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17 results on '"Ménégaut, Louise"'

3. Deletion of lysophosphatidylcholine acyltransferase 3 in myeloid cells worsens hepatic steatosis after a high-fat diet

Author

Bourgeois, Thibaut, Jalil, Antoine, Thomas, Charles, Magnani, Charlène, Le Guern, Naig, Gautier, Thomas, Pais de Barros, Jean-Paul, Bergas, Victoria, Choubley, Hélène, Mazzeo, Loïc, Menegaut, Louise, Josiane Lebrun, Lorène, Van Dongen, Kévin, Xolin, Marion, Jourdan, Tony, Buch, Chloé, Labbé, Jérome, Saas, Philippe, Lagrost, Laurent, Masson, David, and Grober, Jacques

Published
2021
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4. Interplay between Liver X Receptor and Hypoxia Inducible Factor 1α Potentiates Interleukin-1β Production in Human Macrophages

Author

Ménégaut, Louise, Thomas, Charles, Jalil, Antoine, Julla, Jean Baptiste, Magnani, Charlène, Ceroi, Adam, Basmaciyan, Louise, Dumont, Adélie, Le Goff, Wilfried, Mathew, Mano Joseph, Rébé, Cédric, Dérangère, Valentin, Laubriet, Aline, Crespy, Valentin, Pais de Barros, Jean-Paul, Steinmetz, Eric, Venteclef, Nicolas, Saas, Philippe, Lagrost, Laurent, and Masson, David

Published
2020
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10. Regulation of glycolytic genes in human macrophages by oxysterols: a potential role for Liver X receptors Oxysterols modulate glycolysis in human macrophages

Author

Ménégaut, Louise, Jalil, Antoine, Pilot, Thomas, Van Dongen, Kevin, Crespy, Valentin, Steinmetz, Eric, Pais de Barros, Jean Paul, Geissler, Audrey, Le Goff, Wilfried, Venteclef, Nicolas, Lagrost, Laurent, Gautier, Thomas, Thomas, Charles, Masson, David, Lipides - Nutrition - Cancer [Dijon - U1231] (LNC), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire d'Excellence : Lipoprotéines et Santé : prévention et Traitement des maladies Inflammatoires et du Cancer (LabEx LipSTIC), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut Gustave Roussy (IGR)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Bourgogne (UB)-Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon)-Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM)-Fédération Francophone de la Cancérologie Digestive, FFCD-Université de Montpellier (UM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté])-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHU Dijon, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Université Bourgogne Franche-Comté [COMUE] (UBFC), Plateforme d'Imagerie Cellulaire [Dijon] (CellImaP), Université de Bourgogne (UB)-IFR100 - Structure fédérative de recherche Santé-STIC, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP)

Subjects
[SDV]Life Sciences [q-bio], polycyclic compounds, lipids (amino acids, peptides, and proteins), Oxysterols, glycolysis, Liver X Receptors, macrophages
Abstract

International audience; Background and purpose: Subset of macrophages within the atheroma plaque displays a high glucose uptake activity. Nevertheless, the molecular mechanisms as well as the pathophysiological significance of this high glucose need remain unclear. While a role for hypoxia and hypoxia inducible factor 1α has been demonstrated, the contribution of lipid microenvironment and more specifically oxysterols is yet to be explored.Experimental approach: Human macrophages were conditioned in the presence of homogenates from human carotid plaques and expression of genes involved in glucose metabolism was quantified. Correlative analyses between gene expression and the oxysterol composition of plaques were performed.Key results: Conditioning of human macrophages by plaque homogenates induces expression of several genes involved in glucose uptake and glycolysis including glucose transporter 1 (GLUT1), and hexokinases 2 and 3 (HK2 and HK3), This activation is significantly correlated to the oxysterol content of the plaque samples and is associated with a significant increase in the glycolytic activity of the cells. Pharmacological inverse agonist of the oxysterol receptor Liver X Receptor (LXR) partially reverses the induction of glycolysis genes without affecting macrophage glycolytic activity. Chromatin immunoprecipitation analysis confirms the implication of LXR in the regulation of GLUT1 and HK2 CONCLUSIONS AND IMPLICATIONS: While our work supports a role of oxysterols and LXR in the modulation of macrophage metabolism in atheroma plaques, it also highlights some LXR-independent effects of plaques samples. Finally, this study identifies the hexokinase HK3 as a promising target in the context of atherosclerosis.

Published
2020
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11. Regulation of glycolytic genes in human macrophages by oxysterols: a potential role for liver X receptors

Author

Ménégaut, Louise, primary, Jalil, Antoine, additional, Pilot, Thomas, additional, van Dongen, Kevin, additional, Crespy, Valentin, additional, Steinmetz, Eric, additional, Pais de Barros, Jean Paul, additional, Geissler, Audrey, additional, Le Goff, Wilfried, additional, Venteclef, Nicolas, additional, Lagrost, Laurent, additional, Gautier, Thomas, additional, Thomas, Charles, additional, and Masson, David, additional

Published
2021
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13. Fatty acids and macrophage functions

Author

Ménégaut , Louise, Lagrost , Laurent, Thomas , Charles, Masson , David, Lipides - Nutrition - Cancer (U866) ( LNC ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon ( ENSBANA ), Equipe LIPNESS (LNC - U1231) ( LIPNESS ), Lipides - Nutrition - Cancer [Dijon - U1231] ( LNC ), and Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Santé et de la Recherche Médicale ( INSERM )

Subjects
FA metabolism, macrophage polarization, [ SDV.AEN ] Life Sciences [q-bio]/Food and Nutrition, M1/M2 macrophage function
Abstract

IF 4.096; International audience; Purpose of review Recent studies have highlighted that macrophages dynamically and autonomously handle all the facets of fatty acid (FA) metabolism including FA oxidation and FA synthesis as well as the synthesis of monounsaturated FAs and long chain n-3 and n-6 polyunsaturated FAs.Recent findings Macrophage M2 polarization is associated with an increase of FA oxidation. However, whether increased FA oxidation simply correlates with or is required for M2 polarization needs to be further evaluated. Macrophage M1 polarization is associated with the activation of FA synthesis, which directly contributes to the inflammatory response and affects cholesterol homeostasis and neutral lipid accumulation. Finally, recent evidences suggest that macrophages are able to autonomously produce signaling monounsaturated FAs, such as palmitoleic acid (C16 : 1 n-7), and long chain n-3 and n-6 polyunsaturated FAs, such as arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid. This pathway is regulated by liver X receptors and has significant consequences on inflammation and on the FA composition of atheroma plaques.Summary These studies shed new light on the tight relationship between FA metabolism, macrophage polarization, and M1/M2 macrophage functions. These processes may have major consequences for atherosclerosis pathogenesis as well as other metabolic disorders.

Published
2017
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14. Are Adiponectin and Leptin Good Predictors of Surgical Infection after Colorectal Surgery? A Prospective Study.

Author

Ortega-Deballon, Pablo, Ménégaut, Louise, Fournel, Isabelle, Orry, David, Masson, David, Binquet, Christine, Facy, Olivier, and Ménégaut, Louise

Subjects
*ACADEMIC medical centers, *BLOOD plasma, *LONGITUDINAL method, *MEDICAL specialties & specialists, *PROGNOSIS, *RISK assessment, *SURGICAL site infections, *LEPTIN, *ADIPONECTIN
Abstract

Background: Infections are the most frequent complication after colorectal surgery. It has been suggested that adipose tissue metabolism could be related to the risk of post-operative infection, but this could be partially related to the body-mass index. The aim of this study was to look for a relation between adipocytokine levels and the risk of post-operative infection and its type.Methods: This prospective cohort study was conducted between March 2013 and March 2014 in two French teaching hospitals. Pre-operative plasma levels of adiponectin and leptin were measured in consecutive patients undergoing elective colorectal surgery. All infections in the 30 d following surgery were recorded.Results: Among the 142 patients included, 29 (20.4%) presented a post-operative infection: 26 surgical site infections and three extra-abdominal infections. Adiponectin and leptin levels correlated weakly but substantially with the body mass index (rspearman=-0.26 and +0.31, respectively). While there was no substantial difference between patients with and those without post-operative infection for adiponectin, median pre-operative leptin was substantially greater in patients with post-operative infection (8.67 vs. 4.37 ng/mL, p=0.003). A substantial interaction was found between leptin and cancer. In patients operated on for cancer, the area under the receiver-operating characteristic (ROC) curve was lower than in patients with benign diseases (0.597 vs. 0.858, p=0.011). Similar results were observed for intra-abdominal infection and surgical site infection.Conclusion: Patients with greater levels of leptin before colorectal surgery have an increased risk of post-operative surgical infection. This effect is stronger in patients without cancer. Adiponectin levels are not related to the risk of infection in Western patients. [ABSTRACT FROM AUTHOR]

Published
2015
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16. Liver X Receptor Activation Promotes Polyunsaturated Fatty Acid Synthesis in Macrophages

Author

Varin, Alexis, primary, Thomas, Charles, additional, Ishibashi, Minako, additional, Ménégaut, Louise, additional, Gautier, Thomas, additional, Trousson, Amalia, additional, Bergas, Victoria, additional, de Barros, Jean Paul Pais, additional, Narce, Michel, additional, Lobaccaro, Jean Marc A., additional, Lagrost, Laurent, additional, and Masson, David, additional

Published
2015
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17. Is the stability of ACTH in whole blood a genuine concern during the preanalytical phase? A systematic review.

Author

Dib, Ahmad, Leleu, Damien, Lemaire, Stéphanie, Duvillard, Laurence, Ménégaut, Louise, and Denimal, Damien

Subjects
*ADRENOCORTICOTROPIC hormone, *ACCEPTANCE sampling, *DATABASES, *PATHOLOGICAL laboratories, *BLOOD sampling
Abstract

Adrenocorticotropic hormone (ACTH) has historically been considered an unstable hormone after venous sampling, necessitating stringent conditions for the transport of blood samples to the laboratory to ensure accurate measurement. However, recent investigations suggest that ACTH may be more stable than previously assumed, raising the possibility of more flexible handling conditions. This prompted us to conduct a systematic review using the MEDLINE database to ascertain the stability of ACTH in blood samples. We included 9 studies in our final analysis from 405 reports. Our findings reveal that all studies reported a mean percentage difference (PD%) in ACTH concentrations relative to baseline below the 10% threshold when uncentrifuged tubes were stored under refrigerated conditions for 2, 4, 6, and 8 hours. In contrast, the mean PD% exceed the 10% threshold in 5 out of 7 studies investigating a storage duration of 24 hours under refrigerated conditions. Nearly all studies reported a mean PD% in ACTH concentrations relative to baseline below 10% when uncentrifuged tubes were stored at room temperature for 2, 4, and 6 hours. However, for storage durations of 8, 12, and 24 hours at room temperature, most studies observed a mean PD% exceeding 10%. In summary, our findings suggest that ACTH remains stable in uncentrifuged tubes containing EDTA for 6 h at room temperature and at least 8 h under refrigerated conditions. Our findings can assist clinical laboratories in reviewing their acceptance criteria for sample transport regarding time and temperature. [ABSTRACT FROM AUTHOR]

Published
2025
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