16 results on '"Mühlberg, Christoph"'
Search Results
2. A Specific Pattern of Routine Cerebrospinal Fluid Parameters Might Help to Identify Cases of West Nile Virus Neuroinvasive Disease.
- Author
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Pelz, Johann Otto, Mühlberg, Christoph, Friedrich, Isabel, Weidhase, Lorenz, Zimmermann, Silke, Maier, Melanie, and Pietsch, Corinna
- Subjects
- *
WEST Nile fever , *CEREBROSPINAL fluid , *CEREBROSPINAL fluid examination , *WEST Nile virus , *IMMUNOGLOBULIN M , *VIRUS diseases - Abstract
Background: Viral meningitis/encephalitis (ME) is a rare but potentially harmful disease. The prompt identification of the respective virus is important to guide not only treatment but also potential public health countermeasures. However, in about 40% of cases, no virus is identified despite an extensive diagnostic workup. The aim of the present study was to analyze demographic, seasonal, and routine cerebrospinal fluid (CSF) parameters in cases of viral ME and assess their utility for the prediction of the causative virus. Methods: Demographic data, season, and routine CSF parameters (total leucocytes, CSF cell differentiation, age-adjusted CSF/serum albumin ratio, and total immunoglobulin ratios) were retrospectively assessed in cases of viral ME. Results: In total, 156 cases of acute viral ME (74 female, median age 40.0 years) were treated at a tertiary-care hospital in Germany. Specific viral infections were detected in 93 (59.6%) cases. Of these, 14 (9.0%) cases were caused by herpes simplex virus (HSV), 36 (23.1%) by varicella-zoster virus (VZV), 27 (17.3%) by enteroviruses, 9 (5.8%) by West Nile virus (WNV), and 7 (4.5%) by other specific viruses. Additionally, 64 (41.0%) cases of ME of unknown viral etiology were diagnosed. Cases of WNV ME were older, predominantly male, showed a severe disruption of the blood–CSF–barrier, a high proportion of neutrophils in CSF, and an intrathecal total immunoglobulin M synthesis in the first CSF sample. In a multinominal logistic regression analysis, the accuracy of these CSF parameters together with age and seasonality was best for the prediction of WNV (87.5%), followed by unknown viral etiology (66.7%), VZV (61.8%), and enteroviruses (51.9%). Conclusions: Cases with WNV ME showed a specific pattern of routine CSF parameters and demographic data that allowed for their identification with good accuracy. These findings might help to guide the diagnostic workup in cases with viral ME, in particular allowing the timely identification of cases with ME due to WNV. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
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3. Stopping at the sight of food – How gender and obesity impact on response inhibition
- Author
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Mühlberg, Christoph, Mathar, David, Villringer, Arno, Horstmann, Annette, and Neumann, Jane
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- 2016
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4. SWOT analysis and strategy development for forest fuel supply chains in South East Europe
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Rauch, Peter, Wolfsmayr, Ulrich J., Borz, Stelian Alexandru, Triplat, Matevž, Krajnc, Nike, Kolck, Matthias, Oberwimmer, Roland, Ketikidis, Chrysovalantis, Vasiljevic, Aleksandar, Stauder, Michael, Mühlberg, Christoph, Derczeni, Rudolf, Oravec, Milan, Krissakova, Ingrid, and Handlos, Maximilian
- Published
- 2015
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5. Visuomotor Adaptation Deficits in Patients with Essential Tremor
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Bindel, Laura, primary, Mühlberg, Christoph, additional, Pfeiffer, Victoria, additional, Nitschke, Matthias, additional, Müller, Annekatrin, additional, Wegscheider, Mirko, additional, Rumpf, Jost-Julian, additional, Zeuner, Kirsten E., additional, Becktepe, Jos S., additional, Welzel, Julius, additional, Güthe, Miriam, additional, Classen, Joseph, additional, and Tzvi, Elinor, additional
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- 2022
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6. Cross-frequency phase-amplitude coupling in repetitive movements in patients with Parkinson's disease
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Gong, Ruxue, primary, Mühlberg, Christoph, additional, Wegscheider, Mirko, additional, Fricke, Christopher, additional, Rumpf, Jost-Julian, additional, Knösche, Thomas R., additional, and Classen, Joseph, additional
- Published
- 2022
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7. Cross-frequency phase-amplitude coupling in repetitive movements in patients with Parkinson’s disease
- Author
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Gong, Ruxue, primary, Mühlberg, Christoph, additional, Wegscheider, Mirko, additional, Fricke, Christopher, additional, Rumpf, Jost-Julian, additional, Knösche, Thomas R., additional, and Classen, Joseph, additional
- Published
- 2021
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8. Cross-frequency phase-amplitude coupling in repetitive movements in patients with Parkinson'sdisease.
- Author
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Ruxue Gong, Mühlberg, Christoph, Wegscheider, Mirko, Fricke, Christopher, Rumpf, Jost-Julian, Knösche, Thomas R., and Classen, Joseph
- Subjects
- *
PARKINSON'S disease , *SOMATOSENSORY cortex , *MOVEMENT disorders , *POPULATION dynamics , *HYPOKINESIA - Abstract
Bradykinesia is a cardinal motor symptom in Parkinson's disease (PD), the pathophysiology of which is not fully understood. We analyzed the role of cross-frequency coupling of oscillatory cortical activity in motor impairment in patients with PD and healthy controls. High-density EEG signals were recorded during various motor activities and at rest. Patients performed a repetitive finger-pressing task normally, but were slower than controls during tapping. Phase-amplitude coupling (PAC) between b (13-30 Hz) and broadband c (50-150 Hz) was computed from individual EEG source signals in the premotor, primary motor, and primary somatosensory cortices, and the primary somatosensory complex. In all four regions, averaging the entire movement period resulted in higher PAC in patients than in controls for the resting condition and the pressing task (similar performance between groups). However, this was not the case for the tapping tasks where patients performed slower. This suggests the strength of state-related b-c PAC does not determine Parkinsonian bradykinesia. Examination of the dynamics of oscillatory EEG signals during motor transitions revealed a distinctive motif of PAC rise and decay around press onset. This pattern was also present at press offset and slow tapping onset, linking such idiosyncratic PAC changes to transitions between different movement states. The transition-related PAC modulation in patients was similar to controls in the pressing task but flattened during slow tapping, which related to normal and abnormal performance, respectively. These findings suggest that the dysfunctional evolution of neuronal population dynamics during movement execution is an important component of the pathophysiology of Parkinsonian bradykinesia. NEW & NOTEWORTHY Our findings using noninvasive EEG recordings provide evidence that PAC dynamics might play a role in the physiological cortical control of movement execution and may encode transitions between movement states. Results in patients with Parkinson's disease suggest that bradykinesia is related to a deficit of the dynamic regulation of PAC during movement execution rather than its absolute strength. Our findings may contribute to the development of a new concept of the pathophysiology of bradykinesia. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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9. Spatiotemporal features of β-γ phase-amplitude coupling in Parkinson’s disease derived from scalp EEG
- Author
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Gong, Ruxue, primary, Wegscheider, Mirko, additional, Mühlberg, Christoph, additional, Gast, Richard, additional, Fricke, Christopher, additional, Rumpf, Jost-Julian, additional, Nikulin, Vadim V, additional, Knösche, Thomas R, additional, and Classen, Joseph, additional
- Published
- 2020
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10. Spatiotemporal features of β-γ phase-amplitude coupling in Parkinson's disease derived from scalp EEG.
- Author
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Gong, Ruxue, Wegscheider, Mirko, Mühlberg, Christoph, Gast, Richard, Fricke, Christopher, Rumpf, Jost-Julian, Nikulin, Vadim V, Knösche, Thomas R, and Classen, Joseph
- Subjects
PARKINSON'S disease ,INDEPENDENT component analysis ,DOMAIN specificity ,PREMOTOR cortex ,SUBTHALAMIC nucleus ,RESEARCH ,ELECTROENCEPHALOGRAPHY ,NEURAL pathways ,SCALP ,RESEARCH methodology ,MEDICAL cooperation ,EVALUATION research ,COMPARATIVE studies ,SIGNAL processing ,CEREBRAL cortex - Abstract
Abnormal phase-amplitude coupling between β and broadband-γ activities has been identified in recordings from the cortex or scalp of patients with Parkinson's disease. While enhanced phase-amplitude coupling has been proposed as a biomarker of Parkinson's disease, the neuronal mechanisms underlying the abnormal coupling and its relationship to motor impairments in Parkinson's disease remain unclear. To address these issues, we performed an in-depth analysis of high-density EEG recordings at rest in 19 patients with Parkinson's disease and 20 age- and sex-matched healthy control subjects. EEG signals were projected onto the individual cortical surfaces using source reconstruction techniques and separated into spatiotemporal components using independent component analysis. Compared to healthy controls, phase-amplitude coupling of Parkinson's disease patients was enhanced in dorsolateral prefrontal cortex, premotor cortex, primary motor cortex and somatosensory cortex, the difference being statistically significant in the hemisphere contralateral to the clinically more affected side. β and γ signals involved in generating abnormal phase-amplitude coupling were not strictly phase-phase coupled, ruling out that phase-amplitude coupling merely reflects the abnormal activity of a single oscillator in a recurrent network. We found important differences for couplings between the β and γ signals from identical components as opposed to those from different components (originating from distinct spatial locations). While both couplings were abnormally enhanced in patients, only the latter were correlated with clinical motor severity as indexed by part III of the Movement Disorder Society Unified Parkinson's Disease Rating Scale. Correlations with parkinsonian motor symptoms of such inter-component couplings were found in premotor, primary motor and somatosensory cortex, but not in dorsolateral prefrontal cortex, suggesting motor domain specificity. The topography of phase-amplitude coupling demonstrated profound differences in patients compared to controls. These findings suggest, first, that enhanced phase-amplitude coupling in Parkinson's disease patients originates from the coupling between distinct neural networks in several brain regions involved in motor control. Because these regions included the somatosensory cortex, abnormal phase-amplitude coupling is not exclusively tied to the hyperdirect tract connecting cortical regions monosynaptically with the subthalamic nucleus. Second, only the coupling between β and γ signals from different components appears to have pathophysiological significance, suggesting that therapeutic approaches breaking the abnormal lateral coupling between neuronal circuits may be more promising than targeting phase-amplitude coupling per se. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
11. Der Einfluss der Faktoren Geschlecht und Adipositas auf die inhibitorische Kontrolle
- Author
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Mühlberg, Christoph and Universität Leipzig
- Subjects
inhibitorische Kontrolle, Adipositas, Stop Signal task, Geschlechtsunterschiede ,ddc:610 - Abstract
Bisherige Untersuchungen deuten darauf hin, dass ein höherer BMI mit einer reduzierten inhibitorischen Kontrolle verbunden sei. Allerdings sind die bisherigen Ergebnisse zum Teil widersprüchlich und die Untersuchungen erfolgten hauptsächlich bei weiblichen Versuchspersonen. Ich untersuchte gezielt die inhibitorische Kontrolle innerhalb und außerhalb des Essenskontextes bei Männern und Frauen unterschiedlichen Gewichtes. Außerdem erfolgte eine Bewertung von unterschiedlichen Essensbildern nach deren Schmackhaftigkeit und die Erhebung von Verhaltensmerkmalen zum Essverhalten und der Impulsivität mittels Fragebögen. Ich konnte zeigen, dass Frauen niedrigkalorische Nahrungsmittel schmackhafter bewerteten als Männer. Außerdem hatten Frauen eine bessere inhibitorische Kontrolle nach der Ansicht von hochkalorischen Nahrungsmittel im Vergleich zu niedrigkalorischen Nahrungsmitteln. Es gab einen statistischen Trend für eine bessere inhibitorische Kontrolle nach der Ansicht von hochkalorischen Nahrungsmitteln bei Frauen gegenüber Männern. Es konnte kein direkter Zusammenhang zwischen Gewicht und inhibitorischer Kontrolle sowohl innerhalb als auch außerhalb des Essenskontextes gefunden werden. Allerdings konnte ich zeigen, dass es einen Moderationseffekt der Merkmalsimpulsivität auf den Zusammenhang zwischen inhibitorischer Kontrolle und BMI für den hochkalorischen Essenskontext gab. Dies deutet auf einen komplexen Zusammenhang zwischen Merkmalsimpulsivität, BMI und inhibitorischer Kontrolle hin. Mit meinen Ergebnissen konnte ich zeigen, dass adipöse Personen nicht an einer verminderten inhibitorischen Kontrolle per se leiden. Die Unterdrückung einer unerwünschten Handlung scheint vielmehr von sozialen Normen und dem aktuellen Kontext abzuhängen. Zusätzlich interagieren Faktoren wie Geschlecht und Merkmalsimpulsivität mit der inhibitorischen Kontrolle. Recent research indicates that reduced inhibitory control is associated with higher body mass index (BMI), higher food craving and increased food intake. However, experimental evidence for the relationship between response inhibition and weight status is inconsistent and to date has been investigated predominantly in women. In the current study, 56 participants (26 obese, 30 lean; 27 female, 29 male)performed a Food Picture Rating Task followed by a Stop Signal Task where pictures of palatable high or low caloric food or non-food items were presented prior to the Go signal. We further assessed participants’ self-reported eating behavior and trait impulsivity as potential factors influencing response inhibition, in particular within the food context. Independent of BMI, women showed significantly higher liking for low caloric food items than men. This was accompanied by shorter Stop Signal Reaction Times (SSRT) after high compared to low caloric food pictures for women, and shorter SSRT in women compared to men for high caloric food. No influence of gender on SSRT was observable outside of the food context. While SSRTs did not differ between obese and lean participants across the three Picture categories, we found a moderating effect of trait impulsivity on the relationship between BMI and SSRT, specifically in the high caloric food context. Higher BMI was predictive of longer SSRT only for participants with low to normal trait impulsivity, pointing at a complex interplay between response inhibition, general impulsivity and weight status. Our results support the notion that individuals with obesity do not suffer from diminished response inhibition capacity per se. Rather, the ability to withhold a Response depends on context and social norms, and strongly interacts with factors like gender and trait impulsivity.
- Published
- 2017
12. IN2WOOD Joint Action Plan
- Author
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Kies, Uwe, Oberwimmer, Roland, Mühlberg, Christoph, and Marie-Charlotte Hoffmann
- Published
- 2011
- Full Text
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13. SWOT strategies for forestry logistics in six European regions
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Kovalčík, Miroslav, primary, Mühlberg, Christoph, additional, Oberwimmer, Roland, additional, Pretterhofer, Erhard, additional, Felix, Christian, additional, Gabathuler, Michael, additional, Holtkämper, Volker, additional, Kies, Uwe, additional, Soloviy, Ihor, additional, and Pahl, Iris, additional
- Published
- 2013
- Full Text
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14. Is the Deutsche Forschungsgemeinschaft a ‘Buffer Institution’ for Research in Germany?
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Mühlberg, Christoph, primary
- Published
- 1992
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15. Is the Deutsche Forschungsgemeinschafta ‘Buffer Institution’ for Research in Germany?
- Author
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Mühlberg, Christoph
- Abstract
It seems that one can consider the Deutsche Forschungsgemeinschaft(DFG) as an intermediary organization between the State and science just like any other research council or institution of higher education which is not part of the government and fulfils its role with a certain degree of autonomy. This view, however, is problematic, and even more so if one asks whether the DFG is a buffer institution. The key notion of a ‘buffer’ is its situation ‘between’ two units or elements along with a shock-absorbing effect. DFG however, is not situated ‘between’ the State and science. As a body of scientific self-governance it is part of the sphere of science and research itself. DFG is an association under private law with a membership mainly of universities and, for about one-third, of other research institutions. It has a statute, not a charter. It is neither created by parliament or government, nor by a decree, nor by an act of law. The financial and allocative responsibilities it exercises are not delegated by the State. It certainly does not act on behalf of the State. Its representatives are elected by the members of the association, not appointed or confirmed by any public authority. The main role of the DFG is to allocate money for projects carried out in research institutions – mainly, but not necessarily, its member institutions. The money comes mostly from public sources in the form of a grant negotiated each year by and with the funding authorities, the Federal and Regional States, on a contractual basis. With this mode of funding, these authorities further the particular way in which the DFG serves the freedom and autonomy of science laid down in the German constitution. They provide a supplement to their own forms of direct or delegated funding of research in recognition of the fact that in the sphere of basic research, allocation of funds is best taken care of under the responsibility of scientists themselves.
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- 1992
- Full Text
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16. Spatiotemporal features of β-γ phase-amplitude coupling in Parkinson's disease derived from scalp EEG.
- Author
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Gong R, Wegscheider M, Mühlberg C, Gast R, Fricke C, Rumpf JJ, Nikulin VV, Knösche TR, and Classen J
- Subjects
- Adult, Aged, Electroencephalography methods, Female, Humans, Male, Middle Aged, Neural Pathways physiopathology, Scalp, Signal Processing, Computer-Assisted, Beta Rhythm, Cerebral Cortex physiopathology, Gamma Rhythm, Parkinson Disease physiopathology
- Abstract
Abnormal phase-amplitude coupling between β and broadband-γ activities has been identified in recordings from the cortex or scalp of patients with Parkinson's disease. While enhanced phase-amplitude coupling has been proposed as a biomarker of Parkinson's disease, the neuronal mechanisms underlying the abnormal coupling and its relationship to motor impairments in Parkinson's disease remain unclear. To address these issues, we performed an in-depth analysis of high-density EEG recordings at rest in 19 patients with Parkinson's disease and 20 age- and sex-matched healthy control subjects. EEG signals were projected onto the individual cortical surfaces using source reconstruction techniques and separated into spatiotemporal components using independent component analysis. Compared to healthy controls, phase-amplitude coupling of Parkinson's disease patients was enhanced in dorsolateral prefrontal cortex, premotor cortex, primary motor cortex and somatosensory cortex, the difference being statistically significant in the hemisphere contralateral to the clinically more affected side. β and γ signals involved in generating abnormal phase-amplitude coupling were not strictly phase-phase coupled, ruling out that phase-amplitude coupling merely reflects the abnormal activity of a single oscillator in a recurrent network. We found important differences for couplings between the β and γ signals from identical components as opposed to those from different components (originating from distinct spatial locations). While both couplings were abnormally enhanced in patients, only the latter were correlated with clinical motor severity as indexed by part III of the Movement Disorder Society Unified Parkinson's Disease Rating Scale. Correlations with parkinsonian motor symptoms of such inter-component couplings were found in premotor, primary motor and somatosensory cortex, but not in dorsolateral prefrontal cortex, suggesting motor domain specificity. The topography of phase-amplitude coupling demonstrated profound differences in patients compared to controls. These findings suggest, first, that enhanced phase-amplitude coupling in Parkinson's disease patients originates from the coupling between distinct neural networks in several brain regions involved in motor control. Because these regions included the somatosensory cortex, abnormal phase-amplitude coupling is not exclusively tied to the hyperdirect tract connecting cortical regions monosynaptically with the subthalamic nucleus. Second, only the coupling between β and γ signals from different components appears to have pathophysiological significance, suggesting that therapeutic approaches breaking the abnormal lateral coupling between neuronal circuits may be more promising than targeting phase-amplitude coupling per se., (© The Author(s) (2020). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
- Published
- 2021
- Full Text
- View/download PDF
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