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14 results on '"Müezzinler, Aysel"'

1. Impact of smoking and smoking cessation on cardiovascular events and mortality among older adults : meta-analysis of individual participant data from prospective cohort studies of the CHANCES consortium

Author

CHANCES consortium, Mons, Ute, Müezzinler, Aysel, Gellert, Carolin, Schöttker, Ben, Abnet, Christian C, Bobak, Martin, de Groot, Lisette, Freedman, Neal D, Jansen, Eugène, Kee, Frank, Kromhout, Daan, Kuulasmaa, Kari, Laatikainen, Tiina, O’Doherty, Mark G, Bueno-de-Mesquita, Bas, Orfanos, Philippos, Peters, Annette, van der Schouw, Yvonne T, Wilsgaard, Tom, Wolk, Alicja, Trichopoulou, Antonia, Boffetta, Paolo, and Brenner, Hermann

Published
2015

2. Repeated measures of body mass index and C-reactive protein in relation to all-cause mortality and cardiovascular disease: results from the consortium on health and ageing network of cohorts in Europe and the United States (CHANCES)

Author

O'Doherty, Mark G., Jørgensen, Torben, Borglykke, Anders, Brenner, Hermann, Schöttker, Ben, Wilsgaard, Tom, Siganos, Galatios, Kavousi, Maryam, Hughes, Maria, Müezzinler, Aysel, Holleczek, Bernd, Franco, Oscar H., Hofman, Albert, Boffetta, Paolo, Trichopoulou, Antonia, and Kee, Frank

Published
2014

3. Repeated measures of body mass index and C-reactive protein in relation to all-cause mortality and cardiovascular disease: results from the consortium on health and ageing network of cohorts in Europe and the United States (CHANCES)

Author

O’Doherty, Mark G., Jørgensen, Torben, Borglykke, Anders, Brenner, Hermann, Schöttker, Ben, Wilsgaard, Tom, Siganos, Galatios, Kavousi, Maryam, Hughes, Maria, Müezzinler, Aysel, Holleczek, Bernd, Franco, Oscar H., Hofman, Albert, Boffetta, Paolo, Trichopoulou, Antonia, and Kee, Frank

Published
2014
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6. Impact of smoking and smoking cessation on cardiovascular events and mortality among older adults: meta-analysis of individual participant data from prospective cohort studies of the CHANCES consortium

Author

Mons, Ute, Müezzinler, Aysel, Gellert, Carolin, Schöttker, Ben, Abnet, Christian C, Bobak, Martin, de Groot, Lisette, Freedman, Neal D, Jansen, Eugène, Kee, Frank, Kromhout, Daan, Kuulasmaa, Kari, Laatikainen, Tiina, OʼDoherty, Mark G, Bueno-de-Mesquita, Bas, Orfanos, Philippos, Peters, Annette, van der Schouw, Yvonne T, Wilsgaard, Tom, Wolk, Alicja, Trichopoulou, Antonia, Boffetta, Paolo, and Brenner, Hermann

Published
2015
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8. Leukocyte Telomere Length and All-Cause, Cardiovascular Disease, and Cancer Mortality: Results From Individual-Participant-Data Meta-Analysis of 2 Large Prospective Cohort Studies

Author

Mons, Ute, primary, Müezzinler, Aysel, additional, Schöttker, Ben, additional, Dieffenbach, Aida Karina, additional, Butterbach, Katja, additional, Schick, Matthias, additional, Peasey, Anne, additional, De Vivo, Immaculata, additional, Trichopoulou, Antonia, additional, Boffetta, Paolo, additional, and Brenner, Hermann, additional

Published
2017
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10. Smoking and All-cause Mortality in Older Adults : Results From the CHANCES Consortium.

Author

Müezzinler, Aysel, Mons, Ute, Gellert, Carolin, Schöttker, Ben, Jansen, Eugène, Kee, Frank, O'Doherty, Mark G, Kuulasmaa, Kari, Freedman, Neal D, Abnet, Christian C, Wolk, Alicja, Håkansson, Niclas, Orsini, Nicola, Wilsgaard, Tom, Bueno-de-Mesquita, Bas, van der Schouw, Yvonne T, Peeters, Petra H M, de Groot, Lisette C P G M, Peters, Annette, Orfanos, Philippos, Linneberg, Allan, Pisinger, Charlotta, Tamosiunas, Abdonas, Baceviciene, Migle, Luksiene, Dalia, Bernotiene, Gailute, Jousilahti, Pekka, Petterson-Kymmer, Ulrika, Jansson, Jan Håkan, Söderberg, Stefan, Eriksson, Sture, Jankovic, Nicole, Sánchez, María-José, Veronesi, Giovanni, Sans, Susana, Drygas, Wojciech, Trichopoulou, Antonia, Boffetta, Paolo, Brenner, Hermann, Müezzinler, Aysel, Mons, Ute, Gellert, Carolin, Schöttker, Ben, Jansen, Eugène, Kee, Frank, O'Doherty, Mark G, Kuulasmaa, Kari, Freedman, Neal D, Abnet, Christian C, Wolk, Alicja, Håkansson, Niclas, Orsini, Nicola, Wilsgaard, Tom, Bueno-de-Mesquita, Bas, van der Schouw, Yvonne T, Peeters, Petra H M, de Groot, Lisette C P G M, Peters, Annette, Orfanos, Philippos, Linneberg, Allan, Pisinger, Charlotta, Tamosiunas, Abdonas, Baceviciene, Migle, Luksiene, Dalia, Bernotiene, Gailute, Jousilahti, Pekka, Petterson-Kymmer, Ulrika, Jansson, Jan Håkan, Söderberg, Stefan, Eriksson, Sture, Jankovic, Nicole, Sánchez, María-José, Veronesi, Giovanni, Sans, Susana, Drygas, Wojciech, Trichopoulou, Antonia, Boffetta, Paolo, and Brenner, Hermann

Abstract

INTRODUCTION: Smoking is known to be a major cause of death among middle-aged adults, but evidence on its impact and the benefits of smoking cessation among older adults has remained limited. Therefore, we aimed to estimate the influence of smoking and smoking cessation on all-cause mortality in people aged ≥60 years. METHODS: Relative mortality and mortality rate advancement periods (RAPs) were estimated by Cox proportional hazards models for the population-based prospective cohort studies from Europe and the U.S. (CHANCES [Consortium on Health and Ageing: Network of Cohorts in Europe and the U.S.]), and subsequently pooled by individual participant meta-analysis. Statistical analyses were performed from June 2013 to March 2014. RESULTS: A total of 489,056 participants aged ≥60 years at baseline from 22 population-based cohort studies were included. Overall, 99,298 deaths were recorded. Current smokers had 2-fold and former smokers had 1.3-fold increased mortality compared with never smokers. These increases in mortality translated to RAPs of 6.4 (95% CI=4.8, 7.9) and 2.4 (95% CI=1.5, 3.4) years, respectively. A clear positive dose-response relationship was observed between number of currently smoked cigarettes and mortality. For former smokers, excess mortality and RAPs decreased with time since cessation, with RAPs of 3.9 (95% CI=3.0, 4.7), 2.7 (95% CI=1.8, 3.6), and 0.7 (95% CI=0.2, 1.1) for those who had quit <10, 10 to 19, and ≥20 years ago, respectively. CONCLUSIONS: Smoking remains as a strong risk factor for premature mortality in older individuals and cessation remains beneficial even at advanced ages. Efforts to support smoking abstinence at all ages should be a public health priority.

Published
2015
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11. Smoking and All-cause Mortality in Older Adults: Results From the CHANCES Consortium

Author

MS MDL 1, Cancer, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Circulatory Health, Cardiovasculaire Epidemiologie, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Müezzinler, Aysel, Mons, Ute, Gellert, Carolin, Schöttker, Ben, Jansen, Eugène, Kee, Frank, O'Doherty, Mark G., Kuulasmaa, Kari, Freedman, Neal D., Abnet, Christian C., Wolk, Alicja, Håkansson, Niclas, Orsini, Nicola, Wilsgaard, Tom, Bueno-De-Mesquita, Bas, Van Der Schouw, Yvonne T., Peeters, Petra H M, De Groot, Lisette C P G M, Peters, Annette, Orfanos, Philippos, Linneberg, Allan, Pisinger, Charlotta, Tamosiunas, Abdonas, Baceviciene, Migle, Luksiene, Dalia, Bernotiene, Gailute, Jousilahti, Pekka, Petterson-Kymmer, Ulrika, Jansson, Jan Håkan, Söderberg, Stefan, Eriksson, Sture, Jankovic, Nicole, Sánchez, María José, Veronesi, Giovanni, Sans, Susana, Drygas, Wojciech, Trichopoulou, Antonia, Boffetta, Paolo, Brenner, Hermann, MS MDL 1, Cancer, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Circulatory Health, Cardiovasculaire Epidemiologie, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Müezzinler, Aysel, Mons, Ute, Gellert, Carolin, Schöttker, Ben, Jansen, Eugène, Kee, Frank, O'Doherty, Mark G., Kuulasmaa, Kari, Freedman, Neal D., Abnet, Christian C., Wolk, Alicja, Håkansson, Niclas, Orsini, Nicola, Wilsgaard, Tom, Bueno-De-Mesquita, Bas, Van Der Schouw, Yvonne T., Peeters, Petra H M, De Groot, Lisette C P G M, Peters, Annette, Orfanos, Philippos, Linneberg, Allan, Pisinger, Charlotta, Tamosiunas, Abdonas, Baceviciene, Migle, Luksiene, Dalia, Bernotiene, Gailute, Jousilahti, Pekka, Petterson-Kymmer, Ulrika, Jansson, Jan Håkan, Söderberg, Stefan, Eriksson, Sture, Jankovic, Nicole, Sánchez, María José, Veronesi, Giovanni, Sans, Susana, Drygas, Wojciech, Trichopoulou, Antonia, Boffetta, Paolo, and Brenner, Hermann

Published
2015

12. Smoking and All-cause Mortality in Older Adults:Results From the CHANCES Consortium

Author

Müezzinler, Aysel, Mons, Ute, Gellert, Carolin, Schöttker, Ben, Jansen, Eugène, Kee, Frank, O'Doherty, Mark G, Kuulasmaa, Kari, Freedman, Neal D, Abnet, Christian C, Wolk, Alicja, Håkansson, Niclas, Orsini, Nicola, Wilsgaard, Tom, Bueno-de-Mesquita, Bas, van der Schouw, Yvonne T, Peeters, Petra H M, de Groot, Lisette C P G M, Peters, Annette, Orfanos, Philippos, Linneberg, Allan, Pisinger, Charlotta, Tamosiunas, Abdonas, Baceviciene, Migle, Luksiene, Dalia, Bernotiene, Gailute, Jousilahti, Pekka, Petterson-Kymmer, Ulrika, Jansson, Jan Håkan, Söderberg, Stefan, Eriksson, Sture, Jankovic, Nicole, Sánchez, María-José, Veronesi, Giovanni, Sans, Susana, Drygas, Wojciech, Trichopoulou, Antonia, Boffetta, Paolo, Brenner, Hermann, Müezzinler, Aysel, Mons, Ute, Gellert, Carolin, Schöttker, Ben, Jansen, Eugène, Kee, Frank, O'Doherty, Mark G, Kuulasmaa, Kari, Freedman, Neal D, Abnet, Christian C, Wolk, Alicja, Håkansson, Niclas, Orsini, Nicola, Wilsgaard, Tom, Bueno-de-Mesquita, Bas, van der Schouw, Yvonne T, Peeters, Petra H M, de Groot, Lisette C P G M, Peters, Annette, Orfanos, Philippos, Linneberg, Allan, Pisinger, Charlotta, Tamosiunas, Abdonas, Baceviciene, Migle, Luksiene, Dalia, Bernotiene, Gailute, Jousilahti, Pekka, Petterson-Kymmer, Ulrika, Jansson, Jan Håkan, Söderberg, Stefan, Eriksson, Sture, Jankovic, Nicole, Sánchez, María-José, Veronesi, Giovanni, Sans, Susana, Drygas, Wojciech, Trichopoulou, Antonia, Boffetta, Paolo, and Brenner, Hermann

Abstract

INTRODUCTION: Smoking is known to be a major cause of death among middle-aged adults, but evidence on its impact and the benefits of smoking cessation among older adults has remained limited. Therefore, we aimed to estimate the influence of smoking and smoking cessation on all-cause mortality in people aged ≥60 years.METHODS: Relative mortality and mortality rate advancement periods (RAPs) were estimated by Cox proportional hazards models for the population-based prospective cohort studies from Europe and the U.S. (CHANCES [Consortium on Health and Ageing: Network of Cohorts in Europe and the U.S.]), and subsequently pooled by individual participant meta-analysis. Statistical analyses were performed from June 2013 to March 2014.RESULTS: A total of 489,056 participants aged ≥60 years at baseline from 22 population-based cohort studies were included. Overall, 99,298 deaths were recorded. Current smokers had 2-fold and former smokers had 1.3-fold increased mortality compared with never smokers. These increases in mortality translated to RAPs of 6.4 (95% CI=4.8, 7.9) and 2.4 (95% CI=1.5, 3.4) years, respectively. A clear positive dose-response relationship was observed between number of currently smoked cigarettes and mortality. For former smokers, excess mortality and RAPs decreased with time since cessation, with RAPs of 3.9 (95% CI=3.0, 4.7), 2.7 (95% CI=1.8, 3.6), and 0.7 (95% CI=0.2, 1.1) for those who had quit <10, 10 to 19, and ≥20 years ago, respectively.CONCLUSIONS: Smoking remains as a strong risk factor for premature mortality in older individuals and cessation remains beneficial even at advanced ages. Efforts to support smoking abstinence at all ages should be a public health priority.

Published
2015

13. Smoking and All-cause Mortality in Older Adults

Author

Müezzinler, Aysel, primary, Mons, Ute, additional, Gellert, Carolin, additional, Schöttker, Ben, additional, Jansen, Eugène, additional, Kee, Frank, additional, O’Doherty, Mark G., additional, Kuulasmaa, Kari, additional, Freedman, Neal D., additional, Abnet, Christian C., additional, Wolk, Alicja, additional, Håkansson, Niclas, additional, Orsini, Nicola, additional, Wilsgaard, Tom, additional, Bueno-de-Mesquita, Bas, additional, van der Schouw, Yvonne T., additional, Peeters, Petra H.M., additional, de Groot, Lisette C.P.G.M., additional, Peters, Annette, additional, Orfanos, Philippos, additional, Linneberg, Allan, additional, Pisinger, Charlotta, additional, Tamosiunas, Abdonas, additional, Baceviciene, Migle, additional, Luksiene, Dalia, additional, Bernotiene, Gailute, additional, Jousilahti, Pekka, additional, Petterson-Kymmer, Ulrika, additional, Jansson, Jan Håkan, additional, Söderberg, Stefan, additional, Eriksson, Sture, additional, Jankovic, Nicole, additional, Sánchez, María-José, additional, Veronesi, Giovanni, additional, Sans, Susana, additional, Drygas, Wojciech, additional, Trichopoulou, Antonia, additional, Boffetta, Paolo, additional, and Brenner, Hermann, additional

Published
2015
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