12 results on '"Mönig C"'
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2. Untersuchungen zur atmosphärischen Ausbreitung von Schadstoffen nach Kurzzeitemissionen in nicht ebenem Gelände : zweite Intensivmeßphase im Juni/Juli 1987 und Ausbreitungsexperimente 1 - 12 von Juni 1987 bis Juli 1988 im Gebiet der Sophienhöhe
- Author
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Zeuner, G., Heinemann, K., Möllmann-Coers, Michael, and Mönig, C.
- Abstract
Zur Bewertung der Auswirkung von Emissionen auf die Umwelt und den Menschen benötigt man u.a. Ausbreitungsrechnungen, die die räumliche Verteilung der bodennahen Konzentrationen als Funktion der atmosphärischen Bedingungen, der Quelldistanz und Quellkonfiguration beschreiben. Zur Zeit werden die meisten Ausbreitungsrechnungen mit dem Gaußschen Fahnenmodell durchgeführt. Bei Langzeitbetrachtungen, wie sie für Genehmigungsverfahren benötigt werden, liefert dieses Modell für ebenes Gelände in der Regel befriedigende Ergebnisse. Bei Kurzzeitausbreitungsrechnungen wie sie z.B. bei Unfällen erforderlich sind, kann das Gaußsche Fahnenmodell allerdings zu Fehlinterpretationen führen, wenn die Ausbreitungsbedingungen sich schnell ändern oder wenn das Gelände nicht eben ist.Um für stark gegliedertes Gelände realistische Immissionsprognosen erstellen zu können, wurden in den vergangenen Jahren Strömungs- und Ausbreitungsmodelleentwickelt, die auf fortgeschrittenen Modellansätzen beruhen. Um solche Modelle allgemein anwenden zu können, müssen sie anhand von experimentellen Datenvalidiert werden, die folgende Informationen enthalten müssen: 1. eine mathematische Beschreibung eines gut vermessenen, befahrbaren und nicht ebenen Versuchsgeländes. 2. simultan zu Ausbreitungsexperime~ten eine möglichst umfassende Ausmessung des Windfeldes mit allen für die Windfeld- und Ausbreitungsmodelle nötigen Eingangsparametern und 3. Ausbreitungsexperimente mit möglichst vielen Meßpunkten zur Ermittlung der bodennahen Verteilungsfunktion des Spurenstoffes für unterschiedliche Ausbreitungsbedingungen. Zur Erstellung solcher Datensätze förderte das Bundesministerium für Umwelt, Naturschutz und Reaktorsicherheit seit dem Jahr 1986 Ausbreitungsuntersuchungen im Bereich der Sophienhöhe, einer Abraumhalde etwa 2 km nordöstlich des Forschungszentrums Jülich. In Abb. 1 ist auf einer skizzierten Landkarte das Versuchsgelände gestrichelt und die Aufstellung unterschiedlicher Meßysteme als Kreise dargestellt. Das Versuchsgelände wird ausführlicher in Kapitel 2 beschrieben. Bei den Eintragungen handelt es sich neben dem vom Forschungszentrum Jülich (KFA) betriebenen meteorologischen Langzeitmeßnetz, das in Kapitel 3 erläutert wird, auch um die Orte der zusätzlichen Doppler-SODAR-Geräte und die Startpunkte für Ballonaufstiege, die während der 2. Intensivmeßphase eingesetzt waren. Die Konzeption der Versuche sah vor, daß das Windfeld kontinuierlich in einem Langzeitmeßnetz erfaßt wird. Während der Intensivmeßphasen, die jährlich stattfanden, wurde das meteorologische Meßnetz und das Probenahmenetz für denSpurenstoff der Ausbreitungsexperimente verdichtet, um eine bessere Information zu erhalten. An der zweiten Intensivmeßphase, die vom 29. Juni bis 3. Juli durchgeführt wurde, haben folgende Gruppen mit ihren Meßgeräten teilgenommen (in Klammern sind die im Text benutzten Abkürzungen angegeben): • Wetteramt Essen, Radiosondenaufstiege mit Radarverfolgung, Pilotballons, Tetroonverfolgung mit Radar • Institut für Geophysik und Meteorologie der Universität zu Köln (IGM Köln), Fesselsonde, Radiosonden • Landesamt für Immissionsschutz, Arbeitsmedizin und Strahlenschutz Hannover (LiS Hannover), Doppler-SODAR (SODAR LlS Hannover) • Rheinisch-Westfälischer Technischer Überwachungsverein e.V. Essen (TÜV Essen), Doppler-SODAR (SODAR TÜV Essen) • Institut für Meteorologie und Klimaforschung des Kernforschungszentrums Karlsruhe (KfK), Tetroons, Doppler-SODAR (SODAR KfK) In Kapitel 4 werden die Ausbreitungsexperimente 1 - 12 dargestellt, die bis zum Beginn der 3. Intensivmeßphase durchgeführt wurden. Die meteorologischen Messungen während der 2. Intensivmeßphase werden in Kapitel 5 beschrieben. Für den Zeitraum der 12 Ausbreitungsexperimente sind die meteorologischen Daten des Langzeitmeßnetzes sowie beispielhaft für ein Experiment der Intensivmeßphase die Resultate aller Meßsysteme in Anhang A zusammengestellt. Die Beschreibung aller Meßwerte und der topographischen Daten des Versuchsgeländes, so wie sie auf Datenträger verfügbar sind, erfolgt in den Anhängen Bund C.
- Published
- 1991
3. Third field experiment on atmospheric dispersion around the isolated hill Sophienhöhe in August/September 1988: methods - experiments - data bank
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Bahmann, W., Becker, K., Polster, G., Voß, W., Oetz, W., Veroustraete, F., Frank, J., Gryning, S. E., Lyck, E., Mextorf, Olaf, Möllmann-Coers, Michael, Mönig, C., Narres, Hans-Dieter, Oetz, C., Zeuner, and Heinemann, K.
- Abstract
In order to set up a data bank for the validation of advanced dispersion models, comprehensive meteorological measurements and dispersion experiments in a complex terrain with a well measured topography are being carried out. These investigations have become possjble in cooperation with several external groups and with the financial support of the "Bundesminister für Umwelt, Naturschutz und Reaktorsicherheit". In this report the methods, experiments and results (data bank) of the third fieid experiment are described.
- Published
- 1990
4. [18F]DPA-714 PET-MR-Bildgebung in seropositiven und seronegativen limbischen Encephalitiden
- Author
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Roll, W, Strippel, C, Zinnhardt, B, Golombeck, KS, Seifert, R, Dik, A, Backhaus, P, Mönig, C, Jacobs, A, Melzer, N, and Schäfers, M
- Published
- 2019
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5. Neuropsychological Performance in Autoimmune Limbic Encephalitis: Evidence from an Immunotherapy-Naïve Cohort.
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Mueller C, Langenbruch L, Rau JMH, Brix T, Strippel C, Dik A, Golombeck KS, Mönig C, Johnen A, Räuber S, Wiendl H, Meuth SG, Bölte J, Kovac S, and Melzer N
- Subjects
- Autoimmune Diseases, Humans, Immunotherapy, Limbic Encephalitis, Middle Aged, Neuropsychological Tests, Retrospective Studies, Autoantibodies, Magnetic Resonance Imaging
- Abstract
Objective: Autoimmune limbic encephalitis (ALE) is characterized by memory impairment, psychiatric symptoms, and epileptic seizures. Though, the neuropsychological profile of ALE is not yet well defined. However, there is some evidence that neuropsychological impairments might exceed those related to the limbic system and that different autoantibodies (AABs) are associated with distinguishable pattern of neuropsychological impairments. We provide a comprehensive presentation of neuropsychological performance of ALE in an immune therapy-naïve sample., Methods: We retrospectively analyzed 69 immunotherapy-naïve ALE-patients (26 seropositive-[8 LGI1-, 4 CASPR2-, 2 GABAB-R-, 3 Hu-, 4 GAD65-, 2 Ma2-, 2 unknown antigen, and 1 Yo-AABs] and 43 seronegative patients, mean age 56.0 years [21.9-78.2], mean disease duration 88 weeks [0-572]). Neuropsychological evaluations comprised of the domains memory, attention, praxis, executive functions, language, social cognition, and psychological symptoms. We compared these functions between seronegative -, seropositive patients with AABs against intracellular neural antigens and seropositive patients with AABs against surface membrane neural antigens., Results: No effect of AAB group on neuropsychological performance could be detected. Overall, ALE predominantly presents with deficits in long-term memory and memory recognition, autobiographical-episodic memory loss, impairment of emotion recognition, and depressed mood. Furthermore, deficits in praxis of pantomimes and imitations, visuo-construction, and flexibility may occur., Conclusion: ALE shows a wide spectrum of neuropsychological impairments, which might exceed the limbic system, with no evidence of differences between AAB groups. Neuropsychological assessment for diagnosing ALE should include long-term memory, memory recognition, autobiographical-episodic memory, emotion recognition, and a detailed investigation of depression., (© The Author(s) 2022. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.)
- Published
- 2022
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6. Lateralized deficits in arousal processing after insula lesions: Behavioral and autonomic evidence.
- Author
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Holtmann O, Franz M, Mönig C, Tenberge JG, Schloßmacher I, Ivanova I, Preul C, Schwindt W, Melzer N, Miltner WHR, and Straube T
- Subjects
- Autonomic Nervous System, Humans, Arousal physiology, Emotions physiology
- Abstract
A large body of evidence ascribes a pivotal role in emotion processing to the insular cortex. However, the complex structure and lateralization of emotional deficits following insular damage are not understood. Here, we investigated emotional ratings of valence and arousal and skin conductance responses (SCR) to a graded series of emotionally arousing scenes in patients with left (n = 10) or right (n = 9) insular damage and in healthy controls (n = 18). We found a significant reduction in overall SCRs, arousal ratings and valence extremity scores in right-lesioned patients, as compared to left-lesioned patients and healthy controls. The degree of right insular damage was significantly correlated with the degree of arousal, SCR and extremity attenuation. Additional analyses of correlations between subjective arousal ratings resp. SCR and normative arousal ratings revealed that both lesion groups had evaluative and physiological difficulties to discover changes in stimulus arousal. Although no group differences emerged on overall ratings of valence, analysis of correlations between subjective and normative valence ratings displayed markedly reduced accuracy in right-lesioned patients, as compared to left-lesioned patients and healthy controls. Our findings support the hypothesis that the left and right insulae subserve different functions in emotion processing, potentially due to asymmetrical representations of autonomic information in the left and right human forebrain. The right insula may serve as integral node for sympathetic arousal and cognitive-affective processing., Competing Interests: Declaration of competing interest None., (Copyright © 2022 Elsevier Ltd. All rights reserved.)
- Published
- 2022
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7. Impact of T cells on neurodegeneration in anti-GAD65 limbic encephalitis.
- Author
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Dik A, Widman G, Schulte-Mecklenbeck A, Witt JA, Pitsch J, Golombeck KS, Wagner J, Gallus M, Strippel C, Hansen N, Mönig C, Räuber S, Wiendl H, Elger CE, Surges R, Meuth SG, Helmstaedter C, Gross CC, Becker AJ, and Melzer N
- Subjects
- Adult, Autoimmune Diseases blood, Autoimmune Diseases cerebrospinal fluid, Cross-Sectional Studies, Female, Humans, Limbic Encephalitis blood, Limbic Encephalitis cerebrospinal fluid, Magnetic Resonance Imaging, Male, Middle Aged, Young Adult, Autoimmune Diseases immunology, Autoimmune Diseases pathology, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Glutamate Decarboxylase immunology, Limbic Encephalitis immunology, Limbic Encephalitis pathology
- Abstract
Objective: Direct pathogenic effects of autoantibodies to the 65 kDa isoform of glutamic acid decarboxylase (GAD65) in autoimmune limbic encephalitis (LE) have been questioned due to its intracellular localization. We therefore hypothesized a pathogenic role for T cells., Methods: We assessed magnet resonance imaging, neuropsychological and peripheral blood, and CSF flow cytometry data of 10 patients with long-standing GAD65-LE compared to controls in a cross-sectional manner. These data were related to each other within the GAD65-LE group and linked to neuropathological findings in selective hippocampectomy specimen from another two patients. In addition, full-resolution human leukocyte antigen (HLA) genotyping of all patients was performed., Results: Compared to controls, no alteration in hippocampal volume but impaired memory function and elevated fractions of activated HLADR
+ CD4+ and CD8+ T cells in peripheral blood and cerebrospinal fluid were found. Intrathecal fractions of CD8+ T cells negatively correlated with hippocampal volume and memory function, whereas the opposite was true for CD4+ T cells. Consistently, antigen-experienced CD8+ T cells expressed increased levels of the cytotoxic effector molecule perforin in peripheral blood, and perforin-expressing CD8+ T cells were found attached mainly to small interneurons but also to large principal neurons together with wide-spread hippocampal neurodegeneration. 6/10 LE patients harbored the HLA-A*02:01 allele known to present the immunodominant GAD65114-123 peptide in humans., Interpretation: Our data suggest a pathogenic effect of CD8+ T cells and a regulatory effect of CD4+ T cells in patients with long-standing GAD65-LE., (© 2021 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.)- Published
- 2021
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8. Enhancing medication therapy in Parkinson's disease by establishing an interprofessional network including pharmacists.
- Author
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Rose O, Happe S, Huchtemann T, Mönig C, Ohms M, Schwalbe O, Warnecke T, and Erzkamp S
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- Health Personnel, Humans, Interprofessional Relations, Quality of Life, Parkinson Disease drug therapy, Parkinson Disease epidemiology, Pharmacists
- Abstract
Background Optimizing therapy regimens through collaboration and combination of available resources is a promising approach to improve quality of life for patients with Parkinson's disease (PD). Aim The aim of this project was to enhance patient-oriented therapy and interprofessional collaboration by establishing a regional PD network. Setting The network is located in a rural area in Germany. It covers primary, secondary and tertiary care facilities across professional boundaries. Development Recruitment of PD specialists and patient support groups was done by the local newspaper to spread the word. The network was initially open to all healthcare professionals, who stated a focus or special interest in PD. A working group for medication was founded within the network by asking for interested participants. Problems in the medication process were discussed within the group. As a consequence, therapy recommendations (quickcards) and a specific medication plan were developed and a certified education curriculum for pharmacists was developed. Implementation The network grew to > 150 participants across all disciplines and sectors. Quickcards were adjusted, approved and implemented by the network during interquartile meetings. Certified education was implemented and became a requirement for participating pharmacists. Evaluation The quickcards on medication plan and drug-drug-interactions were approved to be useful and feasible by the network by unanimous assent. Overall satisfaction with certified education was high (mean of 1.4 on a scale between 1 = high and 6 = low). Conclusion A regional interprofessional PD network with pharmacists was established and new standards were established. Future research needs to measure the effects on patient outcomes.
- Published
- 2021
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9. Lateralized Deficits of Disgust Processing After Insula-Basal Ganglia Damage.
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Holtmann O, Bruchmann M, Mönig C, Schwindt W, Melzer N, Miltner WHR, and Straube T
- Abstract
A growing body of evidence suggests a role of the insular cortex (IC) and the basal ganglia (BG) in the experience, expression, and recognition of disgust. However, human lesion research, probing this structure-function link, has yielded rather disparate findings in single cases of unilateral and bilateral damage to these areas. Comparative group approaches are needed to elucidate whether disgust-related deficits specifically follow damage to the IC-BG system, or whether there might be a differential hemispheric contribution to disgust processing. We examined emotional processing by means of a comprehensive emotional test battery in four patients with left- and four patients with right-hemispheric lesions to the IC-BG system as well as in 19 healthy controls. While single tests did not provide clear-cut separations of patient groups, composite scores indicated selective group effects for disgust. Importantly, left-lesioned patients presented attenuated disgust composites, while right-lesioned patients showed increased disgust composites, as compared to each other and controls. These findings propose a left-hemispheric basis of disgust, potentially due to asymmetrical representations of autonomic information in the human forebrain. The present study provides the first behavioral evidence of hemispheric lateralization of a specific emotion in the human brain, and contributes to neurobiological models of disgust., (Copyright © 2020 Holtmann, Bruchmann, Mönig, Schwindt, Melzer, Miltner and Straube.)
- Published
- 2020
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10. Onconeural antigen spreading in paraneoplastic neurological disease due to small cell lung cancer.
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Dik A, Strippel C, Mönig C, Golombeck KS, Schulte-Mecklenbeck A, Wiendl H, Meuth SG, Johnen A, Gross CC, and Melzer N
- Abstract
Cellular and humoral immunity towards distinct onconeural antigens is the hallmark of paraneoplastic neurological diseases (PNDs). Stable formation of immunoglobulin (Ig) G antibodies to particular onconeural antigens occurs in the majority of cases, whereas persistent coexistence of antibodies specific for multiple onconeural antigens is a relatively rare phenomenon of certain malignant tumors like small cell lung cancer (SCLC). We here describe onconeural antigen spreading in a 70-year-old Caucasian male with PND due to SCLC. Onconeural antigen spreading may be promoted by two mutually non-exclusive mechanisms: (i) a switch of antigen expression pattern of the underlying tumor tissue as a result of a mutagenic process caused by the cancer itself and (ii) a self-propagated paraneoplastic immune response with persistent neuronal destruction, liberation, processing and presentation of intracellular neural antigens. This illustrates a potential dissociation between peripheral anti-tumoral immunity and central anti-neural immunity during the course of PND.
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- 2018
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11. Treating refractory post-herpetic anti- N -methyl-d-aspartate receptor encephalitis with rituximab.
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Strippel C, Mönig C, Golombeck KS, Dik A, Bönte K, Kovac S, Schulte-Mecklenbeck A, Wiendl H, Meuth SG, Johnen A, Gross CC, and Melzer N
- Abstract
Herpes simplex virus-1 has been identified as the trigger factor in certain cases of NMDA-receptor autoimmune encephalitis. We report on a 67-year-old female patient, who was severely affected by post-herpetic NMDA-receptor autoimmune encephalitis. Her symptoms did not improve under methylprednisolone pulse therapy and plasma exchange under acyclovir prophylaxis. She received protein A immunoadsorption and a long-term immunosuppression with rituximab. Under treatment, activated T-cells as well as B- and plasma cells decreased in peripheral blood and cerebrospinal fluid, and anti-NMDA-R IgG titers in serum and cerebrospinal fluid declined with near complete cessation of intrathecal autoantibody synthesis. The patient regained near complete independence and profoundly improved on formal neuropsychological assessment. Despite reduction of antiviral defense through of lowered activated T cells and concomitantly decreasing HSV-specific IgG antibodies, no evidence of viral reactivation was detected.
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- 2017
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12. Evidence of a pathogenic role for CD8(+) T cells in anti-GABAB receptor limbic encephalitis.
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Golombeck KS, Bönte K, Mönig C, van Loo KM, Hartwig M, Schwindt W, Widman G, Lindenau M, Becker AJ, Glatzel M, Elger CE, Wiendl H, Meuth SG, Lohmann H, Gross CC, and Melzer N
- Abstract
Objectives: To characterize the cellular autoimmune response in patients with γ-aminobutyric acid (GABA)B receptor antibody-associated limbic encephalitis (GABAB-R LE)., Methods: Patients underwent MRI, extensive neuropsychological assessment, and multiparameter flow cytometry of peripheral blood and CSF., Results: We identified a series of 3 cases of nonparaneoplastic GABAB-R LE and one case of paraneoplastic GABAB-R LE associated with small cell lung cancer. All patients exhibited temporal lobe epilepsy, neuropsychological deficits, and MRI findings typical of LE. Absolute numbers of CD19(+) B cells, CD138(+) CD19(+) plasma cells, CD4(+) T cells, activated HLADR(+) CD4(+) T cells, as well as CD8(+) T cells and HLADR(+) CD8(+) T cells did not differ in peripheral blood but were elevated in CSF of patients with GABAB-R LE compared to controls. Augmented absolute numbers of CD138(+) CD19(+) plasma cells and activated HLADR(+) CD8(+) T cells in CSF corresponded to higher overall neuropsychological and memory deficits in patients with GABAB-R LE. A histologic specimen of one patient following selective amygdalohippocampectomy revealed perivascular infiltrates of CD138(+) plasma cells and CD4(+) T cells, whereas cytotoxic CD8(+) T cells were detected within the brain parenchyma in close contact to neurons., Conclusion: Our data suggest a pathogenic role for CD8(+) T cells in addition to the established role of plasma cell-derived autoantibodies in GABAB-R LE.
- Published
- 2016
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