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3. Efficient markerless integration of genes in the chromosome of probiotic E. coli Nissle 1917 by bacterial conjugation

Author

Elena M. Seco and Luis Ángel Fernández

Subjects
Biotechnology, TP248.13-248.65
Abstract

Summary The probiotic strain Escherichia coli Nissle 1917 (EcN) is a common bacterial chassis in synthetic biology developments for therapeutic applications given its long track record of safe administration in humans. Chromosomal integration of the genes of interest (GOIs) in the engineered bacterium offers significant advantages in genetic stability and to control gene dose, but common methodologies relying on the transformation of EcN are inefficient. In this work, we implement in EcN the use of bacterial conjugation in combination with markerless genome engineering to efficiently insert multiple GOIs at different loci of EcN chromosome, leaving no antibiotic resistance genes, vector sequences or scars in the modified bacterium. The resolution of cointegrants that leads to markerless insertion of the GOIs requires expression of I‐SceI endonuclease and its efficiency is enhanced by λ Red proteins. We show the potential of this strategy by integrating different genes encoding fluorescent and bioluminescent reporters (i.e. GFP, mKate2, luxCDABE) both individually and sequentially. We also demonstrate its application for gene deletions in EcN (ΔflhDC) and to replace the endogenous regulation of chromosomal locus (i.e. flhDC) by heterologous regulatory elements (e.g. tetR‐Ptet) in order to have an ectopic control of gene expression in EcN with an external inducer to alter bacterial behaviour (e.g. flagellar motility). Whole‐genome sequencing confirmed the introduction of the designed modifications without off‐target alterations in the genome. This straightforward approach accelerates the generation of multiple modifications in EcN chromosome for the generation of living bacterial therapeutics.

Published
2022
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4. Real-Time Incident-Responsive Signal Control Strategy under Partially Connected Vehicle Environment

Author

Kancharla K. K. Chandan, Álvaro J. M. Seco, and Ana M. C. Bastos Silva

Subjects
Transportation engineering, TA1001-1280, Transportation and communications, HE1-9990
Abstract

The performance of the traffic system can drastically drop when nonrecurrent congestion caused by incidents occurs. Early detection and clearing of traffic incidents will enable the mitigation of the congestion and early restoration of normal traffic conditions. The research in this paper utilized the vehicle information from the recent technological advancement in transportation systems, connected vehicles (CV), and loop-detector information for nonconnected vehicles (NCVs) and developed a novel algorithm to (1) control traffic signals for normal traffic conditions in the absence of incidents, (2) detect traffic incidents using CV/NCV information, and (3) control traffic signals during the occurrence and dissipation of incidents. All the 3 strategies were integrated into one algorithm, which runs as per the real-time traffic conditions, in the presence or absence of incidents. Space-mean speeds of the vehicles on nonincident lanes and throughput maximization criteria were taken as the indicators for the activation of specific signal timings directed at the incident-affected approach. Diverse incident scenarios were tested on a four-legged isolated intersection using the VISSIM simulation tool. Incident detection results showed a higher detection rate and lower mean detection time at higher CV penetration and higher traffic volumes, and at the incident locations nearer to the stop-line. The proposed incident-responsive signal control strategy at 40% and higher CV penetration showed better performance over EPICS adaptive signal control solution, in reducing average travel time delay and the average number of stops per vehicle.

Published
2022
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5. Slow Magnetic Relaxation and Modulated Photoluminescent Emission of Coordination Polymer Based on 3-Amino-4-hydroxybenzoate Zn and Co Metal Ions

Author

Estitxu Echenique-Errandonea, Sara Rojas, Javier Cepeda, Duane Choquesillo-Lazarte, Antonio Rodríguez-Diéguez, and José M. Seco

Subjects
metal-organic framework, cobalt-zinc bifunctionality, induced molecular magnetism, photoluminescent properties, Organic chemistry, QD241-441
Abstract

As a starting point, a new 3D porous framework with the {[CoL]·0.5DMF·H2O}n chemical formula (where L = 3-amino-4-hydroxybenzoate) is described. Its performance as a single molecule magnet was explored. The study of magnetic properties reveals that Co-MOF shows no frequency-fdependant alternating current (ac) signals under zero direct current (dc) magnetic field, whereas single-molecule magnet behaviour is achieved when CoII ions are diluted in a ZnII based matrix. Interestingly, this strategy renders a bifunctional [CoxZn1-xL]n material that is also characterized by a strong photoluminescent emitting capacity.

Published
2023
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6. Wilm’s tumor 1 promotes memory flexibility

Author

Chiara Mariottini, Leonardo Munari, Ellen Gunzel, Joseph M. Seco, Nikos Tzavaras, Jens Hansen, Sarah A. Stern, Virginia Gao, Hossein Aleyasin, Ali Sharma, Evren U. Azeloglu, Georgia E. Hodes, Scott J. Russo, Vicki Huff, Marc R. Birtwistle, Robert D. Blitzer, Cristina M. Alberini, and Ravi Iyengar

Subjects
Science
Abstract

Impairments in memory flexibility are associated with neuropsychiatric disorders such as PTSD and autism. Here, the authors report that the transcriptional repressor Wilm's Tumor 1 regulates synaptic plasticity leading to weakening of memory strength and enabling memory flexibility.

Published
2019
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7. Circulating miR-323-3p is a biomarker for cardiomyopathy and an indicator of phenotypic variability in Friedreich’s ataxia patients

Author

M. Seco-Cervera, D. González-Rodríguez, J. S. Ibáñez-Cabellos, L. Peiró-Chova, P. González-Cabo, E. García-López, J. J. Vílchez, I. Sanz-Gallego, F. V. Pallardó, and J. L. García-Giménez

Subjects
Medicine, Science
Abstract

Abstract MicroRNAs (miRNAs) are noncoding RNAs that contribute to gene expression modulation by regulating important cellular pathways. In this study, we used small RNA sequencing to identify a series of circulating miRNAs in blood samples taken from Friedreich’s ataxia patients. We were thus able to develop a miRNA biomarker signature to differentiate Friedreich’s ataxia (FRDA) patients from healthy people. Most research on FDRA has focused on understanding the role of frataxin in the mitochondria, and a whole molecular view of pathological pathways underlying FRDA therefore remains to be elucidated. We found seven differentially expressed miRNAs, and we propose that these miRNAs represent key mechanisms in the modulation of several signalling pathways that regulate the physiopathology of FRDA. If this is the case, miRNAs can be used to characterize phenotypic variation in FRDA and stratify patients’ risk of cardiomyopathy. In this study, we identify miR-323-3p as a candidate marker for phenotypic differentiation in FRDA patients suffering from cardiomyopathy. We propose the use of dynamic miRNAs as biomarkers for phenotypic characterization and prognosis of FRDA.

Published
2017
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8. DOP66 Ileal resections from fibrotic-CD patients present microbiota dysbiosis, altered metabolomic profiles and metabolite-sensing GPCRs expression

Author

C Bauset, M Carda-Diéguez, E Buetas, L Lis-López, M Seco-Cervera, S Coll, D Ortiz-Masiá, S Calatayud, M D Barrachina, Á Mira, and J Cosín-Roger

Subjects
Gastroenterology, General Medicine
Abstract

Background Crohn’s Disease (CD) is a subtype of IBD characterized by a chronic transmural inflammation of the gastrointestinal tract associated with several complications being intestinal fibrosis the most frequent. CD patients present microbiota dysbiosis and altered metabolomic profiles. GPCRs constitute a family of receptors which could be involved in inflammatory and fibrotic processes associated to CD. We aim to characterize microbiota composition, tissue metabolomic profile and metabolite-sensing GPCRs expression in ileal resections from fibrotic CD patients. Methods Ileal resections from B2-CD (n=21) and non-IBD (n=13) patients were obtained. Microbiota characterization was performed by 16S rRNA gene Illumina Miseq sequencing. Bioinformatic analysis of sequencing data was performed using constrained correspondence analysis and non-parametric Wilcoxon test to compare species proportions. Bacterial load was estimated by qPCR. Metabolomic analysis was performed by NMR. Results are expressed as μg metabolite/g tissue. Murine intestinal fibrosis was induced in C67BL/6 mice by: a) the heterotopic intestinal transplant model and b) chronic administration of 4 cycles of increasing DSS percentages. Gene expression of GPCRs was analyzed by qPCR. Data were expressed as fold induction vs control (mean±SEM) and compared by a t-test. Correlations were analyzed with the Spearman coefficient. Results First, microbiota analysis revealed a reduction in bacterial diversity and load in fibrotic CD patients. Then, in B2-CD samples we found at genus level Enterococcus genera significantly decreased and at species level Ruminococcus bromii and Faecalibacterium prausnitzii also reduced compared to controls. From the metabolomic analysis, altered levels of metabolites were found in ileal resections from fibrotic CD patients as summarized in Table 1. Next, B2-CD patients exhibited differential expression of metabolite-sensing GPCRs vs non-IBD as shown in Table 2. Moreover, gene expression of fibrotic markers was analyzed in B2-CD patients and significantly increased levels of COL1A1 (13.22±4.38), COL3A1 (1.84±0.52), and COL4A1(7.75±2.19), were found vs controls. Of interest, GPR81, GPR84, GPR4 and GPR68 positively correlated with profibrotic markers, specifically with COL1A1 and COL4A1. Finally, in line with human results, we also analyzed the expression of metabolite-sensing GPCRs in two different murine colitis models and results obtained are represented in Table 3. Conclusion Fibrotic CD patients exhibit microbial dysbiosis, joined with altered levels of metabolites and gene expression of metabolite-sensing GPCRs, which are also affected in murine colitis models. Their correlation with profibrotic markers points them as protagonists of intestinal fibrosis.

Published
2023
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9. Two Synthetic Approaches to Coinage Metal(I) Mesocates: Electrochemical versus Chemical Synthesis

Author

Sandra Fernández-Fariña, Miguel Martínez-Calvo, Marcelino Maneiro, José M. Seco, Guillermo Zaragoza, Ana M. González-Noya, Rosa Pedrido, Universidade de Santiago de Compostela. Departamento de Química Inorgánica, and Universidade de Santiago de Compostela. Departamento de Química Orgánica

Subjects
Ions, Inorganic Chemistry, Silver, Metals, Gold, Physical and Theoretical Chemistry, Ligands
Abstract

We report two different approaches to isolate neutral and cationic mesocate-type metallosupramolecular architectures derived from coinage monovalent ions. For this purpose, we use a thiocarbohydrazone ligand, H2L (1), conveniently tuned with bulky phosphine groups to stabilize the MI ions and prevent ligand crossing to achieve the selective formation of mesocates. The neutral complexes [Cu2(HL)2] (2), [Ag2(HL)2] (3), and [Au2(HL)2] (4) were prepared by an electrochemical method, while the cationic complexes [Cu2(H2L)2](PF6)2 (5), [Cu2(H2L)2](BF4)2 (6), [Ag2(H2L)2](PF6)2 (7), [Ag4(HL)2](NO3)2 (8), and [Au2(H2L)2]Cl2 (9) were obtained by using a metal salt as the precursor. All of the complexes are neutral or cationic dinuclear mesocates, except the silver nitrate derivative, which exhibits a tetranuclear cluster mesocate architecture. The crystal structures of the neutral and cationic copper(I), silver(I), and gold(I) complexes allow us to analyze the influence of synthetic methodology or the counterion role on both the micro- and macrostructures of the mesocates The research leading to these results received funding from FEDER-cofounded grants from Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia [Grants 2017GRCGI-1682 (ED431C2017/01), 2018GRCGI-1584 (ED431C2018/13), and MetalBIONetwork (ED431D2017/01)], from Ministerio de Ciencia, Innovación y Universidades, METALBIO (Grant CTQ2017-90802-REDT), and from Ministerio de Ciencia e Innovación, MultiMetDRUGS (Grant RED2018-102471-T) and Project PID2021-127531NB-I00 (AEI/10.13039/501100011033/FEDER, UE) SI

Published
2022
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10. Exploring the Slow Magnetic Relaxation of a Family of Photoluminescent 3D Lanthanide–Organic Frameworks Based on Dicarboxylate Ligands

Author

Itziar Oyarzabal, Sara Rojas, Ana D. Parejo, Alfonso Salinas-Castillo, José Ángel García, José M. Seco, Javier Cepeda, and Antonio Rodríguez-Diéguez

Subjects
lanthanide–organic frameworks, 9,10-anthracenedicarboxylate, 2,5-diaminoterephthalate, dinuclear building unit, photoluminescence, slow relaxation of magnetization, Chemistry, QD1-999
Abstract

A family of metal–organic frameworks with general formula {[Nd2(ant)2((NH2)2-bdc)(DMF)4]·2DMF}n (1) and {[Ln2(ant)2((NH2)2-bdc)(DMF)4]·2DMF·2H2O}n (Ln = Tb (2), Ho (3), and Er (4)) has been obtained from reactions between 9,10-anthracenedicarboxylic (H2ant) and 2,5-diaminoterephthalic ((NH2)2-H2bdc) acids, and lanthanide ions in dimethylformamide (DMF). These lanthanide–organic frameworks (LnOFs) have been characterized, and their crystal structures have been elucidated by single crystal and powder X-ray diffraction methods (on the basis of a comparative refinement with similar structures), respectively for 1 and 2–4. All LnOFs present three-dimensional structures composed of dinuclear [Ln2(µ-CO2)4] entities linked through both carboxylate ligands that yield open frameworks in which DMF and water molecules are located in the channels. Magnetic studies of these LnOFs have revealed slow relaxation of the magnetization for the Nd-based counterpart. The compounds also acknowledge relevant photoluminescence (PL) emissions in the visible (for the Tb-based homologue) and near-infrared (for the Nd- and Er-based compounds) regions. The strong green emission yielded by compound 2 at room temperature allows its study for photoluminescence (PL) sensing of various solvent molecules, finding a particular discrimination for acetone.

Published
2021
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11. Magnetic and Luminescent Properties of Isostructural 2D Coordination Polymers Based on 2-Pyrimidinecarboxylate and Lanthanide Ions

Author

Amalia García-García, Andoni Zabala-Lekuona, Ainhoa Goñi-Cárdenas, Javier Cepeda, José M. Seco, Alfonso Salinas-Castillo, Duane Choquesillo-Lazarte, and Antonio Rodríguez-Diéguez

Subjects
coordination polymer, pyrimidine-2-carboxylate, lanthanide, luminescence, magnetism, Crystallography, QD901-999
Abstract

A couple of isostructural coordination polymers with the general formula [Ln4(pymca)4(AcO)8]n have been obtained from reactions between pyrimidine-2-carboxylate (pymca) ligand and rare-earth ions (Ln = Dy (1), Nd (2)). These two-dimensional compounds have been characterized and the crystal structures have been solved by single-crystal X-ray diffraction technique, resulting in layers along the bc plane based on pymca and acetate anions that act as bridging ligands between metal atoms. Given that pymca and acetate anions possess carboxylate and hetero-nitrogen groups, it is possible to build a coordination polymer whose metal centers have a nine coordination. Furthermore, static and dynamic magnetic measurements of compound 1 reveal the lack of single molecule-magnet (SMM) behavior in this system due to the following two effects: (i) the ligand field does not stabilize magnetic ground states well separated from excited states, and (ii) anisotropy axes are not collinear, according to results with Magellan software. On another level, luminescent properties of compounds 1 and 2 are attributed to singlet π-π* transitions centered on pymca ligand as corroborated by time-dependent density functional theory (TD-DFT) calculations.

Published
2020
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12. Magneto-thermal properties and slow magnetic relaxation in Mn(<scp>ii</scp>)Ln(<scp>iii</scp>) complexes: influence of magnetic coupling on the magneto-caloric effect

Author

Itziar Oyarzabal, Andoni Zabala-Lekuona, Antonio J. Mota, María A. Palacios, Antonio Rodríguez-Diéguez, Giulia Lorusso, Marco Evangelisti, Corina Rodríguez-Esteban, Euan K. Brechin, José M. Seco, Enrique Colacio, Junta de Andalucía, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Universidad de Granada, Universidad del País Vasco, Gobierno de Aragón, and European Commission

Subjects
Inorganic Chemistry
Abstract

A family of Mn(II)Ln(III) dinuclear and tetranuclear complexes (Ln = Gd and Dy) has been prepared from the compartmental ligands N,N′-dimethyl-N,N′-bis(2-hydroxy-3-formyl-5-bromobenzyl)ethylenediamine (H2L1) and N,N′,N′′-trimethyl-N,N′′-bis(2-hydroxy-3-methoxy-5-methylbenzyl)diethylenetriamine (H2L2). The Mn(II)Gd(III) complexes exhibit antiferromagnetic interactions between Mn(II) and Gd(III) ions in most cases, which are supported by Density Functional Theory (DFT) calculations. Experimental magneto-structural correlations carried out for the reported complexes and other related complexes found in bibliography show that the highest ferromagnetic coupling constants are observed in di-μ-phenoxido bridged complexes, which is due to the planarity of the Mn–(μ-O)2–Gd bridging fragment and to the high Mn–O–Gd angles. The effect of these angles has been studied by DFT calculations performed on a di-μ-phenoxido doubly bridged model. The magneto-thermal properties of the Mn(II)Gd(III) based complexes have also been measured, concluding that the magnitude of the Magneto-Caloric Effect (MCE) is due to the strength rather than to the nature of the magnetic coupling. Moreover, when two Mn(II)Gd(III) dinuclear units are connected by two carbonato-bridging ligands the MCE is enhanced, obtaining a maximum magnetic entropy change of 36.4 Jkg−1 K−1 at ΔB = 7 T and T = 2.2 K. On the other hand, one of the dinuclear Mn(II)Dy(III) complexes displays Single-Molecule Magnet (SMM) behaviour with an energy barrier of 14.8 K under an applied external field of 1000 Oe., This work was supported by the Junta de Andalucía (FQM-195 and the Project I + D + i FEDER 2018, A-FQM-172-UGR), MICIU of Spain (Projects PGC2018-102052-B-C21 and RTI2018-098537-B-C22), the University of Granada, the University of The Basque Country UPV/EHU (GIU20/028) and the Gobierno de Aragón (E11 20R). We would like to thank the Centro de Supercomputación de la Universidad de Granada for computational resources. The authors acknowledge the technical and human support provided by SGIker of UPV/EHU and European funding (ERDF and ESF).

Published
2022
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13. Conversion of a double-tetranuclear cluster silver helicate into a dihelicate via a rare desulfurization process

Author

Sandra Fernández-Fariña, Luis M. González-Barcia, María J. Romero, Javier García-Tojal, Marcelino Maneiro, José M. Seco, Guillermo Zaragoza, Miguel Martínez-Calvo, Ana M. González-Noya, and Rosa Pedrido

Subjects
Inorganic Chemistry, Chemistry, Inorganic, Química inorgánica
Abstract

We present the first example of a silver double-tetranuclear cluster helicate [Ag4L2]2 obtained from a bisthiosemicarbazone ligand using electrochemical synthesis. This cluster helicate undergoes a rare desulfurization process in chloroform giving rise to a cationic silver dihelicate [Ag2(H2L)2]SO4. This is the first silver mediated desulfurization reaction., FEDER cofunded-grants: from Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia, 2017 GRC GI-1682 (ED431C 2017/01), 2018 GRC GI-1584 (ED431C 2018/13), MetalBIO Network (ED431D 2017/01), Ministerio de Ciencia, Innovación y Universidades, METALBIO (CTQ2017-90802-REDT) and MultiMetDrugs (RED2018-102471-T).

Published
2022
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14. The TRASGO Project. Present Status and Results

Author

D. García-Castro, M. Ajoor, H. Alvarez-Pol, A. Blanco, P. Cabanelas, J. Callón-Rivas, J. Collazo, F. Clemencio, J. J. Cuenca-García, M. Cruces, P. Fonte, Y. Fontenla, J. Flores, J. A. Garzón, A. Gomis-Moreno, A. Iglesias, G. Kornakov, T. Kurtukian-Nieto, L. Lopes, C. Loureiro, A. Pazos, C. Rodríguez, J. P. Saraiva, M. Seco, M. Valladares, V. Villasante-Marcos, and J. Xuna

Subjects
Nuclear and High Energy Physics, Atomic and Molecular Physics, and Optics
Published
2021
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15. Determination of γ and −2βs from charmless two-body decays of beauty mesons

Author

R. Aaij, C. Abellán Beteta, B. Adeva, M. Adinolfi, A. Affolder, Z. Ajaltouni, S. Akar, J. Albrecht, F. Alessio, M. Alexander, S. Ali, G. Alkhazov, P. Alvarez Cartelle, A.A. Alves, Jr, S. Amato, S. Amerio, Y. Amhis, L. An, L. Anderlini, J. Anderson, R. Andreassen, M. Andreotti, J.E. Andrews, R.B. Appleby, O. Aquines Gutierrez, F. Archilli, A. Artamonov, M. Artuso, E. Aslanides, G. Auriemma, M. Baalouch, S. Bachmann, J.J. Back, A. Badalov, C. Baesso, W. Baldini, R.J. Barlow, C. Barschel, S. Barsuk, W. Barter, V. Batozskaya, V. Battista, A. Bay, L. Beaucourt, J. Beddow, F. Bedeschi, I. Bediaga, S. Belogurov, K. Belous, I. Belyaev, E. Ben-Haim, G. Bencivenni, S. Benson, J. Benton, A. Berezhnoy, R. Bernet, M.-O. Bettler, M. van Beuzekom, A. Bien, S. Bifani, T. Bird, A. Bizzeti, P.M. Bjørnstad, T. Blake, F. Blanc, J. Blouw, S. Blusk, V. Bocci, A. Bondar, N. Bondar, W. Bonivento, S. Borghi, A. Borgia, M. Borsato, T.J.V. Bowcock, E. Bowen, C. Bozzi, T. Brambach, J. Bressieux, D. Brett, M. Britsch, T. Britton, J. Brodzicka, N.H. Brook, H. Brown, A. Bursche, G. Busetto, J. Buytaert, S. Cadeddu, R. Calabrese, M. Calvi, M. Calvo Gomez, P. Campana, D. Campora Perez, A. Carbone, G. Carboni, R. Cardinale, A. Cardini, L. Carson, K. Carvalho Akiba, G. Casse, L. Cassina, L. Castillo Garcia, M. Cattaneo, Ch. Cauet, R. Cenci, M. Charles, Ph. Charpentier, M. Chefdeville, S. Chen, S.-F. Cheung, N. Chiapolini, M. Chrzaszcz, K. Ciba, X. Cid Vidal, G. Ciezarek, P.E.L. Clarke, M. Clemencic, H.V. Cliff, J. Closier, V. Coco, J. Cogan, E. Cogneras, L. Cojocariu, P. Collins, A. Comerma-Montells, A. Contu, A. Cook, M. Coombes, S. Coquereau, G. Corti, M. Corvo, I. Counts, B. Couturier, G.A. Cowan, D.C. Craik, M. Cruz Torres, S. Cunliffe, R. Currie, C. D'Ambrosio, J. Dalseno, P. David, P.N.Y. David, A. Davis, K. De Bruyn, S. De Capua, M. De Cian, J.M. De Miranda, L. De Paula, W. De Silva, P. De Simone, D. Decamp, M. Deckenhoff, L. Del Buono, N. Déléage, D. Derkach, O. Deschamps, F. Dettori, A. Di Canto, H. Dijkstra, S. Donleavy, F. Dordei, M. Dorigo, A. Dosil Suárez, D. Dossett, A. Dovbnya, K. Dreimanis, G. Dujany, F. Dupertuis, P. Durante, R. Dzhelyadin, A. Dziurda, A. Dzyuba, S. Easo, V. Egorychev, S. Eidelman, S. Eisenhardt, U. Eitschberger, R. Ekelhof, L. Eklund, I. El Rifai, Ch. Elsasser, S. Ely, S. Esen, H.-M. Evans, T. Evans, A. Falabella, C. Färber, C. Farinelli, N. Farley, S. Farry, R.F. Fay, D. Ferguson, V. Fernandez Albor, F. Ferreira Rodrigues, M. Ferro-Luzzi, S. Filippov, M. Fiore, M. Fiorini, M. Firlej, C. Fitzpatrick, T. Fiutowski, P. Fol, M. Fontana, F. Fontanelli, R. Forty, O. Francisco, M. Frank, C. Frei, M. Frosini, J. Fu, E. Furfaro, A. Gallas Torreira, D. Galli, S. Gallorini, S. Gambetta, M. Gandelman, P. Gandini, Y. Gao, J. García Pardiñas, J. Garofoli, J. Garra Tico, L. Garrido, C. Gaspar, R. Gauld, L. Gavardi, G. Gavrilov, A. Geraci, E. Gersabeck, M. Gersabeck, T. Gershon, Ph. Ghez, A. Gianelle, S. Gianì, V. Gibson, L. Giubega, V.V. Gligorov, C. Göbel, D. Golubkov, A. Golutvin, A. Gomes, C. Gotti, M. Grabalosa Gándara, R. Graciani Diaz, L.A. Granado Cardoso, E. Graugés, G. Graziani, A. Grecu, E. Greening, S. Gregson, P. Griffith, L. Grillo, O. Grünberg, B. Gui, E. Gushchin, Yu. Guz, T. Gys, C. Hadjivasiliou, G. Haefeli, C. Haen, S.C. Haines, S. Hall, B. Hamilton, T. Hampson, X. Han, S. Hansmann-Menzemer, N. Harnew, S.T. Harnew, J. Harrison, J. He, T. Head, V. Heijne, K. Hennessy, P. Henrard, L. Henry, J.A. Hernando Morata, E. van Herwijnen, M. Heß, A. Hicheur, D. Hill, M. Hoballah, C. Hombach, W. Hulsbergen, P. Hunt, N. Hussain, D. Hutchcroft, D. Hynds, M. Idzik, P. Ilten, R. Jacobsson, A. Jaeger, J. Jalocha, E. Jans, P. Jaton, A. Jawahery, F. Jing, M. John, D. Johnson, C.R. Jones, C. Joram, B. Jost, N. Jurik, M. Kaballo, S. Kandybei, W. Kanso, M. Karacson, T.M. Karbach, S. Karodia, M. Kelsey, I.R. Kenyon, T. Ketel, B. Khanji, C. Khurewathanakul, S. Klaver, K. Klimaszewski, O. Kochebina, M. Kolpin, I. Komarov, R.F. Koopman, P. Koppenburg, M. Korolev, A. Kozlinskiy, L. Kravchuk, K. Kreplin, M. Kreps, G. Krocker, P. Krokovny, F. Kruse, W. Kucewicz, M. Kucharczyk, V. Kudryavtsev, K. Kurek, T. Kvaratskheliya, V.N. La Thi, D. Lacarrere, G. Lafferty, A. Lai, D. Lambert, R.W. Lambert, G. Lanfranchi, C. Langenbruch, B. Langhans, T. Latham, C. Lazzeroni, R. Le Gac, J. van Leerdam, J.-P. Lees, R. Lefèvre, A. Leflat, J. Lefrançois, S. Leo, O. Leroy, T. Lesiak, B. Leverington, Y. Li, T. Likhomanenko, M. Liles, R. Lindner, C. Linn, F. Lionetto, B. Liu, S. Lohn, I. Longstaff, J.H. Lopes, N. Lopez-March, P. Lowdon, H. Lu, D. Lucchesi, H. Luo, A. Lupato, E. Luppi, O. Lupton, F. Machefert, I.V. Machikhiliyan, F. Maciuc, O. Maev, S. Malde, A. Malinin, G. Manca, G. Mancinelli, A. Mapelli, J. Maratas, J.F. Marchand, U. Marconi, C. Marin Benito, P. Marino, R. Märki, J. Marks, G. Martellotti, A. Martens, A. Martín Sánchez, M. Martinelli, D. Martinez Santos, F. Martinez Vidal, D. Martins Tostes, A. Massafferri, R. Matev, Z. Mathe, C. Matteuzzi, A. Mazurov, M. McCann, J. McCarthy, A. McNab, R. McNulty, B. McSkelly, B. Meadows, F. Meier, M. Meissner, M. Merk, D.A. Milanes, M.-N. Minard, N. Moggi, J. Molina Rodriguez, S. Monteil, M. Morandin, P. Morawski, A. Mordà, M.J. Morello, J. Moron, A.-B. Morris, R. Mountain, F. Muheim, K. Müller, M. Mussini, B. Muster, P. Naik, T. Nakada, R. Nandakumar, I. Nasteva, M. Needham, N. Neri, S. Neubert, N. Neufeld, M. Neuner, A.D. Nguyen, T.D. Nguyen, C. Nguyen-Mau, M. Nicol, V. Niess, R. Niet, N. Nikitin, T. Nikodem, A. Novoselov, D.P. O'Hanlon, A. Oblakowska-Mucha, V. Obraztsov, S. Oggero, S. Ogilvy, O. Okhrimenko, R. Oldeman, G. Onderwater, M. Orlandea, J.M. Otalora Goicochea, P. Owen, A. Oyanguren, B.K. Pal, A. Palano, F. Palombo, M. Palutan, J. Panman, A. Papanestis, M. Pappagallo, L.L. Pappalardo, C. Parkes, C.J. Parkinson, G. Passaleva, G.D. Patel, M. Patel, C. Patrignani, A. Pazos Alvarez, A. Pearce, A. Pellegrino, M. Pepe Altarelli, S. Perazzini, E. Perez Trigo, P. Perret, M. Perrin-Terrin, L. Pescatore, E. Pesen, K. Petridis, A. Petrolini, E. Picatoste Olloqui, B. Pietrzyk, T. Pilař, D. Pinci, A. Pistone, S. Playfer, M. Plo Casasus, F. Polci, A. Poluektov, E. Polycarpo, A. Popov, D. Popov, B. Popovici, C. Potterat, E. Price, J.D. Price, J. Prisciandaro, A. Pritchard, C. Prouve, V. Pugatch, A. Puig Navarro, G. Punzi, W. Qian, B. Rachwal, J.H. Rademacker, B. Rakotomiaramanana, M. Rama, M.S. Rangel, I. Raniuk, N. Rauschmayr, G. Raven, F. Redi, S. Reichert, M.M. Reid, A.C. dos Reis, S. Ricciardi, S. Richards, M. Rihl, K. Rinnert, V. Rives Molina, P. Robbe, A.B. Rodrigues, E. Rodrigues, P. Rodriguez Perez, S. Roiser, V. Romanovsky, A. Romero Vidal, M. Rotondo, J. Rouvinet, T. Ruf, H. Ruiz, P. Ruiz Valls, J.J. Saborido Silva, N. Sagidova, P. Sail, B. Saitta, V. Salustino Guimaraes, C. Sanchez Mayordomo, B. Sanmartin Sedes, R. Santacesaria, C. Santamarina Rios, E. Santovetti, A. Sarti, C. Satriano, A. Satta, D.M. Saunders, M. Savrie, D. Savrina, M. Schiller, H. Schindler, M. Schlupp, M. Schmelling, B. Schmidt, O. Schneider, A. Schopper, M.-H. Schune, R. Schwemmer, B. Sciascia, A. Sciubba, M. Seco, A. Semennikov, I. Sepp, N. Serra, J. Serrano, L. Sestini, P. Seyfert, M. Shapkin, I. Shapoval, Y. Shcheglov, T. Shears, L. Shekhtman, V. Shevchenko, A. Shires, R. Silva Coutinho, G. Simi, M. Sirendi, N. Skidmore, T. Skwarnicki, N.A. Smith, E. Smith, J. Smith, M. Smith, H. Snoek, M.D. Sokoloff, F.J.P. Soler, F. Soomro, D. Souza, B. Souza De Paula, B. Spaan, A. Sparkes, P. Spradlin, S. Sridharan, F. Stagni, M. Stahl, S. Stahl, O. Steinkamp, O. Stenyakin, S. Stevenson, S. Stoica, S. Stone, B. Storaci, S. Stracka, M. Straticiuc, U. Straumann, R. Stroili, V.K. Subbiah, L. Sun, W. Sutcliffe, K. Swientek, S. Swientek, V. Syropoulos, M. Szczekowski, P. Szczypka, D. Szilard, T. Szumlak, S. T'Jampens, M. Teklishyn, G. Tellarini, F. Teubert, C. Thomas, E. Thomas, J. van Tilburg, V. Tisserand, M. Tobin, S. Tolk, L. Tomassetti, S. Topp-Joergensen, N. Torr, E. Tournefier, S. Tourneur, M.T. Tran, M. Tresch, A. Tsaregorodtsev, P. Tsopelas, N. Tuning, M. Ubeda Garcia, A. Ukleja, A. Ustyuzhanin, U. Uwer, C. Vacca, V. Vagnoni, G. Valenti, A. Vallier, R. Vazquez Gomez, P. Vazquez Regueiro, C. Vázquez Sierra, S. Vecchi, J.J. Velthuis, M. Veltri, G. Veneziano, M. Vesterinen, B. Viaud, D. Vieira, M. Vieites Diaz, X. Vilasis-Cardona, A. Vollhardt, D. Volyanskyy, D. Voong, A. Vorobyev, V. Vorobyev, C. Voß, H. Voss, J.A. de Vries, R. Waldi, C. Wallace, R. Wallace, J. Walsh, S. Wandernoth, J. Wang, D.R. Ward, N.K. Watson, D. Websdale, M. Whitehead, J. Wicht, D. Wiedner, G. Wilkinson, M.P. Williams, M. Williams, H.W. Wilschut, F.F. Wilson, J. Wimberley, J. Wishahi, W. Wislicki, M. Witek, G. Wormser, S.A. Wotton, S. Wright, K. Wyllie, Y. Xie, Z. Xing, Z. Xu, Z. Yang, X. Yuan, O. Yushchenko, M. Zangoli, M. Zavertyaev, L. Zhang, W.C. Zhang, Y. Zhang, A. Zhelezov, A. Zhokhov, L. Zhong, and A. Zvyagin

Subjects
Physics, QC1-999
Abstract

Using the latest LHCb measurements of time-dependent CP violation in the Bs0→K+K− decay, a U-spin relation between the decay amplitudes of Bs0→K+K− and B0→π+π− decay processes allows constraints to be placed on the angle γ of the unitarity triangle and on the Bs0 mixing phase −2βs. Results from an extended approach, which uses additional inputs on B0→π0π0 and B+→π+π0 decays from other experiments and exploits isospin symmetry, are also presented. The dependence of the results on the maximum allowed amount of U-spin breaking is studied. At 68% probability, the value γ=(63.5−6.7+7.2)° modulo 180° is determined. In an alternative analysis, the value −2βs=−0.12−0.16+0.14 rad is found. In both measurements, the uncertainties due to U-spin breaking effects up to 50% are included.

Published
2015
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17. Measurement of the B¯0–B0 and B¯s0–Bs0 production asymmetries in pp collisions at s=7 TeV

Author

R. Aaij, B. Adeva, M. Adinolfi, A. Affolder, Z. Ajaltouni, S. Akar, J. Albrecht, F. Alessio, M. Alexander, S. Ali, G. Alkhazov, P. Alvarez Cartelle, A.A. Alves, Jr., S. Amato, S. Amerio, Y. Amhis, L. An, L. Anderlini, J. Anderson, R. Andreassen, M. Andreotti, J.E. Andrews, R.B. Appleby, O. Aquines Gutierrez, F. Archilli, A. Artamonov, M. Artuso, E. Aslanides, G. Auriemma, M. Baalouch, S. Bachmann, J.J. Back, A. Badalov, W. Baldini, R.J. Barlow, C. Barschel, S. Barsuk, W. Barter, V. Batozskaya, V. Battista, A. Bay, L. Beaucourt, J. Beddow, F. Bedeschi, I. Bediaga, S. Belogurov, K. Belous, I. Belyaev, E. Ben-Haim, G. Bencivenni, S. Benson, J. Benton, A. Berezhnoy, R. Bernet, M.-O. Bettler, M. van Beuzekom, A. Bien, S. Bifani, T. Bird, A. Bizzeti, P.M. Bjørnstad, T. Blake, F. Blanc, J. Blouw, S. Blusk, V. Bocci, A. Bondar, N. Bondar, W. Bonivento, S. Borghi, A. Borgia, M. Borsato, T.J.V. Bowcock, E. Bowen, C. Bozzi, T. Brambach, J. van den Brand, J. Bressieux, D. Brett, M. Britsch, T. Britton, J. Brodzicka, N.H. Brook, H. Brown, A. Bursche, G. Busetto, J. Buytaert, S. Cadeddu, R. Calabrese, M. Calvi, M. Calvo Gomez, P. Campana, D. Campora Perez, A. Carbone, G. Carboni, R. Cardinale, A. Cardini, L. Carson, K. Carvalho Akiba, G. Casse, L. Cassina, L. Castillo Garcia, M. Cattaneo, Ch. Cauet, R. Cenci, M. Charles, Ph. Charpentier, M. Chefdeville, S. Chen, S.-F. Cheung, N. Chiapolini, M. Chrzaszcz, K. Ciba, X. Cid Vidal, G. Ciezarek, P.E.L. Clarke, M. Clemencic, H.V. Cliff, J. Closier, V. Coco, J. Cogan, E. Cogneras, L. Cojocariu, P. Collins, A. Comerma-Montells, A. Contu, A. Cook, M. Coombes, S. Coquereau, G. Corti, M. Corvo, I. Counts, B. Couturier, G.A. Cowan, D.C. Craik, M. Cruz Torres, S. Cunliffe, R. Currie, C. D'Ambrosio, J. Dalseno, P. David, P.N.Y. David, A. Davis, K. De Bruyn, S. De Capua, M. De Cian, J.M. De Miranda, L. De Paula, W. De Silva, P. De Simone, D. Decamp, M. Deckenhoff, L. Del Buono, N. Déléage, D. Derkach, O. Deschamps, F. Dettori, A. Di Canto, H. Dijkstra, S. Donleavy, F. Dordei, M. Dorigo, A. Dosil Suárez, D. Dossett, A. Dovbnya, K. Dreimanis, G. Dujany, F. Dupertuis, P. Durante, R. Dzhelyadin, A. Dziurda, A. Dzyuba, S. Easo, U. Egede, V. Egorychev, S. Eidelman, S. Eisenhardt, U. Eitschberger, R. Ekelhof, L. Eklund, I. El Rifai, Ch. Elsasser, S. Ely, S. Esen, H.-M. Evans, T. Evans, A. Falabella, C. Färber, C. Farinelli, N. Farley, S. Farry, R.F. Fay, D. Ferguson, V. Fernandez Albor, F. Ferreira Rodrigues, M. Ferro-Luzzi, S. Filippov, M. Fiore, M. Fiorini, M. Firlej, C. Fitzpatrick, T. Fiutowski, M. Fontana, F. Fontanelli, R. Forty, O. Francisco, M. Frank, C. Frei, M. Frosini, J. Fu, E. Furfaro, A. Gallas Torreira, D. Galli, S. Gallorini, S. Gambetta, M. Gandelman, P. Gandini, Y. Gao, J. García Pardiñas, J. Garofoli, J. Garra Tico, L. Garrido, C. Gaspar, R. Gauld, L. Gavardi, G. Gavrilov, A. Geraci, E. Gersabeck, M. Gersabeck, T. Gershon, Ph. Ghez, A. Gianelle, S. Giani', V. Gibson, L. Giubega, V.V. Gligorov, C. Göbel, D. Golubkov, A. Golutvin, A. Gomes, C. Gotti, M. Grabalosa Gándara, R. Graciani Diaz, L.A. Granado Cardoso, E. Graugés, G. Graziani, A. Grecu, E. Greening, S. Gregson, P. Griffith, L. Grillo, O. Grünberg, B. Gui, E. Gushchin, Yu. Guz, T. Gys, C. Hadjivasiliou, G. Haefeli, C. Haen, S.C. Haines, S. Hall, B. Hamilton, T. Hampson, X. Han, S. Hansmann-Menzemer, N. Harnew, S.T. Harnew, J. Harrison, J. He, T. Head, V. Heijne, K. Hennessy, P. Henrard, L. Henry, J.A. Hernando Morata, E. van Herwijnen, M. Heß, A. Hicheur, D. Hill, M. Hoballah, C. Hombach, W. Hulsbergen, P. Hunt, N. Hussain, D. Hutchcroft, D. Hynds, M. Idzik, P. Ilten, R. Jacobsson, A. Jaeger, J. Jalocha, E. Jans, P. Jaton, A. Jawahery, F. Jing, M. John, D. Johnson, C.R. Jones, C. Joram, B. Jost, N. Jurik, M. Kaballo, S. Kandybei, W. Kanso, M. Karacson, T.M. Karbach, S. Karodia, M. Kelsey, I.R. Kenyon, T. Ketel, B. Khanji, C. Khurewathanakul, S. Klaver, K. Klimaszewski, O. Kochebina, M. Kolpin, I. Komarov, R.F. Koopman, P. Koppenburg, M. Korolev, A. Kozlinskiy, L. Kravchuk, K. Kreplin, M. Kreps, G. Krocker, P. Krokovny, F. Kruse, W. Kucewicz, M. Kucharczyk, V. Kudryavtsev, K. Kurek, T. Kvaratskheliya, V.N. La Thi, D. Lacarrere, G. Lafferty, A. Lai, D. Lambert, R.W. Lambert, G. Lanfranchi, C. Langenbruch, B. Langhans, T. Latham, C. Lazzeroni, R. Le Gac, J. van Leerdam, J.-P. Lees, R. Lefèvre, A. Leflat, J. Lefrançois, S. Leo, O. Leroy, T. Lesiak, B. Leverington, Y. Li, T. Likhomanenko, M. Liles, R. Lindner, C. Linn, F. Lionetto, B. Liu, S. Lohn, I. Longstaff, J.H. Lopes, N. Lopez-March, P. Lowdon, H. Lu, D. Lucchesi, H. Luo, A. Lupato, E. Luppi, O. Lupton, F. Machefert, I.V. Machikhiliyan, F. Maciuc, O. Maev, S. Malde, A. Malinin, G. Manca, G. Mancinelli, A. Mapelli, J. Maratas, J.F. Marchand, U. Marconi, C. Marin Benito, P. Marino, R. Märki, J. Marks, G. Martellotti, A. Martens, A. Martín Sánchez, M. Martinelli, D. Martinez Santos, F. Martinez Vidal, D. Martins Tostes, A. Massafferri, R. Matev, Z. Mathe, C. Matteuzzi, A. Mazurov, M. McCann, J. McCarthy, A. McNab, R. McNulty, B. McSkelly, B. Meadows, F. Meier, M. Meissner, M. Merk, D.A. Milanes, M.-N. Minard, N. Moggi, J. Molina Rodriguez, S. Monteil, M. Morandin, P. Morawski, A. Mordà, M.J. Morello, J. Moron, A.-B. Morris, R. Mountain, F. Muheim, K. Müller, M. Mussini, B. Muster, P. Naik, T. Nakada, R. Nandakumar, I. Nasteva, M. Needham, N. Neri, S. Neubert, N. Neufeld, M. Neuner, A.D. Nguyen, T.D. Nguyen, C. Nguyen-Mau, M. Nicol, V. Niess, R. Niet, N. Nikitin, T. Nikodem, A. Novoselov, D.P. O'Hanlon, A. Oblakowska-Mucha, V. Obraztsov, S. Oggero, S. Ogilvy, O. Okhrimenko, R. Oldeman, G. Onderwater, M. Orlandea, J.M. Otalora Goicochea, P. Owen, A. Oyanguren, B.K. Pal, A. Palano, F. Palombo, M. Palutan, J. Panman, A. Papanestis, M. Pappagallo, L.L. Pappalardo, C. Parkes, C.J. Parkinson, G. Passaleva, G.D. Patel, M. Patel, C. Patrignani, A. Pazos Alvarez, A. Pearce, A. Pellegrino, M. Pepe Altarelli, S. Perazzini, E. Perez Trigo, P. Perret, M. Perrin-Terrin, L. Pescatore, E. Pesen, K. Petridis, A. Petrolini, E. Picatoste Olloqui, B. Pietrzyk, T. Pilař, D. Pinci, A. Pistone, S. Playfer, M. Plo Casasus, F. Polci, A. Poluektov, E. Polycarpo, A. Popov, D. Popov, B. Popovici, C. Potterat, E. Price, J. Prisciandaro, A. Pritchard, C. Prouve, V. Pugatch, A. Puig Navarro, G. Punzi, W. Qian, B. Rachwal, J.H. Rademacker, B. Rakotomiaramanana, M. Rama, M.S. Rangel, I. Raniuk, N. Rauschmayr, G. Raven, S. Reichert, M.M. Reid, A.C. dos Reis, S. Ricciardi, S. Richards, M. Rihl, K. Rinnert, V. Rives Molina, D.A. Roa Romero, P. Robbe, A.B. Rodrigues, E. Rodrigues, P. Rodriguez Perez, S. Roiser, V. Romanovsky, A. Romero Vidal, M. Rotondo, J. Rouvinet, T. Ruf, H. Ruiz, P. Ruiz Valls, J.J. Saborido Silva, N. Sagidova, P. Sail, B. Saitta, V. Salustino Guimaraes, C. Sanchez Mayordomo, B. Sanmartin Sedes, R. Santacesaria, C. Santamarina Rios, E. Santovetti, A. Sarti, C. Satriano, A. Satta, D.M. Saunders, M. Savrie, D. Savrina, M. Schiller, H. Schindler, M. Schlupp, M. Schmelling, B. Schmidt, O. Schneider, A. Schopper, M.-H. Schune, R. Schwemmer, B. Sciascia, A. Sciubba, M. Seco, A. Semennikov, I. Sepp, N. Serra, J. Serrano, L. Sestini, P. Seyfert, M. Shapkin, I. Shapoval, Y. Shcheglov, T. Shears, L. Shekhtman, V. Shevchenko, A. Shires, R. Silva Coutinho, G. Simi, M. Sirendi, N. Skidmore, T. Skwarnicki, N.A. Smith, E. Smith, J. Smith, M. Smith, H. Snoek, M.D. Sokoloff, F.J.P. Soler, F. Soomro, D. Souza, B. Souza De Paula, B. Spaan, A. Sparkes, P. Spradlin, S. Sridharan, F. Stagni, M. Stahl, S. Stahl, O. Steinkamp, O. Stenyakin, S. Stevenson, S. Stoica, S. Stone, B. Storaci, S. Stracka, M. Straticiuc, U. Straumann, R. Stroili, V.K. Subbiah, L. Sun, W. Sutcliffe, K. Swientek, S. Swientek, V. Syropoulos, M. Szczekowski, P. Szczypka, D. Szilard, T. Szumlak, S. T'Jampens, M. Teklishyn, G. Tellarini, F. Teubert, C. Thomas, E. Thomas, J. van Tilburg, V. Tisserand, M. Tobin, S. Tolk, L. Tomassetti, D. Tonelli, S. Topp-Joergensen, N. Torr, E. Tournefier, S. Tourneur, M.T. Tran, M. Tresch, A. Tsaregorodtsev, P. Tsopelas, N. Tuning, M. Ubeda Garcia, A. Ukleja, A. Ustyuzhanin, U. Uwer, V. Vagnoni, G. Valenti, A. Vallier, R. Vazquez Gomez, P. Vazquez Regueiro, C. Vázquez Sierra, S. Vecchi, J.J. Velthuis, M. Veltri, G. Veneziano, M. Vesterinen, B. Viaud, D. Vieira, M. Vieites Diaz, X. Vilasis-Cardona, A. Vollhardt, D. Volyanskyy, D. Voong, A. Vorobyev, V. Vorobyev, C. Voß, H. Voss, J.A. de Vries, R. Waldi, C. Wallace, R. Wallace, J. Walsh, S. Wandernoth, J. Wang, D.R. Ward, N.K. Watson, D. Websdale, M. Whitehead, J. Wicht, D. Wiedner, G. Wilkinson, M.P. Williams, M. Williams, F.F. Wilson, J. Wimberley, J. Wishahi, W. Wislicki, M. Witek, G. Wormser, S.A. Wotton, S. Wright, S. Wu, K. Wyllie, Y. Xie, Z. Xing, Z. Xu, Z. Yang, X. Yuan, O. Yushchenko, M. Zangoli, M. Zavertyaev, L. Zhang, W.C. Zhang, Y. Zhang, A. Zhelezov, A. Zhokhov, L. Zhong, and A. Zvyagin

Subjects
Physics, QC1-999
Abstract

The B¯0–B0 and B¯s0–Bs0 production asymmetries, AP(B0) and AP(Bs0), are measured by means of a time-dependent analysis of B0→J/ψK⁎0, B0→D−π+ and Bs0→Ds−π+ decays, using a data sample corresponding to an integrated luminosity of 1.0 fb−1, collected by LHCb in pp collisions at a centre-of-mass energy of 7 TeV. The measurements are performed as a function of transverse momentum and pseudorapidity of the B0 and Bs0 mesons within the LHCb acceptance. The production asymmetries, integrated over pT and η in the range 4

Published
2014
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18. Measurement of CP violation and constraints on the CKM angle γ in B±→DK± with D→KS0π+π− decays

Author

R. Aaij, B. Adeva, M. Adinolfi, A. Affolder, Z. Ajaltouni, J. Albrecht, F. Alessio, M. Alexander, S. Ali, G. Alkhazov, P. Alvarez Cartelle, A.A. Alves, Jr, S. Amato, S. Amerio, Y. Amhis, L. An, L. Anderlini, J. Anderson, R. Andreassen, M. Andreotti, J.E. Andrews, R.B. Appleby, O. Aquines Gutierrez, F. Archilli, A. Artamonov, M. Artuso, E. Aslanides, G. Auriemma, M. Baalouch, S. Bachmann, J.J. Back, A. Badalov, V. Balagura, W. Baldini, R.J. Barlow, C. Barschel, S. Barsuk, W. Barter, V. Batozskaya, A. Bay, L. Beaucourt, J. Beddow, F. Bedeschi, I. Bediaga, S. Belogurov, K. Belous, I. Belyaev, E. Ben-Haim, G. Bencivenni, S. Benson, J. Benton, A. Berezhnoy, R. Bernet, M.-O. Bettler, M. van Beuzekom, A. Bien, S. Bifani, T. Bird, A. Bizzeti, P.M. Bjørnstad, T. Blake, F. Blanc, J. Blouw, S. Blusk, V. Bocci, A. Bondar, N. Bondar, W. Bonivento, S. Borghi, A. Borgia, M. Borsato, T.J.V. Bowcock, E. Bowen, C. Bozzi, T. Brambach, J. van den Brand, J. Bressieux, D. Brett, M. Britsch, T. Britton, J. Brodzicka, N.H. Brook, H. Brown, A. Bursche, G. Busetto, J. Buytaert, S. Cadeddu, R. Calabrese, M. Calvi, M. Calvo Gomez, A. Camboni, P. Campana, D. Campora Perez, A. Carbone, G. Carboni, R. Cardinale, A. Cardini, H. Carranza-Mejia, L. Carson, K. Carvalho Akiba, G. Casse, L. Cassina, L. Castillo Garcia, M. Cattaneo, Ch. Cauet, R. Cenci, M. Charles, Ph. Charpentier, S. Chen, S.-F. Cheung, N. Chiapolini, M. Chrzaszcz, K. Ciba, X. Cid Vidal, G. Ciezarek, P.E.L. Clarke, M. Clemencic, H.V. Cliff, J. Closier, V. Coco, J. Cogan, E. Cogneras, P. Collins, A. Comerma-Montells, A. Contu, A. Cook, M. Coombes, S. Coquereau, G. Corti, M. Corvo, I. Counts, B. Couturier, G.A. Cowan, D.C. Craik, M. Cruz Torres, S. Cunliffe, R. Currie, C. D'Ambrosio, J. Dalseno, P. David, P.N.Y. David, A. Davis, K. De Bruyn, S. De Capua, M. De Cian, J.M. De Miranda, L. De Paula, W. De Silva, P. De Simone, D. Decamp, M. Deckenhoff, L. Del Buono, N. Déléage, D. Derkach, O. Deschamps, F. Dettori, A. Di Canto, H. Dijkstra, S. Donleavy, F. Dordei, M. Dorigo, A. Dosil Suárez, D. Dossett, A. Dovbnya, G. Dujany, F. Dupertuis, P. Durante, R. Dzhelyadin, A. Dziurda, A. Dzyuba, S. Easo, U. Egede, V. Egorychev, S. Eidelman, S. Eisenhardt, U. Eitschberger, R. Ekelhof, L. Eklund, I. El Rifai, Ch. Elsasser, S. Ely, S. Esen, A. Falabella, C. Färber, C. Farinelli, N. Farley, S. Farry, R.F. Fay, D. Ferguson, V. Fernandez Albor, F. Ferreira Rodrigues, M. Ferro-Luzzi, S. Filippov, M. Fiore, M. Fiorini, M. Firlej, C. Fitzpatrick, T. Fiutowski, M. Fontana, F. Fontanelli, R. Forty, O. Francisco, M. Frank, C. Frei, M. Frosini, J. Fu, E. Furfaro, A. Gallas Torreira, D. Galli, S. Gallorini, S. Gambetta, M. Gandelman, P. Gandini, Y. Gao, J. Garofoli, J. Garra Tico, L. Garrido, C. Gaspar, R. Gauld, L. Gavardi, A. Geraci, E. Gersabeck, M. Gersabeck, T. Gershon, Ph. Ghez, A. Gianelle, S. Giani', V. Gibson, L. Giubega, V.V. Gligorov, C. Göbel, D. Golubkov, A. Golutvin, A. Gomes, H. Gordon, C. Gotti, M. Grabalosa Gándara, R. Graciani Diaz, L.A. Granado Cardoso, E. Graugés, G. Graziani, A. Grecu, E. Greening, S. Gregson, P. Griffith, L. Grillo, O. Grünberg, B. Gui, E. Gushchin, Yu. Guz, T. Gys, C. Hadjivasiliou, G. Haefeli, C. Haen, S.C. Haines, S. Hall, B. Hamilton, T. Hampson, X. Han, S. Hansmann-Menzemer, N. Harnew, S.T. Harnew, J. Harrison, T. Hartmann, J. He, T. Head, V. Heijne, K. Hennessy, P. Henrard, L. Henry, J.A. Hernando Morata, E. van Herwijnen, M. Heß, A. Hicheur, D. Hill, M. Hoballah, C. Hombach, W. Hulsbergen, P. Hunt, N. Hussain, D. Hutchcroft, D. Hynds, M. Idzik, P. Ilten, R. Jacobsson, A. Jaeger, J. Jalocha, E. Jans, P. Jaton, A. Jawahery, F. Jing, M. John, D. Johnson, C.R. Jones, C. Joram, B. Jost, N. Jurik, M. Kaballo, S. Kandybei, W. Kanso, M. Karacson, T.M. Karbach, M. Kelsey, I.R. Kenyon, T. Ketel, B. Khanji, C. Khurewathanakul, S. Klaver, O. Kochebina, M. Kolpin, I. Komarov, R.F. Koopman, P. Koppenburg, M. Korolev, A. Kozlinskiy, L. Kravchuk, K. Kreplin, M. Kreps, G. Krocker, P. Krokovny, F. Kruse, M. Kucharczyk, V. Kudryavtsev, K. Kurek, T. Kvaratskheliya, V.N. La Thi, D. Lacarrere, G. Lafferty, A. Lai, D. Lambert, R.W. Lambert, E. Lanciotti, G. Lanfranchi, C. Langenbruch, B. Langhans, T. Latham, C. Lazzeroni, R. Le Gac, J. van Leerdam, J.-P. Lees, R. Lefèvre, A. Leflat, J. Lefrançois, S. Leo, O. Leroy, T. Lesiak, B. Leverington, Y. Li, M. Liles, R. Lindner, C. Linn, F. Lionetto, B. Liu, G. Liu, S. Lohn, I. Longstaff, J.H. Lopes, N. Lopez-March, P. Lowdon, H. Lu, D. Lucchesi, H. Luo, A. Lupato, E. Luppi, O. Lupton, F. Machefert, I.V. Machikhiliyan, F. Maciuc, O. Maev, S. Malde, G. Manca, G. Mancinelli, A. Mapelli, J. Maratas, J.F. Marchand, U. Marconi, C. Marin Benito, P. Marino, R. Märki, J. Marks, G. Martellotti, A. Martens, A. Martín Sánchez, M. Martinelli, D. Martinez Santos, F. Martinez Vidal, D. Martins Tostes, A. Massafferri, R. Matev, Z. Mathe, C. Matteuzzi, A. Mazurov, M. McCann, J. McCarthy, A. McNab, R. McNulty, B. McSkelly, B. Meadows, F. Meier, M. Meissner, M. Merk, D.A. Milanes, M.-N. Minard, N. Moggi, J. Molina Rodriguez, S. Monteil, D. Moran, M. Morandin, P. Morawski, A. Mordà, M.J. Morello, J. Moron, A.-B. Morris, R. Mountain, F. Muheim, K. Müller, R. Muresan, M. Mussini, B. Muster, P. Naik, T. Nakada, R. Nandakumar, I. Nasteva, M. Needham, N. Neri, S. Neubert, N. Neufeld, M. Neuner, A.D. Nguyen, T.D. Nguyen, C. Nguyen-Mau, M. Nicol, V. Niess, R. Niet, N. Nikitin, T. Nikodem, A. Novoselov, A. Oblakowska-Mucha, V. Obraztsov, S. Oggero, S. Ogilvy, O. Okhrimenko, R. Oldeman, G. Onderwater, M. Orlandea, J.M. Otalora Goicochea, P. Owen, A. Oyanguren, B.K. Pal, A. Palano, F. Palombo, M. Palutan, J. Panman, A. Papanestis, M. Pappagallo, C. Parkes, C.J. Parkinson, G. Passaleva, G.D. Patel, M. Patel, C. Patrignani, A. Pazos Alvarez, A. Pearce, A. Pellegrino, M. Pepe Altarelli, S. Perazzini, E. Perez Trigo, P. Perret, M. Perrin-Terrin, L. Pescatore, E. Pesen, K. Petridis, A. Petrolini, E. Picatoste Olloqui, B. Pietrzyk, T. Pilař, D. Pinci, A. Pistone, S. Playfer, M. Plo Casasus, F. Polci, A. Poluektov, E. Polycarpo, A. Popov, D. Popov, B. Popovici, C. Potterat, A. Powell, J. Prisciandaro, A. Pritchard, C. Prouve, V. Pugatch, A. Puig Navarro, G. Punzi, W. Qian, B. Rachwal, J.H. Rademacker, B. Rakotomiaramanana, M. Rama, M.S. Rangel, I. Raniuk, N. Rauschmayr, G. Raven, S. Reichert, M.M. Reid, A.C. dos Reis, S. Ricciardi, A. Richards, M. Rihl, K. Rinnert, V. Rives Molina, D.A. Roa Romero, P. Robbe, A.B. Rodrigues, E. Rodrigues, P. Rodriguez Perez, S. Roiser, V. Romanovsky, A. Romero Vidal, M. Rotondo, J. Rouvinet, T. Ruf, F. Ruffini, H. Ruiz, P. Ruiz Valls, G. Sabatino, J.J. Saborido Silva, N. Sagidova, P. Sail, B. Saitta, V. Salustino Guimaraes, C. Sanchez Mayordomo, B. Sanmartin Sedes, R. Santacesaria, C. Santamarina Rios, E. Santovetti, M. Sapunov, A. Sarti, C. Satriano, A. Satta, M. Savrie, D. Savrina, M. Schiller, H. Schindler, M. Schlupp, M. Schmelling, B. Schmidt, O. Schneider, A. Schopper, M.-H. Schune, R. Schwemmer, B. Sciascia, A. Sciubba, M. Seco, A. Semennikov, K. Senderowska, I. Sepp, N. Serra, J. Serrano, L. Sestini, P. Seyfert, M. Shapkin, I. Shapoval, Y. Shcheglov, T. Shears, L. Shekhtman, V. Shevchenko, A. Shires, R. Silva Coutinho, G. Simi, M. Sirendi, N. Skidmore, T. Skwarnicki, N.A. Smith, E. Smith, J. Smith, M. Smith, H. Snoek, M.D. Sokoloff, F.J.P. Soler, F. Soomro, D. Souza, B. Souza De Paula, B. Spaan, A. Sparkes, P. Spradlin, F. Stagni, S. Stahl, O. Steinkamp, O. Stenyakin, S. Stevenson, S. Stoica, S. Stone, B. Storaci, S. Stracka, M. Straticiuc, U. Straumann, R. Stroili, V.K. Subbiah, L. Sun, W. Sutcliffe, K. Swientek, S. Swientek, V. Syropoulos, M. Szczekowski, P. Szczypka, D. Szilard, T. Szumlak, S. T'Jampens, M. Teklishyn, G. Tellarini, F. Teubert, C. Thomas, E. Thomas, J. van Tilburg, V. Tisserand, M. Tobin, S. Tolk, L. Tomassetti, D. Tonelli, S. Topp-Joergensen, N. Torr, E. Tournefier, S. Tourneur, M.T. Tran, M. Tresch, A. Tsaregorodtsev, P. Tsopelas, N. Tuning, M. Ubeda Garcia, A. Ukleja, A. Ustyuzhanin, U. Uwer, V. Vagnoni, G. Valenti, A. Vallier, R. Vazquez Gomez, P. Vazquez Regueiro, C. Vázquez Sierra, S. Vecchi, J.J. Velthuis, M. Veltri, G. Veneziano, M. Vesterinen, B. Viaud, D. Vieira, M. Vieites Diaz, X. Vilasis-Cardona, A. Vollhardt, D. Volyanskyy, D. Voong, A. Vorobyev, V. Vorobyev, C. Voß, H. Voss, J.A. de Vries, R. Waldi, C. Wallace, R. Wallace, J. Walsh, S. Wandernoth, J. Wang, D.R. Ward, N.K. Watson, D. Websdale, M. Whitehead, J. Wicht, D. Wiedner, G. Wilkinson, M.P. Williams, M. Williams, F.F. Wilson, J. Wimberley, J. Wishahi, W. Wislicki, M. Witek, G. Wormser, S.A. Wotton, S. Wright, S. Wu, K. Wyllie, Y. Xie, Z. Xing, Z. Xu, Z. Yang, X. Yuan, O. Yushchenko, M. Zangoli, M. Zavertyaev, F. Zhang, L. Zhang, W.C. Zhang, Y. Zhang, A. Zhelezov, A. Zhokhov, L. Zhong, and A. Zvyagin

Subjects
Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

A model-dependent amplitude analysis of B±→DK± with D→KS0π+π− decays is performed using proton–proton collision data, corresponding to an integrated luminosity of 1 fb−1, recorded by LHCb at a centre-of-mass energy of 7 TeV in 2011. Values of the CP violation observables x± and y±, which are sensitive to the CKM angle γ, are measured to be x−=+0.027±0.044−0.008+0.010±0.001, y−=+0.013±0.048−0.007+0.009±0.003, x+=−0.084±0.045±0.009±0.005, y+=−0.032±0.048−0.009+0.010±0.008, where the first uncertainty is statistical, the second systematic and the third arises from the uncertainty of the D→KS0π+π− amplitude model. The value of γ is determined to be (84−42+49)°, including all sources of uncertainty. Neutral D meson mixing is found to have negligible effect.

Published
2014
Full Text
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19. Effective lifetime measurements in the Bs0→K+K−, B0→K+π− and Bs0→π+K− decays

Author

R. Aaij, B. Adeva, M. Adinolfi, A. Affolder, Z. Ajaltouni, J. Albrecht, F. Alessio, M. Alexander, S. Ali, G. Alkhazov, P. Alvarez Cartelle, A.A. Alves, Jr., S. Amato, S. Amerio, Y. Amhis, L. An, L. Anderlini, J. Anderson, R. Andreassen, M. Andreotti, J.E. Andrews, R.B. Appleby, O. Aquines Gutierrez, F. Archilli, A. Artamonov, M. Artuso, E. Aslanides, G. Auriemma, M. Baalouch, S. Bachmann, J.J. Back, A. Badalov, V. Balagura, W. Baldini, R.J. Barlow, C. Barschel, S. Barsuk, W. Barter, V. Batozskaya, Th. Bauer, A. Bay, J. Beddow, F. Bedeschi, I. Bediaga, S. Belogurov, K. Belous, I. Belyaev, E. Ben-Haim, G. Bencivenni, S. Benson, J. Benton, A. Berezhnoy, R. Bernet, M.-O. Bettler, M. van Beuzekom, A. Bien, S. Bifani, T. Bird, A. Bizzeti, P.M. Bjørnstad, T. Blake, F. Blanc, J. Blouw, S. Blusk, V. Bocci, A. Bondar, N. Bondar, W. Bonivento, S. Borghi, A. Borgia, M. Borsato, T.J.V. Bowcock, E. Bowen, C. Bozzi, T. Brambach, J. van den Brand, J. Bressieux, D. Brett, M. Britsch, T. Britton, N.H. Brook, H. Brown, A. Bursche, G. Busetto, J. Buytaert, S. Cadeddu, R. Calabrese, M. Calvi, M. Calvo Gomez, A. Camboni, P. Campana, D. Campora Perez, A. Carbone, G. Carboni, R. Cardinale, A. Cardini, H. Carranza-Mejia, L. Carson, K. Carvalho Akiba, G. Casse, L. Cassina, L. Castillo Garcia, M. Cattaneo, Ch. Cauet, R. Cenci, M. Charles, Ph. Charpentier, S.-F. Cheung, N. Chiapolini, M. Chrzaszcz, K. Ciba, X. Cid Vidal, G. Ciezarek, P.E.L. Clarke, M. Clemencic, H.V. Cliff, J. Closier, V. Coco, J. Cogan, E. Cogneras, P. Collins, A. Comerma-Montells, A. Contu, A. Cook, M. Coombes, S. Coquereau, G. Corti, M. Corvo, I. Counts, B. Couturier, G.A. Cowan, D.C. Craik, M. Cruz Torres, S. Cunliffe, R. Currie, C. D'Ambrosio, J. Dalseno, P. David, P.N.Y. David, A. Davis, K. De Bruyn, S. De Capua, M. De Cian, J.M. De Miranda, L. De Paula, W. De Silva, P. De Simone, D. Decamp, M. Deckenhoff, L. Del Buono, N. Déléage, D. Derkach, O. Deschamps, F. Dettori, A. Di Canto, H. Dijkstra, S. Donleavy, F. Dordei, M. Dorigo, A. Dosil Suárez, D. Dossett, A. Dovbnya, F. Dupertuis, P. Durante, R. Dzhelyadin, A. Dziurda, A. Dzyuba, S. Easo, U. Egede, V. Egorychev, S. Eidelman, S. Eisenhardt, U. Eitschberger, R. Ekelhof, L. Eklund, I. El Rifai, Ch. Elsasser, S. Esen, A. Falabella, C. Färber, C. Farinelli, N. Farley, S. Farry, R.F. Fay, D. Ferguson, V. Fernandez Albor, F. Ferreira Rodrigues, M. Ferro-Luzzi, S. Filippov, M. Fiore, M. Fiorini, M. Firlej, C. Fitzpatrick, T. Fiutowski, M. Fontana, F. Fontanelli, R. Forty, O. Francisco, M. Frank, C. Frei, M. Frosini, J. Fu, E. Furfaro, A. Gallas Torreira, D. Galli, S. Gallorini, S. Gambetta, M. Gandelman, P. Gandini, Y. Gao, J. Garofoli, J. Garra Tico, L. Garrido, C. Gaspar, R. Gauld, L. Gavardi, A. Geraci, E. Gersabeck, M. Gersabeck, T. Gershon, Ph. Ghez, A. Gianelle, S. Giani', V. Gibson, L. Giubega, V.V. Gligorov, C. Göbel, D. Golubkov, A. Golutvin, A. Gomes, H. Gordon, C. Gotti, M. Grabalosa Gándara, R. Graciani Diaz, L.A. Granado Cardoso, E. Graugés, G. Graziani, A. Grecu, E. Greening, S. Gregson, P. Griffith, L. Grillo, O. Grünberg, B. Gui, E. Gushchin, Yu. Guz, T. Gys, C. Hadjivasiliou, G. Haefeli, C. Haen, S.C. Haines, S. Hall, B. Hamilton, T. Hampson, X. Han, S. Hansmann-Menzemer, N. Harnew, S.T. Harnew, J. Harrison, T. Hartmann, J. He, T. Head, V. Heijne, K. Hennessy, P. Henrard, L. Henry, J.A. Hernando Morata, E. van Herwijnen, M. Heß, A. Hicheur, D. Hill, M. Hoballah, C. Hombach, W. Hulsbergen, P. Hunt, N. Hussain, D. Hutchcroft, D. Hynds, M. Idzik, P. Ilten, R. Jacobsson, A. Jaeger, J. Jalocha, E. Jans, P. Jaton, A. Jawahery, F. Jing, M. John, D. Johnson, C.R. Jones, C. Joram, B. Jost, N. Jurik, M. Kaballo, S. Kandybei, W. Kanso, M. Karacson, T.M. Karbach, M. Kelsey, I.R. Kenyon, T. Ketel, B. Khanji, C. Khurewathanakul, S. Klaver, O. Kochebina, M. Kolpin, I. Komarov, R.F. Koopman, P. Koppenburg, M. Korolev, A. Kozlinskiy, L. Kravchuk, K. Kreplin, M. Kreps, G. Krocker, P. Krokovny, F. Kruse, M. Kucharczyk, V. Kudryavtsev, K. Kurek, T. Kvaratskheliya, V.N. La Thi, D. Lacarrere, G. Lafferty, A. Lai, D. Lambert, R.W. Lambert, E. Lanciotti, G. Lanfranchi, C. Langenbruch, B. Langhans, T. Latham, C. Lazzeroni, R. Le Gac, J. van Leerdam, J.-P. Lees, R. Lefèvre, A. Leflat, J. Lefrançois, S. Leo, O. Leroy, T. Lesiak, B. Leverington, Y. Li, M. Liles, R. Lindner, C. Linn, F. Lionetto, B. Liu, G. Liu, S. Lohn, I. Longstaff, J.H. Lopes, N. Lopez-March, P. Lowdon, H. Lu, D. Lucchesi, H. Luo, A. Lupato, E. Luppi, O. Lupton, F. Machefert, I.V. Machikhiliyan, F. Maciuc, O. Maev, S. Malde, G. Manca, G. Mancinelli, A. Mapelli, J. Maratas, J.F. Marchand, U. Marconi, C. Marin Benito, P. Marino, R. Märki, J. Marks, G. Martellotti, A. Martens, A. Martín Sánchez, M. Martinelli, D. Martinez Santos, F. Martinez Vidal, D. Martins Tostes, A. Massafferri, R. Matev, Z. Mathe, C. Matteuzzi, A. Mazurov, M. McCann, J. McCarthy, A. McNab, R. McNulty, B. McSkelly, B. Meadows, F. Meier, M. Meissner, M. Merk, D.A. Milanes, M.-N. Minard, N. Moggi, J. Molina Rodriguez, S. Monteil, D. Moran, M. Morandin, P. Morawski, A. Mordà, M.J. Morello, J. Moron, R. Mountain, F. Muheim, K. Müller, R. Muresan, M. Mussini, B. Muster, P. Naik, T. Nakada, R. Nandakumar, I. Nasteva, M. Needham, N. Neri, S. Neubert, N. Neufeld, M. Neuner, A.D. Nguyen, T.D. Nguyen, C. Nguyen-Mau, M. Nicol, V. Niess, R. Niet, N. Nikitin, T. Nikodem, A. Novoselov, A. Oblakowska-Mucha, V. Obraztsov, S. Oggero, S. Ogilvy, O. Okhrimenko, R. Oldeman, G. Onderwater, M. Orlandea, J.M. Otalora Goicochea, P. Owen, A. Oyanguren, B.K. Pal, A. Palano, F. Palombo, M. Palutan, J. Panman, A. Papanestis, M. Pappagallo, C. Parkes, C.J. Parkinson, G. Passaleva, G.D. Patel, M. Patel, C. Patrignani, A. Pazos Alvarez, A. Pearce, A. Pellegrino, M. Pepe Altarelli, S. Perazzini, E. Perez Trigo, P. Perret, M. Perrin-Terrin, L. Pescatore, E. Pesen, K. Petridis, A. Petrolini, E. Picatoste Olloqui, B. Pietrzyk, T. Pilař, D. Pinci, A. Pistone, S. Playfer, M. Plo Casasus, F. Polci, A. Poluektov, E. Polycarpo, A. Popov, D. Popov, B. Popovici, C. Potterat, A. Powell, J. Prisciandaro, A. Pritchard, C. Prouve, V. Pugatch, A. Puig Navarro, G. Punzi, W. Qian, B. Rachwal, J.H. Rademacker, B. Rakotomiaramanana, M. Rama, M.S. Rangel, I. Raniuk, N. Rauschmayr, G. Raven, S. Reichert, M.M. Reid, A.C. dos Reis, S. Ricciardi, A. Richards, M. Rihl, K. Rinnert, V. Rives Molina, D.A. Roa Romero, P. Robbe, A.B. Rodrigues, E. Rodrigues, P. Rodriguez Perez, S. Roiser, V. Romanovsky, A. Romero Vidal, M. Rotondo, J. Rouvinet, T. Ruf, F. Ruffini, H. Ruiz, P. Ruiz Valls, G. Sabatino, J.J. Saborido Silva, N. Sagidova, P. Sail, B. Saitta, V. Salustino Guimaraes, C. Sanchez Mayordomo, B. Sanmartin Sedes, R. Santacesaria, C. Santamarina Rios, E. Santovetti, M. Sapunov, A. Sarti, C. Satriano, A. Satta, M. Savrie, D. Savrina, M. Schiller, H. Schindler, M. Schlupp, M. Schmelling, B. Schmidt, O. Schneider, A. Schopper, M.-H. Schune, R. Schwemmer, B. Sciascia, A. Sciubba, M. Seco, A. Semennikov, K. Senderowska, I. Sepp, N. Serra, J. Serrano, L. Sestini, P. Seyfert, M. Shapkin, I. Shapoval, Y. Shcheglov, T. Shears, L. Shekhtman, V. Shevchenko, A. Shires, R. Silva Coutinho, G. Simi, M. Sirendi, N. Skidmore, T. Skwarnicki, N.A. Smith, E. Smith, J. Smith, M. Smith, H. Snoek, M.D. Sokoloff, F.J.P. Soler, F. Soomro, D. Souza, B. Souza De Paula, B. Spaan, A. Sparkes, P. Spradlin, F. Stagni, S. Stahl, O. Steinkamp, O. Stenyakin, S. Stevenson, S. Stoica, S. Stone, B. Storaci, S. Stracka, M. Straticiuc, U. Straumann, R. Stroili, V.K. Subbiah, L. Sun, W. Sutcliffe, K. Swientek, S. Swientek, V. Syropoulos, M. Szczekowski, P. Szczypka, D. Szilard, T. Szumlak, S. T'Jampens, M. Teklishyn, G. Tellarini, F. Teubert, C. Thomas, E. Thomas, J. van Tilburg, V. Tisserand, M. Tobin, S. Tolk, L. Tomassetti, D. Tonelli, S. Topp-Joergensen, N. Torr, E. Tournefier, S. Tourneur, M.T. Tran, M. Tresch, A. Tsaregorodtsev, P. Tsopelas, N. Tuning, M. Ubeda Garcia, A. Ukleja, A. Ustyuzhanin, U. Uwer, V. Vagnoni, G. Valenti, A. Vallier, R. Vazquez Gomez, P. Vazquez Regueiro, C. Vázquez Sierra, S. Vecchi, J.J. Velthuis, M. Veltri, G. Veneziano, M. Vesterinen, B. Viaud, D. Vieira, M. Vieites Diaz, X. Vilasis-Cardona, A. Vollhardt, D. Volyanskyy, D. Voong, A. Vorobyev, V. Vorobyev, C. Voß, H. Voss, J.A. de Vries, R. Waldi, C. Wallace, R. Wallace, J. Walsh, S. Wandernoth, J. Wang, D.R. Ward, N.K. Watson, D. Websdale, M. Whitehead, J. Wicht, D. Wiedner, G. Wilkinson, M.P. Williams, M. Williams, F.F. Wilson, J. Wimberley, J. Wishahi, W. Wislicki, M. Witek, G. Wormser, S.A. Wotton, S. Wright, S. Wu, K. Wyllie, Y. Xie, Z. Xing, Z. Xu, Z. Yang, X. Yuan, O. Yushchenko, M. Zangoli, M. Zavertyaev, F. Zhang, L. Zhang, W.C. Zhang, Y. Zhang, A. Zhelezov, A. Zhokhov, L. Zhong, and A. Zvyagin

Subjects
Physics, QC1-999
Abstract

Measurements of the effective lifetimes in the Bs0→K+K−, B0→K+π− and Bs0→π+K− decays are presented using 1.0 fb−1 of pp collision data collected at a centre-of-mass energy of 7 TeV by the LHCb experiment. The analysis uses a data-driven approach to correct for the decay time acceptance. The measured effective lifetimes are τBs0→K+K−=1.407±0.016(stat)±0.007(syst) ps, τB0→K+π−=1.524±0.011(stat)±0.004(syst) ps, τBs0→π+K−=1.60±0.06(stat)±0.01(syst) ps. This is the most precise determination to date of the effective lifetime in the Bs0→K+K− decay and provides constraints on contributions from physics beyond the Standard Model to the Bs0 mixing phase and the width difference ΔΓs.

Published
2014
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20. Evidence for the decay X(3872)→ψ(2S)γ

Author

R. Aaij, B. Adeva, M. Adinolfi, A. Affolder, Z. Ajaltouni, J. Albrecht, F. Alessio, M. Alexander, S. Ali, G. Alkhazov, P. Alvarez Cartelle, A.A. Alves, Jr., S. Amato, S. Amerio, Y. Amhis, L. An, L. Anderlini, J. Anderson, R. Andreassen, M. Andreotti, J.E. Andrews, R.B. Appleby, O. Aquines Gutierrez, F. Archilli, A. Artamonov, M. Artuso, E. Aslanides, G. Auriemma, M. Baalouch, S. Bachmann, J.J. Back, A. Badalov, V. Balagura, W. Baldini, R.J. Barlow, C. Barschel, S. Barsuk, W. Barter, V. Batozskaya, Th. Bauer, A. Bay, J. Beddow, F. Bedeschi, I. Bediaga, S. Belogurov, K. Belous, I. Belyaev, E. Ben-Haim, G. Bencivenni, S. Benson, J. Benton, A. Berezhnoy, R. Bernet, M.-O. Bettler, M. van Beuzekom, A. Bien, S. Bifani, T. Bird, A. Bizzeti, P.M. Bjørnstad, T. Blake, F. Blanc, J. Blouw, S. Blusk, V. Bocci, A. Bondar, N. Bondar, W. Bonivento, S. Borghi, A. Borgia, M. Borsato, T.J.V. Bowcock, E. Bowen, C. Bozzi, T. Brambach, J. van den Brand, J. Bressieux, D. Brett, M. Britsch, T. Britton, N.H. Brook, H. Brown, A. Bursche, G. Busetto, J. Buytaert, S. Cadeddu, R. Calabrese, O. Callot, M. Calvi, M. Calvo Gomez, A. Camboni, P. Campana, D. Campora Perez, A. Carbone, G. Carboni, R. Cardinale, A. Cardini, H. Carranza-Mejia, L. Carson, K. Carvalho Akiba, G. Casse, L. Cassina, L. Castillo Garcia, M. Cattaneo, Ch. Cauet, R. Cenci, M. Charles, Ph. Charpentier, S.-F. Cheung, N. Chiapolini, M. Chrzaszcz, K. Ciba, X. Cid Vidal, G. Ciezarek, P.E.L. Clarke, M. Clemencic, H.V. Cliff, J. Closier, C. Coca, V. Coco, J. Cogan, E. Cogneras, P. Collins, A. Comerma-Montells, A. Contu, A. Cook, M. Coombes, S. Coquereau, G. Corti, M. Corvo, I. Counts, B. Couturier, G.A. Cowan, D.C. Craik, M. Cruz Torres, S. Cunliffe, R. Currie, C. D'Ambrosio, J. Dalseno, P. David, P.N.Y. David, A. Davis, K. De Bruyn, S. De Capua, M. De Cian, J.M. De Miranda, L. De Paula, W. De Silva, P. De Simone, D. Decamp, M. Deckenhoff, L. Del Buono, N. Déléage, D. Derkach, O. Deschamps, F. Dettori, A. Di Canto, H. Dijkstra, S. Donleavy, F. Dordei, M. Dorigo, A. Dosil Suárez, D. Dossett, A. Dovbnya, F. Dupertuis, P. Durante, R. Dzhelyadin, A. Dziurda, A. Dzyuba, S. Easo, U. Egede, V. Egorychev, S. Eidelman, S. Eisenhardt, U. Eitschberger, R. Ekelhof, L. Eklund, I. El Rifai, Ch. Elsasser, S. Esen, T. Evans, A. Falabella, C. Färber, C. Farinelli, S. Farry, D. Ferguson, V. Fernandez Albor, F. Ferreira Rodrigues, M. Ferro-Luzzi, S. Filippov, M. Fiore, M. Fiorini, M. Firlej, C. Fitzpatrick, T. Fiutowski, M. Fontana, F. Fontanelli, R. Forty, O. Francisco, M. Frank, C. Frei, M. Frosini, J. Fu, E. Furfaro, A. Gallas Torreira, D. Galli, S. Gallorini, S. Gambetta, M. Gandelman, P. Gandini, Y. Gao, J. Garofoli, J. Garra Tico, L. Garrido, C. Gaspar, R. Gauld, L. Gavardi, E. Gersabeck, M. Gersabeck, T. Gershon, Ph. Ghez, A. Gianelle, S. Giani', V. Gibson, L. Giubega, V.V. Gligorov, C. Göbel, D. Golubkov, A. Golutvin, A. Gomes, H. Gordon, C. Gotti, M. Grabalosa Gándara, R. Graciani Diaz, L.A. Granado Cardoso, E. Graugés, G. Graziani, A. Grecu, E. Greening, S. Gregson, P. Griffith, L. Grillo, O. Grünberg, B. Gui, E. Gushchin, Yu. Guz, T. Gys, C. Hadjivasiliou, G. Haefeli, C. Haen, S.C. Haines, S. Hall, B. Hamilton, T. Hampson, X. Han, S. Hansmann-Menzemer, N. Harnew, S.T. Harnew, J. Harrison, T. Hartmann, J. He, T. Head, V. Heijne, K. Hennessy, P. Henrard, L. Henry, J.A. Hernando Morata, E. van Herwijnen, M. Heß, A. Hicheur, D. Hill, M. Hoballah, C. Hombach, W. Hulsbergen, P. Hunt, N. Hussain, D. Hutchcroft, D. Hynds, M. Idzik, P. Ilten, R. Jacobsson, A. Jaeger, J. Jalocha, E. Jans, P. Jaton, A. Jawahery, M. Jezabek, F. Jing, M. John, D. Johnson, C.R. Jones, C. Joram, B. Jost, N. Jurik, M. Kaballo, S. Kandybei, W. Kanso, M. Karacson, T.M. Karbach, M. Kelsey, I.R. Kenyon, T. Ketel, B. Khanji, C. Khurewathanakul, S. Klaver, O. Kochebina, M. Kolpin, I. Komarov, R.F. Koopman, P. Koppenburg, M. Korolev, A. Kozlinskiy, L. Kravchuk, K. Kreplin, M. Kreps, G. Krocker, P. Krokovny, F. Kruse, M. Kucharczyk, V. Kudryavtsev, K. Kurek, T. Kvaratskheliya, V.N. La Thi, D. Lacarrere, G. Lafferty, A. Lai, D. Lambert, R.W. Lambert, E. Lanciotti, G. Lanfranchi, C. Langenbruch, B. Langhans, T. Latham, C. Lazzeroni, R. Le Gac, J. van Leerdam, J.-P. Lees, R. Lefèvre, A. Leflat, J. Lefrançois, S. Leo, O. Leroy, T. Lesiak, B. Leverington, Y. Li, M. Liles, R. Lindner, C. Linn, F. Lionetto, B. Liu, G. Liu, S. Lohn, I. Longstaff, J.H. Lopes, N. Lopez-March, P. Lowdon, H. Lu, D. Lucchesi, H. Luo, A. Lupato, E. Luppi, O. Lupton, F. Machefert, I.V. Machikhiliyan, F. Maciuc, O. Maev, S. Malde, G. Manca, G. Mancinelli, M. Manzali, J. Maratas, J.F. Marchand, U. Marconi, C. Marin Benito, P. Marino, R. Märki, J. Marks, G. Martellotti, A. Martens, A. Martín Sánchez, M. Martinelli, D. Martinez Santos, F. Martinez Vidal, D. Martins Tostes, A. Massafferri, R. Matev, Z. Mathe, C. Matteuzzi, A. Mazurov, M. McCann, J. McCarthy, A. McNab, R. McNulty, B. McSkelly, B. Meadows, F. Meier, M. Meissner, M. Merk, D.A. Milanes, M.-N. Minard, J. Molina Rodriguez, S. Monteil, D. Moran, M. Morandin, P. Morawski, A. Mordà, M.J. Morello, J. Moron, R. Mountain, F. Muheim, K. Müller, R. Muresan, B. Muster, P. Naik, T. Nakada, R. Nandakumar, I. Nasteva, M. Needham, N. Neri, S. Neubert, N. Neufeld, M. Neuner, A.D. Nguyen, T.D. Nguyen, C. Nguyen-Mau, M. Nicol, V. Niess, R. Niet, N. Nikitin, T. Nikodem, A. Novoselov, A. Oblakowska-Mucha, V. Obraztsov, S. Oggero, S. Ogilvy, O. Okhrimenko, R. Oldeman, G. Onderwater, M. Orlandea, J.M. Otalora Goicochea, P. Owen, A. Oyanguren, B.K. Pal, A. Palano, F. Palombo, M. Palutan, J. Panman, A. Papanestis, M. Pappagallo, C. Parkes, C.J. Parkinson, G. Passaleva, G.D. Patel, M. Patel, C. Patrignani, A. Pazos Alvarez, A. Pearce, A. Pellegrino, M. Pepe Altarelli, S. Perazzini, E. Perez Trigo, P. Perret, M. Perrin-Terrin, L. Pescatore, E. Pesen, K. Petridis, A. Petrolini, E. Picatoste Olloqui, B. Pietrzyk, T. Pilař, D. Pinci, A. Pistone, S. Playfer, M. Plo Casasus, F. Polci, A. Poluektov, I. Polyakov, E. Polycarpo, A. Popov, D. Popov, B. Popovici, C. Potterat, A. Powell, J. Prisciandaro, A. Pritchard, C. Prouve, V. Pugatch, A. Puig Navarro, G. Punzi, W. Qian, B. Rachwal, J.H. Rademacker, B. Rakotomiaramanana, M. Rama, M.S. Rangel, I. Raniuk, N. Rauschmayr, G. Raven, S. Reichert, M.M. Reid, A.C. dos Reis, S. Ricciardi, A. Richards, K. Rinnert, V. Rives Molina, D.A. Roa Romero, P. Robbe, A.B. Rodrigues, E. Rodrigues, P. Rodriguez Perez, S. Roiser, V. Romanovsky, A. Romero Vidal, M. Rotondo, J. Rouvinet, T. Ruf, F. Ruffini, H. Ruiz, P. Ruiz Valls, G. Sabatino, J.J. Saborido Silva, N. Sagidova, P. Sail, B. Saitta, V. Salustino Guimaraes, C. Sanchez Mayordomo, B. Sanmartin Sedes, R. Santacesaria, C. Santamarina Rios, E. Santovetti, M. Sapunov, A. Sarti, C. Satriano, A. Satta, M. Savrie, D. Savrina, M. Schiller, H. Schindler, M. Schlupp, M. Schmelling, B. Schmidt, O. Schneider, A. Schopper, M.-H. Schune, R. Schwemmer, B. Sciascia, A. Sciubba, M. Seco, A. Semennikov, K. Senderowska, I. Sepp, N. Serra, J. Serrano, L. Sestini, P. Seyfert, M. Shapkin, I. Shapoval, Y. Shcheglov, T. Shears, L. Shekhtman, V. Shevchenko, A. Shires, R. Silva Coutinho, G. Simi, M. Sirendi, N. Skidmore, T. Skwarnicki, N.A. Smith, E. Smith, J. Smith, M. Smith, H. Snoek, M.D. Sokoloff, F.J.P. Soler, F. Soomro, D. Souza, B. Souza De Paula, B. Spaan, A. Sparkes, F. Spinella, P. Spradlin, F. Stagni, S. Stahl, O. Steinkamp, O. Stenyakin, S. Stevenson, S. Stoica, S. Stone, B. Storaci, S. Stracka, M. Straticiuc, U. Straumann, R. Stroili, V.K. Subbiah, L. Sun, W. Sutcliffe, K. Swientek, S. Swientek, V. Syropoulos, M. Szczekowski, P. Szczypka, D. Szilard, T. Szumlak, S. T'Jampens, M. Teklishyn, G. Tellarini, E. Teodorescu, F. Teubert, C. Thomas, E. Thomas, J. van Tilburg, V. Tisserand, M. Tobin, S. Tolk, L. Tomassetti, D. Tonelli, S. Topp-Joergensen, N. Torr, E. Tournefier, S. Tourneur, M.T. Tran, M. Tresch, A. Tsaregorodtsev, P. Tsopelas, N. Tuning, M. Ubeda Garcia, A. Ukleja, A. Ustyuzhanin, U. Uwer, V. Vagnoni, G. Valenti, A. Vallier, R. Vazquez Gomez, P. Vazquez Regueiro, C. Vázquez Sierra, S. Vecchi, J.J. Velthuis, M. Veltri, G. Veneziano, M. Vesterinen, B. Viaud, D. Vieira, M. Vieites Diaz, X. Vilasis-Cardona, A. Vollhardt, D. Volyanskyy, D. Voong, A. Vorobyev, V. Vorobyev, C. Voß, H. Voss, J.A. de Vries, R. Waldi, C. Wallace, R. Wallace, J. Walsh, S. Wandernoth, J. Wang, D.R. Ward, N.K. Watson, A.D. Webber, D. Websdale, M. Whitehead, J. Wicht, D. Wiedner, G. Wilkinson, M.P. Williams, M. Williams, F.F. Wilson, J. Wimberley, J. Wishahi, W. Wislicki, M. Witek, G. Wormser, S.A. Wotton, S. Wright, S. Wu, K. Wyllie, Y. Xie, Z. Xing, Z. Xu, Z. Yang, X. Yuan, O. Yushchenko, M. Zangoli, M. Zavertyaev, F. Zhang, L. Zhang, W.C. Zhang, Y. Zhang, A. Zhelezov, A. Zhokhov, L. Zhong, and A. Zvyagin

Subjects
Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Evidence for the decay mode X(3872)→ψ(2S)γ in B+→X(3872)K+ decays is found with a significance of 4.4 standard deviations. The analysis is based on a data sample of proton–proton collisions, corresponding to an integrated luminosity of 3 fb−1, collected with the LHCb detector, at centre-of-mass energies of 7 and 8 TeV. The ratio of the branching fraction of the X(3872)→ψ(2S)γ decay to that of the X(3872)→J/ψγ decay is measured to be B(X(3872)→ψ(2S)γ)B(X(3872)→J/ψγ)=2.46±0.64±0.29, where the first uncertainty is statistical and the second is systematic. The measured value does not support a pure DD¯⁎ molecular interpretation of the X(3872) state.

Published
2014
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21. Measurement of the Ξb− and Ωb− baryon lifetimes

Author

R. Aaij, B. Adeva, M. Adinolfi, A. Affolder, Z. Ajaltouni, J. Albrecht, F. Alessio, M. Alexander, S. Ali, G. Alkhazov, P. Alvarez Cartelle, A.A. Alves, Jr, S. Amato, S. Amerio, Y. Amhis, L. An, L. Anderlini, J. Anderson, R. Andreassen, M. Andreotti, J.E. Andrews, R.B. Appleby, O. Aquines Gutierrez, F. Archilli, A. Artamonov, M. Artuso, E. Aslanides, G. Auriemma, M. Baalouch, S. Bachmann, J.J. Back, A. Badalov, V. Balagura, W. Baldini, R.J. Barlow, C. Barschel, S. Barsuk, W. Barter, V. Batozskaya, Th. Bauer, A. Bay, J. Beddow, F. Bedeschi, I. Bediaga, S. Belogurov, K. Belous, I. Belyaev, E. Ben-Haim, G. Bencivenni, S. Benson, J. Benton, A. Berezhnoy, R. Bernet, M.-O. Bettler, M. van Beuzekom, A. Bien, S. Bifani, T. Bird, A. Bizzeti, P.M. Bjørnstad, T. Blake, F. Blanc, J. Blouw, S. Blusk, V. Bocci, A. Bondar, N. Bondar, W. Bonivento, S. Borghi, A. Borgia, M. Borsato, T.J.V. Bowcock, E. Bowen, C. Bozzi, T. Brambach, J. van den Brand, J. Bressieux, D. Brett, M. Britsch, T. Britton, N.H. Brook, H. Brown, A. Bursche, G. Busetto, J. Buytaert, S. Cadeddu, R. Calabrese, M. Calvi, M. Calvo Gomez, A. Camboni, P. Campana, D. Campora Perez, A. Carbone, G. Carboni, R. Cardinale, A. Cardini, H. Carranza-Mejia, L. Carson, K. Carvalho Akiba, G. Casse, L. Cassina, L. Castillo Garcia, M. Cattaneo, Ch. Cauet, R. Cenci, M. Charles, Ph. Charpentier, S.-F. Cheung, N. Chiapolini, M. Chrzaszcz, K. Ciba, X. Cid Vidal, G. Ciezarek, P.E.L. Clarke, M. Clemencic, H.V. Cliff, J. Closier, V. Coco, J. Cogan, E. Cogneras, P. Collins, A. Comerma-Montells, A. Contu, A. Cook, M. Coombes, S. Coquereau, G. Corti, M. Corvo, I. Counts, B. Couturier, G.A. Cowan, D.C. Craik, M. Cruz Torres, S. Cunliffe, R. Currie, C. D'Ambrosio, J. Dalseno, P. David, P.N.Y. David, A. Davis, K. De Bruyn, S. De Capua, M. De Cian, J.M. De Miranda, L. De Paula, W. De Silva, P. De Simone, D. Decamp, M. Deckenhoff, L. Del Buono, N. Déléage, D. Derkach, O. Deschamps, F. Dettori, A. Di Canto, H. Dijkstra, S. Donleavy, F. Dordei, M. Dorigo, A. Dosil Suárez, D. Dossett, A. Dovbnya, F. Dupertuis, P. Durante, R. Dzhelyadin, A. Dziurda, A. Dzyuba, S. Easo, U. Egede, V. Egorychev, S. Eidelman, S. Eisenhardt, U. Eitschberger, R. Ekelhof, L. Eklund, I. El Rifai, Ch. Elsasser, S. Esen, T. Evans, A. Falabella, C. Färber, C. Farinelli, N. Farley, S. Farry, D. Ferguson, V. Fernandez Albor, F. Ferreira Rodrigues, M. Ferro-Luzzi, S. Filippov, M. Fiore, M. Fiorini, M. Firlej, C. Fitzpatrick, T. Fiutowski, M. Fontana, F. Fontanelli, R. Forty, O. Francisco, M. Frank, C. Frei, M. Frosini, J. Fu, E. Furfaro, A. Gallas Torreira, D. Galli, S. Gallorini, S. Gambetta, M. Gandelman, P. Gandini, Y. Gao, J. Garofoli, J. Garra Tico, L. Garrido, C. Gaspar, R. Gauld, L. Gavardi, E. Gersabeck, M. Gersabeck, T. Gershon, Ph. Ghez, A. Gianelle, S. Gianì, V. Gibson, L. Giubega, V.V. Gligorov, C. Göbel, D. Golubkov, A. Golutvin, A. Gomes, H. Gordon, C. Gotti, M. Grabalosa Gándara, R. Graciani Diaz, L.A. Granado Cardoso, E. Graugés, G. Graziani, A. Grecu, E. Greening, S. Gregson, P. Griffith, L. Grillo, O. Grünberg, B. Gui, E. Gushchin, Yu. Guz, T. Gys, C. Hadjivasiliou, G. Haefeli, C. Haen, S.C. Haines, S. Hall, B. Hamilton, T. Hampson, X. Han, S. Hansmann-Menzemer, N. Harnew, S.T. Harnew, J. Harrison, T. Hartmann, J. He, T. Head, V. Heijne, K. Hennessy, P. Henrard, L. Henry, J.A. Hernando Morata, E. van Herwijnen, M. Heß, A. Hicheur, D. Hill, M. Hoballah, C. Hombach, W. Hulsbergen, P. Hunt, N. Hussain, D. Hutchcroft, D. Hynds, M. Idzik, P. Ilten, R. Jacobsson, A. Jaeger, J. Jalocha, E. Jans, P. Jaton, A. Jawahery, M. Jezabek, F. Jing, M. John, D. Johnson, C.R. Jones, C. Joram, B. Jost, N. Jurik, M. Kaballo, S. Kandybei, W. Kanso, M. Karacson, T.M. Karbach, M. Kelsey, I.R. Kenyon, T. Ketel, B. Khanji, C. Khurewathanakul, S. Klaver, O. Kochebina, M. Kolpin, I. Komarov, R.F. Koopman, P. Koppenburg, M. Korolev, A. Kozlinskiy, L. Kravchuk, K. Kreplin, M. Kreps, G. Krocker, P. Krokovny, F. Kruse, M. Kucharczyk, V. Kudryavtsev, K. Kurek, T. Kvaratskheliya, V.N. La Thi, D. Lacarrere, G. Lafferty, A. Lai, D. Lambert, R.W. Lambert, E. Lanciotti, G. Lanfranchi, C. Langenbruch, B. Langhans, T. Latham, C. Lazzeroni, R. Le Gac, J. van Leerdam, J.-P. Lees, R. Lefèvre, A. Leflat, J. Lefrançois, S. Leo, O. Leroy, T. Lesiak, B. Leverington, Y. Li, M. Liles, R. Lindner, C. Linn, F. Lionetto, B. Liu, G. Liu, S. Lohn, I. Longstaff, J.H. Lopes, N. Lopez-March, P. Lowdon, H. Lu, D. Lucchesi, H. Luo, A. Lupato, E. Luppi, O. Lupton, F. Machefert, I.V. Machikhiliyan, F. Maciuc, O. Maev, S. Malde, G. Manca, G. Mancinelli, M. Manzali, J. Maratas, J.F. Marchand, U. Marconi, C. Marin Benito, P. Marino, R. Märki, J. Marks, G. Martellotti, A. Martens, A. Martín Sánchez, M. Martinelli, D. Martinez Santos, F. Martinez Vidal, D. Martins Tostes, A. Massafferri, R. Matev, Z. Mathe, C. Matteuzzi, A. Mazurov, M. McCann, J. McCarthy, A. McNab, R. McNulty, B. McSkelly, B. Meadows, F. Meier, M. Meissner, M. Merk, D.A. Milanes, M.-N. Minard, N. Moggi, J. Molina Rodriguez, S. Monteil, D. Moran, M. Morandin, P. Morawski, A. Mordà, M.J. Morello, J. Moron, R. Mountain, F. Muheim, K. Müller, R. Muresan, M. Mussini, B. Muster, P. Naik, T. Nakada, R. Nandakumar, I. Nasteva, M. Needham, N. Neri, S. Neubert, N. Neufeld, M. Neuner, A.D. Nguyen, T.D. Nguyen, C. Nguyen-Mau, M. Nicol, V. Niess, R. Niet, N. Nikitin, T. Nikodem, A. Novoselov, A. Oblakowska-Mucha, V. Obraztsov, S. Oggero, S. Ogilvy, O. Okhrimenko, R. Oldeman, G. Onderwater, M. Orlandea, J.M. Otalora Goicochea, P. Owen, A. Oyanguren, B.K. Pal, A. Palano, F. Palombo, M. Palutan, J. Panman, A. Papanestis, M. Pappagallo, C. Parkes, C.J. Parkinson, G. Passaleva, G.D. Patel, M. Patel, C. Patrignani, A. Pazos Alvarez, A. Pearce, A. Pellegrino, M. Pepe Altarelli, S. Perazzini, E. Perez Trigo, P. Perret, M. Perrin-Terrin, L. Pescatore, E. Pesen, K. Petridis, A. Petrolini, E. Picatoste Olloqui, B. Pietrzyk, T. Pilař, D. Pinci, A. Pistone, S. Playfer, M. Plo Casasus, F. Polci, A. Poluektov, E. Polycarpo, A. Popov, D. Popov, B. Popovici, C. Potterat, A. Powell, J. Prisciandaro, A. Pritchard, C. Prouve, V. Pugatch, A. Puig Navarro, G. Punzi, W. Qian, B. Rachwal, J.H. Rademacker, B. Rakotomiaramanana, M. Rama, M.S. Rangel, I. Raniuk, N. Rauschmayr, G. Raven, S. Reichert, M.M. Reid, A.C. dos Reis, S. Ricciardi, A. Richards, M. Rihl, K. Rinnert, V. Rives Molina, D.A. Roa Romero, P. Robbe, A.B. Rodrigues, E. Rodrigues, P. Rodriguez Perez, S. Roiser, V. Romanovsky, A. Romero Vidal, M. Rotondo, J. Rouvinet, T. Ruf, F. Ruffini, H. Ruiz, P. Ruiz Valls, G. Sabatino, J.J. Saborido Silva, N. Sagidova, P. Sail, B. Saitta, V. Salustino Guimaraes, C. Sanchez Mayordomo, B. Sanmartin Sedes, R. Santacesaria, C. Santamarina Rios, E. Santovetti, M. Sapunov, A. Sarti, C. Satriano, A. Satta, M. Savrie, D. Savrina, M. Schiller, H. Schindler, M. Schlupp, M. Schmelling, B. Schmidt, O. Schneider, A. Schopper, M.-H. Schune, R. Schwemmer, B. Sciascia, A. Sciubba, M. Seco, A. Semennikov, K. Senderowska, I. Sepp, N. Serra, J. Serrano, L. Sestini, P. Seyfert, M. Shapkin, I. Shapoval, Y. Shcheglov, T. Shears, L. Shekhtman, V. Shevchenko, A. Shires, R. Silva Coutinho, G. Simi, M. Sirendi, N. Skidmore, T. Skwarnicki, N.A. Smith, E. Smith, J. Smith, M. Smith, H. Snoek, M.D. Sokoloff, F.J.P. Soler, F. Soomro, D. Souza, B. Souza De Paula, B. Spaan, A. Sparkes, F. Spinella, P. Spradlin, F. Stagni, S. Stahl, O. Steinkamp, O. Stenyakin, S. Stevenson, S. Stoica, S. Stone, B. Storaci, S. Stracka, M. Straticiuc, U. Straumann, R. Stroili, V.K. Subbiah, L. Sun, W. Sutcliffe, K. Swientek, S. Swientek, V. Syropoulos, M. Szczekowski, P. Szczypka, D. Szilard, T. Szumlak, S. T'Jampens, M. Teklishyn, G. Tellarini, F. Teubert, C. Thomas, E. Thomas, J. van Tilburg, V. Tisserand, M. Tobin, S. Tolk, L. Tomassetti, D. Tonelli, S. Topp-Joergensen, N. Torr, E. Tournefier, S. Tourneur, M.T. Tran, M. Tresch, A. Tsaregorodtsev, P. Tsopelas, N. Tuning, M. Ubeda Garcia, A. Ukleja, A. Ustyuzhanin, U. Uwer, V. Vagnoni, G. Valenti, A. Vallier, R. Vazquez Gomez, P. Vazquez Regueiro, C. Vázquez Sierra, S. Vecchi, J.J. Velthuis, M. Veltri, G. Veneziano, M. Vesterinen, B. Viaud, D. Vieira, M. Vieites Diaz, X. Vilasis-Cardona, A. Vollhardt, D. Volyanskyy, D. Voong, A. Vorobyev, V. Vorobyev, C. Voß, H. Voss, J.A. de Vries, R. Waldi, C. Wallace, R. Wallace, J. Walsh, S. Wandernoth, J. Wang, D.R. Ward, N.K. Watson, D. Websdale, M. Whitehead, J. Wicht, D. Wiedner, G. Wilkinson, M.P. Williams, M. Williams, F.F. Wilson, J. Wimberley, J. Wishahi, W. Wislicki, M. Witek, G. Wormser, S.A. Wotton, S. Wright, S. Wu, K. Wyllie, Y. Xie, Z. Xing, Z. Xu, Z. Yang, X. Yuan, O. Yushchenko, M. Zangoli, M. Zavertyaev, F. Zhang, L. Zhang, W.C. Zhang, Y. Zhang, A. Zhelezov, A. Zhokhov, L. Zhong, and A. Zvyagin

Subjects
Physics, QC1-999
Abstract

Using a data sample of pp collisions corresponding to an integrated luminosity of 3 fb−1, the Ξb− and Ωb− baryons are reconstructed in the Ξb−→J/ψΞ− and Ωb−→J/ψΩ− decay modes and their lifetimes measured to be τ(Ξb−)=1.55−0.09+0.10 (stat)±0.03 (syst) ps,τ(Ωb−)=1.54−0.21+0.26 (stat)±0.05 (syst) ps. These are the most precise determinations to date. Both measurements are in good agreement with previous experimental results and with theoretical predictions.

Published
2014
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22. Measurement of the CP-violating phase ϕs in B¯s0→J/ψπ+π− decays

Author

R. Aaij, B. Adeva, M. Adinolfi, A. Affolder, Z. Ajaltouni, S. Akar, J. Albrecht, F. Alessio, M. Alexander, S. Ali, G. Alkhazov, P. Alvarez Cartelle, A.A. Alves, Jr., S. Amato, S. Amerio, Y. Amhis, L. An, L. Anderlini, J. Anderson, R. Andreassen, M. Andreotti, J.E. Andrews, R.B. Appleby, O. Aquines Gutierrez, F. Archilli, A. Artamonov, M. Artuso, E. Aslanides, G. Auriemma, M. Baalouch, S. Bachmann, J.J. Back, A. Badalov, V. Balagura, W. Baldini, R.J. Barlow, C. Barschel, S. Barsuk, W. Barter, V. Batozskaya, V. Battista, A. Bay, L. Beaucourt, J. Beddow, F. Bedeschi, I. Bediaga, S. Belogurov, K. Belous, I. Belyaev, E. Ben-Haim, G. Bencivenni, S. Benson, J. Benton, A. Berezhnoy, R. Bernet, M.-O. Bettler, M. van Beuzekom, A. Bien, S. Bifani, T. Bird, A. Bizzeti, P.M. Bjørnstad, T. Blake, F. Blanc, J. Blouw, S. Blusk, V. Bocci, A. Bondar, N. Bondar, W. Bonivento, S. Borghi, A. Borgia, M. Borsato, T.J.V. Bowcock, E. Bowen, C. Bozzi, T. Brambach, J. van den Brand, J. Bressieux, D. Brett, M. Britsch, T. Britton, J. Brodzicka, N.H. Brook, H. Brown, A. Bursche, G. Busetto, J. Buytaert, S. Cadeddu, R. Calabrese, M. Calvi, M. Calvo Gomez, A. Camboni, P. Campana, D. Campora Perez, A. Carbone, G. Carboni, R. Cardinale, A. Cardini, H. Carranza-Mejia, L. Carson, K. Carvalho Akiba, G. Casse, L. Cassina, L. Castillo Garcia, M. Cattaneo, Ch. Cauet, R. Cenci, M. Charles, Ph. Charpentier, S. Chen, S.-F. Cheung, N. Chiapolini, M. Chrzaszcz, K. Ciba, X. Cid Vidal, G. Ciezarek, P.E.L. Clarke, M. Clemencic, H.V. Cliff, J. Closier, V. Coco, J. Cogan, E. Cogneras, P. Collins, A. Comerma-Montells, A. Contu, A. Cook, M. Coombes, S. Coquereau, G. Corti, M. Corvo, I. Counts, B. Couturier, G.A. Cowan, D.C. Craik, M. Cruz Torres, S. Cunliffe, R. Currie, C. D'Ambrosio, J. Dalseno, P. David, P.N.Y. David, A. Davis, K. De Bruyn, S. De Capua, M. De Cian, J.M. De Miranda, L. De Paula, W. De Silva, P. De Simone, D. Decamp, M. Deckenhoff, L. Del Buono, N. Déléage, D. Derkach, O. Deschamps, F. Dettori, A. Di Canto, H. Dijkstra, S. Donleavy, F. Dordei, M. Dorigo, A. Dosil Suárez, D. Dossett, A. Dovbnya, K. Dreimanis, G. Dujany, F. Dupertuis, P. Durante, R. Dzhelyadin, A. Dziurda, A. Dzyuba, S. Easo, U. Egede, V. Egorychev, S. Eidelman, S. Eisenhardt, U. Eitschberger, R. Ekelhof, L. Eklund, I. El Rifai, Ch. Elsasser, S. Ely, S. Esen, T. Evans, A. Falabella, C. Färber, C. Farinelli, N. Farley, S. Farry, D. Ferguson, V. Fernandez Albor, F. Ferreira Rodrigues, M. Ferro-Luzzi, S. Filippov, M. Fiore, M. Fiorini, M. Firlej, C. Fitzpatrick, T. Fiutowski, M. Fontana, F. Fontanelli, R. Forty, O. Francisco, M. Frank, C. Frei, M. Frosini, J. Fu, E. Furfaro, A. Gallas Torreira, D. Galli, S. Gallorini, S. Gambetta, M. Gandelman, P. Gandini, Y. Gao, J. Garofoli, J. Garra Tico, L. Garrido, C. Gaspar, R. Gauld, L. Gavardi, G. Gavrilov, E. Gersabeck, M. Gersabeck, T. Gershon, Ph. Ghez, A. Gianelle, S. Giani', V. Gibson, L. Giubega, V.V. Gligorov, C. Göbel, D. Golubkov, A. Golutvin, A. Gomes, H. Gordon, C. Gotti, M. Grabalosa Gándara, R. Graciani Diaz, L.A. Granado Cardoso, E. Graugés, G. Graziani, A. Grecu, E. Greening, S. Gregson, P. Griffith, L. Grillo, O. Grünberg, B. Gui, E. Gushchin, Yu. Guz, T. Gys, C. Hadjivasiliou, G. Haefeli, C. Haen, S.C. Haines, S. Hall, B. Hamilton, T. Hampson, X. Han, S. Hansmann-Menzemer, N. Harnew, S.T. Harnew, J. Harrison, T. Hartmann, J. He, T. Head, V. Heijne, K. Hennessy, P. Henrard, L. Henry, J.A. Hernando Morata, E. van Herwijnen, M. Heß, A. Hicheur, D. Hill, M. Hoballah, C. Hombach, W. Hulsbergen, P. Hunt, N. Hussain, D. Hutchcroft, D. Hynds, M. Idzik, P. Ilten, R. Jacobsson, A. Jaeger, J. Jalocha, E. Jans, P. Jaton, A. Jawahery, F. Jing, M. John, D. Johnson, C.R. Jones, C. Joram, B. Jost, N. Jurik, M. Kaballo, S. Kandybei, W. Kanso, M. Karacson, T.M. Karbach, S. Karodia, M. Kelsey, I.R. Kenyon, T. Ketel, B. Khanji, C. Khurewathanakul, S. Klaver, O. Kochebina, M. Kolpin, I. Komarov, R.F. Koopman, P. Koppenburg, M. Korolev, A. Kozlinskiy, L. Kravchuk, K. Kreplin, M. Kreps, G. Krocker, P. Krokovny, F. Kruse, W. Kucewicz, M. Kucharczyk, V. Kudryavtsev, K. Kurek, T. Kvaratskheliya, V.N. La Thi, D. Lacarrere, G. Lafferty, A. Lai, D. Lambert, R.W. Lambert, E. Lanciotti, G. Lanfranchi, C. Langenbruch, B. Langhans, T. Latham, C. Lazzeroni, R. Le Gac, J. van Leerdam, J.-P. Lees, R. Lefèvre, A. Leflat, J. Lefrançois, S. Leo, O. Leroy, T. Lesiak, B. Leverington, Y. Li, M. Liles, R. Lindner, C. Linn, F. Lionetto, B. Liu, G. Liu, S. Lohn, I. Longstaff, J.H. Lopes, N. Lopez-March, P. Lowdon, H. Lu, D. Lucchesi, H. Luo, A. Lupato, E. Luppi, O. Lupton, F. Machefert, I.V. Machikhiliyan, F. Maciuc, O. Maev, S. Malde, G. Manca, G. Mancinelli, J. Maratas, J.F. Marchand, U. Marconi, C. Marin Benito, P. Marino, R. Märki, J. Marks, G. Martellotti, A. Martens, A. Martín Sánchez, M. Martinelli, D. Martinez Santos, F. Martinez Vidal, D. Martins Tostes, A. Massafferri, R. Matev, Z. Mathe, C. Matteuzzi, A. Mazurov, M. McCann, J. McCarthy, A. McNab, R. McNulty, B. McSkelly, B. Meadows, F. Meier, M. Meissner, M. Merk, D.A. Milanes, M.-N. Minard, N. Moggi, J. Molina Rodriguez, S. Monteil, M. Morandin, P. Morawski, A. Mordà, M.J. Morello, J. Moron, A.-B. Morris, R. Mountain, F. Muheim, K. Müller, R. Muresan, M. Mussini, B. Muster, P. Naik, T. Nakada, R. Nandakumar, I. Nasteva, M. Needham, N. Neri, S. Neubert, N. Neufeld, M. Neuner, A.D. Nguyen, T.D. Nguyen, C. Nguyen-Mau, M. Nicol, V. Niess, R. Niet, N. Nikitin, T. Nikodem, A. Novoselov, D.P. O'Hanlon, A. Oblakowska-Mucha, V. Obraztsov, S. Oggero, S. Ogilvy, O. Okhrimenko, R. Oldeman, G. Onderwater, M. Orlandea, J.M. Otalora Goicochea, P. Owen, A. Oyanguren, B.K. Pal, A. Palano, F. Palombo, M. Palutan, J. Panman, A. Papanestis, M. Pappagallo, C. Parkes, C.J. Parkinson, G. Passaleva, G.D. Patel, M. Patel, C. Patrignani, A. Pazos Alvarez, A. Pearce, A. Pellegrino, M. Pepe Altarelli, S. Perazzini, E. Perez Trigo, P. Perret, M. Perrin-Terrin, L. Pescatore, E. Pesen, K. Petridis, A. Petrolini, E. Picatoste Olloqui, B. Pietrzyk, T. Pilař, D. Pinci, A. Pistone, S. Playfer, M. Plo Casasus, F. Polci, A. Poluektov, E. Polycarpo, A. Popov, D. Popov, B. Popovici, C. Potterat, J. Prisciandaro, A. Pritchard, C. Prouve, V. Pugatch, A. Puig Navarro, G. Punzi, W. Qian, B. Rachwal, J.H. Rademacker, B. Rakotomiaramanana, M. Rama, M.S. Rangel, I. Raniuk, N. Rauschmayr, G. Raven, S. Reichert, M.M. Reid, A.C. dos Reis, S. Ricciardi, A. Richards, M. Rihl, K. Rinnert, V. Rives Molina, D.A. Roa Romero, P. Robbe, A.B. Rodrigues, E. Rodrigues, P. Rodriguez Perez, S. Roiser, V. Romanovsky, A. Romero Vidal, M. Rotondo, J. Rouvinet, T. Ruf, F. Ruffini, H. Ruiz, P. Ruiz Valls, G. Sabatino, J.J. Saborido Silva, N. Sagidova, P. Sail, B. Saitta, V. Salustino Guimaraes, C. Sanchez Mayordomo, B. Sanmartin Sedes, R. Santacesaria, C. Santamarina Rios, E. Santovetti, M. Sapunov, A. Sarti, C. Satriano, A. Satta, M. Savrie, D. Savrina, M. Schiller, H. Schindler, M. Schlupp, M. Schmelling, B. Schmidt, O. Schneider, A. Schopper, M.-H. Schune, R. Schwemmer, B. Sciascia, A. Sciubba, M. Seco, A. Semennikov, I. Sepp, N. Serra, J. Serrano, L. Sestini, P. Seyfert, M. Shapkin, I. Shapoval, Y. Shcheglov, T. Shears, L. Shekhtman, V. Shevchenko, A. Shires, R. Silva Coutinho, G. Simi, M. Sirendi, N. Skidmore, T. Skwarnicki, N.A. Smith, E. Smith, J. Smith, M. Smith, H. Snoek, M.D. Sokoloff, F.J.P. Soler, F. Soomro, D. Souza, B. Souza De Paula, B. Spaan, A. Sparkes, P. Spradlin, F. Stagni, M. Stahl, S. Stahl, O. Steinkamp, O. Stenyakin, S. Stevenson, S. Stoica, S. Stone, B. Storaci, S. Stracka, M. Straticiuc, U. Straumann, R. Stroili, V.K. Subbiah, L. Sun, W. Sutcliffe, K. Swientek, S. Swientek, V. Syropoulos, M. Szczekowski, P. Szczypka, D. Szilard, T. Szumlak, S. T'Jampens, M. Teklishyn, G. Tellarini, F. Teubert, C. Thomas, E. Thomas, J. van Tilburg, V. Tisserand, M. Tobin, S. Tolk, L. Tomassetti, D. Tonelli, S. Topp-Joergensen, N. Torr, E. Tournefier, S. Tourneur, M.T. Tran, M. Tresch, A. Tsaregorodtsev, P. Tsopelas, N. Tuning, M. Ubeda Garcia, A. Ukleja, A. Ustyuzhanin, U. Uwer, V. Vagnoni, G. Valenti, A. Vallier, R. Vazquez Gomez, P. Vazquez Regueiro, C. Vázquez Sierra, S. Vecchi, J.J. Velthuis, M. Veltri, G. Veneziano, M. Vesterinen, B. Viaud, D. Vieira, M. Vieites Diaz, X. Vilasis-Cardona, A. Vollhardt, D. Volyanskyy, D. Voong, A. Vorobyev, V. Vorobyev, C. Voß, H. Voss, J.A. de Vries, R. Waldi, C. Wallace, R. Wallace, J. Walsh, S. Wandernoth, J. Wang, D.R. Ward, N.K. Watson, D. Websdale, M. Whitehead, J. Wicht, D. Wiedner, G. Wilkinson, M.P. Williams, M. Williams, F.F. Wilson, J. Wimberley, J. Wishahi, W. Wislicki, M. Witek, G. Wormser, S.A. Wotton, S. Wright, S. Wu, K. Wyllie, Y. Xie, Z. Xing, Z. Xu, Z. Yang, X. Yuan, O. Yushchenko, M. Zangoli, M. Zavertyaev, L. Zhang, W.C. Zhang, Y. Zhang, A. Zhelezov, A. Zhokhov, L. Zhong, and A. Zvyagin

Subjects
Physics, QC1-999
Abstract

The mixing-induced CP-violating phase ϕs in Bs0 and B¯s0 decays is measured using the J/ψπ+π− final state in data, taken from 3 fb−1 of integrated luminosity, collected with the LHCb detector in 7 and 8 TeV centre-of-mass pp collisions at the LHC. A time-dependent flavour-tagged amplitude analysis, allowing for direct CP violation, yields a value for the phase ϕs=70±68±8 mrad. This result is consistent with the Standard Model expectation and previous measurements.

Published
2014
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23. P012 The administration of mm-miR-378a-3p exacerbates chronic inflammation and fibrosis in a murine intestinal model

Author

M Seco-Cervera, D Argilés-Arberola, C Bauset, L Lis-López, S Coll, J Cosín-Roger, D Ortiz-Masià, S Calatayud, and M D Barrachina

Subjects
Gastroenterology, General Medicine
Abstract

Background Fibrosis constitute an important complication of CD. MicroRNAs (miRNAs), which are small RNA molecules that regulate gene expression, have been shown to participate in the molecular interactions of both inflammation and fibrosis. Lower levels of miR-378a-3p have been reported associated to murine liver fibrosis (Hyun et al. DOI: 10.1038/ncomms10993) and we analyze here the relevance of miR-378a-3p on intestinal fibrosis. Methods B57BL/6 mice were intravenously injected with 2,5mg/kg of negative control (NC) or mm-miR-378a-3p mimic, twice a week and received vehicle or Dextran Sulfate Sodium (DSS) for 2 cycles (7 days drinking DSS 2% in water solution followed by 10 days drinking water). Body weight and DAI score was obtained every day and the colon was collected after sacrifice. Sirius and hematoxylin-eosin dyes were employed to determine the fibrosis and structural state in 5µm slides of intestinal tissue. Gene expression and miRNA profiles were analyzed by RT-qPCR. Human small intestinal fibroblasts (HSIF; P10760, Innoprot, Spain) were transfected with 20nM of NC or hsa-miR-378a-3p mimic during 24h. Results No significant changes in body weight, DAI score, and colon length were detected between mice receiving NC and those receiving mimic, all along the two DSS cycles. Colon of mice treated with DSS, exhibited a significant diminution in the mRNA expression of mm-miR-378a-3p compared with naïve samples. In DSS-treated mice, the iv administration of the mimic compared with the NC: a) significantly increased levels of miR-378a-3p in the colon; b) increased the number of neutrophils, and heightened changes in the glandular epithelia and architectural distortion (figure 1a) C) decreased the number of lymphoid follicles (figure 1a); d) slightly increased collagen deposition, as analyzed by sirius red (figure 1b) and e) significantly increased the mRNA expression of Tgfb1, Il1b, and Mmp2. Treatment of human intestinal fibroblasts with hsa-miR-378a-3p mimic did not significant modify the mRNA expression of markers of fibrosis but it significantly increased the mRNA expression of two antiapoptotic molecules BCL2 and MCL1. Conclusion Levels of mm-miR-378a-3p are diminished in a murine model of intestinal fibrosis; The exogenous administration of miR-378a-3p, increased the acute inflammatory response and the expression of fibrosis markers in murine fibrotic colon and the expression of antiapoptotic molecules in human intestinal fibroblasts.

Published
2023
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24. Hydrolysis of a carbamate triggered by coordination of metal ions

Author

Sandra Fernández-Fariña, Miguel Martínez-Calvo, María J. Romero, José M. Seco, Guillermo Zaragoza, Rosa Pedrido, and Ana M. González-Noya

Subjects
Inorganic Chemistry, Ions, Metals, Hydrolysis, Carbamates, Ligands
Abstract

The coordination of metal ions to a carbamate ligand triggers its hydrolysis, which ends up in self-immolation of the complex releasing new metal species, a pendant molecule (A) and CO2.

Published
2022

25. Multifunctional Lanthanide-Based Metal-Organic Frameworks Derived from 3-Amino-4-hydroxybenzoate: Single-Molecule Magnet Behavior, Luminescent Properties for Thermometry, and CO

Author

Estitxu, Echenique-Errandonea, Ricardo F, Mendes, Flávio, Figueira, Duane, Choquesillo-Lazarte, Garikoitz, Beobide, Javier, Cepeda, Duarte, Ananias, Antonio, Rodríguez-Diéguez, Filipe A, Almeida Paz, and José M, Seco

Abstract

Herein, we describe and study a new family of isostructural multifunctional metal-organic frameworks (MOFs) with the formula {[Ln

Published
2022

26. Experimental and DFT studies on Hexacoordinated acyl(alkyl)and Pentacooordinated Hydroxyalkyl(phosphinite)erhodium(III). Catalytic Hydrolysis of Ammonia Borane

Author

Antonio J. Mota, José M. Seco, Antonio Rodríguez-Diéguez, Susan Azpeitia, Claudio Mendicute-Fierro, María A. Garralda, and Miguel A. Huertos

Subjects
Inorganic Chemistry, chemistry.chemical_classification, C c coupling, chemistry.chemical_compound, Phosphinite, Chemistry, Hydrogen bond, Ammonia borane, Polymer chemistry, Hydrogen transfer, Homogeneous catalysis, Catalytic hydrolysis, Alkyl
Published
2021
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27. A novel yttrium-based metal–organic framework for the efficient solvent-free catalytic synthesis of cyanohydrin silyl ethers

Author

Sara Rojas, Estitxu Echenique-Errandonea, Ignacio Fernández, Javier Cepeda, José M. Seco, Juana M. Pérez, and Antonio Rodríguez-Diéguez

Subjects
Lanthanide, Materials science, Silylation, Ligand, chemistry.chemical_element, Yttrium, Catalysis, Inorganic Chemistry, chemistry.chemical_compound, chemistry, Polymer chemistry, Hydroxide, Metal-organic framework, Cyanohydrin
Abstract

A new porous metal–organic framework (MOF) with the chemical formula [Y5L6(OH)3(DMF)3]·5H2O (1) (where L = 3-amino-4-hydroxybenzoate) has been prepared by a solvothermal procedure. The structural characterization reveals that this material consists of a robust three-dimensional metal–organic framework (MOF) grown with clusters formed by Y(III) and hydroxide anions joined to one another by the ligand, giving rise to an open structure with interconnected microchannels with variable dimensions. This assembled set has shown to possess a fascinating catalytic activity for the cyanosilylation of a broad range of aldehydes and ketones with exceptional recyclability, a solvent-free medium, and one order of magnitude lower catalyst loading compared to all related lanthanide-based MOFs described so far in the literature.

Published
2021
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28. Observation of X(3872) production in pp collisions at $\sqrt{s}=7\mbox{~TeV}$

Author

The LHCb Collaboration, R. Aaij, C. Abellan Beteta, B. Adeva, M. Adinolfi, C. Adrover, A. Affolder, Z. Ajaltouni, J. Albrecht, F. Alessio, M. Alexander, G. Alkhazov, P. Alvarez Cartelle, A. A. Alves, S. Amato, Y. Amhis, J. Anderson, R. B. Appleby, O. Aquines Gutierrez, F. Archilli, L. Arrabito, A. Artamonov, M. Artuso, E. Aslanides, G. Auriemma, S. Bachmann, J. J. Back, D. S. Bailey, V. Balagura, W. Baldini, R. J. Barlow, C. Barschel, S. Barsuk, W. Barter, A. Bates, C. Bauer, Th. Bauer, A. Bay, I. Bediaga, S. Belogurov, K. Belous, I. Belyaev, E. Ben-Haim, M. Benayoun, G. Bencivenni, S. Benson, J. Benton, R. Bernet, M.-O. Bettler, M. van Beuzekom, A. Bien, S. Bifani, T. Bird, A. Bizzeti, P. M. Bjørnstad, T. Blake, F. Blanc, C. Blanks, J. Blouw, S. Blusk, A. Bobrov, V. Bocci, A. Bondar, N. Bondar, W. Bonivento, S. Borghi, A. Borgia, T. J. V. Bowcock, C. Bozzi, T. Brambach, J. van den Brand, J. Bressieux, D. Brett, M. Britsch, T. Britton, N. H. Brook, H. Brown, A. Büchler-Germann, I. Burducea, A. Bursche, J. Buytaert, S. Cadeddu, O. Callot, M. Calvi, M. Calvo Gomez, A. Camboni, P. Campana, A. Carbone, G. Carboni, R. Cardinale, A. Cardini, L. Carson, K. Carvalho Akiba, G. Casse, M. Cattaneo, Ch. Cauet, M. Charles, Ph. Charpentier, N. Chiapolini, K. Ciba, X. Cid Vidal, G. Ciezarek, P. E. L. Clarke, M. Clemencic, H. V. Cliff, J. Closier, C. Coca, V. Coco, J. Cogan, P. Collins, A. Comerma-Montells, F. Constantin, A. Contu, A. Cook, M. Coombes, G. Corti, G. A. Cowan, R. Currie, C. D’Ambrosio, P. David, P. N. Y. David, I. De Bonis, S. De Capua, M. De Cian, F. De Lorenzi, J. M. De Miranda, L. De Paula, P. De Simone, D. Decamp, M. Deckenhoff, H. Degaudenzi, L. Del Buono, C. Deplano, D. Derkach, O. Deschamps, F. Dettori, J. Dickens, H. Dijkstra, P. Diniz Batista, F. Domingo Bonal, S. Donleavy, F. Dordei, A. Dosil Suárez, D. Dossett, A. Dovbnya, F. Dupertuis, R. Dzhelyadin, A. Dziurda, S. Easo, U. Egede, V. Egorychev, S. Eidelman, D. van Eijk, F. Eisele, S. Eisenhardt, R. Ekelhof, L. Eklund, Ch. Elsasser, D. Elsby, D. Esperante Pereira, L. Estève, A. Falabella, E. Fanchini, C. Färber, G. Fardell, C. Farinelli, S. Farry, V. Fave, V. Fernandez Albor, M. Ferro-Luzzi, S. Filippov, C. Fitzpatrick, M. Fontana, F. Fontanelli, R. Forty, M. Frank, C. Frei, M. Frosini, S. Furcas, A. Gallas Torreira, D. Galli, M. Gandelman, P. Gandini, Y. Gao, J-C. Garnier, J. Garofoli, J. Garra Tico, L. Garrido, D. Gascon, C. Gaspar, N. Gauvin, M. Gersabeck, T. Gershon, Ph. Ghez, V. Gibson, V. V. Gligorov, C. Göbel, D. Golubkov, A. Golutvin, A. Gomes, H. Gordon, M. Grabalosa Gándara, R. Graciani Diaz, L. A. Granado Cardoso, E. Graugés, G. Graziani, A. Grecu, E. Greening, S. Gregson, B. Gui, E. Gushchin, Yu. Guz, T. Gys, G. Haefeli, C. Haen, S. C. Haines, T. Hampson, S. Hansmann-Menzemer, R. Harji, N. Harnew, J. Harrison, P. F. Harrison, T. Hartmann, J. He, V. Heijne, K. Hennessy, P. Henrard, J. A. Hernando Morata, E. van Herwijnen, E. Hicks, K. Holubyev, P. Hopchev, W. Hulsbergen, P. Hunt, T. Huse, R. S. Huston, D. Hutchcroft, D. Hynds, V. Iakovenko, P. Ilten, J. Imong, R. Jacobsson, A. Jaeger, M. Jahjah Hussein, E. Jans, F. Jansen, P. Jaton, B. Jean-Marie, F. Jing, M. John, D. Johnson, C. R. Jones, B. Jost, M. Kaballo, S. Kandybei, M. Karacson, T. M. Karbach, J. Keaveney, I. R. Kenyon, U. Kerzel, T. Ketel, A. Keune, B. Khanji, Y. M. Kim, M. Knecht, P. Koppenburg, A. Kozlinskiy, L. Kravchuk, K. Kreplin, M. Kreps, G. Krocker, P. Krokovny, F. Kruse, K. Kruzelecki, M. Kucharczyk, T. Kvaratskheliya, V. N. La Thi, D. Lacarrere, G. Lafferty, A. Lai, D. Lambert, R. W. Lambert, E. Lanciotti, G. Lanfranchi, C. Langenbruch, T. Latham, C. Lazzeroni, R. Le Gac, J. van Leerdam, J.-P. Lees, R. Lefèvre, A. Leflat, J. Lefrançois, O. Leroy, T. Lesiak, L. Li, L. Li Gioi, M. Lieng, M. Liles, R. Lindner, C. Linn, B. Liu, G. Liu, J. von Loeben, J. H. Lopes, E. Lopez Asamar, N. Lopez-March, H. Lu, J. Luisier, A. Mac Raighne, F. Machefert, I. V. Machikhiliyan, F. Maciuc, O. Maev, J. Magnin, S. Malde, R. M. D. Mamunur, G. Manca, G. Mancinelli, N. Mangiafave, U. Marconi, R. Märki, J. Marks, G. Martellotti, A. Martens, L. Martin, A. Martín Sánchez, D. Martinez Santos, A. Massafferri, Z. Mathe, C. Matteuzzi, M. Matveev, E. Maurice, B. Maynard, A. Mazurov, G. McGregor, R. McNulty, M. Meissner, M. Merk, J. Merkel, R. Messi, S. Miglioranzi, D. A. Milanes, M.-N. Minard, J. Molina Rodriguez, S. Monteil, D. Moran, P. Morawski, R. Mountain, I. Mous, F. Muheim, K. Müller, R. Muresan, B. Muryn, B. Muster, M. Musy, J. Mylroie-Smith, P. Naik, T. Nakada, R. Nandakumar, I. Nasteva, M. Nedos, M. Needham, N. Neufeld, C. Nguyen-Mau, M. Nicol, V. Niess, N. Nikitin, A. Nomerotski, A. Novoselov, A. Oblakowska-Mucha, V. Obraztsov, S. Oggero, S. Ogilvy, O. Okhrimenko, R. Oldeman, M. Orlandea, J. M. Otalora Goicochea, P. Owen, K. Pal, J. Palacios, A. Palano, M. Palutan, J. Panman, A. Papanestis, M. Pappagallo, C. Parkes, C. J. Parkinson, G. Passaleva, G. D. Patel, M. Patel, S. K. Paterson, G. N. Patrick, C. Patrignani, C. Pavel-Nicorescu, A. Pazos Alvarez, A. Pellegrino, G. Penso, M. Pepe Altarelli, S. Perazzini, D. L. Perego, E. Perez Trigo, A. Pérez-Calero Yzquierdo, P. Perret, M. Perrin-Terrin, G. Pessina, A. Petrella, A. Petrolini, A. Phan, E. Picatoste Olloqui, B. Pie Valls, B. Pietrzyk, T. Pilař, D. Pinci, R. Plackett, S. Playfer, M. Plo Casasus, G. Polok, A. Poluektov, E. Polycarpo, D. Popov, B. Popovici, C. Potterat, A. Powell, J. Prisciandaro, V. Pugatch, A. Puig Navarro, W. Qian, J. H. Rademacker, B. Rakotomiaramanana, M. S. Rangel, I. Raniuk, G. Raven, S. Redford, M. M. Reid, A. C. dos Reis, S. Ricciardi, K. Rinnert, D. A. Roa Romero, P. Robbe, E. Rodrigues, F. Rodrigues, P. Rodriguez Perez, G. J. Rogers, S. Roiser, V. Romanovsky, M. Rosello, J. Rouvinet, T. Ruf, H. Ruiz, G. Sabatino, J. J. Saborido Silva, N. Sagidova, P. Sail, B. Saitta, C. Salzmann, M. Sannino, R. Santacesaria, C. Santamarina Rios, R. Santinelli, E. Santovetti, M. Sapunov, A. Sarti, C. Satriano, A. Satta, M. Savrie, D. Savrina, P. Schaack, M. Schiller, S. Schleich, M. Schlupp, M. Schmelling, B. Schmidt, O. Schneider, A. Schopper, M.-H. Schune, R. Schwemmer, B. Sciascia, A. Sciubba, M. Seco, A. Semennikov, K. Senderowska, I. Sepp, N. Serra, J. Serrano, P. Seyfert, M. Shapkin, I. Shapoval, P. Shatalov, Y. Shcheglov, T. Shears, L. Shekhtman, O. Shevchenko, V. Shevchenko, A. Shires, R. Silva Coutinho, T. Skwarnicki, A. C. Smith, N. A. Smith, E. Smith, K. Sobczak, F. J. P. Soler, A. Solomin, F. Soomro, B. Souza De Paula, B. Spaan, A. Sparkes, P. Spradlin, F. Stagni, S. Stahl, O. Steinkamp, S. Stoica, S. Stone, B. Storaci, M. Straticiuc, U. Straumann, V. K. Subbiah, S. Swientek, M. Szczekowski, P. Szczypka, T. Szumlak, S. T’Jampens, E. Teodorescu, F. Teubert, C. Thomas, E. Thomas, J. van Tilburg, V. Tisserand, M. Tobin, S. Topp-Joergensen, N. Torr, E. Tournefier, M. T. Tran, A. Tsaregorodtsev, N. Tuning, M. Ubeda Garcia, A. Ukleja, P. Urquijo, U. Uwer, V. Vagnoni, G. Valenti, R. Vazquez Gomez, P. Vazquez Regueiro, S. Vecchi, J. J. Velthuis, M. Veltri, B. Viaud, I. Videau, X. Vilasis-Cardona, J. Visniakov, A. Vollhardt, D. Volyanskyy, D. Voong, A. Vorobyev, H. Voss, S. Wandernoth, J. Wang, D. R. Ward, N. K. Watson, A. D. Webber, D. Websdale, M. Whitehead, D. Wiedner, L. Wiggers, G. Wilkinson, M. P. Williams, M. Williams, F. F. Wilson, J. Wishahi, M. Witek, W. Witzeling, S. A. Wotton, K. Wyllie, Y. Xie, F. Xing, Z. Xing, Z. Yang, R. Young, O. Yushchenko, M. Zavertyaev, F. Zhang, L. Zhang, W. C. Zhang, Y. Zhang, A. Zhelezov, L. Zhong, E. Zverev, and A. Zvyagin

Subjects
Large Hadron Collider, Transverse Momentum, Systematic Uncertainty, Momentum Scale, LHCb Collaboration, Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract Using 34.7 pb−1 of data collected with the LHCb detector, the inclusive production of the X(3872) meson in pp collisions at $\sqrt{s}=7\mbox{~TeV}$ is observed for the first time. Candidates are selected in the X(3872)→J/ψπ + π − decay mode, and used to measure where σ(pp→X(3872)+anything) is the inclusive production cross section of X(3872) mesons with rapidity in the range 2.5–4.5 and transverse momentum in the range 5–20 GeV/c. In addition the masses of both the X(3872) and ψ(2S) mesons, reconstructed in the J/ψπ + π − final state, are measured to be $$m_{X(3872)} = 3871.95 \pm0.48 \ (\mathrm{stat}) \pm0.12 \ (\mathrm {syst})\ \mathrm{MeV}/c^2 $$ and $$m_{\psi(2S)} = 3686.12\pm0.06 \ (\mathrm{stat}) \pm0.10 \ (\mathrm {syst})\ \mathrm{MeV}/c^2. $$

Published
2012
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29. Review article vascular liver anatomy and main variants: what the radiologist must know

Author

M Seco, P Donato, J Costa, A Bernardes, and F Caseiro-Alves

Subjects
Liver, anatomy, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Advances in surgical techniques are extremely demanding regarding the accuracy and level of detail expected for display of the vascular anatomy of the liver. Precise knowledge of the arterial, portal and hepatic vein territories are mandatory whenever a liver intervention is planned. Sectional anatomy can now be routinely performed on multidetector computed tomography (MDCT) with volumetric data and isotropic voxel display, by means of sub-millimetric slice thickness acquisition. The relevant vascular information can thus be gathered, reviewed and post-processed with unprecedented clarity, obviating the need for digital subtraction angiography. The scope of the present paper is to review the normal vascular liver anatomy, its most relevant variants including additional sources of vascular inflow. Apart from providing the surgeon with a detailed vascular and parenchymal roadmap knowledge of imaging findings may avoid potential confusion with pathologic processes.

Published
2010
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30. A Mixed Heterobimetallic Y/Eu-MOF for the Cyanosilylation and Hydroboration of Carbonyls

Author

Estitxu Echenique-Errandonea, Mireya E. López-Vargas, Juana M. Pérez, Sara Rojas, Duane Choquesillo-Lazarte, José M. Seco, Ignacio Fernández, and Antonio Rodríguez-Diéguez

Subjects
heterobimetallic, metal-organic framework, cyanosilylation, hydroboration, yttrium, europium, Cyanosilylation, Catalysis, Metal-organic Frameworks (MOFs), Europium, Hydroboration, Heterobimetallic, Yttrium, Physical and Theoretical Chemistry
Abstract

Supplementary Materials The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/catal12030299/s1. Table S1: Elemental analysis of compounds Y/Eu-MOF. Table S2: ICP-AES results of compound Y/Eu-MOF. Table S3: Crystallographic data and structure refinement details of compound Y/Eu-MOF. Table S4: Selected bond lengths (Å) and angles (°) for compound Y/Eu-MOF. Table S5: Table of the continuous Shape Measurements for the MN3O6 coordination environment. Table S6: Table of the continuous Shape Measurements for the MO8 coordination environment. Table S7: Electrophoretic mobility and ζ-potential dependence, with the pH of the Y/Eu-MOFs particles dispersed in water. Conductivity fixed at 330 µS/cm. Table S8: Optimization of the reaction conditions in the hydroboration reaction. Table S9: Green metrics calculated for Y/Eu-MOF catalyst. Table S10: Catalytic cyanosilylation of benzaldehyde performances of Ln-MOFs, as reported in the literature. Figure S1: Figure of the pattern matching analysis and experimental PXRD for Y/Eu-MOF. Figure S2: Figure of the infrared spectra of the ligand and Y/Eu-MOF. Figure S3: SEM and EDS mapping of bulk material of Y/Eu-MOF. Figure S4: Images and particle size distribution (an overall of 250 particles) in the deposited fraction of Y/Eu-MOF catalyst non-suspended in water (about a 68% of the total amount), determined from optical microscope images. Figure S5: Images and particle size distribution (an overall of 250 particles) of Y/Eu-MOF crystals in the fraction steadily suspended in water (about a 32% of the total amount), determined from optical microscope images. Figure S6: Comparation of the particle size distribution of Y/Eu-MOF in the fraction steadily suspended in water and the non-suspended, determined from optical microscope images. Figure S7: Calibration line of conductivity (µS/cm) vs [NaCl] (mol/L). Figure S8: ζ-potential (mV) dependence with the pH of the Y/Eu-MOF. All the measurements were performed with constant conductivity of 330 µS/cm. Figure S9: Electrophoretic mobility (µm·cm/V·s) dependence with the pH of the Y/Eu-MOF. All the measurements were performed with constant conductivity of 330 µS/cm. Figure S10: Study of the recyclability of Y/Eu-MOF (0.5 mol%) catalyst on the cyanosilylation and hydroboration reaction of acetophenone as carbonyl substrate. Figure S11: Analysis of the TOF (h−1) obtained in the cyanosilylation reaction of acetophenone at different times of reaction with Y/Eu-MOF (0.5 mol%), with the optimized reaction conditions. Figure S12: Analysis of the TOF (h−1) obtained in the hydroboration reaction acetophenone at different times of reaction with Y/Eu-MOF (0.5 mol%), with the optimized reaction conditions. Scheme S1: Reaction conditions used for the study of recyclability of Y/Eu-MOF catalysts in the cyanosilylation reaction. Scheme S2: Reaction conditions used for the study of recyclability of Y/Eu-MOF catalysts in the hydroboration reaction. Scheme S3: Leaching test, carried out after the first and second cycles., Funding: This research has been funded by the State Research Agency (grants CTQ2017-84334-R and PGC2018-102052-B-C21) of the Spanish Ministry of Science, Innovation and Universities, the European Union (European Regional Development Fund—ERDF), Junta de Andalucía (P20_01041, UAL2020-AGR-B1781, B-FQM-734-UGR20 and FQM-394). E.E., S.R., and J.P. acknowledge the Government of the Basque Country, Juan de la Cierva Incorporación (grant no. IJC2019-038894-I) and University of Almeria (grant no. HIPATIA2021_04) for their respective fellows, Herein, to the best of our knowledge, the first heterobimetallic Y/Eu porous metal–organic framework (MOF), based on 3-amino-4-hydroxybenzoic acid (H2L) ligand, with the following formulae {[Y3.5Eu1.5L6(OH)3(H2O)3]·12DMF}n (in advance, namely Y/Eu-MOF), is described. The three-dimensional structure has been synthesized by solvothermal routes and thoroughly characterized, by means of single crystal X-ray diffraction, powder X-ray diffraction, electronic microscopy, ICP-AES, electrophoretic mobility, and FTIR spectra. Intriguingly, the porous nature allows for coordinated solvent molecules displacement, yielding unsaturated metal centers, which can act as a Lewis acid catalyst. This novel supramolecular entity has been tested in cyanosilylation and hydroboration reactions on carbonyl substrates of a diverse nature, exhibiting an extraordinary activity., Cierva Incorporación IJC2019-038894-I, State Research Agency CTQ2017-84334-R, PGC2018-102052-B-C21, University of Almeria HIPATIA2021_04, Ministerio de Ciencia, Innovación y Universidades, European Commission, European Regional Development Fund, Junta de Andalucía B-FQM-734-UGR20, FQM-394, IJC2019-038894-I, P20_01041, UAL2020-AGR-B1781

Published
2022

32. P038 Notch pathway in fibrosis: a new anti-fibrotic therapy in Crohn's disease?

Author

S Marti-Chafer, E Jimenez-Mallen, T Mendoza, D C Macias-Ceja, C Bauset, M Seco-Cervera, S Calatayud, J Cosin-Roger, M D Barrachina, and D Ortiz-Masiá

Subjects
Gastroenterology, General Medicine
Abstract

Background Fibrosis represent the main complications related to Crohn's disease (CD). Notch signalling mediate fibrogenic process, including epithelial-mesenchymal transition (EMT) and fibroblast senescence but its role in CD fibrosis is currently unknown. Previous studies have shown a high expression of NOTCH4, NOTCH3, DLL3 and DLL4 in CD fibrotic tissue. DLL4 mainly activates transcription factors involved in EMT, and macrophages could act as a possible source of DLL4 (Edo, et al., 2022. JCC (i200)).The general aim of the present study is to determine the possible potential of Notch pathway as a therapeutic target in intestinal fibrosis associated with CD. Specifically, we pretend: to analyze the localization of NOTCH3/4 receptors in the intestinal tissue of patients with CD complicated; to study the relevance of NOTCH3/4 receptors in the EMT; to study the relevance of Notch pathway in the senescence of intestinal fibroblast. Methods We have analyzed in intestinal samples from CD patients with complicated lesions: the localization of NOTCH3/4 receptors by IH and the protein expression of senescence markers (BCL2 and P53) by WB. We carry out in vitro studies and analyze: the protein expression of HES1 (effector Notch pathway) and EMT markers in DLL4-HT29 treated cells transfected with miNOTCH3 or miNOTCH4; and the protein expression of senescence proteins in HSIF fibroblasts treated with DLL4 or DLL3. Results NOTCH3 was located preferentially in muscular areas -muscularis mucosa, endothelium and muscularis externa- with a striking staining of infiltrated cells in the mucosa of the unaffected area. NOTCH4 is found more specifically in the crypts of the mucosa, as well as in cells of the lamina propria of the unaffected mucosa. The expression of senescence proteins in the tissue showed elevated levels of BCL2 and P53, compared to the unaffected tissue of the same patient. DLL4 increased the protein expression of EMT markers in HT29 cells, and NOTCH4 silencing significantly reverted the expression of these EMT markers. NOTCH3 silencing produced no significant changes after DLL4-HT29 treatment. DLL3, and not DLL4, produced in intestinal fibroblasts a significant increase in the protein expression levels of BCL2, and P53, compared to the vehicle (Figure). Conclusion NOTCH pathway is involved in the regulation of key cellular functions and processes essential for the pathogenesis of intestinal fibrosis in CD patients. DLL4-NOTCH4 interaction triggers transcription factors involved in mesenchymal epithelial transition in colonic epithelial cells, while DLL3 seems to have a more relevant role in activation of senescence in fibroblasts.

Published
2023
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33. Influence of thermally induced structural transformations on the magnetic and luminescence properties of tartrate-based chiral lanthanide organic-frameworks

Author

Antonio Rodríguez-Diéguez, Eider San Sebastian, Alessio Terenzi, Uxua Huizi-Rayo, Javier Cepeda, Andoni Zabala-Lekuona, Carlos Cruz, José M. Seco, José Ángel García, Juan M. Cuerva, Huizi-Rayo U., Zabala-Lekuona A., Terenzi A., Cruz C.M., Cuerva J.M., Rodriguez-Dieguez A., Garcia J.A., Seco J.M., San Sebastian E., and Cepeda J.

Subjects
Lanthanide, Materials science, Photoluminescence, lanthanide organic-frameworks, MOF, chiral, circular dichroism, General Chemistry, Tartrate, Crystallography, chemistry.chemical_compound, chemistry, Settore CHIM/03 - Chimica Generale E Inorganica, Magnet, Materials Chemistry, Molecule, Isostructural, Enantiomer, Luminescence
Abstract

This work reports on the synthesis and characterization of five enantiomeric pairs of isostructural 3D metal-organic frameworks (MOFs) with the general formula {[Ln2(μ4-tar)2(μ-tar)(H2O)2]·xH2O}n [where Ln(iii) = Tb (Tb-L and Tb-D), Dy (Dy-L and Dy-D), Ho (Ho-L and Ho-D), Er (Er-L and Er-D) and Tm (Tm-L and Tm-D); tar = tartrate (d- or l-) and x = 3 or 4 depending on the counterpart], which possess interesting luminescence and magnetic properties. These MOFs undergo progressive and reversible dehydration processes upon controlled heating yielding three crystalline phases (Ln-L′, Ln-L′′ and Ln-L′′′). Alternating current magnetic measurements on Tb, Dy and Er-based compounds exhibit field induced single-molecule magnet behavior dominated by QTM, which is partially suppressed when diluted on a Y-based matrix. Tartrate ligands show poor room temperature sensitization of Tb and Dy centers that is enhanced at low temperature (10 K), even enabling weak Tm-based emission. More interestingly, the dehydration modulates both magnetic and photoluminescence properties on the basis of both the distortions occurring in the coordination shells and a decrease of water molecules acting as quenchers, respectively, endowing these materials with potential humidity sensing capacity. Remarkably, the Tb-based MOF shows circularly polarized luminescence (CPL), being one of the examples of this very scarce family of CPL emitters reported so far. This journal is

Published
2020
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34. Tratamiento de la incontinencia urinaria tras prostatectomía: una revisión sistemática

Author

I. Da Cuña-Carrera, Alejandra Alonso-Calvete, M. Seco-Leal, and Yoana González-González

Subjects
030506 rehabilitation, 03 medical and health sciences, 0302 clinical medicine, Physical Therapy, Sports Therapy and Rehabilitation, 0305 other medical science, 030217 neurology & neurosurgery
Abstract

Resumen Introduccion El cancer de prostata es una de las neoplasias malignas mas frecuentes entre los hombres europeos. La opcion estandar de tratamiento es la prostatectomia radical, y una de las principales complicaciones de este tipo de intervencion es la incontinencia urinaria, la cual disminuye la calidad de vida de los pacientes. El tratamiento de primera eleccion es el conservador: entrenamiento de la musculatura del suelo pelvico (EMSP), biofeedback (BFB), estimulacion electrica funcional, etc., por lo que se llevara a cabo una revision bibliografica con el objetivo de ahondar en los distintos tratamientos de fisioterapia para tratar la incontinencia urinaria tras prostatectomia. Material y metodos Se realizo una busqueda bibliografica en enero de 2019 en las bases de datos Medline, Pubmed, Scopus y Cinahl empleando los descriptores «Urinary Incontinence», «Prostatectomy» y «Physical Therapy Modalities». Se obtuvo un total de 65 resultados, de los cuales solo 12 fueron seleccionados tras aplicar los criterios de inclusion y exclusion. Resultados Los articulos analizados realizan la combinacion de EMSP y otras intervenciones (BFB, BFB y principios de estabilizacion segmentaria de la columna vertebral, BFB y estimulacion electrica funcional, terapia novedosa de vibracion, diferentes ejercicios aerobicos, Pilates e hipopresivos y Pilates y estimulacion anal electrica). Conclusion El EMSP de forma aislada o combinandolo con otras tecnicas obtiene resultados favorables en la recuperacion de la continencia urinaria tras prostatectomia.

Published
2020
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35. New Rimocidin/CE-108 Derivatives Obtained by a Crotonyl-CoA Carboxylase/Reductase Gene Disruption in Streptomyces diastaticus var. 108: Substrates for the Polyene Carboxamide Synthase PcsA.

Author

Leticia Escudero, Mahmoud Al-Refai, Cristina Nieto, Hartmut Laatsch, Francisco Malpartida, and Elena M Seco

Subjects
Medicine, Science
Abstract

The rimJ gene, which codes for a crotonyl-CoA carboxylase/reductase, lies within the biosynthetic gene cluster for two polyketides belonging to the polyene macrolide group (CE-108 and rimocidin) produced by Streptomyces diastaticus var. 108. Disruption of rimJ by insertional inactivation gave rise to a recombinant strain overproducing new polyene derivatives besides the parental CE-108 (2a) and rimocidin (4a). The structure elucidation of one of them, CE-108D (3a), confirmed the incorporation of an alternative extender unit for elongation step 13. Other compounds were also overproduced in the fermentation broth of rimJ disruptant. The new compounds are in vivo substrates for the previously described polyene carboxamide synthase PcsA. The rimJ disruptant strain, constitutively expressing the pcsA gene, allowed the overproduction of CE-108E (3b), the corresponding carboxamide derivative of CE-108D (3a), with improved pharmacological properties.

Published
2015
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36. Wilm’s tumor 1 promotes memory flexibility

Author

Georgia E. Hodes, Sarah A. Stern, Jens Hansen, Ali Sharma, Evren U. Azeloglu, Vicki Huff, Robert D. Blitzer, Marc R. Birtwistle, Leonardo Munari, Ravi Iyengar, Nikos Tzavaras, Hossein Aleyasin, Chiara Mariottini, Scott J. Russo, Cristina M. Alberini, Virginia Gao, Joseph M. Seco, and Ellen Gunzel

Subjects
Male, 0301 basic medicine, Science, Long-Term Potentiation, General Physics and Astronomy, Hippocampus, 02 engineering and technology, behavioral disciplines and activities, Article, General Biochemistry, Genetics and Molecular Biology, Rats, Sprague-Dawley, Mice, 03 medical and health sciences, Forgetting, Memory, mental disorders, Animals, WT1 Proteins, lcsh:Science, CA1 Region, Hippocampal, Mice, Knockout, Neurons, Memory Disorders, Neuronal Plasticity, Multidisciplinary, Behavior, Animal, Flexibility (personality), Long-term potentiation, Fear, General Chemistry, Extinction (psychology), Impaired memory, 021001 nanoscience & nanotechnology, Rats, Repressor Proteins, 030104 developmental biology, Synaptic plasticity, lcsh:Q, Sequence learning, 0210 nano-technology, Psychology, Neuroscience
Abstract

Under physiological conditions, strength and persistence of memory must be regulated in order to produce behavioral flexibility. In fact, impairments in memory flexibility are associated with pathologies such as post-traumatic stress disorder or autism; however, the underlying mechanisms that enable memory flexibility are still poorly understood. Here, we identify transcriptional repressor Wilm’s Tumor 1 (WT1) as a critical synaptic plasticity regulator that decreases memory strength, promoting memory flexibility. WT1 is activated in the hippocampus following induction of long-term potentiation (LTP) or learning. WT1 knockdown enhances CA1 neuronal excitability, LTP and long-term memory whereas its overexpression weakens memory retention. Moreover, forebrain WT1-deficient mice show deficits in both reversal, sequential learning tasks and contextual fear extinction, exhibiting impaired memory flexibility. We conclude that WT1 limits memory strength or promotes memory weakening, thus enabling memory flexibility, a process that is critical for learning from new experiences., Impairments in memory flexibility are associated with neuropsychiatric disorders such as PTSD and autism. Here, the authors report that the transcriptional repressor Wilm's Tumor 1 regulates synaptic plasticity leading to weakening of memory strength and enabling memory flexibility.

Published
2019

37. P094 Transcriptomic and small RNA sequencing profile in ileal resections from complicated Crohn′s Disease patients

Author

M Seco-Cervera, C Bauset, C Santana-Plata, M Civera-Barrachina, D Ortiz-Masià, S Calatayud, and M D Barrachina

Subjects
Gastroenterology, General Medicine
Abstract

Background Crohn′s disease is a chronic inflammatory disorder of gastrointestinal tract that is classified into three different behaviours: the inflammatory (B1), the stenotic (B2) or the penetrating (B3). We pretend to identify differences in transcriptomic and non-long coding RNA expression profiles associated to damaged and no-damaged surgical ileal resections from complicated CD patients. Methods We conducted both RNA and small RNA sequencing profiling on ileal surgical resections from CD patients with structuring (n=10) or penetrating (n=10) behaviour; from each patient we obtained a sample from affected tissue (B2A and B3A, respectively) and the paired non-affected ileum (B2C and B3C, respectively). Ten ileal resections (control samples) were obtained from non-affected ileum of patients with right colorectal cancer (IL). Enrichment scores of the GO terms and KEGG pathways were used to functional analysis investigated in this study. Gene expression and miRNA profiles were validated by RT-qPCR. Results Our comparative bioinformatic analysis of RNA sequencing showed that the comparation of IL and the non-affected ileum from CD patients (B2C+B3C) revealed that only 11 genes were significantly altered and any miRNA with significative expression. The comparative analysis between B2A+B3A vs B2C+B3C showed: a) 2562 genes differentially regulated and the GO enrichment analysis determined that inflammation, cell activation, and regulation of the extracellular matrix (EM) were the main biological processes altered (Figure 1a). KEGG analysis showed that cytokine-receptor interaction and MAPK and Ras signalling were the most affected pathways (Figure 1b). Among the top ten up-regulated genes we found several immunoglobulins (such as IGHG4, IGHG3, and IGHG1), proteins of the extracellular matrix EM (such as EPYC, COMP, and CHI3L1), and transcription factors (such as PRRX1). When the analysis was performed by CD behaviour, results revealed that most of these genes were significantly increased in both, B2 and B3 CD; b) 103 miRNAs with differential expression, 56 were up-regulated and 47 were down-regulated. Negative and significant correlations were detected between the RNA expression of ECM components and some miRNA expression. Figure 1. Bar plot of enrichment analysis with differential expressed genes between B2A+B3A vs B2C+B3C. A) Biological Process (BP), Cellular Component (CC), and Molecular Function (MF) of Gene Ontology (GO) enrichment analysis. B) Enrichment of Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. Conclusion The correlation detected between extracellular matrix components and some miRNA suggest an epigenetic regulation in the affected ileum of complicated CD patients.

Published
2022
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38. P106 Macrophages as a source of NOTCH Ligands in Crohn’s disease: implications in fibrosis

Author

M M Edo, D C Macias-Ceja, C Bauset, L Lis, S Coll, M Seco-Cervera, J Cosin-Roger, S Calatayud, M D Barrachina, and D Ortiz-Masiá

Subjects
Gastroenterology, General Medicine
Abstract

Background Fibrosis constitute the main complications associated to Crohn′s disease (CD). NOTCH signalling has been implicated in lung, kidney, liver and cardiac fibrosis. Macrophages contribute to fibrosis through the release of different mediators and the pattern of secretion may vary according to their microenvironment. The aim of the present study is to analyze the role of NOTCH ligands derived from macrophages in the complications of CD. Methods The aim of the present study is to analyze the role of NOTCH ligands derived from macrophages in the complications of CD. We have analyzed: the protein expression of NOTCH ligands and receptors in CD patients with fistulizing (B3) and stenting pattern (B2), the protein expression of NOTCH ligands in macrophages treated with the main cytokines present in CD patients (IFNγ-, IL10-, IL4, TNFα-U937 treated cells), the protein expression of HES1 and fibrosis markers in DLL4-HT29 and DLL3-HT29 treated cells. Results are expressed as fold induction (mean±SEM). Statistical analysis was performed with one-way ANOVA followed by Newman-Keuls test or t-tet. Results The expression of DLL4 and NOTCH4 were significantly higher in intestinal samples from B3 CD patients (3,2 ± 0,6 N=4* and 3,8 ± 0,6 N=8*, respectively) than in B2 patients (1,6 ± 0,2 N=4 and 1,7 ± 0,3 N=8, respectively) and controls (1,0 ± 0,1N=3 and 1,0 ± 0,1 N=8, respectively). IFNγ-U937 treated cells increased significantly the protein expression of DLL3 and DLL4 (1,6 ± 0,09 N=6* and 1,3 ± 0,1 N=7*, respectively) respect vehicle; IL4 increased significantly the expression of DLL4 (1,4 ± 0,1 N=7*) and TNFα increased significantly the expression of DLL3 (1,4 ± 0,1 N=5*), respect vehicle. DLL4-HT29 treated cells increased significantly fibrosis markers (VIMENTIN: 1,7 ± 0,1 N=3*; SNAIL: 2,2 ± 0,2 N=3*) and HES1 (1,4 ± 0,06 N=3*), respect vehicle (1,0 ± 0,07 N=6; 1,0 ± 0,05 N=6; and 1,0 ± 0,05 N=6, respectively). DLL3-HT29 treated cells only produced a reduction in the protein expression of ECADHERIN (0,4 ± 0,1 N=3*), respect vehicle (1,0 ± 0,09 N=6). Conclusion Macrophages may act as a source of NOTCH ligands who could act as fibrosis mediators in CD patients with a fistulizing (B3) behavior. The microenvironment rich in IFNγ could activate the fibrosis process in epithelial cells by favoring the expression of DLL4 and DLL3 in macrophages. DLL4 mainly activates transcription factors involved in mesenchymal epithelial transition in colonic epithelial cells (SNAIL), while DLL3 seems to have a more relevant role in cell-cell junction modification (ECADHERIN).

Published
2022
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39. P051 IFNγ-macrophages could mediate EMT in Crohn’s disease through the WNT pathway

Author

M M Edo, D C Macias-Ceja, C Bauset, L Lis-Lopez, S Coll, M Seco-Cervera, J Cosin-Roger, S Calatayud, M D Barrachina, and D Ortiz-Masiá

Subjects
Gastroenterology, General Medicine, digestive system diseases
Abstract

Background Macrophages contribute to fibrosis by releasing different mediators and the pattern of secretion may vary depending on the surrounding environment. We previously described that the mRNA expression of IFNγ was significantly higher in intestinal samples from CD patients. Methods The aim of the present study is to analyze the role of IFNγ-treated macrophages in epithelial mesenchymal transition (EMT) through the WNT pathway. The mRNA and protein expression of IFNγ in surgical resections from Crohn′s disease. U937 were differentiated to macrophages and then treated with IFNγ (10 ng/ml) for 4 days, the mRNA expression of WNT2b, WNT6 and TGFβ were determined by RT-PCR and protein. IFNγ-U937 were coculture with HT29 cells for 3 days and the expression of EMT markers, βCATENIN and WNT2b in HT29 cells were analyzed by WB. In some cases, HT29 cells were treated with the inhibitor of the WNT-pathway, XAV939 (1 μM), or were transfected with vectors-targeting human FZD4 (miFzd4). Results are expressed as mean±SEM. Statistical analysis was performed by ANOVA + Newman-Keuls or unpaired t-test. Results The mRNA and protein expression of IFNγ were significantly higher in intestinal samples from B2 CD patients (11.4±1.6 fold induction and 70,0 ± 2,3 pg/mg, respectively) and B3 CD patients (14.2±1.8 fold induction and 80,4 ± 6,8 pg/mg, respectively) than in controls (1,0±0,1 fold induction and 18,9 ± 0,3 pg/mg, respectively). U937 cells treated with IFNγ increased significantly the protein expression of WNT2b (1,3 ± 0,07 N=13* vs vehicle) but not the expression of WNT6 or TGFβ. IFNγ-U937 co-cultured with HT29 increased significantly the protein expression of EMT markers, βCATENIN and WNT2b in HT29 cells (VIMENTIN: 2,7 ± 0,3 N=6* vs vehicle-HT29; SNAIL1: 1,5 ± 0,1 N=5* vs vehicle-HT29; βCATENIN: 1,4 ± 0,09 N=5* vs vehicle-HT29; WNT2b: 2,0 ± 0,3 N=8* vs vehicle-HT29). Treatment HT29 cells with XAV939 (VIMENTIN: 1,4 ± 0,4 N=6 vs vehicle-HT29 XAV; SNAIL1: 1,0 ± 0,1 N=5 vs vehicle-HT29 XAV; βCATENIN: 0,8 ± 0,1 N=5 vs vehicle-HT29 XAV) or with miFzd4 (VIMENTIN: 0,3 ± 0,07 N=12* vs IFNγ-HT29 mock; SNAIL1: 0,5 ± 0,06 N=12* vs IFNγ-HT29 mock; βCATENIN: 0,6 ± 0,04 N=12* vs IFNγ-HT29 mock; FZD4: 0,5 ± 0,04 N=12* vs IFNγ-HT29 mock) partially reversed the increases produced by IFNγ-U937 in HT29 cells. Conclusion IFNγ-macrophages may stimulate the expression of WNT ligands in an autocrine and paracrine manner. The expression of WNT ligands at the epithelial level could favor mesenchymal epithelial transition through WNT2b ligand and FZD4 receptor.

Published
2022
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40. Synthesis, Structural Features and Physical Properties of a Family of Triply Bridged Dinuclear 3d-4f Complexes

Author

Eider San Sebastian, Enrique Colacio, José M. Seco, Antonio Rodríguez-Diéguez, Itziar Oyarzabal, and Estitxu Echenique-Errandonea

Subjects
Materials science, Metal ions in aqueous solution, molecular magnetism, Ethylenediamine, Magneto-caloric effect, Ion, lcsh:Chemistry, Metal, chemistry.chemical_compound, lanthanide(III) metal ions, Materials Chemistry, Molecular magnetism, Coupling constant, magneto-caloric effect, Ligand, Electronic, Optical and Magnetic Materials, Lanthanide(III) metal ions, Crystallography, lcsh:QD1-999, Ferromagnetism, chemistry, Chemistry (miscellaneous), visual_art, transition metal ions, visual_art.visual_art_medium, Transition metal ions, Density functional theory
Abstract

New dinuclear MII-LnIII complexes of general formulas [Cu(µ-L)(µ-OAc)Ln(NO3 )2 ]·CH3CN· H2O (LnIII = Gd (1), Tb (2), Dy (3) and Er (4)), [Ni(CH3CN)(µ-L)(µ-OAc)Ln(NO3 )2 ]·CH3CN (LnIII = Nd (5), Gd (6), Tb (7), Dy (8), Er (9) and Y (10)) and [Co(CH3CN)(µ-L)(µ-OAc)Ln(NO3 )2 ]·CH3CN (LnIII = Gd (11), Tb (12), Dy (13), Er (14) and Y (15)) were prepared from the compartmental ligand N,N0 -dimethyl-N,N0 -bis(2-hydroxy-3-formyl-5-bromo-benzyl)ethylenediamine (H2L). In all these complexes, the transition metal ions occupy the internal N2O2 coordination site of the ligand, whereas the LnIII ions lie in the O4 external site. Both metallic ions are connected by an acetate bridge, giving rise to triple mixed diphenoxido/acetate bridged MIILnIII compounds. Direct current (dc) magnetic measurements allow the study of the magnetic exchange interactions between the 3d and 4f metal ions, which is supported by density functional theory (DFT) theoretical calculations for the GdIII - based counterparts. Due to the weak ferromagnetic exchange coupling constants obtained both experimentally and theoretically, the magneto-thermal properties of the less anisotropic systems (compounds 1 and 6) are also studied. Alternating current (ac)magnetic measurements reveal the occurrence of slight frequency dependency of the out-of-phase signal for complexes 8, 9 and 13, while complex 15 displays well-defined maximums below ~6 K., Junta de Andalucía (FQM-195 and the projects of excellence P11-FQM-7756 and A-FQM-172-UGR18), MINECO of Spain (Projects CTQ2014-56312-P and PGC2018-102052-B-C21), University of Granada, University of The Basque Country UPV/EHU (Project GIU14/01)

Published
2021
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41. Modulating Magnetic and Photoluminescence Properties in 2-Aminonicotinate-Based Bifunctional Coordination Polymers by Merging 3d Metal Ions

Author

Luis Lezama, José M. Seco, Enrique Colacio, José Ángel García, Eider San Sebastian, Oier Pajuelo-Corral, Andoni Zabala-Lekuona, Javier Cepeda, and Antonio Rodríguez-Diéguez

Subjects
Aqueous solution, 010405 organic chemistry, Metal ions in aqueous solution, Organic Chemistry, Supramolecular chemistry, General Chemistry, 010402 general chemistry, 01 natural sciences, Catalysis, 0104 chemical sciences, chemistry.chemical_compound, Crystallography, Magnetic anisotropy, chemistry, Diamagnetism, Antiferromagnetism, Isostructural, Bifunctional
Abstract

Herein, the synthesis and study of bifunctional coordination polymers (CPs) with both magnetic and photoluminescence properties, derived from a heterometallic environment, are reported. As a starting point, three isostructural monometallic CPs with the formula [M(μ-2ani)2 ]n (MII =Mn (1Mn ), Co (3Co ) and Ni (4Ni ); 2ani=2-aminonicotinate), crystallise as chiral 2D-layered structures stacked by means of supramolecular interactions. These compounds show high thermal stability in the solid state (above 350 °C), despite which, in aqueous solution, compound 1Mn is shown to partially transform into a novel 1D chain CP with the formula [Mn(2ani)2 (μ-H2 O)2 ]n (2Mn ). A study of the direct current (dc) magnetic properties of 1Mn , 3Co and 4Ni reveals a spin-canted structure derived from antisymmetric antiferromagnetic weak exchanges along the chiral network (as confirmed by DFT calculations) and magnetic anisotropy of the ions, in such a way that long-range ordering is observed with variable magnitude for the spin carriers. Moreover, compounds 3Co and 4Ni show no frequency-dependent alternating current (ac) susceptibility curves under zero dc field; this is characteristic behaviour of a glassy state that may be partially supressed for 3Co by applying an external dc field. To overcome long-range magnetic ordering, CoII ions are diluted in a diamagnetic ZnII -based matrix, which enables single-molecule magnet behaviour. Interestingly, this strategy allows a bifunctional Cox Zn1-x 2ani material, which is imbued with a strong photoluminescent emitting capacity, as characterised by an intense blue light followed by a green afterglow, to be obtained.

Published
2020

42. Alkaline-earth and aminonicotinate based coordination polymers with combined fluorescence/long-lasting phosphorescence and metal ion sensing response

Author

Antonio Rodríguez-Diéguez, Javier Cepeda, José M. Seco, José Ángel García, Sonia Pérez-Yáñez, Garikoitz Beobide, Oier Pajuelo-Corral, and Eider San Sebastian

Subjects
Alkaline earth metal, Materials science, Quenching (fluorescence), Photoluminescence, Metal ions in aqueous solution, 02 engineering and technology, General Chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, Metal, visual_art, Materials Chemistry, visual_art.visual_art_medium, Physical chemistry, Molecule, 0210 nano-technology, Phosphorescence, Luminescence
Abstract

Six novel coordination polymers (CPs) based on alkaline-earth (AE) metal ions and two sorts of aminonicotinate ligands, namely [M(μ-2ani)(μ3-2ani)(μ-DMF)]n [MII = Sr (1) and Ba (2)], {[M(μ-6ani)2(H2O)2]·3H2O}n [MII = Ca (3) and Sr (4)], {[Ca(μ-6ani)2(H2O)2]}n (5) and {[Ba(6ani)2(H2O)3]·7H2O}n (6) [where 2ani = 2-aminonicotinate and 6ani = 6-aminonicotinate] have been synthesized and well characterized. All compounds are firstly built up with AE-carboxylate infinite rods that provide compact 2D-layered structures in 1 and 2 but open architectures containing microchannels in an AE-6ani system. Interestingly, the architecture of 3 behaves as a flexible platform which undergoes spontaneous dehydration to yield compound 5. Structural transition occurring from 3 to 5 has been supported by periodic density functional theory (DFT) calculations and X-ray diffraction data. In this regard, compound 6 contains a high amount of solvent molecules which suggests the existence of pores in its structure. A deep study of the optical properties including a detailed experimental characterization and DFT based computational calculations of these compounds supports a fascinating photoluminescence performance which entails a bright blue emission accompanied by persistent green afterglows at low temperature, especially for compound 5 as reflected by its lifetime (τ ≈ 1.4 s). In addition to its strong room temperature emission properties, we took advantage of the open yet stable structure of compound 4, to check its viability as a new material sensitive to the presence of solvents and/or transition metal ions, via significant quenching of the luminescence of 4. Remarkably, 4 is shown to be a particularly efficient sensor for some water soluble pollutants.

Published
2019
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43. (Diphenylphosphino)alkylaldehyde affords hydride- or alkyl-[(diphenylphosphino)alkylacyl]rhodium(<scp>iii</scp>) or (diphenylphosphino)alkylester complexes: theoretical and experimental diastereoselectivity

Author

Susan Azpeitia, María A. Garralda, Lourdes Ibarlucea, José M. Seco, Miguel A. Huertos, Montserrat Barquín, Claudio Mendicute-Fierro, Antonio Rodríguez-Diéguez, and Eider San Sebastian

Subjects
chemistry.chemical_classification, Chloroform, 010405 organic chemistry, Hydride, Diastereomer, Cationic polymerization, chemistry.chemical_element, 010402 general chemistry, 01 natural sciences, Aldehyde, Oxidative addition, Medicinal chemistry, 0104 chemical sciences, Rhodium, Inorganic Chemistry, chemistry.chemical_compound, chemistry, Pyridine
Abstract

The reaction of [RhCl(COD)]2 (COD = 1,5-cyclooctadiene) with racemic PPh2(CH(Ph)CH2CHO) and pyridine (py) led to the oxidative addition of the aldehyde, and a single geometric isomer of [RhHCl(PPh2(CH(Ph)CH2CO))(py)2] (1), with hydride trans to chloride, was obtained as a mixture of two diastereomers in a 95 : 5 ratio; this was in agreement with density functional theory (DFT) calculations. In a chloroform solution, the exchange of hydride by chloride yielded [RhCl2(PPh2(CH(Ph)CH2CO))(py)2] (2) as a mixture of a kinetically preferred species, trans-py-2a, and two diastereomers, cis-Cl-2b' and cis-Cl-2b, with cis pyridines and a chloride trans to acyl; as predicted by the DFT calculations, the latter was the major species. Complex 1 reacted with racemic PPh2(CH(Ph)CH2CHO) or PPh2(o-C6H4CHO) to afford [RhHCl(PPh2(CH(Ph)CH2CO))(κ1-PPh2(CH(Ph)CH2CHO))(py)] (3) or [RhHCl(PPh2(o-C6H4CO))(κ1-PPh2(CH(Ph)CH2CHO))(py)] (4), respectively, both with a dangling alkylaldehyde. Diastereomeric mixtures with the ratios 3a/3a' = 80 : 20 and 4a/4a' = 50 : 50 were obtained. Complex 4 reacted with N-donors to afford cationic [RhH(NN)(PPh2(o-C6H4CO))(κ1-PPh2(CH(Ph)CH2CHO))]BPh4 (NN = 1,10-phenanthroline, 5; 2,2'-bipyridine, 6) or with 8-aminoquinoline (aqui) or 2-(aminomethyl)pyridine to yield imination products with terdentate ligands: [RhH(PPh2(o-C6H4CO))(κ3-PNN)]BF4 (PNN = PPh2(CH(Ph)CH2CNC9H6N), 7 and PPh2(CH(Ph)CH2CNCH2C5H4N), 8, respectively. Compounds 5-8 were obtained as equimolar a/a' mixtures of diastereomers. Moreover, 5a and 5a' could be separated. [RhCl(NBD)]2 reacted with racemic PPh2(CH(Ph)CH2CHO) and N-donors to provide nortricyclyl (Ntyl) derivatives [RhCl(NN)(Ntyl)(PPh2CH(Ph)CH2CO)] (NN = phen, 9 and bipy, 10) as an a/a' = 75 : 25 mixture of diastereomers. By reacting [RhCl(NBD)]2 with PPh2(CH(Ph)CH2CHO) and quinoline-8-carbaldehyde in methanol, the phosphino-ester complex [RhCl(Ntyl)(C9H6NCO)(κ2-PPh2CH(Ph)CH2CO(OCH3)] 11 was obtained. The initial equimolar mixture of two diastereomers readily transformed into a single diastereomer, which was found to be thermodynamically most stable by the DFT calculations. Furthermore, single crystal X-ray diffraction analysis of cis-Cl-2b, 5a, 7a, 10a and 11 is reported.

Published
2019
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44. Effect of the change of the ancillary carboxylate bridging ligand on the SMM and luminescence properties of a series of carboxylate-diphenoxido triply bridged dinuclear ZnLn and tetranuclear Zn2Ln2 complexes (Ln = Dy, Er)

Author

Javier Cepeda, Itziar Oyarzabal, José M. Seco, Antonio Rodríguez-Diéguez, Estitxu Echenique-Errandonea, Enrique Colacio, and Andoni Zabala-Lekuona

Subjects
chemistry.chemical_classification, Lanthanide, 010405 organic chemistry, Ligand, Bridging ligand, Ethylenediamine, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences, Inorganic Chemistry, chemistry.chemical_compound, Crystallography, chemistry, Carboxylate, Bridged compounds, Luminescence, Acetonitrile
Abstract

Eleven new dinuclear and tetranuclear compounds of general formulae [Zn(μ-L)(μ-X)Ln(NO3)2]·nS, [Zn2Dy2(μ3-L′)2(μ-sal)2(NO3)(CH3OH)](NO3)·5CH3OH and [Zn2Er2(μ3-L′)2(μ-sal)2(CH3OH)2](NO3)2·4CH3OH (X = benzoate, anthracenate, diclofenac, salicylate, 2,6-dihydroxybenzoate; Ln = Dy, Er; S = water, acetonitrile, methanol) were prepared from the N,N′-dimethyl-N,N′-bis(2-hydroxy-3-formyl-5-bromobenzyl)ethylenediamine compartmental ligand (H2L). Complexes 1–6 and 9–11 consist of diphenoxido-carboxylate triply bridged compounds, which differ mainly in the carboxylate bridging ligand. It should be noted that the acidic character of the salicylic acid promotes, in the presence of methanol, the methoxylation of the H2L ligand thereby yielding a hemiacetal H3L′, which is able to connect the Ln(III) ions of two ZnLn dinuclear units forming the Zn2Ln2 tetranuclear complexes 7 and 8. All compounds display SMM behaviour in the presence of an external field with effective energy barriers (Ueff) as high as 61 K. Magneto-structural data for these complexes reveal that their SMM behaviour is not only significantly affected by the type of Ln(III) ion but also by the carboxylate bridging ligand connecting the Zn(II) and Ln(III) ions. Photoluminescence properties have also been accomplished, showing that the ligands are able to sensitize lanthanide centred emissions in the visible and near-infrared regions with variable capacity. Moreover, the analysis of the luminescence decay curves reveals emission lifetimes in the range of few microsecond or hundreds of nanoseconds for Dy(III)-based or Er(III)-based luminophores, respectively.

Published
2019
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45. Photoluminescence and in vitro cytotoxicity analysis in a novel mononuclear Zn(II) coordination compound based on bumetanide

Author

José M. Méndez-Arriaga, Antonio Rodríguez-Diéguez, Alfonso Salinas-Castillo, Manuel Sánchez-Moreno, Estitxu Echenique-Errandonea, Javier Cepeda, José M. Seco, Amalia García-García, Duane Choquesillo-Lazarte, Ministerio de Economía y Competitividad (España), European Commission, and Universidad del País Vasco

Subjects
chemistry.chemical_classification, Photoluminescence, 010405 organic chemistry, Hydrogen bond, Ligand, Intermolecular force, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences, Coordination complex, Inorganic Chemistry, Crystallography, chemistry.chemical_compound, Monomer, chemistry, Materials Chemistry, medicine, Physical and Theoretical Chemistry, Single crystal, Bumetanide, medicine.drug
Abstract

A novel coordination compound based on Zn(II) and bumetanide (Hbum) of general formulae [Zn(bum)(HO)]·2HO has been synthesized and fully characterized by elemental analyses and single crystal X-ray diffraction. The results indicate that compound 1 possesses a monomeric structure in which the main intermolecular interactions stabilizing the structure are hydrogen bonds. Due to the fully filled d orbitals of Zn(II), this coordination compound could be an ideal candidate to show strong emission. That is the reason why, photoluminescence properties have been studied showing that this compound presents ligand derived emission ruled by ligand-centred π-π* electronic transitions. Additionally, because of the well-recognised therapeutic properties of bumetanide, antiparasitic efficacy against three leishmania spp. strains has been studied for the corresponding ligand and coordination compound., This work has been funded by Junta de Andalucía (FQM-394), the Spanish Ministry of Economy and Competitiveness (MCIU/AEI/FEDER, UE) (PGC2018-102052-A-C22, PGC2018-102052-B-C21 and PGC2018-102047-B-I00), Red Guipuzcoana de Ciencia, Tecnología e Innovación (OF188/2017), University of the Basque Country (GIU 17/13). E.E. is grateful to the Government of the Basque Country for the predoctoral fellowship. The authors thank for technical and human support provided by SGIker of UPV/EHU and European funding (ERDF and ESF).

Published
2020

46. Bacillus subtilis RarA modulates replication restart

Author

Elena M. Seco, Silvia Ayora, Begoña Carrasco, María López-Sanz, and Juan C. Alonso

Subjects
0301 basic medicine, DNA Replication, DNA, Bacterial, Models, Molecular, ATPase, DNA, Single-Stranded, Bacillus subtilis, Biology, Genome Integrity, Repair and Replication, Substrate Specificity, 03 medical and health sciences, chemistry.chemical_compound, Bacterial Proteins, Protein Domains, Genetics, Adenosine Triphosphatases, DNA replication, DNA Helicases, Helicase, DNA, biology.organism_classification, Cell biology, DNA-Binding Proteins, 030104 developmental biology, chemistry, Retinoic acid receptor alpha, biology.protein, Nucleic Acid Conformation, Function (biology), Recombination, Genome, Bacterial, Protein Binding
Abstract

The ubiquitous RarA/Mgs1/WRNIP protein plays a crucial, but poorly understood role in genome maintenance. We show that Bacillus subtilis RarA, in the apo form, preferentially binds single-stranded (ss) over double-stranded (ds) DNA. SsbA bound to ssDNA loads RarA, and for such recruitment the amphipathic C-terminal domain of SsbA is required. RarA is a DNA-dependent ATPase strongly stimulated by ssDNA–dsDNA junctions and SsbA, or by dsDNA ends. RarA, which may interact with PriA, does not stimulate PriA DNA unwinding. In a reconstituted PriA-dependent DNA replication system, RarA inhibited initiation, but not chain elongation. The RarA effect was not observed in the absence of SsbA, or when the host-encoded preprimosome and the DNA helicase are replaced by proteins from the SPP1 phage with similar function. We propose that RarA assembles at blocked forks to maintain genome integrity. Through its interaction with SsbA and with a preprimosomal component, RarA might impede the assembly of the replicative helicase, to prevent that recombination intermediates contribute to pathological DNA replication restart.

Published
2018

47. Coordination Polymers with Intriguing Photoluminescence Behavior: The Promising Avenue for Greatest Long‐Lasting Phosphors

Author

Antonio Rodríguez-Diéguez, José M. Seco, Eider San Sebastian, and Javier Cepeda

Subjects
chemistry.chemical_classification, Long lasting, Photoluminescence, Phosphor, Nanotechnology, 02 engineering and technology, Polymer, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, Afterglow, Inorganic Chemistry, chemistry, Metal-organic framework, 0210 nano-technology, Luminescence
Published
2018
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48. P088 Metabolomic analysis reveals differences among UC and non-IBD human colonic resections: role of GPCRs

Author

C Bauset, M Carda-Diéguez, E Buetas, S Coll, L Lis-López, M Seco-Cervera, F Navarro, Á Mira, S Calatayud, M D Barrachina, and J Cosín-Roger

Subjects
Gastroenterology, General Medicine
Abstract

Background Metabolomics is a recent technique that has bounced into Inflammatory Bowel Diseases (IBD) due to its capacity to elucidate specific metabolites involved in the pathology and changes in the metabolomic profile have been detected in urine, blood or feces from UC patients. G-protein coupled receptors (GPCRs) have been recently identified as promising pharmacological targets. We aim to characterize the metabolomic profile and metabolite-sensing GPCRs expression in colonic resections from UC patients. Methods Colonic resections from UC (n=18) and non-IBD (n=20) patients were obtained. Metabolomic analysis was performed using Nuclear Magnetic Resonance (NMR) to study polar metabolites and Gas-Chromatography or Liquid-Chromatography Mass-Spectrometry to study non-polar metabolites. Results are expressed as μg of metabolite per gram of tissue. Gene expression of GPCRs was analyzed by qPCR. Data were expressed as fold induction vs control (mean±SEM) and compared by a t-test. A p-value Results Metabolomic analysis revealed in colon of UC patients significant increased levels of propionic acid (7.7±1.1), undecanoic acid (0.3±0.02) decanoic acid (4.5±0.9), myristic acid (64.5±8.7), α-linoleic acid (23.1±4.0), aspartic acid (33.9±3.4), phenylalanine (8.8±1.6), glutamic acid, (136.3±10.8), b-hydroxybutyric (8.3±0.9) acid and lactic acid (297.5±34.7) vs non-IBD patients. Gene expression of GPR43 (22.7±9.5), GPR41 (4.7±1.7), GPR109a (19.1±5.3), GPR109b (13.6±4.6), GPR91 (13.2±5.7), GPR84 (6.7±2.0), GPR40 (6.6±1.8), GPR65 (3.0±0.5) and GPR68 (4.6±1.0) were significantly increased in UC patients compared with controls. In contrast, GPR120 (0.9±0.3), GPR119 (0.6±0.2) and GPR35 (0.5±0.1) were significantly reduced in UC patients. N-oleylethanolamide positively correlates with most of GPCRs, especially GPR68, GPR84 and GPR91 while acetic and succinic acids negatively correlate with GPR4 (Fig.1A). In UC patients, medium-chain fatty acids (FA) and most long-chain FA positively correlate with GPR84, GPR142, GPR43, GPR109a, GPR109b, GPR91 and GPR132 (Fig. 1C). Fig1. Graphs show the correlations between data relative to mRNA expression of GPCRs (expressed as ΔCt) vs metabolites. (A) Data from controls and UC. (B) Only controls. (C) Only UC. Conclusion Increased levels of several metabolites and GPCRs are detected in the colon of UC patients and their correlations suggest potential candidates to be involved in UC pathophysiology.

Published
2022
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49. Slow relaxation of magnetization and luminescence properties of a novel dysprosium and pyrene-1,3,6,8-tetrasulfonate based MOF

Author

Antonio A. García-Valdivia, Duane Choquesillo-Lazarte, José M. Seco, Itziar Oyarzabal, Alfonso Salinas-Castillo, Santiago Gómez-Ruiz, Antonio Rodríguez-Diéguez, Javier Cepeda, and Amalia García-García

Subjects
Photoluminescence, 010405 organic chemistry, Ligand, Relaxation (NMR), chemistry.chemical_element, General Chemistry, 010402 general chemistry, 01 natural sciences, Catalysis, Hydrothermal circulation, 0104 chemical sciences, Magnetization, chemistry.chemical_compound, Nuclear magnetic resonance, chemistry, Materials Chemistry, Dysprosium, Pyrene, Physical chemistry, Luminescence
Abstract

We report the formation of a novel multifunctional metal–organic framework (MOF) based on dysprosium(III) ions using pyrene-1,3,6,8-tetrasulfonate (pytet)4− as a ligand, synthesized using a soft hydrothermal route. This material shows a two-dimensional network with small channels along a crystallographic axis and displays intense photoluminescence properties in the solid state at room temperature due to the pyrene derivative ligand. The magnetic properties of this 2D-MOF are also accomplished, confirming slightly frequency-dependent out of phase signals under an applied field of 1000 Oe.

Published
2018
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50. Modulation of pore shape and adsorption selectivity by ligand functionalization in a series of 'rob'-like flexible metal–organic frameworks

Author

David Fairen-Jimenez, Peyman Z. Moghadam, Manuel Pérez-Mendoza, Javier Cepeda, Nicola Casati, Antonio J. Calahorro, José M. Seco, Antonio Rodríguez-Diéguez, and Marta Aragones-Anglada

Subjects
Diffraction, Materials science, Renewable Energy, Sustainability and the Environment, Ligand, 02 engineering and technology, General Chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, Molecular sieve, 01 natural sciences, Synchrotron, 0104 chemical sciences, law.invention, Adsorption, Chemical engineering, law, Surface modification, General Materials Science, Metal-organic framework, 0210 nano-technology, Selectivity
Abstract

We report the synthesis of a new family of four new isoreticular metal–organic frameworks (MOFs) based on Cu–Cu paddle-wheel building units. The four MOFs contain 1D microchannels modulated by chemical functionalisation of a dicarboxylate ligand or the use of different bis-4,4′-pyridyl-like connectors behaving as ancillary linkers. A deep analysis of their CO2, H2 and CH4 adsorption properties, combining both experimental and grand canonical Monte Carlo isotherms as well as in situ synchrotron X-ray diffraction, shows variable adsorption behaviour towards the studied gases, with some materials acting as molecular sieves with virtually infinite selectivity.

Published
2018
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