaly, additional, Soleman, Jehuda, additional, Stoecklein, Veit M., additional, Molina, Eric Suero, additional, Świątnicki, Wojciech, additional, Syrmos, Νikolaos, additional, Taddei, Graziano, additional, Taher, Avin, additional, Tamarit, Martin, additional, Laan, Mark ter, additional, Theocharous, Theocharis, additional, Thijs, Dieter, additional, Trakolis, Leonidas, additional, Truffelli, Monica, additional, Weiss, Miriam, additional, Uhl, Eberhard, additional, Valentini, Laura Grazia, additional, Vanhauwaert, Dimitri, additional, Zebian, Bassel, additional, Zivkovic, Bojana, additional, and Zoli, Matteo, additional

Published
2024
Full Text
View/download PDF

18. TERT promoter mutation and chromosome 6 loss define a high-risk subtype of ependymoma evolving from posterior fossa subependymoma

Author

Thomas, Christian, Thierfelder, Felix, Träger, Malte, Soschinski, Patrick, Müther, Michael, Edelmann, Dominic, Förster, Alexandra, Geiler, Carola, Kim, Hee-yeong, Filipski, Katharina, Harter, Patrick N., Schittenhelm, Jens, Eckert, Franziska, Ntoulias, Georgios, May, Sven-Axel, Stummer, Walter, Onken, Julia, Vajkoczy, Peter, Schüller, Ulrich, Heppner, Frank L., Capper, David, Koch, Arend, Kaul, David, Paulus, Werner, Hasselblatt, Martin, and Schweizer, Leonille

Published
2021
Full Text
View/download PDF

21. Does Early Mobilization Following Resection of Spinal Intra-Dural Pathology Increase the Risk of Cerebrospinal Fluid Leaks?—A Dual-Center Comparative Effectiveness Research

Author

Schwake, Michael, primary, Krahwinkel, Sophia, additional, Gallus, Marco, additional, Schipmann, Stephanie, additional, Maragno, Emanuele, additional, Neuschmelting, Volker, additional, Perrech, Moritz, additional, Müther, Michael, additional, and Lenschow, Moritz, additional

Published
2024
Full Text
View/download PDF

22. NIMG-34. TEMPORAL MUSCLE THICKNESS AS A PROGNOSTIC MARKER IN A REAL-LIFE COHORT OF NEWLY DIAGNOSED MGMT PROMOTER METHYLATED GLIOBLASTOMA PATIENTS: A MULTICENTRIC IMAGING ANALYSIS

Author

Lazaridis, Lazaros, primary, Moenninghoff, Christoph, additional, Bumes, Elisabeth, additional, Spille, Dorothee Cäcilia, additional, Müther, Michael, additional, Schulz, Tim, additional, Heider, Sina, additional, Agkatsev, Sarina, additional, Schmidt, Teresa, additional, Blau, Tobias, additional, Oster, Christoph, additional, Stummer, Walter, additional, Kessler, Almuth Friederike, additional, Seidel, Clemens, additional, Grauer, Oliver, additional, Hau, Peter, additional, Sure, Ulrich, additional, Keyvani, Kathy, additional, Herrlinger, Ulrich, additional, Kleinschnitz, Christoph, additional, Stuschke, Martin, additional, Herrmann, Ken, additional, Deuschl, Cornelius, additional, Scheffler, Björn, additional, Kebir, Sied, additional, and Glas, Martin, additional

Published
2023
Full Text
View/download PDF

26. Adult intracranial ependymoma - relevance of DNA methylation profiling for diagnosis, prognosis and treatment

Author

Träger, Malte, primary, Schweizer, Leonille, additional, Eilís, Pérez, additional, Schmid, Simone, additional, Hain, Elisabeth G, additional, Dittmayer, Carsten, additional, Onken, Julia, additional, Fukuoka, Kohei, additional, Ichimura, Koichi, additional, Schüller, Ulrich, additional, Dührsen, Lasse, additional, Müther, Michael, additional, Paulus, Werner, additional, Thomas, Christian, additional, Gutt-Will, Marielena, additional, Schucht, Philippe, additional, Maragkou, Theoni, additional, Schittenhelm, Jens, additional, Eckert, Franziska, additional, Niyazi, Maximilian, additional, Fleischmann, Daniel, additional, Dorostkar, Mario, additional, Feyer, Petra, additional, May, Sven-Axel, additional, Moskopp, Dag, additional, Badakhshi, Harun, additional, Radke, Cornelia, additional, Walter, Jan, additional, Ehret, Felix, additional, Capper, David, additional, and Kaul, David, additional

Published
2023
Full Text
View/download PDF

27. Localization of protoporphyrin IX in glioma patients with paired stimulated Raman histology and two-photon excitation fluorescence microscopy

Author

Nasir-Moin, Mustafa, primary, Wadiura, Lisa, additional, Juros, Devin, additional, Movahed-Ezazi, Misha, additional, Lee, Matthew, additional, Weiss, Hannah, additional, Müther, Michael, additional, Alber, Daniel, additional, Ratna, Sujay, additional, Fang, Camila, additional, Suero-Molina, Eric, additional, Hellwig, Sönke, additional, Stummer, Walter, additional, Rössler, Karl, additional, Hainfellner, Johannes, additional, Widhalm, Georg, additional, Kiesel, Barbara, additional, Reichert, David, additional, Mischkulnig, Mario, additional, Jain, Rajan, additional, Smith, Andrew, additional, Straehle, Jakob, additional, Neidert, Nicolas, additional, Schnell, Oliver, additional, Beck, Jürgen, additional, Trautman, Jay, additional, Pastore, Steve, additional, Pacione, Donato, additional, Placantonakis, Dimitris, additional, Oermann, Eric, additional, Golfinos, John, additional, Hollon, Todd, additional, Snuderl, Matija, additional, Freudiger, Christian, additional, Heiland, Dieter Henrik, additional, and Orringer, Daniel, additional

Published
2022
Full Text
View/download PDF

31. SURG-24. QUANTITATIVE ANALYSIS OF TUMOR CELL DENSITY AND PROTOPORPHYRIN IX FLOURESCENCE IN GLIOMA PATIENTS USING PAIRED STIMULATED RAMAN HISTOLOGY AND TWO-PHOTON EXCITATION FLUORESCENCE MICROSCOPY

Author

Nasir-Moin, Mustafa, primary, Wadiura, Lisa Irina, additional, Juros, Devin, additional, Movahed-Ezazi, Misha, additional, Lee, Matthew, additional, Weiss, Hannah, additional, Müther, Michael, additional, Alber, Daniel, additional, Ratna, Sujay, additional, Fang, Camila, additional, Suero-Molina, Eric, additional, Hellwig, Sönke, additional, Stummer, Walter, additional, Rössler, Karl, additional, Hainfellner, Johannes, additional, Widhalm, Georg, additional, Kiesel, Barbara, additional, Reichert, David, additional, Mischkulnig, Mario, additional, Jain, Rajan, additional, Trautman, Jay, additional, Pastore, Steve, additional, Pacione, Donato, additional, Placantonakis, Dimitris, additional, Oermann, Eric, additional, Golfinos, John, additional, Hollon, Todd, additional, Snuderl, Matija, additional, Freudiger, Christian, additional, and Orringer, Daniel, additional

Published
2022
Full Text
View/download PDF

32. DISP-11. GENDER DISPARITY REGARDING WORK-LIFE BALANCE SATISFACTION AMONG GERMAN NEURO-ONCOLOGISTS: A YOUNGNOA SURVEY

Author

Kebir, Sied, primary, Lazaridis, Lazaros, additional, Wick, Wolfgang, additional, Platten, Michael, additional, Tabatabai, Ghazaleh, additional, Combs, Stephanie, additional, Schmidt, Teresa, additional, Agkatsev, Sarina, additional, Blau, Tobias, additional, Mäurer, Irina, additional, Kahlert, Ulf, additional, Sagerer, Andre, additional, Berberich, Anne, additional, Heider, Sina, additional, Müther, Michael, additional, Bodensohn, Raphael, additional, and Behling, Felix, additional

Published
2022
Full Text
View/download PDF

33. First clinical experience with fractionated intracavitary radioimmunotherapy using [177Lu]Lu-6A10-Fab fragments in patients with glioblastoma: a pilot study.

Author

Roll, Wolfgang, Müther, Michael, Böning, Guido, Delker, Astrid, Warneke, Nils, Gildehaus, Franz-Josef, Schäfers, Michael, Stummer, Walter, Zeidler, Reinhard, Reulen, Hans-Jürgen, and Stegger, Lars

Subjects
*RADIOIMMUNOTHERAPY, *GLIOBLASTOMA multiforme, *CARBONIC anhydrase, *SUBCUTANEOUS injections, *ABSORBED dose, *LUTETIUM compounds
Abstract

Background: Following resection and standard adjuvant radio- and chemotherapy, approved maintenance therapies for glioblastoma are lacking. Intracavitary radioimmunotherapy (iRIT) with 177Lu-labeled 6A10-Fab fragments targeting tumor-associated carbonic anhydrase XII and injected into the resection cavity offers a novel and promising strategy for improved tumor control. Methods: Three glioblastoma patients underwent tumor resection followed by standard radio- and chemotherapy. These patients with stable disease following completion of standard therapy underwent iRIT on compassionate grounds. After surgical implantation of a subcutaneous injection reservoir with a catheter into the resection cavity, a leakage test with [99mTc]Tc-DTPA was performed to rule out leakage into other cerebral compartments. IRIT comprised three consecutive applications over three months for each patient, with 25%, 50%, 25% of the total activity injected. A dosimetry protocol was included with blood sampling and SPECT/CT of the abdomen to calculate doses for the bone marrow and kidneys as potential organs at risk. Results: All three patients presented without relevant leakage after application of [99mTc]Tc-DTPA. Two patients underwent three full cycles of iRIT (592 MBq and 1228 MBq total activity). One patient showed histologically proven tumor progression after the second cycle (526 MBq total activity). No relevant therapy-associated toxicities or adverse events were observed. Dosimetry did not reveal absorbed doses above upper dose limits for organs at risk. Conclusions: In first individual cases, iRIT with [177Lu]Lu-6A10-Fab appears to be feasible and safe, without therapy-related side effects. A confirmatory multicenter phase-I-trial was recently opened and is currently recruiting. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

35. Protoporphyrin IX in serum of glioblastoma patients after 5-ALA administration - a potential biomarker?

Author

Walke, Anna, Krone, Christopher, Hellwig, Sönke, Müther, Michael, Stummer, Walter, König, Simone, and Suero-Molina, Eric

Subjects
ddc: 610, Medicine and health
Abstract

Objective: 5-Aminolevulinic acid (5-ALA)-mediated fluorescence-guided resection (FGR) maximizes tumor resection in high-grade glioma surgery, improving progression-free survival. Hereby, tumor tissue is identified by the pink color resulting from protoporphyrin IX (PPIX), which, induced by 5-ALA, accumulates [for full text, please go to the a.m. URL]

Published
2022
Full Text
View/download PDF

40. Additional file 2 of Intratumor heterogeneity and T cell exhaustion in primary CNS lymphoma

Author

Heming, Michael, Haessner, Svea, Wolbert, Jolien, Lu, I-Na, Li, Xiaolin, Brokinkel, Benjamin, Müther, Michael, Holling, Markus, Stummer, Walter, Thomas, Christian, Schulte-Mecklenbeck, Andreas, de Faria, Flavia, Stoeckius, Marlon, Hailfinger, Stephan, Lenz, Georg, Kerl, Kornelius, Wiendl, Heinz, Meyer zu Hörste, Gerd, and Grauer, Oliver M.

Abstract

Additional file 2: Supplementary Methods.

Published
2022
Full Text
View/download PDF

41. Additional file 4 of Intratumor heterogeneity and T cell exhaustion in primary CNS lymphoma

Author

Heming, Michael, Haessner, Svea, Wolbert, Jolien, Lu, I-Na, Li, Xiaolin, Brokinkel, Benjamin, Müther, Michael, Holling, Markus, Stummer, Walter, Thomas, Christian, Schulte-Mecklenbeck, Andreas, de Faria, Flavia, Stoeckius, Marlon, Hailfinger, Stephan, Lenz, Georg, Kerl, Kornelius, Wiendl, Heinz, Meyer zu Hörste, Gerd, and Grauer, Oliver M.

Abstract

Additional file 4: Figure S1. Flow cytometry of B cells. Figure S2. Flow cytometry of T cells. Figure S3. Flow cytometry of T cell exhaustion markers. Figure S4. Histologies of PCNSL and glioblastoma biopsies. Figure S5. Patient characteristics of patient 1. Figure S6. Chemokines in DLBCL and PCNSL. Figure S7. Spatial transcriptomics in PCNSL

Published
2022
Full Text
View/download PDF

43. Combined Fluorescence-Guided Resection and Intracavitary Thermotherapy with Superparamagnetic Iron‐Oxide Nanoparticles for Recurrent High-Grade Glioma: Case Series with Emphasis on Complication Management

Author

Schwake, Michael, primary, Müther, Michael, additional, Bruns, Ann-Katrin, additional, Zinnhardt, Bastian, additional, Warneke, Nils, additional, Holling, Markus, additional, Schipmann, Stephanie, additional, Brokinkel, Benjamin, additional, Wölfer, Johannes, additional, Stummer, Walter, additional, and Grauer, Oliver, additional

Published
2022
Full Text
View/download PDF

47. Behandlung von Sanduhr-Tumoren der Wirbelsäule über einen minimal-invasiven posterolateralen Zugang mit nachfolgender Kohlefaser-verstärkter PEEK-Instrumentation

Author

Müther, Michael, Lüthge, Swenja, Gerwing, Mirjam, Stummer, Walter, and Schwake, Michael

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: Stand-alone minimally-invasive approaches for surgical management of spinal dumbbell tumors carry the risk of incomplete resections and impaired hemostasis. In contrast, more extensive approaches require subsequent instrumentation with metal artifacts impairing follow-up imaging. Here, we[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results