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Background Dyspepsia (namely, the functional dyspepsia) in children, is a common pediatric disease that has a high recurrence rate. Severe dyspepsia will affect the nutritional intake of children, and may further impair their physical development and even mental health. Objective To systematically review the effectiveness and safety of Changyanning Granules in the treatment of dyspepsia in children. Methods We searched databases of CNKI, WanFang Data, CQVIP, and SinoMed for randomized controlled trials (RCTs) in Chinese and searched databases of PubMed, The Cochrane Libarary, EMBase, Web of Science for relevant RCTs in English from inception to May 2021. Regarding children with dyspepsia treated by Changyanning Granules or Changyanning Granules in combination with routine western treatment〔Live Combined Bifidobacterium and Lactobacillus Tablets (LCBLT) or Motilium Tablets (MT) 〕 (experimental group) compared with those treated with Xiaoer Xishi Pian (a Chinese patent medicine) or routine western treatment (LCBLT or MT) regardless of dosage, administration route and duration of treatment. We used response rate as the primary outcome indicator, and incidence of adverse reactions and clinical symptoms disappearing time as secondary outcome indicators. We used the Cochrane Handbook for Systematic Reviews of Interventions (Version 5.1) and RevMan 5.3 for conducting the meta-analysis. Results Six RCTs were included, involving 1 150 cases (575 in the experimental group and 575 in the control group) . Meta-analysis showed that Changyanning Granules were superior to Xiaoer Xishi Pian in terms of overall response rate〔RR=1.57, 95%CI (1.27, 1.94) , P0.05) . Conclusion For children with dyspepsia, available evidence has demonstrated that using Changyanning Granules alone, or in combination with LCBLT or MT, could improve the overall response rate, shorten the clinical symptoms disappearing time with relatively low incidence of adverse reactions. However, due to low quality of included RCTs, our conclusion needs to be further verified by RCTs meeting the international standards with a large sample size, and rigorous design.

Public–private partnership (PPP) project risk management through risk-factor attention has been widely studied for a long time; however, it remains unknown whether the attention degree of risk indicators corresponds to their loss degrees. This study investigated the difference between risk-factor attention and losses in PPP projects by utilizing text mining, questionnaire survey, fuzzy comprehensive evaluation, and importance-performance analysis methods (IPA). The results show a surprising attention-loss phenomenon: some factors attract more attention but bring fewer losses; other factors attract less attention while causing more losses. The research findings provided valuable references not only for PPP project managers but also for further studies on the risk management of PPP projects. [ABSTRACT FROM AUTHOR]

Urban population size dynamic adjustment has been widely studied for a long time; however, the dynamic adjustment at the urban hierarchy level remains unknown. This study utilises China's urban population data to investigate the dynamic adjustment. Specifically, we utilise methods of the Gini coefficient, linear regression, and coefficients of Spearman, and Moran's I to explore the dynamic adjustment tendency, adjustment rate and correlation of urban population size distribution of different urban hierarchies and groups of different urban hierarchies. We find that the urban population size spatial distribution is gradually even within the same urban hierarchy. The adjustment rate to be even of Megacity II is the highest, and Megacity I is the bottom. We also find the population size spatial distribution of the whole urban system is gradually uneven. We explore the dynamic process by sorting urban hierarchies into six groups. Furthermore, we find there is a complex correlation between different urban hierarchies and global spatial correlation among China cities. These results are valuable as references for Chinese policy-makers and practitioners and will enable them to adopt sustainable land use and urban population management measures. The study outcomes will also benefit future studies on spatial population size distribution in international communities. [ABSTRACT FROM AUTHOR]