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3. A major shift of viral and nutritional risk factors affects the hepatocellular carcinoma risk among Ivorian patients: a preliminary report

Author

M’Bengue, Alphonsine Kouassi, Doumbia, Moussa, Denoman, Stéphane Romaric, Ouattara, Djeneba Ngnoh, Adoubi, Innocent, Pineau, Pascal, Institut Pasteur de Côte d'Ivoire, Réseau International des Instituts Pasteur (RIIP), Département d'Epidémiologie-Recherche Clinique, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Université Félix Houphouët-Boigny (UFHB), Organisation Nucléaire et Oncogenèse / Nuclear Organization and Oncogenesis, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Felix Houphouët Boigny [Abidjan, Ivory Coast], and Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
Abstract

International audience; Hepatocellular carcinoma (HCC) is a major public health concern in Sub-Saharan Africa. Early research in Ivory Coastshowed that chronic hepatitis B and aflatoxin B1 exposure were the two most important etiological agents of HCCin the country but, surprisingly, no survey analyzing HCC etiologies has been conducted since decades.In a preliminary report, we characterized for hepatitis B and C markers 30 consecutive cases of HCC recruited fromAbidjan hospitals between June 2011 and December 2012. Nutritional and lifestyle features of patients were analyzedas well. The mean age of the patients was 53 ± 15 years with a sex ratio (M:F = 2.7). HBsAg was the most frequent viralmarker in the series (63 %). All HBV isolates belonged to genotype E. With regards to regional standard, anti-HCVreached a very high level (47 %) in the present series. Hepatitis C was more frequent among patients living outsideAbidjan (83 vs 23 %, P = 0.009). Patients living in Abidjan were significantly younger than individual living elsewhere inthe country (48 ± 14 vs 60 ± 16 years old, P = 0.038) reflecting a possible role for local environmental pollution in tumorprogression. Finally, we observed that patients born in Mandé/Gur-speaking regions (North) were younger (48 ± 14 vs59 ± 15, P = 0.05) and consumed maize more frequently (80 vs 26 %, P = 0.009) than other patients. Interestingly, maizeconsumption was associated with a trend for aminotransferases elevation (mean = 1.7-1.8 fold, P = 0.06) suggesting adirect hepatic toxicity of this staple food in Ivory Coast. In conclusion, our work indicates that HCC epidemiologyunderwent recently majordrifts in Ivory Coast.

Published
2015

4. A major shift of viral and nutritional risk factors affects the hepatocellular carcinoma risk among Ivorian patients: a preliminary report.

Author

M'Bengue, Alphonsine Kouassi, Doumbia, Moussa, Denoman, Stéphane Romaric, Ouattara, Djeneba Ngnoh, Adoubi, Innocent, and Pineau, Pascal

Subjects
*AFLATOXINS, *ETHNIC groups, *HEPATOCELLULAR carcinoma, *POLYMERASE chain reaction, *PUBLIC health, *REPORT writing, *STATISTICS, *TIME, *CROSS-sectional method, *DATA analysis software, *GENOTYPES, *DISEASE risk factors
Abstract

Hepatocellular carcinoma (HCC) is a major public health concern in Sub-Saharan Africa. Early research in Ivory Coast showed that chronic hepatitis B and aflatoxin B1 exposure were the two most important etiological agents of HCC in the country but, surprisingly, no survey analyzing HCC etiologies has been conducted since decades. In a preliminary report, we characterized for hepatitis B and C markers 30 consecutive cases of HCC recruited from Abidjan hospitals between June 2011 and December 2012. Nutritional and lifestyle features of patients were analyzed as well. The mean age of the patients was 53 ± 15 years with a sex ratio (M:F = 2.7). HBsAg was the most frequent viral marker in the series (63 %). All HBV isolates belonged to genotype E. With regards to regional standard, anti-HCV reached a very high level (47 %) in the present series. Hepatitis C was more frequent among patients living outside Abidjan (83 vs 23 %, P = 0.009). Patients living in Abidjan were significantly younger than individual living elsewhere in the country (48 ± 14 vs 60 ± 16 years old, P = 0.038) reflecting a possible role for local environmental pollution in tumor progression. Finally, we observed that patients born in Mandé/Gur-speaking regions (North) were younger (48 ± 14 vs 59 ± 15, P = 0.05) and consumed maize more frequently (80 vs 26 %, P = 0.009) than other patients. Interestingly, maize consumption was associated with a trend for aminotransferases elevation (mean = 1.7-1.8 fold, P = 0.06) suggesting a direct hepatic toxicity of this staple food in Ivory Coast. In conclusion, our work indicates that HCC epidemiology underwent recently major drifts in Ivory Coast. [ABSTRACT FROM AUTHOR]

Published
2015
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