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While metal nanoparticles are widely used, their small size makes them mechanically unstable. Extensive prior research has demonstrated that nanoparticles with sizes in the range of 10-50 nm fail by the surface nucleation of dislocations, which is a thermally activated process. Two different contributions have been suggested to cause the weakening of smaller particles: first, geometric effects such as increased surface curvature reduce the barrier for dislocation nucleation; second, surface diffusion happens faster on smaller particles, thus accelerating the formation of surface kinks which nucleate dislocations. These two factors are difficult to disentangle. Here we use in situ compression testing inside a transmission electron microscope to measure the strength and deformation behavior of platinum particles in three groups: 12 nm bare particles, 16 nm bare particles, and 12 nm silica-coated particles. Thermodynamics calculations show that, if surface diffusion were the dominant factor, the last two groups would show equal strengthening. Our experimental results refute this, instead demonstrating a 100% increase in mean yield strength with increased particle size and no statistically significant increase in strength due to the addition of a coating. A separate analysis of stable plastic flow corroborates the findings, showing an order-of-magnitude increase in the rate of dislocation nucleation with a change in particle size and no change with coating. Taken together, these results demonstrate that surface diffusion plays a far smaller role in the failure of nanoparticles by dislocations as compared to geometric factors that reduce the energy barrier for dislocation nucleation.

This study used a person-centred approach to consider profiles of parent-child sex communication. We sought to determine whether profiles of sex communication were distinguishable from one another based on aspects of both the parent and the child. Participants included 596 US young people (51% female at birth; Mage = 14.55, SD = 1.70, 56% white), and their mother (n = 596; Mage = 41.23, SD = 8.18; 64% white) and father (n = 354; Mage = 43.44, SD = 8.56; 62% white) figures. Analyses suggested three profiles of parent-child sex communication with mothers and four with fathers. Patterns were similar across profiles, with variation being primarily the degree to which parents reported timing, frequency and quality of communication. Parents who more strongly endorsed proactive and reactive parenting, and who reported more frequent and open conversations with their children were warmer and had higher levels of self-efficacy. They also had children who were more sexually active, but who had healthier sexual outcomes. Discussion focuses on the importance of considering multiple aspects of parent-child sex communication and highlights the importance of continuing to empower parents to discuss sex and sexuality with their children.

The designation of first-generation college students in educational research has been operationalized inconsistently since its inception. This variation makes understanding and generalizing about this complex group problematic. We explore the inconsistencies in definitions of first-generation students using a culture of college resilience framework and argue that substantial differences in these definitions exist across the literature, which scholars should consider when conducting research on first-generation students. The need for a more stringent definition of what constitutes a first-generation college student is discussed at length. We propose a familial educational capital model that centers on risk and protective factors across social class and familial education. We offer recommendations for researchers, administrators, and other key stakeholders to consider how to operationalize this diverse group more mindfully. Finally, we provide other recommendations to address educational inequalities more effectively for this group.

Molybdenum carbide has various applications for which studying the material using classical molecular dynamics simulations would be valuable. Here, we develop an empirical potential within the Tersoff formalism using particle swarm optimization for the orthorhombic phase of Mo2C. The developed potential is shown to predict lattice constants, elastic properties, and equation of state results that are consistent with current and previously reported results from experiments and first principles calculations. We demonstrate the potential with simulations of indentation using multiple indenter sizes that load and unload in three different directions relative to the crystallographic lattice of orthorhombic Mo2C. Direction-dependent force-displacement trends are analyzed and explained in terms of the spatial distributions of stress and strain within the material during indentation. This study reveals the anisotropic elasticity of orthorhombic Mo2C and, more generally, provides researchers with a new empirical potential that can be used to explore the properties and behavior of the material going forward.

Research on community engaged learning (CEL) courses predominantly focuses on the learning experiences of white students or quality of student-community partner relationship(s). Scholarship accounting for the learning experiences of minoritized students describes negative learning experiences wherein students' learning goals are subordinated to their role as peer educators. Given this literature, our case study of a CEL course yielding positive outcomes for immigrant students sought to identify promising pedagogical practices that support the diversity of CEL students. Through 13 student interviews, we identified distinct learning goals for immigrant versus nonimmigrant students. We also found distinct "hidden curricula" for both student groups, with immigrant students gaining empowerment and nonimmigrant students gaining deeper understanding of immigrant communities. Despite these differences, both groups described similar levels of commitment to their community partners. Many students also felt their service helped them find "common ground" across their diverse experiences, highlighting CEL's promise for teaching humility and understanding of difference.

The mechanical behavior of nanostructures is known to transition from a Hall-Petch-like "smaller-is-stronger" trend, explained by dislocation starvation, to an inverse Hall-Petch "smaller-is-weaker" trend, typically attributed to the effect of surface diffusion. Yet recent work on platinum nanowires demonstrated the persistence of the smaller-is-stronger behavior down to few-nanometer diameters. Here, we used in situ nanomechanical testing inside of a transmission electron microscope (TEM) to study the strength and deformation mechanisms of platinum nanoparticles, revealing the prominent and size-dependent role of surfaces. For larger particles with diameters from 41 nm down to approximately 9 nm, deformation was predominantly displacive yet still showed the smaller-is-weaker trend, suggesting a key role of surface curvature on dislocation nucleation. For particles below 9 nm, the weakening saturated to a constant value and particles deformed homogeneously, with shape recovery after load removal. Our high-resolution TEM videos revealed the role of surface atom migration in shape change during and after loading. During compression, the deformation was accommodated by atomic motion from lower-energy facets to higher-energy facets, which may indicate that it was governed by a confined-geometry equilibration; when the compression was removed, atom migration was reversed, and the original stress-free equilibrium shape was recovered.

Abstract Background In the U.S., employees often return to work within 8–12 weeks of giving birth, therefore, it is critical that workplaces provide support for employees combining breastfeeding and work. The Affordable Care Act requires any organization with more than 50 employees to provide a space other than a restroom to express breastmilk and a reasonable amount of time during the workday to do so. States and worksites differ in the implementation of ACA requirements and may or may not provide additional support for employees combining breastfeeding and work. The purpose of this study was to conduct an analysis of the policies and resources available at 26 institutions within a state university system to support breastfeeding when employees return to work after giving birth. Methods Survey data was collected from Well-being Liaisons in the human resources departments at each institution. In addition, we conducted a document review of policies and online materials at each institution. We used univariate statistics to summarize survey results and an inductive and deductive thematic analysis to analyze institutional resources available on websites and in policies provided by the liaisons. Results A total of 18 (65.3%) liaisons participated in the study and revealed an overall lack of familiarity with the policies in place and inconsistencies in the resources offered to breastfeeding employees across the university system. Only half of the participating liaisons reported a formal breastfeeding policy was in place on their campus. From the document review, six major themes were identified: placing the burden on employees, describing pregnancy or postpartum as a “disability,” having a university-specific policy, inclusion of break times for breastfeeding, supervisor responsibility, and information on lactation policies. Conclusion The review of each institution’s online resources confirmed the survey findings and highlighted the burden placed on employees to discover the available resources and advocate for their needs. This paper provides insight into how institutions support breastfeeding employees and provides implications on strategies to develop policies at universities to improve breastfeeding access for working parents.

While it is well established that nanoparticle shape can depend on equilibrium thermodynamics or growth kinetics, recent computational work has suggested the importance of thermal energy in controlling the distribution of shapes in populations of nanoparticles. Here, we used transmission electron microscopy to characterize the shapes of bare platinum nanoparticles and observed a strong dependence of shape distribution on particle size. Specifically, the smallest nanoparticles (

In finance, assuming more risk often corresponds to the expectation of higher, compensating returns. In this setting, alpha stands out as one of the most prevalent and refined measures of risk-adjusted return ever postulated, allowing for the estimation of the excess return that cannot be explained by the risk factors impacting an asset. This article introduces a neural network architecture designed to formulate an investment strategy with the explicit goal of maximizing alpha. The strategy, centered around market timing, determines on a daily basis, based on past returns of the risky asset, whether to fully invest in the risky asset or opt for the risk-free alternative. The neural network architecture comprises two components: a policy network for strategy implementation and an evaluation network for long-term alpha computation during parameter optimization. Employing value-weighted US size decile portfolios as risky assets, the study achieves significant out-of-sample alphas ranging from 3.6% to 8.2% per year under the $q^{5}$ asset pricing model (with a transaction cost assumption of one basis point). By construction, these alphas are not generated by risky asset growth. Robustness tests yield similar results with equal-weighted decile portfolios or under the Fama and French six-factor asset pricing model. Variations in transaction cost, number of past returns used as inputs, policy network design, or training sample size produce similar outcomes. This study underscores the effectiveness of reinforcement learning-inspired techniques in uncovering alpha in financial markets.

BackgroundEthnic-racial identity (ERI) development refers to how individuals’ experiences, beliefs, and attitudes influence understanding of ethnic-racial group membership. Messages about race, from multiple ecosystems, influence identity development and how individuals come to form their ERI. There has been a shift in ERI research to focus on Multiracial populations, however, most of the research focus is on Black/white biracial and general, non-specified Multiracial populations. The ERI development process and experience for persons of other Multiracial backgrounds (e.g., AfroLatinx or AsianBlack) is not as extensively studied. This systematic literature review aims to elucidate the existing conceptualization of Multiracial ERI development for non-Black/white biracial and general Multiracial populations in the United States.MethodsA comprehensive search strategy was employed across multiple academic databases to identify relevant studies based on explicit inclusion criteria. The initial search resulted in 1,846 articles, but when only Black/white biracial and non-specified general Multiracial studies were eliminated from this review, only 18 articles met the criteria for inclusion.ResultsCommon themes emerged from the reviewed literature, including the importance of spaces, conflicting social messages directed at Multiracial individuals, and coping responses used by Multiracial individuals when faced with challenges by family members and peers regarding their multiracial identity.DiscussionThe findings underscore the need for a more nuanced exploration of ERI development among diverse Multiracial populations. Understanding the unique strengths, experiences, and challenges of different Multiracial populations beyond the Black-white biracial paradigm is essential for understanding ERI development across and between different Multiracial populations in today’s world.

The mechanical behavior of nanoparticles governs their performance and stability in many applications. However, the small sizes of technologically relevant nanoparticles, with diameters in the range of 10 nm or less, significantly complicate experimental examination. These small nanoparticles are difficult to manipulate onto commercial test platforms and deform at loads that are below the typical noise floor of the testing instruments. Here, we synthesized small platinum nanoparticles directly onto a mechanical tester and used a modified nanomanipulator to enhance load resolution to the nanonewton scale. We demonstrated the in situ compression of an 11.5-nm platinum nanoparticle with simultaneous high-resolution measurements of load and particle morphology. Molecular dynamics simulations were performed on similarly sized particles to achieve complementary measurements of load and morphology, along with atomic resolution of dislocations. The experimental and simulation results revealed comparable values for the critical resolved shear stress for failure, 1.28 and 1.15 GPa, respectively. Overall, this investigation demonstrated the promise of, and some initial results from, the combination of atomistic simulations and in situ experiments with an unprecedented combination of high spatial resolution and high load resolution to understand the behavior of metal nanoparticles under compression.

Increasing salinization of groundwater used for irrigation is a current and growing problem for vegetable production in greenhouses in the Mediterranean Basin. Vegetable growers in this system require clear information of crop response to salinity, particularly of threshold values. For sweet pepper in Mediterranean greenhouses, this work (i) evaluated the effect of increasing salinity on various parameters of crop yield, fruit quality and plant water relations, and (ii) determined threshold and slope values for the Maas and Hoffman (M&H) model. Sweet pepper was grown with nutrient solutions (ns) with electrical conductivities (EC) of 2.5 (T1), 3.5 (T2), 4.5 (T3), 5.5 (T4), 6.5 (T5) and 7.5 (T6) dS m−1. There were substantial and statistically significant reductions in total and marketable yield, dry matter production (DMP) and average fruit weight, with increasing salinity. In treatment T4 (ns of 5.5 dS m−1), the respective reductions for these parameters, compared to T1 (ns of 2.5 dS m−1), were 37%, 37%, 47%, 52% and 30%. Applying the M&H model, soil solution EC threshold (ECsst) values for total and marketable yield were 4.8 and 5.0 dS m−1. The respective slope values were − 8.0 and − 12.0%/dS m−1. The more rapid decline in marketable yield was influenced by a large increase in the incidence of blossom end rot (BER) with increasing salinity. In treatment T1, 25% of discarded fruit had BER which increased to 70% in T6. Average fruit size was affected by salinity, but fruit number was not. Most fruit quality parameters were unaffected by increasing salinity. However, fruits were more red and more yellow. Leaf water potential (ΨW), leaf osmotic potential (ΨO), stomatal conductance (gS) and leaf turgor potential (ΨP) followed the Maas and Hoffman model, with ΨW, ΨO and gS declining and ΨP increasing after the EC threshold value. The ECsst value for ΨW was 5.0 dS m−1, and for ΨO, gS and ΨP was 5.6–5.8 dS m−1. Considering all data, an ECsst value of 5.0 dS m−1 is suggested for sweet pepper grown in Mediterranean greenhouses.

Understanding the size- and shape-dependent properties of platinum nanoparticles is critical for enabling the design of nanoparticle-based applications with optimal and potentially tunable functionality. Toward this goal, we evaluated nine different empirical potentials with the purpose of accurately modeling faceted platinum nanoparticles using molecular dynamics simulation. First, the potentials were evaluated by computing bulk and surface properties-surface energy, lattice constant, stiffness constants, and the equation of state-and comparing these to prior experimental measurements and quantum mechanics calculations. Then, the potentials were assessed in terms of the stability of cubic and icosahedral nanoparticles with faces in the {100} and {111} planes, respectively. Although none of the force fields predicts all the evaluated properties with perfect accuracy, one potential-the embedded atom method formalism with a specific parameter set-was identified as best able to model platinum in both bulk and nanoparticle forms.

The lack of empirically based diagnostic criteria for delayed ejaculation (DE) not only undermines confidence in the reported prevalence rates for this sexual dysfunction, but it has also resulted in a lack of validated patient reported outcomes (PROs) for assessing this condition. The current study was designed to describe and evaluate six face-valid variables previously shown to discriminate between men with and without DE for their utility as diagnostic measures for DE. A sample of 1285 men (mean age = 37.8, SD = 12.7) free of erectile problems and premature ejaculation completed an online sexual health survey that included potential questions intended for use in the diagnosis of DE. Questionnaire items included ones reflective of previously proposed diagnostic constructs related to DE: ejaculation timing/latency, ejaculation efficacy/control, and negative effects of DE. Results indicated that five of the six proposed items showed moderate intercorrelations, suggesting that each constituted a distinct (i.e., non-redundant) though relevant criterion related to the diagnosis of DE. Based on the level of interrelatedness, the better items representing each construct were included in commonality analysis to assess their unique contributions to the diagnosis of DE. Perceived lack of ejaculatory efficacy/control contributed the largest portion of the variance to the diagnosis of DE (58%), with bother/distress (an index of the negative effects of DE) contributing the second largest portion (25%), and ejaculation timing/latency contributing only a small portion of the variance (6%) to the diagnosis of DE. The relevance of these findings to developing a patient report outcome (PRO) for diagnosing DE that considers both empirically supported questions/items and an appropriate balance of items regarding the three constructs was discussed.

Abstract Sleep is a complex process and is needed both in health and illness. Deprivation of sleep is known to have multiple negative physiological effects on people’s bodies and minds. Despite the awareness of these harmful effects, previous studies have shown that sleep is poor among hospitalised patients. We utilized an observational design with 343 patients recruited from medical and surgical units in 12 hospitals located in nine Spanish regions. Sociodemographic and clinical characteristics of patients were collected. Sleep quality at admission and during hospitalisation was measured by the Pittsburgh Sleep Quality Index. Sleep quantity was self-reported by patients in hours and minutes. Mean PSQI score before and during hospitalisation were respectively 8.62 ± 4.49 and 11.31 ± 4.04. Also, inpatients slept about an hour less during their hospital stay. Lower educational level, sedative medication intake, and multi-morbidity was shown to be associated with poorer sleep quality during hospitalisation. A higher level of habitual physical activity has shown to correlate positively with sleep quality in hospital. Our study showed poor sleep quality and quantity of inpatients and a drastic deterioration of sleep in hospital versus at home. These results may be helpful in drawing attention to patients’ sleep in hospitals and encouraging interventions to improve sleep.

Abstract Background The detection of cancer in its early latent stages can improve patients’ chances of recovery and thereby reduce the overall burden of the disease. Our objectives were to investigate factors (geographic accessibility and deprivation level) affecting mammography screening participation variation and to determine how much geographic variation in participation rates can be explained by spillover effects between adjacent areas, while controlling for covariates. Methods Mammography screening participation rates between 2015 and 2016 were calculated by census blocks (CB), for women aged 50–74 years, residing in Lyon metropolitan area. Global spatial autocorrelation tests were applied to identify the geographic variation of participation. Spatial regression models were used to incorporate spatial structure to estimate associations between mammography participation rate and the combined effect (geographic accessibility and deprivation level) adjusting for modes of travel and social cohesion. Results The mammography participation rate was found to have a statistically significant and positive spatial correlation. The participation rate of one CB was significantly and positively associated with the participation rates of neighbouring CB. The participation was 53.2% in residential and rural areas and 46.6% in urban areas, p

Abstract The elastic behavior of nanoparticles depends strongly on particle shape, size, and crystallographic orientation. Many prior investigations have characterized the elastic modulus of nanoscale particles using experiments or simulations; however their reported values vary widely depending on the methods for measurement and calculation. To understand these discrepancies, we used classical molecular dynamics simulation to model the compression of platinum nanoparticles with two different polyhedral shapes and a range of sizes from 4 to 20 nm, loaded in two different crystal orientations. Multiple standard methods were used to calculate the elastic modulus from stress-vs-strain data for each nanoparticle. The magnitudes and particle-size dependence of the resulting moduli varied with calculation method and, even for larger nanoparticles where bulk-like behavior may be expected, the effective elastic modulus depended strongly on shape and orientation. Analysis of per-atom stress distributions indicated that the shape- and orientation-dependence arise due to stress triaxiality and inhomogeneity across the particle. When the effective elastic modulus was recalculated using a representative volume element in the center of a large nanoparticle, the elastic modulus had the expected value for each orientation and was shape independent. It is only for single-digit nanoparticles that meaningful differences emerged, where even the very center of the particle had a lower modulus due to the effect of the surface. These findings provide better understanding of the elastic properties of nanoparticles and disentangle geometric contributions (such as stress triaxiality and spatial inhomogeneity) from true changes in elastic properties of the nanoscale material.

This work relates to greenhouse vegetable production in soil in Almeria, Spain. The prescriptive–corrective management (PCM) of irrigation and fertilization (N, P, K, Ca, and Mg) was evaluated. PCM combined recommendations (prescriptive management) for irrigation and nutrients made with the VegSyst-DSS v2, a decision support system, with monitoring (corrective management) using tensiometers (for irrigation) and petiole sap analysis (for nutrients). PCM was compared with conventional farmer management (CONV). The VegSyst-DSS v2 recommends applied nutrient concentrations considering simulated crop uptake, available soil nutrient supply, and evapotranspiration (ETc). This study was conducted with soil-grown tomato in a plastic greenhouse. Nutrients were applied in nutrient solution via drip fertigation. Compared to CONV management, PCM reduced irrigation by 25%, N, K, and Mg application by 40%, Ca by 58%, and P by 85%. There were no significant differences between treatments in fruit production and quality, despite appreciable reductions in irrigation and nutrient application. An economic analysis indicated that in this 7-month tomato crop, PCM compared to CONV management was associated with a financial saving of 1611 € ha−1. These results showed that by using prescriptive–corrective fertigation management, based on the VegSyst-DSS v2, considerable savings can be achieved in water and nutrient (N, P, K, Ca, and Mg) inputs to greenhouse tomato without compromising production. This can reduce farmer costs and the environmental impact associated with these greenhouse production systems.

ABSTRACT Although parasite entry through breaks in the skin or mucosa is one of the main routes of natural transmission of Trypanosoma cruzi, little is known about the host cell types initially invaded nor the ability of those host cells to initiate immune responses at the site of infection. To gain insights into these early events, we studied the fate of fluorescently tagged T. cruzi delivered subcutaneously in mouse footpads or ears. We demonstrate that the majority of parasites introduced into the skin initially proliferate there until 8 to 10 days postinfection, when the parasite load decreases. This decline in parasite numbers is dependent on the presence of an intact T cell compartment and on the ability of hosts to produce gamma interferon (IFN-γ). Many of the parasite-containing cells at the initial infection site display a macrophage/monocyte phenotype but with low expression of activation markers, suggesting that these cells provide an early niche for T. cruzi proliferation, rather than being active in parasite control. It is only after the first round of T. cruzi replication and release from host cells that signs of immune activation and control of parasites become apparent. The delay in the activation and failure to rapidly control parasite replication are observed even when T. cruzi-primed T cells are present, such as in chronically infected mice. This failure of a primed immune system to recognize and react prior to extensive parasite expansion at the infection site likely poses a significant challenge for the development of vaccines aiming to prevent T. cruzi infection. IMPORTANCE Trypanosoma cruzi, the parasite causing Chagas disease, usually infects through the mucosa or breaks in the skin, but little is known about the parasite's fate at the site of entry or the early events involving immune control there. Here, we track the local proliferation and subsequent dissemination of fluorescently tagged T. cruzi and the initial immune response at the point of entry. We show that T. cruzi preferentially infects innate immune cells in the skin and that the stimulation of an adaptive T cell response does not occur until after the release of parasites from this first round of infected host cells. This first immunologically “silent” proliferation occurs even in the presence of a strong immune T cell memory generated by previous infection. This capacity of T. cruzi to establish infections while avoiding initial immune recognition has important implications for the potential to develop vaccines to prevent T. cruzi infection.

Trypanosoma cruzi naturally infects a wide variety of wild and domesticated mammals, in addition to humans. Depending on the infection dose and other factors, the acute infection can be life-threatening, and in all cases, the risk of chagasic heart disease is high in persistently infected hosts. Domestic, working, and semi-feral dogs in the Americas are at significant risk of T. cruzi infection and in certain settings in the southern United States, the risk of new infections can exceed 30% per year, even with the use of vector control protocols. In this study, we explored whether intermittent low-dose treatment with the trypanocidal compound benznidazole (BNZ) during the transmission season, could alter the number of new infections in dogs in an area of known, intense transmission pressure. Preliminary studies in mice suggested that twice-weekly administration of BNZ could prevent or truncate infections when parasites were delivered at the mid-point between BNZ doses. Pre-transmission season screening of 126 dogs identified 53 dogs (42.1%) as T. cruzi infection positive, based upon blood PCR and Luminex-based serology. Serial monitoring of the 67 uninfected dogs during the high transmission season (May to October) revealed 15 (22.4%) new infections, 6 in the untreated control group and 9 in the group receiving BNZ prophylaxis, indicating no impact of this prophylaxis regimen on the incidence of new infections. Although these studies suggest that rigorously timed and more potent dosing regimen may be needed to achieve an immediate benefit of prophylaxis, additional studies would be needed to determine if drug prophylaxis reduced disease severity despite this failure to prevent new infections.

The generally established protocol for leaf measurement with proximal optical sensors is to use the most recently fully expanded leaf. However, differences in the nitrogen (N) status of lower and upper leaves could possibly be used to enhance optical sensor measurement. Normalized indices that consider both upper and lower leaves have been proposed to improve the assessment of crop N status and yield estimation. This study evaluated whether normalized indices improved the estimation of crop yield from measurements with three different proximal optical sensors: (i) SPAD-502 leaf chlorophyll meter, (ii) Crop Circle ACS 470 canopy reflectance sensor, and (iii) Multiplex fluorescence meter. The study was conducted with sweet pepper (Capsicum annuum L.) and muskmelon (Cucumis melo L.) in plastic greenhouses in Almeria, Spain. Measurements were made on the latest (most recent) leaf (L1), and the second (L2), third (L3) and fourth (L4) fully expanded leaves. Yield estimation models, using linear regression analysis, were developed and validated from the absolute and normalized measurements of the three optical sensors. Overall, the calibration and validation results indicated that the absolute measurements generally had better yield estimation performance than the normalized indices for all the leaves and different leaf profiles. In both species, there was a better performance at the early phenological stages, such as the vegetative and flowering stages, for the absolute and normalized indices for the three optical sensors. Absolute proximal optical sensor measurements on the lower leaves (L2, L3 and L4) slightly improved yield estimation compared to the L1 leaf. Normalized indices that included the L4 leaf (L1–L4) had better yield estimation compared to those using L2 and L3 (e.g., L1–L2 and L1–L3). Of the normalized indices evaluated, the yield performance of the Relative Index (RI), Relative Difference Index (RDI), and Normalized Difference Index (NDI) were very similar, and generally superior to the Difference Index (DI). Overall, the results of this study demonstrated that for three different proximal optical sensors in both muskmelon and sweet pepper (i) normalized indices did not improve yield estimation, and (ii) that absolute measurements on lower leaves (L2, L3 and L4) slightly improved yield estimation performance.

Abstract Background Mapping the spatial distribution of disease occurrence is a strategy to identify contextual factors that could be useful for public health policies. The purpose of this ecological study was to examine to which extent the socioeconomic deprivation and the urbanization level can explain gender difference of geographic distribution in stroke incidence in Pays de Brest, France between 2008 and 2013. Methods Stroke cases aged 60 years or more were extracted from the Brest stroke registry and combined at the census block level. Contextual socioeconomic, demographic, and geographic variables at the census block level come from the 2013 national census. We used spatial and non-spatial regression models to study the geographic correlation between socioeconomic deprivation, degree or urbanization and stroke incidence. We generated maps using spatial geographically weighted models, after longitude and latitude smoothing and adjustment for covariates. Results Stroke incidence was comparable in women and men (6.26 ± 3.5 vs 6.91 ± 3.3 per 1000 inhabitants-year, respectively). Results showed different patterns of the distribution of stroke risk and its association with deprivation or urbanisation across gender. For women, stroke incidence was spatially homogeneous over the entire study area, but was associated with deprivation level in urban census blocks: age adjusted risk ratio of high versus low deprivation = 1.24, [95%CI 1.04–1.46]. For men, three geographic clusters were identified. One located in the northern rural and deprived census blocks with a 9–14% increase in the risk of stroke. Two others clusters located in the south-eastern (mostly urban part) and south-western (suburban and rural part) with low deprivation level and associated with higher risk of stroke incidence between (3 and 8%) and (8.5 and 19%) respectively. There were no differences in profile of cardiovascular risk factors, stroke type and stroke severity between clusters, or when comparing clusters cases to the rest of the study population. Conclusions Understanding whether and how neighborhood and patient’s characteristics influence stroke risk may be useful for both epidemiological research and healthcare service planning.

Over the past 2 decades, several global burned area products have been produced and released to the public. However, the accuracy assessment of such products largely depends on the availability of reliable reference data that currently do not exist on a global scale or whose production require a high level of dedication of project resources. The important lack of reference data for the validation of burned area products is addressed in this paper. We provide the Burned Area Reference Database (BARD), the first publicly available database created by compiling existing reference BA (burned area) datasets from different international projects. BARD contains a total of 2661 reference files derived from Landsat and Sentinel-2 imagery. All those files have been checked for internal quality and are freely provided by the authors. To ensure database consistency, all files were transformed to a common format and were properly documented by following metadata standards. The goal of generating this database was to give BA algorithm developers and product testers reference information that would help them to develop or validate new BA products. BARD is freely available at https://doi.org/10.21950/BBQQU7 (Franquesa et al., 2020).

The complex composite material cement paste (CP) is under high pressures in underwater applications and when impact loading occurs. The mechanical behavior of cement paste to hydrostatic compression results from mechanical deformations of each phase, including unhydrated and hydrated minerals. Molecular Dynamics was used to study the atomistic deformation of individual unhydrated cement phases with increasing hydrostatic pressures. The pressure-specific volume Birch-Murnaghan equation of state (EoS) and the bulk modulus at zero pressure were determined for each phase. Results show that the bulk modulus and compressibility are pressure dependent. For tricalcium silicate (C3S), dicalcium silicate (C2S), and tricalcium aluminate (C3A), the bulk modulus increases, while the volume compression decreases with increasing pressure. The C3S and C3A phases are stable during hydrostatic compression and exhibit isotropic behavior. The C2S phase is not stable and shows anisotropic behavior. These results explain the effect of unreacted cement clinkers on cement paste mechanical behavior under high pressure based on the response of individual phases.

TiO2 thin films, sensitized by an anthocyanins-rich extract of a common species found in the Colombian Caribbean region (Bactris guineensis fruits), were used for the photocatalytic degradation of methylene blue. The sensitization process was verified by diffuse reflectance spectroscopy (DRS). The qualitative and quantitative analyses of the anthocyanins were carried out using high-performance liquid chromatography with photodiode array detection (HPLC-DAD), which provided the total content anthocyanin equivalent to delphinidin chloride (TAEDC) per mL of the extract, of 10.0 ± 0.8 µg TAEDC/mL. Here, three main anthocyanins were identified, being cyanidin-3-rutinoside the most abundant constituent (ca. 76%). The interaction of the dyes with a TiO2 slab model and their adsorption energies were determined through computational simulations. In addition, the molecular modelling evidenced that the sensitization of the semiconductor improved the light absorption in the visible range of the spectrum. As a final point, the photocatalytic test showed that the photocatalytic activity increased 26% for TiO2/B. guineensis thin films under visible radiation respect to bare TiO2. Keywords: TiO2, Natural sensitizer, Anthocyanin, DFT

Captodative alkene 1-acetylvinyl p-nitrobenzenecarboxylate 1a was evaluated for its reactivity and stereoselectivity with cyclohexadiene (10) in Diels-Alder reactions, showing exclusive endo preference. The two hydrolyzed products of the endo and the exo adducts obtained from the Diels-Alder cycloaddition between 1a and cyclopentadiene (7) were 8b and 9b. When treated with mCPBA, a ring expansion took place to stereospecifically yield the novel 3-oxatricyclo[3.3.1.02,4]nonanone acyloins 15 and 16, respectively. In the case of the α-ketol bicyclo[2.2.2]octanes 11b and 12b, the epoxidation/Baeyer-Villiger cascade process was preferred, resulting in the syn ketoepoxide 19b from each isomer. A synthetic application of this kind of transformation was carried out by reacting ketols 8b and 9b with an excess of mCPBA through a five-step cascade process to yield the bicyclic lactone 27 as a potential precursor of racemic β-carbaxylose. Keywords: Captodative alkenes, 1-Acetylvinyl p-nitrobenzoyloxy, α-Keto carbinols, α-Ketol rearrangement, Cascade process, mCPBA

The practical value of portable hand-held ion selective electrode sensors (ISE) for on-farm [NO3−] measurement to assist with crop N management of vegetable crops has been demonstrated in numerous previous studies. They provide rapid, in-situ measurement of the nitrate concentration ([NO3−]) in nutrient and soil solutions, and in petiole sap. Sample temperatures, for on-farm measurements, vary appreciably. This study evaluated the effects of sample temperature on [NO3−] measurement using two different models of a commonly used, commercially available, portable ISE meter. The temperatures (5, 10, 15, 20, and 25 °C) examined were in the range likely to be encountered in practical on-farm work. Aqueous solutions of 6, 12, and 18 mmol NO3− L−1 were prepared from KNO3, Ca(NO3)2 and NaNO3. [NO3−] was measured in three replicate samples of each of the three concentrations, made from each NO3− compound, at each temperature. The results consistently and clearly demonstrated a strong negative linear relationship between temperature-induced errors and sample temperatures. The temperature-induced error was considerable for cooled samples, being +50% at 5 °C and +31% at 10 °C. At sample temperatures of 17–20 °C, the temperature effects were minimal. Above this range, the temperature effect caused underestimation. At 25 °C, the temperature-induced error was −24%. These results show that care must be taken to ensure that sample temperatures do not erroneously affect the measurement of [NO3−] with ISE meters. Particular care needs to be taken with both refrigerated and warmer samples.

Yield and fruit quality are two of the most important parameters for the profitability of vegetable crops. In commercial vegetable production, nitrogen (N) is commonly applied in excess, which is associated with nitrate (NO3−) leaching loss. In addition, excess N application may affect yield and fruit quality. The aim of this study was to evaluate the effect of N applications of very deficient N (N1, 2 mmol L−1), deficient N (N2, 8 mmol L−1), and conventional N (N3, 14 mmol L−1), according to local fertigation practices, in soil-grown muskmelon and sweet pepper crops in Almeria, South-Eastern Spain. The evaluation was conducted in three cultivars of each species. The yield and the fruit quality parameters of firmness, colour, total soluble solids (TSS) and morphometric variables were evaluated in two years for each species. For most parameters in both species, the effects of N, when significant, occurred regardless of cultivar. In muskmelon and sweet pepper, application of 8.2 mmol N L−1 (i.e., N2) was sufficient to achieve a maximum yield of 6.7 and 7.4 kg m−2, respectively. In muskmelon, very deficient N application led to an increase of 58% in the percentage of fruit discarded, mostly due to malformed and undersized fruits. Fruit firmness and red–green axis coordinate (a*) were not consistently affected by N in any of the crops. However, the fruit lightness (L*) increased with N addition in both species, likely because of increased chlorophyll pigments. With N addition, fruit TSS slightly decreased in muskmelon and slightly increased in sweet pepper. However, fruit TSS of both species were within reference values for commercialisation in the three N treatments. There were differences in yield between cultivars in muskmelon but not in sweet pepper, likely due to differences in fruit number in muskmelon. There were differences between cultivars in TSS and colour a* coordinate in both muskmelon and sweet pepper. Cultivars with higher TSS and a* coordinate will likely be more desirable for consumers because of the sweeter taste and more intense orange colour in muskmelon and reddish colour in sweet pepper. Overall, our manuscript showed that N application can be reduced, relative to the conventional N application, without reducing yield or fruit quality in muskmelon, yet additional studies should be conducted in sweet pepper to complement the results of the 2020 crop.

Aim of study: Soil compaction causes an increase in bulk density, resistance to penetration, low diffusion of oxygen and water in the soil. Tillage is one of the techniques to alleviate compaction. The objective of this work was to evaluate the effects of tillage on sweet pepper grown in greenhouse soil. Area of study: The experimental work was conducted in a plastic greenhouse at the Experimental Station of the University of Almería (SE Spain). Material and methods: The soil was ploughed with a single pass with ripper to 15 cm depth and with rotavator to 10 cm depth. The control treatment was soil untilled. Crop dry matter production and root length growth and density of sweet pepper were evaluated, in addition to soil characteristics such as bulk density, resistance to penetration and soil matric potential. Main results: Tillage reduced soil bulk density from 1.70 to 1.60 kg L-1 in the 10-40 cm of soil depth. There was a notable reduction in irrigation (12%), total N applied (13%), drainage (91%) and N leaching (95%) in the tillage treatment. However, tillage did not improve significantly crop dry matter production and yield. The absence of tillage effect is possible due to a slight reduction in the bulk density of the soil. Research highlights: The tillage treatment produced a notable reduction in irrigation, total N applied, drainage and N leaching when compared to the control.

Milk is a liquid food that possesses an important quantity of highly bioavailable macronutrients. In addition, it is readily accessible, as well as relatively inexpensive. Given that the knowledge of physicians about nutrition and food composition is deficient, in general, many of the dietary interventions recommended in diverse clinical settings lack a scientific basis. The aim of the present review was to produce a technical opinion that serves as a frame of reference to best sustain recommendations for consuming milk and dairy products as daily nutrition in the adult and older adult. The effects of milk and dairy products during the pediatric stage are not addressed in the present work. The Asociación Mexicana de Gastroenterología and the Asociación Mexicana de Gerontología y Geriatría jointly discussed and analyzed topics dealing with the legal designation of milk, the classification and nutritional profile of cow's milk, its nutritional characteristics, its consumption in the adult, intolerance to cow's milk, and associations of milk consumption with digestive tract alterations and other conditions. Finally, certain aspects of milk consumption in the older adult and its relation to overall health are briefly discussed. Resumen: La leche es un alimento que tiene una importante cantidad de macronutrimentos de gran biodisponibilidad, accesible y de relativo bajo costo. El conocimiento de los médicos en general sobre nutrición y composición de los alimentos es deficiente por lo que muchas de las intervenciones dietéticas que tradicionalmente recomendamos en diversos escenarios clínicos carecen de sustento científico. El objetivo de esta revisión fue generar una opinión técnica que sirva como marco de referencia para sustentar de mejor forma la recomendación sobre el consumo de leche y productos lácteos en la nutrición diaria de adultos y adultos mayores. Los efectos de la leche y productos lácteos durante la etapa pediátrica salen del contexto del presente trabajo. La Asociación Mexicana de Gastroenterología y la Asociación Mexicana de Gerontología y Geriatría comentaron y analizaron de forma conjunta temas acerca de la denominación legal de la leche, clasificación y perfil nutrimental de la leche de vaca, sus características nutrimentales, su consumo en el adulto, intolerancia a la leche de vaca, asociaciones entre el consumo de leche y alteraciones del aparato digestivo y otras condiciones; finalmente, se mencionan de forma breve algunos aspectos sobre el consumo de leche en el adulto mayor y su relación con la salud. Keywords: Dairy products, Cow's milk, Diet, Adult, Older adult, Palabras clave: Lácteos, Leche de vaca, Alimentación, Adulto, Adulto mayor

Resumen: La leche es un alimento que tiene una importante cantidad de macronutrimentos de gran biodisponibilidad, accesible y de relativo bajo costo. El conocimiento de los médicos en general sobre nutrición y composición de los alimentos es deficiente por lo que muchas de las intervenciones dietéticas que tradicionalmente recomendamos en diversos escenarios clínicos carecen de sustento científico. El objetivo de esta revisión fue generar una opinión técnica que sirva como marco de referencia para sustentar de mejor forma la recomendación sobre el consumo de leche y productos lácteos en la nutrición diaria de adultos y adultos mayores. Los efectos de la leche y productos lácteos durante la etapa pediátrica salen del contexto del presente trabajo. La Asociación Mexicana de Gastroenterología y la Asociación Mexicana de Gerontología y Geriatría comentaron y analizaron de forma conjunta temas acerca de la denominación legal de la leche, clasificación y perfil nutrimental de la leche de vaca, sus características nutrimentales, su consumo en el adulto, intolerancia a la leche de vaca, asociaciones entre el consumo de leche y alteraciones del aparato digestivo y otras condiciones; finalmente, se mencionan de forma breve algunos aspectos sobre el consumo de leche en el adulto mayor y su relación con la salud. Abstract: Milk is a liquid food that possesses an important quantity of highly bioavailable macronutrients. In addition, it is readily accessible, as well as relatively inexpensive. Given that the knowledge of physicians about nutrition and food composition is deficient, in general, many of the dietary interventions recommended in diverse clinical settings lack a scientific basis. The aim of the present review was to produce a technical opinion that serves as a frame of reference to best sustain recommendations for consuming milk and dairy products as daily nutrition in the adult and older adult. The effects of milk and dairy products during the pediatric stage are not addressed in the present work. The Asociación Mexicana de Gastroenterología and the Asociación Mexicana de Gerontología y Geriatría jointly discussed and analyzed topics dealing with the legal designation of milk, the classification and nutritional profile of cow's milk, its nutritional characteristics, its consumption in the adult, intolerance to cow's milk, and associations of milk consumption with digestive tract alterations and other conditions. Finally, certain aspects of milk consumption in the older adult and its relation to overall health are briefly discussed. Palabras clave: Lácteos, Leche de vaca, Alimentación, Adulto, Adulto mayor, Keywords: Dairy products, Cow's milk, Diet, Adult, Older adult

Trypanosoma cruzi, the causative agent of human Chagas disease, is endemic to the southern region of the United States where it routinely infects many host species. The indoor/outdoor housing configuration used in many non-human primate research and breeding facilities in the southern of the USA provides the opportunity for infection by T. cruzi and thus provides source material for in-depth investigation of host and parasite dynamics in a natural host species under highly controlled and restricted conditions. For cynomolgus macaques housed at such a facility, we used a combination of serial blood quantitative PCR (qPCR) and hemoculture to confirm infection in >92% of seropositive animals, although each method alone failed to detect infection in >20% of cases. Parasite isolates obtained from 43 of the 64 seropositive macaques were of 2 broad genetic types (discrete typing units, (DTU's) I and IV); both within and between these DTU groupings, isolates displayed a wide variation in growth characteristics and virulence, elicited host immune responses, and susceptibility to drug treatment in a mouse model. Likewise, the macaques displayed a diversity in T cell and antibody response profiles that rarely correlated with parasite DTU type, minimum length of infection, or age of the primate. This study reveals the complexity of infection dynamics, parasite phenotypes, and immune response patterns that can occur in a primate group, despite being housed in a uniform environment at a single location, and the limited time period over which the T. cruzi infections were established.

Parent engagement has been a cornerstone of Head Start since its inception in 1965. Prior studies have found evidence for small to moderate impacts of Head Start on parenting behaviors but have not considered the possibility that individual Head Start programs might vary meaningfully in their effectiveness at improving parenting outcomes. The present study uses the Head Start Impact Study to examine the average effect of random assignment to and participation in Head Start on parenting outcomes as well as variation in that effect across Head Start programs. Findings reveal that Head Start is effective on average at promoting parents’ daily reading and overall literacy and math activities with children but that effects vary significantly for parents’ literacy and math activities, with some programs much more and some much less effective than their local alternatives. Findings also demonstrate that Head Start has consistent near-zero impacts across centers on parents’ disciplinary interactions with children.

The identification and treatment of paroxysmal sympathetic hyperactivity (PSH) still present a significant challenge. We assessed the efficacy of pharmacological agents in treating PSH symptoms and the validity of the diagnostic scales in a cohort of Hispanic patients. A retrospective chart review of cases from a single hospital was conducted in 464 records. Exclusion criteria included underlying conditions such as severe infection. Only nine patients remained in the cohort after examining their clinical records, corresponding to the following diagnoses: traumatic brain injury, subdural hemorrhage, anoxic or ischemic encephalopathy, pneumocephalus, and cerebral palsy. Using the PSH likelihood scale, six of the nine patients were identified with a score of 17 or higher, corresponding to a “probable” PSH, and three patients obtained a score between 8 and 16, corresponding to a “possible” PSH diagnosis. The top three classes of medications used were beta-blockers, antipyretics, and opioids. Benzodiazepines and neuromodulators were also frequently used in patients with trauma, but not in the ones with non-traumatic injuries. Interestingly, 75% of the patients have prescribed levothyroxine as a home medication after the PSH presentation. Medication administration did not follow a specific pattern, suggesting high variability in the management of PSH within our setting, requiring further research. Our results suggest that the pituitary axis might be involved in the progression of PSH. Establishing a specific medical code (e.g., ICD-10) describing PSH as a single entity is essential for appropriate identification and management.