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302 results on '"Möhlig M"'

24. Combination Chemotherapy in Advanced Adrenocortical Carcinoma

Author

Fassnacht, M., Terzolo, M., Allolio, B., Baudin, E., Haak, H., Berruti, A., Welin, S., Schade Brittinger, C., Lacroix, A., Jarzab, B., Sorbye, H., Torpy, D. J., Stepan, V., Schteingart, D. E., Arlt, W., Kroiss, M., Leboulleux, S., Sperone, P., Sundin, A., Hermsen, I., Hahner, S., Willenberg, H. S., Tabarin, A., Quinkler, M., De La Fouchardiere, C., Schlumberger, M., Mantero, F., Weismann, D., Beuschlein, F., Gelderblom, H., Wilmink, H., Sender, M., Edgerly, M., Kenn, W., Fojo, T., Muller, H. H., Skogseid, B., Haaf, M., Johanssen, S., Koschker, A. C., Laubner, K., Sbiera, S., Schiemann, J., Wortmann, S., Haase, M., Schott, M., Möhlig, M., Zopf, K., Reisch, N., Betz, M., Reincke, M., Isermann, B., Bornstein, S., Fottner, C., Bose, A., Petersenn, S., Leitolf, H., Klose, S., Wolf, H., Chougnet, C., More, J., Nunes, M. L., Droz, J. P., Nicolli, P., Chabre, O., Clergeot, A., Schillo, F., Penfornis, A., Do Cao, C., Goldwasser, F., Rodien, P., Ferrero, A., Perotti, P., Cicala Mv, Anna P., Della Casa, S., Mannelli, M., Piccini, V., Dercksen, M. W., Romijn, J. A., Ouwerkerk, J., Devries, J. H., Eriksson, B., Janson, E. T., Granberg, D., Oberg, K., Ahlman, H., Garkavij, M., Wall, N., Falkmer, U., Hammer, G., Olney, H. J., Bourdeau, I., Bourque, L., Szpak Ulczok, S., Jarzab, M., Holte, H., Fossa, A., Ploner, F., Mansmann, U., Schmoll, H. J., Simonsson, B., Toscano, Vincenzo, Petersenn, Stephan (Beitragende*r), CCA -Cancer Center Amsterdam, Oncology, Other departments, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, General Internal Medicine, and Endocrinology

Subjects
Adult, Male, adrenal tumor, medicine.medical_specialty, Medizin, Kaplan-Meier Estimate, Gastroenterology, Disease-Free Survival, Streptozocin, Young Adult, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Adrenocortical Carcinoma, Medicine, Adrenocortical carcinoma, Humans, Mitotane, Adverse effect, Etoposide, Aged, Intention-to-treat analysis, business.industry, Medicine (all), Hazard ratio, Combination chemotherapy, General Medicine, Middle Aged, medicine.disease, Adrenal Cortex Neoplasms, Surgery, Intention to Treat Analysis, Regimen, Doxorubicin, Cisplatin, Female, Quality of Life, business, medicine.drug
Abstract

A b s t r ac t Background Adrenocortical carcinoma is a rare cancer that has a poor response to cytotoxic treatment. Methods We randomly assigned 304 patients with advanced adrenocortical carcinoma to re ceive mitotane plus either a combination of etoposide (100 mg per square meter of body-surface area on days 2 to 4), doxorubicin (40 mg per square meter on day 1), and cisplatin (40 mg per square meter on days 3 and 4) (EDP) every 4 weeks or streptozocin (streptozotocin) (1 g on days 1 to 5 in cycle 1; 2 g on day 1 in subsequent cycles) every 3 weeks. Patients with disease progression received the alternative regimen as second-line therapy. The primary end point was overall survival. Results For first-line therapy, patients in the EDP–mitotane group had a significantly higher response rate than those in the streptozocin–mitotane group (23.2% vs. 9.2%, P

Published
2012
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28. Preferential deposition of visceral adipose tissue occurs due to physical inactivity

Author

Belavý, D.L., Möhlig, M., Pfeiffer, A., Felsenberg, D., Armbrecht, G., Belavý, D.L., Möhlig, M., Pfeiffer, A., Felsenberg, D., and Armbrecht, G.

Abstract

We hypothesised that strict inactivity (bed rest) would lead to regional differences in fat deposition. Twenty-four male subjects underwent 60d bed rest and remained inactive (n = 9), performed resistance exercise plus whole-body vibration (RVE; n = 7) or resistance exercise only (RE; n = 8). Fat mass was assessed via dual X-ray absorptiometry. In the inactive subjects, fat deposition differed between body regions (P = 0.0005) with android region visceral adipose tissue increasing the most (+29% at the end of bed rest), followed by remainder of the trunk (from chin to the iliac crest; +10%) and the arms and legs (both +7%). Insulin sensitivity reduced in the inactive subjects at the end of bed rest (P = 0.036). RE did not have a significant impact on regional fat mass changes (P ≥ 0.055). In RVE, increases in visceral adipose tissue (-14%; P = 0.028 vs inactive subjects) and in the arms (arms -8%, P = 0.011 vs inactive) were not seen. We conclude that inactivity leads to a preferential increase in visceral adipose tissue.

Published
2014

29. Elevated hepatic chemerin mRNA expression in human non-alcoholic fatty liver disease

Author

Döcke, S, primary, Lock, J F, additional, Birkenfeld, A L, additional, Hoppe, S, additional, Lieske, S, additional, Rieger, A, additional, Raschzok, N, additional, Sauer, I M, additional, Florian, S, additional, Osterhoff, M A, additional, Heller, R, additional, Herrmann, K, additional, Lindenmüller, S, additional, Horn, P, additional, Bauer, M, additional, Weickert, M O, additional, Neuhaus, P, additional, Stockmann, M, additional, Möhlig, M, additional, Pfeiffer, A F H, additional, and von Loeffelholz, C, additional

Published
2013
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34. Reduzierte AMP-aktivierte Proteinkinase (AMPK) und reduziertes Plasma Adiponektin bei humaner nicht-alkoholischer Fettlebererkrankung (NAFLD)

Author

Loeffelholz, C von, primary, Lock, JF, additional, Döcke, S, additional, Möhlig, M, additional, Birkenfeld, AL, additional, Hoppe, S, additional, Bumke-Vogt, C, additional, Florian, S, additional, Rieger, A, additional, Ringe, S, additional, Isken, F, additional, Osterhoff, MA, additional, Claus, RA, additional, Bauer, M, additional, Neuhaus, P, additional, Weickert, MO, additional, Stockmann, M, additional, and Pfeiffer, AFH, additional

Published
2012
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35. Annual Change in Insulin Sensitivity

Author

Isken, F., additional, Abraham, U., additional, Weickert, M., additional, Keyhani-Nejad, F., additional, Arafat, A., additional, Spranger, J., additional, Pfeiffer, A.F., additional, and Möhlig, M., additional

Published
2011
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49. Assoziation zwischen IL6–174G>C und Diabetes mellitus Typ 2 sowie quantitativen Nüchternglucosespiegeln – Eine Individualdatenanalyse 21 internationaler Studien

Author

Huth, C, primary, Illig, T, additional, Herder, C, additional, Gieger, C, additional, Grallert, H, additional, Vollmert, C, additional, Rathmann, W, additional, Martin, S, additional, Hamid, YH, additional, Pedersen, O, additional, Hansen, T, additional, Thorand, B, additional, Meisinger, C, additional, Döring, A, additional, Klopp, N, additional, Gohlke, H, additional, Langer, B, additional, Lieb, W, additional, Hengstenberg, C, additional, Lyssenko, V, additional, Groop, L, additional, Irland, H, additional, Stephens, JW, additional, Wernstedt, I, additional, Niklason, A, additional, Jansson, JO, additional, Boeing, H, additional, Möhlig, M, additional, Spranger, J, additional, Pfeiffer, AFH, additional, Stringham, HM, additional, Boehnke, M, additional, Tuomilehto, J, additional, Fernandez-Real, JM, additional, Lopez-Bermejo, A, additional, Gallart, L, additional, Vendrell, J, additional, Tsiavou, A, additional, Hatziagelaki, E, additional, Hanson, RL, additional, Wolford, JK, additional, Humphries, SE, additional, Kronenberg, F, additional, Wichmann, HE, additional, and Heid, IM, additional

Published
2008
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