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305 results on '"Mára, M."'

3. Performance of a Simple Custom Air-Water Harvester Using Several Pipe Diameters as the Condensation Unit

Author

Mirmanto, M., Syahrul, S., Joniarta, I. W., Azari, A., Fahroni, A., Mara, M., Nurpatria, N., Wijayanta, A. T., Chan, Albert P.C., Series Editor, Hong, Wei-Chiang, Series Editor, Mellal, Mohamed Arezki, Series Editor, Narayanan, Ramadas, Series Editor, Nguyen, Quang Ngoc, Series Editor, Ong, Hwai Chyuan, Series Editor, Sachsenmeier, Peter, Series Editor, Sun, Zaicheng, Series Editor, Ullah, Sharif, Series Editor, Wu, Junwei, Series Editor, Zhang, Wei, Series Editor, Sugiman, Sugiman, editor, Asmara, Yuli Panca, editor, Ray, Pravat Kumar, editor, and Wijayanta, Agung Tri, editor

Published
2023
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8. Latin American anaphylaxis registry

Author

Jares, Edgardo J., Cardona, Victoria, Gómez, R. Maximiliano, Bernstein, Jonathan A., Rosario Filho, Nelson A., Cherrez-Ojeda, Ivan, Ensina, Luis Felipe, De Falco, Alicia, Díaz, María C., Chávez Vereau, Pierre A., Rocha Felix, Mara M., Lavrut, Jorge, Moreno Laflor, Oscar I., Latour Staffeld, Patricia, Piraino, Pedro, Alacaraz Duarte, Perla, Ivancevich, Juan C., Dabove, Fabian, Giavina-Bianchi, Pedro, Tinoco Moran, Iván O., Nunes Oliviera, Fabiana A., Monsell, Silvana, Souza, María V., Cepeda, Alfonso M., Slullitel, Pablo D., and Morfin-Maciel, Blanca M.

Published
2023
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21. Performance of the LHCb muon system

Author

Alves Jr, A. A., Anderlini, L., Anelli, M., Nobrega, R. Antunes, Auriemma, G., Baldini, W., Bencivenni, G., Berutti, R., Bizzeti, A., Bocci, V., Bondar, N., Bonivento, W., Botchin, B., Cadeddu, S., Campana, P., Carboni, G., Cardini, A., Carletti, M., Ciambrone, P., De Capua, E. Dané S., De Leo, V., Deplano, C., De Simone, P., Dettori, F., Falabella, A., Rodriguez, F. Ferreira, Frosini, M., Furcas, S., Furfaro, E., Graziani, G., Gruber, L., Haefeli, G., Kashchuk, A., Iacoangeli, F., Lai, A., Lanfranchi, G., Lenzi, M., Mair, O. Levitskaya K., Maev, O., Manca, G., Mara, M., Martellotti, G., Rodrigues, A. Massafferri, Messi, R., Murtas, F., Neustroev, P., Oldeman, R. G. C., Palutan, M., Passaleva, G., Penso, G., Pinci, D., Polycarpo, E., Raspino, D., Sabatino, G., Saitta, B., Salamon, A., Santacesaria, R., Santovetti, E., Saputi, A., Sarti, A., Satriano, C., Satta, A., Savrié, M., Schmidt, B., Schneider, T., Sciascia, B., Sciubba, A., Serra, N., Shatalov, P., Vecchi, S., Veltri, M., Volkov, S., and Vorobyev, A.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

The performance of the LHCb Muon system and its stability across the full 2010 data taking with LHC running at ps = 7 TeV energy is studied. The optimization of the detector setting and the time calibration performed with the first collisions delivered by LHC is described. Particle rates, measured for the wide range of luminosities and beam operation conditions experienced during the run, are compared with the values expected from simulation. The space and time alignment of the detectors, chamber efficiency, time resolution and cluster size are evaluated. The detector performance is found to be as expected from specifications or better. Notably the overall efficiency is well above the design requirements, Comment: JINST_015P_1112 2013

Published
2012
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28. Serum cholesterol trajectories in the 10 years prior to lymphoma diagnosis

Author

Cancer Research Network Lymphoma Study Group, Alford, Sharon Hensley, Divine, George, Chao, Chun, Habel, Laurel A., Janakiraman, Nalini, Wang, Yun, Feigelson, Heather Spencer, Scholes, Delia, Roblin, Doug, Epstein, Mara M., Engel, Lawrence, Havstad, Suzanne, Wells, Karen, Yood, Marianne Ulcickas, Fortuny, Joan, and Johnson, Christine Cole

Published
2018

42. Leiomyoma with Bizarre Nuclei: a Study of 108 Cases Focusing on Clinicopathological Features, Morphology, and Fumarate Hydratase Alterations

Author

Michaela Bártů, Barbora Boudova, Ivana Tichá, Jan Laco, Kristýna Němejcová, Mára M, Pavel Dundr, Jan Hojný, Lukáš Krbal, and Mária Gregová

Subjects
Adult, 0301 basic medicine, Cancer Research, Pathology, medicine.medical_specialty, Gene mutation, Fumarate Hydratase, Pathology and Forensic Medicine, Pathogenesis, 03 medical and health sciences, 0302 clinical medicine, Biomarkers, Tumor, Humans, Medicine, Gene, Aged, Cell Nucleus, Leiomyoma, Smooth Muscle Neoplasm, biology, business.industry, General Medicine, Middle Aged, medicine.disease, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Fumarase, Mutation, Uterine Neoplasms, biology.protein, Immunohistochemistry, Female, Antibody, business
Abstract

Leiomyoma with bizarre nuclei (LBN) is an uncommon variant of uterine smooth muscle neoplasm. Involvement of fumarate hydratase (FH) has been suggested in the pathogenesis of a subset of LBN. The goal of our study is to assess the clinicopathological, morphological, immunohistochemical and molecular findings focusing on FH in LBNs (n = 108) and compare it with the findings in usual leiomyomas (UL; n = 50) and leiomyosarcomas (LMS; n = 42). Immunohistochemically, loss of FH expression was found in 67/108 of LBN, 1/50 of UL and in no LMS. Class 4/5 FH mutations were detected in 15/53 LBN with sufficient DNA quality for molecular analysis. Pathogenic variants of the FH gene were detected in neither UL nor LMS. Local recurrence after surgery was present in 18/92 of LBN patients, 7 of which were histologically verified and 2 of which were found to be LBN. Our results confirmed that LBN behave in a benign fashion, although they may relapse. FH gene mutations were a common finding only in LBN, but not in UL and LMS. Immunohistochemistry with an antibody against FH seems to have a good sensitivity (87%) and moderate specificity (58%) with regard to predicting FH gene mutations and could be used as a screening method in tumors with features suggestive of FH alterations to identify patients who are at risk for the FH aberrations.

Published
2019
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43. Uterine cellular leiomyomas are characterized by common HMGA2 aberrations, followed by chromosome 1p deletion and MED12 mutation: morphological, molecular, and immunohistochemical study of 52 cases

Author

Ivana Stružinská, Adéla Richtárová, Kristýna Němejcová, Romana Michálková, Pavel Dundr, Tomáš Zima, Jan Laco, Michaela Bártů, Mária Gregová, Jan Hojný, Mára M, Eva Krkavcová, and Nikola Hájková

Subjects
Stromal cell, Uterine leiomyoma, Mediator Complex, biology, Leiomyoma, Calponin, HMGA2 Protein, Cell Biology, General Medicine, Molecular biology, Chromosomes, Pathology and Forensic Medicine, MED12, Endometrial Neoplasms, Caldesmon, Mutation, Uterine Neoplasms, biology.protein, Immunohistochemistry, Smoothelin, Humans, Desmin, Female, Neprilysin, Molecular Biology
Abstract

Cellular leiomyoma (CL) represents an uncommon variant of uterine leiomyoma with limited data concerning its immunohistochemical and molecular profile. We performed a comprehensive analysis of 52 CL cases all of which were analyzed immunohistochemically. Molecular analysis was possible in 32 cases with sufficient DNA, and 38 cases with sufficient RNA. The immunohistochemical results showed a high expression of smooth muscle markers (calponin (100%), desmin (100%), smooth muscle actin (98.1%), caldesmon (96.1%), transgelin (96.1%), smooth muscle myosin heavy chain (86.5%), and smoothelin (61.5%)). Concerning markers of endometrial stromal differentiation, the expression of CD10 was observed in 65.4% cases (42.2% with H-score > 50), and IFITM1 in 36.5% cases (1.9% with H-score > 50). 36.5% showed HMGA2 overexpression at the IHC level, associated with increased mRNA expression in 14/14 cases. The rearrangement of the HMGA2 gene was detected in 13.2%. Chromosome 1p deletion was found in 19.3%, while 9.4% of tumors showed a pathogenic mutation in the MED12 gene. In conclusion, CL is immunohistochemically characterized by a high expression of "smooth muscle" markers commonly associated with a co-expression of "endometrial stromal" markers, where IFITM1 shows superior performance compared to CD10 regarding its specificity for differentiation from endometrial stromal tumors. The sensitivity of smoothelin in CL seems rather low, but no data is available to assess its specificity. On a molecular level, the most common mutually exclusive aberration in CL affects HMGA2, followed by chromosome 1p deletions and MED12 mutations.

Published
2021

48. Hysteroscopic management of endometrial polyps and submucous leiomyomas in women using a levonorgestrel-releasing intrauterine system

Author

David Kuzel, Barbora Boudova, Z. Zizka, Zdenka Lisa, M. Fanta, Mára M, and Tereza Cindrova-Davies

Subjects
medicine.medical_specialty, Levonorgestrel, 03 medical and health sciences, 0302 clinical medicine, Polyps, medicine, Endometrial Polyp, Humans, neoplasms, Gynecology, Uterine leiomyoma, medicine.diagnostic_test, Leiomyoma, business.industry, Intrauterine Devices, Medicated, female genital diseases and pregnancy complications, surgical procedures, operative, Hysteroscopy, 030220 oncology & carcinogenesis, Uterine Neoplasms, 030211 gastroenterology & hepatology, Surgery, Female, Uterine Hemorrhage, business, medicine.drug
Abstract

This study was designed to evaluate the feasibility and effectiveness of hysteroscopy in the management of symptoms related to endometrial polyps and submucous leiomyomas in women using a levonorgestrel-releasing intrauterine system (LNG-IUS).Twenty-three LNG-IUS users presenting with endometrial polyps and/or submucous leiomyomas and irregular uterine bleeding were recruited for hysteroscopic examination and surgery. Intrauterine pathology was investigated and treated by hysteroscopic resection with the LNG-IUSIntrauterine pathology was successfully resected by hysteroscopy in 23 (100.0%) out of 23 cases. Following hysteroscopy, 18 (78.3%) women reported amenorrhea, one (4.3%) regular spotting, three (13.0%) irregular spotting and one (4.3%) patient resumed normal menstrual cycle. We conclude that 19 (82.6%) patients were postoperatively asymptomatic. All procedures were uncomplicated and 4 (17.4%) were carried out without general anesthesia as office procedures.Endometrial polyps and submucous leiomyomas can develop in LNG-IUS users, and this can cause irregular uterine bleeding. Hysteroscopic resection of these pathologies is a feasible method in the clinical management of symptoms.

Published
2021

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