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3. Phase I trial of metastatic renal cell carcinoma with oral capecitabine and thalidomide

Author

Brossart, Peter, Müller, Stefan C., Gorschlüter, Marcus, Kim, Young, Hauser, Stefan, Kraemer, Anja, and Schmidt-Wolf, Ingo G. H.

Subjects
metastasized renal cell carcinoma, 5-FU, thalidomide, phase I trial, Medicine
Abstract

Background: The highly vascular nature of renal carcinoma cells suggests that inhibition of angiogenesis may be beneficial in this disease. Thalidomide has been described as inhibitor of the fibroblast growth factor (FGF) and the vascular endothelial growth factor (VEGF). Therefore and in consideration of the promising response rates of the combination of IL-2, IFN-alpha and 5-FU [1] in metastatic renal cancer, we found it reasonable to test the combination of 5-FU and thalidomide. Thus, we conducted a phase I trial to determine safety, side effects and responses to such a treatment. Methods: Patients with metastasized renal cell cancer after nephrectomy and progress after IL-2 and interferon treatment, received oral 5-FU at a dose of 1250 mg/qm2 twice a day for two weeks, then after pausing a week, the oral application was restarted. In addition, oral thalidomide was applied constantly at a maximum dose of 400 mg/d. The combined therapy was given for three months. The primary endpoint was duration until disease progression, the secondary endpoint the response to treatment. Response was determined by CT scans three months after the end of treatment. Results: In total, 12 male patients participated in the trial and received the combined oral therapy. Concerning clinical response, one mixed response (8%), a stable disease in 4/12 patients (33%) and progression was seen in 7 patients (58%). The survival from the start of the therapy showed a median of 21 months with three patients being alive. At present, the longest survival after the therapy is 51 months. Conclusions: The combination of oral 5-FU and thalidomide showed clinical response with tolerable side effects. Further studies will be required to assess the outcome of this treatment regimen.

Published
2009

4. Seltene Penismissbildungen

Author

Mueller, Stefan C., Michel, Maurice Stephan, editor, W. Thüroff, Joachim, editor, Janetschek, Günter, editor, and Wirth, Manfred P., editor

Published
2023
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7. Urethritis posterior/Urethrorrhagie

Author

Müller, Stefan C., Stein, Raimund, Section editor, Michel, Maurice Stephan, editor, W. Thüroff, Joachim, editor, Janetschek, Günter, editor, and Wirth, Manfred P., editor

Published
2023
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24. Yet More Spirals

Author

Mair, Thomas, Dahlem, Markus A., Müller, Stefan C., Elitzur, Avshalom C., Series Editor, Merali, Zeeya, Series Editor, Padmanabhan, Thanu, Series Editor, Schlosshauer, Maximilian, Series Editor, Silverman, Mark P., Series Editor, Tuszynski, Jack A., Series Editor, Vaas, Rüdiger, Series Editor, Tsuji, Kinko, editor, and Müller, Stefan C., editor

Published
2019
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25. Generation of Spirals in Excitable Media

Author

Müller, Stefan C., Elitzur, Avshalom C., Series Editor, Merali, Zeeya, Series Editor, Padmanabhan, Thanu, Series Editor, Schlosshauer, Maximilian, Series Editor, Silverman, Mark P., Series Editor, Tuszynski, Jack A., Series Editor, Vaas, Rüdiger, Series Editor, Tsuji, Kinko, editor, and Müller, Stefan C., editor

Published
2019
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26. The Arts and Beyond

Author

Tsuji, Kinko, Müller, Stefan C., Elitzur, Avshalom C., Series Editor, Merali, Zeeya, Series Editor, Padmanabhan, Thanu, Series Editor, Schlosshauer, Maximilian, Series Editor, Silverman, Mark P., Series Editor, Tuszynski, Jack A., Series Editor, Vaas, Rüdiger, Series Editor, Tsuji, Kinko, editor, and Müller, Stefan C., editor

Published
2019
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27. Appearance in Nature

Author

Müller, Stefan C., Tsuji, Kinko, Elitzur, Avshalom C., Series Editor, Merali, Zeeya, Series Editor, Padmanabhan, Thanu, Series Editor, Schlosshauer, Maximilian, Series Editor, Silverman, Mark P., Series Editor, Tuszynski, Jack A., Series Editor, Vaas, Rüdiger, Series Editor, Tsuji, Kinko, editor, and Müller, Stefan C., editor

Published
2019
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28. Cultural History

Author

Tsuji, Kinko, Müller, Stefan C., Elitzur, Avshalom C., Series Editor, Merali, Zeeya, Series Editor, Padmanabhan, Thanu, Series Editor, Schlosshauer, Maximilian, Series Editor, Silverman, Mark P., Series Editor, Tuszynski, Jack A., Series Editor, Vaas, Rüdiger, Series Editor, Tsuji, Kinko, editor, and Müller, Stefan C., editor

Published
2019
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31. Autoren

Author

Ahrens, Marit, primary, Benz, Marcus, additional, Bergmann, Lothar, additional, Bokemeyer, Dirk, additional, Brinkkötter, Paul, additional, Ellinger, Jörg, additional, Fischereder, Michael, additional, Floege, Jürgen, additional, Grundmann, Franziska, additional, Halbritter, Jan, additional, Hoyer, Joachim, additional, John, Stefan, additional, Jordans, Isabelle, additional, Konik, Margarethe, additional, Kubiak, Nina, additional, Kühne, Lucas, additional, Kurschat, Christine, additional, Müller, Dominik, additional, Müller, Roman-Ulrich, additional, Müller, Stefan C., additional, Schönermarck, Ulf, additional, Schröppel, Bernd, additional, Thaiss, Friedrich, additional, Weber, Lutz T., additional, Witzke, Oliver, additional, and Wolf, Gunter, additional

Published
2022
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33. Autoreninnen und Autoren

Author

Ahrens, Marit, primary, Al-Batran, Salah-Eddin, additional, Armbrust, Robert, additional, Banek, Séverine, additional, Becker, Sven, additional, Bergmann, Lothar, additional, Bojunga, Jörg, additional, Brümmendorf, Tim Henrik, additional, Brunnberg, Uta, additional, Bug, Gesine, additional, Burger, Michael, additional, Chromik, Jörg, additional, Chun, Felix K.-H., additional, Czauderna, Carolin, additional, Dumoulin, Franz Ludwig, additional, Dreyling, Martin, additional, El-Balat, Ahmed, additional, Ellinger, Jörg, additional, Elsner, Susanne, additional, Enßle, Julius C., additional, Fottner, Christian, additional, Galle, Peter R., additional, Gökbuget, Nicola, additional, Götze, Thorsten Oliver, additional, Halbsguth, Teresa, additional, Höh, Benedikt, additional, Hohenberger, Peter, additional, Hübner, Joachim, additional, Hübner, Jutta, additional, Isfort, Susanne, additional, Kasper, Bernd, additional, Katalinic, Alexander, additional, Kestler, Angelika, additional, Khodamoradi, Yascha, additional, Kleemann, Johannes, additional, Kluth, Luis A., additional, Köhler, Viktoria F., additional, Kollmar, Otto, additional, Koschmieder, Steffen, additional, Lang, Fabian, additional, Makowka, Philipp, additional, Mallmann, Peter, additional, Mallmann-Gottschalk, Nina, additional, Mandel, Philipp, additional, Maurer, Gabriele, additional, Mayer, Arnulf, additional, Meissner, Markus, additional, Menge, Franka, additional, Middeke, Jan Moritz, additional, Miesbach, Wolfgang, additional, Möhler, Markus, additional, Möbus, Volker, additional, Müller, Stefan C., additional, Musholt, Thomas J., additional, Nauck, Friedemann, additional, Oellerich, Thomas, additional, Özistanbullu, Deniz, additional, Porschen, Rainer, additional, Pox, Christian, additional, Richter, Konrad Klaus, additional, Sauerbruch, Tilman, additional, Scheich, Sebastian, additional, Schetelig, . Johannes, additional, Schmidberger, Heinz, additional, Schnürch, Hans-Georg, additional, Sebastian, Martin, additional, Sehouli, Jalid, additional, Seifart, Ulf, additional, Serve, Hubert, additional, Seufferlein, Thomas, additional, Shaid, Shabnam, additional, Soysal, Savas D., additional, Steffen, Björn, additional, Steinbach, Joachim P., additional, Stratmann, Jan A., additional, Tsoukakis, Ioannis, additional, Ullrich, Evelyn, additional, Vehreschild, Janne, additional, Metzler, Ivana von, additional, Wolff, Michael von, additional, Voß, Martin, additional, Wagner, Sebastian, additional, Weber, Matthias M., additional, Wege, Henning, additional, Weis, Joachim, additional, Welte, Maria-Noemi, additional, Wenzel, Mike, additional, Wolf, Timo, additional, and Zurmeyer, David, additional

Published
2022
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34. Unpinning of Spiral Waves

Author

Luengviriya, Jiraporn, Sutthiopad, Malee, Phantu, Metinee, Porjai, Porramain, Müller, Stefan C., Luengviriya, Chaiya, Müller, Stefan C., editor, Plath, Peter J., editor, Radons, Günter, editor, and Fuchs, Armin, editor

Published
2018
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44. Electric Field Effects in Chemical Patterns

Author

Dähmlow, Patricia, Luengviriya, Chaiya, Müller, Stefan C., Hull, Robert, Series editor, Jagadish, Chennupati, Series editor, Osgood, Richard M., Series editor, Parisi, Jürgen, Series editor, Seong, Tae-Yeon, Series editor, Uchida, Shin-ichi, Series editor, Wang, Zhiming M., Series editor, and Müller, Stefan C., editor

Published
2015
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48. Effect of Hospital and Surgeon Case Volume on Perioperative Quality of Care and Short-term Outcomes After Radical Cystectomy for Muscle-invasive Bladder Cancer: Results From a European Tertiary Care Center Cohort

Author

Bartsch, Georg, Brookman-May, Sabine, Buchner, Alexander, Durschnabel, Melanie, Ellinger, Jörg, Froehner, Michael, Georgieva, Galia, Gördük, Murat, Grimm, Marc-Oliver, Hadaschik, Boris, Haferkamp, Axel, Hakenberg, Oliver W., Hartmann, Florian, Herrmann, Edwin, Hertle, Lothar, Hohenfellner, Markus, Janetschek, Georg, Kraischits, Nicole, Krausse, Annerose, Lusuardi, Lukas, Michel, Maurice S., Moritz, Rudolf, Müller, Stefan C., Novotny, Vladimir, Nuhn, Philipp, Pahernik, Sascha, Palisaar, Rein-Jüri, Ponholzer, Anton, Protzel, Chris, Roigas, Jan, Schmid, Marianne, Schramek, Paul, Seitz, Christian, Sikic, Danijel, Stief, Christian G., Syring, Isabella, Vallo, Stefan, Wagenlehner, Florian M., Weidner, Wolfgang, Wirth, Manfred P., Vetterlein, Malte W., Meyer, Christian P., Leyh-Bannurah, Sami-Ramzi, Mayr, Roman, Gierth, Michael, Fritsche, Hans-Martin, Burger, Maximilian, Keck, Bastian, Wullich, Bernd, Martini, Thomas, Bolenz, Christian, Pycha, Armin, Hanske, Julian, Roghmann, Florian, Noldus, Joachim, Bastian, Patrick J., Gilfrich, Christian, May, Matthias, Rink, Michael, Chun, Felix K.-H., Dahlem, Roland, Fisch, Margit, and Aziz, Atiqullah

Published
2017
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50. The Use of Neoadjuvant Chemotherapy in Patients With Urothelial Carcinoma of the Bladder: Current Practice Among Clinicians

Author

Martini, Thomas, Gilfrich, Christian, Mayr, Roman, Burger, Maximilian, Pycha, Armin, Aziz, Atiqullah, Gierth, Michael, Stief, Christian G., Müller, Stefan C., Wagenlehner, Florian, Roigas, Jan, Hakenberg, Oliver W., Roghmann, Florian, Nuhn, Philipp, Wirth, Manfred, Novotny, Vladimir, Hadaschik, Boris, Grimm, Marc-Oliver, Schramek, Paul, Haferkamp, Axel, Colleselli, Daniela, Kloss, Birgit, Herrmann, Edwin, Fisch, Margit, May, Matthias, and Bolenz, Christian

Published
2017
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