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769 results on '"Müller, Lothar"'

2. Alternating gemcitabine plus nab-paclitaxel and gemcitabine alone versus continuous gemcitabine plus nab-paclitaxel after induction treatment of metastatic pancreatic cancer (ALPACA): a multicentre, randomised, open-label, phase 2 trial

Author

Dorman, Klara, Boeck, Stefan, Caca, Karel, Reichert, Maximilian, Ettrich, Thomas J, Oettle, Helmut, Waidmann, Oliver, Modest, Dominik P, Müller, Lothar, Michl, Patrick, Kanzler, Stephan, Pink, Daniel, Reinacher-Schick, Anke, Geißler, Michael, Pelz, Henning, Kunzmann, Volker, Held, Swantje, Schichtl, Thomas, Heinemann, Volker, and Kullmann, Frank

Published
2024
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5. Checkpoint Inhibitor Monotherapy in Potentially Trial-Eligible or Trial-Ineligible Patients With Metastatic NSCLC in the German Prospective CRISP Registry Real-World Cohort (AIO-TRK-0315)

Author

Ababei, Juliana, Alt, Jürgen, Ammon, Andreas, Anhuf, Jürgen, Azeh, Ivo, Bauer, Stefan, Behringer, Dirk, Berger, Winfried, Bernhardt, Christiane, Bertram, Mathias, Boesche, Michael, Bohnet, Sabine, Bruch, Harald-Robert, Brückl, Wolfgang, Burkhard-Meier, Ulrike, Christopoulos, Petros, Däßler, Klaus-Ulrich, de Wit, Maike, Dechow, Tobias, Depenbusch, Reinhard, Dietze, Lutz, Dommach, Markus, Dörfel, Steffen, Eberhardt, Wilfried, Elender, Corinna, Elsel, Wolfgang, Emde, Till-Oliver, Faehling, Martin, Fietz, Thomas, Fischer, Jürgen R., Flieger, Dimitri, Freidt, Anke, Freier, Werner, Frenzel, Christian, Fuchs, Florian, Fuchs, Roswitha, Gaska, Tobias, Gleiber, Wolfgang, Grah, Christian, Griesinger, Frank, Grohé, Christian, Groschek, Matthias, Güldenzoph, Björn, Günther, Andreas, Haas, Siegfried, Hackenthal, Matthias, Hagen, Volker, Hahn, Lars, Hannig Carla, Verena, Hansen, Richard, Harich, Hanns-Detlev, Heilmann, Monika, Heinrich, Kathrin, Hering-Schubert, Christiane, Heßling, Jörg, Hoffknecht, Petra, Hortig, Patricia, Hübner, Gerdt, Hummel, Horst-Dieter, Hutzschenreuter, Ulrich, Illmer, Thomas, Innig, Georg, Jaeschke, Bastian, Junghanß, Christian, Kaiser, Ulrich, Kamal, Haytham, Kambartel, Kato, Kern, Jens, Kimmich, Martin, Kingreen, Dorothea, Kirchen, Heinz, Klausmann, Martine, Klein, Ortwin, Kokowski, Konrad, Körber, Wolfgang, Kortsik, Cornelius, Koschel, Dirk, Krämer, Benoit, Krammer-Steiner, Beate, Laack, Eckart, Lamberti, Christof, Leistner, Rumo David, Losem, Christoph, Lück, Andreas, Maintz, Christoph, Martin, Kerstin, Medgenberg, Dirk, Metzenmacher, Martin, Meyer zum Büschenfelde, Christian, Meyn, Philipp, Moorahrend, Enno, Müller, Annette, Müller, Lothar, Neise, Michael, Nückel, Holger, Nusch, Arnd, Overbeck, Tobias, Pelz, Henning, Petersen, Volker, Peuser, Bettina, Plath, Margarete, Randerath, Winfried J., Rauh, Jacqueline, Reck, Martin, Reichert, Dietmar, Reinmuth, Niels, Reiser, Marcel, Repp, Roland, Reschke, Daniel, Rittmeyer, Achim, Rodemer, Yolanda, Sackmann, Sandra, Sadjadian, Parvis, Sandner, Reiner, Sauer, Annette, Schäfer, Harald, Schaudt, Christoph, Schlag, Rudolf, Schmidt, Burkhard, Schmitz, Stephan, Schröder, Jan, Schroeder, Michael, Schulze, Mathias, Schumann, Christian, Schütte, Wolfgang, Schwaiblmair, Martin, Schwindt Peter, Florian, Sebastian, Martin, Seese, Bernd, Seipelt, Gernot, Sorgenfrei, Thomas, Steiff, Johannes, Steiniger, Heike, Trarbach, Tanja, Tufman, Amanda, Uhlig, Jens, Vehling-Kaiser, Ursula, von der Heyde, Eyck, von Verschuer, Ulla, Waller, Cornelius, Wehler, Thomas, Weißenborn, Georg, Weißinger, Florian, Wermke, Martin, Wesseler, Claas, Wiegand, Jörg, Wilhelm, Stefan, Wilke, Jochen, Zahn, Mark-Oliver, Zaiss, Matthias, Zeth, Matthias, Eberhardt, Wilfried E.E., Brueckl, Wolfgang M., Jänicke, Martina, Fleitz, Annette, Zacharias, Stefan, Hipper, Annette, Groth, Annika, Weichert, Wilko, and Thomas, Michael

Published
2024
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6. Understanding and Monitoring Chemical and Biological Soil Degradation

Author

Saljnikov, Elmira, Lavrishchev, Anton, Römbke, Jörg, Rinklebe, Jörg, Scherber, Christoph, Wilke, Berndt-Michael, Tóth, Tibor, Blum, Winfried E. H., Behrendt, Undine, Eulenstein, Frank, Mirschel, Wilfried, Meyer, Burghard C., Schindler, Uwe, Urazaliev, Kairat, Mueller, Lothar, Mueller, Lothar, Series Editor, Saljnikov, Elmira, editor, Lavrishchev, Anton, editor, and Eulenstein, Frank, editor

Published
2022
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8. Understanding Soils: Their Functions, Use and Degradation

Author

Saljnikov, Elmira, Eulenstein, Frank, Lavrishchev, Anton, Mirschel, Wilfried, Blum, Winfried E. H., McKenzie, Blair M., Lilburne, Linda, Römbke, Jörg, Wilke, Berndt-Michael, Schindler, Uwe, Mueller, Lothar, Mueller, Lothar, Series Editor, Saljnikov, Elmira, editor, Lavrishchev, Anton, editor, and Eulenstein, Frank, editor

Published
2022
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9. Nivolumab Switch Maintenance Therapy After Tyrosine Kinase Inhibitor Induction in Metastatic Renal Cell Carcinoma: A Randomized Clinical Trial by the Interdisciplinary Working Group on Renal Tumors of the German Cancer Society (NIVOSWITCH; AIO-NZK-0116ass)

Author

Grünwald, Viktor, Ivanyi, Philipp, Zschäbitz, Stefanie, Wirth, Manfred, Staib, Peter, Schostak, Martin, Dargatz, Philip, Müller, Lothar, Metz, Michael, Bergmann, Lothar, Steiner, Thomas, Welslau, Martin, Lorch, Anja, Rafiyan, Reza, Hellmis, Eva, Darr, Cristopher, Schütt, Philipp, Meiler, Johannes, Kretz, Thomas, Loidl, Wolfgang, Flörcken, Anne, Mänz, Martin, Hinke, Axel, Hartmann, Arndt, and Grüllich, Carsten

Published
2023
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10. Health-related quality of life in patients with RAS wild-type metastatic colorectal cancer treated with fluorouracil and folinic acid with or without panitumumab as maintenance therapy: a prespecified secondary analysis of the PanaMa (AIO KRK 0212) trial

Author

Ballhausen, Alexej, Karthaus, Meinolf, Fruehauf, Stefan, Graeven, Ullrich, Müller, Lothar, König, Alexander Otto, von Weikersthal, Ludwig Fischer, Sommerhäuser, Greta, Alig, Annabel Helga Sophie, Goekkurt, Eray, Meyer-Knees, Johanna Wanda, Kurreck, Annika, Stahler, Arndt, Held, Swantje, Kasper, Stefan, Heinrich, Kathrin, Heinemann, Volker, Stintzing, Sebastian, Trarbach, Tanja, and Modest, Dominik Paul

Published
2023
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11. Fast and label-free automated detection of microsatellite status in early colon cancer using artificial intelligence integrated infrared imaging

Author

Gerwert, Klaus, Schörner, Stephanie, Großerueschkamp, Frederik, Kraeft, Anna–Lena, Schuhmacher, David, Sternemann, Carlo, Feder, Inke S., Wisser, Sarah, Lugnier, Celine, Arnold, Dirk, Teschendorf, Christian, Mueller, Lothar, Timmesfeld, Nina, Mosig, Axel, Reinacher-Schick, Anke, and Tannapfel, Andrea

Published
2023
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12. Depth of response of induction therapy and consecutive maintenance treatment in patients with RAS wild-type metastatic colorectal cancer: An analysis of the PanaMa trial (AIO KRK 0212)

Author

Sommerhäuser, Greta, Kurreck, Annika, Beck, Alexander, Fehrenbach, Uli, Karthaus, Meinolf, Fruehauf, Stefan, Graeven, Ullrich, Mueller, Lothar, Koenig, Alexander O., v. Weikersthal, Ludwig F., Goekkurt, Eray, Haas, Siegfried, Stahler, Arndt, Heinemann, Volker, Held, Swantje, Alig, Annabel H.S., Kasper, Stefan, Stintzing, Sebastian, Trarbach, Tanja, and Modest, Dominik P.

Published
2023
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13. Exploring Agricultural Landscapes: Recent Progress and Opportunities for Eurasia

Author

Mueller, Lothar, Eulenstein, Frank, Schindler, Uwe, Mirschel, Wilfried, Behrendt, Undine, Sychev, Viktor G., Rukhovich, Olga V., Belichenko, Maya V., Sheudzhen, Askhad K., Romanenkov, Vladimir A., Trofimov, Ilya, Lukin, Sergey M., McKenzie, Blair M., Salnjikov, Elmira, Gutorova, Oksana, Onishenko, Ludmila, Saparov, Abdulla, Pachikin, Konstantin, Dannowski, Ralf, Hennings, Volker, Scherber, Christoph, Römbke, Jörg, Ivanov, Alexey I., Dronin, Nikolai M., Mueller, Lothar, Series Editor, Sychev, Viktor G., editor, Dronin, Nikolai M., editor, and Eulenstein, Frank, editor

Published
2021
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15. Optimizing Agricultural Landscapes: Measures Towards Prosperity and Sustainability

Author

Mueller, Lothar, Eulenstein, Frank, Mirschel, Wilfried, Schindler, Uwe, Sychev, Viktor G., Rukhovich, Olga V., Sheudzhen, Askhad K., Romanenkov, Vladimir, Lukin, Sergey M., McKenzie, Blair M., Jones, Michael, Dannowski, Ralf, Blum, Winfried E. H., Salnjikov, Elmira, Saparov, Abdulla, Pachikin, Konstantin, Hennings, Volker, Scherber, Christoph, Hoffmann, Jörg, Antrop, Marc, Garibaldi, Lucas, Carella, Dulce S. Gómez, Augstburger, Horacio, Schwilch, Gudrun, Angelstam, Per, Manton, Michael, Dronin, Nikolai M., Mueller, Lothar, Series Editor, Sychev, Viktor G., editor, Dronin, Nikolai M., editor, and Eulenstein, Frank, editor

Published
2021
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16. Agricultural Landscapes: History, Status and Challenges

Author

Mueller, Lothar, Eulenstein, Frank, Dronin, Nikolai M., Mirschel, Wilfried, McKenzie, Blair M., Antrop, Marc, Jones, Michael, Dannowski, Ralf, Schindler, Uwe, Behrendt, Axel, Rukhovich, Olga V., Sychev, Viktor G., Sheudzhen, Askhad K., Romanenkov, Vladimir A., Trofimov, Ilya, Robinson, Guy M., Schreg, Rainer, Blum, Winfried E. H., Salnjikov, Elmira, Saparov, Abdulla, Pachikin, Konstantin, Römbke, Jörg, Manton, Michael, Angelstam, Per, Hennings, Volker, Poulton, Paul, Mueller, Lothar, Series Editor, Sychev, Viktor G., editor, Dronin, Nikolai M., editor, and Eulenstein, Frank, editor

Published
2021
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17. Modelling and Simulation of Agricultural Landscapes

Author

Mirschel, Wilfried, Berg-Mohnicke, Michael, Wieland, Ralf, Wenkel, Karl-Otto, Terleev, Vitaly V., Topaj, Alex, Mueller, Lothar, Mueller, Lothar, Series Editor, Mirschel, Wilfried, editor, Terleev, Vitaly V., editor, and Wenkel, Karl-Otto, editor

Published
2020
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18. Exploring the molecular profile of localized colon cancer: insights from the AIO Colopredict Plus registry.

Author

Ekmekciu, Ira, Zucha, Doreen Maria, Christmann, Jens, Wisser, Sarah, Heuer, Vera, Sargin, Buelent, Hollerbach, Stephan, Lamberti, Christof, Müller, Lothar, Lugnier, Celine, Verdoodt, Berlinda, Denz, Robin, Terzer, Tobias, Feder, Inke, Reinacher-Schick, Anke, Tannapfel, Andrea, and Tischoff, Iris

Abstract

Introduction: Understanding the mutational landscape of colon cancer (CC) is crucial for targeted therapy development. Microsatellite instability (MSI-H), rat sarcoma (RAS), and B-Raf proto-oncogene, serine/threonine kinase (BRAF) mutations (MT) are pivotal markers. Further investigation into clinicopathological features of RAS and BRAF MT in microsatellite stable (MSS) and MSI-H tumors is warranted. Methods: A retrospective analysis of 4883 localized CC patients (pts.) was conducted. Molecular profiling assessed MSI, KRAS, NRAS, and BRAF MT. Correlation with clinicopathological data employed ANOVA and Chi-square tests. Disease-free survival (DFS) and overall survival (OS) were analyzed adjusting for age, gender, sidedness, UICC stage, Charlson Comorbidity Index (CCI). A Cox model incorporated all variables as covariates. Results: This analysis included 4883 pts. (2302 female/2572 male, 3865 (79.2%) MSS, 1018 (20.8%) MSI-H). MSS pts. had more All-Wild Type (WT), KRAS MT, and NRAS MT tumors vs. MSI-H pts. (42.1% vs. 21.1%; 39.8% vs. 15.4%; 3.6% vs. 0.7%; p<0.001 for each). BRAF MT tumors (95.5% BRAF V600E MT) were more prevalent in MSI-H individuals (62.8% vs. 8.1%, p<0.001). KRAS and BRAF MT tumors were more frequently right-sided, while BRAF MT tumors were associated with female gender, advanced disease stage, lymph node positivity, and poorer differentiation in the MSS subset (p<0.001). Common KRAS mutations included p.G12D (30.44%) and p.G12V (21.3%) in MSS and p.G13D (28.9%) and p.G12D (22.37%) in MSI-H. NRAS MT tumors were dominated by codon 61 mutations (51.7%). Survival analysis revealed worst prognosis in BRAF MT MSS tumors (DFS: HR 1.74 (95% CI 1.15-2.62, p=0.009; OS: HR 1.61 (95% CI 0.99-2.6), p=0.055). The 3-years DFS and 5-years OS rates were lowest in this subset (61.6% and 57.7% respectively). Discussion: These findings highlight the complex interplay between molecular subtypes, clinicopathological features, and survival outcomes in early CC. Further research is needed to elucidate underlying mechanisms and develop personalized treatment strategies. [ABSTRACT FROM AUTHOR]

Published
2024
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19. The CLL12 trial: ibrutinib vs placebo in treatment-naïve, early-stage chronic lymphocytic leukemia

Author

Langerbeins, Petra, Zhang, Can, Robrecht, Sandra, Cramer, Paula, Fürstenau, Moritz, Al-Sawaf, Othman, von Tresckow, Julia, Fink, Anna-Maria, Kreuzer, Karl-Anton, Vehling-Kaiser, Ursula, Tausch, Eugen, Müller, Lothar, Eckart, Michael Josef, Schlag, Rudolf, Freier, Werner, Gaska, Tobias, Balser, Christina, Reiser, Marcel, Stauch, Martina, Wendtner, Clemens-Martin, Fischer, Kirsten, Stilgenbauer, Stephan, Eichhorst, Barbara, and Hallek, Michael

Published
2022
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20. Climate change as the driving force behind the intensification of agricultural land use

Author

Eulenstein Frank, Saljnikov Elmira, Lukin Sergey, Sheudshen Askhad K., Rukhovich Olga, Schindler Uwe, Saparov Galymzhan, Pachikin Konstantin, Thielicke Matthias, Behrendt Axel, Armin Werner, Zivotić Ljubomir, and Müller Lothar

Subjects
climate change, crop production, intensification of land use, water balance, global agricultural production, sustainability, population growth, Microbiology, QR1-502, Botany, QK1-989
Abstract

Climate change in Europe will lead to new precipitation patterns over the coming years and the annual temperature will increase significantly. These changes in climate variables and the resulting effects on agricultural productivity must be differentiated regionally. Plant production depends on sufficient rainfall in summer and, in some regions, on the amount of rainfall in winter. In Central Europe, the amount of precipitation in summer will decrease in the coming decades due to climate change, while in some regions, the amount of winter precipitation will increase significantly. Agricultural production is likely to suffer severely as a result of rising summer temperatures and low water retention capacities in the soil. The effects of reduced summer precipitation and increased air temperatures are partially offset by the expected increased CO2 concentration. Therefore, the effects that changed climatic conditions have on crop production are sometimes less drastic in terms of crop yields. The greatest impact of climate change on land use is expected from increasing evapotranspiration and lower amounts of precipitation in the production of leachate. In addition to the expected mean changes, the occurrence of extreme weather conditions is key. Periods of drought in the growing season and heavy flooding as a result of extreme rainfall are to be expected. However, these events are very difficult or even impossible to predict. In addition to the effects that climate change will have on regional crop production, global changes will have a strong impact on world markets for agricultural products. Another consequence of climate change and population growth is a higher demand for agricultural products on world markets. This will lead to dramatic local land use changes and an intensification of agriculture that will transform existing crop production systems. The intensification caused by rising land and lease prices will primarily affect the maximization of the use of fertilizers and pesticides.

Published
2022
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21. Landscapes, Their Exploration and Utilisation: Status and Trends of Landscape Research

Author

Mueller, Lothar, Eulenstein, Frank, Mirschel, Wilfried, Antrop, Marc, Jones, Michael, McKenzie, Blair M., Dronin, Nikolai M., Kazakov, Lev K., Kravchenko, Valery V., Khoroshev, Alexander V., Gerasimova, Maria, Dannowski, Ralf, Schindler, Uwe, Ruhovich, Olga, Sychev, Viktor G., Sheudzhen, Askhad K., Couvet, Denis, Robinson, Guy M., Blum, Winfried, Joniak, Tomasz, Eisendle, Ursula, Trovato, Maria Gabriella, Salnjikov, Elmira, Haubold-Rosar, Michael, Knoche, Dirk, Köhl, Michael, Bartlett, Debbie, Hoffmann, Jörg, Römbke, Jörg, Glante, Frank, Sumina, Olga I., Saparov, Abdulla, Bukvareva, Elena, Terleev, Vitaly V., Topaj, Alex G., Kienast, Felix, Mueller, Lothar, Series Editor, and Eulenstein, Frank, editor

Published
2019
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22. Consensus molecular subtypes (CMS) as prognostic and predictive biomarkers of RAS wild-type (WT) metastatic colorectal cancer (mCRC): Pooled analysis of the randomized trials FIRE-1, FIRE-3, XELAVIRI, and PanaMa.

Author

Stahler, Arndt, primary, Modest, Dominik Paul, additional, Stintzing, Sebastian, additional, Held, Swantje, additional, Fischer von Weikersthal, Ludwig, additional, Müller, Lothar, additional, Graeven, Ullrich, additional, Decker, Thomas, additional, Heintges, Tobias, additional, Kahl, Christoph, additional, Scheithauer, Werner, additional, Kiani, Alexander, additional, Kaiser, Florian, additional, Schwaner, Ingo, additional, Fruehauf, Stefan, additional, Karthaus, Meinolf, additional, Trarbach, Tanja, additional, Klauschen, Frederik, additional, Horst, David, additional, and Heinemann, Volker, additional

Published
2024
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23. FU/FA maintenance therapy with or without panitumumab (pmab) in RAS wild-type metastatic colorectal cancer (mCRC) (PanaMa, AIO KRK 0212): Updated efficacy analyses.

Author

Modest, Dominik Paul, primary, Karthaus, Meinolf, additional, Fruehauf, Stefan, additional, Graeven, Ullrich, additional, Müller, Lothar, additional, Koenig, Alexander, additional, Fischer von Weikersthal, Ludwig, additional, Caca, Karel, additional, Goekkurt, Eray, additional, Haas, Siegfried, additional, Kurreck, Annika, additional, Held, Swantje, additional, Jarosch, Armin, additional, Horst, David, additional, Reinacher-Schick, Anke C., additional, Kasper, Stefan, additional, Heinemann, Volker, additional, Stintzing, Sebastian, additional, Trarbach, Tanja, additional, and Stahler, Arndt, additional

Published
2024
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24. Discussion of ABC7 Consensus and German Recommendations

Author

Untch, Michael, additional, Ditsch, Nina, additional, Fasching, Peter A., additional, Busch, Steffi, additional, Ettl, Johannes, additional, Haidinger, Renate, additional, Harbeck, Nadia, additional, Jackisch, Christian, additional, Lüftner, Diana, additional, Müller, Lothar, additional, Ruckhäberle, Eugen, additional, Schumacher-Wulf, Eva, additional, Thomssen, Christoph, additional, Wuerstlein, Rachel, additional, and Müller, Volkmar, additional

Published
2024
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25. Adjuvant treatment with S-1 in patients after R0-resection of adenocarcinoma of the stomach and esophagogastric junction – A multicenter phase I/II feasibility study (GMBH-STO-0114)

Author

Heinrich, Kathrin, primary, Heinemann, Volker, additional, Stintzing, Sebastian, additional, Müller, Lothar, additional, Ettrich, Thomas J., additional, Buechner-Steudel, Petra, additional, Geißler, Michael, additional, Trojan, Jörg, additional, Moosmann, Nicolas, additional, Folprecht, Gunnar, additional, Schmidt, Johannes, additional, Kanzler, Stephan, additional, Kullmann, Frank, additional, Moulin, Jean-Charles, additional, Werner, Jens, additional, Angele, Martin K., additional, Probst, Victoria, additional, Held, Swantje, additional, Schulz, Christoph, additional, and Boukovala, Myrto, additional

Published
2024
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26. Supplementary Data 1 from Negative Hyperselection of Resistance Mutations for Panitumumab Maintenance in RAS Wild-Type Metastatic Colorectal Cancer (PanaMa Phase II Trial, AIO KRK 0212)

Author

Stahler, Arndt, primary, Kind, Andreas J., primary, Sers, Christine, primary, Mamlouk, Soulafa, primary, Müller, Lothar, primary, Karthaus, Meinolf, primary, Fruehauf, Stefan, primary, Graeven, Ullrich, primary, Fischer von Weikersthal, Ludwig, primary, Sommerhäuser, Greta, primary, Kasper, Stefan, primary, Hoppe, Beeke, primary, Kurreck, Annika, primary, Held, Swantje, primary, Heinemann, Volker, primary, Horst, David, primary, Jarosch, Armin, primary, Stintzing, Sebastian, primary, Trarbach, Tanja, primary, and Modest, Dominik P., primary

Published
2024
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27. Data from Negative Hyperselection of Resistance Mutations for Panitumumab Maintenance in RAS Wild-Type Metastatic Colorectal Cancer (PanaMa Phase II Trial, AIO KRK 0212)

Author

Stahler, Arndt, primary, Kind, Andreas J., primary, Sers, Christine, primary, Mamlouk, Soulafa, primary, Müller, Lothar, primary, Karthaus, Meinolf, primary, Fruehauf, Stefan, primary, Graeven, Ullrich, primary, Fischer von Weikersthal, Ludwig, primary, Sommerhäuser, Greta, primary, Kasper, Stefan, primary, Hoppe, Beeke, primary, Kurreck, Annika, primary, Held, Swantje, primary, Heinemann, Volker, primary, Horst, David, primary, Jarosch, Armin, primary, Stintzing, Sebastian, primary, Trarbach, Tanja, primary, and Modest, Dominik P., primary

Published
2024
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30. Negative hyperselection of resistance mutations for panitumumab maintenance in RAS wild-type metastatic colorectal cancer (PanaMa phase II trial, AIO KRK 0212).

Author

Stahler, Arndt, primary, Kind, Andreas J., additional, Sers, Christine, additional, Mamlouk, Soulafa, additional, Müller, Lothar, additional, Karthaus, Meinolf, additional, Frühauf, Stefan, additional, Graeven, Ullrich, additional, Fischer von Weikersthal, Ludwig, additional, Sommerhäuser, Greta, additional, Kasper, Stefan, additional, Hoppe, Beeke, additional, Kurreck, Annika, additional, Held, Swantje, additional, Heinemann, Volker, additional, Horst, David, additional, Jarosch, Armin, additional, Stintzing, Sebastian, additional, Trarbach, Tanja, additional, and Modest, Dominik P., additional

Published
2024
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31. Alternating application of gemcitabine/nab-paclitaxel (Gem/nab-Pac) and Gem monotherapy or continuous application of Gem/nab-Pac after induction treatment for first-line treatment of metastatic pancreatic cancer (mPC): First results from the randomized phase 2 ALPACA study from the German AIO study group (AIO-PAK-0114).

Author

Dorman, Klara, primary, Boeck, Stefan Hubert, additional, Caca, Karel, additional, Reichert, Maximilian, additional, Ettrich, Thomas Jens, additional, Oettle, Helmut, additional, Waidmann, Oliver, additional, Modest, Dominik Paul, additional, Müller, Lothar, additional, Michl, Patrick, additional, Kanzler, Stephan, additional, Pink, Daniel, additional, Reinacher-Schick, Anke C., additional, Geißler, Michael, additional, Pelz, Henning, additional, Kunzmann, Volker, additional, Held, Swantje, additional, Schichtl, Thomas, additional, Heinemann, Volker, additional, and Kullmann, Frank, additional

Published
2024
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32. Prediction of resistance to bevacizumab plus FOLFOX in metastatic colorectal cancer using a multi-marker panel and a machine-learning approach: Final results of the prospective multicenter PERMAD trial.

Author

Kestler, Hans A., primary, Ettrich, Thomas Jens, additional, Stein, Alexander, additional, Arnold, Dirk, additional, Prager, Gerald W., additional, Kasper, Stefan, additional, Niedermeier, Michael, additional, Müller, Lothar, additional, Kubicka, Stefan, additional, Koenig, Alexander, additional, Buechner-Steudel, Petra, additional, Berger, Andreas, additional, Wille, Kai, additional, Kestler, Angelika, additional, Kraus, Johann M., additional, Werle, Silke, additional, Perkhofer, Lukas, additional, Lausser, Ludwig, additional, and Seufferlein, Thomas, additional

Published
2024
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33. Prognostic model for newly diagnosed CLL patients in Binet stage A: results of the multicenter, prospective CLL1 trial of the German CLL study group

Author

Hoechstetter, Manuela A., Busch, Raymonde, Eichhorst, Barbara, Bühler, Andreas, Winkler, Dirk, Bahlo, Jasmin, Robrecht, Sandra, Eckart, Michael J., Vehling-Kaiser, Ursula, Jacobs, Georg, Jäger, Ulrich, Hurtz, Hans Jürgen, Hopfinger, Georg, Hartmann, Frank, Fuss, Harald, Abenhardt, Wolfgang, Blau, Ilona, Freier, Werner, Müller, Lothar, Goebeler, Maria, Wendtner, Clemens, Fischer, Kirsten, Herling, Carmen D., Starck, Michael, Bentz, Martin, Emmerich, Bertold, Döhner, Hartmut, Stilgenbauer, Stephan, and Hallek, Michael

Published
2020
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34. SWITCH II: Phase III randomized, sequential, open-label study to evaluate the efficacy and safety of sorafenib-pazopanib versus pazopanib-sorafenib in the treatment of advanced or metastatic renal cell carcinoma (AUO AN 33/11)

Author

Retz, Margitta, Bedke, Jens, Bögemann, Martin, Grimm, Marc-Oliver, Zimmermann, Uwe, Müller, Lothar, Leiber, Christian, Teber, Dogu, Wirth, Manfred, Bolenz, Christian, van Alphen, Robbert, De Santis, Maria, Beeker, Aart, Lehmann, Jan, Indorf, Martin, Frank, Melanie, Bokemeyer, Carsten, and Gschwend, Jürgen E.

Published
2019
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37. An Emerging Method of Rating Global Soil Quality and Productivity Potentials

Author

Mueller, Lothar, Schindler, Uwe, Hennings, Volker, Smolentseva, Elena N., Rukhovich, Olga V., Romanenkov, Vladimir A., Sychev, Victor G., Lukin, Sergey, Sheudshen, Askhad K., Onishenko, Ludmila, Saparov, Abdulla, Pachikin, Konstantin, Behrendt, Axel, Mirschel, Wilfried, Eulenstein, Frank, Mueller, Lothar, editor, Sheudshen, Askhad K., editor, and Eulenstein, Frank, editor

Published
2016
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39. Status Report About Understanding, Monitoring and Controlling Landscape Processes in Siberia

Author

Mueller, Lothar, Sheudshen, Askhad K., Sychev, Victor G., Syso, Aleksandr, Barsukov, Pavel, Smolentseva, Elena N., Siewert, Cristian, Meissner, Ralph, Dannowski, Ralf, Romanenkov, Vladimir A., Rukhovich, Olga V., Helming, Katharina, Schindler, Uwe, Eulenstein, Frank, Mueller, Lothar, editor, Sheudshen, Askhad K., editor, and Eulenstein, Frank, editor

Published
2016
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40. Land and Water Resources of Siberia, Their Functioning and Ecological State

Author

Mueller, Lothar, Sheudshen, Askhad K., Syso, Aleksandr, Barsukov, Pavel, Smolentseva, Elena N., Khodzher, Tamara, Sychev, Victor G., Romanenkov, Vladimir A., Rukhovich, Olga V., Puzanov, Aleksandr, Dannowski, Ralf, Schindler, Uwe, Eulenstein, Frank, Mueller, Lothar, editor, Sheudshen, Askhad K., editor, and Eulenstein, Frank, editor

Published
2016
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41. Prediction of resistance to bevacizumab plus FOLFOX in metastatic colorectal cancer—Results of the prospective multicenter PERMAD trial.

Author

Seufferlein, Thomas, Lausser, Ludwig, Stein, Alexander, Arnold, Dirk, Prager, Gerald, Kasper-Virchow, Stefan, Niedermeier, Michael, Müller, Lothar, Kubicka, Stefan, König, Alexander, Büchner-Steudel, Petra, Wille, Kai, Berger, Andreas W., Kestler, Angelika M. R., Kraus, Johann M., Werle, Silke D., Perkhofer, Lukas, Ettrich, Thomas J., and Kestler, Hans A.

Subjects
BEVACIZUMAB, MACHINE learning, COLORECTAL cancer, ANTINEOPLASTIC combined chemotherapy protocols, ENDOTHELIAL growth factors, METASTASIS
Abstract

Background: Anti-vascular endothelial growth factor (VEGF) monoclonal antibodies (mAbs) are widely used for tumor treatment, including metastatic colorectal cancer (mCRC). So far, there are no biomarkers that reliably predict resistance to anti-VEGF mAbs like bevacizumab. A biomarker-guided strategy for early and accurate assessment of resistance could avoid the use of non-effective treatment and improve patient outcomes. We hypothesized that repeated analysis of multiple cytokines and angiogenic growth factors (CAFs) before and during treatment using machine learning could provide an accurate and earlier, i.e., 100 days before conventional radiologic staging, prediction of resistance to first-line mCRC treatment with FOLFOX plus bevacizumab. Patients and methods: 15 German and Austrian centers prospectively recruited 50 mCRC patients receiving FOLFOX plus bevacizumab as first-line treatment. Plasma samples were collected every two weeks until radiologic progression (RECIST 1.1) as determined by CT scans performed every 2 months. 102 pre-selected CAFs were centrally analyzed using a cytokine multiplex assay (Luminex, Myriad RBM). Results: Using random forests, we developed a predictive machine learning model that discriminated between the situations of "no progress within 100 days before radiological progress" and "progress within 100 days before radiological progress". We could further identify a combination of ten out of the 102 CAF markers, which fulfilled this task with 78.2% accuracy, 71.8% sensitivity, and 82.5% specificity. Conclusions: We identified a CAF marker combination that indicates treatment resistance to FOLFOX plus bevacizumab in patients with mCRC within 100 days prior to radiologic progress. [ABSTRACT FROM AUTHOR]

Published
2024
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42. Bendamustine, followed by obinutuzumab and idelalisib in chronic lymphocytic leukemia (CLL2‐BCG): Final analysis of a multicenter, open‐label phase‐II‐trial.

Author

Cramer, Paula, von Tresckow, Julia, Fink, Anna‐Maria, Robrecht, Sandra, Giza, Adam, Tausch, Eugen, Müller, Lothar, Knauf, Wolfgang, Zingerle, Matthias, Al‐Sawaf, Othman, Langerbeins, Petra, Fischer, Kirsten, Kreuzer, Karl‐Anton, Kneba, Michael, Wendtner, Clemens‐Martin, Stilgenbauer, Stephan, Eichhorst, Barbara, and Hallek, Michael

Published
2024
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45. Immunotherapeutic maintenance treatment with toll-like receptor 9 agonist lefitolimod in patients with extensive-stage small-cell lung cancer: results from the exploratory, controlled, randomized, international phase II IMPULSE study

Author

Pall, Georg, Surmont, Veerle, Bosquee, Léon, Germonpré, Paul, Brückl, Wolfgang, Grah, Christina, Herzmann, Christian, Leistner, Rumo, Meyer, Andreas, Müller, Lothar, Schmalz, Oliver, Scholz, Christian, Schröder, Michael, Serke, Monika, Wesseler, Claas, Brandts, Christian, Kopp, Hans-Georg, Blau, Wolfgang, Griesinger, Frank, Campelo, Maria Rosario Garcia, Garcia, Yolanda Garcia, Perez, José Manuel Trigo, Thomas, M., Ponce-Aix, S., Navarro, A., Riera-Knorrenschild, J., Schmidt, M., Wiegert, E., Kapp, K., Wittig, B., Mauri, C., Dómine Gómez, M., Kollmeier, J., Sadjadian, P., Fröhling, K -P, Huber, R.M., and Wolf, M.

Published
2018
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48. S200: IBRUTINIB VERSUS PLACEBO IN PATIENTS WITH ASYMPTOMATIC, TREATMENT-NAÏVE EARLY STAGE CHRONIC LYMPHOCYTIC LEUKEMIA (CLL): FINAL RESULTS OF THE PHASE 3, DOUBLE-BLIND, PLACEBO-CONTROLLED CLL12 TRIAL

Author

Langerbeins, Petra, primary, Robrecht, Sandra, additional, Nieper, Pascal, additional, Cramer, Paula, additional, Fürstenau, Moritz, additional, Al-Sawaf, Othman, additional, Fink, Anna-Maria, additional, Kreuzer, Karl-Anton, additional, Vehling-Kaiser, Ursula, additional, Tausch, Eugen, additional, Schneider, Christof, additional, Müller, Lothar, additional, Eckart, Michael, additional, Schlag, Rudolf, additional, Freier, Werner, additional, Gaska, Tobias, additional, Balser, Christina, additional, Reiser, Marcel, additional, Stauch, Martina, additional, Wendtner, Clemens, additional, Fischer, Kirsten, additional, Stilgenbauer, Stephan, additional, Eichhorst, Barbara, additional, and Hallek, Michael, additional

Published
2023
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49. Executive Summary and Conclusions

Author

Mueller, Lothar, Saparov, Abdulla, Lischeid, Gunnar, Förstner, Ulrich, Series editor, Salomons, W., Series editor, Mueller, Lothar, editor, Saparov, Abdulla, editor, and Lischeid, Gunnar, editor

Published
2014
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50. Multi-Species Grazing on Deer Farms

Author

Behrendt, Axel, Fischer, Andreas, Kaiser, Thomas, Eulenstein, Frank, Ortmann, Sylvia, Berger, Anne, Mueller, Lothar, Förstner, Ulrich, Series editor, Salomons, W., Series editor, Mueller, Lothar, editor, Saparov, Abdulla, editor, and Lischeid, Gunnar, editor

Published
2014
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