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1. Assessment Of Associations Between Geriatric Nutrition Risk Index And Sarcopenia In Chronic Kidney Disease Of Unknown Etiology (CKDu) Patients In Sri Lanka

Author: H.M. Abeywickrama, Y. Koyama, M. Uchiyama, and S. Wimalasiri
Subjects: Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism
Published: 2023
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2. Application and outcomes of a standardized lymphadenectomy in laparoscopic right hemicolectomy requiring ligation of the middle colic artery

Author: M. Shiozawa, Sumito Sato, Takashi Oshima, N Sugano, Munetaka Masuda, M Uchiyama, A Kato, Yasushi Rino, and Keisuke Kazama
Subjects: medicine.medical_specialty, business.industry, medicine.medical_treatment, Gastroenterology, Transverse colon, Perioperative, Colorectal surgery, Surgery, 03 medical and health sciences, Dissection, Middle colic artery, 0302 clinical medicine, 030220 oncology & carcinogenesis, medicine.artery, medicine, Ascending colon, 030211 gastroenterology & hepatology, Lymphadenectomy, Superior mesenteric artery, business
Abstract: Complete mesocolic excision with central vessel ligation may be important for accurate staging and improving the prognosis of right-sided colon cancer. Although the procedure is often performed laparoscopically, approaching the middle colic artery (MCA) is technically demanding, especially when complete ligation of arteries at their roots is desired. We standardized our laparoscopic approach by establishing the dissection boundary along the superior mesenteric artery to achieve D3 lymphadenectomy in the region of the MCA. The aim of the present study was to evaluate, on the basis of perioperative and short-term oncologic outcomes, the feasibility and safety of our technique We conducted a retrospective study on consecutive patients with cancer located at the ascending colon and transverse colon who had laparoscopic right hemicolectomy requiring ligation of the MCA. There were 41 patients (22 males, median age 71 years [range 49–86] years). The median operation time was 285 min, and blood loss volume was 40 mL. Conversion to open surgery was required in 1 case. Complications that were Clavien–Dindo grade III or above occurred in 3 patients (7.3%). There was no anastomotic leakage. The median number of lymph nodes harvested was 46. Our technique was shown to be a safe, feasible, and useful strategy for performance of right hemicolectomy requiring ligation of the MCA in cases of colon cancer. The technique facilitates maximal lymph node dissection. Having obtained favorable outcomes, we look forward to investigation into long-term outcomes.
Published: 2021
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3. Controversies in the Management of Central Nervous System Coccidioidomycosis

Author: George R Thompson, Neil M Ampel, Janis E Blair, Fariba Donovan, Joshua Fierer, John N Galgiani, Arash Heidari, Royce Johnson, Stanley A Shatsky, Christopher M Uchiyama, and David A Stevens
Subjects: Microbiology (medical), Central Nervous System, Infectious Diseases, Antifungal Agents, Coccidioidomycosis, Coccidioides, Humans, Meningitis, Fungal
Abstract: Central nervous system infection with Coccidioides spp. is fatal if untreated and complications occur even when therapy is directed by experienced clinicians. We convened a panel of clinicians experienced in the management of coccidioidal meningitis to summarize current controversies and provide consensus for the management of this difficult infection.
Published: 2022

4. Global parental leave in surgical careers: differences according to gender, geographical regions and surgical career stages

Author: A C H Fung, J M Carvas, J Dziakova, Gianluca Pellino, M Millan, W Kwok, E Samadov, C Teh, Arcangelo Picciariello, Yasuko Maeda, G. H. van Ramshorst, Julio Mayol, N El Feituri, H Ø Kristensen, M U Younis, S Sohrabi, S Au, L Jakobsen, D Clinch, J L Harbjerg, K Eltarhoni, R M Jiménez-Rodríguez, M Uchiyama, G Moeslein, F Ayca Gultekin, Argyrios Ioannidis, S Fleming, J C Sainz Hernandez, H J Ng, C Fysaraki, K M Milto, M Ramser, D Verran, J H-S Wang, Kjetil Søreide, S Pronin, Vittoria Bellato, S Z Kuiper, S Alhomoud, C D Córdoba, A M F Kwok, Gaetano Gallo, Fady Hatem, D Daudu, Neil J. Smart, Surgery, RS: NUTRIM - R2 - Liver and digestive health, Au, S, Bellato, V, Carvas, J M, Córdoba, C D, Daudu, D, Dziakova, J, Eltarhoni, K, El Feituri, N, Fung, A C H, Fysaraki, C, Gallo, G, Gultekin, F Ayca, Harbjerg, J L, Hatem, F, Ioannidis, A, Jakobsen, L, Clinch, D, Kristensen, H Ø, Kuiper, S Z, Kwok, A M F, Kwok, W, Millan, M, Milto, K M, Ng, H J, Pellino, G, Picciariello, A, Pronin, S, van Ramshorst, G H, Ramser, M, Jiménez-Rodríguez, R M, Sainz Hernandez, J C, Samadov, E, Sohrabi, S, Uchiyama, M, Wang, J H-S, Younis, M U, Fleming, S, Alhomoud, S, Mayol, J, Moeslein, G, Smart, N J, Soreide, K, Teh, C, Verran, D, and Maeda, Y
Subjects: Male, operative, Students, Medical, SURGERY, General Surgery, child, consultants, geographic area, parental leave, students, medical, surgical procedures, operative, child care, child care service, paternity, gender, work-life balance, Sex Factor, medical, Surveys and Questionnaires, Medicine, Salary, Gender disparity, Career Choice, students, Financial impact, Work–life balance, WOMEN, Survey research, CHOICE, FEMALE, PREGNANCY, Maternity leave, Parental leave, Human, Adult, Attitude of Health Personnel, Surgeon, Young Adult, Sex Factors, CHILDBEARING, Humans, INTERNET, Surgeons, business.industry, Internship and Residency, Guideline, TRENDS, surgical procedures, Surgery, FATHERS, business, Demography
Abstract: Background There is a lack of information regarding the provision of parental leave for surgical careers. This survey study aims to evaluate the experience of maternity/paternity leave and views on work–life balance globally. Methods A 55-item online survey in 24 languages was distributed via social media as per CHERRIES guideline from February to March 2020. It explored parental leave entitlements, attitude towards leave taking, financial impact, time spent with children and compatibility of parenthood with surgical career. Results Of the 1393 (male : female, 514 : 829) respondents from 65 countries, there were 479 medical students, 349 surgical trainees and 513 consultants. Consultants had less than the recommended duration of maternity leave (43.8 versus 29.1 per cent), no paid maternity (8.3 versus 3.2 per cent) or paternity leave (19.3 versus 11.0 per cent) compared with trainees. Females were less likely to have children than males (36.8 versus 45.6 per cent, P = 0.010) and were more often told surgery is incompatible with parenthood (80.2 versus 59.5 per cent, P Conclusion Surgeons across the globe had inadequate parental leave. Significant gender disparity was seen in multiple aspects.
Published: 2021
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5. Selective azo dye-based colorimetric chemosensor for F−, CH3COO– and PO43−

Author: Caio Henrique dos Santos, Natan M. Uchiyama, and Izilda A. Bagatin
Subjects: chemistry.chemical_classification, Hydrogen bond, Carboxylic acid, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, Phosphate, 01 natural sciences, Medicinal chemistry, Atomic and Molecular Physics, and Optics, 0104 chemical sciences, Analytical Chemistry, chemistry.chemical_compound, chemistry, Phenol, Titration, 0210 nano-technology, Acetonitrile, Instrumentation, Fluoride, Spectroscopy, Benzoic acid
Abstract: Developing anionic receptors is a huge challenge, especially those using hydrogen bonds to interact with the analytes. Azobenzene-derivative selective chemosensor has been evaluated for anion recognition properties. 2‑(4‑Hydroxiazobenzene)benzoic acid (HABA) has two hydrogens groups available for interaction; one is the phenol group and the other is the carboxylic acid group, enabling interaction with cations and anions. Subsequently titrations of chromophore 2‑(4‑hydroxiazobenzene) benzoic acid were performed with cations and anions; however, only the interactions with fluoride, acetate, and phosphate were significant. These data demonstrated the sensitivity of the ligand HABA by these anions, characterized by the displacement of the absorbance bands at 372nm to 491nm in acetonitrile. The association constants found to fluoride, acetate, and phosphate were 1.56×104±0.28, 1.25×104±0.60, and 1.90×104±0.67mol-1dm3 respectively. 1H NMR titrations data confirmed association constants values in agreement with those of UV-Vis, besides showing evidence of the analyte interaction by the hydrogen-bonding of the carboxylic acid group. Overall, UV-Vis limit of detection data for fluoride (1.05×10-7moldm-3), acetate (3.77×10-8moldm-3) and phosphate (3.00×10-8moldm-3), support that HABA can detect low concentration of these anions.
Published: 2019
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6. Application and outcomes of a standardized lymphadenectomy in laparoscopic right hemicolectomy requiring ligation of the middle colic artery

Author: S, Sato, N, Sugano, M, Shiozawa, M, Uchiyama, K, Kazama, A, Kato, T, Oshima, Y, Rino, and M, Masuda
Subjects: Aged, 80 and over, Male, Mesenteric Artery, Inferior, Middle Aged, Mesenteric Artery, Superior, Colonic Neoplasms, Humans, Lymph Node Excision, Laparoscopy, Ligation, Colectomy, Aged, Mesocolon, Retrospective Studies
Abstract: Complete mesocolic excision with central vessel ligation may be important for accurate staging and improving the prognosis of right-sided colon cancer. Although the procedure is often performed laparoscopically, approaching the middle colic artery (MCA) is technically demanding, especially when complete ligation of arteries at their roots is desired. We standardized our laparoscopic approach by establishing the dissection boundary along the superior mesenteric artery to achieve D3 lymphadenectomy in the region of the MCA. The aim of the present study was to evaluate, on the basis of perioperative and short-term oncologic outcomes, the feasibility and safety of our technique METHODS: We conducted a retrospective study on consecutive patients with cancer located at the ascending colon and transverse colon who had laparoscopic right hemicolectomy requiring ligation of the MCA.There were 41 patients (22 males, median age 71 years [range 49-86] years). The median operation time was 285 min, and blood loss volume was 40 mL. Conversion to open surgery was required in 1 case. Complications that were Clavien-Dindo grade III or above occurred in 3 patients (7.3%). There was no anastomotic leakage. The median number of lymph nodes harvested was 46.Our technique was shown to be a safe, feasible, and useful strategy for performance of right hemicolectomy requiring ligation of the MCA in cases of colon cancer. The technique facilitates maximal lymph node dissection. Having obtained favorable outcomes, we look forward to investigation into long-term outcomes.
Published: 2020

7. Anthropometric changes in chronic kidney disease of unknown etiology (CKDU) patients: a single-center longitudinal study in Sri Lanka

Author: N. Nanayakkara, Yu Koyama, R. Chandrajith, M. Uchiyama, U. Shimizu, S. Wimalasiri, and H.M. Abeywickrama
Subjects: Longitudinal study, Pediatrics, medicine.medical_specialty, Nutrition and Dietetics, business.industry, Endocrinology, Diabetes and Metabolism, Anthropometry, medicine.disease, Single Center, medicine, Etiology, Sri lanka, business, Kidney disease
Published: 2021
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8. Genomic analysis reveals low tumor mutation burden which may be associated with GNAQ/11 alteration in a series of primary leptomeningeal melanomas

Author: Christopher M. Uchiyama, Michael P. Kosty, Kathryn Bollin, Brian Hinds, Sherri Z. Millis, and Shannon Fortin Ensign
Subjects: 0301 basic medicine, Neuroblastoma RAS viral oncogene homolog, medicine.medical_treatment, Central nervous system, Dermatology, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Meningeal Neoplasms, Medicine, Humans, Genetic Predisposition to Disease, Gene, Genetic Association Studies, Aged, Mutation, business.industry, Melanoma, Immunotherapy, Genomics, medicine.disease, GTP-Binding Protein alpha Subunits, 030104 developmental biology, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Cohort, Cancer research, GTP-Binding Protein alpha Subunits, Gq-G11, Female, business, Tomography, X-Ray Computed, GNAQ
Abstract: Primary central nervous system melanoma is rare and characterized by a variable prognosis, and no current treatment guidelines exist. We describe the clinical course of a 70-year-old female patient diagnosed with primary leptomeningeal melanoma (LMN) whose case represents the diagnostic and management challenges of this tumor. Targeted genomic sequencing of 315 genes from this tumor revealed GNAQ Q209L mutation and low (4 mutations/Megabase) tumor mutation burden (TMB). Wild-type NRAS, KIT, and BRAF were also observed. A cohort of 4,787 melanomas was subsequently analyzed to identify additional primary central nervous system melanomas, of which 10 additional tumors met pathologic criteria (0.21% of total melanoma cohort). These tumors were genomically assessed according to the same targeted sequencing panel, and 6 of the tumors were also found to harbor a GNAQ mutation. All 10 tumors had low (less than or equal to 2 mutations/Megabase) TMB indicating a potential trend between G-protein-coupled receptor (GPCR) alterations and low TMB in LMNs. GPCR alterations were found to significantly correlate with TMB across the cohort of 4,787 melanomas, supporting this potential finding in the limited LMN subset.
Published: 2019

9. Association between chronic kidney disease of unknown etiology (CKDU) and anthropometric measures and indices: A case-control study in Sri Lanka

Author: M. Uchiyama, H.M. Abeywickrama, Yu Koyama, U. Shimizu, S. Wimalasiri, N. Nanayakkara, and R. Chandrajith
Subjects: Pediatrics, medicine.medical_specialty, Nutrition and Dietetics, business.industry, Endocrinology, Diabetes and Metabolism, Case-control study, medicine, Etiology, Sri lanka, Anthropometry, medicine.disease, business, Kidney disease
Published: 2020
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10. Selective azo dye-based colorimetric chemosensor for F

Author: Caio Henrique, Dos Santos, Natan M, Uchiyama, and Izilda A, Bagatin
Abstract: Developing anionic receptors is a huge challenge, especially those using hydrogen bonds to interact with the analytes. Azobenzene-derivative selective chemosensor has been evaluated for anion recognition properties. 2‑(4‑Hydroxiazobenzene)benzoic acid (HABA) has two hydrogens groups available for interaction; one is the phenol group and the other is the carboxylic acid group, enabling interaction with cations and anions. Subsequently titrations of chromophore 2‑(4‑hydroxiazobenzene) benzoic acid were performed with cations and anions; however, only the interactions with fluoride, acetate, and phosphate were significant. These data demonstrated the sensitivity of the ligand HABA by these anions, characterized by the displacement of the absorbance bands at 372nm to 491nm in acetonitrile. The association constants found to fluoride, acetate, and phosphate were 1.56×10
Published: 2018

11. Rikkunshito (TJ-43) Improved Reduction of Food Intake in a Murine Cardiac Transplantation Model

Author: Enzhi Yin, M. Niimi, and M. Uchiyama
Subjects: Male, Food intake, medicine.medical_specialty, media_common.quotation_subject, 0211 other engineering and technologies, 02 engineering and technology, Gastroenterology, 03 medical and health sciences, Eating, Mice, 0302 clinical medicine, Oral administration, Internal medicine, 021105 building & construction, Medicine, Animals, Postoperative Period, media_common, Transplantation, Cardiac allograft, business.industry, Appetite Regulation, Weight change, Appetite, Mice, Inbred C57BL, 030220 oncology & carcinogenesis, Vomiting, Mice, Inbred CBA, Heart Transplantation, Surgery, Female, Gastritis, medicine.symptom, business, Drugs, Chinese Herbal, Phytotherapy
Abstract: Rikkunshito (TJ-43), an eight-component traditional Japanese herbal medicine, has been used in clinics for gastritis, vomiting, and appetite loss. We investigated the effects of TJ-43 on the amelioration of appetite loss in the surgical-exposed model of murine cardiac allograft transplantation. CBA mice underwent transplantation of a CBA (syngeneic group) or C57BL/6 heart (allogeneic group) and received oral administration of 2 g/kg/d of TJ-43 from the day of transplantation until 7 days afterward. The amount of food intake (FI) and weight change after operation were recorded from 1 to 28 postoperative days. The allogeneic group had less average amounts of FI for 1 week compared with the syngeneic group (FI was 1.90 ± 0.43 g and 2.66 ± 0.46 g, respectively). Average FIs between the syngeneic and allogeneic groups with TJ-43 for 1 week were 2.36 ± 0.44 g and 2.30 ± 0.13 g, respectively, and those with distilled water were 2.66 ± 0.46 g and 1.90 ± 0.43 g, respectively, suggesting that exposure with TJ-43 tended to ameliorate the reduction of FI. Similarly, the effect on the amelioration of average FI in syngeneic and allogeneic groups exposed for 2 weeks was confirmed. However, exposure to with TJ-43 had no effects on FI after 4 weeks. TJ-43 could prevent reduction of average FI induced by the surgical-exposed model of murine cardiac allograft transplantation.
Published: 2017

12. Induction of Regulatory CD4

Author: E, Yin, M, Uchiyama, and M, Niimi
Subjects: CD4-Positive T-Lymphocytes, Male, Myocardium, Heart, Allografts, Adoptive Transfer, T-Lymphocytes, Regulatory, Major Histocompatibility Complex, Mice, Inbred C57BL, Mice, Japan, Mice, Inbred CBA, Animals, Heart Transplantation, Drugs, Chinese Herbal
Abstract: Shigyakusan (also known as Tsumura Japan [TJ]-35) is composed of peony, bitter orange, licorice, and Bupleuri radix is used for cholecystitis and gastritis as an anti-inflammatory agent. We investigated the effect of TJ-35 on alloimmune response in a murine heart transplantation model. CBA mice that underwent transplantation of a C57BL/6 (B6) heart were assigned to four groups: no treatment, TJ-35-exposed, each component-exposed, or each component missing-exposed. The four groups above each received oral administration of TJ-35, each component, or TJ-35 with each component missing from the day of transplantation until 7 days, respectively. Untreated CBA recipients rejected B6 cardiac grafts acutely (median survival time [MST], 7 days). TJ-35-exposed CBA recipients had significantly prolonged B6 allograft survival (MST, 20.5 days). However, MSTs of CBA recipients that had been administered each component and TJ-35 with each component missing did not reach that of TJ-35-exposed recipients. Adoptive transfer of CD4
Published: 2017

13. Effects of Repeated Training on Controlled Force Exertion and Retention in Dominant and Nondominant Hands

Author: Shinichi Demura, H. Kubota, Kenji Takahashi, and M. Uchiyama
Subjects: Economics and Econometrics, medicine.medical_specialty, Significant difference, Motor control, Forestry, Laterality, Materials Chemistry, Media Technology, Physical therapy, medicine, Exertion, Analysis of variance, Motor learning, Psychology, Practice trial, Young male
Abstract: This study aimed to examine the effects of repeated training on the controlled force exertion (CFE) test and retention in dominant and nondominant hands. The subjects were 10 young males (mean age, 21.8 ± 1.4 years). The CFE test was used as the repeated training task and performed 5 days per week over 3 weeks (a total of 15 times). The exertion value of the subjects’ handgrip strengths was matched to constantly changing demand values for 40 s. Three trials were performed after one practice trial. The difference between the demand value and the grip exertion value was used as the evaluation parameter, referred to as the CFE error, and the mean of the second and third trials was used for analysis. The initial and final values for the dominant and nondominant hands and those taken one month after the repeated training task were used for analysis. A two-way analysis of variance revealed that the final CFE errors for both hands were significantly smaller than the initial CFE errors, and no significant difference was found between the dominant and nondominant hands in the final tests. In addition, after one month, the CFE errors for both hands were significantly smaller than the initial CFE errors and were significantly smaller in the dominant hand than in the nondominant hand. Repeated training in controlled force exertion improves CFE in both the dominant and nondominant hands, but the dominant and nondominant hands differ in retention of the effects.
Published: 2014
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14. Subjective taste difference between Japanese and Sri Lankan students: Effect of food composition, nationality and serum zinc level

Author: A. Iijima, A. Ohnuma, R. Takanarita, A. Okuda, E. Yamada, Yu Koyama, M. Uchiyama, M. Fujimori, Y. Hirasawa, R. Saito, and N. Onoma
Subjects: Taste, Nutrition and Dietetics, Traditional medicine, business.industry, Nationality, Medicine, Serum zinc level, Food composition data, Critical Care and Intensive Care Medicine, business
Published: 2018
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15. Efficacy and safety of isatuximab plus pomalidomide and dexamethasone in East Asian patients with relapsed/refractory multiple myeloma: A subgroup analysis of ICARIA-MM study

Author: Jin Seok Kim, Morio Matsumoto, S.-Y. Huang, Y.I. Koh, F. Campana, Hitomi Kaneko, Je-Hwan Lee, Kihyun Kim, Chihiro Shimazaki, Shih-Peng Yeh, Takashi Ikeda, M. Uchiyama, Kazutaka Sunami, Kazuhito Suzuki, T.-L. Lin, Satoshi Iyama, Shinsuke Iida, K. Tada, C.G. Min, and Ming Chung Wang
Subjects: 0301 basic medicine, medicine.medical_specialty, Entire population, education.field_of_study, business.industry, Population, Refractory Multiple Myeloma, Subgroup analysis, Hematology, Pomalidomide, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Oncology, 030220 oncology & carcinogenesis, Family medicine, Relapsed refractory, Medicine, In patient, business, Until Disease Progression, education, medicine.drug
Abstract: Background The phase 3 ICARIA study demonstrated that isatuximab (Isa) plus pomalidomide and dexamethasone (Pd) significantly improved progression free survival (PFS) compared with Pd in patients (pts) with relapsed/refractory multiple myeloma (RRMM) (HR = 0.596, 95%CI 0.44-0.81, P = 0.001). We evaluated the efficacy/safety of Isa-Pd in the East Asian pts (13 Japanese, 9 Korean and 14 Taiwanese pts) of ICARIA. Methods RRMM pts who had received ≥2 prior lines of therapies, including lenalidomide (len) and at least a proteasome inhibitor (PI), and were refractory to their last therapy were enrolled. Pts were randomized into either Isa-Pd arm who received Isa 10 mg/kg IV weekly for the first 4 weeks (wks) followed by biweekly or Pd arm, and all pts received Pom (4mg PO days 1-21) and dex (40mg [20mg if older than 75 yrs] PO or IV weekly) in 28 day cycle until disease progression or unacceptable toxicity. Results Data from 36 East Asian pts (21 Isa-Pd, 15 Pd) including Japanese pts (9 Isa-Pd, 4 Pd) were analyzed. Patient’s characteristics were similar in the East Asian subgroup and the entire population of ICARIA study (n = 307). Of these pts, median age: 65 (range, 41-85) yrs; median prior lines of therapy: 3 (range, 2-7); 91.7% and 69.4% were refractory to len and PI, respectively; and 13.9% had high-risk cytogenetics. After median follow-up of 11.6 months, median PFS was not reached yet in Isa-Pd arm and was 7.9 months in Pd arm (HR 0.517 [95% CI 0.19-1.39]). ORR (≥PR) was 71.4% in Isa-Pd arm 60% in Pd arm. The VGPR rate or better was 61.9% and 13.3% in Isa-Pd and Pd arm, respectively. Median time to first response was 32 days and 59 days for Isa-Pd and Pd arm, respectively. Grade ≥3 AEs were observed in 90.5% and 73.3% pts in Isa-Pd and Pd arm, respectively and which caused 9.5% pts in the Isa-Pd arm and 0 % in Pd arm to discontinue their treatment. Infusion associated reactions were reported in 57.1% pts receiving Isa-Pd but none of them were grade 3-4. Conclusions This subgroup analysis of ICARIA demonstrates that the efficacy and safety of Isa-Pd in East Asian population, including Japanese pts, are comparable with the entire population of ICARIA. Isa-Pd is a novel treatment option for East Asian pts with RRMM. Clinical trial identification Clinical trial information: NCT02990338. Legal entity responsible for the study Sanofi. Funding Sanofi. Disclosure K. Sunami: Speaker Bureau / Expert testimony: Sanofi; Speaker Bureau / Expert testimony: Novartis; Speaker Bureau / Expert testimony: GlaxoSmithKline; Speaker Bureau / Expert testimony: Janssen Pharmaceutical. M. Matsumoto: Speaker Bureau / Expert testimony: Celgene Co., LTD; Speaker Bureau / Expert testimony: Janssen Pharmaceutical Co., LTD; Speaker Bureau / Expert testimony: Bristol-Myers Squibb K.K.; Speaker Bureau / Expert testimony: Ono Pharmaceutical Co., LTD. C. Shimazaki: Speaker Bureau / Expert testimony: Ono Pharmaceutical Co. Ltd.; Speaker Bureau / Expert testimony: Celgen Co. Ltd.; Speaker Bureau / Expert testimony: Fujimoto Pharmaceutical Co. Ltd. F. Campana: Full / Part-time employment: Sanofi. K. Tada: Full / Part-time employment: Sanofi. S. Iida: Speaker Bureau / Expert testimony: Ono; Speaker Bureau / Expert testimony: Janssen; Speaker Bureau / Expert testimony: Celgene; Speaker Bureau / Expert testimony: Bristol-Myers Squibb; Speaker Bureau / Expert testimony: Takeda; Speaker Bureau / Expert testimony: Novartis; Speaker Bureau / Expert testimony: Daiichi-Sankyo; Speaker Bureau / Expert testimony: Chugai; Speaker Bureau / Expert testimony: Kyowa Hakko Kirin; Speaker Bureau / Expert testimony: Sanofi; Speaker Bureau / Expert testimony: MSD; Speaker Bureau / Expert testimony: Daiichi Sankyo; Speaker Bureau / Expert testimony: Gilead; Speaker Bureau / Expert testimony: AbbVie. K. Suzuki: Speaker Bureau / Expert testimony: Janssen; Speaker Bureau / Expert testimony: Novartis; Speaker Bureau / Expert testimony: Celgene; Speaker Bureau / Expert testimony: Ono; Speaker Bureau / Expert testimony: Fujimoto; Speaker Bureau / Expert testimony: Takeda; Speaker Bureau / Expert testimony: Sumitomo Dainippon ; Speaker Bureau / Expert testimony: BMS; Speaker Bureau / Expert testimony: Sanofi. All other authors have declared no conflicts of interest.
Published: 2019
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16. PT01.6: Sketetal Muscle Index at ICU (Intensive Care Unit) Admission is Valid for Predicting the Progression of ICU-Acquired Weakness (ICU-AW) for Septic Patients

Author: Yu Koyama, Y. Kikuchi, H.M. Abeywickrama, H. Endoh, S. Sakai, M. Nitta, K. Ohashi, E. Yamada, T. Honda, Y. Mitobe, and M. Uchiyama
Subjects: medicine.medical_specialty, Nutrition and Dietetics, Index (economics), business.industry, law, Emergency medicine, Medicine, Icu acquired weakness, Critical Care and Intensive Care Medicine, business, Intensive care unit, law.invention
Published: 2019
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17. PF623 PHASE 1/2 STUDY OF ISATUXIMAB MONOTHERAPY FOR RELAPSED AND/OR REFRACTORY MULTIPLE MYELOMA IN JAPANESE PATIENTS

Author: D. Maruyama, T. Kiguchi, Takashi Ikeda, K. Sunami, S. Iida, Satoshi Iyama, H. Asaoku, M. Uchiyama, Chihiro Shimazaki, M. Ri, Hitomi Kaneko, H. Shibayama, Morio Matsumoto, H. Murakami, K. Suzuki, K. Ishizawa, Hiroyuki Takamatsu, K. Tada, and T. Sasaki
Subjects: Oncology, Isatuximab, medicine.medical_specialty, business.industry, Internal medicine, Phase (matter), medicine, Refractory Multiple Myeloma, Hematology, business
Published: 2019
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18. Yogurt Feeding Induced the Prolongation of Fully Major Histocompatibility Complex-Mismatched Murine Cardiac Graft Survival by Induction of CD4

Author: M, Uchiyama, E, Yin, T, Yanagisawa, X, Jin, M, Hara, S, Matsuyama, T, Imazuru, K, Uchida, M, Kawamura, and M, Niimi
Subjects: CD4-Positive T-Lymphocytes, Major Histocompatibility Complex, Mice, Inbred C57BL, Mice, Graft Survival, Mice, Inbred CBA, Animals, Heart Transplantation, Animal Nutritional Physiological Phenomena, Forkhead Transcription Factors, Pilot Projects, Yogurt
Abstract: Yogurt is a nutrient-rich food and the beneficial effects of yogurt on both health and immunomodulatory effects are well documented. In this pilot study, we investigated the effects of commercially produced yogurt R-1 on alloimmune responses in a murine cardiac transplantation model. The R-1 is produced by Meiji Co., Ltd., and contains live and active lactic acid bacteria (lactobacillus bulgaricus OLL1073R-1) mainly. CBA (H2
Published: 2016

19. Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Author: Klionsky, D.J. Abdelmohsen, K. Abe, A. Abedin, M.J. Abeliovich, H. Arozena, A.A. Adachi, H. Adams, C.M. Adams, P.D. Adeli, K. Adhihetty, P.J. Adler, S.G. Agam, G. Agarwal, R. Aghi, M.K. Agnello, M. Agostinis, P. Aguilar, P.V. Aguirre-Ghiso, J. Airoldi, E.M. Ait-Si-Ali, S. Akematsu, T. Akporiaye, E.T. Al-Rubeai, M. Albaiceta, G.M. Albanese, C. Albani, D. Albert, M.L. Aldudo, J. Algül, H. Alirezaei, M. Alloza, I. Almasan, A. Almonte-Beceril, M. Alnemri, E.S. Alonso, C. Altan-Bonnet, N. Altieri, D.C. Alvarez, S. Alvarez-Erviti, L. Alves, S. Amadoro, G. Amano, A. Amantini, C. Ambrosio, S. Amelio, I. Amer, A.O. Amessou, M. Amon, A. An, Z. Anania, F.A. Andersen, S.U. Andley, U.P. Andreadi, C.K. Andrieu-Abadie, N. Anel, A. Ann, D.K. Anoopkumar-Dukie, S. Antonioli, M. Aoki, H. Apostolova, N. Aquila, S. Aquilano, K. Araki, K. Arama, E. Aranda, A. Araya, J. Arcaro, A. Arias, E. Arimoto, H. Ariosa, A.R. Armstrong, J.L. Arnould, T. Arsov, I. Asanuma, K. Askanas, V. Asselin, E. 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Xia, W. Xia, Y. Xiao, H. Xiao, J. Xiao, S. Xiao, W. Xie, C.-M. Xie, Z. Xie, Z. Xilouri, M. Xiong, Y. Xu, C. Xu, C. Xu, F. Xu, H. Xu, H. Xu, J. Xu, J. Xu, J. Xu, L. Xu, X. Xu, Y. Xu, Y. Xu, Z.-X. Xu, Z. Xue, Y. Yamada, T. Yamamoto, A. Yamanaka, K. Yamashina, S. Yamashiro, S. Yan, B. Yan, B. Yan, X. Yan, Z. Yanagi, Y. Yang, D.-S. Yang, J.-M. Yang, L. Yang, M. Yang, P.-M. Yang, P. Yang, Q. Yang, W. Yang, W.Y. Yang, X. Yang, Y. Yang, Y. Yang, Z. Yang, Z. Yao, M.-C. Yao, P.J. Yao, X. Yao, Z. Yao, Z. Yasui, L.S. Ye, M. Yedvobnick, B. Yeganeh, B. Yeh, E.S. Yeyati, P.L. Yi, F. Yi, L. Yin, X.-M. Yip, C.K. Yoo, Y.-M. Yoo, Y.H. Yoon, S.-Y. Yoshida, K.-I. Yoshimori, T. Young, K.H. Yu, H. Yu, J.J. Yu, J.-T. Yu, J. Yu, L. Yu, W.H. Yu, X.-F. Yu, Z. Yuan, J. Yuan, Z.-M. Yue, B.Y.J.T. Yue, J. Yue, Z. Zacks, D.N. Zacksenhaus, E. Zaffaroni, N. Zaglia, T. Zakeri, Z. Zecchini, V. Zeng, J. Zeng, M. Zeng, Q. Zervos, A.S. Zhang, D.D. Zhang, F. Zhang, G. Zhang, G.-C. Zhang, H. Zhang, H. Zhang, H. Zhang, J. Zhang, J. Zhang, J. Zhang, J.-P. Zhang, L. Zhang, L. Zhang, L. Zhang, M.-Y. Zhang, X. Zhang, X.D. Zhang, Y. Zhang, Y. Zhang, Y. Zhang, Y. Zhang, Y. Zhao, M. Zhao, W.-L. Zhao, X. Zhao, Y.G. Zhao, Y. Zhao, Y. Zhao, Y.-X. Zhao, Z. Zhao, Z.J. Zheng, D. Zheng, X.-L. Zheng, X. Zhivotovsky, B. Zhong, Q. Zhou, G.-Z. Zhou, G. Zhou, H. Zhou, S.-F. Zhou, X.-J. Zhu, H. Zhu, H. Zhu, W.-G. Zhu, W. Zhu, X.-F. Zhu, Y. Zhuang, S.-M. Zhuang, X. Ziparo, E. Zois, C.E. Zoladek, T. Zong, W.-X. Zorzano, A. Zughaier, S.M.
Published: 2016

20. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Author: Klionsky, D.J. Abdelmohsen, K. Abe, A. Abedin, M.J. Abeliovich, H. Arozena, A.A. Adachi, H. Adams, C.M. Adams, P.D. Adeli, K. Adhihetty, P.J. Adler, S.G. Agam, G. Agarwal, R. Aghi, M.K. Agnello, M. Agostinis, P. Aguilar, P.V. Aguirre-Ghiso, J. Airoldi, E.M. Ait-Si-Ali, S. Akematsu, T. Akporiaye, E.T. Al-Rubeai, M. Albaiceta, G.M. Albanese, C. Albani, D. Albert, M.L. Aldudo, J. Algül, H. Alirezaei, M. Alloza, I. Almasan, A. Almonte-Beceril, M. Alnemri, E.S. Alonso, C. Altan-Bonnet, N. Altieri, D.C. Alvarez, S. Alvarez-Erviti, L. Alves, S. Amadoro, G. Amano, A. Amantini, C. Ambrosio, S. Amelio, I. Amer, A.O. Amessou, M. Amon, A. An, Z. Anania, F.A. Andersen, S.U. Andley, U.P. Andreadi, C.K. Andrieu-Abadie, N. Anel, A. Ann, D.K. Anoopkumar-Dukie, S. Antonioli, M. Aoki, H. Apostolova, N. Aquila, S. Aquilano, K. Araki, K. Arama, E. Aranda, A. Araya, J. Arcaro, A. Arias, E. Arimoto, H. Ariosa, A.R. Armstrong, J.L. Arnould, T. Arsov, I. Asanuma, K. Askanas, V. Asselin, E. Atarashi, R. Atherton, S.S. Atkin, J.D. Attardi, L.D. Auberger, P. Auburger, G. Aurelian, L. Autelli, R. Avagliano, L. Avantaggiati, M.L. Avrahami, L. Azad, N. Awale, S. Bachetti, T. Backer, J.M. Bae, D.-H. Bae, J.-S. Bae, O.-N. Bae, S.H. Baehrecke, E.H. Baek, S.-H. Baghdiguian, S. Bagniewska-Zadworna, A. Bai, H. Bai, J. Bai, X.-Y. Bailly, Y. Balaji, K.N. Balduini, W. Ballabio, A. Balzan, R. Banerjee, R. Bánhegyi, G. Bao, H. Barbeau, B. Barrachina, M.D. Barreiro, E. Bartel, B. Bartolomé, A. Bassham, D.C. Bassi, M.T. Bast, R.C., Jr. Basu, A. Batista, M.T. Batoko, H. Battino, M. Bauckman, K. Baumgarner, B.L. Bayer, K.U. Beale, R. Beaulieu, J.-F. Beck, G.R., Jr. Becker, C. Beckham, J.D. Bédard, P.-A. Bednarski, P.J. Begley, T.J. Behl, C. Behrends, C. Behrens, G.M.N. Behrns, K.E. Bejarano, E. Belaid, A. Belleudi, F. Bénard, G. Berchem, G. Bergamaschi, D. Bergami, M. Berkhout, B. Berliocchi, L. Bernard, A. Bernard, M. Bernassola, F. Bertolotti, A. Bess, A.S. Besteiro, S. Bettuzzi, S. Bhalla, S. Bhattacharyya, S. Bhutia, S.K. Biagosch, C. Bianchi, M.W. Biard-Piechaczyk, M. Billes, V. Bincoletto, C. Bingol, B. Bird, S.W. Bitoun, M. Bjedov, I. Blackstone, C. Blanc, L. Blanco, G.A. Blomhoff, H.K. Boada-Romero, E. Böckler, S. Boes, M. Boesze-Battaglia, K. Boise, L.H. Bolino, A. Boman, A. Bonaldo, P. Bordi, M. Bosch, J. Botana, L.M. Botti, J. Bou, G. Bouché, M. Bouchecareilh, M. Boucher, M.-J. Boulton, M.E. Bouret, S.G. Boya, P. Boyer-Guittaut, M. Bozhkov, P.V. Brady, N. Braga, V.M.M. Brancolini, C. Braus, G.H. Bravo-San-Pedro, J.M. Brennan, L.A. Bresnick, E.H. Brest, P. Bridges, D. Bringer, M.-A. Brini, M. Brito, G.C. Brodin, B. Brookes, P.S. Brown, E.J. Brown, K. Broxmeyer, H.E. Bruhat, A. Brum, P.C. Brumell, J.H. Brunetti-Pierri, N. Bryson-Richardson, R.J. Buch, S. Buchan, A.M. Budak, H. Bulavin, D.V. Bultman, S.J. Bultynck, G. Bumbasirevic, V. Burelle, Y. Burke, R.E. Burmeister, M. Bütikofer, P. Caberlotto, L. Cadwell, K. Cahova, M. Cai, D. Cai, J. Cai, Q. Calatayud, S. Camougrand, N. Campanella, M. Campbell, G.R. Campbell, M. Campello, S. Candau, R. Caniggia, I. Cantoni, L. Cao, L. Caplan, A.B. Caraglia, M. Cardinali, C. Cardoso, S.M. Carew, J.S. Carleton, L.A. Carlin, C.R. Carloni, S. Carlsson, S.R. Carmona-Gutierrez, D. Carneiro, L.A.M. Carnevali, O. Carra, S. Carrier, A. Carroll, B. Casas, C. Casas, J. Cassinelli, G. Castets, P. Castro-Obregon, S. Cavallini, G. Ceccherini, I. Cecconi, F. Cederbaum, A.I. Ceña, V. Cenci, S. Cerella, C. Cervia, D. Cetrullo, S. Chaachouay, H. Chae, H.-J. Chagin, A.S. Chai, C.-Y. Chakrabarti, G. Chamilos, G. Chan, E.Y.W. Chan, M.T.V. Chandra, D. Chandra, P. Chang, C.-P. Chang, R.C.-C. Chang, T.Y. Chatham, J.C. Chatterjee, S. Chauhan, S. Che, Y. Cheetham, M.E. Cheluvappa, R. Chen, C.-J. Chen, G. Chen, G.-C. Chen, G. Chen, H. Chen, J.W. Chen, J.-K. Chen, M. Chen, M. Chen, P. Chen, Q. Chen, Q. Chen, S.-D. Chen, S. Chen, S.S.-L. Chen, W. Chen, W.-J. Chen, W.Q. Chen, W. Chen, X. Chen, Y.-H. Chen, Y.-G. Chen, Y. Chen, Y. Chen, Y. Chen, Y.-J. Chen, Y.-Q. Chen, Y. Chen, Z. Chen, Z. Cheng, A. Cheng, C.H.K. Cheng, H. Cheong, H. Cherry, S. Chesney, J. Cheung, C.H.A. Chevet, E. Chi, H.C. Chi, S.-G. Chiacchiera, F. Chiang, H.-L. Chiarelli, R. Chiariello, M. Chieppa, M. Chin, L.-S. Chiong, M. Chiu, G.N.C. Cho, D.-H. Cho, S.-G. Cho, W.C. Cho, Y.-Y. Cho, Y.-S. Choi, A.M.K. Choi, E.-J. Choi, E.-K. Choi, J. Choi, M.E. Choi, S.-I. Chou, T.-F. Chouaib, S. Choubey, D. Choubey, V. Chow, K.-C. Chowdhury, K. Chu, C.T. Chuang, T.-H. Chun, T. Chung, H. Chung, T. Chung, Y.-L. Chwae, Y.-J. Cianfanelli, V. Ciarcia, R. Ciechomska, I.A. Ciriolo, M.R. Cirone, M. Claerhout, S. Clague, M.J. Clària, J. Clarke, P.G.H. Clarke, R. Clementi, E. Cleyrat, C. Cnop, M. Coccia, E.M. Cocco, T. Codogno, P. Coers, J. Cohen, E.E.W. Colecchia, D. Coletto, L. Coll, N.S. Colucci-Guyon, E. Comincini, S. Condello, M. Cook, K.L. Coombs, G.H. Cooper, C.D. Cooper, J.M. Coppens, I. Corasaniti, M.T. Corazzari, M. Corbalan, R. Corcelle-Termeau, E. Cordero, M.D. Corral-Ramos, C. Corti, O. Cossarizza, A. Costelli, P. Costes, S. Cotman, S.L. Coto-Montes, A. Cottet, S. Couve, E. Covey, L.R. Cowart, L.A. Cox, J.S. Coxon, F.P. Coyne, C.B. Cragg, M.S. Craven, R.J. Crepaldi, T. Crespo, J.L. Criollo, A. Crippa, V. Cruz, M.T. Cuervo, A.M. Cuezva, J.M. Cui, T. Cutillas, P.R. Czaja, M.J. Czyzyk-Krzeska, M.F. Dagda, R.K. Dahmen, U. Dai, C. Dai, W. Dai, Y. Dalby, K.N. Valle, L.D. Dalmasso, G. D'amelio, M. Damme, M. Darfeuille-Michaud, A. Dargemont, C. Darley-Usmar, V.M. Dasarathy, S. Dasgupta, B. Dash, S. Dass, C.R. Davey, H.M. Davids, L.M. Dávila, D. Davis, R.J. Dawson, T.M. Dawson, V.L. Daza, P. de Belleroche, J. de Figueiredo, P. de Figueiredo, R.C.B.Q. de la Fuente, J. De Martino, L. De Matteis, A. De Meyer, G.R.Y. De Milito, A. De Santi, M. de Souza, W. De Tata, V. De Zio, D. Debnath, J. Dechant, R. Decuypere, J.-P. Deegan, S. Dehay, B. Del Bello, B. Del Re, D.P. Delage-Mourroux, R. Delbridge, L.M.D. Deldicque, L. Delorme-Axford, E. Deng, Y. Dengjel, J. Denizot, M. Dent, P. Der, C.J. Deretic, V. Derrien, B. Deutsch, E. Devarenne, T.P. Devenish, R.J. Di Bartolomeo, S. Di Daniele, N. Di Domenico, F. Di Nardo, A. Di Paola, S. Di Pietro, A. Di Renzo, L. Di Antonio, A. Díaz-Araya, G. Díaz-Laviada, I. Diaz-Meco, M.T. Diaz-Nido, J. Dickey, C.A. Dickson, R.C. Diederich, M. Digard, P. Dikic, I. Dinesh-Kumar, S.P. Ding, C. Ding, W.-X. Ding, Z. Dini, L. Distler, J.H.W. Diwan, A. Djavaheri-Mergny, M. Dmytruk, K. Dobson, R.C.J. Doetsch, V. Dokladny, K. Dokudovskaya, S. Donadelli, M. Dong, X.C. Dong, X. Dong, Z. Donohue, T.M., Jr. Donohue-Jr, T.M. Doran, K.S. D'orazi, G. Dorn, G.W., II Dosenko, V. Dridi, S. Drucker, L. Du, J. Du, L.-L. Du, L. du Toit, A. Dua, P. Duan, L. Duann, P. Dubey, V.K. Duchen, M.R. Duchosal, M.A. Duez, H. Dugail, I. Dumit, V.I. Duncan, M.C. Dunlop, E.A. Dunn, W.A., Jr. Dupont, N. Dupuis, L. Durán, R.V. Durcan, T.M. Duvezin-Caubet, S. Duvvuri, U. Eapen, V. Ebrahimi-Fakhari, D. Echard, A. Eckhart, L. Edelstein, C.L. Edinger, A.L. Eichinger, L. Eisenberg, T. Eisenberg-Lerner, A. Eissa, N.T. El-Deiry, W.S. El-Khoury, V. Elazar, Z. Eldar-Finkelman, H. Elliott, C.J.H. Emanuele, E. Emmenegger, U. Engedal, N. Engelbrecht, A.-M. Engelender, S. Enserink, J.M. Erdmann, R. Erenpreisa, J. Eri, R. Eriksen, J.L. Erman, A. Escalante, R. Eskelinen, E.-L. Espert, L. Esteban-Martínez, L. Evans, T.J. Fabri, M. Fabrias, G. Fabrizi, C. Facchiano, A. Færgeman, N.J. Faggioni, A. Fairlie, W.D. Fan, C. Fan, D. Fan, J. Fang, S. Fanto, M. Fanzani, A. Farkas, T. Faure, M. Favier, F.B. Fearnhead, H. Federici, M. Fei, E. Felizardo, T.C. Feng, H. Feng, Y. Feng, Y. Ferguson, T.A. Fernández, Á.F. Fernandez-Barrena, M.G. Fernandez-Checa, J.C. Fernández-López, A. Fernandez-Zapico, M.E. Feron, O. Ferraro, E. Ferreira-Halder, C.V. Fesus, L. Feuer, R. Fiesel, F.C. Filippi-Chiela, E.C. Filomeni, G. Fimia, G.M. Fingert, J.H. Finkbeiner, S. Finkel, T. Fiorito, F. Fisher, P.B. Flajolet, M. Flamigni, F. Florey, O. Florio, S. Floto, R.A. Folini, M. Follo, C. Fon, E.A. Fornai, F. Fortunato, F. Fraldi, A. Franco, R. Francois, A. François, A. Frankel, L.B. Fraser, I.D.C. Frey, N. Freyssenet, D.G. Frezza, C. Friedman, S.L. Frigo, D.E. Fu, D. Fuentes, J.M. Fueyo, J. Fujitani, Y. Fujiwara, Y. Fujiya, M. Fukuda, M. Fulda, S. Fusco, C. Gabryel, B. Gaestel, M. Gailly, P. Gajewska, M. Galadari, S. Galili, G. Galindo, I. Galindo, M.F. Galliciotti, G. Galluzzi, L. Galluzzi, L. Galy, V. Gammoh, N. Gandy, S. Ganesan, A.K. Ganesan, S. Ganley, I.G. Gannagé, M. Gao, F.-B. Gao, F. Gao, J.-X. Nannig, L.G. Véscovi, E.G. Garcia-Macía, M. Garcia-Ruiz, C. Garg, A.D. Garg, P.K. Gargini, R. Gassen, N.C. Gatica, D. Gatti, E. Gavard, J. Gavathiotis, E. Ge, L. Ge, P. Ge, S. Gean, P.-W. Gelmetti, V. Genazzani, A.A. Geng, J. Genschik, P. Gerner, L. Gestwicki, J.E. Gewirtz, D.A. Ghavami, S. Ghigo, E. Ghosh, D. Giammarioli, A.M. Giampieri, F. Giampietri, C. Giatromanolaki, A. Gibbings, D.J. Gibellini, L. Gibson, S.B. Ginet, V. Giordano, A. Giorgini, F. Giovannetti, E. Girardin, S.E. Gispert, S. Giuliano, S. Gladson, C.L. Glavic, A. Gleave, M. Godefroy, N. Gogal, R.M., Jr. Gokulan, K. Goldman, G.H. Goletti, D. Goligorsky, M.S. Gomes, A.V. Gomes, L.C. Gomez, H. Gomez-Manzano, C. Gómez-Sánchez, R. Gonçalves, D.A.P. Goncu, E. Gong, Q. Gongora, C. Gonzalez, C.B. Gonzalez-Alegre, P. Gonzalez-Cabo, P. González-Polo, R.A. Goping, I.S. Gorbea, C. Gorbunov, N.V. Goring, D.R. Gorman, A.M. Gorski, S.M. Goruppi, S. Goto-Yamada, S. Gotor, C. Gottlieb, R.A. Gozes, I. Gozuacik, D. Graba, Y. Graef, M. Granato, G.E. Grant, G.D. Grant, S. Gravina, G.L. Green, D.R. Greenhough, A. Greenwood, M.T. Grimaldi, B. Gros, F. Grose, C. Groulx, J.-F. Gruber, F. Grumati, P. Grune, T. Guan, J.-L. Guan, K.-L. Guerra, B. Guillen, C. Gulshan, K. Gunst, J. Guo, C. Guo, L. Guo, M. Guo, W. Guo, X.-G. Gust, A.A. Gustafsson, Å.B. Gutierrez, E. Gutierrez, M.G. Gwak, H.-S. Haas, A. Haber, J.E. Hadano, S. 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Shintani, T. Shioi, T. Shirabe, K. Shiri-Sverdlov, R. Shirihai, O. Shore, G.C. Shu, C.-W. Shukla, D. Sibirny, A.A. Sica, V. Sigurdson, C.J. Sigurdsson, E.M. Sijwali, P.S. Sikorska, B. Silveira, W.A. Silvente-Poirot, S. Silverman, G.A. Simak, J. Simmet, T. Simon, A.K. Simon, H.-U. Simone, C. Simons, M. Simonsen, A. Singh, R. Singh, S.V. Singh, S.K. Sinha, D. Sinha, S. Sinicrope, F.A. Sirko, A. Sirohi, K. Sishi, B.J.N. Sittler, A. Siu, P.M. Sivridis, E. Skwarska, A. Slack, R. Slaninová, I. Slavov, N. Smaili, S.S. Smalley, K.S.M. Smith, D.R. Soenen, S.J. Soleimanpour, S.A. Solhaug, A. Somasundaram, K. Son, J.H. Sonawane, A. Song, C. Song, F. Song, H.K. Song, J.-X. Song, W. Soo, K.Y. Sood, A.K. Soong, T.W. Soontornniyomkij, V. Sorice, M. Sotgia, F. Soto-Pantoja, D.R. Sotthibundhu, A. Sousa, M.J. Spaink, H.P. Span, P.N. Spang, A. Sparks, J.D. Speck, P.G. Spector, S.A. Spies, C.D. Springer, W. Clair, D.S. Stacchiotti, A. Staels, B. Stang, M.T. Starczynowski, D.T. Starokadomskyy, P. Steegborn, C. Steele, J.W. Stefanis, L. Steffan, J. Stellrecht, C.M. Stenmark, H. Stepkowski, T.M. Stern, S.T. Stevens, C. Stockwell, B.R. Stoka, V. Storchova, Z. Stork, B. Stratoulias, V. Stravopodis, D.J. Strnad, P. Strohecker, A.M. Ström, A.-L. Stromhaug, P. Stulik, J. Su, Y.-X. Su, Z. Subauste, C.S. Subramaniam, S. Sue, C.M. Suh, S.W. Sui, X. Sukseree, S. Sulzer, D. Sun, F.-L. Sun, J. Sun, J. Sun, S.-Y. Sun, Y. Sun, Y. Sun, Y. Sundaramoorthy, V. Sung, J. Suzuki, H. Suzuki, K. Suzuki, N. Suzuki, T. Suzuki, Y.J. Swanson, M.S. Swanton, C. Swärd, K. Swarup, G. Sweeney, S.T. Sylvester, P.W. Szatmari, Z. Szegezdi, E. Szlosarek, P.W. Taegtmeyer, H. Tafani, M. Taillebourg, E. Tait, S.W.G. Takacs-Vellai, K. Takahashi, Y. Takáts, S. Takemura, G. Takigawa, N. Talbot, N.J. Tamagno, E. Tamburini, J. Tan, C.-P. Tan, L. Tan, M.L. Tan, M. Tan, Y.-J. Tanaka, K. Tanaka, M. Tang, D. Tang, D. Tang, G. Tanida, I. Tanji, K. Tannous, B.A. Tapia, J.A. Tasset-Cuevas, I. Tatar, M. Tavassoly, I. Tavernarakis, N. Taylor, A. Taylor, G.S. Taylor, G.A. Taylor, J.P. Taylor, M.J. Tchetina, E.V. Tee, A.R. Teixeira-Clerc, F. Telang, S. Tencomnao, T. Teng, B.-B. Teng, R.-J. Terro, F. Tettamanti, G. Theiss, A.L. Theron, A.E. Thomas, K.J. Thomé, M.P. Thomes, P.G. Thorburn, A. Thorner, J. Thum, T. Thumm, M. Thurston, T.L.M. Tian, L. Till, A. Ting, J.P.-Y. Ting, J.P.Y. Titorenko, V.I. Toker, L. Toldo, S. Tooze, S.A. Topisirovic, I. Torgersen, M.L. Torosantucci, L. Torriglia, A. Torrisi, M.R. Tournier, C. Towns, R. Trajkovic, V. Travassos, L.H. Triola, G. Tripathi, D.N. Trisciuoglio, D. Troncoso, R. Trougakos, I.P. Truttmann, A.C. Tsai, K.-J. Tschan, M.P. Tseng, Y.-H. Tsukuba, T. Tsung, A. Tsvetkov, A.S. Tu, S. Tuan, H.-Y. Tucci, M. Tumbarello, D.A. Turk, B. Turk, V. Turner, R.F.B. Tveita, A.A. Tyagi, S.C. Ubukata, M. Uchiyama, Y. Udelnow, A. Ueno, T. Umekawa, M. Umemiya-Shirafuji, R. Underwood, B.R. Ungermann, C. Ureshino, R.P. Ushioda, R. Uversky, V.N. Uzcátegui, N.L. Vaccari, T. Vaccaro, M.I. Váchová, L. Vakifahmetoglu-Norberg, H. Valdor, R. Valente, E.M. Vallette, F. Valverde, A.M. Van den Berghe, G. Van Den Bosch, L. van den Brink, G.R. van der Goot, F.G. van der Klei, I.J. van der Laan, L.J.W. van Doorn, W.G. van Egmond, M. van Golen, K.L. Van Kaer, L. Campagne, M.L. Vandenabeele, P. Vandenberghe, W. Vanhorebeek, I. Varela-Nieto, I. Vasconcelos, M.H. Vasko, R. Vavvas, D.G. Vega-Naredo, I. Velasco, G. Velentzas, A.D. Velentzas, P.D. Vellai, T. Vellenga, E. Vendelbo, M.H. Venkatachalam, K. Ventura, N. Ventura, S. Veras, P.S.T. Verdier, M. Vertessy, B.G. Viale, A. Vidal, M. Vieira, H.L.A. Vierstra, R.D. Vigneswaran, N. Vij, N. Vila, M. Villar, M. Villar, V.H. Villarroya, J. Vindis, C. Viola, G. Viscomi, M.T. Vitale, G. Vogl, D.T. Voitsekhovskaja, O.V. von Haefen, C. von Schwarzenberg, K. Voth, D.E. Vouret-Craviari, V. Vuori, K. Vyas, J.M. Waeber, C. Walker, C.L. Walker, M.J. Walter, J. Wan, L. Wan, X. Wang, B. Wang, C. Wang, C.-Y. Wang, C. Wang, C. Wang, C. Wang, D. Wang, F. Wang, F. Wang, G. Wang, H.-J. Wang, H. Wang, H.-G. Wang, H. Wang, H.-D. Wang, J. Wang, J. Wang, M. Wang, M.-Q. Wang, P.-Y. Wang, P. Wang, R.C. Wang, S. Wang, T.-F. Wang, X. Wang, X.-J. Wang, X.-W. Wang, X. Wang, X. Wang, Y. Wang, Y. Wang, Y. Wang, Y.-J. Wang, Y. Wang, Y. Wang, Y.T. Wang, Y. Wang, Z.-N. Wappner, P. Ward, C. Ward, D.M.V. Warnes, G. Watada, H. Watanabe, Y. Watase, K. Weaver, T.E. Weekes, C.D. Wei, J. Weide, T. Weihl, C.C. Weindl, G. Weis, S.N. Wen, L. Wen, X. Wen, Y. Westermann, B. Weyand, C.M. White, A.R. White, E. Whitton, J.L. Whitworth, A.J. Wiels, J. Wild, F. Wildenberg, M.E. Wileman, T. Wilkinson, D.S. Wilkinson, S. Willbold, D. Williams, C. Williams, K. Williamson, P.R. Winklhofer, K.F. Witkin, S.S. Wohlgemuth, S.E. Wollert, T. Wolvetang, E.J. Wong, E. Wong, G.W. Wong, R.W. Wong, V.K.W. Woodcock, E.A. Wright, K.L. Wu, C. Wu, D. Wu, G.S. Wu, J. Wu, J. Wu, M. Wu, M. Wu, S. Wu, W.K.K. Wu, Y. Wu, Z. Xavier, C.P.R. Xavier, R.J. Xia, G.-X. Xia, T. Xia, W. Xia, Y. Xiao, H. Xiao, J. Xiao, S. Xiao, W. Xie, C.-M. Xie, Z. Xie, Z. Xilouri, M. Xiong, Y. Xu, C. Xu, C. Xu, F. Xu, H. Xu, H. Xu, J. Xu, J. Xu, J. Xu, L. Xu, X. Xu, Y. Xu, Y. Xu, Z.-X. Xu, Z. Xue, Y. Yamada, T. Yamamoto, A. Yamanaka, K. Yamashina, S. Yamashiro, S. Yan, B. Yan, B. Yan, X. Yan, Z. Yanagi, Y. Yang, D.-S. Yang, J.-M. Yang, L. Yang, M. Yang, P.-M. Yang, P. Yang, Q. Yang, W. Yang, W.Y. Yang, X. Yang, Y. Yang, Y. Yang, Z. Yang, Z. Yao, M.-C. Yao, P.J. Yao, X. Yao, Z. Yao, Z. Yasui, L.S. Ye, M. Yedvobnick, B. Yeganeh, B. Yeh, E.S. Yeyati, P.L. Yi, F. Yi, L. Yin, X.-M. Yip, C.K. Yoo, Y.-M. Yoo, Y.H. Yoon, S.-Y. Yoshida, K.-I. Yoshimori, T. Young, K.H. Yu, H. Yu, J.J. Yu, J.-T. Yu, J. Yu, L. Yu, W.H. Yu, X.-F. Yu, Z. Yuan, J. Yuan, Z.-M. Yue, B.Y.J.T. Yue, J. Yue, Z. Zacks, D.N. Zacksenhaus, E. Zaffaroni, N. Zaglia, T. Zakeri, Z. Zecchini, V. Zeng, J. Zeng, M. Zeng, Q. Zervos, A.S. Zhang, D.D. Zhang, F. Zhang, G. Zhang, G.-C. Zhang, H. Zhang, H. Zhang, H. Zhang, J. Zhang, J. Zhang, J. Zhang, J.-P. Zhang, L. Zhang, L. Zhang, L. Zhang, M.-Y. Zhang, X. Zhang, X.D. Zhang, Y. Zhang, Y. Zhang, Y. Zhang, Y. Zhang, Y. Zhao, M. Zhao, W.-L. Zhao, X. Zhao, Y.G. Zhao, Y. Zhao, Y. Zhao, Y.-X. Zhao, Z. Zhao, Z.J. Zheng, D. Zheng, X.-L. Zheng, X. Zhivotovsky, B. Zhong, Q. Zhou, G.-Z. Zhou, G. Zhou, H. Zhou, S.-F. Zhou, X.-J. Zhu, H. Zhu, H. Zhu, W.-G. Zhu, W. Zhu, X.-F. Zhu, Y. Zhuang, S.-M. Zhuang, X. Ziparo, E. Zois, C.E. Zoladek, T. Zong, W.-X. Zorzano, A. Zughaier, S.M.
Published: 2016

21. Formaldehyde measurements in residential indoor air using a developed sensor element in the Kanto area of Japan

Author: Katsuyuki Izumi, T. Yamada, J. Nakamura, M. Uchiyama, and Y. Y. Maruo
Subjects: Environmental Engineering, Indoor air, Public Health, Environmental and Occupational Health, Environmental engineering, Formaldehyde, Air pollution, Building and Construction, medicine.disease_cause, β diketone, chemistry.chemical_compound, Linear relationship, chemistry, medicine, Practical implications, Air quality index, Exposure assessment
Abstract: UNLABELLED We undertook this to determine the formaldehyde concentration in Japanese houses and the relationship between formaldehyde levels and the age and temperature of a house using a sensor element that we developed for time-integrated measurements of formaldehyde concentration in actual environments. We evaluated the correlation between the formaldehyde concentration estimated by the dinitrophenylhydrazine (DNPH)-derivatization method and that obtained with our sensor element. We found a linear relationship between the two results indicating that reliable measurements can be performed using the developed sensor element in actual environments. The indoor concentration of formaldehyde was determined in a study of 34 homes in the Kanto area of Japan, between September 28 and October 27, 2007. We obtained the highest formaldehyde concentrations of 92 ± 15 μg/m(3) for apartments 0-2 years after their renovation, and a simple linear relationship was found between formaldehyde concentration and the age of the apartment. We also found that the formaldehyde concentration in a room containing furniture increased by 10% when the temperature increased by 1°C. PRACTICAL IMPLICATIONS This study contributed to the measurements of indoor formaldehyde levels. We have used a newly developed sensor for time-integrated measurements of formaldehyde concentrations. This sensor does not need a power supply during exposure to air, and does not need special skills to use. This research showed that homeowners successfully deployed the sensor at the desired place and desired period in their house by themselves. Formaldehyde is emitted by various off-gassing sources, such as furniture. Therefore, for example, homeowners may want to measure the change of formaldehyde levels in their house before and after installing new furniture. This sensor may also be deployed by occupants to reduce the cost of a large-scale exposure assessment study.
Published: 2010
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22. Regulatory T cells (PP-045)

Author: E. Tasaki, Y. Okuno, E. M. Bertram, H. Isaka, S. Delbauve, T. Nakashima, K. A. Newell, J. C. Antvorskov, H. Fan, S. Kawashima, G. Ying, D. Horwitz, T. Thomas, M. Feuerer, Akihiko Yoshimura, C. Elly, K. Wang, T. Kanzaki, K. Buschard, T. P. Arstila, T. Huenig, F. Mair, N. Perdue, J. Sprent, L. Lu, L. Akahira, Y. Yoshida, H. Feng, W. Wang, Howard L. Weiner, Thorsten Buch, T. Laurinolli, D. Lim, F. X. Qin, X. Cao, J. Bártová, Y. m. Cao, I. R. van Driel, S. Hong, C. Tsao, L. M. Kastner, E. M. Ross, J. Wang, T. Honda, S. Park, Y. Chung, S. Schwele, R. Haque, B. Li, T. Yoshikawa, Matthew C. Cook, B. H. Hahn, M. G. Netea, Aleksandar Bulog, I. Iwamoto, J. Liu, P. Fundova, M. Kibata, Y. Lee, C. C. Goodnow, F. Conti, J. S. LeMasurier, Jeffrey A. Bluestone, J. Kie, K. Soejima, N. Erfani, X. R. Zhou, R. J. Steptoe, I. Kim, M. A. Fernandez, C. S. Constantinescu, S. Bauchiero, X. Jin, D. S. Y. Tan, Holly A. Bolton, S. Hu, L. R. Wedderburn, V. Flamand, Z. Liu, K. Sugimura, S. Kunkel, J. M. Rolland, Takatoku Oida, T. Ho, Tobias Bopp, L. Zheng, Y. Li, S. Shen, K. Michishita, M. Shin, R. Germain, Y. Tang, S. Klein-Hessling, Q. h. Wang, X. P. Peng, S. Nakamura, Daniel J. Campbell, Irma Joosten, X. Jiang, M. Braitch, Z. Yao, Masahide Hamaguchi, V. Pancre, H. Lee, Y. Zheng, Y. Cui, W. Müller, R. White, H. Yue, Ai Harashima, J. Perheentupa, M. Tomura, A. T. Endharti, S. Gattenloehner, Kenji Kabashima, M. Goldman, Z. Sarraf, Mihoko Shibuya, T. Sasaki, Y. Kanno, M. Yamamoto, J. Lee, G. Y. Zhou, A. M. Fischer, Y. Kwon, Christophe Benoist, Z. Chen, M. Nakatsugawa, Y. Liu, Y. Park, K. Yamamoto, Dirk H. Busch, C. S. Constantinecsu, T. Hamamoto, A. Carpentier, Y. Zhou, Hans-Dieter Volk, Tomohisa Okamura, J. Tsukada, K. Webster, E. Rabellino, I. Debock, F. Lin, Vladimir Mićović, T. Wakayama, Josef Bodor, H. Bae, G. Metzner, A. Kwan, Ari Waisman, C. Pecli, C. Wu, J. Song, S. Imoto, S. Han, H. Tanizaki, M. Mariotti-Ferrandiz, J. Paik, S. M. Salonen, K. Kawahata, B. Adams, M. H. Nyirenda, C. L. Hardy, K. Isobe, L. M. Lu, J. R. Killebrew, O. Morales, D. P. Funda, A. R. Kendal, A. McNally, R. A. DePinho, Ryuji Iida, N. Sasaki, S. Kim, N. Yang, L. H. Rossi, G. Brestrich, L. Hsu, N. Wada, C. Lu, C. B. Schmidt-Weber, V. Seyfert-Margolis, A. J. van der ven, T. Nakatsura, V. Nikolaev, H. Collins, A. R. Kitching, Carla Jones, B. Yen, Z. J. Jiao, C. Chan, T. Nakagaki, M. Takeuchi, Hirofumi Shoda, G. Lee, G. Wang, T. V. Hogan, M. Plebanski, F. Stenard, F. Liu, A. Suto, T. Otani, K. Tsuji-Takayama, D. E. Furst, Y. Takasaki, Tim Sparwasser, A. Tanaka, M. Asakawa, J. H. Louie, D. Brand, D. W. Dwyer, S. Nakano, A. Okamoto, M. Imamura, L. Chi, C. Zhu, J. Zhu, P. Roubal, S. Dharancy, M. Dohi, E. Kekäläinen, S. I. Alexander, H. Kojima, Dong Han, Q. Wang, N. Delhem, K. Takahashi, D. M. Heery, J. Sun, N. Sakemura, B. Gran, T. Toraya, A. Feng, X. Shen, C. A. Garcia Santana, H. Itoh, S. Zheng, N. MacDonald, U. Behn, A. Facciabene, B. Chiang, W. Kastenmuller, M. W. Leung, Shuji Sumitomo, X. Qu, S. Huang, R. Molinaro, A. Kokešová, M. Bozza, S. Z. Josefowicz, K. Bourcier, D. Bourges, K. Hirose, S. Rahimifar, F. Yamasaki, K. Nistala, E. Serfling, E. Schmitt, Friederike Berberich-Siebelt, Y. Wang, G. Coukos, F. Gross, I. Drexler, L. Yang, T. Gogishvili, S. Kagami, Y. Harada, H. Nakajima, E. Market, Y. Chen, A. Sledzinska, Lin Tian, Amy L. Putnam, F. Cunha, Anthony E.J. Dubois, M. I. Greene, S. Kamei, J. J. Lafaille, D. Kolodin, P. A. Gleeson, Ranjeny Thomas, W. Bolton, Xiao-Sen Li, I. Osawa, C. Miroux, Y. Kang, J. Drbohlav, A. Chaudhry, C. F. Benjamim, C. Kang, A. Ghaderi, G. Zhang, R. P. Singh, M. Hong, S. R. Holdsworth, L. Sanvito, L. Wang, J. j. Wu, T. Kobata, M. Kuo, B. Kim, M. Michels, A. I. Kokaji, Z. Li, W. Shi, J. Yao, X. Xia, W. Chang, S. Choi, R. Nakagawa, Y. y. Pan, M. Vaeth, C. Canetti, F. Lei, P. Hsu, J. Alves-Filho, S. Hori, A. Šalaková, B. L. Wang, J. Wilkinson, P. Zdziarski, M. Fairhurst, Keishi Fujio, X. Zheng, H. Suzuki, R. K. Dinesh, Shimon Sakaguchi, Z. Jiang, S. Hemmers, B Fazekas de St Groth, M. Zelman-Femiak, H. Moncrieffe, L. Han, J. Park, M. Suzuki, S. Eaton, D. Sakurai, T. Inoue, F. Lhommé, S. Nishimoto, Ines Mrakovčić-Šutić, R. Mohamud, Matthias Klein, S. D'Costa, R. E. O'Hehir, N. Morishima, J. Cha, M. Schmueck, M. Uchiyama, K. Imi, H. Hase, E. Boleslowski, A. Liston, C. Park, P. Reinke, C. Shen, H. Wakashin, D. A. Horwitz, Ohkura Naganari, Herman Waldmann, A. Okochi, A. Khoo, I. Kubajewska, J. Seoh, A. Roemhild, Alexander Y. Rudensky, Diane Mathis, J. A. Altin, C. Liu, M. Lohse, T. Shimada, B. Yang, W. Liu, L. Turka, M. Kweon, G. Gasteiger, Hans J. P. M. Koenen, Y. Kim, S. Okuda, Burkhard Becher, and Osami Kanagawa
Subjects: Immunology, Immunology and Allergy, General Medicine
Published: 2010
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23. 120 × 90 element thermoelectric infrared focal plane array with precisely patterned Au-black absorber

Author: Y. Nakajima, M. Saito, M. Uchiyama, and M. Hirota
Subjects: Materials science, business.industry, Infrared, Detector, Metals and Alloys, Condensed Matter Physics, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Responsivity, Optics, Electrical resistance and conductance, Thermocouple, Thermoelectric effect, Absorptance, Optoelectronics, Electrical and Electronic Engineering, business, Instrumentation, Layer (electronics)
Abstract: This paper presents a 120 × 90 element thermoelectric infrared focal plane array with a precisely patterned Au-black absorber that provides high responsivity and a low cost potential. The device has a responsivity of 3900 V/W. The overall chip size is 14.4 mm × 11.0 mm with a 12.0 mm × 9.0 mm imaging area. Each detector consists of two pairs of p–n polysilicon thermocouples and has external dimensions of 100 μm × 100 μm and internal electrical resistance of 90 kΩ. The precisely patterned Au-black infrared absorbing layer was achieved by both a low-pressure vapor deposition technique and a lift-off technique utilizing a PSG sacrificial layer. These techniques make it possible to obtain a Au-black pattern with the same degree of accuracy as with the CMOS process. The Au-black layer showed high absorptance of more than 90% to the light source with a wavelength of from 8 to 13 μm. This performance is suitable for automotive applications as well as consumer electronics.
Published: 2007
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24. Association of serum low-density lipoprotein metabolism with oestrogen receptor gene polymorphisms in healthy children

Author: T Kikuchi, N Hashimoto, T Kawasaki, and M Uchiyama
Subjects: Pediatrics, Perinatology and Child Health, General Medicine
Published: 2007
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25. Successful case of adult ABO-incompatible liver transplantation: Beneficial effects of intrahepatic artery infusion therapy: A case report

Author: M Uchiyama, J Tashiro, T. Iwahori, Yuki Nakamura, K. Kuzuoka, Y. Kihara, Naoto Matsuno, K. Hama, Isao Akashi, Shinichiro Taira, Y. Jojima, Koichi Tanaka, Hitoshi Iwamoto, Osamu Konno, K Narumi, T. Yokoyama, Takeshi Nagao, and T. Sagara
Subjects: Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Splenectomy, Liver transplantation, ABO Blood-Group System, Hepatic Artery, Hepatolenticular Degeneration, Liver Function Tests, Infusion therapy, Living Donors, medicine, Humans, Infusions, Intra-Arterial, Disseminated intravascular coagulation, Transplantation, Intraoperative Care, medicine.diagnostic_test, business.industry, Plasmapheresis, Perioperative, medicine.disease, Liver Transplantation, Surgery, Treatment Outcome, Blood Group Incompatibility, Drug Therapy, Combination, business, Liver function tests, Immunosuppressive Agents
Abstract: Background: In Japan ABO-incompatible liver transplantation has been done on >100 occasions up to 2003. However
Published: 2004
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26. Practical design of flocculator for new polymeric inorganic coagulant - PSI

Author: Yasumoto Magara, M. Uchiyama, M. Saito, Tasuku Kamei, and Koichi Ohno
Subjects: Flocculation, Materials science, Alum, Sedimentation (water treatment), Mixing (process engineering), chemistry.chemical_element, Portable water purification, chemistry.chemical_compound, chemistry, Chemical engineering, Settling, Aluminium, Turbidity, Water Science and Technology
Abstract: Physical characteristics of flocs formed by new polymeric inorganic coagulant, polysilicato-iron coagulant (PSI) were investigated using kaolinite clay suspended water as test water. Floc density was determined by measuring floc settling velocity and spherical equivalent floc diameter. The floc density function proposed by Tambo and Watanabe could be applied to PSI. Flocs formed by PSI showed higher floc density than those formed by alum at the same floc size. Floc size distribution after the rapid mixing as also determined. PSI could produce well-grown flocs at the stirring speed of 300 rpm. Stirring at 300 rpm for 7 minutes, residual turbidity after 15 minute sedimentation became lower than rapid mixing at 120 rpm for 5 minutes followed by slow mixing at 40 rpm for 25 minutes. Flocs formed by PSI was much stronger than those formed by alum. Using the data obtained, the design parameters of flocculator by use of PSI were estimated following Tambo and WatanabeÕs procedure. According to the estimation, it was suggested that rapid mixing process alone can make well-grown flocs and slow mixing process, which is essential for the conventional water purification system using aluminium coagulants, can be eliminated by use of PSI.
Published: 2004
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27. 523 Development of an Electrochemical Machining Method for Machining Curved Holes

Author: T. Shibazaki and M. Uchiyama
Subjects: Materials science, Machining, Mold, medicine, Mechanical engineering, General Medicine, Composite material, Electrochemical machining, medicine.disease_cause
Published: 2003
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28. Brunsting-Perry type pemphigoid with IgG autoantibodies to laminin-332, BP230 and desmoplakins I/II

Author: Takahiro Hamada, Daisuke Tsuruta, T. Ishikawa, Shinichiro Yasumoto, Norito Ishii, M. Uchiyama, Takekuni Nakama, Teruki Dainichi, Tadashi Karashima, Bungo Ohyama, Yoshihiko Mitsuhashi, Shunpei Fukuda, Takashi Hashimoto, and Hiromi Kobayashi
Subjects: Pathology, medicine.medical_specialty, Pemphigoid, biology, business.industry, Desmoplakins, Autoantibody, Dermatology, medicine.disease, Laminin, Immunology, biology.protein, Medicine, business
Published: 2011
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29. Radiation-Induced Cavernous Malformations of the Cauda Equina Mimicking Carcinomatous or Infectious Meningitis. A Case Report

Author: Christopher M. Uchiyama, Phataraporn K. Thorson, Nikdokht Farid, Jack Zyroff, and Steven G. Imbesi
Subjects: musculoskeletal diseases, Pathology, medicine.medical_specialty, medicine.diagnostic_test, Nerve root, business.industry, Extended-Field Radiation Therapy, Cauda equina, Magnetic resonance imaging, Cavernous malformations, medicine.disease, medicine.anatomical_structure, Ectasia, Biopsy, Medicine, Radiology, Nuclear Medicine and imaging, Neurology (clinical), business, Testicular cancer
Abstract: The authors present a case of multiple radiation-induced cavernous malformations of the cauda equina in a patient with a remote history of testicular cancer and extended field radiation therapy. Magnetic resonance imaging (MRI) demonstrated multiple nodular areas of enhancement coating the nerve roots of the cauda equina, mimicking an aggressive leptomeningeal process such as carcinomatous or infectious meningitis. Biopsy of one of these lesions revealed ectatic vascular channels devoid of intervening neuroglial tissue consistent with cavernous malformation.
Published: 2011
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30. Receptor-mediated delivery of all trans-retinoic acid to hepatocyte using poly(l-lactic acid) nanoparticles coated with galactose-carrying polystyrene

Author: T. Sasagawa, M. Uchiyama, S. H. Kim, Toshihiro Akaike, Chong-Su Cho, In-Kyu Park, and K.Y Cho
Subjects: Male, Polymers, Polyesters, Retinoic acid, Pharmaceutical Science, Nanoparticle, Receptors, Cell Surface, Tretinoin, Asialoglycoprotein Receptor, Mice, chemistry.chemical_compound, Epidermal growth factor, Animals, Lactic Acid, Particle Size, Mice, Inbred ICR, DNA synthesis, Chemistry, Galactose, DNA, Receptor-mediated endocytosis, Lactic acid, Biochemistry, Hepatocytes, Biophysics, Polystyrenes, Asialoglycoprotein receptor, Drug carrier
Abstract: All trans-retinoic acid (RA)-loaded poly( l -lactic acid) (PLA) nanoparticles coated with galactose-carrying polymer, as hepatocyte-specific targeting material using galactose ligands as recognition signals to asialoglycoprotein receptors were prepared by the diafiltration method. Effects of released RA from its loaded nanoparticles on morphology and DNA synthesis of hepatocytes were studied. Receptor-mediated endocytosis of the nanoparticles was checked by fluorescence and confocal laser microscopy. It was found that the shapes of most hepatocytes attached onto polystyrene dish precoated with collagen solution were flat and spreading at low concentration of RA for the RA-loaded nanoparticles, whereas their shapes were round at even low concentration of RA when RA was mixed with the nanoparticles. From the fluorescence and confocal laser microscopic studies, it was suggested that the nanoparticles coated with galactose-carrying polymers were internalized by the hepatocytes through the receptor-mediated mechanism. The RA-loaded nanoparticles were more potent stimulators of hepatocyte DNA synthesis than the free RA system in the presence of epidermal growth factor (EGF) owing to the controlled release of RA from the RA-loaded nanoparticles.
Published: 2001
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31. sna41 goa1 , a novel mutation causing G1/S arrest in fission yeast, is defective in a CDC45 homolog and interacts genetically with pol α

Author: M. Uchiyama, Hisao Masai, and Ken-ichi Arai
Subjects: DNA Replication, Saccharomyces cerevisiae Proteins, Genotype, Genetic Linkage, Eukaryotic DNA replication, Biology, Origin of replication, S Phase, Fungal Proteins, Replication factor C, Minichromosome maintenance, Control of chromosome duplication, Schizosaccharomyces, Genetics, Hydroxyurea, DNA, Fungal, Molecular Biology, S phase, Cell Cycle, Genetic Complementation Test, G1 Phase, Temperature, DNA replication, Nuclear Proteins, General Medicine, DNA Polymerase I, DNA-Binding Proteins, Phenotype, Origin recognition complex, Schizosaccharomyces pombe Proteins, Carrier Proteins
Abstract: Proteins involved in the initiation of DNA replication play critical roles in the assembly and loading of replication complexes at replication origins. To gain further insight into the regulation of initiation, we screened in fission yeast for temperature-sensitive mutants which arrested at the G1/S boundary, and isolated nine mutants which arrested with a 1C DNA content at 36 degrees C. By linkage analysis, two complementation groups were identified which were not allelic to known G1 arrest mutations. One of the mutants isolated, sna41goul, arrested with a G1 DNA content and expressed a pleiomorphic phenotype, i.e., a mixture of cut and cdc phenotypes, at 36 degrees C. The point of arrest was identified as after START but before the hydroxyurea-induced block, by taking advantage of the mutant rad26.a14, which has a defect in an early S phase-specific checkpoint, and by performing reciprocal shift experiments. sna41 goal is allelic to sna41+, which is homologous to the CDC45 gene of budding yeast, and the mutation lies in a motif that is highly conserved in Cdc45-related proteins. The temperature sensitivity of the sna41goal mutant can be suppressed to some extent by ts mutations in polalpha. Our genetic results are consistent with a model in which Cdc45 plays crucial roles in the assembly of the replication apparatus at replication origins.
Published: 2001
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32. Purinergic Regulation of Intracellular Ca2+Concentration of Rat Pituitary Folliculo-Stellate Cells in Primary Culture

Author: M. Uchiyama, Yasuo Sakuma, Masakatsu Kato, and Y. Nakajima
Subjects: medicine.medical_specialty, Thapsigargin, Phospholipase C, Endocrine and Autonomic Systems, Ryanodine receptor, Endocrinology, Diabetes and Metabolism, Endoplasmic reticulum, Purinergic receptor, Inositol trisphosphate receptor, Biology, Cellular and Molecular Neuroscience, Paracrine signalling, chemistry.chemical_compound, Endocrinology, medicine.anatomical_structure, Anterior pituitary, chemistry, Internal medicine, medicine
Abstract: Pituitary folliculo-stellate cells (FSCs) are glia-like cells in the anterior pituitary and are believed to modulate the activity of the pituitary endocrine cells. However, little is known what regulates the activity of FSCs. We hypothesized that ATP could act on FSCs, because ATP is coreleased with pituitary hormones from endocrine cells. To test this possibility, we examined the effect of ATP by measuring intracellular Ca2+ concentration [Ca2+]i of FSCs in primary culture. Both ATP and UTP increased the [Ca2+]i in a concentration-dependent manner in a range between 0.1 microM and 10 microM. The response was completely suppressed by thapsigargin, an inhibitior of endoplasmic reticulum Ca2+-ATPase, and was significantly suppressed by U-73122, an inhibitor of phospholipase C. The response was also suppressed by caffeine, a blocker of IP3 receptor, whereas that was not suppressed by ryanodine, an antagonist of ryanodine receptor. These results indicate that ATP increases [Ca2+]i of FSCs by activating phospholipase C via P2Y purinergic receptor and suggest that ATP would be one of paracrine factors to FSCs in the anterior pituitary.
Published: 2001
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33. A Case of Retroperitoneal Mucinous Cystadenocarcinoma

Author: Takeshi Nagao, M Uchiyama, Takahiko Tsuji, and Naoto Matsuno
Subjects: medicine.medical_specialty, business.industry, Medicine, Radiology, Mucinous cystadenocarcinoma, business, medicine.disease
Abstract: 後腹膜原発の嚢胞腺癌は極めて稀な症患である.今回われわれは後腹膜原発性粘液性嚢胞腺癌を経験したので報告し,同時に本邦報告例23例について文献的考察を加えた.症例は39歳女性,主訴は腹痛.左側腹部に無痛性の腫瘤が触知され,腹部CT, 腹部超音波検査にて大きさ20cm×18cm×15cmの嚢胞腫瘤とその内腔へ突出した直径2.0cm大の乳頭状嚢胞内腫瘤を認めた.腹部血管造影で左下腹部の血管に圧排所見を認めた.注腸にては圧排所見のみで異常所見を認めなかった.開腹所見では下行結腸の後外側方に位置した巨大腫瘤が結腸を壁外性に圧迫していた.摘出した後腹膜腫瘍は嚢胞性腫瘤で内腔に突出する乳頭状腫瘤を認め病理組織学的には粘液性嚢胞腺癌と診断された.嚢胞液中および免疫組織学的検討で嚢胞壁のCA 19-9が陽性であった.術後約2年の現在,再発の兆しもなく生存中である.他臓器の異常所見もなく後腹膜原発の腫瘤と考えられた.
Published: 2001
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34. Melatonin Rhythms in Delayed Sleep Phase Syndrome

Author: K. Shibui, M. Uchiyama, and M. Okawa
Subjects: Physiology, Physiology (medical)
Published: 1999
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35. Evolução dos níveis de beta-hCG após tratamento sistêmico da gravidez ectópica íntegra Evolution of beta-hCG titers after treatment with methotrexate in unruptured ectopic pregnancy

Author: J. Elito Junior, M. Uchiyama, and L. Camano
Subjects: lcsh:R5-920, Methotrexate, Ectopic pregnancy, Gravidez ectópica, Beta-hCG, lcsh:Medicine (General), Metotrexato
Abstract: OBJETIVO: O tratamento sistêmico da gravidez ectópica (GE) íntegra com metotrexato (MTX) tornou-se conduta alternativa para tradicional atitude cirúrgica. O acompanhamento dos casos é realizado com dosagens seriadas de beta-hCG, já que a imagem ultra-sonográfica persiste por tempo prolongado, sendo um parâmetro ruim de seguimento. O objetivo do nosso estudo é de avaliar o comportamento da curva de beta-hCG após a ministração do medicamento. PACIENTES E MÉTODO: Foram incluídas neste estudo pacientes estáveis hemodinamicamente, com massa anexial menor ou igual a 4,5cm, sem sinais de doença hepática, renal ou supressão da medula óssea. O tratamento foi feito com MTX 50mg/m² IM (dose única) em regime de internação. Vinte e quatro pacientes fizeram parte deste trabalho e foram acompanhadas com dosagens de beta-hCG nos dias 1, 4 e 7 pós-MTX. Casos em que os títulos de beta-hCG caíram acima de 15% entre os dias 4 e 7 receberam alta hospitalar e eram acompanhados semanalmente até títulos negativos. Por outro lado, quando esta queda era inferior a 15%, essas pacientes receberam nova dose de MTX. RESULTADOS: Doze (50,0%) dos 24 casos tiveram aumento dos títulos de beta-hCG nos primeiros quatro dias após a injecão IM de MTX, oito (33,3%) apresentaram queda paulatina dos valores e em quatro (16,7%) casos os valores de beta-hCG foram negativos no quarto dia pós-MTX. Apenas duas pacientes (8,3%) necessitaram de segunda dose de MTX por não ter havido queda dos títulos de beta-hCG superior a 15% entre o quarto e o sétimo dia. CONCLUSÕES: A elevação dos títulos de beta-hCG, entre o momento da ministração do MTX e o quarto dia após a medicação, foi evento freqüente (50,0%). A queda de mais de 15% dos valores de beta-hCG, apurada no quarto e no sétimo dia pós-MTX, constitui parâmetro importante para o critério de alta hospitalar. Por outro lado, redução menor que 15% dos níveis séricos de beta-hCG representa indicação para ministração de nova dose de MTX. Em apenas duas pacientes (8,4%) houve necessidade de segunda dose de MTX, pois os títulos de beta-hCG, avaliados no quarto e no sétimo dia após o MTX, apresentaram queda, porém, inferior a 15%.OBJECTIVE: The follow-up of this treatment is done by monitorization of beta-hCG titers. The objective of this study is to evaluate the beta-hCG titers after treatment with MTX. METHODS:. Twenty four women were included in the study. The inclusion criteria were: ectopic pregnancy < 4.5cm, beta-hCG < 15.000mIU/mL, desire of future pregnancy and a written permission to participate in the study. All patients were treated with a single dose of methotrexate (50mg/m² IM). Patients were monitored with beta-hCG titers on days 1, 4 and 7 after the MTX injection, and then weekly until the beta-hCG was less than 25mIU/mL. RESULTS: The variation of the titers of beta-hCG between day 1 and day 4 after MTX was the following: increase 50,0%, decrease 33.3% and in levels less than 25mUI/mL in 16.7% of the cases. The variation of the titers of beta-hCG between day 4 and day 7 after MTX was the following: decline > 15% in 85.7% of the cases, and decline < 15% in 14.3%. There was the necessity of a second dose of MTX in only two cases (8.4%), since the levels of beta-hCG declined less than 15%, in this period. CONCLUSION: The titers of beta-hCG increase in 50.0% of the cases, so it is a frequent event. The understanding of this evolution of beta-hCG titers avoids surgery in the first week of the treatment.
Published: 1998

36. Lymphocyte Sensitivity to Cyclosporine and Tacrolimus in Chronic Renal Failure Patients and Clinical Significance in Renal Transplantation

Author: K Mizumoto, Naoto Matsuno, E Sakurai, Takao Akashi, T Degawa, Toshihiko Hirano, M Uchiyama, K Kozaki, Hironori Takeuchi, Masami Kozaki, Kitaro Oka, and Takeshi Nagao
Subjects: Adult, Male, medicine.medical_specialty, Lymphocyte, Drug Resistance, Urology, Tacrolimus, Humans, Medicine, Clinical significance, Lymphocytes, Transplantation, Kidney, business.industry, Middle Aged, Ciclosporin, Kidney Transplantation, Predictive factor, Treatment Outcome, medicine.anatomical_structure, Immunology, Cyclosporine, Kidney Failure, Chronic, Chronic renal failure, Female, Surgery, business, Immunosuppressive Agents, medicine.drug
Published: 1998
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37. Electrochemical Removal of Allylic Protecting Groups in Nucleotide Synthesis

Author: Ryoji Noyori, Yoshio Hayakawa, M. Uchiyama, Shigeharu Wakabayashi, and Rie Kawai
Subjects: chemistry.chemical_classification, Allylic rearrangement, chemistry.chemical_element, General Medicine, Nucleotide synthesis, Electrochemistry, Biochemistry, Combinatorial chemistry, chemistry, Genetics, Nucleic acid, Molecular Medicine, Nucleotide, Palladium
Abstract: Electrochemical, palladium(0)-mediated removal of allylic protecting groups of nucleosides and nucleotides is described. This method required no chromatographic treatment for isolation of the products. This paper is dedicated to the late Dr. Tsujiaki Hata in recognition of his outstanding contribution to nucleic acid science.
Published: 1998
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38. Vibration suppression control of 3D flexible robots using velocity inputs

Author: M. Uchiyama, Atsushi Konno, and S. López-Linares
Subjects: Scheme (programming language), Engineering, business.industry, Control engineering, Term (time), Computer Science::Robotics, Vibration, Planar, Quadratic equation, Control and Systems Engineering, Position (vector), Control theory, Robot, business, computer, Servo, computer.programming_language
Abstract: Research on vibration suppression control of flexible robots has concentrated mainly on the one-link and two-link planar manipulators. Most of the techniques that have been presented cannot be easily extended to the case of a general 3D flexible robot. In this article we present a general control scheme based on hardware velocity servo cards. The velocity commands to move the robot are calculated by adding a vibration suppression term to the joint position feedback employed in “rigid” robots. Two different methods are proposed to calculate this term, one based on optimum quadratic control and the other based on pseudo-inverse nonlinear decoupling. These techniques are studied numerically in the case of a real two-link three-joint flexible robot, by computing the values of the closed-loop poles at different configurations. Experiments on position stabilization of the robot prove the validity of our methods.© 1997 John Wiley & Sons, Inc.
Published: 1997
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39. Spatial Flexible Manipulator Trajectory Control Through Solving the Inverse Kinematics

Author: Y.Q. Dai, A.A. Loukianov, and M. Uchiyama
Subjects: Computer Science::Robotics, Computer simulation, Inverse kinematics, Computer science, Position (vector), Control theory, Numerical analysis, Iterative learning control, Manipulator, Revolute joint
Abstract: In this paper, the inverse kinematics of a spatial flexible link manipulator which is the most fundamental issue in Cartesian space trajectory control, is investigated. First, based on some rational assumptions, an approximate solution in the sense that the problem is solved not fully dynamically, is found by a numerical method. Next, a numerical iterative learning approach is presented to further reduce the end-effector's position errors remained in the approximate solution. Convergence analysis for both methods are also conducted. Numerical simulation and real experiment are carried out on a laboratory manipulator with two flexible links and three rigid revolute type joints. Results are shown to validate the proposed methods.
Published: 1997
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40. Configuration- Dependent Vibration Controllability of Flexible-Link Manipulators

Author: Atsushi Konno, Yutaka Kito, M. Uchiyama, and Mahito Murakami
Subjects: 0209 industrial biotechnology, Engineering, business.industry, Applied Mathematics, Mechanical Engineering, Mode (statistics), 02 engineering and technology, Workspace, Vibration, Controllability, 020901 industrial engineering & automation, Modal, Artificial Intelligence, Control theory, Normal mode, Modeling and Simulation, 0202 electrical engineering, electronic engineering, information engineering, 020201 artificial intelligence & image processing, Electrical and Electronic Engineering, business, Link (knot theory), Actuator, Software
Abstract: In this article, the structural vibration controllability of flexible- link manipulators is discussed. For some spatial flexible- link manipulators, the structural vibration controllability is configuration-dependent. Therefore, the flexible-link manipulator may have some vibration-uncontrollable configurations. To un derstand the physical interpretation of vibration-uncontrollable configurations, we propose the modal accessibility concept, which indicates how well the actuators can affect the structural vibration modes. The configuration in which all of the actua tors cannot affect at least one of the manipulator's vibration modes is vibration uncontrollable. Main contributions of this article are the following two points: first, interesting structural vibration-uncontrollable configurations are found within the two-link, three-joint-type manipulator's workspace, and are verified experimentally; second, the modal accessibility index is introduced to indicate how well the corresponding vibration mode is controllable. Experimental results show that even in the controllable configurations, it becomes difficult to suppress vibration if the modal accessibility is small.
Published: 1997
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41. Requirement of IL-4 and liver NK1+ T cells for concanavalin A-induced hepatic injury in mice

Author: S Toyabe, S Seki, T Iiai, K Takeda, K Shirai, H Watanabe, H Hiraide, M Uchiyama, and T Abo
Subjects: Immunology, Immunology and Allergy
Abstract: Con A-induced hepatic injury of mice accompanied by elevated transaminase was inhibited after in vivo depletion of liver NK cells and NK1+ T cells with intermediate TCR by anti-NK1 Ab or anti-IL-2Rbeta Ab. However, depletion of liver NK cells alone by anti-asialo-GM1 Ab did not inhibit hepatic injury. Although depletion of NK1+ T cells inhibited Con A-induced IL-2R expression of CD4+ high TCR (TCRhigh) cells and IL-4 mRNA expression of hepatic mononuclear cells, exogenous IL-4 engendered Con A-induced hepatic injury and endowed the expression of IL-2R of CD4+ TCRhigh cells. It was also found that in vivo treatment with anti-IL-4 Ab before Con A administration inhibited Con A-induced hepatic injury. In addition, although Con A did not induce hepatic injury in MHC class I-deficient mice, exogenous IL-4 again engendered severe hepatic injury in these mice. Further, while serum TNF-alpha levels induced by Con A were greatly decreased in NK1+ T cell-depleted mice and class I-deficient mice, TNF-alpha levels were recovered by exogenous IL-4. These findings reveal that although CD4+ TCRhigh cells in the liver and their production of TNF-alpha are the direct effectors of Con A-induced hepatic injury, liver NK1+ T cells also play an important role in this hepatitis model. Con A hepatitis may serve as an experimental model for human autoimmune hepatitis.
Published: 1997
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42. Estimation of the Counting Efficiences for Individual Subjects in 137Cs Whole Body Counting, Using Voxel Phantoms

Author: T. Ishikawa and M. Uchiyama
Subjects: Whole body counting, Radiation, Radiological and Ultrasound Technology, Adult male, Body height, business.industry, Monte Carlo method, Counting efficiency, Public Health, Environmental and Occupational Health, General Medicine, Body size, computer.software_genre, Imaging phantom, Voxel, Radiology, Nuclear Medicine and imaging, Nuclear medicine, business, computer, Mathematics
Abstract: A method is described to estimate the counting efficiency appropriate to the body size of each individual subject in 137 Cs whole-body counting, using voxel phantoms. Individual voxel phantoms approximate to the body sizes of subjects were prepared by expanding and contracting the standard voxel phantom that corresponds to a Japanese standard adult male. The individual phantom was made to have the same body height and weight as those of each individual subject. For a whole-body counter at NIRS (Japan), the counting efficiencies for ten subjects were calculated, using the voxel phantoms and a Monte Carlo simulation code. The differences in the counting efficiency between each individual phantom and a conventional phantom ranged from -5 to +12%. The counting efficiency is larger in small body sizes than in large body sizes. The results indicate that body burdens tended to be overestimated in subjects of small body sizes.
Published: 1997
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43. Vibration Controllability of 3D Flexible Manipulators

Author: S. López-Linares, Atsushi Konno, and M. Uchiyama
Subjects: Engineering, business.industry, Mechanical Engineering, Vibration control, Control engineering, Robotics, Workspace, Computer Science Applications, Computer Science::Robotics, Vibration, Controllability, Singular value, Control and Systems Engineering, Control theory, Robot, Artificial intelligence, business, Actuator, Instrumentation, Information Systems
Abstract: Structural vibrations of flexible robots are not always fully controllable in all the workspace. In some cases, there exist configurations where the actuators cannot affect some of the vibration modes, and thus cannot control their vibrations. This problem has been neglected in the case of the one-link and two-link planar manipulators; however, it must be dealt with in depth when trying to control a 3D flexible robot. This paper discusses the vibration controllability of flexible manipulators. Vibration uncontrollable configurations are estimated both by the minimum singular values of the controllability matrix and the closed-loop behavior. A 2-link 3-joint prototype flexible manipulator is used for a case study, and the uncontrollable configurations of the manipulator are found.
Published: 1997
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44. Crucial role of CD8-positive lymphocytes in glomerular expression of ICAM-1 and cytokines in crescentic glomerulonephritis of WKY rats

Author: H Fujinaka, T Yamamoto, L Feng, K Kawasaki, E Yaoita, S Hirose, S Goto, C B Wilson, M Uchiyama, and I Kihara
Subjects: Immunology, Immunology and Allergy
Abstract: CD8-positive lymphocytes (CD8+ lym) and ICAM-1/LFA-1 interaction have been implicated in the glomerular accumulation of monocytes/macrophages (Mo/Mphi) and crescent formation in antiglomerular basement membrane (anti-GBM) glomerulonephritis of WKY rats. In the present study, the role of CD8+ lym in the expression of ICAM-1 and inflammatory cytokines as well as in the accumulation of Mo/Mphi in the glomeruli was examined by RNase protection assay and immunofluorescence microscopy. ICAM-1 expression was apparent at 1 h and markedly enhanced at day 3 in glomeruli after an anti-GBM Ab injection in parallel with glomerular accumulation of Mo/Mphi. Expression of mRNA for IL-1beta, TNF-alpha, and IFN-gamma, known to enhance ICAM-1 expression, and MIP-1alpha, MIP-1beta, and MCP-1, known to activate leukocyte integrins or to act as chemokines, were also induced in the glomeruli at a mRNA level in a profile similar to that of ICAM-1 expression. By depleting the CD8+ lym in the circulation, the increased glomerular expression of ICAM-1 and the cytokines, except IL-1beta, and the Mo/Mphi accumulation were suppressed, indicating a crucial role of CD8+ lym in the accumulation of Mo/Mphi through stimulation of ICAM-1 and induction of cytokines.
Published: 1997
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45. Vibration suppression control of constrained spatial flexible manipulators

Author: Koki Suzuki, Jin-Soo Kim, Mitsuhiro Yamano, and M. Uchiyama
Subjects: Vibration, Mechanism (engineering), Engineering, Planar, Dependency (UML), business.industry, Position (vector), Distributed parameter system, Control theory, Vibration control, Control engineering, business, Contact force
Abstract: 科研費報告書収録論文(課題番号:07455416・基盤研究(B)(2)・H7～H9/研究代表者:内山, 勝/フレキシブル双腕ロボットの協調制御に関する研究), Proceedings : 1997 IEEE International Conference on Robotics and Automation : April 20-25, 1997 Albuquerque, New Mexico
Published: 1997

46. Calculation of Counting Efficiency for 137Cs Using Voxel Phantoms with Lungs and a Skeleton

Author: T. Ishikawa and M. Uchiyama
Subjects: Radiation, Materials science, Radiological and Ultrasound Technology, business.industry, Monte Carlo method, Counting efficiency, Public Health, Environmental and Occupational Health, General Medicine, computer.software_genre, Skeleton (computer programming), Imaging phantom, Voxel, Calibration, Radiology, Nuclear Medicine and imaging, Nuclear medicine, business, computer, Biomedical engineering
Abstract: Calibration of whole-body counters for 137 Cs is generally conducted with physical phantoms which are uniformly filled with 137 Cs solutions. To check the conventional calibration, two types of mathematical voxel phantoms were prepared; the phantom with uniform density and that with lungs and a skeleton. Five different sizes, from newborn to adult were prepared for each type of the voxel phantoms. As for a whole-body counter at NIRS (Japan), counting efficiencies for these voxel phantoms were calculated using a Monte Carlo simulation code. The counting efficiency for the phantom with the lungs and skeleton was larger than that for the uniform density phantom for each size. The difference of counting efficiency ranged from 3 to 5% for five sizes. For the adult, it was about 5%. This indicates that the conventional calibration phantoms, assuming uniform activity distribution and uniform density, were acceptable for 137 Cs whole-body counting.
Published: 1997
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47. A hybrid numerical method for solving the inverse kinematics of a class of spatial flexible manipulators

Author: A.A. Loukianov, M. Uchiyama, and Y.Q. Dai
Subjects: Inverse kinematics, Iterative method, Control theory, Numerical analysis, Iterative learning control, Convergence (routing), Stability (learning theory), Inverse problem, Numerical stability, Mathematics
Abstract: 科研費報告書収録論文(課題番号:07455416・基盤研究(B)(2)・H7～H9/研究代表者:内山, 勝/フレキシブル双腕ロボットの協調制御に関する研究), Proceedings : 1997 IEEE International Conference on Robotics and Automation : April 20-25, 1997 Albuquerque, New Mexico
Published: 1997

48. Choroid Plexus Papilloma and Cysts in the Aicardi Syndrome: Case Reports

Author: Carolyn M. Carey, Lynn D. Falkner, Richard S. Boyer, Christopher M. Uchiyama, Marion L. Walker, Douglas L. Brockmeyer, and W. Bruce Cherny
Subjects: Male, Choroid Plexus Neoplasms, Pathology, medicine.medical_specialty, Eye disease, Retina, Aicardi syndrome, otorhinolaryngologic diseases, medicine, Humans, Choroid plexus cyst, Brain Diseases, Choroid, Cysts, business.industry, Infant, Glioma, Syndrome, General Medicine, Anatomy, Chorioretinal lacunae, medicine.disease, Magnetic Resonance Imaging, Choroid plexus papilloma, eye diseases, medicine.anatomical_structure, Pediatrics, Perinatology and Child Health, Papilloma, Female, Surgery, Choroid plexus, sense organs, Neurology (clinical), Agenesis of Corpus Callosum, business, Spasms, Infantile, Optic disc
Abstract: Two female infants with callosal agenesis, infantile spasms, chorioretinal lacunae, optic disc colobomas and cortical heterotopias were diagnosed with Aicardi syndrome. A choroid plexus papilloma was found in one patient, and choroid plexus cysts were found in the other. Choroid plexus lesions are common findings in the Aicardi syndrome and are discussed in this paper.
Published: 1997
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49. Optimal Dose and Target Trough Level in Cyclosporine and Tacrolimus Conversion in Renal Transplantation as Evaluated by Lymphocyte Drug Sensitivity and Pharmacokinetic Parameters

Author: Hitoshi Iwamoto, Yuki Nakamura, Kiyoshi Okuyama, Isao Akashi, M Uchiyama, Osamu Konno, K. Hama, Tatsuto Ashizawa, Naoto Matsuno, Hironori Takeuchi, T. Iwahori, Takeshi Nagao, Kitaro Oka, Toshihiko Hirano, and Y. Jojima
Subjects: Transplantation, business.industry, chemical and pharmacologic phenomena, Pharmacology, Ciclosporin, Kidney Transplantation, Tacrolimus, Calcineurin, stomatognathic diseases, stomatognathic system, Pharmacokinetics, Area Under Curve, Pharmacodynamics, Cyclosporine, medicine, Humans, Potency, Trough level, Surgery, Lymphocytes, business, Immunosuppressive Agents, Antibacterial agent, medicine.drug
Abstract: We evaluated the relative clinical potency of cyclosporine (CyA) and tacrolimus (Tac) using pharmacodynamic and pharmacokinetic parameters of the drug to obtain the most suitable converting dose and target trough level. The relative pharmacodynamic potency was examined by the mean ratio of drug concentrations giving 50% inhibition of blastogenesis of lymphocytes (IC50) in 66 chronic renal failure patients. The relative potency estimated from clinical pharmacokinetic parameters was examined by the mean ratio of each pharmacokinetic parameter value of CyA versus Tac. The pharmacokinetic parameters were estimated by 12-hour monitoring of drug blood concentrations in seven CyA patients and seven Tac patients. The mean IC50 ratio of CyA and Tac (CyA/Tac of IC50) was 25.1. The mean area under the concentration-time curve (AUC) ratio (CyA/Tac of AUC) was 25.5, the mean trough level (C(min)) ratio (CyA/Tac of C(min)) was 13.2, and the mean dose per body weight ratio was 25.2. The relative potency estimated from AUC that is the most reliable pharmacokinetic parameter for the estimation of clinical efficacy of calcineurin inhibitors appeared to agree with the relative pharmacodynamic potency estimated from IC50. The data suggest that TAC 25-fold more potent than CyA, which represents a suitable converting dose ratio, and that target trough level of CyA is about 13-fold greater than Tac based on CyA/Tac of C(min). We conclude that these relative values may be useful to estimate the suitable dose and target trough levels to convert between CyA and Tac.
Published: 2005
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50. Radial flow bioreactor for the creation of bioartificial liver and kidney

Author: Yuki Nakamura, Isao Akashi, Tatsuto Ashizawa, Takeshi Nagao, Y. Johjima, Naoto Matsuno, M Uchiyama, Hitoshi Iwamoto, Osamu Konno, K. Hama, and T. Iwahori
Subjects: Carcinoma, Hepatocellular, Cell Culture Techniques, Biology, Kidney, Cell Line, law.invention, Perfusion Culture, law, medicine, Bioreactor, Animals, Humans, Transplantation, urogenital system, Liver Neoplasms, Bioartificial liver device, Microcarrier, Equipment Design, medicine.disease, Liver, Artificial, digestive system diseases, Cell biology, medicine.anatomical_structure, Cell culture, Hepatocellular carcinoma, Urea cycle, Immunology, lipids (amino acids, peptides, and proteins), Surgery, Kidneys, Artificial
Abstract: A radial flow bioreactor (RFB) is used for a three-dimensional perfusion culture of hepatocellular carcinoma (HCC) cells and renal cells, to create a bioartificial liver and kidney. The cylindrical reactor is filled with porous cellulose microcarrier. RFB can be characterized as a system in which the medium flows from the periphery toward the center of the reactor, thereby delivering an adequate supply of oxygen and nutrients to cells at the center as well as at the periphery. HCC cells incubated in the RFB system at high density maintained viability for long periods of time. Proximal tubular cells (LLC-PK1) as well as HCC cells, but not human immortalized mesangial cells (HMC) were cultured in the RFB for more than 14 days. The mRNA expression of some enzymes involved in the urea cycle, cytochrome P450s in HCC cells, and the 1-alpha-hydroxylase (CYP27B1) in LLC-PK1 cells was higher than that in monolayer cultures. These results suggest that the RFB system composed of HCC cells or renal cells may be useful for a bioartificial liver and kidney.
Published: 2005
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