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1. Technical note: A low-cost, automatic soil–plant–atmosphere enclosure system to investigate CO2 and evapotranspiration flux dynamics

Author: W. Al Hamwi, M. Dubbert, J. Schaller, M. Lück, M. Schmidt, and M. Hoffmann
Subjects: Ecology, QH540-549.5, Life, QH501-531, Geology, QE1-996.5
Abstract: Investigating greenhouse gases (GHGs) and water flux dynamics within the soil–plant–atmosphere interphase is key for understanding ecosystem functioning, as they reflect the ecosystem's responses to environmental changes. Understanding these responses is essential for developing sustainable agricultural systems that can help to adapt to global challenges such as increased drought. Typically, an initial understanding of GHGs and water flux dynamics is gained through laboratory or greenhouse pot experiments, where gas exchange is often measured using commercially available manual closed-chamber (leaf) systems. However, these systems are rather expensive and often labor-intensive, thus limiting the number of different treatments and their repetitions that can be studied. Here, we present a fully automatic, low-cost (EUR per unit) multi-chamber system based on Arduino, termed “greenhouse coffins”. It is designed to continuously measure canopy CO2 and evapotranspiration (ET) fluxes. It can operate in two modes: an independent and a dependent measurement mode. The independent measurement mode utilizes low-cost NDIR (non-dispersive infrared) CO2 (K30 FR) and relative humidity (SHT31) sensors, thus making each greenhouse coffin a fully independent measurement device. The dependent measurement mode connects multiple greenhouse coffins via a low-cost multiplexer (EUR ) to a single infrared gas analyzer (LI-850, LI-COR Inc., Lincoln, USA), allowing for measurements in series, achieving cost efficiency while also gaining more flexibility in terms of target GHG fluxes (potential extension to N2O, CH4 and stable isotopes). In both modes, CO2 and ET fluxes are determined through the respective concentration increase during closure time. We tested both modes and demonstrated that the presented system is able to deliver precise and accurate CO2 and ET flux measurements using low-cost sensors, with an emphasis on calibrating the sensors to improve measurement precision. By connecting multiple greenhouse coffins via our low-cost multiplexer to a single infrared gas analyzer in the dependent mode, we could additionally show that the system can efficiently measure CO2 and ET fluxes in a high temporal resolution across various treatments with both labor and cost efficiency. Therefore, the developed system is expected to be a valuable tool for conducting greenhouse experiments, enabling comprehensive testing of plant–soil dynamic responses to various treatments and conditions.
Published: 2024
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2. On ultrafast x-ray scattering methods for magnetism

Author: R. Plumley, S. R. Chitturi, C. Peng, T. A. Assefa, N. Burdet, L. Shen, Z. Chen, A. H. Reid, G. L. Dakovski, M. H. Seaberg, F. O’Dowd, S. A. Montoya, H. Chen, A. Okullo, S. Mardanya, S. D. Kevan, P. Fischer, E. E. Fullerton, S. K. Sinha, W. Colocho, A. Lutman, F.-J. Decker, S. Roy, J. Fujioka, Y. Tokura, M. P. Minitti, J. A. Johnson, M. Hoffmann, M. E. Amoo, A. Feiguin, C. Yoon, J. Thayer, Y. Nashed, C. Jia, A. Bansil, S. Chowdhury, A. M. Lindenberg, M. Dunne, E. Blackburn, and J. J. Turner
Subjects: Ultrafast, x-rays, magnetism, x-ray free electron lasers, machine-learning, instrumentation, Physics, QC1-999
Abstract: With the introduction of x-ray free electron laser sources around the world, new scientific approaches for visualizing matter at fundamental length and time-scales have become possible. As it relates to magnetism and ‘magnetic-type’ systems, advanced scattering methods are being developed for studying ultrafast magnetic responses on the time-scales at which they occur. We describe three capabilities which have the potential to seed new directions in this area and presentoriginal results from each: pump-probe x-ray scattering with low energy excitation, x-ray photon fluctuation spectroscopy, and ultrafast diffuse x-ray scattering. By combining these experimental techniques with advanced modeling together with machine learning, we describe how the combination of these domains allows for a new understanding in the field of magnetism. Finally, we give an outlook for future areas of investigation and the newly developed instruments which will take us there.
Published: 2024
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3. Ferroelectric Hafnia: A New Age for FRAM has Started.

Author: S. Mueller, A. Palludo, D. Ferrario, M. Ghazaryan, D. Le Minh, M. Noack, A. Daraghmah, L. Paone, M. Pagliato, J. Ocker, M. Hoffmann, T. Werner, A. Kashir, F. Tassan, and T. Schenk
Published: 2024
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4. Integrating ORNL's HPC and Neutron Facilities with a Performance-Portable CPU/GPU Ecosystem.

Author: Steven E. Hahn, Philip W. Fackler, William F. Godoy, Ketan Maheshwari, Zachary Morgan, Andrei T. Savici, Christina M. Hoffmann, Pedro Valero-Lara, Jeffrey S. Vetter, and Rafael Ferreira da Silva
Published: 2024
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5. Cohort profile: the Swiss Mother and Child HIV Cohort Study (MoCHiV)

Author: PA Crisinel, P Paioni, N Müller, A Anagnostopoulos, M Hoffmann, Huldrych Günthard, J Böni, J Schüpbach, M Baumann, D Nadal, Christoph Rudin, M Egger, C-A Siegrist, N Wagner, J Németh, A Duppenthaler, J Notter, L Kaiser, J-J CHESEAUX, P Schmid, A Rauch, M Huber, C Rudin, B Ledergerber, A Calmy, M Cavassini, M Rickenbach, H Furrer, M Battegay, L Elzi, Andri Rauch, B Hirschel, E Bernasconi, HC Bucher, J Fehr, J Fellay, CA Fux, D Haerry, B Hasse, HH Hirsch, I Hösli, O Keiser, T Klimkait, H Kovari, B Martinez de Tejada, G Pantaleo, R Speck, P Tarr, A Trkola, S Yerly, P Francioli, Andrea Duppenthaler, Karoline Aebi-Popp, Noemie Wagner, Paolo Paioni, Murezi Capaul, Anja Brunner, Anna Traytel, Pierre-Alex Crisinel, Begona Martinez De Tejada, Lisa Kottanattu, Marcel Stöckle, Irene Hösli, Alexandra Scherrer, Katharina Kusejko, Christian R Kahlert, I Abela, K Aebi-Popp, DL Braun, A Ciuffi, K Darling, G Dollenmaier, K Francini, HF Günthard, A Hachfeld, D Jackson-Perry, CR Kahlert, E Kapfhammer, M Kohns, L Kottanattu, RD Kouyos, K Kusejko, N Labhardt, C Marzolini, KJ Metzner, D Nicca, M Perreau, Polli Ch, L Salazar-Vizcaya, M Stöckle, M Thanh Lecompte, G Wandeler, M Weisser, and C Kind
Subjects: Medicine
Abstract: Purpose Prospective, multicentric observational cohort study in Switzerland investigating measures to prevent mother-to-child transmission in pregnant women with HIV (WWH) and assessing health and development of their exposed children as well as of children with HIV (CWH) in general.Participants Between January 1986 and December 2022, a total of 1446 mother–child pairs were enrolled. During the same period, the study also registered 187 CWH and 521 HIV-exposed but uninfected children (HEU), for whom detailed maternal information was not available. Consequently, the cohort comprises a total of 2154 children.Findings to date During these 37 years, research by the Swiss Mother and Child HIV Cohort Study (MoCHiV) and its international collaborators has strongly influenced the prevention of vertical transmission of HIV (eg, introduction and discontinuation of elective caesarean section, neonatal postexposure prophylaxis and breastfeeding). Contributions have also been made to the management of diagnostics (eg, p24 antigen assay) and the effects of antiretroviral treatment (eg, prematurity, growth) in HEU and CWH.Future plans Most children present within the cohort are now HEU, highlighting the need to investigate other vertically transmitted pathogens such as hepatitis B and C viruses, cytomegalovirus or Treponema pallidum. In addition, analyses are planned on the longitudinal health status of CWH (eg, resistance and prolonged exposure to antiretroviral therapy), on social aspects including stigma in CWH and HEU, and on interventions to further optimise antenatal and postpartum care in WWH.
Published: 2024
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6. Rigid crosslinking of the CD3 complex leads to superior T cell stimulation

Author: Alfreda D. Nelson, Liangyu Wang, Kimberly G. Laffey, Laura R. E. Becher, Christopher A. Parks, Michele M. Hoffmann, Belinda K. Galeano, Ashutosh Mangalam, Emma Teixeiro, Tommi A. White, Adam G. Schrum, John F. Cannon, and Diana Gil
Subjects: T cell receptor engagement and triggering, antibody fragment structure, CD3/antibody crosslinking, T cell division and apoptosis, anti-CD3 Fab-based therapies, EAE (experimental autoimmune encephalomyelitis), Immunologic diseases. Allergy, RC581-607
Abstract: Functionally bivalent non-covalent Fab dimers (Bi-Fabs) specific for the TCR/CD3 complex promote CD3 signaling on T cells. While comparing functional responses to stimulation with Bi-Fab, F(ab’)2 or mAb specific for the same CD3 epitope, we observed fratricide requiring anti-CD3 bridging of adjacent T cells. Surprisingly, anti-CD3 Bi-Fab ranked first in fratricide potency, followed by anti-CD3 F(ab’)2 and anti-CD3 mAb. Low resolution structural studies revealed anti-CD3 Bi-Fabs and F(ab’)2 adopt similar global shapes with CD3-binding sites oriented outward. However, under molecular dynamic simulations, anti-CD3 Bi-Fabs crosslinked CD3 more rigidly than F(ab’)2. Furthermore, molecular modelling of Bi-Fab and F(ab’)2 binding to CD3 predicted crosslinking of T cell antigen receptors located in opposing plasma membrane domains, a feature fitting with T cell fratricide observed. Thus, increasing rigidity of Fab-CD3 crosslinking between opposing effector-target pairs may result in stronger T cell effector function. These findings could guide improving clinical performance of bi-specific anti-CD3 drugs.
Published: 2024
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7. Validation and field application of a low-cost device to measure CO2 and evapotranspiration (ET) fluxes

Author: R. Macagga, M. Asante, G. Sossa, D. Antonijević, M. Dubbert, and M. Hoffmann
Subjects: Environmental engineering, TA170-171, Earthwork. Foundations, TA715-787
Abstract: Mitigating the global climate crisis and its consequences, such as more frequent and severe droughts, is one of the major challenges for future agriculture. Therefore, identifying land use systems and management practices that reduce greenhouse gas (GHG) emissions and promote water use efficiency (WUE) is crucial. This, however, requires accurate and precise measurements of carbon dioxide (CO2) fluxes and evapotranspiration (ET). Despite that, commercial systems to measure CO2 and ET fluxes are expensive and thus often exclude research in ecosystems within the Global South. This is especially true for research and data of agroecosystems in these areas, which are to date still widely underrepresented. Here, we present a newly developed low-cost, non-dispersive infrared (NDIR)-based CO2 and ET flux measurement device (∼ EUR 200) that provides reliable, accurate and precise CO2 and ET flux measurements in conjunction with manually operated closed chambers. To validate the system, laboratory and field validation experiments were performed, testing multiple different low-cost sensors. We demonstrate that the system delivers accurate and precise CO2 and ET flux measurements using the K30 FR NDIR (CO2) and SHT31 (RH, relative humidity) sensor. An additional field trial application demonstrated its longer-term stability (> 3 months) and ability to obtain valid net ecosystem C balances (NECBs) and WUE. This was the case, even though environmental conditions at the field trial application site in sub-Saharan Africa were rather challenging (e.g., extremely high temperatures, humidity and rainfall). Consequently, the developed low-cost CO2 and ET flux measurement device not only provides reasonable results but also might help with democratizing science and closing current data gaps.
Published: 2024
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8. Benefits of a robotic chamber system for determining evapotranspiration in an erosion-affected, heterogeneous cropland

Author: A. Dahlmann, M. Hoffmann, G. Verch, M. Schmidt, M. Sommer, J. Augustin, and M. Dubbert
Subjects: Technology, Environmental technology. Sanitary engineering, TD1-1066, Geography. Anthropology. Recreation, Environmental sciences, GE1-350
Abstract: In the light of the ongoing global climate crisis and the related increases in extreme hydrological events, it is crucial to assess ecosystem resilience and – in agricultural systems – to ensure sustainable management and food security. For this purpose, a comprehensive understanding of ecosystem water cycle budgets and spatiotemporal dynamics is indispensable. Evapotranspiration (ET) plays a pivotal role in returning up to 90 % of incoming precipitation back to the atmosphere. Here, we studied the impacts of soil types and management on an agroecosystem's seasonal cumulative ET (ETsum) and agronomic water use efficiency (WUEagro, the dry matter per unit of water used by the crop). To do so, a plot experiment with winter rye (17 September 2020 to 30 June 2021) was conducted in an eroded cropland which is located in the hilly and dry ground moraine landscape of the Uckermark region in northeastern Germany. Along the experimental plot (110 m × 16 m), two closed chambers were mounted on a robotic gantry crane system (FluxCrane as part of the AgroFlux platform) and used to determine ET. Three soil types representing the full soil erosion gradient related to the hummocky ground moraine landscape (extremely eroded: Calcaric Regosol; strongly eroded: Nudiargic Luvisol; non-eroded: Calcic Luvisol) and additional topsoil dilution (topsoil removal and subsoil admixture) were investigated (randomized block design, three replicates per treatment). Five different modeling approaches were used and compared in the light of their potential for reliable ETsum over the entire crop cultivation period and to reproduce short-term (e.g., diurnal) water flux dynamics. While machine-learning approaches such as support vector machines (SVMs) and artificial neural networks (with Bayesian regularization; ANN_BR) generally performed well during calibration, SVMs also provided a satisfactory prediction of measured ET during validation (k-fold cross-validation, k=5). We found significant differences in dry biomass (DM) and small trends in ETsum between soil types, resulting in different WUEagro. The extremely eroded Calcaric Regosol showed an up to 46 % lower ETsum and up to 54 % lower WUEagro compared to the non-eroded Calcic Luvisol. The key period contributing to 70 % of ETsum spanned the beginning of stem elongation in April to the harvest in June. However, differences in the ETsum between soil types and topsoil dilution resulted predominantly from small differences between the treatments throughout the cultivation rather than only during this short period of time.
Published: 2023
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9. Development and evaluation of a point-of-care ocular ultrasound curriculum for medical students - a proof-of-concept study

Author: Johannes Matthias Weimer, Maximilian Rink, Thomas Vieth, Jonas Lauff, Andreas Weimer, Lukas Müller, Marie Stäuber, Sebastian R. Reder, Holger Buggenhagen, Henrik Bellhäuser, Roman Kloeckner, Julian Künzel, Esther M. Hoffmann, and Anna Würde
Subjects: Point-of-care-sonography, POCUS, Ocular ultrasound, POCOUS, Ultrasound training, Curriculum development, Special aspects of education, LC8-6691, Medicine
Abstract: Abstract Background Point-of-care Ocular Ultrasound (POCOUS) has gained importance in emergency medicine and intensive care in recent years. This work aimed to establish and evaluate a dedicated ultrasound education program for learning POCOUS-specific skills during medical studies at a university hospital. Methods The blended learning-based program (6 teaching units) based on recent scientific publications and recommendations was developed for students in the clinical part of their medical studies. Experts and trainers consisted of physicians from the Ear-Nose-Throat, radiology, ophthalmology and neurology specialties as well as university educational specialists. Lecture notes containing digital video links for preparation was produced as teaching material. In total, 33 students participated in the study. The education program, including the teaching materials, motivation and subjective gain in competency, was evaluated with the aid of a questionnaire (7-point Likert response format). Objective learning success was assessed on the basis of pre- and post-tests. These covered the skill areas: “anatomical basics”, “ultrasound basics”, “understanding of cross-sectional images”, “normal findings” and “pathology recognition”. Results In the objective assessment of image interpretation, the participants improved significantly (p
Published: 2023
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10. Genetic association between the APOE ε4 allele, toxicant exposures and Gulf war illness diagnosis

Author: L Abdullah, A Nkiliza, D Niedospial, G Aldrich, G Bartenfelder, A Keegan, M Hoffmann, M Mullan, N Klimas, J Baraniuk, F Crawford, M Krengel, L Chao, and K Sullivan
Subjects: Gulf War Illness, Apolipoprotein E, Pesticides, Pyridostigmine bromide and oil well fires, Industrial medicine. Industrial hygiene, RC963-969, Public aspects of medicine, RA1-1270
Abstract: Abstract Introduction Exposure to nerve agents, pyridostigmine bromide (PB), pesticides, and oil-well fires during the 1991 Gulf War (GW) are major contributors to the etiology of Gulf War Illness (GWI). Since the apolipoprotein E (APOE) ε4 allele is associated with the risk of cognitive decline with age, particularly in the presence of environmental exposures, and cognitive impairment is one of the most common symptoms experienced by veterans with GWI, we examined whether the ε4 allele was associated with GWI. Methods Using a case-control design, we obtained data on APOE genotypes, demographics, and self-reported GW exposures and symptoms that were deposited in the Boston Biorepository and Integrative Network (BBRAIN) for veterans diagnosed with GWI (n = 220) and healthy GW control veterans (n = 131). Diagnosis of GWI was performed using the Kansas and/or Center for Disease Control (CDC) criteria. Results Age- and sex-adjusted analyses showed a significantly higher odds ratio for meeting the GWI case criteria in the presence of the ε4 allele (Odds ratio [OR] = 1.84, 95% confidence interval [CI = 1.07–3.15], p ≤ 0.05) and with two copies of the ε4 allele (OR = 1.99, 95% CI [1.23–3.21], p ≤ 0.01). Combined exposure to pesticides and PB pills (OR = 4.10 [2.12–7.91], p ≤ 0.05) as well as chemical alarms and PB pills (OR = 3.30 [1.56–6.97] p ≤ 0.05) during the war were also associated with a higher odds ratio for meeting GWI case criteria. There was also an interaction between the ε4 allele and exposure to oil well fires (OR = 2.46, 95% CI [1.07–5.62], p ≤ 0.05) among those who met the GWI case criteria. Conclusion These findings suggest that the presence of the ε4 allele was associated with meeting the GWI case criteria. Gulf War veterans who reported exposure to oil well fires and have an ε4 allele were more likely to meet GWI case criteria. Long-term surveillance of veterans with GWI, particularly those with oil well fire exposure, is required to better assess the future risk of cognitive decline among this vulnerable population.
Published: 2023
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11. B cell profiles, antibody repertoire and reactivity reveal dysregulated responses with autoimmune features in melanoma

Author: Silvia Crescioli, Isabel Correa, Joseph Ng, Zena N. Willsmore, Roman Laddach, Alicia Chenoweth, Jitesh Chauhan, Ashley Di Meo, Alexander Stewart, Eleni Kalliolia, Elena Alberts, Rebecca Adams, Robert J. Harris, Silvia Mele, Giulia Pellizzari, Anna B. M. Black, Heather J. Bax, Anthony Cheung, Mano Nakamura, Ricarda M. Hoffmann, Manuela Terranova-Barberio, Niwa Ali, Ihor Batruch, Antoninus Soosaipillai, Ioannis Prassas, Antigona Ulndreaj, Miyo K. Chatanaka, Rosamund Nuamah, Shichina Kannambath, Pawan Dhami, Jenny L. C. Geh, Alastair D. MacKenzie Ross, Ciaran Healy, Anita Grigoriadis, David Kipling, Panagiotis Karagiannis, Deborah K. Dunn-Walters, Eleftherios P. Diamandis, Sophia Tsoka, James Spicer, Katie E. Lacy, Franca Fraternali, and Sophia N. Karagiannis
Subjects: Science
Abstract: Abstract B cells are known to contribute to the anti-tumor immune response, especially in immunogenic tumors such as melanoma, yet humoral immunity has not been characterized in these cancers to detail. Here we show comprehensive phenotyping in samples of circulating and tumor-resident B cells as well as serum antibodies in melanoma patients. Memory B cells are enriched in tumors compared to blood in paired samples and feature distinct antibody repertoires, linked to specific isotypes. Tumor-associated B cells undergo clonal expansion, class switch recombination, somatic hypermutation and receptor revision. Compared with blood, tumor-associated B cells produce antibodies with proportionally higher levels of unproductive sequences and distinct complementarity determining region 3 properties. The observed features are signs of affinity maturation and polyreactivity and suggest an active and aberrant autoimmune-like reaction in the tumor microenvironment. Consistent with this, tumor-derived antibodies are polyreactive and characterized by autoantigen recognition. Serum antibodies show reactivity to antigens attributed to autoimmune diseases and cancer, and their levels are higher in patients with active disease compared to post-resection state. Our findings thus reveal B cell lineage dysregulation with distinct antibody repertoire and specificity, alongside clonally-expanded tumor-infiltrating B cells with autoimmune-like features, shaping the humoral immune response in melanoma.
Published: 2023
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12. The transcription factor VAX1 in VIP neurons of the suprachiasmatic nucleus impacts circadian rhythm generation, depressive-like behavior, and the reproductive axis in a sex-specific manner in mice

Author: Brooke M. Van Loh, Alexandra M. Yaw, Joseph A. Breuer, Brooke Jackson, Duong Nguyen, Krystal Jang, Fabiola Ramos, Emily V. Ho, Laura J. Cui, Dominique L. M. Gillette, Lorenzo F. Sempere, Michael R. Gorman, Karen J. Tonsfeldt, Pamela L. Mellon, and Hanne M. Hoffmann
Subjects: ventral anterior homeobox 1, vasoactive intestinal peptide, arginine vasopressin, suprachiasmatic nucleus, reproduction, premenstrual disorders, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract: BackgroundThe suprachiasmatic nucleus (SCN) within the hypothalamus is a key brain structure required to relay light information to the body and synchronize cell and tissue level rhythms and hormone release. Specific subpopulations of SCN neurons, defined by their peptide expression, regulate defined SCN output. Here we focus on the vasoactive intestinal peptide (VIP) expressing neurons of the SCN. SCN VIP neurons are known to regulate circadian rhythms and reproductive function. MethodsTo specifically study SCN VIP neurons, we generated a novel knock out mouse line by conditionally deleting the SCN enriched transcription factor, Ventral Anterior Homeobox 1 (Vax1), in VIP neurons (Vax1Vip; Vax1fl/fl:VipCre).ResultsWe found that Vax1Vip females presented with lengthened estrous cycles, reduced circulating estrogen, and increased depressive-like behavior. Further, Vax1Vip males and females presented with a shortened circadian period in locomotor activity and ex vivo SCN circadian period. On a molecular level, the shortening of the SCN period was driven, at least partially, by a direct regulatory role of VAX1 on the circadian clock genes Bmal1 and Per2. Interestingly, Vax1Vip females presented with increased expression of arginine vasopressin (Avp) in the paraventricular nucleus, which resulted in increased circulating corticosterone. SCN VIP and AVP neurons regulate the reproductive gonadotropin-releasing hormone (GnRH) and kisspeptin neurons. To determine how the reproductive neuroendocrine network was impacted in Vax1Vip mice, we assessed GnRH sensitivity to a kisspeptin challenge in vivo. We found that GnRH neurons in Vax1Vip females, but not males, had an increased sensitivity to kisspeptin, leading to increased luteinizing hormone release. Interestingly, Vax1Vip males showed a small, but significant increase in total sperm and a modest delay in pubertal onset. Both male and female Vax1Vip mice were fertile and generated litters comparable in size and frequency to controls.ConclusionTogether, these data identify VAX1 in SCN VIP neurons as a neurological overlap between circadian timekeeping, female reproduction, and depressive-like symptoms in mice, and provide novel insight into the role of SCN VIP neurons.
Published: 2023
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13. Workflow for phenotyping sugar beet roots by automated evaluation of cell characteristics and tissue arrangement using digital image processing

Author: Nelia Nause, Facundo R. Ispizua Yamati, Marion Seidel, Anne-Katrin Mahlein, and Christa M. Hoffmann
Subjects: Sugar beet, Histology, Histologic evaluation, Digital image processing, Phenotyping, Plant culture, SB1-1110, Biology (General), QH301-705.5
Abstract: Abstract Background Cell characteristics, including cell type, size, shape, packing, cell-to-cell-adhesion, intercellular space, and cell wall thickness, influence the physical characteristics of plant tissues. Genotypic differences were found concerning damage susceptibility related to beet texture for sugar beet (Beta vulgaris). Sugar beet storage roots are characterized by heterogeneous tissue with several cambium rings surrounded by small-celled vascular tissue and big-celled sugar-storing parenchyma between the rings. This study presents a procedure for phenotyping heterogeneous tissues like beetroots by imaging. Results Ten Beta genotypes (nine sugar beet and one fodder beet) were included to establish a pipeline for the automated histologic evaluation of cell characteristics and tissue arrangement using digital image processing written in the programming language R. The identification of cells has been validated by comparison with manual cell identification. Cells are reliably discriminated from intercellular spaces, and cells with similar morphological features are assigned to biological tissue types. Conclusions Genotypic differences in cell diameter and cell arrangement can straightforwardly be phenotyped by the presented workflow. The presented routine can further identify genotypic differences in cell diameter and cell arrangement during early growth stages and between sugar storage capabilities.
Published: 2023
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14. Erratum: Measurement of prompt and nonprompt charmonium suppression in PbPb collisions at 5.02 TeV

Author: A. M. Sirunyan, A. Tumasyan, W. Adam, F. Ambrogi, E. Asilar, T. Bergauer, J. Brandstetter, E. Brondolin, M. Dragicevic, J. Erö, A. Escalante Del Valle, M. Flechl, M. Friedl, R. Frühwirth, V. M. Ghete, J. Grossmann, J. Hrubec, M. Jeitler, A. König, N. Krammer, I. Krätschmer, D. Liko, T. Madlener, I. Mikulec, E. Pree, N. Rad, H. Rohringer, J. Schieck, R. Schöfbeck, M. Spanring, D. Spitzbart, W. Waltenberger, J. Wittmann, C.-E. Wulz, M. Zarucki, V. Chekhovsky, V. Mossolov, J. Suarez Gonzalez, E. A. De Wolf, D. Di Croce, X. Janssen, J. Lauwers, M. Van De Klundert, H. Van Haevermaet, P. Van Mechelen, N. Van Remortel, S. Abu Zeid, F. Blekman, J. D’Hondt, I. De Bruyn, J. De Clercq, K. Deroover, G. Flouris, D. Lontkovskyi, S. Lowette, I. Marchesini, S. Moortgat, L. Moreels, Q. Python, K. Skovpen, S. Tavernier, W. Van Doninck, P. Van Mulders, I. Van Parijs, D. Beghin, B. Bilin, H. Brun, B. Clerbaux, G. De Lentdecker, H. Delannoy, B. Dorney, G. Fasanella, L. Favart, R. Goldouzian, A. Grebenyuk, A. K. Kalsi, T. Lenzi, J. Luetic, T. Maerschalk, A. Marinov, T. Seva, E. Starling, C. Vander Velde, P. Vanlaer, D. Vannerom, R. Yonamine, F. Zenoni, T. Cornelis, D. Dobur, A. Fagot, M. Gul, I. Khvastunov, D. Poyraz, C. Roskas, S. Salva, M. Tytgat, W. Verbeke, N. Zaganidis, H. Bakhshiansohi, O. Bondu, S. Brochet, G. Bruno, C. Caputo, A. Caudron, P. David, S. De Visscher, C. Delaere, M. Delcourt, B. Francois, A. Giammanco, M. Komm, G. Krintiras, V. Lemaitre, A. Magitteri, A. Mertens, M. Musich, K. Piotrzkowski, L. Quertenmont, A. Saggio, M. Vidal Marono, S. Wertz, J. Zobec, W. L. Aldá Júnior, F. L. Alves, G. A. Alves, L. Brito, M. Correa Martins Junior, C. Hensel, A. Moraes, M. E. Pol, P. Rebello Teles, E. Belchior Batista Das Chagas, W. Carvalho, J. Chinellato, E. Coelho, E. M. Da Costa, G. G. Da Silveira, D. De Jesus Damiao, S. Fonseca De Souza, L. M. Huertas Guativa, H. Malbouisson, M. Melo De Almeida, C. Mora Herrera, L. Mundim, H. Nogima, L. J. Sanchez Rosas, A. Santoro, A. Sznajder, M. Thiel, E. J. Tonelli Manganote, F. Torres Da Silva De Araujo, A. Vilela Pereira, S. Ahuja, C. A. Bernardes, T. R. Fernandez Perez Tomei, E. M. Gregores, P. G. Mercadante, S. F. Novaes, Sandra S. Padula, D. Romero Abad, J. C. Ruiz Vargas, A. Aleksandrov, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Rodozov, M. Shopova, G. Sultanov, A. Dimitrov, L. Litov, B. Pavlov, P. Petkov, W. Fang, X. Gao, L. Yuan, M. Ahmad, J. G. Bian, G. M. Chen, H. S. Chen, M. Chen, Y. Chen, C. H. Jiang, D. Leggat, H. Liao, Z. Liu, F. Romeo, S. M. Shaheen, A. Spiezia, J. Tao, C. Wang, Z. Wang, E. Yazgan, H. Zhang, S. Zhang, J. Zhao, Y. Ban, G. Chen, J. Li, Q. Li, S. Liu, Y. Mao, S. J. Qian, D. Wang, Z. Xu, F. Zhang, Y. Wang, C. Avila, A. Cabrera, C. A. Carrillo Montoya, L. F. Chaparro Sierra, C. Florez, C. F. González Hernández, J. D. Ruiz Alvarez, M. A. Segura Delgado, B. Courbon, N. Godinovic, D. Lelas, I. Puljak, P. M. Ribeiro Cipriano, T. Sculac, Z. Antunovic, M. Kovac, V. Brigljevic, D. 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Srimanobhas, M. N. Bakirci, A. Bat, F. Boran, S. Damarseckin, Z. S. Demiroglu, C. Dozen, E. Eskut, S. Girgis, G. Gokbulut, Y. Guler, I. Hos, E. E. Kangal, O. Kara, U. Kiminsu, M. Oglakci, G. Onengut, K. Ozdemir, S. Ozturk, D. Sunar Cerci, U. G. Tok, H. Topakli, S. Turkcapar, I. S. Zorbakir, C. Zorbilmez, G. Karapinar, K. Ocalan, M. Yalvac, M. Zeyrek, E. Gülmez, M. Kaya, O. Kaya, S. Tekten, E. A. Yetkin, M. N. Agaras, S. Atay, A. Cakir, K. Cankocak, I. Köseoglu, B. Grynyov, L. Levchuk, F. Ball, L. Beck, J. J. Brooke, D. Burns, E. Clement, D. Cussans, O. Davignon, H. Flacher, J. Goldstein, G. P. Heath, H. F. Heath, L. Kreczko, D. M. Newbold, S. Paramesvaran, T. Sakuma, S. Seif El Nasr-storey, D. Smith, V. J. Smith, C. Brew, R. M. Brown, L. Calligaris, D. Cieri, D. J. A. Cockerill, J. A. Coughlan, K. Harder, S. Harper, J. Linacre, E. Olaiya, D. Petyt, C. H. Shepherd-Themistocleous, A. Thea, I. R. Tomalin, T. Williams, G. Auzinger, R. Bainbridge, J. Borg, S. Breeze, O. Buchmuller, A. Bundock, S. Casasso, M. Citron, D. Colling, L. Corpe, P. Dauncey, G. Davies, A. De Wit, M. Della Negra, R. Di Maria, A. Elwood, Y. Haddad, G. Hall, G. Iles, T. James, R. Lane, C. Laner, L. Lyons, A.-M. Magnan, S. Malik, L. Mastrolorenzo, T. Matsushita, J. Nash, A. Nikitenko, V. Palladino, M. Pesaresi, D. M. Raymond, A. Richards, A. Rose, E. Scott, C. Seez, A. Shtipliyski, S. Summers, A. Tapper, K. Uchida, M. Vazquez Acosta, T. Virdee, N. Wardle, D. Winterbottom, J. Wright, S. C. Zenz, J. E. Cole, P. R. Hobson, A. Khan, P. Kyberd, I. D. Reid, L. Teodorescu, S. Zahid, A. Borzou, K. Call, J. Dittmann, K. Hatakeyama, H. Liu, N. Pastika, C. Smith, R. Bartek, A. Dominguez, A. Buccilli, S. I. Cooper, C. Henderson, P. Rumerio, C. West, D. Arcaro, A. Avetisyan, T. Bose, D. Gastler, D. Rankin, C. Richardson, J. Rohlf, L. Sulak, D. Zou, G. Benelli, D. Cutts, A. Garabedian, M. Hadley, J. Hakala, U. Heintz, J. M. Hogan, K. H. M. Kwok, E. Laird, G. Landsberg, Z. Mao, M. Narain, J. Pazzini, S. Piperov, S. Sagir, R. Syarif, D. Yu, R. Band, C. Brainerd, R. Breedon, M. Calderon De La Barca Sanchez, M. Chertok, J. Conway, R. Conway, P. T. Cox, R. Erbacher, C. Flores, G. Funk, W. Ko, R. Lander, C. Mclean, M. Mulhearn, D. Pellett, J. Pilot, S. Shalhout, M. Shi, J. Smith, D. Stolp, K. Tos, M. Tripathi, M. Bachtis, C. Bravo, R. Cousins, A. Dasgupta, A. Florent, J. Hauser, M. Ignatenko, N. Mccoll, S. Regnard, D. Saltzberg, C. Schnaible, V. Valuev, E. Bouvier, K. Burt, R. Clare, J. Ellison, J. W. Gary, S. M. A. Ghiasi Shirazi, G. Hanson, J. Heilman, G. Karapostoli, E. Kennedy, F. Lacroix, O. R. Long, M. Olmedo Negrete, M. I. Paneva, W. Si, L. Wang, H. Wei, S. Wimpenny, B. R. Yates, J. G. Branson, S. Cittolin, M. Derdzinski, R. Gerosa, D. Gilbert, B. Hashemi, A. Holzner, D. Klein, G. Kole, V. Krutelyov, J. Letts, M. Masciovecchio, D. Olivito, S. Padhi, M. Pieri, M. Sani, V. Sharma, M. Tadel, A. Vartak, S. Wasserbaech, J. Wood, F. Würthwein, A. Yagil, G. Zevi Della Porta, N. Amin, R. Bhandari, J. Bradmiller-Feld, C. Campagnari, A. Dishaw, V. Dutta, M. Franco Sevilla, L. Gouskos, R. Heller, J. Incandela, A. Ovcharova, H. Qu, J. Richman, D. Stuart, I. Suarez, J. Yoo, D. Anderson, A. Bornheim, J. M. Lawhorn, H. B. Newman, T. Nguyen, C. Pena, M. Spiropulu, J. R. Vlimant, S. Xie, Z. Zhang, R. Y. Zhu, M. B. Andrews, T. Ferguson, T. Mudholkar, M. Paulini, J. Russ, M. Sun, H. Vogel, I. Vorobiev, M. Weinberg, J. P. Cumalat, W. T. Ford, F. Jensen, A. Johnson, M. Krohn, S. Leontsinis, T. Mulholland, K. Stenson, S. R. Wagner, J. Alexander, J. Chaves, J. Chu, S. Dittmer, K. Mcdermott, N. Mirman, J. R. Patterson, D. Quach, A. Rinkevicius, A. Ryd, L. Skinnari, L. Soffi, S. M. Tan, Z. Tao, J. Thom, J. Tucker, P. Wittich, M. Zientek, S. Abdullin, M. Albrow, M. Alyari, G. Apollinari, A. Apresyan, A. Apyan, L. A. T. Bauerdick, A. Beretvas, J. Berryhill, P. C. Bhat, G. Bolla, K. Burkett, J. N. Butler, A. Canepa, G. B. Cerati, H. W. K. Cheung, F. Chlebana, M. Cremonesi, J. Duarte, V. D. Elvira, J. Freeman, Z. Gecse, E. Gottschalk, L. Gray, D. Green, S. Grünendahl, O. Gutsche, R. M. Harris, S. Hasegawa, J. Hirschauer, Z. Hu, B. Jayatilaka, S. Jindariani, M. Johnson, U. Joshi, B. Klima, B. Kreis, S. Lammel, D. Lincoln, R. Lipton, M. Liu, T. Liu, R. Lopes De Sá, J. Lykken, K. Maeshima, N. Magini, J. M. Marraffino, D. Mason, P. McBride, P. Merkel, S. Mrenna, S. Nahn, V. O’Dell, K. Pedro, O. Prokofyev, G. Rakness, L. Ristori, B. Schneider, E. Sexton-Kennedy, A. Soha, W. J. Spalding, L. Spiegel, S. Stoynev, J. Strait, N. Strobbe, L. Taylor, S. Tkaczyk, N. V. Tran, L. Uplegger, E. W. Vaandering, C. Vernieri, M. Verzocchi, R. Vidal, M. Wang, H. A. Weber, A. Whitbeck, D. Acosta, P. Avery, P. Bortignon, D. Bourilkov, A. Brinkerhoff, A. Carnes, M. Carver, D. Curry, R. D. Field, I. K. Furic, S. V. Gleyzer, B. M. Joshi, J. Konigsberg, A. Korytov, K. Kotov, P. Ma, K. Matchev, H. Mei, G. Mitselmakher, K. Shi, D. Sperka, N. Terentyev, L. Thomas, J. Wang, S. Wang, J. Yelton, Y. R. Joshi, S. Linn, P. Markowitz, J. L. Rodriguez, A. Ackert, T. Adams, A. Askew, S. Hagopian, V. Hagopian, K. F. Johnson, T. Kolberg, G. Martinez, T. Perry, H. Prosper, A. Saha, A. Santra, R. Yohay, M. M. Baarmand, V. Bhopatkar, S. Colafranceschi, M. Hohlmann, D. Noonan, T. Roy, F. Yumiceva, M. R. Adams, L. Apanasevich, D. Berry, R. R. Betts, R. Cavanaugh, X. Chen, O. Evdokimov, C. E. Gerber, D. A. Hangal, D. J. Hofman, K. Jung, J. Kamin, I. D. Sandoval Gonzalez, M. B. Tonjes, H. Trauger, N. Varelas, H. Wang, Z. Wu, J. Zhang, B. Bilki, W. Clarida, K. Dilsiz, S. Durgut, R. P. Gandrajula, M. Haytmyradov, V. Khristenko, J.-P. Merlo, H. Mermerkaya, A. Mestvirishvili, A. Moeller, J. Nachtman, H. Ogul, Y. Onel, F. Ozok, A. Penzo, C. Snyder, E. Tiras, J. Wetzel, K. Yi, B. Blumenfeld, A. Cocoros, N. Eminizer, D. Fehling, L. Feng, A. V. Gritsan, P. Maksimovic, J. Roskes, U. Sarica, M. Swartz, M. Xiao, C. You, A. Al-bataineh, P. Baringer, A. Bean, S. Boren, J. Bowen, J. Castle, S. Khalil, A. Kropivnitskaya, D. Majumder, W. Mcbrayer, M. Murray, C. Royon, S. Sanders, E. Schmitz, J. D. Tapia Takaki, Q. Wang, A. Ivanov, K. Kaadze, Y. Maravin, A. Mohammadi, L. K. Saini, N. Skhirtladze, F. Rebassoo, D. Wright, C. Anelli, A. Baden, O. Baron, A. Belloni, S. C. Eno, Y. Feng, C. Ferraioli, N. J. Hadley, S. Jabeen, G. Y. Jeng, R. G. Kellogg, J. Kunkle, A. C. Mignerey, F. Ricci-Tam, Y. H. Shin, A. Skuja, S. C. Tonwar, D. Abercrombie, B. Allen, V. Azzolini, R. Barbieri, A. Baty, R. Bi, S. Brandt, W. Busza, I. A. Cali, M. D’Alfonso, Z. Demiragli, G. Gomez Ceballos, M. Goncharov, D. Hsu, M. Hu, Y. Iiyama, G. M. Innocenti, M. Klute, D. Kovalskyi, Y.-J. Lee, A. Levin, P. D. Luckey, B. Maier, A. C. Marini, C. Mcginn, C. Mironov, S. Narayanan, X. Niu, C. Paus, C. Roland, G. Roland, J. Salfeld-Nebgen, G. S. F. Stephans, K. Tatar, D. Velicanu, T. W. Wang, B. Wyslouch, A. C. Benvenuti, R. M. Chatterjee, A. Evans, P. Hansen, J. Hiltbrand, S. Kalafut, Y. Kubota, Z. Lesko, J. Mans, S. Nourbakhsh, N. Ruckstuhl, R. Rusack, J. Turkewitz, M. A. Wadud, J. G. Acosta, S. Oliveros, E. Avdeeva, K. Bloom, D. R. Claes, C. Fangmeier, F. Golf, R. Gonzalez Suarez, R. Kamalieddin, I. Kravchenko, J. Monroy, J. E. Siado, G. R. Snow, B. Stieger, J. Dolen, A. Godshalk, C. Harrington, I. Iashvili, D. Nguyen, A. Parker, S. Rappoccio, B. Roozbahani, G. Alverson, E. Barberis, C. Freer, A. Hortiangtham, A. Massironi, D. M. Morse, T. Orimoto, R. Teixeira De Lima, D. Trocino, T. Wamorkar, B. Wang, A. Wisecarver, D. Wood, O. Charaf, K. A. Hahn, N. Mucia, N. Odell, M. H. Schmitt, K. Sung, M. Trovato, M. Velasco, R. Bucci, N. Dev, M. Hildreth, K. Hurtado Anampa, C. Jessop, D. J. Karmgard, N. Kellams, K. Lannon, W. Li, N. Loukas, N. Marinelli, F. Meng, C. Mueller, Y. Musienko, M. Planer, A. Reinsvold, R. Ruchti, P. Siddireddy, G. Smith, S. Taroni, M. Wayne, A. Wightman, M. Wolf, A. Woodard, J. Alimena, L. Antonelli, B. Bylsma, L. S. Durkin, S. Flowers, B. Francis, A. Hart, C. Hill, W. Ji, B. Liu, W. Luo, B. L. Winer, H. W. Wulsin, S. Cooperstein, O. Driga, P. Elmer, J. Hardenbrook, P. Hebda, S. Higginbotham, A. Kalogeropoulos, D. Lange, J. Luo, D. Marlow, K. Mei, I. Ojalvo, J. Olsen, C. Palmer, P. Piroué, D. Stickland, C. Tully, S. Norberg, A. Barker, V. E. Barnes, S. Das, S. Folgueras, L. Gutay, M. K. Jha, M. Jones, A. W. Jung, A. Khatiwada, D. H. Miller, N. Neumeister, C. C. Peng, H. Qiu, J. F. Schulte, J. Sun, F. Wang, R. Xiao, W. Xie, T. Cheng, N. Parashar, J. Stupak, Z. Chen, K. M. Ecklund, S. Freed, F. J. M. Geurts, M. Guilbaud, M. Kilpatrick, B. Michlin, B. P. Padley, J. Roberts, J. Rorie, W. Shi, Z. Tu, J. Zabel, A. Zhang, A. Bodek, P. de Barbaro, R. Demina, Y. t. Duh, T. Ferbel, M. Galanti, A. Garcia-Bellido, J. Han, O. Hindrichs, A. Khukhunaishvili, K. H. Lo, P. Tan, M. Verzetti, R. Ciesielski, K. Goulianos, C. Mesropian, A. Agapitos, J. P. Chou, Y. Gershtein, T. A. Gómez Espinosa, E. Halkiadakis, M. Heindl, E. Hughes, S. Kaplan, R. Kunnawalkam Elayavalli, S. Kyriacou, A. Lath, R. Montalvo, K. Nash, M. Osherson, H. Saka, S. Salur, S. Schnetzer, D. Sheffield, S. Somalwar, R. Stone, S. Thomas, P. Thomassen, M. Walker, A. G. Delannoy, J. Heideman, G. Riley, K. Rose, S. Spanier, K. Thapa, O. Bouhali, A. Castaneda Hernandez, A. Celik, M. Dalchenko, M. De Mattia, A. Delgado, S. Dildick, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, R. Mueller, Y. Pakhotin, R. Patel, A. Perloff, L. Perniè, D. Rathjens, A. Safonov, A. Tatarinov, K. A. Ulmer, N. Akchurin, J. Damgov, F. De Guio, P. R. Dudero, J. Faulkner, E. Gurpinar, S. Kunori, K. Lamichhane, T. Libeiro, T. Mengke, S. Muthumuni, T. Peltola, S. Undleeb, I. Volobouev, S. Greene, A. Gurrola, R. Janjam, W. Johns, C. Maguire, A. Melo, H. Ni, K. Padeken, P. Sheldon, S. Tuo, J. Velkovska, Q. Xu, M. W. Arenton, P. Barria, B. Cox, R. Hirosky, M. Joyce, A. Ledovskoy, H. Li, C. Neu, T. Sinthuprasith, E. Wolfe, F. Xia, R. Harr, P. E. Karchin, N. Poudyal, J. Sturdy, P. Thapa, S. Zaleski, M. Brodski, J. Buchanan, C. Caillol, S. Dasu, L. Dodd, S. Duric, B. Gomber, M. Grothe, M. Herndon, A. Hervé, U. Hussain, P. Klabbers, A. Lanaro, A. Levine, K. Long, R. Loveless, T. Ruggles, A. Savin, N. Smith, W. H. Smith, D. Taylor, N. Woods, and CMS Collaboration
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Published: 2023
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15. Gene regulatory network reconfiguration in direct lineage reprogramming

Author: Kenji Kamimoto, Mohd Tayyab Adil, Kunal Jindal, Christy M. Hoffmann, Wenjun Kong, Xue Yang, and Samantha A. Morris
Subjects: gene perturbation simulation, cell fate prediction, gene regulatory networks, machine learning, direct lineage reprogramming, single-cell analysis, Medicine (General), R5-920, Biology (General), QH301-705.5
Abstract: Summary: In direct lineage conversion, transcription factor (TF) overexpression reconfigures gene regulatory networks (GRNs) to reprogram cell identity. We previously developed CellOracle, a computational method to infer GRNs from single-cell transcriptome and epigenome data. Using inferred GRNs, CellOracle simulates gene expression changes in response to TF perturbation, enabling in silico interrogation of network reconfiguration. Here, we combine CellOracle analysis with lineage tracing of fibroblast to induced endoderm progenitor (iEP) conversion, a prototypical direct reprogramming paradigm. By linking early network state to reprogramming outcome, we reveal distinct network configurations underlying successful and failed fate conversion. Via in silico simulation of TF perturbation, we identify new factors to coax cells into successfully converting their identity, uncovering a central role for the AP-1 subunit Fos with the Hippo signaling effector, Yap1. Together, these results demonstrate the efficacy of CellOracle to infer and interpret cell-type-specific GRN configurations, providing new mechanistic insights into lineage reprogramming.
Published: 2023
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16. Method for in-field texture analysis of sugar beet roots using a handheld penetrometer

Author: William English, Joakim Ekelöf, Françoise Vancutsem, Martijn Leijdekkers, Gunnar Kleuker, and Christa M. Hoffmann
Subjects: mechanical properties, textural properties, firmness, pre-harvest measurement, post-harvest losses, Plant culture, SB1-1110
Abstract: Methodology for analysing textural properties of sugar beet roots in the laboratory has previously been established. It has been shown to be reliable and of value in exploring relationships between textural properties, damage rates, and storability of varieties. In this paper, a methodology for the assessment of textural properties in-field, prior to harvest, using an inexpensive handheld penetrometer is examined. Three sugar beet varieties were grown in Belgium, the Netherlands, and Sweden during 2019. Textural properties were assessed in-field with the handheld penetrometer 2, 1 and 0 months prior to harvest, and with the laboratory penetrometer directly after harvest. Comparison of the results showed generally strong correlations. A power analysis suggests a difference in mean Handheld Pressure of 0.10 MPa could be found significant within a large trial with a block design. The reliability of the handheld penetrometer was further assessed in the Swedish national variety trials over three years (2019-2021). Correlation coefficients of 0.86 and 0.94 were found between mean Handheld Pressure for 2019 and 2020, and 2020 and 2021 respectively. The handheld penetrometer can be applied as an economic means of quantifying differences in textural properties of sugar beet varieties. Clear operating procedure and training must exist.
Published: 2022
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17. Transverse-spin-dependent azimuthal asymmetries of pion and kaon pairs produced in muon-proton and muon-deuteron semi-inclusive deep inelastic scattering

Author: G.D. Alexeev, M.G. Alexeev, C. Alice, A. Amoroso, V. Andrieux, V. Anosov, K. Augsten, W. Augustyniak, C.D.R. Azevedo, B. Badelek, J. Barth, R. Beck, Y. Bedfer, J. Bernhard, M. Bodlak, F. Bradamante, C. Braun, A. Bressan, V.E. Burtsev, W.-C. Chang, C. Chatterjee, M. Chiosso, A.G. Chumakov, S.-U. Chung, A. Cicuttin, P.M.M. Correia, M.L. Crespo, D. D'Ago, S. Dalla Torre, S.S. Dasgupta, S. Dasgupta, F. Del Carro, I. Denisenko, O.Yu. Denisov, S.V. Donskov, N. Doshita, Ch. Dreisbach, W. Dünnweber, R.R. Dusaev, D. Ecker, A. Efremov, C. Elia, D. Eremeev, P. Faccioli, M. Faessler, M. Finger, M. Finger, jr., H. Fischer, K.J. Flöthner, W. Florian, J.M. Friedrich, V. Frolov, L.G. Garcia Ordòñez, F. Gautheron, O.P. Gavrichtchouk, S. Gerassimov, J. Giarra, D. Giordano, M. Gorzellik, A. Grasso, A. Gridin, M. Grosse Perdekamp, B. Grube, M. Grüner, A. Guskov, D. von Harrach, M. Hoffmann, N. Horikawa, N. d'Hose, C.-Y. Hsieh, S. Huber, S. Ishimoto, A. Ivanov, T. Iwata, M. Jandek, V. Jary, R. Joosten, E. Kabuß, F. Kaspar, A. Kerbizi, B. Ketzer, A. Khatun, G.V. Khaustov, F. Klein, J.H. Koivuniemi, V.N. Kolosov, K. Kondo Horikawa, I. Konorov, V.F. Konstantinov, A.M. Korzenev, A.M. Kotzinian, O.M. Kouznetsov, A. Koval, Z. Kral, F. Krinner, F. Kunne, K. Kurek, R.P. Kurjata, A. Kveton, K. Lavickova, S. Levorato, Y.-S. Lian, J. Lichtenstadt, P.-J. Lin, R. Longo, V.E. Lyubovitskij, A. Maggiora, A. Magnon, N. Makins, N. Makke, G.K. Mallot, A. Maltsev, S.A. Mamon, A. Martin, J. Marzec, J. Matoušek, T. Matsuda, G. Mattson, C. Menezes Pires, F. Metzger, M. Meyer, W. Meyer, Yu.V. Mikhailov, M. Mikhasenko, E. Mitrofanov, D. Miura, Y. Miyachi, R. Molina, A. Moretti, A. Nagaytsev, D. Neyret, M. Niemiec, J. Nový, W.-D. Nowak, G. Nukazuka, A.G. Olshevsky, M. Ostrick, D. Panzieri, B. Parsamyan, S. Paul, H. Pekeler, J.-C. Peng, G. Pesaro, M. Pešek, D.V. Peshekhonov, M. Pešková, S. Platchkov, J. Pochodzalla, V.A. Polyakov, M. Quaresma, C. Quintans, G. Reicherz, C. Riedl, D.I. Ryabchikov, A. Rychter, A. Rymbekova, V.D. Samoylenko, A. Sandacz, S. Sarkar, I.A. Savin, G. Sbrizzai, P. Schiavon, H. Schmieden, A. Selyunin, K. Sharko, L. Sinha, M. Slunecka, F. Sozzi, D. Spülbeck, A. Srnka, M. Stolarski, O. Subrt, M. Sulc, H. Suzuki, S. Tessaro, F. Tessarotto, A. Thiel, J. Tomsa, F. Tosello, A. Townsend, T. Triloki, V. Tskhay, B. Valinoti, B.M. Veit, J.F.C.A. Veloso, B. Ventura, M. Virius, M. Wagner, S. Wallner, K. Zaremba, M. Zavertyaev, M. Zemko, E. Zemlyanichkina, and M. Ziembicki
Subjects: SIDIS, Di-hadron, Spin, Fragmentation, Transversity, Collins effect, Physics, QC1-999
Abstract: A set of measurements of azimuthal asymmetries in the production of pairs of identified hadrons in deep-inelastic scattering of muons on transversely polarised 6LiD (deuteron) and NH3 (proton) targets is presented. All available data collected in the years 2003–2004 and 2007/2010 with the COMPASS spectrometer using a muon beam of 160GeV/c at the CERN SPS were analysed. The asymmetries provide access to the transversity distribution functions via a fragmentation function that in principle may be independently obtained from e+e− annihilation data. Results are presented, discussed and compared to existing measurements as well as to model predictions. Asymmetries of π+π− pairs measured with the proton target as a function of the Bjorken scaling variable are sizeable in the range x>0.032, indicating non-vanishing transversity distribution and di-hadron interference fragmentation functions. As already pointed out by several authors, the small asymmetries of π+π− measured on the 6LiD target can be interpreted as indication for a cancellation of u and d-quark transversity distributions.
Published: 2023
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18. Study of Salmonella spp. from Cage Papers Belonging to Pet Birds in an Argentinean Canary Breeder Championship

Author: Dante J. Bueno, Francisco I. Rodríguez, Luciana C. Machado, Mario A. Soria, Francisco Procura, Silvana C. Gómez, Teresa M. Hoffmann, Andrea Alcain, María I. Caffer, Juan D. Latorre, and Javier O. Quintar
Subjects: canary, Salmonella, bird fairs, Argentina, antibiotic, disinfectant, Veterinary medicine, SF600-1100, Zoology, QL1-991
Abstract: Birds, including canaries and other birds, have become increasingly popular as pets. Bird fairs, where breeders gather and show their production in a championship setting, present a setting for possible Salmonella spp. contamination and transmission. Therefore, this study estimated the rate of Salmonella spp. isolation from cage papers, located in the bottom of cages of exotic pet birds, including canaries. Collected Salmonella isolates were used to determine the antimicrobial resistance profile to 52 antibiotics and 17 commercial disinfectants, based on pure or a mixture of acids, alcohols, aldehydes, alkalis, halogens, peroxygen, and quaternary ammonium compounds. The samples consisted of 774 cage papers taken in the 2015 Argentinean canary breeder championship, pooling three cage papers into one sterile sampling bag. Only one pool of the cage papers was positive for Salmonella spp. (0.4%), which belonged to the sample from three frill canary cages. Two strains of Salmonella serotype Glostrup were isolated, which were only resistant to sulfonamides and erythromycin and sensitive to alkali-based product PL301 AS. Although the rate of Salmonella spp. isolation from cage papers in an Argentinean canary breeder championship is low, it should not be discounted because Salmonella ser. Glostrup can be a source of human Salmonella outbreaks and they show high resistance to disinfecting products.
Published: 2024
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19. Molecular Dynamics Study of the Green Solvent Polyethylene Glycol with Water Impurities

Author: Markus M. Hoffmann, Matthew D. Too, Nathaniel A. Paddock, Robin Horstmann, Sebastian Kloth, Michael Vogel, and Gerd Buntkowsky
Subjects: polyethylene glycol, ethylene glycol oligomers, water impurity, hydrogen bonding, radial distribution functions, density, Organic chemistry, QD241-441
Abstract: Polyethylene glycol (PEG) is one of the environmentally benign solvent options for green chemistry. It readily absorbs water when exposed to the atmosphere. The Molecular Dynamics (MD) simulations of PEG200, a commercial mixture of low molecular weight polyethyelene glycol oligomers, as well as di-, tetra-, and hexaethylene glycol are presented to study the effect of added water impurities up to a weight fraction of 0.020, which covers the typical range of water impurities due to water absorption from the atmosphere. Each system was simulated a total of four times using different combinations of two force fields for the water (SPC/E and TIP4P/2005) and two force fields for the PEG and oligomer (OPLS-AA and modified OPLS-AA). The observed trends in the effects of water addition were qualitatively quite robust with respect to these force field combinations and showed that the water does not aggregate but forms hydrogen bonds at most between two water molecules. In general, the added water causes overall either no or very small and nuanced effects in the simulation results. Specifically, the obtained water RDFs are mostly identical regardless of the water content. The added water reduces oligomer hydrogen bonding interactions overall as it competes and forms hydrogen bonds with the oligomers. The loss of intramolecular oligomer hydrogen bonding is in part compensated by oligomers switching from inter- to intramolecular hydrogen bonding. The interplay of the competing hydrogen bonding interactions leads to the presence of shallow extrema with respect to the water weight fraction dependencies for densities, viscosities, and self-diffusion coefficients, in contrast to experimental measurements, which show monotonous dependencies. However, these trends are very small in magnitude and thus confirm the experimentally observed insensitivity of these physical properties to the presence of water impurities.
Published: 2024
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20. Beam-based commissioning of a novel X-band transverse deflection structure with variable polarization

Author: P. González Caminal, F. Christie, R. D’Arcy, S. M. Jaster-Merz, R. Assmann, F. Burkart, B. Conrad, H. Dinter, M. Foese, J. Herrmann, M. Hoffmann, M. Hüning, R. Jonas, O. Krebs, S. Lederer, B. Marchetti, D. Marx, J. Mueller, J. Osterhoff, I. Peperkorn, M. Reukauff, H. Schlarb, S. Schreiber, G. Tews, T. Vinatier, M. Vogt, A. de Z. Wagner, S. Wesch, P. Craievich, M. Bopp, H.-H. Braun, A. Citterio, R. Fortunati, R. Ganter, T. Kleeb, F. Marcellini, M. Pedrozzi, E. Prat, S. Reiche, K. Rolli, R. Sieber, A. Grudiev, W. L. Millar, N. Catalan-Lasheras, G. McMonagle, S. Pitman, V. del Pozo Romano, K. T. Szypula, and W. Wuensch
Subjects: Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Longitudinal electron-beam diagnostics play a critical role in the operation and control of x-ray free-electron lasers, which rely on parameters such as the current profile, the longitudinal phase space, or the slice emittance of the particle distribution. On the one hand, the femtosecond-scale electron bunches produced at these facilities impose stringent requirements on the resolution achievable with the diagnostics. On the other, research and development of novel accelerator technologies such as beam-driven plasma-wakefield accelerators (PWFA) demand unprecedented capabilities to resolve the centroid offsets in the full transverse plane along the longitudinal bunch coordinate. We present the beam-based commissioning of an advanced X-band transverse-deflection rf structure (TDS) system with the new feature of providing variable polarization of the deflecting force: the PolariX-TDS. By means of a comprehensive campaign of measurements conducted with the prototype, key parameters of the rf performance of the system are validated and a phase-space characterization of an electron bunch is accomplished with a time resolution of 3.3 fs. Furthermore, an analysis of second-order effects induced on the bunch from its passage through the PolariX-TDS is presented.
Published: 2024
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21. Obesity alters the mouse endometrial transcriptome in a cell context-dependent manner

Author: Mike R. Wilson, Hilary Skalski, Jake J. Reske, Marc Wegener, Marie Adams, Galen Hostetter, Hanne M. Hoffmann, Jamie J. Bernard, Victoria L. Bae-Jump, Jose M. Teixeira, and Ronald L. Chandler
Subjects: Uterus, Obesity, Endometrium, Epithelium, Stroma, Gynecology and obstetrics, RG1-991, Reproduction, QH471-489
Abstract: Abstract Obesity impacts fertility and is positively correlated with endometrial hyperplasia and endometrial cancer occurrence. Endometrial epithelia often harbor disease driver-mutations, while endometrial stroma are highly regulative of neighboring epithelia. Here, we sought to determine distinct transcriptome changes occurring in individual cell types in the obese mouse uterus. Outbred CD-1 mice were fed high-fat or control diets for 18 weeks, estrous cycle staged, and endometrial epithelia, macrophages, and stroma isolated for transcriptomic analysis. High-fat diet mice displayed increased body mass and developed glucose intolerance, hyperinsulinemia, and fatty liver. Obese mouse epithelia displayed differential gene expression for genes related to innate immunity and leukocyte chemotaxis. The obese mouse stroma differentially expressed factors related to circadian rhythm, and expression of these genes correlated with glucose tolerance or body mass. We observed correlations between F4/80 + macrophage numbers, Cleaved Caspase 3 (CC3) apoptosis marker staining and glucose intolerance among obese mice, including a subgroup of obese mice with high CC3 + luminal epithelia. This subgroup displayed differential gene expression among all cell types, with pathways related to immune escape in epithelia and macrophages, while the stroma dysregulated pathways related to regulation of epithelia. These results suggest an important role for differential response of both the epithelia and stroma in their response to obesity, while macrophages are dysregulated in the context of apoptotic epithelia. The obesity-related gene expression programs in cells within the uterine microenvironment may influence the ability of the endometrium to function during pregnancy and influence disease pathogenesis.
Published: 2022
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22. Co-alterations of circadian clock gene transcripts in human placenta in preeclampsia

Author: Guoli Zhou, Emily Winn, Duong Nguyen, Eric P. Kasten, Margaret G. Petroff, and Hanne M. Hoffmann
Subjects: Medicine, Science
Abstract: Abstract Pre-eclampsia (PE) is a hypertensive condition that occurs during pregnancy and complicates up to 4% of pregnancies. PE exhibits several circadian-related characteristics, and the placenta possesses a functioning molecular clock. We examined the associations of 17 core circadian gene transcripts in placenta with PE vs. non-PE (a mixture of pregnant women with term, preterm, small-for-gestational-age, or chorioamnionitis) using two independent gene expression datasets: GSE75010-157 (80 PE vs. 77 non-PE) and GSE75010-173 (77 PE and 96 non-PE). We found a robust difference in circadian gene expression between PE and non-PE across the two datasets, where CRY1 mRNA increases and NR1D2 and PER3 transcripts decrease in PE placenta. Gene set variation analysis revealed an interplay between co-alterations of circadian clock genes and PE with altered hypoxia, cell migration/invasion, autophagy, and membrane trafficking pathways. Using human placental trophoblast HTR-8 cells, we show that CRY1/2 and NR1D1/2 regulate trophoblast migration. A subgroup study including only term samples demonstrated that CLOCK, NR1D2, and PER3 transcripts were simultaneously decreased in PE placenta, a finding supported by CLOCK protein downregulation in an independent cohort of human term PE placenta samples. These findings provide novel insights into the roles of the molecular clock in the pathogenesis of PE.
Published: 2022
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23. Viral suppression and retention in HIV care during the postpartum period among women living with HIV: a longitudinal multicenter cohort studyResearch in context

Author: Paolo Paioni, Karoline Aebi-Popp, Begoña Martinez de Tejada, Christoph Rudin, Enos Bernasconi, Dominique L. Braun, Roger Kouyos, Noémie Wagner, Pierre Alex Crisinel, Sabine Güsewell, Katharine E.A. Darling, Andrea Duppenthaler, Marc Baumann, Christian Polli, Tina Fischer, Christian R. Kahlert, I. Abela, K. Aebi-Popp, A. Anagnostopoulos, M. Battegay, M. Baumann, E. Bernasconi, D.L. Braun, H.C. Bucher, A. Calmy, M. Cavassini, A. Ciuffi, P.A. Crisinel, K. Darling, A. Duppenthaler, G. Dollenmaier, M. Egger, L. Elzi, J. Fehr, J. Fellay, K. Francini, H. Furrer, C.A. Fux, H.F. Günthard, A. Hachfeld, D. Haerry, B. Hasse, H.H. Hirsch, M. Hoffmann, I. Hösli, M. Huber, D. Jackson-Perry, C.R. Kahlert, L. Kaiser, E. Kapfhammer, O. Keiser, T. Klimkait, M. Kohns, L. Kottanattu, R.D. Kouyos, H. Kovari, K. Kusejko, N. Labhardt, B. Martinez de Tejada, C. Marzolini, K.J. Metzner, N. Müller, J. Nemeth, D. Nicca, J. Notter, P. Paioni, G. Pantaleo, M. Perreau, Ch Polli, A. Rauch, L. Salazar-Vizcaya, P. Schmid, R. Speck, M. Stöckle, P. Tarr, M. Thanh Lecompte, A. Trkola, N. Wagner, G. Wandeler, M. Weisser, and S. Yerly
Subjects: Postpartum period, Retention in HIV care, Postpartum HIV care engagement, Viral suppression, Breastfeeding, Infant follow-up, Public aspects of medicine, RA1-1270
Abstract: Summary: Background: Low rates of postnatal retention in HIV care and viral suppression have been reported in women living with HIV (WLWH) despite viral suppression at delivery. At the same time, postpartum follow-up is of crucial importance in light of the increasing support offered in many resource-rich countries including Switzerland to WLWH choosing to breastfeed their infant, if optimal scenario criteria are met. Methods: We longitudinally investigated retention in HIV care, viral suppression, and infant follow-up in a prospective multicentre HIV cohort study of WLWH in the optimal scenario who had a live birth between January 2000 and December 2018. Risk factors for adverse outcomes in the first year postpartum were assessed using logistic and proportional hazard models. Findings: Overall, WLWH were retained in HIV care for at least six months after 94.2% of the deliveries (694/737). Late start of combination antiretroviral therapy (cART) during the third trimester was found to be the main risk factor for failure of retention in HIV care (crude odds ratio [OR] 3.91; 95% confidence interval [CI], 1.50–10.22; p = 0.005). Among mothers on cART until at least one year after delivery, 4.4% (26/591) experienced viral failure, with illicit drugs use being the most important risk factor (hazard ratio [HR], 13.2; 95% CI, 2.35–73.6; p = 0.003). The main risk factors for not following the recommendations regarding infant follow-up was maternal depression (OR, 3.52; 95% CI, 1.18–10.52; p = 0.024). Interpretation: Although the results are reassuring, several modifiable risk factors for adverse postpartum outcome, such as late treatment initiation and depression, were identified. These factors should be addressed in HIV care of all WLWH, especially those opting to breastfeed in resource-rich countries. Funding: This study has been financed within the framework of the Swiss HIV Cohort Study, supported by the Swiss National Science Foundation (grant #201369), by SHCS project 850 and by the SHCS research foundation.
Published: 2023
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24. Collins and Sivers transverse-spin asymmetries in inclusive muoproduction of ρ0 mesons

Author: G.D. Alexeev, M.G. Alexeev, C. Alice, A. Amoroso, V. Andrieux, V. Anosov, K. Augsten, W. Augustyniak, C.D.R. Azevedo, B. Badelek, J. Barth, R. Beck, Y. Bedfer, J. Bernhard, M. Bodlak, F. Bradamante, A. Bressan, V.E. Burtsev, W.-C. Chang, C. Chatterjee, M. Chiosso, A.G. Chumakov, S.-U. Chung, A. Cicuttin, P.M.M. Correia, M.L. Crespo, D. D'Ago, S. Dalla Torre, S.S. Dasgupta, S. Dasgupta, F. Del Carro, I. Denisenko, O.Yu. Denisov, S.V. Donskov, N. Doshita, Ch. Dreisbach, W. Dünnweber, R.R. Dusaev, D. Ecker, A. Efremov, C. Elia, D. Eremeev, P. Faccioli, M. Faessler, M. Finger, M. Finger, jr., H. Fischer, K.J. Flöthner, W. Florian, J.M. Friedrich, V. Frolov, L.G. Garcia Ordòñez, F. Gautheron, O.P. Gavrichtchouk, S. Gerassimov, J. Giarra, D. Giordano, M. Gorzellik, A. Grasso, A. Gridin, M. Grosse Perdekamp, B. Grube, M. Grüner, A. Guskov, D. von Harrach, M. Hoffmann, N. Horikawa, N. d'Hose, C.-Y. Hsieh, S. Huber, S. Ishimoto, A. Ivanov, T. Iwata, M. Jandek, V. Jary, R. Joosten, E. Kabuß, F. Kaspar, A. Kerbizi, B. Ketzer, A. Khatun, G.V. Khaustov, F. Klein, J.H. Koivuniemi, V.N. Kolosov, K. Kondo Horikawa, I. Konorov, V.F. Konstantinov, A.M. Korzenev, A.M. Kotzinian, O.M. Kouznetsov, A. Koval, Z. Kral, F. Krinner, F. Kunne, K. Kurek, R.P. Kurjata, A. Kveton, K. Lavickova, S. Levorato, Y.-S. Lian, J. Lichtenstadt, P.-J. Lin, R. Longo, V.E. Lyubovitskij, A. Maggiora, A. Magnon, N. Makins, N. Makke, G.K. Mallot, A. Maltsev, S.A. Mamon, A. Martin, J. Marzec, J. Matoušek, T. Matsuda, G. Mattson, C. Menezes Pires, F. Metzger, M. Meyer, W. Meyer, Yu.V. Mikhailov, M. Mikhasenko, E. Mitrofanov, D. Miura, Y. Miyachi, R. Molina, A. Moretti, A. Nagaytsev, C. Naim, D. Neyret, J. Nový, W.-D. Nowak, G. Nukazuka, A.G. Olshevsky, M. Ostrick, D. Panzieri, B. Parsamyan, S. Paul, H. Pekeler, J.-C. Peng, M. Pešek, D.V. Peshekhonov, M. Pešková, S. Platchkov, J. Pochodzalla, V.A. Polyakov, M. Quaresma, C. Quintans, G. Reicherz, C. Riedl, T. Rudnicki, D.I. Ryabchikov, A. Rychter, A. Rymbekova, V.D. Samoylenko, A. Sandacz, S. Sarkar, I.A. Savin, G. Sbrizzai, H. Schmieden, A. Selyunin, K. Sharko, L. Sinha, M. Slunecka, F. Sozzi, D. Spülbeck, A. Srnka, M. Stolarski, O. Subrt, M. Sulc, H. Suzuki, S. Tessaro, F. Tessarotto, A. Thiel, J. Tomsa, F. Tosello, A. Townsend, T. Triloki, V. Tskhay, B. Valinoti, B.M. Veit, J.F.C.A. Veloso, B. Ventura, M. Virius, M. Wagner, S. Wallner, K. Zaremba, M. Zavertyaev, M. Zemko, E. Zemlyanichkina, and M. Ziembicki
Subjects: SIDIS, Spin, Fragmentation, Collins asymmetry, Sivers asymmetry, Physics, QC1-999
Abstract: The production of vector mesons in deep inelastic scattering is an interesting yet scarcely explored channel to study the transverse spin structure of the nucleon and the spin-dependence of fragmentation. The COMPASS collaboration has performed the first measurement of the Collins and Sivers asymmetries for inclusively produced ρ0 mesons. The analysis is based on the data set collected in deep inelastic scattering in 2010 using a 160GeV/c μ+ beam impinging on a transversely polarized NH3 target. The ρ0 mesons are selected from oppositely charged hadron pairs, and the asymmetries are extracted as a function of the Bjorken-x variable, the transverse momentum of the pair and the fraction of the energy z carried by the pair. Indications for positive Collins and Sivers asymmetries are observed.
Published: 2023
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25. Long-term functional and structural outcomes in X-linked retinoschisis: implications for clinical trials

Author: Beau J. Fenner, Jonathan F. Russell, Arlene V. Drack, Alina V. Dumitrescu, Elliott H. Sohn, Stephen R. Russell, H. Culver Boldt, Louisa M. Affatigato, Jeremy M. Hoffmann, Jeaneen L. Andorf, Edwin M. Stone, and Ian C. Han
Subjects: retina, genetics, inherited eye disease, retinoschisis, retinal detachment, gene therapy, Medicine (General), R5-920
Abstract: IntroductionX-linked retinoschisis (XLRS) is an inherited retinal disease (IRD) caused by pathogenic mutations in the retinoschisin gene, RS1. Affected individuals develop retinal layer separation, leading to loss of visual acuity (VA). Several XLRS gene therapy trials have been attempted but none have met their primary endpoints. An improved understanding of XLRS natural history and clinical outcomes may better inform future trials. Here, we report the long-term functional and structural outcomes of XLRS and the relevance of RS1 genotypes to the visual prognosis of affected individuals.MethodsA retrospective chart review of patients with molecularly confirmed X-linked retinoschisis was performed. Functional and structural outcomes, and RS1 genotype data, were included for analysis.ResultsFifty-two patients with XLRS from 33 families were included in the study. Median age at symptom onset was 5 years (range 0–49) and median follow-up was 5.7 years (range 0.1–56.8). Macular retinoschisis occurred in 103 of 104 eyes (99.0%), while peripheral retinoschisis occurred in 48 of 104 eyes (46.2%), most often in the inferotemporal quadrant (40.4%). Initial and final VA were similar (logMAR 0.498 vs. 0.521; p = 0.203). Fifty of 54 eyes (92.6%) developed detectable outer retinal loss by age 20, and 29 of 66 eyes (43.9%) had focal or diffuse outer retinal atrophy (ORA) by age 40. ORA but not central subfield thickness (CST) was associated with reduced VA. Inter-eye correlation was modest for VA (r-squared = 0.03; p = 0.08) and CST (r-squared = 0.15; p = 0.001). Carbonic anhydrase inhibitors (CAIs) improved CST (p = 0.026), but not VA (p = 0.380). Eight of 104 eyes (7.7%) had XLRS-related retinal detachment (RD), which was associated with poorer outcomes compared to eyes without RD (median final VA 0.875 vs. 0.487; p
Published: 2023
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26. Astronomy in Culture -- Cultures of Astronomy. Astronomie in der Kultur -- Kulturen der Astronomie.: Featuring the Proceedings of the Splinter Meeting at the Annual Conference of the Astronomische Gesellschaft, Sept. 14–16, 2021. Nuncius Hamburgensis; Vol. 57.

Author: Gudrun Wolfschmidt, Susanne M. Hoffmann, Susanne M. Hoffmann, Gudrun Wolfschmidt
Published: 2022

27. The ST22 chronology for the Skytrain Ice Rise ice core – Part 1: A stratigraphic chronology of the last 2000 years

Author: H. M. Hoffmann, M. M. Grieman, A. C. F. King, J. A. Epifanio, K. Martin, D. Vladimirova, H. V. Pryer, E. Doyle, A. Schmidt, J. D. Humby, I. F. Rowell, C. Nehrbass-Ahles, E. R. Thomas, R. Mulvaney, and E. W. Wolff
Subjects: Environmental pollution, TD172-193.5, Environmental protection, TD169-171.8, Environmental sciences, GE1-350
Abstract: A new ice core was drilled in West Antarctica on Skytrain Ice Rise in field season 2018/2019. This 651 m ice core is one of the main targets of the WACSWAIN (WArm Climate Stability of the West Antarctic ice sheet in the last INterglacial) project. A present-day accumulation rate of 13.5 cm w.e. yr−1 was derived. Although the project mainly aims to investigate the last interglacial (115–130 ka), a robust chronology period covering the recent past is needed to constrain the age models for the deepest ice. Additionally, this time period is important for understanding current climatic changes in the West Antarctic region. Here, we present a stratigraphic chronology for the top 184.14 m of the Skytrain ice core based on absolute age tie points interpolated using annual layer counting encompassing the last 2000 years of climate history. Together with a model-based depth–age relationship of the deeper part of the ice core, this will form the ST22 chronology. The chemical composition, dust content, liquid conductivity, water isotope concentration and methane content of the whole core was analysed via continuous flow analysis (CFA) at the British Antarctic Survey. Annual layer counting was performed by manual counting of seasonal variations in mainly the sodium and calcium records. This counted chronology was informed and anchored by absolute age tie points, namely, the tritium peak (1965 CE) and six volcanic eruptions. Methane concentration variations were used to further constrain the counting error. A minimal error of ±1 year at the tie points was derived, accumulating to ± 5 %–10 % of the age in the unconstrained sections between tie points. This level of accuracy enables data interpretation on at least decadal timescales and provides a solid base for the dating of deeper ice, which is the second part of the chronology.
Published: 2022
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28. Erratum to: Measurement of exclusive $$\Upsilon $$ Υ photoproduction from protons in pPb collisions at $${\sqrt{{s_{\mathrm{NN}}}}} = 5.02\,\hbox {TeV}$$ s NN = 5.02 TeV

Author: A. M. Sirunyan, A. Tumasyan, W. Adam, F. Ambrogi, E. Asilar, T. Bergauer, J. Brandstetter, E. Brondolin, M. Dragicevic, J. Erö, A. Escalante Del Valle, M. Flechl, M. Friedl, R. Frühwirth, V. M. Ghete, J. Grossmann, J. Hrubec, M. Jeitler, A. König, N. Krammer, I. Krätschmer, D. Liko, T. Madlener, I. Mikulec, E. Pree, N. Rad, H. Rohringer, J. Schieck, R. Schöfbeck, M. Spanring, D. Spitzbart, A. Taurok, W. Waltenberger, J. Wittmann, C.-E. Wulz, M. Zarucki, V. Chekhovsky, V. Mossolov, J. Suarez Gonzalez, E. A. De Wolf, D. Di Croce, X. Janssen, J. Lauwers, M. Pieters, M. Van De Klundert, H. Van Haevermaet, P. Van Mechelen, N. Van Remortel, S. Abu Zeid, F. Blekman, J. D’Hondt, I. De Bruyn, J. De Clercq, K. Deroover, G. Flouris, D. Lontkovskyi, S. Lowette, I. Marchesini, S. Moortgat, L. Moreels, Q. Python, K. Skovpen, S. Tavernier, W. Van Doninck, P. Van Mulders, I. Van Parijs, D. Beghin, B. Bilin, H. Brun, B. Clerbaux, G. De Lentdecker, H. Delannoy, B. Dorney, G. Fasanella, L. Favart, R. Goldouzian, A. Grebenyuk, A. K. Kalsi, T. Lenzi, J. Luetic, T. Seva, E. Starling, C. Vander Velde, P. Vanlaer, D. Vannerom, R. Yonamine, T. Cornelis, D. Dobur, A. Fagot, M. Gul, I. Khvastunov, D. Poyraz, C. Roskas, D. Trocino, M. Tytgat, W. Verbeke, B. Vermassen, M. Vit, N. Zaganidis, H. Bakhshiansohi, O. Bondu, S. Brochet, G. Bruno, C. Caputo, A. Caudron, P. David, S. De Visscher, C. Delaere, M. Delcourt, B. Francois, A. Giammanco, G. Krintiras, V. Lemaitre, A. Magitteri, A. Mertens, M. Musich, K. Piotrzkowski, L. Quertenmont, A. Saggio, M. Vidal Marono, S. Wertz, J. Zobec, W. L. Aldá Júnior, F. L. Alves, G.A. Alves, L. Brito, G. Correia Silva, C. Hensel, A. Moraes, M. E. Pol, P. Rebello Teles, E. Belchior Batista Das Chagas, W. Carvalho, J. Chinellato, E. Coelho, E. M. Da Costa, G.G. Da Silveira, D. De Jesus Damiao, S. Fonseca De Souza, H. Malbouisson, M. Medina Jaime, M. Melo De Almeida, C. Mora Herrera, L. Mundim, H. Nogima, L. J. Sanchez Rosas, A. Santoro, A. Sznajder, M. Thiel, E. J. Tonelli Manganote, F. Torres Da Silva De Araujo, A. Vilela Pereira, S. Ahuja, C. A. Bernardes, L. Calligaris, T. R. Fernandez Perez Tomei, E. M. Gregores, P. G. Mercadante, S. F. Novaes, Sandra S. Padula, D. Romero Abad, J. C. Ruiz Vargas, A. Aleksandrov, R. Hadjiiska, P. Iaydjiev, A. Marinov, M. Misheva, M. Rodozov, M. Shopova, G. Sultanov, A. Dimitrov, L. Litov, B. Pavlov, P. Petkov, W. Fang, X. Gao, L. Yuan, M. Ahmad, J. G. Bian, G. M. Chen, H. S. Chen, M. Chen, Y. Chen, C. H. Jiang, D. Leggat, H. Liao, Z. Liu, F. Romeo, S. M. Shaheen, A. Spiezia, J. Tao, C. Wang, Z. Wang, E. Yazgan, H. Zhang, J. Zhao, Y. Ban, G. Chen, J. Li, Q. Li, S. Liu, Y. Mao, S. J. Qian, D. Wang, Z. Xu, Y. Wang, C. Avila, A. Cabrera, C. A. Carrillo Montoya, L. F. Chaparro Sierra, C. Florez, C. F. González Hernández, M. A. Segura Delgado, B. Courbon, N. Godinovic, D. Lelas, I. Puljak, P. M. Ribeiro Cipriano, T. Sculac, Z. Antunovic, M. Kovac, V. Brigljevic, D. Ferencek, K. Kadija, B. Mesic, A. Starodumov, T. Susa, M. W. Ather, A. Attikis, G. Mavromanolakis, J. Mousa, C. Nicolaou, F. Ptochos, P. A. Razis, H. Rykaczewski, M. Finger, E. Carrera Jarrin, S. Khalil, M. A. Mahmoud, Y. Mohammed, S. Bhowmik, R. K. Dewanjee, M. Kadastik, L. Perrini, M. Raidal, C. Veelken, P. Eerola, H. Kirschenmann, J. Pekkanen, M. Voutilainen, J. Havukainen, J. K. Heikkilä, T. Järvinen, V. Karimäki, R. Kinnunen, T. Lampén, K. Lassila-Perini, S. Laurila, S. Lehti, T. Lindén, P. Luukka, T. Mäenpää, H. Siikonen, E. Tuominen, J. Tuominiemi, T. Tuuva, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, J. L. Faure, F. Ferri, S. Ganjour, S. Ghosh, A. Givernaud, P. Gras, G. Hamel de Monchenault, P. Jarry, C. Leloup, E. Locci, M. Machet, J. Malcles, G. Negro, J. Rander, A. Rosowsky, M. Ö. Sahin, M. Titov, A. Abdulsalam, C. Amendola, I. Antropov, S. Baffioni, F. Beaudette, P. Busson, L. Cadamuro, C. Charlot, R. Granier de Cassagnac, M. Jo, I. Kucher, S. Lisniak, A. Lobanov, J. Martin Blanco, M. 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Cali, M. D’Alfonso, Z. Demiragli, G. Gomez Ceballos, M. Goncharov, P. Harris, D. Hsu, M. Hu, Y. Iiyama, G. M. Innocenti, M. Klute, D. Kovalskyi, Y.-J. Lee, A. Levin, P. D. Luckey, B. Maier, A.C. Marini, C. Mcginn, C. Mironov, S. Narayanan, X. Niu, C. Paus, C. Roland, G. Roland, G. S. F. Stephans, K. Sumorok, K. Tatar, D. Velicanu, T. W. Wang, B. Wyslouch, S. Zhaozhong, A. C. Benvenuti, R. M. Chatterjee, A. Evans, P. Hansen, S. Kalafut, Y. Kubota, Z. Lesko, J. Mans, S. Nourbakhsh, N. Ruckstuhl, R. Rusack, J. Turkewitz, M. A. Wadud, J. G. Acosta, S. Oliveros, E. Avdeeva, K. Bloom, D. R. Claes, C. Fangmeier, F. Golf, R. Gonzalez Suarez, R. Kamalieddin, I. Kravchenko, J. Monroy, J. E. Siado, G. R. Snow, B. Stieger, A. Godshalk, C. Harrington, I. Iashvili, D. Nguyen, A. Parker, S. Rappoccio, B. Roozbahani, G. Alverson, E. Barberis, C. Freer, A. Hortiangtham, A. Massironi, D.M. Morse, T. Orimoto, R. Teixeira De Lima, T. Wamorkar, B. Wang, A. Wisecarver, D. Wood, O. Charaf, K. A. Hahn, N. 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Lamichhane, T. Mengke, S. Muthumuni, T. Peltola, S. Undleeb, I. Volobouev, S. Greene, A. Gurrola, R. Janjam, W. Johns, C. Maguire, A. Melo, H. Ni, K. Padeken, J.D. Ruiz Alvarez, P. Sheldon, S. Tuo, J. Velkovska, Q. Xu, M. W. Arenton, P. Barria, B. Cox, R. Hirosky, M. Joyce, A. Ledovskoy, H. Li, C. Neu, T. Sinthuprasith, E. Wolfe, F. Xia, R. Harr, P. E. Karchin, N. Poudyal, J. Sturdy, P. Thapa, S. Zaleski, M. Brodski, J. Buchanan, C. Caillol, D. Carlsmith, S. Dasu, L. Dodd, S. Duric, B. Gomber, M. Grothe, M. Herndon, A. Hervé, U. Hussain, P. Klabbers, A. Lanaro, A. Levine, K. Long, R. Loveless, V. Rekovic, T. Ruggles, A. Savin, N. Smith, W. H. Smith, N. Woods, and CMS Collaboration
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Published: 2022
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29. Erratum to: Search for new physics in dijet angular distributions using proton-proton collisions at $$\sqrt{s} = 13\,\hbox {TeV}$$ s = 13 TeV and constraints on dark matter and other models

Author: A. M. Sirunyan, A. Tumasyan, W. Adam, F. Ambrogi, E. Asilar, T. Bergauer, J. Brandstetter, E. Brondolin, M. Dragicevic, J. Erö, A. Escalante Del Valle, M. Flechl, M. Friedl, R. Frühwirth, V. M. Ghete, J. Grossmann, J. Hrubec, M. Jeitler, A. König, N. Krammer, I. Krätschmer, D. Liko, T. Madlener, I. Mikulec, E. Pree, N. Rad, H. Rohringer, J. Schieck, R. Schöfbeck, M. Spanring, D. Spitzbart, A. Taurok, W. Waltenberger, J. Wittmann, C.-E. Wulz, M. Zarucki, V. Chekhovsky, V. Mossolov, J. Suarez Gonzalez, E. A. De Wolf, D. Di Croce, X. Janssen, J. Lauwers, M. Pieters, M. Van De Klundert, H. Van Haevermaet, P. Van Mechelen, N. Van Remortel, S. Abu Zeid, F. Blekman, J. D’Hondt, I. De Bruyn, J. De Clercq, K. Deroover, G. Flouris, D. Lontkovskyi, S. Lowette, I. Marchesini, S. Moortgat, L. Moreels, Q. Python, K. Skovpen, S. Tavernier, W. Van Doninck, P. Van Mulders, I. Van Parijs, D. Beghin, B. Bilin, H. Brun, B. Clerbaux, G. De Lentdecker, H. Delannoy, B. Dorney, G. Fasanella, L. Favart, R. Goldouzian, A. Grebenyuk, A. K. Kalsi, T. Lenzi, J. Luetic, T. Seva, E. Starling, C. Vander Velde, P. Vanlaer, D. Vannerom, R. Yonamine, T. Cornelis, D. Dobur, A. Fagot, M. Gul, I. Khvastunov, D. Poyraz, C. Roskas, D. Trocino, M. Tytgat, W. Verbeke, B. Vermassen, M. Vit, N. Zaganidis, H. Bakhshiansohi, O. Bondu, S. Brochet, G. Bruno, C. Caputo, A. Caudron, P. David, S. De Visscher, C. Delaere, M. Delcourt, B. Francois, A. Giammanco, G. Krintiras, V. Lemaitre, A. Magitteri, A. Mertens, M. Musich, K. Piotrzkowski, L. Quertenmont, A. Saggio, M. Vidal Marono, S. Wertz, J. Zobec, W. L. Aldá Júnior, F. L. Alves, G. A. Alves, L. Brito, G. Correia Silva, C. Hensel, A. Moraes, M. E. Pol, P. Rebello Teles, E. Belchior Batista Das Chagas, W. Carvalho, J. Chinellato, E. Coelho, E. M. Da Costa, G. G. Da Silveira, D. De Jesus Damiao, S. Fonseca De Souza, H. Malbouisson, M. Medina Jaime, M. Melo De Almeida, C. Mora Herrera, L. Mundim, H. Nogima, L. J. Sanchez Rosas, A. Santoro, A. Sznajder, M. Thiel, E. J. Tonelli Manganote, F. Torres Da Silva De Araujo, A. Vilela Pereira, S. Ahuja, C. A. Bernardes, L. Calligaris, T. R. Fernandez Perez Tomei, E. M. Gregores, P. G. Mercadante, S. F. Novaes, Sandra S. Padula, D. Romero Abad, J. C. Ruiz Vargas, A. Aleksandrov, R. Hadjiiska, P. Iaydjiev, A. Marinov, M. Misheva, M. Rodozov, M. Shopova, G. Sultanov, A. Dimitrov, L. Litov, B. Pavlov, P. Petkov, W. Fang, X. Gao, L. Yuan, M. Ahmad, J. G. Bian, G. M. Chen, H. S. Chen, M. Chen, Y. Chen, C. H. Jiang, D. Leggat, H. Liao, Z. Liu, F. Romeo, S. M. Shaheen, A. Spiezia, J. Tao, C. Wang, Z. Wang, E. Yazgan, H. Zhang, J. Zhao, Y. Ban, G. Chen, J. Li, Q. Li, S. Liu, Y. Mao, S. J. Qian, D. Wang, Z. Xu, Y. Wang, C. Avila, A. Cabrera, C. A. Carrillo Montoya, L. F. Chaparro Sierra, C. Florez, C. F. González Hernández, M. A. Segura Delgado, B. Courbon, N. Godinovic, D. Lelas, I. Puljak, P. M. Ribeiro Cipriano, T. Sculac, Z. Antunovic, M. Kovac, V. Brigljevic, D. Ferencek, K. Kadija, B. 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Abercrombie, B. Allen, V. Azzolini, R. Barbieri, A. Baty, G. Bauer, R. Bi, S. Brandt, W. Busza, I. A. Cali, M. D’Alfonso, Z. Demiragli, G. Gomez Ceballos, M. Goncharov, P. Harris, D. Hsu, M. Hu, Y. Iiyama, G. M. Innocenti, M. Klute, D. Kovalskyi, Y.-J. Lee, A. Levin, P. D. Luckey, B. Maier, A. C. Marini, C. Mcginn, C. Mironov, S. Narayanan, X. Niu, C. Paus, C. Roland, G. Roland, G. S. F. Stephans, K. Sumorok, K. Tatar, D. Velicanu, T. W. Wang, B. Wyslouch, S. Zhaozhong, A. C. Benvenuti, R. M. Chatterjee, A. Evans, P. Hansen, S. Kalafut, Y. Kubota, Z. Lesko, J. Mans, S. Nourbakhsh, N. Ruckstuhl, R. Rusack, J. Turkewitz, M. A. Wadud, J. G. Acosta, S. Oliveros, E. Avdeeva, K. Bloom, D. R. Claes, C. Fangmeier, F. Golf, R. Gonzalez Suarez, R. Kamalieddin, I. Kravchenko, J. Monroy, J. E. Siado, G. R. Snow, B. Stieger, A. Godshalk, C. Harrington, I. Iashvili, D. Nguyen, A. Parker, S. Rappoccio, B. Roozbahani, G. Alverson, E. Barberis, C. Freer, A. Hortiangtham, A. Massironi, D. M. Morse, T. 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Safonov, A. Tatarinov, N. Akchurin, J. Damgov, F. De Guio, P. R. Dudero, J. Faulkner, E. Gurpinar, S. Kunori, K. Lamichhane, T. Mengke, S. Muthumuni, T. Peltola, S. Undleeb, I. Volobouev, S. Greene, A. Gurrola, R. Janjam, W. Johns, C. Maguire, A. Melo, H. Ni, K. Padeken, J. D. Ruiz Alvarez, P. Sheldon, S. Tuo, J. Velkovska, Q. Xu, M. W. Arenton, P. Barria, B. Cox, R. Hirosky, M. Joyce, A. Ledovskoy, H. Li, C. Neu, T. Sinthuprasith, E. Wolfe, F. Xia, R. Harr, P. E. Karchin, N. Poudyal, J. Sturdy, P. Thapa, S. Zaleski, M. Brodski, J. Buchanan, C. Caillol, D. Carlsmith, S. Dasu, L. Dodd, S. Duric, B. Gomber, M. Grothe, M. Herndon, A. Hervé, U. Hussain, P. Klabbers, A. Lanaro, A. Levine, K. Long, R. Loveless, V. Rekovic, T. Ruggles, A. Savin, N. Smith, W. H. Smith, N. Woods, and CMS Collaboration
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Published: 2022
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30. Erratum to: Measurement of the top quark mass with lepton+jets final states using pp collisions at $$\sqrt{s} = 13\,\hbox {TeV}$$ s = 13 TeV

Author: A. M. Sirunyan, A. Tumasyan, W. Adam, F. Ambrogi, E. Asilar, T. Bergauer, J. Brandstetter, E. Brondolin, M. Dragicevic, J. Erö, A. Escalante Del Valle, M. Flechl, M. Friedl, R. Frühwirth, V. M. Ghete, J. Hrubec, M. Jeitler, N. Krammer, I. Krätschmer, D. Liko, T. Madlener, I. Mikulec, N. Rad, H. Rohringer, J. Schieck, R. Schöfbeck, M. Spanring, D. Spitzbart, A. Taurok, W. Waltenberger, J. Wittmann, C.-E. Wulz, M. Zarucki, V. Chekhovsky, V. Mossolov, J. Suarez Gonzalez, E. A. De Wolf, D. Di Croce, X. Janssen, J. Lauwers, M. Pieters, M. Van De Klundert, H. Van Haevermaet, P. Van Mechelen, N. Van Remortel, S. Abu Zeid, F. Blekman, J. D’Hondt, I. De Bruyn, J. De Clercq, K. Deroover, G. Flouris, D. Lontkovskyi, S. Lowette, I. Marchesini, S. Moortgat, L. Moreels, Q. Python, K. Skovpen, S. Tavernier, W. Van Doninck, P. Van Mulders, I. Van Parijs, D. Beghin, B. Bilin, H. Brun, B. Clerbaux, G. De Lentdecker, H. Delannoy, B. Dorney, G. Fasanella, L. Favart, R. Goldouzian, A. Grebenyuk, A. K. Kalsi, T. Lenzi, J. Luetic, T. Seva, E. Starling, C. Vander Velde, P. Vanlaer, D. Vannerom, R. Yonamine, T. Cornelis, D. Dobur, A. Fagot, M. Gul, I. Khvastunov, D. Poyraz, C. Roskas, D. Trocino, M. Tytgat, W. Verbeke, B. Vermassen, M. Vit, N. Zaganidis, H. Bakhshiansohi, O. Bondu, S. Brochet, G. Bruno, C. Caputo, A. Caudron, P. David, S. De Visscher, C. Delaere, M. Delcourt, B. Francois, A. Giammanco, G. Krintiras, V. Lemaitre, A. Magitteri, A. Mertens, M. Musich, K. Piotrzkowski, L. Quertenmont, A. Saggio, M. Vidal Marono, S. Wertz, J. Zobec, W. L. Aldá Júnior, F. L. Alves, G. A. Alves, L. Brito, G. Correia Silva, C. Hensel, A. Moraes, M. E. Pol, P. Rebello Teles, E. Belchior Batista Das Chagas, W. Carvalho, J. Chinellato, E. Coelho, E. M. Da Costa, G. G. Da Silveira, D. De Jesus Damiao, S. Fonseca De Souza, H. Malbouisson, M. Medina Jaime, M. Melo De Almeida, C. Mora Herrera, L. Mundim, H. Nogima, L. J. Sanchez Rosas, A. Santoro, A. Sznajder, M. Thiel, E. J. Tonelli Manganote, F. Torres Da Silva De Araujo, A. Vilela Pereira, S. Ahuja, C. A. Bernardes, Luigi Calligaris, T. R. Fernandez Perez Tomei, E. M. Gregores, P. G. Mercadante, S. F. Novaes, Sandra S. Padula, D. Romero Abad, J. C. Ruiz Vargas, A. Aleksandrov, R. Hadjiiska, P. Iaydjiev, A. Marinov, M. Misheva, M. Rodozov, M. Shopova, G. Sultanov, A. Dimitrov, L. Litov, B. Pavlov, P. Petkov, W. Fang, X. Gao, L. Yuan, M. Ahmad, J. G. Bian, G. M. Chen, H. S. Chen, M. Chen, Y. Chen, C. H. Jiang, D. Leggat, H. Liao, Z. Liu, F. Romeo, S. M. Shaheen, A. Spiezia, J. Tao, C. Wang, Z. Wang, E. Yazgan, H. Zhang, J. Zhao, Y. Ban, G. Chen, J. Li, Q. Li, S. Liu, Y. Mao, S. J. Qian, D. Wang, Z. Xu, Y. Wang, C. Avila, A. Cabrera, C. A. Carrillo Montoya, L. F. Chaparro Sierra, C. Florez, C. F. González Hernández, M. A. Segura Delgado, B. Courbon, N. Godinovic, D. Lelas, I. Puljak, T. Sculac, Z. Antunovic, M. Kovac, V. Brigljevic, D. Ferencek, K. Kadija, B. Mesic, A. Starodumov, T. Susa, M. W. Ather, A. Attikis, G. Mavromanolakis, J. Mousa, C. Nicolaou, F. Ptochos, P. A. Razis, H. Rykaczewski, M. Finger, E. Carrera Jarrin, M. A. Mahmoud, Elgammal A. Mohamed, E. Salama, S. Bhowmik, R. K. Dewanjee, M. Kadastik, L. Perrini, M. Raidal, C. Veelken, P. Eerola, H. Kirschenmann, J. Pekkanen, M. Voutilainen, J. Havukainen, J. K. Heikkilä, T. Järvinen, V. Karimäki, R. Kinnunen, T. Lampén, K. Lassila-Perini, S. Laurila, S. Lehti, T. Lindén, P. Luukka, T. Mäenpää, H. Siikonen, E. Tuominen, J. Tuominiemi, T. Tuuva, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, J. L. Faure, F. Ferri, S. Ganjour, S. Ghosh, A. Givernaud, P. Gras, G. Hamel de Monchenault, P. Jarry, C. Leloup, E. Locci, M. Machet, J. Malcles, G. Negro, J. Rander, A. Rosowsky, M.Ö. Sahin, M. Titov, A. Abdulsalam, C. Amendola, I. Antropov, S. Baffioni, F. Beaudette, P. Busson, L. Cadamuro, C. Charlot, R. Granier de Cassagnac, M. Jo, I. Kucher, S. Lisniak, A. Lobanov, J. Martin Blanco, M. Nguyen, C. Ochando, G. Ortona, P. 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Beck, J. J. Brooke, D. Burns, E. Clement, D. Cussans, O. Davignon, H. Flacher, J. Goldstein, G. P. Heath, H. F. Heath, L. Kreczko, D. M. Newbold, S. Paramesvaran, T. Sakuma, S. Seif El Nasr-storey, D. Smith, V. J. Smith, K. W. Bell, C. Brew, R. M. Brown, D. Cieri, D. J. A. Cockerill, J. A. Coughlan, K. Harder, S. Harper, J. Linacre, E. Olaiya, D. Petyt, C. H. Shepherd-Themistocleous, A. Thea, I. R. Tomalin, T. Williams, W. J. Womersley, G. Auzinger, R. Bainbridge, P. Bloch, J. Borg, S. Breeze, O. Buchmuller, A. Bundock, S. Casasso, D. Colling, L. Corpe, P. Dauncey, G. Davies, M. Della Negra, R. Di Maria, Y. Haddad, G. Hall, G. Iles, T. James, M. Komm, R. Lane, C. Laner, L. Lyons, A.-M. Magnan, S. Malik, L. Mastrolorenzo, T. Matsushita, J. Nash, A. Nikitenko, V. Palladino, M. Pesaresi, A. Richards, A. Rose, E. Scott, C. Seez, A. Shtipliyski, T. Strebler, S. Summers, A. Tapper, K. Uchida, M. Vazquez Acosta, T. Virdee, N. Wardle, D. Winterbottom, J. Wright, S. C. Zenz, J. E. Cole, P. R. Hobson, A. Khan, P. Kyberd, A. Morton, I. D. Reid, L. Teodorescu, S. Zahid, A. Borzou, K. Call, J. Dittmann, K. Hatakeyama, H. Liu, N. Pastika, C. Smith, R. Bartek, A. Dominguez, A. Buccilli, S. I. Cooper, C. Henderson, P. Rumerio, C. West, D. Arcaro, A. Avetisyan, T. Bose, D. Gastler, D. Rankin, C. Richardson, J. Rohlf, L. Sulak, D. Zou, G. Benelli, D. Cutts, M. Hadley, J. Hakala, U. Heintz, J. M. Hogan, K. H. M. Kwok, E. Laird, G. Landsberg, Z. Mao, M. Narain, J. Pazzini, S. Piperov, S. Sagir, R. Syarif, D. Yu, R. Band, C. Brainerd, R. Breedon, M. Calderon De La Barca Sanchez, M. Chertok, J. Conway, R. Conway, P. T. Cox, R. Erbacher, C. Flores, G. Funk, W. Ko, R. Lander, C. Mclean, M. Mulhearn, D. Pellett, J. Pilot, S. Shalhout, M. Shi, J. Smith, D. Stolp, D. Taylor, K. Tos, M. Tripathi, F. Zhang, M. Bachtis, C. Bravo, R. Cousins, A. Dasgupta, A. Florent, J. Hauser, M. Ignatenko, N. Mccoll, S. Regnard, D. Saltzberg, C. Schnaible, V. Valuev, E. Bouvier, K. Burt, R. Clare, J. Ellison, J. W. Gary, S. M. A. Ghiasi Shirazi, G. Hanson, G. Karapostoli, E. Kennedy, F. Lacroix, O. R. Long, M. Olmedo Negrete, M. I. Paneva, W. Si, L. Wang, H. Wei, S. Wimpenny, B. R. Yates, J. G. Branson, S. Cittolin, M. Derdzinski, R. Gerosa, D. Gilbert, B. Hashemi, A. Holzner, D. Klein, G. Kole, V. Krutelyov, J. Letts, M. Masciovecchio, D. Olivito, S. Padhi, M. Pieri, M. Sani, V. Sharma, S. Simon, M. Tadel, A. Vartak, S. Wasserbaech, J. Wood, F. Würthwein, A. Yagil, G. Zevi Della Porta, N. Amin, R. Bhandari, J. Bradmiller-Feld, C. Campagnari, M. Citron, A. Dishaw, V. Dutta, M. Franco Sevilla, L. Gouskos, R. Heller, J. Incandela, A. Ovcharova, H. Qu, J. Richman, D. Stuart, I. Suarez, J. Yoo, D. Anderson, A. Bornheim, J. Bunn, J. M. Lawhorn, H. B. Newman, T. Q. Nguyen, C. Pena, M. Spiropulu, J. R. Vlimant, R. Wilkinson, S. Xie, Z. Zhang, R. Y. Zhu, M. B. Andrews, T. Ferguson, T. Mudholkar, M. Paulini, J. Russ, M. Sun, H. Vogel, I. Vorobiev, M. Weinberg, J. P. Cumalat, W. T. Ford, F. Jensen, A. Johnson, M. Krohn, S. Leontsinis, E. MacDonald, T. Mulholland, K. Stenson, K. A. Ulmer, S. R. Wagner, J. Alexander, J. Chaves, Y. Cheng, J. Chu, A. Datta, K. Mcdermott, N. Mirman, J. R. Patterson, D. Quach, A. Rinkevicius, A. Ryd, L. Skinnari, L. Soffi, S. M. Tan, Z. Tao, J. Thom, J. Tucker, P. Wittich, M. Zientek, S. Abdullin, M. Albrow, M. Alyari, G. Apollinari, A. Apresyan, A. Apyan, L. A. T. Bauerdick, A. Beretvas, J. Berryhill, P. C. Bhat, G. Bolla, K. Burkett, J. N. Butler, A. Canepa, G. B. Cerati, H. W. K. Cheung, F. Chlebana, M. Cremonesi, J. Duarte, V. D. Elvira, J. Freeman, Z. Gecse, E. Gottschalk, L. Gray, D. Green, S. Grünendahl, O. Gutsche, J. Hanlon, R. M. Harris, S. Hasegawa, J. Hirschauer, Z. Hu, B. Jayatilaka, S. Jindariani, M. Johnson, U. Joshi, B. Klima, M. J. Kortelainen, B. Kreis, S. Lammel, D. Lincoln, R. Lipton, M. Liu, T. Liu, R. Lopes De Sá, J. Lykken, K. Maeshima, N. Magini, J. M. Marraffino, D. Mason, P. McBride, P. Merkel, S. Mrenna, S. Nahn, V. O’Dell, K. Pedro, O. Prokofyev, G. Rakness, L. Ristori, A. Savoy-Navarro, B. Schneider, E. Sexton-Kennedy, A. Soha, W. J. Spalding, L. Spiegel, S. Stoynev, J. Strait, N. Strobbe, L. Taylor, S. Tkaczyk, N. V. Tran, L. Uplegger, E. W. Vaandering, C. Vernieri, M. Verzocchi, R. Vidal, M. Wang, H. A. Weber, A. Whitbeck, W. Wu, D. Acosta, P. Avery, P. Bortignon, D. Bourilkov, A. Brinkerhoff, A. Carnes, M. Carver, D. Curry, R. D. Field, I. K. Furic, S. V. Gleyzer, B. M. Joshi, J. Konigsberg, A. Korytov, K. Kotov, P. Ma, K. Matchev, H. Mei, G. Mitselmakher, K. Shi, D. Sperka, N. Terentyev, L. Thomas, J. Wang, S. Wang, J. Yelton, Y. R. Joshi, S. Linn, P. Markowitz, J. L. Rodriguez, A. Ackert, T. Adams, A. Askew, S. Hagopian, V. Hagopian, K. F. Johnson, T. Kolberg, G. Martinez, T. Perry, H. Prosper, A. Saha, A. Santra, R. Yohay, M. M. Baarmand, V. Bhopatkar, S. Colafranceschi, M. Hohlmann, D. Noonan, T. Roy, F. Yumiceva, M. R. Adams, L. Apanasevich, D. Berry, R. R. Betts, R. Cavanaugh, X. Chen, S. Dittmer, O. Evdokimov, C. E. Gerber, D. A. Hangal, D. J. Hofman, K. Jung, J. Kamin, I. D. Sandoval Gonzalez, M. B. Tonjes, N. Varelas, H. Wang, Z. Wu, J. Zhang, B. Bilki, W. Clarida, K. Dilsiz, S. Durgut, R. P. Gandrajula, M. Haytmyradov, V. Khristenko, J.-P. Merlo, H. Mermerkaya, A. Mestvirishvili, A. Moeller, J. Nachtman, H. Ogul, Y. Onel, F. Ozok, A. Penzo, C. Snyder, E. Tiras, J. Wetzel, K. Yi, B. Blumenfeld, A. Cocoros, N. Eminizer, D. Fehling, L. Feng, A. V. Gritsan, W. T. Hung, P. Maksimovic, J. Roskes, U. Sarica, M. Swartz, M. Xiao, C. You, A. Al-bataineh, P. Baringer, A. Bean, J. F. Benitez, S. Boren, J. Bowen, J. Castle, S. Khalil, A. Kropivnitskaya, D. Majumder, W. Mcbrayer, M. Murray, C. Rogan, C. Royon, S. Sanders, E. Schmitz, J. D. Tapia Takaki, Q. Wang, A. Ivanov, K. Kaadze, Y. Maravin, A. Modak, A. Mohammadi, L. K. Saini, N. Skhirtladze, F. Rebassoo, D. Wright, A. Baden, O. Baron, A. Belloni, S. C. Eno, Y. Feng, C. Ferraioli, N. J. Hadley, S. Jabeen, G. Y. Jeng, R. G. Kellogg, J. Kunkle, A. C. Mignerey, F. Ricci-Tam, Y. H. Shin, A. Skuja, S. C. Tonwar, D. Abercrombie, B. Allen, V. Azzolini, R. Barbieri, A. Baty, G. Bauer, R. Bi, S. Brandt, W. Busza, I. A. Cali, M. D’Alfonso, Z. Demiragli, G. Gomez Ceballos, M. Goncharov, P. Harris, D. Hsu, M. Hu, Y. Iiyama, G. M. Innocenti, M. Klute, D. Kovalskyi, Y.-J. Lee, A. Levin, P. D. Luckey, B. Maier, A. C. Marini, C. Mcginn, C. Mironov, S. Narayanan, X. Niu, C. Paus, C. Roland, G. Roland, G. S. F. Stephans, K. Sumorok, K. Tatar, D. Velicanu, T. W. Wang, B. Wyslouch, S. Zhaozhong, A. C. Benvenuti, R. M. Chatterjee, A. Evans, P. Hansen, S. Kalafut, Y. Kubota, Z. Lesko, J. Mans, S. Nourbakhsh, N. Ruckstuhl, R. Rusack, J. Turkewitz, M. A. Wadud, J. G. Acosta, S. Oliveros, E. Avdeeva, K. Bloom, D. R. Claes, C. Fangmeier, F. Golf, R. Gonzalez Suarez, R. Kamalieddin, I. Kravchenko, J. Monroy, J. E. Siado, G. R. Snow, B. Stieger, A. Godshalk, C. Harrington, I. Iashvili, D. Nguyen, A. Parker, S. Rappoccio, B. Roozbahani, G. Alverson, E. Barberis, C. Freer, A. Hortiangtham, A. Massironi, D. M. Morse, T. Orimoto, R. Teixeira De Lima, T. Wamorkar, B. Wang, A. Wisecarver, D. Wood, O. Charaf, K. A. Hahn, N. Mucia, N. Odell, M. H. Schmitt, K. Sung, M. Trovato, M. Velasco, R. Bucci, N. Dev, M. Hildreth, K. Hurtado Anampa, C. Jessop, D. J. Karmgard, N. Kellams, K. Lannon, W. Li, N. Loukas, N. Marinelli, F. Meng, C. Mueller, Y. Musienko, M. Planer, A. Reinsvold, R. Ruchti, P. Siddireddy, G. Smith, S. Taroni, M. Wayne, A. Wightman, M. Wolf, A. Woodard, J. Alimena, L. Antonelli, B. Bylsma, L. S. Durkin, S. Flowers, B. Francis, A. Hart, C. Hill, W. Ji, T. Y. Ling, W. Luo, B. L. Winer, H. W. Wulsin, S. Cooperstein, O. Driga, P. Elmer, J. Hardenbrook, P. Hebda, S. Higginbotham, A. Kalogeropoulos, D. Lange, J. Luo, D. Marlow, K. Mei, I. Ojalvo, J. Olsen, C. Palmer, P. Piroué, J. Salfeld-Nebgen, D. Stickland, C. Tully, S. Norberg, A. Barker, V. E. Barnes, S. Das, L. Gutay, M. Jones, A. W. Jung, A. Khatiwada, D. H. Miller, N. Neumeister, C. C. Peng, H. Qiu, J. F. Schulte, J. Sun, F. Wang, R. Xiao, W. Xie, T. Cheng, J. Dolen, N. Parashar, Z. Chen, K. M. Ecklund, S. Freed, F. J. M. Geurts, M. Guilbaud, M. Kilpatrick, B. Michlin, B. P. Padley, J. Roberts, J. Rorie, W. Shi, Z. Tu, J. Zabel, A. Zhang, A. Bodek, P. de Barbaro, R. Demina, Y. t. Duh, T. Ferbel, M. Galanti, A. Garcia-Bellido, J. Han, O. Hindrichs, A. Khukhunaishvili, K. H. Lo, P. Tan, M. Verzetti, R. Ciesielski, K. Goulianos, C. Mesropian, A. Agapitos, J. P. Chou, Y. Gershtein, T. A. Gómez Espinosa, E. Halkiadakis, M. Heindl, E. Hughes, S. Kaplan, R. Kunnawalkam Elayavalli, S. Kyriacou, A. Lath, R. Montalvo, K. Nash, M. Osherson, H. Saka, S. Salur, S. Schnetzer, D. Sheffield, S. Somalwar, R. Stone, S. Thomas, P. Thomassen, M. Walker, A. G. Delannoy, J. Heideman, G. Riley, K. Rose, S. Spanier, K. Thapa, O. Bouhali, A. Castaneda Hernandez, A. Celik, M. Dalchenko, M. De Mattia, A. Delgado, S. Dildick, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, R. Mueller, Y. Pakhotin, R. Patel, A. Perloff, L. Perniè, D. Rathjens, A. Safonov, A. Tatarinov, N. Akchurin, J. Damgov, F. De Guio, P. R. Dudero, J. Faulkner, E. Gurpinar, S. Kunori, K. Lamichhane, T. Mengke, S. Muthumuni, T. Peltola, S. Undleeb, I. Volobouev, S. Greene, A. Gurrola, R. Janjam, W. Johns, C. Maguire, A. Melo, H. Ni, K. Padeken, J. D. Ruiz Alvarez, P. Sheldon, S. Tuo, J. Velkovska, Q. Xu, M. W. Arenton, P. Barria, B. Cox, R. Hirosky, M. Joyce, A. Ledovskoy, H. Li, C. Neu, T. Sinthuprasith, E. Wolfe, F. Xia, R. Harr, P. E. Karchin, N. Poudyal, J. Sturdy, P. Thapa, S. Zaleski, M. Brodski, J. Buchanan, C. Caillol, D. Carlsmith, S. Dasu, L. Dodd, S. Duric, B. Gomber, M. Grothe, M. Herndon, A. Hervé, U. Hussain, P. Klabbers, A. Lanaro, A. Levine, K. Long, R. Loveless, V. Rekovic, T. Ruggles, A. Savin, N. Smith, W. H. Smith, N. Woods, and CMS Collaboration
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Published: 2022
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31. The assessment of a novel lower body resistance garment as a mechanism to increase the training stimulus during running: a randomised cross-over study

Author: Samantha M. Hoffmann, Isaiah Di Domenico, and Paul K. Collins
Subjects: Wearable resistance, Limb loading, Exercise physiology, Sports medicine, RC1200-1245
Abstract: Abstract Background This study examined the physiological and perceived impact of wearing a novel lower body resistance garment during exercise and recovery. Methods Using a randomised cross-over design, 15 recreationally-active males performed 2 × 10-min steady-state runs followed by a 10-min passive recovery with concomitant monitoring of oxygen consumption (V̇O2), heart rate (HR) and rating of perceived exertion (RPE; exercise portion only), wearing either the resistance garment (experimental) or running shorts (control). Results During exercise, there was a trend for V̇O2 and RPE to be higher (4.5% and 7.7% respectively) in experimental than control (V̇O2: r = 0.24, p > 0.05; RPE: r = 0.32, p > 0.05) and for HR to be lower (− 0.4%, r = − 0.05, p > 0.05). During recovery, V̇O2 and HR tended to be lower (4.7% and 4.3% respectively) in experimental than control (V̇O2: r = − 0.32, p > 0.05; HR: r = − 0.27, p > 0.05). Conclusions Though effects were trivial to small, and not statistically significant, these findings provide proof of concept and suggest that this garment design may increase the training stimulus during running and aid post-exercise recovery.
Published: 2022
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32. EFFECTS OF HOMOLOGOUS AND HETEROLOGOUS BOOSTER VACCINATIONS OF THE INACTIVATED DUAL-ADJUVANTED VACCINE VLA2001 AGAINST COVID-19 INCLUDING VARIANTS OF CONCERN: A PHASE 3 RANDOMIZED CLINICAL TRIAL

Author: N. Wressnigg, C. Taucher, S. Eder-Lingelbach, B. Querton, M. Krammer, A. Lilja, R. Hochreiter, M. Hoffmann, S. Pöhlmann, and J.-C. Jaramillo
Subjects: Infectious and parasitic diseases, RC109-216
Abstract: Intro: VLA2001 is a highly-purified, inactivated whole-virus SARS-CoV-2 vaccine based on a dual-adjuvant system of Alum and CpG1018 for induction of a robust immune response. The vaccine was designed using a well-established technology platform and has received full marketing authorization in Europe. In a pivotal Phase 3 trial, VLA2001 demonstrated superior neutralizing antibody geometric mean titers (GMT) to the comparator, AstraZeneca's AZD1222, as well as non-inferior seroconversion rates two weeks after priming. The extension of the Phase 3 trial evaluated safety and immunogenicity of homologous and heterologous booster vaccinations of VLA2001. Methods: This is a randomized observer-blind controlled, pivotal trial conducted in the UK in participants aged ≥18 years who were randomly assigned 2:1 to receive two doses of VLA2001 or AZD1222, 28 days apart. A booster with VLA2001 was administered to eligible participants at 7 to 8 months after priming. The primary safety outcome was the frequency and severity of any adverse event following the booster vaccination. The primary immunogenicity outcomes were the GMT and fold increase of neutralizing antibodies against SARS-CoV-2 two weeks after the booster vaccination. The study is registered under NCT04864561. Findings: A booster dose of VLA2001 is well-tolerated in both AZD1222 and VLA2001 primed participants. High neutralizing antibody titers and fold- increases were generated two weeks following a booster of VLA2001. Cross- neutralizing serological responses against Delta and the Omicron BA.4/BA.5 variants of concern are elicited following a homologous or heterologous booster dose in VLA2001 or AZD1222 primed participants, respectively. Additionally, VLA2001 induced broad T-cell responses with antigen-specific IFN-gamma producing T-cells against the Spike, the Nucleocapsid and the Membrane protein. Conclusion: Homologous and heterologous booster doses of VLA2001 demonstrated a favorable tolerability profile irrespective of priming and induced broadly reactive neutralizing antibodies against the ancestral virus and variants of concern, including the currently circulating BA.4/BA.5.
Published: 2023
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33. Double J/ψ production in pion-nucleon scattering at COMPASS

Author: G.D. Alexeev, M.G. Alexeev, A. Amoroso, V. Andrieux, V. Anosov, K. Augsten, W. Augustyniak, C.D.R. Azevedo, B. Badełek, M. Ball, J. Barth, R. Beck, Y. Bedfer, J. Bernhard, M. Bodlak, F. Bradamante, A. Bressan, V.E. Burtsev, W.-C. Chang, C. Chatterjee, M. Chiosso, A.G. Chumakov, S.-U. Chung, A. Cicuttin, P.M.M. Correia, M.L. Crespo, D. D'Ago, S. Dalla Torre, S.S. Dasgupta, S. Dasgupta, I. Denisenko, O.Yu. Denisov, S.V. Donskov, N. Doshita, Ch. Dreisbach, W. Dünnweber, R.R. Dusaev, D. Ecker, A. Efremov, D. Eremeev, P.D. Eversheim, P. Faccioli, M. Faessler, M. Finger, M. Finger, jr., H. Fischer, K.J. Flöthner, W. Florian, C. Franco, J.M. Friedrich, V. Frolov, L.G. Garcia Ordòñez, F. Gautheron, O.P. Gavrichtchouk, S. Gerassimov, J. Giarra, D. Giordano, M. Gorzellik, A. Grasso, A. Gridin, S. Groote, M. Grosse Perdekamp, B. Grube, M. Grüner, A. Guskov, D. von Harrach, M. Hoffmann, N. Horikawa, N. d'Hose, C.-Y. Hsieh, S. Huber, S. Ishimoto, A. Ivanov, T. Iwata, M. Jandek, V. Jary, R. Joosten, E. Kabuß, F. Kaspar, A. Kerbizi, B. Ketzer, A. Khatun, G.V. Khaustov, Yu.A. Khokhlov, F. Klein, J.H. Koivuniemi, V.N. Kolosov, K. Kondo Horikawa, I. Konorov, V.F. Konstantinov, A.M. Korzenev, S. Koshkarev, A.M. Kotzinian, O.M. Kouznetsov, A. Koval, Z. Kral, F. Krinner, F. Kunne, K. Kurek, R.P. Kurjata, A. Kveton, K. Lavickova, S. Levorato, Y.-S. Lian, J. Lichtenstadt, P.-J. Lin, R. Longo, V.E. Lyubovitskij, A. Maggiora, A. Magnon, N. Makins, N. Makke, G.K. Mallot, A. Maltsev, S.A. Mamon, A. Martin, J. Marzec, J. Matoušek, T. Matsuda, G. Mattson, C. Menezes Pires, F. Metzger, M. Meyer, W. Meyer, Yu.V. Mikhailov, M. Mikhasenko, E. Mitrofanov, Y. Miyachi, R. Molina, A. Moretti, A. Nagaytsev, C. Naim, D. Neyret, J. Nový, W.-D. Nowak, G. Nukazuka, A.G. Olshevsky, M. Ostrick, D. Panzieri, B. Parsamyan, S. Paul, H. Pekeler, J.-C. Peng, M. Pešek, D.V. Peshekhonov, M. Pešková, S. Platchkov, J. Pochodzalla, V.A. Polyakov, J. Pretz, M. Quaresma, C. Quintans, G. Reicherz, C. Riedl, T. Rudnicki, D.I. Ryabchikov, A. Rychter, A. Rymbekova, V.D. Samoylenko, A. Sandacz, S. Sarkar, I.A. Savin, G. Sbrizzai, H. Schmieden, A. Selyunin, K. Sharko, L. Sinha, M. Slunecka, D. Spülbeck, A. Srnka, M. Stolarski, O. Subrt, M. Sulc, H. Suzuki, S. Tessaro, F. Tessarotto, A. Thiel, J. Tomsa, F. Tosello, A. Townsend, T. Triloki, V. Tskhay, B. Valinoti, B.M. Veit, J.F.C.A. Veloso, B. Ventura, M. Virius, M. Wagner, S. Wallner, K. Zaremba, M. Zavertyaev, M. Zemko, E. Zemlyanichkina, and M. Ziembicki
Subjects: COMPASS, Charmonia production, Double J/ψ, Single parton scattering, Intrinsic charm, Physics, QC1-999
Abstract: We present the study of the production of double J/ψ mesons using COMPASS data collected with a 190 GeV/c π− beam scattering off NH3, Al and W targets. Kinematic distributions of the collected double J/ψ events are analysed, and the double J/ψ production cross section is estimated for each of the COMPASS targets. The NH3 results are compared to predictions from single- and double-parton scattering models as well as the pion intrinsic charm and the tetraquark exotic resonance hypotheses. It is demonstrated that the single parton scattering production mechanism gives the dominant contribution that is sufficient to describe the data. An upper limit on the double intrinsic charm content of the pion is evaluated. No significant signatures that could be associated with exotic tetraquarks are found in the double J/ψ mass spectrum.
Published: 2023
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34. Childhood glaucoma registry in Germany: initial database, clinical care and research (pilot study)

Author: Fidan A. Aghayeva, Alexander K. Schuster, Heidi Diel, Panagiotis Chronopoulos, Felix M. Wagner, Franz Grehn, Nina Pirlich, Susann Schweiger, Norbert Pfeiffer, and Esther M. Hoffmann
Subjects: Childhood glaucoma registry, Congenital glaucoma, Consanguinity, Genetic examination, Questionnaire, Medicine, Biology (General), QH301-705.5, Science (General), Q1-390
Abstract: Abstract Objective The aim of this prospective pilot study is to establish an initial database to register patients diagnosed with different types of childhood glaucoma and the set-up of a national registry for childhood glaucoma (ReCG) in Germany. 28 children with different types of diagnosed childhood glaucoma, who were admitted and treated at the Childhood Glaucoma Center of the University Medical Center Mainz, Germany were included. Main outcome measures were the type of childhood glaucoma, mean intraocular pressure (IOP) and genetic data of the patients. Results The documents and questionnaires for each individual included: informed consent form of the parents, medical history form of the child, patient’s gestational history questionnaire and general anesthesia examination form. Primary congenital and secondary childhood glaucoma were revealed in 11 (39%) and 17 (61%) patients, respectively. The mean IOP measured with Perkins tonometer in all patients under general anesthesia at the time of inclusion was 17.5 ± 11.8 mmHg in the right and 17 ± 8.9 mmHg in the left eyes. In 33% of children with glaucoma mutations in the CYP1B1, FOXC1, LTBP2 and TEK genes were found. The development of specific questionnaires for childhood glaucoma provides detailed baseline data to establish a ReCG in Germany for the first time.
Published: 2022
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35. Brine residues and organics in the Urvara basin on Ceres

Author: A. Nathues, M. Hoffmann, N. Schmedemann, R. Sarkar, G. Thangjam, K. Mengel, J. Hernandez, H. Hiesinger, and J. H. Pasckert
Subjects: Science
Abstract: The authors report the discovery of salts and fresh organic-rich exposures in the Urvara basin, possibly linked to a late resurfacing of the crater floor. These results are consistent with a deep-seated brine/salt reservoir in the crust of Ceres.
Published: 2022
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36. Do biometric parameters improve the quality of optic nerve head measurements with spectral domain optical coherence tomography?

Author: E. Elksne, J. V. Stingl, A. K. Schuster, F. M. Wagner, and E. M. Hoffmann
Subjects: SD-OCT, Optic nerve head, RNFL, MRW, BMO, Ophthalmology, RE1-994
Abstract: Abstract Background Spectral domain optical coherence tomography (SD-OCT) is a widely applied non-invasive technique for evaluating optic nerve head parameters. The aim of this study was to evaluate the impact of biometric parameters such as the spherical equivalent (SE) and the anterior corneal curvature (ACC) on the peripapillary retinal nerve fiber layer (pRNFL), Bruch’s membrane opening (BMO), and the minimum rim width (MRW) measurements performed by spectral domain optical coherence tomography (SD-OCT) in glaucomatous and healthy eyes. Methods In this cross-sectional, case–control prospective pilot study, the glaucoma group consisted of 50 patients with previously diagnosed and treated glaucoma and one healthy group of 50 subjects. Two consecutive examinations of pRNFL, BMO, and MRW with SD-OCT for every patient were performed without ACC and objective refraction (imaging 1) and with them (imaging 2). Results The interclass correlation coefficient (ICC) reflected high agreement between imaging 1 and imaging 2 in both groups. The ICC in the glaucoma and healthy groups for pRNFL (0.99 vs. 0.98), BMO (0.95 vs. 0.97), and MRW (1.0 vs. 1.0) was comparable. Conclusions Our preliminary data from a small number of eyes showed that the measurements of pRNFL, MRW, and BMO reflected high agreement between both imaging techniques with ACC and objective refraction and without these parameters in subjects with a refractive error up to ± 6.0 diopters. Further studies with participants with higher refractive error are necessary to evaluate the impact of biometric parameters such as SE and ACC on measurements with SD-OCT.
Published: 2022
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37. Continuous flow analysis methods for sodium, magnesium and calcium detection in the Skytrain ice core

Author: Mackenzie M. Grieman, Helene M. Hoffmann, Jack D. Humby, Robert Mulvaney, Christoph Nehrbass-Ahles, Julius Rix, Elizabeth R. Thomas, Rebecca Tuckwell, and Eric W. Wolff
Subjects: Glaciological instruments and methods, ice core, paleoclimate, Environmental sciences, GE1-350, Meteorology. Climatology, QC851-999
Abstract: Dissolved and particulate sodium, magnesium and calcium are analyzed in ice cores to determine past changes in sea ice extent, terrestrial dust variability and atmospheric aerosol transport efficiency. They are also used to date ice cores if annual layers are visible. Multiple methods have been developed to analyze these important compounds in ice cores. Continuous flow analysis (CFA) is implemented with instruments that sample the meltstream continuously. In this study, CFA with ICP-MS (inductively coupled-plasma mass spectrometry) and fast ion chromatography (FIC) methods are compared for analysis of sodium and magnesium. ICP-MS, FIC and fluorescence methods are compared for analysis of calcium. Respective analysis of a 10 m section of the Antarctic WACSWAIN Skytrain Ice Rise ice core shows that all of the methods result in similar levels of the compounds. The ICP-MS method is the most suitable for analysis of the Skytrain ice core due to its superior precision (relative standard deviation: 1.6% for Na, 1.3% for Mg and 1.2% for Ca) and sampling frequency compared to the FIC method. The fluorescence detection method may be preferred for calcium analysis due to its higher depth resolution (1.4 cm) relative to the ICP-MS and FIC methods (~4 cm).
Published: 2022
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38. Long-term success after trabeculectomy in open-angle glaucoma: results of a retrospective cohort study

Author: Norbert Pfeiffer, Alexander K Schuster, Julia Stingl, Esther M Hoffmann, Felix Mathias Wagner, and Keywan Kianusch
Subjects: Medicine
Abstract: Objective To evaluate the long-term outcomes of trabeculectomy (TE) surgery in a large cohort with a minimum follow-up of 3 years.Design Retrospective cohort study.Setting University Eye Hospital, Germany.Participants Three hundred and seventy-nine patients with open-angle glaucoma underwent TE with mitomycin C (MMC) between January 2013 and February 2017 with a minimal follow-up of 3 years. Eligible patients were identified via an electronic surgical case register.Interventions All patients had undergone TE with MMC following a set surgical protocol. To assess the influence of cataract surgery following TE, eyes which underwent cataract surgery at least 6 months after TE were matched 1:3 by sex and age to eyes who did not undergo cataract surgery during the follow-up period.Main outcome measures Primary outcome was the proportion of surgical success based on intraocular pressure (IOP), surgical complications, the need for revision surgery, loss of light perception and the need for additional pressure-lowering medication.Results The mean follow-up time was 6 (±0.8, IQR: 5.4–6.5) years. Seventy-three per cent of eyes achieved qualified surgical success at the last follow-up (IOP≥5 mm Hg and ≤18 mm Hg, without surgical complications or complete loss of vision) but necessitated additional medical therapy, complete surgical success with no additional medical therapy was achieved in 69% of eyes. There was no significant difference in the success probability between eyes that had undergone cataract surgery after TE and those that had not (p=0.45).Conclusions The results demonstrate a high and stable success rate of TE after a mean follow-up time of approximately 6 years, that is, not affected by later cataract surgery.
Published: 2023
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39. Placental circadian lincRNAs and spontaneous preterm birth

Author: Guoli Zhou, Raina N. Fichorova, Claudia Holzman, Bin Chen, Chi Chang, Eric P. Kasten, and Hanne M. Hoffmann
Subjects: preterm (birth), molecular clock, lincRNA, transcriptional co-alteration, GSVA analysis, Genetics, QH426-470
Abstract: Long non-coding RNAs (lncRNAs) have a much higher cell- and/or tissue-specificity compared to mRNAs in most cases, making them excellent candidates for therapeutic applications to reduce off-target effects. Placental long non-coding RNAs have been investigated in the pathogenesis of preeclampsia (often causing preterm birth (PTB)), but less is known about their role in preterm birth. Preterm birth occurs in 11% of pregnancies and is the most common cause of death among infants in the world. We recently identified that genes that drive circadian rhythms in cells, termed molecular clock genes, are deregulated in maternal blood of women with spontaneous PTB (sPTB) and in the placenta of women with preeclampsia. Next, we focused on circadian genes-correlated long intergenic non-coding RNAs (lincRNAs, making up most of the long non-coding RNAs), designated as circadian lincRNAs, associated with sPTB. We compared the co-altered circadian transcripts-correlated lincRNAs expressed in placentas of sPTB and term births using two published independent RNAseq datasets (GSE73712 and GSE174415). Nine core clock genes were up- or downregulated in sPTB versus term birth, where the RORA transcript was the only gene downregulated in sPTB across both independent datasets. We found that five circadian lincRNAs (LINC00893, LINC00265, LINC01089, LINC00482, and LINC00649) were decreased in sPTB vs term births across both datasets (p ≤ .0222, FDR≤.1973) and were negatively correlated with the dataset-specific clock genes-based risk scores (correlation coefficient r = −.65 ∼ -.43, p ≤ .0365, FDR≤.0601). Gene set variation analysis revealed that 65 pathways were significantly enriched by these same five differentially expressed lincRNAs, of which over 85% of the pathways could be linked to immune/inflammation/oxidative stress and cell cycle/apoptosis/autophagy/cellular senescence. These findings may improve our understanding of the pathogenesis of spontaneous preterm birth and provide novel insights into the development of potentially more effective and specific therapeutic targets against sPTB.
Published: 2023
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40. Influence of different primary surgical techniques on long-term intraocular pressure and medication in glaucoma after congenital cataract surgery.

Author: Alicja Strzalkowska, Piotr Strzalkowski, Julia V Stingl, Norbert Pfeiffer, Alexander K Schuster, and Esther M Hoffmann
Subjects: Medicine, Science
Abstract: PurposeTo assess long-time results of primary surgical treatment in children with glaucoma after congenital cataract surgery.MethodsA retrospective study of 37 eyes from 35 children with glaucoma after congenital cataract surgery, who underwent surgery between 2011 and 2021 at the Childhood Glaucoma Center, University Medical Center Mainz, Germany. Only children, who received a primary glaucoma surgery in our clinic within the given time (n = 25) and had at least one-year follow-up (n = 21), were included in the further analysis. The mean follow-up time was 40.4±35.1 months. The primary outcome was the mean reduction in IOP (in mmHg) from baseline to follow-up visits after the surgery, measured with Perkins tonometry.Results8 patients (38%) were treated with probe trabeculotomy (probe TO), 6 (29%) with 360° catheter-assisted trabeculotomy (360° TO) and 7 (33%) with cyclodestructive procedures. IOP was significantly reduced after probe TO and 360° TO after 2 years, from 26.9 mmHg to 17.4 mmHg (pConclusionsIn glaucoma after congenital cataract surgery, both trabeculotomy techniques, lead to good reduction of IOP after 2 years. There is a need for a prospective study with comparison to the use of glaucoma drainage implants.
Published: 2023
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41. Structure and inhibition of Cryptococcus neoformans sterylglucosidase to develop antifungal agents

Author: Nivea Pereira de Sa, Adam Taouil, Jinwoo Kim, Timothy Clement, Reece M. Hoffmann, John E. Burke, Robert C. Rizzo, Iwao Ojima, Maurizio Del Poeta, and Michael V. Airola
Subjects: Science
Abstract: Sterylglucosidase 1 (Sgl1) is a virulence factor in Cryptococcus neoformans that modulates fungal pathogenesis and host response. Here, the authors characterize Sgl1 structurally, identify Sgl1 inhibitors, and demonstrate Sgl1 inhibition has efficacy in mouse models of infection.
Published: 2021
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42. 5607225 ADDITION OF THERAPEUTIC PLASMA EXCHANGE TO RED CELL EXCHANGE IMPROVES OUTCOMES OF FAT EMBOLISM SYNDROME IN SICKLE CELL DISEASE

Author: D.A. Tsitsikas, S. Rowe, A. Bosch, C. Hui, N. Sadasivam, N. Palaskas, S. Pancham, S. Rizvi, J. Taylor, P. Greaves, A. Glenthøj, M. Hoffmann, E. Drasar, and P. Eleftheriou
Subjects: Diseases of the blood and blood-forming organs, RC633-647.5
Published: 2023
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43. The middle lipin domain adopts a membrane-binding dimeric protein fold

Author: Weijing Gu, Shujuan Gao, Huan Wang, Kaelin D. Fleming, Reece M. Hoffmann, Jong Won Yang, Nimi M. Patel, Yong Mi Choi, John E. Burke, Karen Reue, and Michael V. Airola
Subjects: Science
Abstract: Lipins need to bind cell membranes before they can function as phosphatidic acid phosphatases. Here, the authors elucidate the structural basis of lipin membrane-association and identify a lipin domain with a novel protein fold that is critical for membrane binding and full functionality of lipins.
Published: 2021
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44. The Team Approach to Spinal Cord and Dorsal Root Ganglion Stimulation: A Guide for the Advanced Practice Provider

Author: Jonathan M. Hagedorn, MD, Brittney Misercola, MSN, APRN, FNP-C, CFRN, Ashley Comer, APRN, NP-C, Jeanmarie Tari-Blake, NP, Chelsey M. Hoffmann, PA, Pankaj Mehta, MD, and Timothy R. Deer, MD
Subjects: Medicine (General), R5-920
Published: 2021
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45. Short- and long-term agreement and reproducibility of 48-hours intraocular pressure measurements in glaucoma patients

Author: Marion Zimmermann, Bert C. Giers, Anna Beck, Katharina Bell, Herwig Zimmermann, Marlene Hechtner, Esther M. Hoffmann, Norbert Pfeiffer, and Katrin Lorenz
Subjects: 48-hours intraocular pressure profile, Diurnal and nocturnal intraocular pressure measurements, Pressure fluctuation, Intraocular pressure, Glaucoma, Ophthalmology, RE1-994
Abstract: Abstract Background Glaucomatous eyes often show strong intraocular pressure (IOP) fluctuations and individual measurements at different time points are necessary for personalized therapy. To survey IOP variations 48-hours diurnal and nocturnal IOP measurements were performed on two consecutive days. Aims of this study were to investigate the short-term repeatability of 48-hours measurements within one patient’s IOP profile and long-term repeatability between two separate IOP profiles of the same patient. Methods A retrospective cohort study was performed evaluating data of 90 glaucoma patients in a German university medical center between 2006 and 2013. All patients underwent two separate diurnal IOP profiles of 48 h. IOP was measured at 8 am, 2 pm, 6 pm, 9 pm using Goldmann applanation tonometry and at 12 midnight using Perkins tonometry in supine position on two consecutive days. Intraclass correlation coefficients (ICC) were calculated to evaluate agreement for the same time points (each time point agreement) and for consecutive measurements within the IOP profiles (between time point agreement). ICC ≤ 0.4 was defined as poor agreement, 0.4–0.75 as moderate and ≥ 0.75 as excellent. Differences between time points were investigated by Bland Altman plots. Results Each time point measurements of profile 1 showed moderate to excellent agreement (ICCs 0.62–0.93). There was a moderate to excellent agreement for measurements between time points of profile 1 (ICCs day one 0.57–0.86, day two 0.71–0.90). Profile 2 was performed at a median interval of 12.0 months (quartiles 11.0 to 21.0). Each time point agreements within profile 2 showed ICCs from 0.23 to 0.81. It showed moderate to excellent agreement for changes between time points (ICCs 0.53–0.94). Day two demonstrated ICCs from 0.74 to 0.88. Long term IOP repeatability (over both pressure profiles) showed moderate to good agreement (ICCs 0.39–0.67). Conclusions Short and long-term agreement of IOP measurements evaluated by diurnal IOP profiles is moderate to good. Due to mostly moderate agreements, which we believe represent IOP fluctuations, we conclude that it is necessary to perform 48-hours IOP profiles to gain a better overview of the individual IOP fluctuations.
Published: 2021
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46. Toward a Simple Design and Manufacturing Pipeline for Additive Manufacturing.

Author: Vahid Haseltalab, Melik Dolen, Ulas Yaman, and Christoph M. Hoffmann
Published: 2021
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47. Ultrafast modification of the electronic structure of a correlated insulator

Author: O. Grånäs, I. Vaskivskyi, X. Wang, P. Thunström, S. Ghimire, R. Knut, J. Söderström, L. Kjellsson, D. Turenne, R. Y. Engel, M. Beye, J. Lu, D. J. Higley, A. H. Reid, W. Schlotter, G. Coslovich, M. Hoffmann, G. Kolesov, C. Schüßler-Langeheine, A. Styervoyedov, N. Tancogne-Dejean, M. A. Sentef, D. A. Reis, A. Rubio, S. S. P. Parkin, O. Karis, J.-E. Rubensson, O. Eriksson, and H. A. Dürr
Subjects: Physics, QC1-999
Abstract: A nontrivial balance between Coulomb repulsion and kinematic effects determines the electronic structure of correlated electron materials. The use of electromagnetic fields strong enough to rival these native microscopic interactions allows us to study the electronic response as well as the time scales and energies involved in using quantum effects for possible applications. We use element-specific transient x-ray absorption spectroscopy and high-harmonic generation to measure the response to ultrashort off-resonant optical fields in the prototypical correlated electron insulator NiO. Surprisingly, fields of up to 0.22 V/Å lead to no detectable changes in the correlated Ni 3d orbitals contrary to previous predictions. A transient directional charge transfer is uncovered, a behavior that is captured by first-principles theory. Our results highlight the importance of retardation effects in electronic screening and pinpoints a key challenge in functionalizing correlated materials for ultrafast device operation.
Published: 2022
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48. Dynamics of allosteric regulation of the phospholipase C-γ isozymes upon recruitment to membranes

Author: Edhriz Siraliev-Perez, Jordan TB Stariha, Reece M Hoffmann, Brenda RS Temple, Qisheng Zhang, Nicole Hajicek, Meredith L Jenkins, John E Burke, and John Sondek
Subjects: phospholipase C, PLCG1, hydrogen-deuterium exchange, HDX-MS, protein dynamics, allosteric regulation, Medicine, Science, Biology (General), QH301-705.5
Abstract: Numerous receptor tyrosine kinases and immune receptors activate phospholipase C-γ (PLC-γ) isozymes at membranes to control diverse cellular processes including phagocytosis, migration, proliferation, and differentiation. The molecular details of this process are not well understood. Using hydrogen-deuterium exchange mass spectrometry, we show that PLC-γ1 is relatively inert to lipid vesicles that contain its substrate, phosphatidylinositol 4,5-bisphosphate (PIP2), unless first bound to the kinase domain of the fibroblast growth factor receptor (FGFR1). Exchange occurs throughout PLC-γ1 and is exaggerated in PLC-γ1 containing an oncogenic substitution (D1165H) that allosterically activates the lipase. These data support a model whereby initial complex formation shifts the conformational equilibrium of PLC-γ1 to favor activation. This receptor-induced priming of PLC-γ1 also explains the capacity of a kinase-inactive fragment of FGFR1 to modestly enhance the lipase activity of PLC-γ1 operating on lipid vesicles but not a soluble analog of PIP2 and highlights potential cooperativity between receptor engagement and membrane proximity. Priming is expected to be greatly enhanced for receptors embedded in membranes and nearly universal for the myriad of receptors and co-receptors that bind the PLC-γ isozymes.
Published: 2022
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49. Experimental demonstration of novel beam characterization using a polarizable X-band transverse deflection structure

Author: B. Marchetti, A. Grudiev, P. Craievich, R. Assmann, H.-H. Braun, N. Catalan Lasheras, F. Christie, R. D’Arcy, R. Fortunati, R. Ganter, P. González Caminal, M. Hoffmann, M. Huening, S. M. Jaster-Merz, R. Jonas, F. Marcellini, D. Marx, G. McMonagle, J. Osterhoff, M. Pedrozzi, E. Prat Costa, S. Reiche, M. Reukauff, S. Schreiber, G. Tews, M. Vogt, S. Wesch, and W. Wuensch
Subjects: Medicine, Science
Abstract: Abstract The PolariX TDS (Polarizable X-Band Transverse Deflection Structure) is an innovative TDS-design operating in the X-band frequency-range. The design gives full control of the streaking plane, which can be tuned in order to characterize the projections of the beam distribution onto arbitrary transverse axes. This novel feature opens up new opportunities for detailed characterization of the electron beam. In this paper we present first measurements of the Polarix TDS at the FLASHForward beamline at DESY, including three-dimensional reconstruction of the charge-density distribution of the bunch and slice emittance measurements in both transverse directions. The experimental results open the path toward novel and more extensive beam characterization in the direction of multi-dimensional-beam-phase-space reconstruction.
Published: 2021
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50. First observation of secondary childhood glaucoma in Coffin-Siris syndrome: a case report and literature review

Author: Heidi Diel, Can Ding, Franz Grehn, Panagiotis Chronopoulos, Oliver Bartsch, and Esther M. Hoffmann
Subjects: Coffin-Siris syndrome, Coffin-Siris syndrome 9, SOX11 gene, Secondary childhood glaucoma, Anterior segment dysgenesis, Peters anomaly, Ophthalmology, RE1-994
Abstract: Abstract Background Severe congenital ophthalmological malformations and glaucoma might be an important occasional feature in patients with Coffin-Siris syndrome (CSS), especially Coffin-Siris syndrome 9 (CSS9, OMIM #615866) caused by SOX11 mutation. Recently, primary (open-angle) glaucoma was described in two children with the most common form of Coffin-Siris syndrome, CSS1 (OMIM #135900) by ARID1B (AT-rich interaction domain-containing protein 1B) gene mutation. In this article, we present the first report of glaucoma with Coffin-Siris syndrome 9 as well as the first report of secondary glaucoma with any form of Coffin-Siris syndrome. These findings indicate that secondary glaucoma is an occasional finding in patients with Coffin-Siris syndrome. Case presentation A child with secondary childhood glaucoma and additional ocular manifestations was evaluated and treated at the childhood glaucoma centre in Mainz, Germany. Examination under general anaesthesia revealed ocular anterior segment dysgenesis (ASD) (Peters type iridocorneal dysgenesis) in combination with congenital limbal stem cell deficiency (LSCD), aniridia, and cataract. The patient also had multiple other congenital anomalies and severe developmental delay. To explain his combination of anomalies, molecular genetic analysis from peripheral blood was performed in late 2018 and early 2019. Following normal findings with a panel diagnostic of 18 genes associated with congenital glaucoma, whole exome sequencing was performed and revealed a novel likely pathogenic heterozygous variant c.251G>T, p.(Gly84Val) in the SOX11 gene (SRY-related HMG-box gene 11). The variant had occurred de novo. Thus, the multiple congenital anomalies and developmental delay of the patient represented Coffin-Siris syndrome 9 (CSS9, OMIM #615866). Conclusions When eye diseases occur in combination with other systemic features, genetic analysis can be seminal. Results indicate that glaucoma is an occasional feature of patients with Coffin-Siris syndrome. As early treatment may improve the visual outcome of patients with glaucoma, we suggest that patients with Coffin-Siris syndrome should receive specific ophthalmological screening.
Published: 2021
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